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Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

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Authors

  • Philip Cohen
  • Marianna Tcherpakov

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Info

Original languageEnglish
Pages686-693
Number of pages8
JournalCell
Journal publication date24 Nov 2010
Journal number5
Volume143
DOIs
StatePublished

Abstract

Protein phosphorylation and protein ubiquitination regulate most aspects of cell life, and defects in these control mechanisms cause cancer and many other diseases. In the past decade, protein kinases have become one of the most important classes of drug targets for the pharmaceutical industry. In contrast, drug discovery programs that target components of the ubiquitin system have lagged behind. In this Perspective, we discuss the reasons for the delay in this pipeline, the drugs targeting the ubiquitin system that have been developed, and new approaches that may popularize this area of drug discovery in the future.

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