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Towards a definition of refractory neuropathic pain for epidemiological research

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Towards a definition of refractory neuropathic pain for epidemiological research : an international Delphi survey of experts. / Smith, Blair H. (Lead / Corresponding author); Torrance, Nicola; Ferguson, Janice A.; Bennett, Michael I.; Serpell, Michael G.; Dunn, Kate M.

In: BMC Neurology, Vol. 12, 29, 28.05.2012.

Research output: Contribution to journalArticle

Harvard

Smith, BH, Torrance, N, Ferguson, JA, Bennett, MI, Serpell, MG & Dunn, KM 2012, 'Towards a definition of refractory neuropathic pain for epidemiological research: an international Delphi survey of experts' BMC Neurology, vol 12, 29.

APA

Smith, B. H., Torrance, N., Ferguson, J. A., Bennett, M. I., Serpell, M. G., & Dunn, K. M. (2012). Towards a definition of refractory neuropathic pain for epidemiological research: an international Delphi survey of experts. BMC Neurology, 12, [29]doi: 10.1186/1471-2377-12-29

Vancouver

Smith BH, Torrance N, Ferguson JA, Bennett MI, Serpell MG, Dunn KM. Towards a definition of refractory neuropathic pain for epidemiological research: an international Delphi survey of experts. BMC Neurology. 2012 May 28;12. 29.

Author

Smith, Blair H. (Lead / Corresponding author); Torrance, Nicola; Ferguson, Janice A.; Bennett, Michael I.; Serpell, Michael G.; Dunn, Kate M. / Towards a definition of refractory neuropathic pain for epidemiological research : an international Delphi survey of experts.

In: BMC Neurology, Vol. 12, 29, 28.05.2012.

Research output: Contribution to journalArticle

Bibtex - Download

@article{f70f42ffb6a24a6ab64c8f1ab439064d,
title = "Towards a definition of refractory neuropathic pain for epidemiological research",
author = "Smith, {Blair H.} and Nicola Torrance and Ferguson, {Janice A.} and Bennett, {Michael I.} and Serpell, {Michael G.} and Dunn, {Kate M.}",
year = "2012",
volume = "12",
journal = "BMC Neurology",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Towards a definition of refractory neuropathic pain for epidemiological research

T2 - an international Delphi survey of experts

A1 - Smith,Blair H.

A1 - Torrance,Nicola

A1 - Ferguson,Janice A.

A1 - Bennett,Michael I.

A1 - Serpell,Michael G.

A1 - Dunn,Kate M.

AU - Smith,Blair H.

AU - Torrance,Nicola

AU - Ferguson,Janice A.

AU - Bennett,Michael I.

AU - Serpell,Michael G.

AU - Dunn,Kate M.

PY - 2012/5/28

Y1 - 2012/5/28

N2 - BACKGROUND: Best current estimates of neuropathic pain (NeuP) prevalence come from studies using various screening detecting pain with probable neuropathic features; the proportion experiencing significant, long-term NeuP, and the proportion not responding to standard treatment are unknown. These "refractory" cases are the most clinically important to detect, being the most severe, requiring specialist treatment.<br/><br/>METHODS: We report an international Delphi survey of experts in NeuP, aiming for consensus on the features required to define, for epidemiological research: (1) neuropathic pain; and (2) when NeuP is "refractory". A web-based questionnaire was developed and data collected from three rounds of questionnaires from nineteen experts.<br/><br/>RESULTS: There was good consensus on essential inclusion of six items to identify NeuP ("prickling, tingling, pins &amp; needles", "pain evoked by light touch", "electric shocks or shooting pain", "hot or burning" pain, "brush allodynia on self-examination", and "relevant history") and on some items that were non-essential. Consensus was also reached on components of a "refractory NeuP" definition: minimum duration (one year); number of trials of drugs of known effectiveness (four); adequate duration of these trials (three months / maximum tolerated); outcomes of treatment (pain severity, quality of life). Further work needs to validate these proposed criteria in general population research.<br/><br/>CONCLUSIONS: This paper presents an international consensus on measuring the epidemiology of refractory neuropathic pain. This will be valuable in reaching an agreed estimate of the prevalence of neuropathic pain, and the first estimate of refractory neuropathic pain prevalence.<br/><br/>

AB - BACKGROUND: Best current estimates of neuropathic pain (NeuP) prevalence come from studies using various screening detecting pain with probable neuropathic features; the proportion experiencing significant, long-term NeuP, and the proportion not responding to standard treatment are unknown. These "refractory" cases are the most clinically important to detect, being the most severe, requiring specialist treatment.<br/><br/>METHODS: We report an international Delphi survey of experts in NeuP, aiming for consensus on the features required to define, for epidemiological research: (1) neuropathic pain; and (2) when NeuP is "refractory". A web-based questionnaire was developed and data collected from three rounds of questionnaires from nineteen experts.<br/><br/>RESULTS: There was good consensus on essential inclusion of six items to identify NeuP ("prickling, tingling, pins &amp; needles", "pain evoked by light touch", "electric shocks or shooting pain", "hot or burning" pain, "brush allodynia on self-examination", and "relevant history") and on some items that were non-essential. Consensus was also reached on components of a "refractory NeuP" definition: minimum duration (one year); number of trials of drugs of known effectiveness (four); adequate duration of these trials (three months / maximum tolerated); outcomes of treatment (pain severity, quality of life). Further work needs to validate these proposed criteria in general population research.<br/><br/>CONCLUSIONS: This paper presents an international consensus on measuring the epidemiology of refractory neuropathic pain. This will be valuable in reaching an agreed estimate of the prevalence of neuropathic pain, and the first estimate of refractory neuropathic pain prevalence.<br/><br/>

KW - Neuropathic pain

KW - Refractory

KW - Epidemiology

KW - Delphi method

KW - Web-based questionnaire

UR - http://www.biomedcentral.com/1471-2377/12/29

U2 - 10.1186/1471-2377-12-29

DO - 10.1186/1471-2377-12-29

M1 - Article

JO - BMC Neurology

JF - BMC Neurology

VL - 12

ER -

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