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Ultrasound activated nano-encapsulated targeted drug delivery and tumour cell poration

Ultrasound activated nano-encapsulated targeted drug delivery and tumour cell poration

Research output: Chapter in Book/Report/Conference proceedingChapter

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Authors

  • Dana Gourevich
  • Bjoern Gerold
  • Fabian Arditti
  • Doudou Xu
  • Dun Liu
  • Alex Volovick
  • Lijun Wang
  • Yoav Medan
  • Jallal Gnaim
  • Paul Prentice
  • Sandy Cochran
  • Andreas Melzer

Research units

Info

Original languageEnglish
TitleNano-biotechnology for biomedical and diagnostic research
EditorsEran Zahavy, Arie Ordentlich, Shmuel Yitzhaki, Avigdor Shafferman
PublisherSpringer
Publication date2012
Pages135-44
Number of pages10
Volume733
ISBN (Electronic)9789400725553
ISBN (Print)9789400725546
DOIs
StatePublished

Publication series

NameAdvances in Experimental Medicine and Biology
Volume733

Abstract

Recently, ultrasonic drug release has been a focus of many research groups for stimuli responsive drug release. It has been demonstrated that a focused ultrasound (FUS) beam rapidly increases the temperature at the focused tissue area. One potential mechanism of drug targeting is to utilize the induced heat to release or increase penetration of chemotherapy to cancer cells. The efficiency of targeted drug delivery may increase by using FUS beam in conjugation with nano--encapsulated drug carriers.The aim of this study is to investigate the effect of heat and ultrasound on the cellular uptake and therapeutic efficacy of an anticancer drug using Magnetic Resonance Imaging guided Focused Ultrasound (MRgFUS).

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