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The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness

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The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness. / Ferguson, Michael A. J.; Brimacombe, John S.; Brown, Jillian R.; Crossman, Arthur; Dix, Alexander; Field, Robert A.; Guther, M. Lucia S.; Milne, Kenneth G.; Sharma, Deepak K.; Smith, Terry K.

In: Biochimica et Biophysica Acta. Molecular Basis of Disease, Vol. 1455, No. 2-3, 1999, p. 327-340.

Research output: Contribution to journalArticle

Harvard

Ferguson, MAJ, Brimacombe, JS, Brown, JR, Crossman, A, Dix, A, Field, RA, Guther, MLS, Milne, KG, Sharma, DK & Smith, TK 1999, 'The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness' Biochimica et Biophysica Acta. Molecular Basis of Disease, vol 1455, no. 2-3, pp. 327-340.

APA

Ferguson, M. A. J., Brimacombe, J. S., Brown, J. R., Crossman, A., Dix, A., Field, R. A., Guther, M. L. S., Milne, K. G., Sharma, D. K., & Smith, T. K. (1999). The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1455(2-3), 327-340doi: 10.1016/S0925-4439(99)00058-7

Vancouver

Ferguson MAJ, Brimacombe JS, Brown JR, Crossman A, Dix A, Field RA et al. The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness. Biochimica et Biophysica Acta. Molecular Basis of Disease. 1999;1455(2-3):327-340.

Author

Ferguson, Michael A. J.; Brimacombe, John S.; Brown, Jillian R.; Crossman, Arthur; Dix, Alexander; Field, Robert A.; Guther, M. Lucia S.; Milne, Kenneth G.; Sharma, Deepak K.; Smith, Terry K. / The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness.

In: Biochimica et Biophysica Acta. Molecular Basis of Disease, Vol. 1455, No. 2-3, 1999, p. 327-340.

Research output: Contribution to journalArticle

Bibtex - Download

@article{91a01b8d1a7e4425a54fa155dd27204c,
title = "The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness",
author = "Ferguson, {Michael A. J.} and Brimacombe, {John S.} and Brown, {Jillian R.} and Arthur Crossman and Alexander Dix and Field, {Robert A.} and Guther, {M. Lucia S.} and Milne, {Kenneth G.} and Sharma, {Deepak K.} and Smith, {Terry K.}",
year = "1999",
volume = "1455",
number = "2-3",
pages = "327--340",
journal = "Biochimica et Biophysica Acta. Molecular Basis of Disease",
issn = "0925-4439",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness

A1 - Ferguson,Michael A. J.

A1 - Brimacombe,John S.

A1 - Brown,Jillian R.

A1 - Crossman,Arthur

A1 - Dix,Alexander

A1 - Field,Robert A.

A1 - Guther,M. Lucia S.

A1 - Milne,Kenneth G.

A1 - Sharma,Deepak K.

A1 - Smith,Terry K.

AU - Ferguson,Michael A. J.

AU - Brimacombe,John S.

AU - Brown,Jillian R.

AU - Crossman,Arthur

AU - Dix,Alexander

AU - Field,Robert A.

AU - Guther,M. Lucia S.

AU - Milne,Kenneth G.

AU - Sharma,Deepak K.

AU - Smith,Terry K.

PY - 1999

Y1 - 1999

N2 - <p>African sleeping sickness is a debilitating and often fatal disease caused by tsetse fly transmitted African trypanosomes. These extracellular protozoan parasites survive in the human bloodstream by virtue of a dense cell surface coat made of variant surface glycoprotein. The parasites have a repertoire of several hundred immunologically distinct variant surface glycoproteins and they evade the host immune response by antigenic variation. All variant surface glycoproteins are anchored to the plasma membrane via glycosylphosphatidylinositol membrane anchors and compounds that inhibit the assembly or transfer of these anchors could have trypanocidal potential. This article compares glycosylphosphatidylinositol biosynthesis in African trypanosomes and mammalian cells and identifies several steps that could be targets for the development of parasite-specific therapeutic agents. (C) 1999 Elsevier Science B.V. All rights reserved.</p>

AB - <p>African sleeping sickness is a debilitating and often fatal disease caused by tsetse fly transmitted African trypanosomes. These extracellular protozoan parasites survive in the human bloodstream by virtue of a dense cell surface coat made of variant surface glycoprotein. The parasites have a repertoire of several hundred immunologically distinct variant surface glycoproteins and they evade the host immune response by antigenic variation. All variant surface glycoproteins are anchored to the plasma membrane via glycosylphosphatidylinositol membrane anchors and compounds that inhibit the assembly or transfer of these anchors could have trypanocidal potential. This article compares glycosylphosphatidylinositol biosynthesis in African trypanosomes and mammalian cells and identifies several steps that could be targets for the development of parasite-specific therapeutic agents. (C) 1999 Elsevier Science B.V. All rights reserved.</p>

U2 - 10.1016/S0925-4439(99)00058-7

DO - 10.1016/S0925-4439(99)00058-7

M1 - Article

JO - Biochimica et Biophysica Acta. Molecular Basis of Disease

JF - Biochimica et Biophysica Acta. Molecular Basis of Disease

SN - 0925-4439

IS - 2-3

VL - 1455

SP - 327

EP - 340

ER -

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