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The Effects of Vitamin D Supplementation on Physical Function and Quality of Life in Older Patients With Heart Failure A Randomized Controlled Trial

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The Effects of Vitamin D Supplementation on Physical Function and Quality of Life in Older Patients With Heart Failure A Randomized Controlled Trial. / Witham, Miles D. (Lead / Corresponding author); Crighton, Linda J.; Gillespie, Neil D.; Struthers, Allan D.; McMurdo, Marion E. T.

In: Circulation: Heart Failure, Vol. 3, No. 2, 03.2010, p. 195-201.

Research output: Contribution to journalArticle

Harvard

Witham, MD, Crighton, LJ, Gillespie, ND, Struthers, AD & McMurdo, MET 2010, 'The Effects of Vitamin D Supplementation on Physical Function and Quality of Life in Older Patients With Heart Failure A Randomized Controlled Trial' Circulation: Heart Failure, vol 3, no. 2, pp. 195-201.

APA

Witham, M. D., Crighton, L. J., Gillespie, N. D., Struthers, A. D., & McMurdo, M. E. T. (2010). The Effects of Vitamin D Supplementation on Physical Function and Quality of Life in Older Patients With Heart Failure A Randomized Controlled Trial. Circulation: Heart Failure, 3(2), 195-201doi: 10.1161/CIRCHEARTFAILURE.109.907899

Vancouver

Witham MD, Crighton LJ, Gillespie ND, Struthers AD, McMurdo MET. The Effects of Vitamin D Supplementation on Physical Function and Quality of Life in Older Patients With Heart Failure A Randomized Controlled Trial. Circulation: Heart Failure. 2010 Mar;3(2):195-201.

Author

Witham, Miles D. (Lead / Corresponding author); Crighton, Linda J.; Gillespie, Neil D.; Struthers, Allan D.; McMurdo, Marion E. T. / The Effects of Vitamin D Supplementation on Physical Function and Quality of Life in Older Patients With Heart Failure A Randomized Controlled Trial.

In: Circulation: Heart Failure, Vol. 3, No. 2, 03.2010, p. 195-201.

Research output: Contribution to journalArticle

Bibtex - Download

@article{57aaa7c74e8a4605ae9b8dbd6f2d9d4f,
title = "The Effects of Vitamin D Supplementation on Physical Function and Quality of Life in Older Patients With Heart Failure A Randomized Controlled Trial",
author = "Witham, {Miles D.} and Crighton, {Linda J.} and Gillespie, {Neil D.} and Struthers, {Allan D.} and McMurdo, {Marion E. T.}",
year = "2010",
volume = "3",
number = "2",
pages = "195--201",
journal = "Circulation: Heart Failure",
issn = "1941-3289",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - The Effects of Vitamin D Supplementation on Physical Function and Quality of Life in Older Patients With Heart Failure A Randomized Controlled Trial

A1 - Witham,Miles D.

A1 - Crighton,Linda J.

A1 - Gillespie,Neil D.

A1 - Struthers,Allan D.

A1 - McMurdo,Marion E. T.

AU - Witham,Miles D.

AU - Crighton,Linda J.

AU - Gillespie,Neil D.

AU - Struthers,Allan D.

AU - McMurdo,Marion E. T.

