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The impact of population-based faecal occult blood test screening on colorectal cancer mortality

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The impact of population-based faecal occult blood test screening on colorectal cancer mortality : a matched cohort study. / Libby, G. (Lead / Corresponding author); Brewster, D. H.; McClements, P. L.; Carey, F. A.; Black, R. J.; Birrell, J.; Fraser, C. G.; Steele, R. J. C. (Lead / Corresponding author).

In: British Journal of Cancer, Vol. 107, No. 2, 10.07.2012, p. 255-259.

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Harvard

Libby, G, Brewster, DH, McClements, PL, Carey, FA, Black, RJ, Birrell, J, Fraser, CG & Steele, RJC 2012, 'The impact of population-based faecal occult blood test screening on colorectal cancer mortality: a matched cohort study' British Journal of Cancer, vol 107, no. 2, pp. 255-259., 10.1038/bjc.2012.277

APA

Libby, G., Brewster, D. H., McClements, P. L., Carey, F. A., Black, R. J., Birrell, J., ... Steele, R. J. C. (2012). The impact of population-based faecal occult blood test screening on colorectal cancer mortality: a matched cohort study. British Journal of Cancer, 107(2), 255-259. 10.1038/bjc.2012.277

Vancouver

Libby G, Brewster DH, McClements PL, Carey FA, Black RJ, Birrell J et al. The impact of population-based faecal occult blood test screening on colorectal cancer mortality: a matched cohort study. British Journal of Cancer. 2012 Jul 10;107(2):255-259. Available from: 10.1038/bjc.2012.277

Author

Libby, G. (Lead / Corresponding author); Brewster, D. H.; McClements, P. L.; Carey, F. A.; Black, R. J.; Birrell, J.; Fraser, C. G.; Steele, R. J. C. (Lead / Corresponding author) / The impact of population-based faecal occult blood test screening on colorectal cancer mortality : a matched cohort study.

In: British Journal of Cancer, Vol. 107, No. 2, 10.07.2012, p. 255-259.

Research output: Contribution to journalArticle

Bibtex - Download

@article{b3148e4efdcf457da7a2b3b64a8e946e,
title = "The impact of population-based faecal occult blood test screening on colorectal cancer mortality: a matched cohort study",
author = "G. Libby and Brewster, {D. H.} and McClements, {P. L.} and Carey, {F. A.} and Black, {R. J.} and J. Birrell and Fraser, {C. G.} and Steele, {R. J. C.}",
year = "2012",
doi = "10.1038/bjc.2012.277",
volume = "107",
number = "2",
pages = "255--259",
journal = "British Journal of Cancer",
issn = "0007-0920",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - The impact of population-based faecal occult blood test screening on colorectal cancer mortality

T2 - a matched cohort study

A1 - Libby,G.

A1 - Brewster,D. H.

A1 - McClements,P. L.

A1 - Carey,F. A.

A1 - Black,R. J.

A1 - Birrell,J.

A1 - Fraser,C. G.

A1 - Steele,R. J. C.

AU - Libby,G.

AU - Brewster,D. H.

AU - McClements,P. L.

AU - Carey,F. A.

AU - Black,R. J.

AU - Birrell,J.

AU - Fraser,C. G.

AU - Steele,R. J. C.

PY - 2012/7/10

Y1 - 2012/7/10

N2 - Background:Randomised trials show reduced colorectal cancer (CRC) mortality with faecal occult blood testing (FOBT). This outcome is now examined in a routine, population-based, screening programme.Methods:Three biennial rounds of the UK CRC screening pilot were completed in Scotland (2000-2007) before the roll out of a national programme. All residents (50-69 years) in the three pilot Health Boards were invited for screening. They received a FOBT test by post to complete at home and return for analysis. Positive tests were followed up with colonoscopy. Controls, selected from non-pilot Health Boards, were matched by age, gender, and deprivation and assigned the invitation date of matched invitee. Follow-up was from invitation date to 31 December 2009 or date of death if earlier.Results:There were 379?655 people in each group (median age 55.6 years, 51.6% male). Participation was 60.6%. There were 961 (0.25%) CRC deaths in invitees, 1056 (0.28%) in controls, rate ratio (RR) 0.90 (95% confidence interval (CI) 0.83-0.99) overall and 0.73 (95% CI 0.65-0.82) for participants. Non-participants had increased CRC mortality compared with controls, RR 1.21 (95% CI 1.06-1.38).Conclusion:There was a 10% relative reduction in CRC mortality in a routine screening programme, rising to 27% in participants.British Journal of Cancer advance online publication, 26 June 2012; doi:10.1038/bjc.2012.277 www.bjcancer.com.

AB - Background:Randomised trials show reduced colorectal cancer (CRC) mortality with faecal occult blood testing (FOBT). This outcome is now examined in a routine, population-based, screening programme.Methods:Three biennial rounds of the UK CRC screening pilot were completed in Scotland (2000-2007) before the roll out of a national programme. All residents (50-69 years) in the three pilot Health Boards were invited for screening. They received a FOBT test by post to complete at home and return for analysis. Positive tests were followed up with colonoscopy. Controls, selected from non-pilot Health Boards, were matched by age, gender, and deprivation and assigned the invitation date of matched invitee. Follow-up was from invitation date to 31 December 2009 or date of death if earlier.Results:There were 379?655 people in each group (median age 55.6 years, 51.6% male). Participation was 60.6%. There were 961 (0.25%) CRC deaths in invitees, 1056 (0.28%) in controls, rate ratio (RR) 0.90 (95% confidence interval (CI) 0.83-0.99) overall and 0.73 (95% CI 0.65-0.82) for participants. Non-participants had increased CRC mortality compared with controls, RR 1.21 (95% CI 1.06-1.38).Conclusion:There was a 10% relative reduction in CRC mortality in a routine screening programme, rising to 27% in participants.British Journal of Cancer advance online publication, 26 June 2012; doi:10.1038/bjc.2012.277 www.bjcancer.com.

UR - http://www.scopus.com/inward/record.url?scp=84863722897&partnerID=8YFLogxK

U2 - 10.1038/bjc.2012.277

DO - 10.1038/bjc.2012.277

M1 - Article

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 2

VL - 107

SP - 255

EP - 259

ER -

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