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The role of GABAA receptor biogenesis, structure and function in epilepsy

The role of GABAA receptor biogenesis, structure and function in epilepsy

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Authors

  • S. Mizielinska
  • S. Greenwood
  • C. N. Connolly

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Info

Original languageEnglish
Pages863-867
Number of pages5
JournalBiochemical Society Transactions
Journal publication date2006
Journal number5
Volume34
DOIs
StatePublished

Abstract

Maintaining the correct balance in neuronal activation is of paramount importance to normal brain function. imbalances due to changes in excitation or inhibition can lead to a variety of disorders ranging from the clinically extreme (e.g. epilepsy) to the more subtle (e.g. anxiety). in the brain, the most common inhibitory synapses are regulated by GABA(A) (gamma-aminobutyric acid type A) receptors, a role commensurate with their importance as therapeutic targets. Remarkably, we still know relatively little about GABAA receptor biogenesis. Receptors are constructed as pentameric ion channels, with alpha and beta subunits being the minimal requirement, and the incorporation of a gamma subunit being necessary for benzodiazepine modulation and synaptic targeting. insights have been provided by the discovery of several specific assembly signals within different GABA(A) receptor subunits. Moreover, a number of recent studies on GABA(A) receptor mutations associated with epilepsy have further enhanced our understanding of GABA(A) receptor biogenesis, structure and function.

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