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The RNA polymerase I transcription machinery

The RNA polymerase I transcription machinery

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Original languageEnglish
Title of host publicationTranscription
Subtitle of host publicationpapers from the Biochemical Society symposium no. 73, held at Imperial College, London, April 2005
EditorsS. Roberts, R. Weinzierl, R. White
Place of publicationLondon
PublisherPortland Press Ltd
Publication date2006
Pages203-216
Number of pages14
ISBN (Print)1855781638
StatePublished

Publication series

NameBiochemical Society symposia
Volume73
ISSN (Print)0067-8964

Conference

ConferenceBiochemical Society Annual Symposium ‘Transcription UK 2005’
CountryUnited Kingdom
CityLondon
Period13/04/0515/04/05
Internet addresshttp://www.biochemistry.org/Conferences/AllConferences/tabid/379/View/GeneralInfo/Filter/64%2012AS/MeetingNo/SA035/Default.aspx

Abstract

The rRNAs constitute the catalytic and structural components of the ribosome, the protein synthesis machinery of cells. The level of rRNA synthesis, mediated by Pol I (RNA polymerise I), therefore has a major impact on the life and destiny of a cell. In order to elucidate how cells achieve the stringent control of Pol I transcription, matching the supply of rRNA to demand under different cellular growth conditions, it is essential to understand the components and mechanics of the Pol I transcription machinery. In this review, we discuss: (1) the molecular composition and functions of the Pol I enzyme complex and the two main Pol I transcription factors, SL1 (selectivity factor 1) and UBF (upstream binding factor); (ii) the interplay between these factors during pre-initiation complex formation at the rDNA promoter in mammalian cells; and (iii) the cellular control of the Pol I transcription machinery.

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