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The RNA polymerase I transcription machinery

The RNA polymerase I transcription machinery

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Original languageEnglish
Title of host publicationTranscription
Subtitle of host publicationpapers from the Biochemical Society symposium no. 73, held at Imperial College, London, April 2005
EditorsS. Roberts, R. Weinzierl, R. White
Place of PublicationLondon
PublisherPortland Press Ltd.
Number of pages14
ISBN (Print)1855781638
StatePublished - 2006
EventBiochemical Society Annual Symposium ‘Transcription UK 2005’ - London, United Kingdom

Publication series

NameBiochemical Society symposia
ISSN (Print)0067-8964


ConferenceBiochemical Society Annual Symposium ‘Transcription UK 2005’
CountryUnited Kingdom
Internet address


The rRNAs constitute the catalytic and structural components of the ribosome, the protein synthesis machinery of cells. The level of rRNA synthesis, mediated by Pol I (RNA polymerise I), therefore has a major impact on the life and destiny of a cell. In order to elucidate how cells achieve the stringent control of Pol I transcription, matching the supply of rRNA to demand under different cellular growth conditions, it is essential to understand the components and mechanics of the Pol I transcription machinery. In this review, we discuss: (1) the molecular composition and functions of the Pol I enzyme complex and the two main Pol I transcription factors, SL1 (selectivity factor 1) and UBF (upstream binding factor); (ii) the interplay between these factors during pre-initiation complex formation at the rDNA promoter in mammalian cells; and (iii) the cellular control of the Pol I transcription machinery.

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