The mechanisms underlying primitive streak formation in the chick embryo. / Chuai, Manli; Weijer, Cornelis J.
Multiscale modeling of developmental systems. ed. / Santiago Schnell; Philip K. Maini; Stuart A. Newman; Timothy J. Newman. London : Academic Press, 2008. p. 135-156 (Current topics in developmental biology ).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - The mechanisms underlying primitive streak formation in the chick embryo
A1 - Chuai,Manli
A1 - Weijer,Cornelis J.
AU - Chuai,Manli
AU - Weijer,Cornelis J.
PB - Academic Press
CY - London
PY - 2008
Y1 - 2008
N2 - <p>Formation of the primitive streak is one of the key events in the early development of amniote embryos. The streak is the site where during gastrulation the mesendoderm cells ingress to take up their correct topographical positions in the embryo. The process of streak formation can be conveniently observed in the chick embryo, where the streak forms as an accumulation of cells in the epiblast in the posterior pole of the embryo and extends subsequently in anterior direction until it covers 80% of the epiblast. A prerequisite for streak formation is the differentiation of mesoderm, which is induced in the epiblast at the interface between the posterior Area Opaca and Area Pellucida in a sickle shaped domain overlying Koller's sickle. Current views on the molecular mechanisms of mesoderm induction by inducing signals from the Area Opaca and inhibitory signals from the hypoblast are briefly discussed. During streak formation the sickle of mesoderm cells transforms into an elongated structure in the central midline of the embryo. We discuss possible cellular mechanisms underlying this process, such as oriented cell division, cell-cell intercalation, chemotactic cell movement in response to attractive and repulsive signals and a combination of chemotaxis and contact following. We review current experimental evidence in favor and against these different hypotheses and outline some the outstanding questions. Since many of the interactions between cells signaling and moving are dynamic and nonlinear in nature they will require detailed modeling and computer simulations to be understood in detail. (c) 2008, Elsevier Inc.</p>
AB - <p>Formation of the primitive streak is one of the key events in the early development of amniote embryos. The streak is the site where during gastrulation the mesendoderm cells ingress to take up their correct topographical positions in the embryo. The process of streak formation can be conveniently observed in the chick embryo, where the streak forms as an accumulation of cells in the epiblast in the posterior pole of the embryo and extends subsequently in anterior direction until it covers 80% of the epiblast. A prerequisite for streak formation is the differentiation of mesoderm, which is induced in the epiblast at the interface between the posterior Area Opaca and Area Pellucida in a sickle shaped domain overlying Koller's sickle. Current views on the molecular mechanisms of mesoderm induction by inducing signals from the Area Opaca and inhibitory signals from the hypoblast are briefly discussed. During streak formation the sickle of mesoderm cells transforms into an elongated structure in the central midline of the embryo. We discuss possible cellular mechanisms underlying this process, such as oriented cell division, cell-cell intercalation, chemotactic cell movement in response to attractive and repulsive signals and a combination of chemotaxis and contact following. We review current experimental evidence in favor and against these different hypotheses and outline some the outstanding questions. Since many of the interactions between cells signaling and moving are dynamic and nonlinear in nature they will require detailed modeling and computer simulations to be understood in detail. (c) 2008, Elsevier Inc.</p>
KW - Marginal zone
KW - Cell migration
KW - Morphogenetic movements
KW - Beta catenin
KW - Expression
KW - Blastoderm
KW - Induction
KW - Gastrulation
KW - Axis
KW - VG1
U2 - 10.1016/S0070-2153(07)81004-0
DO - 10.1016/S0070-2153(07)81004-0
M1 - Chapter
SN - 9780123742537
BT - Multiscale modeling of developmental systems
T2 - Multiscale modeling of developmental systems
A2 - Newman,Timothy J.
ED - Newman,Timothy J.
T3 - Current topics in developmental biology
T3 - en_GB
SP - 135
EP - 156
ER -