The effect of stress on the expression of the amyloid precursor protein in rat brain. / Sayer, Rachel; Robertson, Deborah; Balfour, David J. K.; Breen, Kieran C.; Stewart, Caroline A.
In: Neuroscience Letters, Vol. 431, No. 3, 06.02.2008, p. 197-200.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of stress on the expression of the amyloid precursor protein in rat brain
A1 - Sayer,Rachel
A1 - Robertson,Deborah
A1 - Balfour,David J. K.
A1 - Breen,Kieran C.
A1 - Stewart,Caroline A.
AU - Sayer,Rachel
AU - Robertson,Deborah
AU - Balfour,David J. K.
AU - Breen,Kieran C.
AU - Stewart,Caroline A.
PY - 2008/2/6
Y1 - 2008/2/6
N2 - <p>The abnormal processing of the amyloid precursor protein (APP) is a pivotal event in the development of the unique pathology that defines Alzheimer's disease (AD). Stress, and the associated increase in corticosteroids, appear to accelerate brain ageing and may increase vulnerability to Alzheimer's disease via altered APP processing. In this study, rats were repeatedly exposed to an unavoidable stressor, an open elevated platform. Previous studies in this laboratory have shown that a single exposure produces a marked increase in plasma corticosterone levels but animals develop tolerance to this effect between 10 and 20 daily sessions. Twenty-four hours after stress, there was an increase in the ratio of the deglycosylated form of APP in the particulate fraction of the brain, which subsequently habituated after 20 days. The levels of soluble APP (APPs) tended to be lower in the stress groups compared to controls except for a significant increase in the hippocampus after 20 days of platform exposure. Since APPs is reported to have neurotrophic properties, this increased release may represent a neuroprotective response to repeated stress. It is possible that the ability to mount this response decreases with age thus increasing the vulnerability to stress-induced AD-related pathology. (c) 2007 Elsevier Ireland Ltd. All rights reserved.</p>
AB - <p>The abnormal processing of the amyloid precursor protein (APP) is a pivotal event in the development of the unique pathology that defines Alzheimer's disease (AD). Stress, and the associated increase in corticosteroids, appear to accelerate brain ageing and may increase vulnerability to Alzheimer's disease via altered APP processing. In this study, rats were repeatedly exposed to an unavoidable stressor, an open elevated platform. Previous studies in this laboratory have shown that a single exposure produces a marked increase in plasma corticosterone levels but animals develop tolerance to this effect between 10 and 20 daily sessions. Twenty-four hours after stress, there was an increase in the ratio of the deglycosylated form of APP in the particulate fraction of the brain, which subsequently habituated after 20 days. The levels of soluble APP (APPs) tended to be lower in the stress groups compared to controls except for a significant increase in the hippocampus after 20 days of platform exposure. Since APPs is reported to have neurotrophic properties, this increased release may represent a neuroprotective response to repeated stress. It is possible that the ability to mount this response decreases with age thus increasing the vulnerability to stress-induced AD-related pathology. (c) 2007 Elsevier Ireland Ltd. All rights reserved.</p>
KW - elevated platform
KW - habituation
KW - amyloid
KW - Alzheimer's disease
KW - hippocampus
KW - glycosylation
KW - ALZHEIMERS-DISEASE
KW - IN-VIVO
KW - BETA
KW - MEMORY
KW - MICE
KW - CORTICOSTEROIDS
KW - GLUCOCORTICOIDS
KW - PROLIFERATION
KW - ENHANCEMENT
KW - PROGRESSION
U2 - 10.1016/j.neulet.2007.11.032
DO - 10.1016/j.neulet.2007.11.032
M1 - Article
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
VL - 431
SP - 197
EP - 200
ER -