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The Nrf2 transcription factor regulates basal expression of class Alpha and class Mu glutathione S-transferases in the mouse, but not necessarily their induction by cancer chemopreventive agents

The Nrf2 transcription factor regulates basal expression of class Alpha and class Mu glutathione S-transferases in the mouse, but not necessarily their induction by cancer chemopreventive agents

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Original languageEnglish
Pages291-294
Number of pages4
JournalChemico-Biological Interactions
Journal publication date28 Feb 2001
Volume133
Issue1-3
DOIs
StatePublished

Abstract

Nrf2 controls the basal expression of genes regulated through the antioxidant responsive element (ARF). It also contributes to the inducible expression of certain members of the ARE-gene battery. Under normal dietary conditions, the expression of class Alpha and class Mu glutathione S-transferase (GST) isoenzymes and NAD(P)H:quinone oxidoreductase (NQO) in the liver and small intestine is reduced significantly in nrf 2 (-/-) mice. Administration of chemopreventive agents to wildtype mice can result in marked induction of hepatic and intestinal GST and NQO. However, the extent of induction of these detoxication enzymes in the nrf 2 knockout mouse is variable, suggesting gene-specific effects. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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