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The effect of stress on the expression of the amyloid precursor protein in rat brain

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The effect of stress on the expression of the amyloid precursor protein in rat brain. / Sayer, Rachel; Robertson, Deborah; Balfour, David J. K.; Breen, Kieran C.; Stewart, Caroline A.

In: Neuroscience Letters, Vol. 431, No. 3, 06.02.2008, p. 197-200.

Research output: Contribution to journalArticle

Harvard

Sayer, R, Robertson, D, Balfour, DJK, Breen, KC & Stewart, CA 2008, 'The effect of stress on the expression of the amyloid precursor protein in rat brain' Neuroscience Letters, vol 431, no. 3, pp. 197-200., 10.1016/j.neulet.2007.11.032

APA

Sayer, R., Robertson, D., Balfour, D. J. K., Breen, K. C., & Stewart, C. A. (2008). The effect of stress on the expression of the amyloid precursor protein in rat brain. Neuroscience Letters, 431(3), 197-200. 10.1016/j.neulet.2007.11.032

Vancouver

Sayer R, Robertson D, Balfour DJK, Breen KC, Stewart CA. The effect of stress on the expression of the amyloid precursor protein in rat brain. Neuroscience Letters. 2008 Feb 6;431(3):197-200. Available from: 10.1016/j.neulet.2007.11.032

Author

Sayer, Rachel; Robertson, Deborah; Balfour, David J. K.; Breen, Kieran C.; Stewart, Caroline A. / The effect of stress on the expression of the amyloid precursor protein in rat brain.

In: Neuroscience Letters, Vol. 431, No. 3, 06.02.2008, p. 197-200.

Research output: Contribution to journalArticle

Bibtex - Download

@article{1579da23a6604cbd9db17e78f4d03c86,
title = "The effect of stress on the expression of the amyloid precursor protein in rat brain",
keywords = "elevated platform, habituation, amyloid, Alzheimer's disease, hippocampus, glycosylation, ALZHEIMERS-DISEASE, IN-VIVO, BETA, MEMORY, MICE, CORTICOSTEROIDS, GLUCOCORTICOIDS, PROLIFERATION, ENHANCEMENT, PROGRESSION",
author = "Rachel Sayer and Deborah Robertson and Balfour, {David J. K.} and Breen, {Kieran C.} and Stewart, {Caroline A.}",
year = "2008",
doi = "10.1016/j.neulet.2007.11.032",
volume = "431",
number = "3",
pages = "197--200",
journal = "Neuroscience Letters",
issn = "0304-3940",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - The effect of stress on the expression of the amyloid precursor protein in rat brain

A1 - Sayer,Rachel

A1 - Robertson,Deborah

A1 - Balfour,David J. K.

A1 - Breen,Kieran C.

A1 - Stewart,Caroline A.

AU - Sayer,Rachel

AU - Robertson,Deborah

AU - Balfour,David J. K.

AU - Breen,Kieran C.

AU - Stewart,Caroline A.

PY - 2008/2/6

Y1 - 2008/2/6

N2 - <p>The abnormal processing of the amyloid precursor protein (APP) is a pivotal event in the development of the unique pathology that defines Alzheimer's disease (AD). Stress, and the associated increase in corticosteroids, appear to accelerate brain ageing and may increase vulnerability to Alzheimer's disease via altered APP processing. In this study, rats were repeatedly exposed to an unavoidable stressor, an open elevated platform. Previous studies in this laboratory have shown that a single exposure produces a marked increase in plasma corticosterone levels but animals develop tolerance to this effect between 10 and 20 daily sessions. Twenty-four hours after stress, there was an increase in the ratio of the deglycosylated form of APP in the particulate fraction of the brain, which subsequently habituated after 20 days. The levels of soluble APP (APPs) tended to be lower in the stress groups compared to controls except for a significant increase in the hippocampus after 20 days of platform exposure. Since APPs is reported to have neurotrophic properties, this increased release may represent a neuroprotective response to repeated stress. It is possible that the ability to mount this response decreases with age thus increasing the vulnerability to stress-induced AD-related pathology. (c) 2007 Elsevier Ireland Ltd. All rights reserved.</p>

AB - <p>The abnormal processing of the amyloid precursor protein (APP) is a pivotal event in the development of the unique pathology that defines Alzheimer's disease (AD). Stress, and the associated increase in corticosteroids, appear to accelerate brain ageing and may increase vulnerability to Alzheimer's disease via altered APP processing. In this study, rats were repeatedly exposed to an unavoidable stressor, an open elevated platform. Previous studies in this laboratory have shown that a single exposure produces a marked increase in plasma corticosterone levels but animals develop tolerance to this effect between 10 and 20 daily sessions. Twenty-four hours after stress, there was an increase in the ratio of the deglycosylated form of APP in the particulate fraction of the brain, which subsequently habituated after 20 days. The levels of soluble APP (APPs) tended to be lower in the stress groups compared to controls except for a significant increase in the hippocampus after 20 days of platform exposure. Since APPs is reported to have neurotrophic properties, this increased release may represent a neuroprotective response to repeated stress. It is possible that the ability to mount this response decreases with age thus increasing the vulnerability to stress-induced AD-related pathology. (c) 2007 Elsevier Ireland Ltd. All rights reserved.</p>

KW - elevated platform

KW - habituation

KW - amyloid

KW - Alzheimer's disease

KW - hippocampus

KW - glycosylation

KW - ALZHEIMERS-DISEASE

KW - IN-VIVO

KW - BETA

KW - MEMORY

KW - MICE

KW - CORTICOSTEROIDS

KW - GLUCOCORTICOIDS

KW - PROLIFERATION

KW - ENHANCEMENT

KW - PROGRESSION

U2 - 10.1016/j.neulet.2007.11.032

DO - 10.1016/j.neulet.2007.11.032

M1 - Article

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

VL - 431

SP - 197

EP - 200

ER -

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    This document was posted here by permission of the publisher. At the time of the deposit, it included all changes made during peer review, copy editing, and publishing. The U. S. National Library of Medicine is responsible for all links within the document and for incorporating any publisher-supplied amendments or retractions issued subsequently. The published journal article, guaranteed to be such by Elsevier, is available for free, on ScienceDirect, at: http://dx.crossref.org/10.1016/j.neulet.2007.11.032

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