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Trends in primary care antidepressant prescribing 1995-2007

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Trends in primary care antidepressant prescribing 1995-2007 : a longitudinal population database analysis. / Lockhart, Pauline; Guthrie, Bruce.

In: British Journal of General Practice, Vol. 61, No. 590, 09.2011, p. e565-e572.

Research output: Contribution to journalArticle

Harvard

Lockhart, P & Guthrie, B 2011, 'Trends in primary care antidepressant prescribing 1995-2007: a longitudinal population database analysis' British Journal of General Practice, vol 61, no. 590, pp. e565-e572., 10.3399/bjgp11X593848

APA

Lockhart, P., & Guthrie, B. (2011). Trends in primary care antidepressant prescribing 1995-2007: a longitudinal population database analysis. British Journal of General Practice, 61(590), e565-e572. 10.3399/bjgp11X593848

Vancouver

Lockhart P, Guthrie B. Trends in primary care antidepressant prescribing 1995-2007: a longitudinal population database analysis. British Journal of General Practice. 2011 Sep;61(590):e565-e572. Available from: 10.3399/bjgp11X593848

Author

Lockhart, Pauline; Guthrie, Bruce / Trends in primary care antidepressant prescribing 1995-2007 : a longitudinal population database analysis.

In: British Journal of General Practice, Vol. 61, No. 590, 09.2011, p. e565-e572.

Research output: Contribution to journalArticle

Bibtex - Download

@article{52af30fb373647f6b7f1a47075423a5a,
title = "Trends in primary care antidepressant prescribing 1995-2007: a longitudinal population database analysis",
keywords = "Antidepressant drugs, Family practice, Prescribing patterns, Scotland",
author = "Pauline Lockhart and Bruce Guthrie",
year = "2011",
doi = "10.3399/bjgp11X593848",
volume = "61",
number = "590",
pages = "e565--e572",
journal = "British Journal of General Practice",
issn = "0960-1643",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Trends in primary care antidepressant prescribing 1995-2007

T2 - a longitudinal population database analysis

A1 - Lockhart,Pauline

A1 - Guthrie,Bruce

AU - Lockhart,Pauline

AU - Guthrie,Bruce

PY - 2011/9

Y1 - 2011/9

N2 - Background: Antidepressant prescribing is increasing worldwide, prompting policy interventions and targets to halt the rise. Aim: To examine time trends in GP antidepressant prescribing using patient-level data. Design and setting: Longitudinal population database of all community pharmacy dispensed prescriptions for all 325 000 residents of the Tayside region of Scotland. Method: In each of 3 study years (1995/1996, 2000/2001 and 2006/2007), the volume of antidepressants prescribed was calculated, and numbers of patients prescribed antidepressants in each year, mean treatment duration, and mean dose per patient in that year examined using descriptive statistics. Results: Total drug volume increased threefold between 1995/1996 and 2006/2007, largely driven by increases in selective serotonin reuptake inhibitor (SSRI) prescribing, and laterally also in 'other' antidepressant prescribing. Tricyclic prescribing is static, but low-dose amitriptyline increasingly dominates this drug class. Increased drug volume was initially driven by increasing patient numbers (from 8.0% of the population prescribed at least once in 1995/1996 to 11.9% in 2000/2001) and increased treatment duration (from 170 days in the measurement year to 200). Latterly, drug volume increases are increasingly attributable to longer duration of treatment and higher mean daily dose. Conclusion: The large rise in antidepressant volumes is caused by a complex mixture of more patients being prescribed SSRI and 'other'antidepressants, the use of higher doses, and longer durations of treatment, with the balance changing over time. Tricyclic prescribing is now largely low dose, and probably for conditions other than depression. Interventions to improve the quality of antidepressant prescribing need to be more subtle than blanket targets to reduce the total volume of antidepressants prescribed. ©British Journal of General Practice.

AB - Background: Antidepressant prescribing is increasing worldwide, prompting policy interventions and targets to halt the rise. Aim: To examine time trends in GP antidepressant prescribing using patient-level data. Design and setting: Longitudinal population database of all community pharmacy dispensed prescriptions for all 325 000 residents of the Tayside region of Scotland. Method: In each of 3 study years (1995/1996, 2000/2001 and 2006/2007), the volume of antidepressants prescribed was calculated, and numbers of patients prescribed antidepressants in each year, mean treatment duration, and mean dose per patient in that year examined using descriptive statistics. Results: Total drug volume increased threefold between 1995/1996 and 2006/2007, largely driven by increases in selective serotonin reuptake inhibitor (SSRI) prescribing, and laterally also in 'other' antidepressant prescribing. Tricyclic prescribing is static, but low-dose amitriptyline increasingly dominates this drug class. Increased drug volume was initially driven by increasing patient numbers (from 8.0% of the population prescribed at least once in 1995/1996 to 11.9% in 2000/2001) and increased treatment duration (from 170 days in the measurement year to 200). Latterly, drug volume increases are increasingly attributable to longer duration of treatment and higher mean daily dose. Conclusion: The large rise in antidepressant volumes is caused by a complex mixture of more patients being prescribed SSRI and 'other'antidepressants, the use of higher doses, and longer durations of treatment, with the balance changing over time. Tricyclic prescribing is now largely low dose, and probably for conditions other than depression. Interventions to improve the quality of antidepressant prescribing need to be more subtle than blanket targets to reduce the total volume of antidepressants prescribed. ©British Journal of General Practice.

KW - Antidepressant drugs

KW - Family practice

KW - Prescribing patterns

KW - Scotland

UR - http://www.scopus.com/inward/record.url?scp=83455236602&partnerID=8YFLogxK

U2 - 10.3399/bjgp11X593848

DO - 10.3399/bjgp11X593848

M1 - Article

JO - British Journal of General Practice

JF - British Journal of General Practice

SN - 0960-1643

IS - 590

VL - 61

SP - e565-e572

ER -

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