Biological Chemistry and Drug Discovery

Optimization of a “Bump-and-Hole” Approach to Allele-Selective BET Bromodomain Inhibition

Runcie, A., Zengerle, M., Chan, K. H., Testa, A., Van Beurden, L., Baud, M., Epemolu, R., Ellis, L., Read, K., Coulthard, V., Brien, A. & Ciulli, A. 9 Mar 2018 In : Chemical Science. 2018, 9, p. 2387-2634 18 p., 2452

Research output: Contribution to journal › Article

Exhaustive Sampling of the Fragment Space Associated to a Molecule Leading to the Generation of Conserved Fragments

Heikamp, K., Zuccotto, F., Kiczun, M., Ray, P. & Gilbert, I. H. 12 Dec 2017 In : Chemical Biology & Drug Design. 91, 3, p. 655-667 13 p.

Research output: Contribution to journal › Article

Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana

Mwenechanya, R., Kovářová, J., Dickens, N. J., Manikhandan, M., Herzyk, P., Vincent, I. M., Weidt, S. K., Burgess, K. E., Burchmore, R. J. S., Pountain, A. W., Smith, T. K., Creek, D. J., Kim, D. H., Lepesheva, G. I. & Barrett, M. P. 16 Jun 2017 In : PLoS Neglected Tropical Diseases. 11, 6, p. 1-21 21 p., e0005649

Research output: Contribution to journal › Article

Erythematous nodes, urticarial rash and arthralgias in a large pedigree with NLRC4-related autoinflammatory disease, expansion of the phenotype

Volker-Touw, C. M. L., de Koning, H. D., Giltay, J., de Kovel, C., van Kempen, T. S., Oberndorff, K., Boes, M., van Steensel, M. A. M., van Well, G. T. J., Blokx, W. A. M., Schalkwijk, J., Simon, A., Frenkel, J. & van Gijn, M. E. Jan 2017 In : British Journal of Dermatology. 176, 1, p. 244-248 5 p.

Research output: Contribution to journal › Letter

Mutations in POGLUT1 in Galli-Galli/Dowling Degos-disease

Wilson, N. J., Cole, C., Kroboth, K., Hunter, W. N., Mann, J. A., Irwin McLean, W. H., Kernland Lang, K., Beltraminelli, H., Sabroe, R. A., Tiffin, N., Sobey, G. J., Borradori, L., Simpson, E. & Smith, F. J. D. Jan 2017 In : British Journal of Dermatology. 176, 1, p. 270-274 5 p.

Research output: Contribution to journal › Letter

Isolated recessive nail dysplasia caused by FZD6 mutations: report of three families and review of the literature

Kasparis, C., Reid, D., Wilson, N. J., Okur, V., Cole, C., Hansen, C. D., Bosse, K., Betz, R. C., Khan, M. & Smith, F. J. D. Dec 2016 In : Clinical and Experimental Dermatology. 41, 8, p. 884-889 6 p.

Research output: Contribution to journal › Article

MSAViewer: interactive JavaScript visualization of multiple sequence alignments

Yachdav, G., Wilzbach, S., Rauscher, B., Sheridan, R., Sillitoe, I., Procter, J., Lewis, S. E., Rost, B. & Goldberg, T. 15 Nov 2016 In : Bioinformatics. 32, 22, p. 3501-3503 3 p.

Research output: Contribution to journal › Article

Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases

Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. & Dinkova-Kostova, A. T. 15 Sep 2016 In : Molecular and Cellular Biology. 36, 18, p. 2403-2417 15 p.

Research output: Contribution to journal › Article

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

Baragaña, B. , Hallyburton, I. , Lee, M. C. S. , Norcross, N. R. , Grimaldi, R. , Otto, T. D. , Proto, W. R. , Blagborough, A. M. , Meister, S. , Wirjanata, G. , Ruecker, A. , Upton, L. M. , Abraham, T. S. , Almeida, M. J. , Pradhan, A. , Porzelle, A. , Santos Martinez, M. , Bolscher, J. M. , Woodland, A. , Luksch, T. & 44 others Norval, S., Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Jiménez-Díaz, M. B., Sanz, L. M., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Javier Gamo, F., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S., Marfurt, J., Price, R. N., Sinden, R. E., Winzeler, E. A., Charman, S. A., Bebrevska, L., Gray, D. W., Campbell, S., Fairlamb, A. H., Willis, P. A., Rayner, J. C., Fidock, D. A., Read, K. D. & Gilbert, I. H. 25 May 2016 In : Nature. 537, 7618, p. 122 1 p.

Research output: Contribution to journal › Article

Phosphoinositides, kinases and adaptors coordinating endocytosis in Trypanosoma brucei

Manna, P. T. & Field, M. C. 12 Apr 2016 In : Communicative & Integrative Biology. 8, 6, p. e1082691-1-e1082691-4 4 p., e1082691

Research output: Contribution to journal › Article