Biological Chemistry and Drug Discovery

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.

De Rycker, M., Hallyburton, I., Thomas, J., Campbell, L., Wyllie, S., Joshi, D., Cameron, S., Gilbert, I. H., Wyatt, P. G., Frearson, J. A., Fairlamb, A. H. & Gray, D. W. 2013 In : Antimicrobial Agents and Chemotherapy.

Research output: Contribution to journal › Article

Electromechanical Behaviour of Nafion-based Soft Actuators

Naji, L., Chudek, J. A., Abel, E. W. & Baker, R. T. 2013 In : Journal of Physical Chemistry B. 1, 19, p. 2502-2514, 13 p.

Research output: Contribution to journal › Article

Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry

Hahne, H., Sobotzki, N., Nyberg, T., Helm, D., Borodkin, V. S., van Aalten, D. M. F., Agnew, B. & Kuster, B. 2013 In : Journal of Proteome Research. 12, 2, p. 927-936, 10 p.

Research output: Contribution to journal › Article

Regulation of the cardiac Na(+) pump by palmitoylation of its catalytic and regulatory subunits

Howie, J., Tulloch, L. B., Shattock, M. J. & Fuller, W. 2013 In : Biochemical Society Transactions. 41, 1, p. 95-100, 6 p.

Research output: Contribution to journal › Article

Structure of Pseudomonas aeruginosa inosine 5-monophosphate dehydrogenase

Rao, V. A., Shepherd, S. M., Owen, R. & Hunter, W. N. 2013 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 3, p. 243-247, 5 p.

Research output: Contribution to journal › Article

The plasticity of a structural motif in RNA: Structural polymorphism of a kink turn as a function of its environment

Daldrop, P. & Lilley, D. M. J. 2013 In : RNA: a Publication of the RNA Society. 19, 3, p. 357-364, 8 p.

Research output: Contribution to journal › Article

Automated design of ligands to polypharmacological profiles

Gilbert, I. H. & 20 others Besnard, J., Ruda, G. F., Setola, V., Abecassis, K., Rodriguiz, R. M., Huang, X-P., Norval, S., Sassano, M. F., Shin, A. I., Webster, L. A., Simeons, F. R. C., Stojanovski, L., Prat, A., Seidah, N. G., Constam, D. B., Bickerton, G. R., Read, K. D., Wetsel, W. C., Roth, B. L. & Hopkins, A. L. 13-Dec-2012 In : Nature. 492, 7428, p. 215-+, 8 p.

Research output: Contribution to journal › Article

Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P-3-dependent mechanisms leading to resistance to PDK1 inhibitors

Najafov, A., Shpiro, N. & Alessi, D. R. Dec-2012 In : Biochemical Journal. 448, 2, p. 285-295, 11 p.

Research output: Contribution to journal › Article

A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes

De Rycker, M., O'Neill, S., Joshi, D., Campbell, L., Gray, D. W. & Fairlamb, A. H. 29-Nov-2012 In : PLoS Neglected Tropical Diseases. 6, 11, p. e1932

Research output: Contribution to journal › Article

Structural plasticity of histones H3–H4 facilitates their allosteric exchange between RbAp48 and ASF1

Zhang, W., Yyl, M., Ward, R., Sobott, F., Maman, J., Murthy, A., Watson, A., Fedorov, O., Bowman, A., Owen-Hughes, T., El Mkami, H., Murzina, N., Norman, D. G. & Laue, E. 25-Nov-2012 In : Nature Structural & Molecular Biology. 20, 1, p. 29-35

Research output: Contribution to journal › Article