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The mechanisms underlying primitive streak formation in the chick embryo

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The mechanisms underlying primitive streak formation in the chick embryo. / Chuai, Manli; Weijer, Cornelis J.

Multiscale modeling of developmental systems. ed. / Santiago Schnell; Philip K. Maini; Stuart A. Newman; Timothy J. Newman. London : Academic Press, 2008. p. 135-156 (Current topics in developmental biology ; Vol. 81).

Research output: Chapter in Book/Report/Conference proceedingChapter

Harvard

Chuai, M & Weijer, CJ 2008, 'The mechanisms underlying primitive streak formation in the chick embryo'. in S Schnell, PK Maini, SA Newman & TJ Newman (eds), Multiscale modeling of developmental systems. Current topics in developmental biology , vol. 81, Academic Press, London, pp. 135-156., 10.1016/S0070-2153(07)81004-0

APA

Chuai, M., & Weijer, C. J. (2008). The mechanisms underlying primitive streak formation in the chick embryo. In S. Schnell, P. K. Maini, S. A. Newman, & T. J. Newman (Eds.), Multiscale modeling of developmental systems. (pp. 135-156). (Current topics in developmental biology ; Vol. 81). London: Academic Press. 10.1016/S0070-2153(07)81004-0

Vancouver

Chuai M, Weijer CJ. The mechanisms underlying primitive streak formation in the chick embryo. In Schnell S, Maini PK, Newman SA, Newman TJ, editors, Multiscale modeling of developmental systems. London: Academic Press. 2008. p. 135-156. (Current topics in developmental biology ). Available from: 10.1016/S0070-2153(07)81004-0

Author

Chuai, Manli; Weijer, Cornelis J. / The mechanisms underlying primitive streak formation in the chick embryo.

Multiscale modeling of developmental systems. ed. / Santiago Schnell; Philip K. Maini; Stuart A. Newman; Timothy J. Newman. London : Academic Press, 2008. p. 135-156 (Current topics in developmental biology ; Vol. 81).

Research output: Chapter in Book/Report/Conference proceedingChapter

Bibtex - Download

@inbook{d824b3ad2cf94dc4901154db9868e91a,
title = "The mechanisms underlying primitive streak formation in the chick embryo",
keywords = "Marginal zone, Cell migration, Morphogenetic movements, Beta catenin, Expression, Blastoderm, Induction, Gastrulation, Axis, VG1",
author = "Manli Chuai and Weijer, {Cornelis J.}",
year = "2008",
doi = "10.1016/S0070-2153(07)81004-0",
editor = "Santiago Schnell and Maini, {Philip K.} and Newman, {Stuart A.} and Newman, {Timothy J.}",
isbn = "9780123742537",
series = "Current topics in developmental biology",
pages = "135-156",
booktitle = "Multiscale modeling of developmental systems",

}

RIS (suitable for import to EndNote) - Download

TY - CHAP

T1 - The mechanisms underlying primitive streak formation in the chick embryo

A1 - Chuai,Manli

A1 - Weijer,Cornelis J.

AU - Chuai,Manli

AU - Weijer,Cornelis J.

PB - Academic Press

CY - London

PY - 2008

Y1 - 2008

N2 - <p>Formation of the primitive streak is one of the key events in the early development of amniote embryos. The streak is the site where during gastrulation the mesendoderm cells ingress to take up their correct topographical positions in the embryo. The process of streak formation can be conveniently observed in the chick embryo, where the streak forms as an accumulation of cells in the epiblast in the posterior pole of the embryo and extends subsequently in anterior direction until it covers 80% of the epiblast. A prerequisite for streak formation is the differentiation of mesoderm, which is induced in the epiblast at the interface between the posterior Area Opaca and Area Pellucida in a sickle shaped domain overlying Koller's sickle. Current views on the molecular mechanisms of mesoderm induction by inducing signals from the Area Opaca and inhibitory signals from the hypoblast are briefly discussed. During streak formation the sickle of mesoderm cells transforms into an elongated structure in the central midline of the embryo. We discuss possible cellular mechanisms underlying this process, such as oriented cell division, cell-cell intercalation, chemotactic cell movement in response to attractive and repulsive signals and a combination of chemotaxis and contact following. We review current experimental evidence in favor and against these different hypotheses and outline some the outstanding questions. Since many of the interactions between cells signaling and moving are dynamic and nonlinear in nature they will require detailed modeling and computer simulations to be understood in detail. (c) 2008, Elsevier Inc.</p>

AB - <p>Formation of the primitive streak is one of the key events in the early development of amniote embryos. The streak is the site where during gastrulation the mesendoderm cells ingress to take up their correct topographical positions in the embryo. The process of streak formation can be conveniently observed in the chick embryo, where the streak forms as an accumulation of cells in the epiblast in the posterior pole of the embryo and extends subsequently in anterior direction until it covers 80% of the epiblast. A prerequisite for streak formation is the differentiation of mesoderm, which is induced in the epiblast at the interface between the posterior Area Opaca and Area Pellucida in a sickle shaped domain overlying Koller's sickle. Current views on the molecular mechanisms of mesoderm induction by inducing signals from the Area Opaca and inhibitory signals from the hypoblast are briefly discussed. During streak formation the sickle of mesoderm cells transforms into an elongated structure in the central midline of the embryo. We discuss possible cellular mechanisms underlying this process, such as oriented cell division, cell-cell intercalation, chemotactic cell movement in response to attractive and repulsive signals and a combination of chemotaxis and contact following. We review current experimental evidence in favor and against these different hypotheses and outline some the outstanding questions. Since many of the interactions between cells signaling and moving are dynamic and nonlinear in nature they will require detailed modeling and computer simulations to be understood in detail. (c) 2008, Elsevier Inc.</p>

KW - Marginal zone

KW - Cell migration

KW - Morphogenetic movements

KW - Beta catenin

KW - Expression

KW - Blastoderm

KW - Induction

KW - Gastrulation

KW - Axis

KW - VG1

U2 - 10.1016/S0070-2153(07)81004-0

DO - 10.1016/S0070-2153(07)81004-0

M1 - Chapter

SN - 9780123742537

BT - Multiscale modeling of developmental systems

T2 - Multiscale modeling of developmental systems

A2 - Newman,Timothy J.

ED - Newman,Timothy J.

T3 - Current topics in developmental biology

T3 - en_GB

SP - 135

EP - 156

ER -

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