Ultrasound activated nano-encapsulated targeted drug delivery and tumour cell poration. / Gourevich, Dana; Gerold, Bjoern; Arditti, Fabian; Xu, Doudou; Liu, Dun; Volovick, Alex; Wang, Lijun; Medan, Yoav; Gnaim, Jallal; Prentice, Paul; Cochran, Sandy; Melzer, Andreas.
Nano-biotechnology for biomedical and diagnostic research. ed. / Eran Zahavy; Arie Ordentlich; Shmuel Yitzhaki; Avigdor Shafferman. Vol. 733 Springer, 2012. p. 135-44 (Advances in Experimental Medicine and Biology).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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TY - CHAP
T1 - Ultrasound activated nano-encapsulated targeted drug delivery and tumour cell poration
A1 - Gourevich,Dana
A1 - Gerold,Bjoern
A1 - Arditti,Fabian
A1 - Xu,Doudou
A1 - Liu,Dun
A1 - Volovick,Alex
A1 - Wang,Lijun
A1 - Medan,Yoav
A1 - Gnaim,Jallal
A1 - Prentice,Paul
A1 - Cochran,Sandy
A1 - Melzer,Andreas
AU - Gourevich,Dana
AU - Gerold,Bjoern
AU - Arditti,Fabian
AU - Xu,Doudou
AU - Liu,Dun
AU - Volovick,Alex
AU - Wang,Lijun
AU - Medan,Yoav
AU - Gnaim,Jallal
AU - Prentice,Paul
AU - Cochran,Sandy
AU - Melzer,Andreas
PB - Springer
PY - 2012
Y1 - 2012
N2 - Recently, ultrasonic drug release has been a focus of many research groups for stimuli responsive drug release. It has been demonstrated that a focused ultrasound (FUS) beam rapidly increases the temperature at the focused tissue area. One potential mechanism of drug targeting is to utilize the induced heat to release or increase penetration of chemotherapy to cancer cells. The efficiency of targeted drug delivery may increase by using FUS beam in conjugation with nano--encapsulated drug carriers.The aim of this study is to investigate the effect of heat and ultrasound on the cellular uptake and therapeutic efficacy of an anticancer drug using Magnetic Resonance Imaging guided Focused Ultrasound (MRgFUS).
AB - Recently, ultrasonic drug release has been a focus of many research groups for stimuli responsive drug release. It has been demonstrated that a focused ultrasound (FUS) beam rapidly increases the temperature at the focused tissue area. One potential mechanism of drug targeting is to utilize the induced heat to release or increase penetration of chemotherapy to cancer cells. The efficiency of targeted drug delivery may increase by using FUS beam in conjugation with nano--encapsulated drug carriers.The aim of this study is to investigate the effect of heat and ultrasound on the cellular uptake and therapeutic efficacy of an anticancer drug using Magnetic Resonance Imaging guided Focused Ultrasound (MRgFUS).
U2 - 10.1007/978-94-007-2555-3_13
DO - 10.1007/978-94-007-2555-3_13
M1 - Chapter
SN - 9789400725546
VL - 733
BT - Nano-biotechnology for biomedical and diagnostic research
T2 - Nano-biotechnology for biomedical and diagnostic research
A2 - Shafferman,Avigdor
ED - Shafferman,Avigdor
T3 - Advances in Experimental Medicine and Biology
T3 - en_GB
SP - 135
EP - 144
ER -