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The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition

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The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition. / Malekkou, Anna; Lederer, Carsten W.; Lamond, Angus I.; Santama, Niovi.

In: FEBS Letters, Vol. 584, No. 22, 19.11.2010, p. 4559-4564.

Research output: Contribution to journalArticle

Harvard

Malekkou, A, Lederer, CW, Lamond, AI & Santama, N 2010, 'The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition' FEBS Letters, vol 584, no. 22, pp. 4559-4564.

APA

Malekkou, A., Lederer, C. W., Lamond, A. I., & Santama, N. (2010). The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition. FEBS Letters, 584(22), 4559-4564doi: 10.1016/j.febslet.2010.10.044

Vancouver

Malekkou A, Lederer CW, Lamond AI, Santama N. The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition. FEBS Letters. 2010 Nov 19;584(22):4559-4564.

Author

Malekkou, Anna; Lederer, Carsten W.; Lamond, Angus I.; Santama, Niovi / The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition.

In: FEBS Letters, Vol. 584, No. 22, 19.11.2010, p. 4559-4564.

Research output: Contribution to journalArticle

Bibtex - Download

@article{e35bde6830ff4f35a1a97a48b3ce55f6,
title = "The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition",
author = "Anna Malekkou and Lederer, {Carsten W.} and Lamond, {Angus I.} and Niovi Santama",
year = "2010",
volume = "584",
number = "22",
pages = "4559--4564",
journal = "FEBS Letters",
issn = "0014-5793",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition

A1 - Malekkou,Anna

A1 - Lederer,Carsten W.

A1 - Lamond,Angus I.

A1 - Santama,Niovi

AU - Malekkou,Anna

AU - Lederer,Carsten W.

AU - Lamond,Angus I.

AU - Santama,Niovi

PY - 2010/11/19

Y1 - 2010/11/19

N2 - <p>hCINAP is an atypical nucleoplasmic enzyme, combining structural features of adenylate kinases and ATPases, which exhibits dual enzymatic activity. It interacts with the Cajal Body marker coilin and its level of expression and enzymatic activity influence Cajal Body numbers. Here we show that upon specific transcriptional inhibition of RNA pol.II, hCINAP segregates in perinuclear caps identified as Dark Nucleolar Caps (DNCs). These are distinct from perinucleolar caps where coilin and fibrillarin (both Cajal Body components) accumulate. In DNCs, hCINAP co-localizes with Paraspeckle Protein (PSP1) and also co-segregates with PSP1, and not coilin, in nuclear and nucleolar foci upon UV irradiation.</p><p>Structured summary:</p><p>MINT-8048545: hCINAP (uniprotkb:Q9Y3D8) and PSP1 (uniprotkb:Q8WXF1) colocalize (MI:0403) by fluorescence microscopy (MI: 0416) (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.</p>

AB - <p>hCINAP is an atypical nucleoplasmic enzyme, combining structural features of adenylate kinases and ATPases, which exhibits dual enzymatic activity. It interacts with the Cajal Body marker coilin and its level of expression and enzymatic activity influence Cajal Body numbers. Here we show that upon specific transcriptional inhibition of RNA pol.II, hCINAP segregates in perinuclear caps identified as Dark Nucleolar Caps (DNCs). These are distinct from perinucleolar caps where coilin and fibrillarin (both Cajal Body components) accumulate. In DNCs, hCINAP co-localizes with Paraspeckle Protein (PSP1) and also co-segregates with PSP1, and not coilin, in nuclear and nucleolar foci upon UV irradiation.</p><p>Structured summary:</p><p>MINT-8048545: hCINAP (uniprotkb:Q9Y3D8) and PSP1 (uniprotkb:Q8WXF1) colocalize (MI:0403) by fluorescence microscopy (MI: 0416) (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.</p>

KW - Nuclear organization

KW - Cajal Body

KW - Coilin

KW - Paraspeckle Protein 1

KW - Paraspeckle

KW - NUCLEOLAR CAPS

KW - COILED BODIES

KW - CAJAL BODIES

KW - BODY

KW - DIFFERENTIATION

KW - REORGANIZATION

KW - PARASPECKLES

KW - ASSOCIATION

U2 - 10.1016/j.febslet.2010.10.044

DO - 10.1016/j.febslet.2010.10.044

M1 - Article

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 22

VL - 584

SP - 4559

EP - 4564

ER -

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