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Type and maturational status of dendritic cells in cutaneous B cell lymphoproliferative disorders

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Type and maturational status of dendritic cells in cutaneous B cell lymphoproliferative disorders. / Christie, Lesley J.; MacKenzie, Carol; Palmer, Timothy J.; Baker, Lee; Goodlad, John R.

In: Histopathology, Vol. 59, No. 3, 09.2011, p. 421-432.

Research output: Contribution to journalArticle

Harvard

Christie, LJ, MacKenzie, C, Palmer, TJ, Baker, L & Goodlad, JR 2011, 'Type and maturational status of dendritic cells in cutaneous B cell lymphoproliferative disorders' Histopathology, vol 59, no. 3, pp. 421-432.

APA

Christie, L. J., MacKenzie, C., Palmer, T. J., Baker, L., & Goodlad, J. R. (2011). Type and maturational status of dendritic cells in cutaneous B cell lymphoproliferative disorders. Histopathology, 59(3), 421-432doi: 10.1111/j.1365-2559.2011.03967.x

Vancouver

Christie LJ, MacKenzie C, Palmer TJ, Baker L, Goodlad JR. Type and maturational status of dendritic cells in cutaneous B cell lymphoproliferative disorders. Histopathology. 2011 Sep;59(3):421-432.

Author

Christie, Lesley J.; MacKenzie, Carol; Palmer, Timothy J.; Baker, Lee; Goodlad, John R. / Type and maturational status of dendritic cells in cutaneous B cell lymphoproliferative disorders.

In: Histopathology, Vol. 59, No. 3, 09.2011, p. 421-432.

Research output: Contribution to journalArticle

Bibtex - Download

@article{d74d145365274c948d515dbb8ab69f22,
title = "Type and maturational status of dendritic cells in cutaneous B cell lymphoproliferative disorders",
author = "Christie, {Lesley J.} and Carol MacKenzie and Palmer, {Timothy J.} and Lee Baker and Goodlad, {John R.}",
year = "2011",
volume = "59",
number = "3",
pages = "421--432",
journal = "Histopathology",
issn = "0309-0167",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Type and maturational status of dendritic cells in cutaneous B cell lymphoproliferative disorders

A1 - Christie,Lesley J.

A1 - MacKenzie,Carol

A1 - Palmer,Timothy J.

A1 - Baker,Lee

A1 - Goodlad,John R.

AU - Christie,Lesley J.

AU - MacKenzie,Carol

AU - Palmer,Timothy J.

AU - Baker,Lee

AU - Goodlad,John R.

PY - 2011/9

Y1 - 2011/9

N2 - <p>Aims: B cell cutaneous lymphoid hyperplasia (B-CLH) and cutaneous mucosa-associated lymphoid tissue (MALT) lymphoma represent opposite poles of the same disease spectrum. We explored the hypothesis that dendritic cells (DCs) are central in the generation and regulation of such lesions.</p><p>Methods and results: Immunohistochemistry was used to identify Langerhan cells (LCs), dermal DCs (DDCs) and plasmacytoid DCs (PDCs), as well as mature and alternatively activated DCs, in B-CLH (n = 14) and cutaneous MALT lymphoma (n = 18). PDCs were most numerous in both types of lesion, but there were significantly more PDCs and DDCs and greater numbers of mature DCs in B-CLH. Nevertheless, DCs were still present in cutaneous MALT lymphoma and there were also proportionately more alternatively activated cells.</p><p>Conclusion: Mature DDCs are prime activators of naive T cells and our results suggest that they are likely to be largely responsible for driving the initial proliferation in B-CLH. The results also suggest that PDCs play a central role, and we hypothesize that they dictate the magnitude, duration and direction of the response. In cutaneous MALT lymphoma PDCs are the dominant DC subtype, and may act by damping down the antitumour host immune response, as well as directly stimulating the growth and differentiation of the neoplastic lymphocytes.</p>

AB - <p>Aims: B cell cutaneous lymphoid hyperplasia (B-CLH) and cutaneous mucosa-associated lymphoid tissue (MALT) lymphoma represent opposite poles of the same disease spectrum. We explored the hypothesis that dendritic cells (DCs) are central in the generation and regulation of such lesions.</p><p>Methods and results: Immunohistochemistry was used to identify Langerhan cells (LCs), dermal DCs (DDCs) and plasmacytoid DCs (PDCs), as well as mature and alternatively activated DCs, in B-CLH (n = 14) and cutaneous MALT lymphoma (n = 18). PDCs were most numerous in both types of lesion, but there were significantly more PDCs and DDCs and greater numbers of mature DCs in B-CLH. Nevertheless, DCs were still present in cutaneous MALT lymphoma and there were also proportionately more alternatively activated cells.</p><p>Conclusion: Mature DDCs are prime activators of naive T cells and our results suggest that they are likely to be largely responsible for driving the initial proliferation in B-CLH. The results also suggest that PDCs play a central role, and we hypothesize that they dictate the magnitude, duration and direction of the response. In cutaneous MALT lymphoma PDCs are the dominant DC subtype, and may act by damping down the antitumour host immune response, as well as directly stimulating the growth and differentiation of the neoplastic lymphocytes.</p>

KW - B-cutaneous lymphoid hyperplasia

KW - cutaneous mucosa-associated lymphoid tissue lymphoma

KW - dendritic cells

KW - plasmacytoid dendritic cell

KW - REGULATORY T-CELLS

KW - PRIMARY SJOGRENS-SYNDROME

KW - ANTIGEN-PRESENTING CELLS

KW - MHC CLASS-II

KW - LYMPHOID HYPERPLASIA

KW - HUMAN SKIN

KW - LECTIN RECEPTORS

KW - LANGERHANS CELLS

KW - IN-VITRO

KW - DC-SIGN

U2 - 10.1111/j.1365-2559.2011.03967.x

DO - 10.1111/j.1365-2559.2011.03967.x

M1 - Article

JO - Histopathology

JF - Histopathology

SN - 0309-0167

IS - 3

VL - 59

SP - 421

EP - 432

ER -

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