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Wnt5a inhibits the CpG oligodeoxynucleotide-triggered activation of human plasmacytoid dendritic cells

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Wnt5a inhibits the CpG oligodeoxynucleotide-triggered activation of human plasmacytoid dendritic cells. / Hack, K; Reilly, L; Proby, C; Fleming, C; Leigh, I; Foerster, J.

In: Clinical and Experimental Dermatology, 2012.

Research output: Contribution to journalArticle

Harvard

Hack, K, Reilly, L, Proby, C, Fleming, C, Leigh, I & Foerster, J 2012, 'Wnt5a inhibits the CpG oligodeoxynucleotide-triggered activation of human plasmacytoid dendritic cells' Clinical and Experimental Dermatology.

APA

Hack, K., Reilly, L., Proby, C., Fleming, C., Leigh, I., & Foerster, J. (2012). Wnt5a inhibits the CpG oligodeoxynucleotide-triggered activation of human plasmacytoid dendritic cells. Clinical and Experimental Dermatology, doi: 10.1111/j.1365-2230.2012.04362.x

Vancouver

Hack K, Reilly L, Proby C, Fleming C, Leigh I, Foerster J. Wnt5a inhibits the CpG oligodeoxynucleotide-triggered activation of human plasmacytoid dendritic cells. Clinical and Experimental Dermatology. 2012.

Author

Hack, K; Reilly, L; Proby, C; Fleming, C; Leigh, I; Foerster, J / Wnt5a inhibits the CpG oligodeoxynucleotide-triggered activation of human plasmacytoid dendritic cells.

In: Clinical and Experimental Dermatology, 2012.

Research output: Contribution to journalArticle

Bibtex - Download

@article{66cc49355c8140a7a37e0628dcfcdfb9,
title = "Wnt5a inhibits the CpG oligodeoxynucleotide-triggered activation of human plasmacytoid dendritic cells",
author = "K Hack and L Reilly and C Proby and C Fleming and I Leigh and J Foerster",
year = "2012",
journal = "Clinical and Experimental Dermatology",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Wnt5a inhibits the CpG oligodeoxynucleotide-triggered activation of human plasmacytoid dendritic cells

A1 - Hack,K

A1 - Reilly,L

A1 - Proby,C

A1 - Fleming,C

A1 - Leigh,I

A1 - Foerster,J

AU - Hack,K

AU - Reilly,L

AU - Proby,C

AU - Fleming,C

AU - Leigh,I

AU - Foerster,J

PY - 2012

Y1 - 2012

N2 - Plasmacytoid dendritic cells (pDCs) fulfil multiple roles in immunity, and can secrete large amounts of interferon (IFN)-a. However, the available evidence suggests that they may actually counteract efficient antitumour immunity. Thus in melanoma, pDCs are abundant, but they are anergic and deficient in IFN-a secretion. pDC anergy is thought to be caused by immunosuppressive factors secreted by melanoma cells. One factor strongly expressed by melanoma is Wnt5a, which is implicated in cancer tissue invasion. In this paper, we show that Wnt5a is able to block the upregulation of the activation markers CD80 and CD86 on naive human pDCs stimulated by CpG oligodeoxynucleotide, and CpG-triggered secretion of IFN-a by pDCs. Our results suggest that Wnt5a may not only initiate cancer invasion, but could also regulate activation of pDC. These data provide a clear rationale to investigate a role for Wnt5a in immune regulation.

AB - Plasmacytoid dendritic cells (pDCs) fulfil multiple roles in immunity, and can secrete large amounts of interferon (IFN)-a. However, the available evidence suggests that they may actually counteract efficient antitumour immunity. Thus in melanoma, pDCs are abundant, but they are anergic and deficient in IFN-a secretion. pDC anergy is thought to be caused by immunosuppressive factors secreted by melanoma cells. One factor strongly expressed by melanoma is Wnt5a, which is implicated in cancer tissue invasion. In this paper, we show that Wnt5a is able to block the upregulation of the activation markers CD80 and CD86 on naive human pDCs stimulated by CpG oligodeoxynucleotide, and CpG-triggered secretion of IFN-a by pDCs. Our results suggest that Wnt5a may not only initiate cancer invasion, but could also regulate activation of pDC. These data provide a clear rationale to investigate a role for Wnt5a in immune regulation.

U2 - 10.1111/j.1365-2230.2012.04362.x

DO - 10.1111/j.1365-2230.2012.04362.x

M1 - Article

JO - Clinical and Experimental Dermatology

JF - Clinical and Experimental Dermatology

ER -

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