Discovery - University of Dundee - Online Publications

Library & Learning Centre

The effectiveness of sealants in managing caries lesions

The effectiveness of sealants in managing caries lesions

Research output: Contribution to journalArticle

View graph of relations


  • S. O. Griffin
  • E. Oong
  • W. Kohn
  • B. Vidakovic
  • B. F. Gooch
  • J. Bader
  • J. Clarkson
  • M. R. Fontana
  • D. M. Meyer
  • R. G. Rozier
  • J. A. Weintraub
  • D. T. Zero
  • CDC Dent Sealant Systmatic Review

Research units


Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalJournal of Dental Research
Issue number2
StatePublished - Feb 2008


A barrier to providing sealants is concern about inadvertently sealing over caries. This meta-analysis examined the effectiveness of sealants in preventing caries progression. We searched electronic databases for comparative studies examining caries progression in sealed permanent teeth. We used a random-effects model to estimate percentage reduction in the probability of caries progression in sealed vs. unsealed carious teeth. Six studies, including 4 randomized-controlled trials (RCT) judged to be of fair quality, were included in the analysis (384 persons, 840 teeth, and 1090 surfaces). The median annual percentage of non-cavitated lesions progressing was 2.6% for sealed and 12.6% for unsealed carious teeth. The summary prevented fraction for RCT was 71.3% (95% CI: 52.8%-82.5, no heterogeneity) up to 5 years after placement. Despite variation among studies in design and conduct, sensitivity analysis found the effect to be consistent in size and direction. Sealing non-cavitated caries in permanent teeth is effective in reducing caries progression.



Library & Learning Centre

Contact | Accessibility | Policy