PY - 2010/3

Y1 - 2010/3

N2 - <p>Background-Low 25-hydroxyvitamin D levels, commonly found in older patients with heart failure, may contribute to the chronic inflammation and skeletal myopathy that lead to poor exercise tolerance. We tested whether vitamin D supplementation of patients with heart failure and vitamin D insufficiency can improve physical function and quality of life.</p><p>Methods and Results-In a randomized, parallel group, double-blind, placebo-controlled trial, patients with systolic heart failure aged &gt;= 70 years with 25-hydroxyvitamin D levels &lt;50 nmol/L (20 ng/mL) received 100 000 U of oral vitamin D2 or placebo at baseline and 10 weeks. Outcomes measured at baseline, 10 weeks, and 20 weeks were 6-minute walk distance, quality of life (Minnesota score), daily activity measured by accelerometry, Functional Limitations Profile, B-type natriuretic peptide, and tumor necrosis factor-alpha. Participants in the vitamin D group had an increase in their 25-hydroxyvitamin D levels compared with placebo at 10 weeks (22.9 versus 2.3 nmol/L [9.2 versus 0.9 ng/mL]; P &lt; 0.001) and maintained this increase at 20 weeks. The 6-minute walk did not improve in the treatment group relative to placebo. No significant benefit was seen on timed up and go testing, subjective measures of function, daily activity, or tumor necrosis factor. Quality of life worsened by a small, but significant amount in the treatment group relative to placebo. B-type natriuretic peptide decreased in the treatment group relative to placebo (-22 versus +78 pg/mL at 10 weeks; P = 0.04).</p><p>Conclusions-Vitamin D supplementation did not improve functional capacity or quality of life in older patients with heart failure with vitamin D insufficiency.</p><p>Clinical Trial Registration-www.controlled-trials.com. Identifier: ISRCTN51372896. (Circ Heart Fail. 2010; 3:195-201.)</p>

AB - <p>Background-Low 25-hydroxyvitamin D levels, commonly found in older patients with heart failure, may contribute to the chronic inflammation and skeletal myopathy that lead to poor exercise tolerance. We tested whether vitamin D supplementation of patients with heart failure and vitamin D insufficiency can improve physical function and quality of life.</p><p>Methods and Results-In a randomized, parallel group, double-blind, placebo-controlled trial, patients with systolic heart failure aged &gt;= 70 years with 25-hydroxyvitamin D levels &lt;50 nmol/L (20 ng/mL) received 100 000 U of oral vitamin D2 or placebo at baseline and 10 weeks. Outcomes measured at baseline, 10 weeks, and 20 weeks were 6-minute walk distance, quality of life (Minnesota score), daily activity measured by accelerometry, Functional Limitations Profile, B-type natriuretic peptide, and tumor necrosis factor-alpha. Participants in the vitamin D group had an increase in their 25-hydroxyvitamin D levels compared with placebo at 10 weeks (22.9 versus 2.3 nmol/L [9.2 versus 0.9 ng/mL]; P &lt; 0.001) and maintained this increase at 20 weeks. The 6-minute walk did not improve in the treatment group relative to placebo. No significant benefit was seen on timed up and go testing, subjective measures of function, daily activity, or tumor necrosis factor. Quality of life worsened by a small, but significant amount in the treatment group relative to placebo. B-type natriuretic peptide decreased in the treatment group relative to placebo (-22 versus +78 pg/mL at 10 weeks; P = 0.04).</p><p>Conclusions-Vitamin D supplementation did not improve functional capacity or quality of life in older patients with heart failure with vitamin D insufficiency.</p><p>Clinical Trial Registration-www.controlled-trials.com. Identifier: ISRCTN51372896. (Circ Heart Fail. 2010; 3:195-201.)</p>

KW - older

KW - heart failure

KW - vitamin D

KW - PLACEBO-CONTROLLED TRIAL

KW - CALCIUM SUPPLEMENTATION

KW - DOUBLE-BLIND

KW - ENDOTHELIAL FUNCTION

KW - BLOOD-PRESSURE

KW - ELDERLY-WOMEN

KW - RISK-FACTOR

KW - COMMUNITY

KW - SPIRONOLACTONE

KW - PEOPLE

U2 - 10.1161/CIRCHEARTFAILURE.109.907899

DO - 10.1161/CIRCHEARTFAILURE.109.907899

M1 - Article

JO - Circulation: Heart Failure

JF - Circulation: Heart Failure

SN - 1941-3289

IS - 2

VL - 3

SP - 195

EP - 201

ER -

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