Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
| Original language | English |
|---|---|
| Title | Transcription |
| Subtitle | papers from the Biochemical Society symposium no. 73, held at Imperial College, London, April 2005 |
| Editors | S. Roberts, R. Weinzierl, R. White |
| Place of publication | London |
| Publisher | Portland Press Ltd |
| Publication date | 2006 |
| Pages | 203-216 |
| Number of pages | 14 |
| ISBN (Print) | 1855781638 |
| State | Published |
| Name | Biochemical Society symposia |
|---|---|
| Volume | 73 |
| ISSN (Print) | 0067-8964 |
| Conference | Biochemical Society Annual Symposium ‘Transcription UK 2005’ |
|---|---|
| Country | United Kingdom |
| City | London |
| Period | 13/04/05 → 15/04/05 |
| Other |
The rRNAs constitute the catalytic and structural components of the ribosome, the protein synthesis machinery of cells. The level of rRNA synthesis, mediated by Pol I (RNA polymerise I), therefore has a major impact on the life and destiny of a cell. In order to elucidate how cells achieve the stringent control of Pol I transcription, matching the supply of rRNA to demand under different cellular growth conditions, it is essential to understand the components and mechanics of the Pol I transcription machinery. In this review, we discuss: (1) the molecular composition and functions of the Pol I enzyme complex and the two main Pol I transcription factors, SL1 (selectivity factor 1) and UBF (upstream binding factor); (ii) the interplay between these factors during pre-initiation complex formation at the rDNA promoter in mammalian cells; and (iii) the cellular control of the Pol I transcription machinery.
Activity: Conference participation › Participation in conference
Activity: Conference participation › Participation in conference