Type and maturational status of dendritic cells in cutaneous B cell lymphoproliferative disorders. / Christie, Lesley J.; MacKenzie, Carol; Palmer, Timothy J.; Baker, Lee; Goodlad, John R.
In: Histopathology, Vol. 59, No. 3, 09.2011, p. 421-432.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Type and maturational status of dendritic cells in cutaneous B cell lymphoproliferative disorders
A1 - Christie,Lesley J.
A1 - MacKenzie,Carol
A1 - Palmer,Timothy J.
A1 - Baker,Lee
A1 - Goodlad,John R.
AU - Christie,Lesley J.
AU - MacKenzie,Carol
AU - Palmer,Timothy J.
AU - Baker,Lee
AU - Goodlad,John R.
PY - 2011/9
Y1 - 2011/9
N2 - <p>Aims: B cell cutaneous lymphoid hyperplasia (B-CLH) and cutaneous mucosa-associated lymphoid tissue (MALT) lymphoma represent opposite poles of the same disease spectrum. We explored the hypothesis that dendritic cells (DCs) are central in the generation and regulation of such lesions.</p><p>Methods and results: Immunohistochemistry was used to identify Langerhan cells (LCs), dermal DCs (DDCs) and plasmacytoid DCs (PDCs), as well as mature and alternatively activated DCs, in B-CLH (n = 14) and cutaneous MALT lymphoma (n = 18). PDCs were most numerous in both types of lesion, but there were significantly more PDCs and DDCs and greater numbers of mature DCs in B-CLH. Nevertheless, DCs were still present in cutaneous MALT lymphoma and there were also proportionately more alternatively activated cells.</p><p>Conclusion: Mature DDCs are prime activators of naive T cells and our results suggest that they are likely to be largely responsible for driving the initial proliferation in B-CLH. The results also suggest that PDCs play a central role, and we hypothesize that they dictate the magnitude, duration and direction of the response. In cutaneous MALT lymphoma PDCs are the dominant DC subtype, and may act by damping down the antitumour host immune response, as well as directly stimulating the growth and differentiation of the neoplastic lymphocytes.</p>
AB - <p>Aims: B cell cutaneous lymphoid hyperplasia (B-CLH) and cutaneous mucosa-associated lymphoid tissue (MALT) lymphoma represent opposite poles of the same disease spectrum. We explored the hypothesis that dendritic cells (DCs) are central in the generation and regulation of such lesions.</p><p>Methods and results: Immunohistochemistry was used to identify Langerhan cells (LCs), dermal DCs (DDCs) and plasmacytoid DCs (PDCs), as well as mature and alternatively activated DCs, in B-CLH (n = 14) and cutaneous MALT lymphoma (n = 18). PDCs were most numerous in both types of lesion, but there were significantly more PDCs and DDCs and greater numbers of mature DCs in B-CLH. Nevertheless, DCs were still present in cutaneous MALT lymphoma and there were also proportionately more alternatively activated cells.</p><p>Conclusion: Mature DDCs are prime activators of naive T cells and our results suggest that they are likely to be largely responsible for driving the initial proliferation in B-CLH. The results also suggest that PDCs play a central role, and we hypothesize that they dictate the magnitude, duration and direction of the response. In cutaneous MALT lymphoma PDCs are the dominant DC subtype, and may act by damping down the antitumour host immune response, as well as directly stimulating the growth and differentiation of the neoplastic lymphocytes.</p>
KW - B-cutaneous lymphoid hyperplasia
KW - cutaneous mucosa-associated lymphoid tissue lymphoma
KW - dendritic cells
KW - plasmacytoid dendritic cell
KW - REGULATORY T-CELLS
KW - PRIMARY SJOGRENS-SYNDROME
KW - ANTIGEN-PRESENTING CELLS
KW - MHC CLASS-II
KW - LYMPHOID HYPERPLASIA
KW - HUMAN SKIN
KW - LECTIN RECEPTORS
KW - LANGERHANS CELLS
KW - IN-VITRO
KW - DC-SIGN
U2 - 10.1111/j.1365-2559.2011.03967.x
DO - 10.1111/j.1365-2559.2011.03967.x
M1 - Article
JO - Histopathology
JF - Histopathology
SN - 0309-0167
IS - 3
VL - 59
SP - 421
EP - 432
ER -