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Vitamin D supplementation did not prevent influenza-like illness as diagnosed retrospectively by questionnaires in subjects participating in randomized clinical trials

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Vitamin D supplementation did not prevent influenza-like illness as diagnosed retrospectively by questionnaires in subjects participating in randomized clinical trials. / Jorde, Rolf; Witham, Miles; Janssens, Wim; Rolighed, Lars; Borchhardt, Kyra; de Boer, Ian H.; Grimnes, Guri; Hutchinson, Moira S.

In: Scandinavian Journal of Infectious Diseases, Vol. 44, No. 2, 02.2012, p. 126-132.

Research output: Contribution to journalArticle

Harvard

Jorde, R, Witham, M, Janssens, W, Rolighed, L, Borchhardt, K, de Boer, IH, Grimnes, G & Hutchinson, MS 2012, 'Vitamin D supplementation did not prevent influenza-like illness as diagnosed retrospectively by questionnaires in subjects participating in randomized clinical trials' Scandinavian Journal of Infectious Diseases, vol 44, no. 2, pp. 126-132., 10.3109/00365548.2011.621446

APA

Jorde, R., Witham, M., Janssens, W., Rolighed, L., Borchhardt, K., de Boer, I. H., ... Hutchinson, M. S. (2012). Vitamin D supplementation did not prevent influenza-like illness as diagnosed retrospectively by questionnaires in subjects participating in randomized clinical trials. Scandinavian Journal of Infectious Diseases, 44(2), 126-132. 10.3109/00365548.2011.621446

Vancouver

Jorde R, Witham M, Janssens W, Rolighed L, Borchhardt K, de Boer IH et al. Vitamin D supplementation did not prevent influenza-like illness as diagnosed retrospectively by questionnaires in subjects participating in randomized clinical trials. Scandinavian Journal of Infectious Diseases. 2012 Feb;44(2):126-132. Available from: 10.3109/00365548.2011.621446

Author

Jorde, Rolf; Witham, Miles; Janssens, Wim; Rolighed, Lars; Borchhardt, Kyra; de Boer, Ian H.; Grimnes, Guri; Hutchinson, Moira S. / Vitamin D supplementation did not prevent influenza-like illness as diagnosed retrospectively by questionnaires in subjects participating in randomized clinical trials.

In: Scandinavian Journal of Infectious Diseases, Vol. 44, No. 2, 02.2012, p. 126-132.

Research output: Contribution to journalArticle

Bibtex - Download

@article{0a69d156b2f04ced9c1762e6d6566439,
title = "Vitamin D supplementation did not prevent influenza-like illness as diagnosed retrospectively by questionnaires in subjects participating in randomized clinical trials",
keywords = "H1N1, influenza, randomized clinical trial, vitamin D, RESPIRATORY-TRACT INFECTION, YOUNG FINNISH MEN, 25-HYDROXYVITAMIN-D, ASSOCIATION, RISK",
author = "Rolf Jorde and Miles Witham and Wim Janssens and Lars Rolighed and Kyra Borchhardt and {de Boer}, {Ian H.} and Guri Grimnes and Hutchinson, {Moira S.}",
year = "2012",
doi = "10.3109/00365548.2011.621446",
volume = "44",
number = "2",
pages = "126--132",
journal = "Scandinavian Journal of Infectious Diseases",
issn = "0036-5548",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Vitamin D supplementation did not prevent influenza-like illness as diagnosed retrospectively by questionnaires in subjects participating in randomized clinical trials

A1 - Jorde,Rolf

A1 - Witham,Miles

A1 - Janssens,Wim

A1 - Rolighed,Lars

A1 - Borchhardt,Kyra

A1 - de Boer,Ian H.

A1 - Grimnes,Guri

A1 - Hutchinson,Moira S.

AU - Jorde,Rolf

AU - Witham,Miles

AU - Janssens,Wim

AU - Rolighed,Lars

AU - Borchhardt,Kyra

AU - de Boer,Ian H.

AU - Grimnes,Guri

AU - Hutchinson,Moira S.

PY - 2012/2

Y1 - 2012/2

N2 - <p>Background: Vitamin D deficiency has been associated with a number of diseases, including influenza. Whether or not this reflects a causal relationship is unknown. We therefore wanted to examine if supplementation with vitamin D would affect the incidence and severity of influenza-like disease. Methods: Questionnaires on influenza were sent to subjects participating in ongoing placebo-controlled intervention studies with vitamin D supplementation, up until the end of April 2010. Results: Five hundred and sixty-nine subjects from 10 different clinical trials were included in the study, of whom 289 were randomized to receive vitamin D (1111-6800 IU/day) and 280 to receive placebo. Influenza-like disease during the previous fall/winter was reported in 38 subjects in the vitamin D group and 42 in the placebo group (non-significant), of whom 25 and 26 subjects, respectively, fulfilled our clinical criteria for influenza. In these latter subjects, the duration of illness was significantly longer among those in the vitamin D group than among those in the placebo group (median 7 (range 2-60) days vs median 4 (range 2-18) days; p = 0.007). However, this difference was not statistically significant if all 38 (vitamin D) and 42 (placebo) subjects who reported symptoms were included. Conclusion: Our results do not support the hypothesis that high doses of vitamin D supplementation will have a pronounced effect on influenza-like disease in populations not targeted for high influenza risk.</p>

AB - <p>Background: Vitamin D deficiency has been associated with a number of diseases, including influenza. Whether or not this reflects a causal relationship is unknown. We therefore wanted to examine if supplementation with vitamin D would affect the incidence and severity of influenza-like disease. Methods: Questionnaires on influenza were sent to subjects participating in ongoing placebo-controlled intervention studies with vitamin D supplementation, up until the end of April 2010. Results: Five hundred and sixty-nine subjects from 10 different clinical trials were included in the study, of whom 289 were randomized to receive vitamin D (1111-6800 IU/day) and 280 to receive placebo. Influenza-like disease during the previous fall/winter was reported in 38 subjects in the vitamin D group and 42 in the placebo group (non-significant), of whom 25 and 26 subjects, respectively, fulfilled our clinical criteria for influenza. In these latter subjects, the duration of illness was significantly longer among those in the vitamin D group than among those in the placebo group (median 7 (range 2-60) days vs median 4 (range 2-18) days; p = 0.007). However, this difference was not statistically significant if all 38 (vitamin D) and 42 (placebo) subjects who reported symptoms were included. Conclusion: Our results do not support the hypothesis that high doses of vitamin D supplementation will have a pronounced effect on influenza-like disease in populations not targeted for high influenza risk.</p>

KW - H1N1

KW - influenza

KW - randomized clinical trial

KW - vitamin D

KW - RESPIRATORY-TRACT INFECTION

KW - YOUNG FINNISH MEN

KW - 25-HYDROXYVITAMIN-D

KW - ASSOCIATION

KW - RISK

U2 - 10.3109/00365548.2011.621446

DO - 10.3109/00365548.2011.621446

M1 - Article

JO - Scandinavian Journal of Infectious Diseases

JF - Scandinavian Journal of Infectious Diseases

SN - 0036-5548

IS - 2

VL - 44

SP - 126

EP - 132

ER -

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