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The role of GABAA receptor biogenesis, structure and function in epilepsy

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The role of GABAA receptor biogenesis, structure and function in epilepsy. / Mizielinska, S.; Greenwood, S.; Connolly, C. N.

In: Biochemical Society Transactions, Vol. 34, No. 5, 2006, p. 863-867.

Research output: Contribution to journalArticle

Harvard

Mizielinska, S, Greenwood, S & Connolly, CN 2006, 'The role of GABAA receptor biogenesis, structure and function in epilepsy' Biochemical Society Transactions, vol 34, no. 5, pp. 863-867.

APA

Mizielinska, S., Greenwood, S., & Connolly, C. N. (2006). The role of GABAA receptor biogenesis, structure and function in epilepsy. Biochemical Society Transactions, 34(5), 863-867doi: 10.1042/BST0340863

Vancouver

Mizielinska S, Greenwood S, Connolly CN. The role of GABAA receptor biogenesis, structure and function in epilepsy. Biochemical Society Transactions. 2006;34(5):863-867.

Author

Mizielinska, S.; Greenwood, S.; Connolly, C. N. / The role of GABAA receptor biogenesis, structure and function in epilepsy.

In: Biochemical Society Transactions, Vol. 34, No. 5, 2006, p. 863-867.

Research output: Contribution to journalArticle

Bibtex - Download

@article{dd29b42c10c24658ae2ad60e2b1adf57,
title = "The role of GABA<sub>A </sub>receptor biogenesis, structure and function in epilepsy",
author = "S. Mizielinska and S. Greenwood and Connolly, {C. N.}",
year = "2006",
volume = "34",
number = "5",
pages = "863--867",
journal = "Biochemical Society Transactions",
issn = "0300-5127",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - The role of GABA<sub>A </sub>receptor biogenesis, structure and function in epilepsy

A1 - Mizielinska,S.

A1 - Greenwood,S.

A1 - Connolly,C. N.

AU - Mizielinska,S.

AU - Greenwood,S.

AU - Connolly,C. N.

PY - 2006

Y1 - 2006

N2 - <p>Maintaining the correct balance in neuronal activation is of paramount importance to normal brain function. imbalances due to changes in excitation or inhibition can lead to a variety of disorders ranging from the clinically extreme (e.g. epilepsy) to the more subtle (e.g. anxiety). in the brain, the most common inhibitory synapses are regulated by GABA(A) (gamma-aminobutyric acid type A) receptors, a role commensurate with their importance as therapeutic targets. Remarkably, we still know relatively little about GABAA receptor biogenesis. Receptors are constructed as pentameric ion channels, with alpha and beta subunits being the minimal requirement, and the incorporation of a gamma subunit being necessary for benzodiazepine modulation and synaptic targeting. insights have been provided by the discovery of several specific assembly signals within different GABA(A) receptor subunits. Moreover, a number of recent studies on GABA(A) receptor mutations associated with epilepsy have further enhanced our understanding of GABA(A) receptor biogenesis, structure and function.</p>

AB - <p>Maintaining the correct balance in neuronal activation is of paramount importance to normal brain function. imbalances due to changes in excitation or inhibition can lead to a variety of disorders ranging from the clinically extreme (e.g. epilepsy) to the more subtle (e.g. anxiety). in the brain, the most common inhibitory synapses are regulated by GABA(A) (gamma-aminobutyric acid type A) receptors, a role commensurate with their importance as therapeutic targets. Remarkably, we still know relatively little about GABAA receptor biogenesis. Receptors are constructed as pentameric ion channels, with alpha and beta subunits being the minimal requirement, and the incorporation of a gamma subunit being necessary for benzodiazepine modulation and synaptic targeting. insights have been provided by the discovery of several specific assembly signals within different GABA(A) receptor subunits. Moreover, a number of recent studies on GABA(A) receptor mutations associated with epilepsy have further enhanced our understanding of GABA(A) receptor biogenesis, structure and function.</p>

U2 - 10.1042/BST0340863

DO - 10.1042/BST0340863

M1 - Article

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

IS - 5

VL - 34

SP - 863

EP - 867

ER -

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