Ultrasound activated nano-encapsulated targeted drug delivery and tumour cell poration
Research output: Chapter in Book/Report/Conference proceeding › Chapter
|Title of host publication||Nano-biotechnology for biomedical and diagnostic research|
|Editors||Eran Zahavy, Arie Ordentlich, Shmuel Yitzhaki, Avigdor Shafferman|
|Number of pages||10|
|State||Published - 2012|
|Name||Advances in Experimental Medicine and Biology|
Recently, ultrasonic drug release has been a focus of many research groups for stimuli responsive drug release. It has been demonstrated that a focused ultrasound (FUS) beam rapidly increases the temperature at the focused tissue area. One potential mechanism of drug targeting is to utilize the induced heat to release or increase penetration of chemotherapy to cancer cells. The efficiency of targeted drug delivery may increase by using FUS beam in conjugation with nano--encapsulated drug carriers.The aim of this study is to investigate the effect of heat and ultrasound on the cellular uptake and therapeutic efficacy of an anticancer drug using Magnetic Resonance Imaging guided Focused Ultrasound (MRgFUS).