Biological Chemistry and Drug Discovery

Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α

Buckley, D. L., Gustafson, J. L., Van-Molle, I., Roth, A. G., Tae, H. S., Gareiss, P. C., Jorgensen, W. L., Ciulli, A. & Crews, C. M. 12-Nov-2012 In : Angewandte Chemie International Edition. 51, 46, p. 11463-11467, 5 p.

Research output: Contribution to journal › Article

Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei

Urbaniak, M. D., Mathieson, T., Bantscheff, M., Eberhard, D., Grimaldi, R., Miranda-Saavedra, D., Wyatt, P., Ferguson, M. A. J., Frearson, J. & Drewes, G. Nov-2012 In : ACS Chemical Biology. 7, 11, p. 1858-1865, 8 p.

Research output: Contribution to journal › Article

Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma

Pohler, E. , Mamai, O. , Hirst, J. , Zamiri, M. , Horn, H. , Nomura, T. , Irvine, A. D. , Moran, B. , Wilson, N. J. , Smith, F. J. D. , Goh, C. S. M. , Sandilands, A. , Cole, C. , Barton, G. J. , Evans, A. T. , Shimizu, H. , Akiyama, M. , Suehiro, M. , Konohana, I. , Shboul, M. & 12 others Teissier, S., Boussofara, L., Denguezli, M., Saad, A., Gribaa, M., Dopping-Hepenstal, P. J., McGrath, J. A., Brown, S. J., Goudie, D. R., Reversade, B., Munro, C. S. & McLean, W. H. I. Nov-2012 In : Nature Genetics. 44, 11, p. 1272-1276, 5 p.

Research output: Contribution to journal › Article

New secreted toxins and immunity proteins encoded within the type VI secretion system gene cluster of Serratia marcescens

English, G., Trunk, K., Rao, V. A., Srikannathasan, V., Hunter, W. N. & Coulthurst, S. J. Nov-2012 In : Molecular Microbiology. 86, 4, p. 921-936, 16 p.

Research output: Contribution to journal › Article

Dissecting fragment-based lead discovery at the von hippel-lindau protein: Hypoxia inducible factor 1α protein-protein interface

Van Molle, I., Thomann, A., Buckley, D. L., So, E. C., Lang, S., Crews, C. M. & Ciulli, A. 26-Oct-2012 In : Chemistry & Biology. 19, 10, p. 1300-1312, 13 p.

Research output: Contribution to journal › Article

Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

Jones, D. C., Alphey, M. S., Wyllie, S. & Fairlamb, A. H. Oct-2012 In : Molecular Microbiology. 86, 1, p. 51-64, 14 p.

Research output: Contribution to journal › Article

Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121

Hudson, S. A., McLean, K. J., Surade, S., Yang, Y-Q., Leys, D., Ciulli, A., Munro, A. W. & Abell, C. 10-Sep-2012 In : Angewandte Chemie International Edition. 51, 37, p. 9311-9316, 6 p.

Research output: Contribution to journal › Article

Transcriptome analysis of atopic skin demonstrates the importance of extracellular mechanisms in the filaggrin-related barrier defect

Brown, S., Cole, C., McLean, I., Barton, G. & Irvine, A. Sep-2012 In : Journal of Investigative Dermatology. 132, p. S94-S94, 1 p.

Research output: Contribution to journal › Meeting abstract

Essential Role for IKK beta in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

Pauls, E., Shpiro, N., Peggie, M., Young, E. R., Sorcek, R. J., Tan, L., Choi, H. G. & Cohen, P. 1-Jun-2012 In : Journal of Biological Chemistry. 287, 23, p. 19216-19228, 13 p.

Research output: Contribution to journal › Article

Pathways analysis in kidney cancer using proteomics approach

Zakikhani, M., Atrih, A., Lamont, S. R., Goodman, C., Fleming, I. N. & Nabi, G. Jun-2012 In : BJU International. 109, p. 24-24, 1 p.

Research output: Contribution to journal › Special issue