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Tubular Carcinoma of the Breast: Further Evidence to Support Its Excellent Prognosis

Tubular Carcinoma of the Breast: Further Evidence to Support Its Excellent Prognosis

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Authors

  • Emad A. Rakha
  • Andrew H. S. Lee
  • Andrew J. Evans
  • Sindhu Menon
  • Nancy Y. Assad
  • Zsolt Hodi
  • Douglas Macmillan
  • Roger W. Blamey
  • Ian O. Ellis

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    Info

    Original languageEnglish
    Pages99-104
    Number of pages6
    JournalJournal of Clinical Oncology
    Journal publication date1 Jan 2010
    Volume28
    Issue1
    DOIs
    StatePublished

    Abstract

    Purpose

    Although tubular carcinoma (TC) is known to have a favorable prognosis, it is still unknown whether this subtype represents a distinct type of breast carcinoma or whether it behaves like other low-grade luminal A-type breast carcinomas.

    Methods

    In this study, we performed a retrospective analysis of a large well-characterized series of breast cancers (2,608 carcinomas) to assess the clinicopathologic and molecular features and prognostic value of TC compared with grade 1 ductal carcinomas of the breast.

    Results

    When compared with grade 1 ductal carcinoma (n = 212), TC (n = 102) was more likely to be detected on mammographic screening, had smaller median size, and less frequently showed lymphovascular invasion. Compared with grade 1 ductal carcinoma, TC was associated with longer disease-free survival (chi(2) = 13.25, P < .001) and breast cancer-specific survival (chi(2) = 8.8, P = .003). In this study, none of the patients with TC developed distant metastasis or died from the disease without an intervening recurrence as invasive carcinoma of different histologic type.

    Conclusion

    We conclude that the biologic behavior of TC is excellent and is more favorable than that of grade 1 ductal carcinoma. Patients with TC may be at risk of developing second primary carcinomas in the contralateral breast, which may be of higher grade and poorer potential prognostic outcome. In addition, patients with TC seem to have a close to normal life expectancy, and as a consequence, adjuvant systemic therapy may not be justified in their routine management.

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