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The prognostic value of a 7-week high sensitivity troponin T level after an acute coronary syndrome

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The prognostic value of a 7-week high sensitivity troponin T level after an acute coronary syndrome. / Ang, D.S.C.; Kao, M.P.C.; Dow, E.; Lang, C.; Struthers, A.

In: Heart, Vol. 98, No. 15, 2012, p. 1160-5.

Research output: Contribution to journalArticle

Harvard

Ang, DSC, Kao, MPC, Dow, E, Lang, C & Struthers, A 2012, 'The prognostic value of a 7-week high sensitivity troponin T level after an acute coronary syndrome' Heart, vol 98, no. 15, pp. 1160-5., 10.1136/heartjnl-2012-301635

APA

Ang, D. S. C., Kao, M. P. C., Dow, E., Lang, C., & Struthers, A. (2012). The prognostic value of a 7-week high sensitivity troponin T level after an acute coronary syndrome. Heart, 98(15), 1160-5. 10.1136/heartjnl-2012-301635

Vancouver

Ang DSC, Kao MPC, Dow E, Lang C, Struthers A. The prognostic value of a 7-week high sensitivity troponin T level after an acute coronary syndrome. Heart. 2012;98(15):1160-5. Available from: 10.1136/heartjnl-2012-301635

Author

Ang, D.S.C.; Kao, M.P.C.; Dow, E.; Lang, C.; Struthers, A. / The prognostic value of a 7-week high sensitivity troponin T level after an acute coronary syndrome.

In: Heart, Vol. 98, No. 15, 2012, p. 1160-5.

Research output: Contribution to journalArticle

Bibtex - Download

@article{ea7cc75c2e8d479cbb107ef4f457d841,
title = "The prognostic value of a 7-week high sensitivity troponin T level after an acute coronary syndrome",
author = "D.S.C. Ang and M.P.C. Kao and E. Dow and C. Lang and A. Struthers",
year = "2012",
doi = "10.1136/heartjnl-2012-301635",
volume = "98",
number = "15",
pages = "1160--5",
journal = "Heart",
issn = "1355-6037",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - The prognostic value of a 7-week high sensitivity troponin T level after an acute coronary syndrome

A1 - Ang,D.S.C.

A1 - Kao,M.P.C.

A1 - Dow,E.

A1 - Lang,C.

A1 - Struthers,A.

AU - Ang,D.S.C.

AU - Kao,M.P.C.

AU - Dow,E.

AU - Lang,C.

AU - Struthers,A.

PY - 2012

Y1 - 2012

N2 - Objective: The role of high sensitivity troponin T (hs-TnT) in the convalescence phase after an acute coronary syndrome (ACS) is unknown. The authors aim to assess the prognostic utility of a single hs-TnT level at 7-week post-ACS. Second, the authors evaluated whether any serial changes in hs-TnT between the index admission and 7 weeks post-ACS had any link with the prognosis. Third, the authors assessed whether the prognostic utility of hs-TnT is independent of various echocardiographic abnormalities. Methods: The authors measured hs-TnT levels in 326 consecutive patients at 7 weeks after an ACS event. The composite end point of death from any cause or acute myocardial infarction was evaluated over a median duration of 30 months. Results: A high 7-week hs-TnT (>14 ng/l) predicted adverse clinical outcomes independent of conventional risk factors, left ventricular dysfunction and left ventricular hypertrophy on echocardiography (adjusted RR: 2.69 (95% CI 1.45 to 5.00)). Patients with persistent hs-TnT elevation at 7 weeks were also at an increased risk of cardiovascular events compared with those with an initial high hs-TnT which then normalised (unadjusted RR 3.39 (95% CI 2.02 to 5.68)). Conclusion: The authors have demonstrated the prognostic utility of a single 7-week hs-TnT measurement in routine ACS patients and that it could be used to assist medium term risk stratification in this patient cohort. In addition, the authors also showed that hs-TnT predicted long-term adverse prognosis independent of various echo parameters. Future studies should evaluate whether tailoring specific treatment interventions to higher risk individuals as identified by an elevated hs-TnT during the convalescence phase of ACS would improve clinical outcomes. Copyright Article author (or their employer) 2012.

AB - Objective: The role of high sensitivity troponin T (hs-TnT) in the convalescence phase after an acute coronary syndrome (ACS) is unknown. The authors aim to assess the prognostic utility of a single hs-TnT level at 7-week post-ACS. Second, the authors evaluated whether any serial changes in hs-TnT between the index admission and 7 weeks post-ACS had any link with the prognosis. Third, the authors assessed whether the prognostic utility of hs-TnT is independent of various echocardiographic abnormalities. Methods: The authors measured hs-TnT levels in 326 consecutive patients at 7 weeks after an ACS event. The composite end point of death from any cause or acute myocardial infarction was evaluated over a median duration of 30 months. Results: A high 7-week hs-TnT (>14 ng/l) predicted adverse clinical outcomes independent of conventional risk factors, left ventricular dysfunction and left ventricular hypertrophy on echocardiography (adjusted RR: 2.69 (95% CI 1.45 to 5.00)). Patients with persistent hs-TnT elevation at 7 weeks were also at an increased risk of cardiovascular events compared with those with an initial high hs-TnT which then normalised (unadjusted RR 3.39 (95% CI 2.02 to 5.68)). Conclusion: The authors have demonstrated the prognostic utility of a single 7-week hs-TnT measurement in routine ACS patients and that it could be used to assist medium term risk stratification in this patient cohort. In addition, the authors also showed that hs-TnT predicted long-term adverse prognosis independent of various echo parameters. Future studies should evaluate whether tailoring specific treatment interventions to higher risk individuals as identified by an elevated hs-TnT during the convalescence phase of ACS would improve clinical outcomes. Copyright Article author (or their employer) 2012.

UR - http://www.scopus.com/inward/record.url?scp=84861980128&partnerID=8YFLogxK

U2 - 10.1136/heartjnl-2012-301635

DO - 10.1136/heartjnl-2012-301635

M1 - Article

JO - Heart

JF - Heart

SN - 1355-6037

IS - 15

VL - 98

SP - 1160

EP - 1165

ER -

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