Discovery - University of Dundee - Online Publications

Library & Learning Centre

The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness

The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness

Research output: Contribution to journalArticle

View graph of relations

Authors

  • Michael A. J. Ferguson
  • John S. Brimacombe
  • Jillian R. Brown
  • Arthur Crossman
  • Alexander Dix
  • Robert A. Field
  • M. Lucia S. Guther
  • Kenneth G. Milne
  • Deepak K. Sharma
  • Terry K. Smith

Research units

Info

Original languageEnglish
Pages327-340
Number of pages14
JournalBiochimica et Biophysica Acta. Molecular Basis of Disease
Journal publication date1999
Volume1455
Issue2-3
DOIs
StatePublished

Abstract

African sleeping sickness is a debilitating and often fatal disease caused by tsetse fly transmitted African trypanosomes. These extracellular protozoan parasites survive in the human bloodstream by virtue of a dense cell surface coat made of variant surface glycoprotein. The parasites have a repertoire of several hundred immunologically distinct variant surface glycoproteins and they evade the host immune response by antigenic variation. All variant surface glycoproteins are anchored to the plasma membrane via glycosylphosphatidylinositol membrane anchors and compounds that inhibit the assembly or transfer of these anchors could have trypanocidal potential. This article compares glycosylphosphatidylinositol biosynthesis in African trypanosomes and mammalian cells and identifies several steps that could be targets for the development of parasite-specific therapeutic agents. (C) 1999 Elsevier Science B.V. All rights reserved.

Documents

Library & Learning Centre

Contact | Accessibility | Policy