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Biological Chemistry and Drug Discovery

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  1. Drug discovery for the treatment of leishmaniasis, African sleeping sickness and Chagas disease

    Avery, V., Buckner, F., Baell, J., Fairlamb, A., Michels, P. A. & Tarleton, R. Oct 2013 In : Future Medicinal Chemistry. 5, 15, p. 1709-1718 10 p.

    Research output: Contribution to journalArticle

  2. The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

    Patterson, S., Wyllie, S., Stojanovski, L., Perry, M. R., Simeons, F. R. C., Norval, S., Osuna-Cabello, M., De Rycker, M., Read, K. D. & Fairlamb, A. H. Oct 2013 In : Antimicrobial Agents and Chemotherapy. 57, 10, p. 4699-4706 8 p.

    Research output: Contribution to journalArticle

  3. A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei

    Urbaniak, M. D., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Navratilova, I. H., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J. 20 Sep 2013 In : ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.

    Research output: Contribution to journalArticle

  4. Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase

    Hampton, S. E., Schipani, A., Bosch-Navarrete, C., Recio, E., Kaiser, M., Kahnberg, P., González-Pacanowska, D., Johansson, N. G. & Gilbert, I. H. 15 Sep 2013 In : Bioorganic & Medicinal Chemistry. 21, 18, p. 5876-5885 10 p.

    Research output: Contribution to journalArticle

  5. Yeast Mnn9 is both a priming glycosyltransferase and an allosteric activator of mannan biosynthesis

    Striebeck, A., Robinson, D. A., Schüttelkopf, A. W. & van Aalten, D. M. F. Sep 2013 In : Open Biology. 3, 9, 130022

    Research output: Contribution to journalArticle

  6. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery

    Silvestre, H. L., Blundell, T. L., Abell, C. & Ciulli, A. 6 Aug 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 32, p. 12984-12989 6 p.

    Research output: Contribution to journalArticle

  7. Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target

    Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Urbaniak, M. D., Ibrahim, A. F. M., Ferguson, M. A. J., Jin, C. & van Aalten, D. M. F. Aug 2013 In : Molecular Microbiology. 89, 3, p. 479-493 15 p.

    Research output: Contribution to journalArticle

  8. Multimeric complexes among Ankyrin-Repeat and SOCS-box Protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 Ubiquitin Ligases

    Thomas, J. C., Matak-Vinkovic, D., Van Molle, I. & Ciulli, A. 25 Jul 2013 In : Biochemistry. 52, 31, p. 5236-5246 11 p.

    Research output: Contribution to journalArticle

  9. Structure of the SCAN domain of human paternally expressed gene 3 protein

    Rimsa, V., Eadsforth, T. C. & Hunter, W. N. 23 Jul 2013 In : PLoS ONE. 8, 7, e69538

    Research output: Contribution to journalArticle

  10. Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.

    De Rycker, M., Hallyburton, I., Thomas, J., Campbell, L., Wyllie, S., Joshi, D., Cameron, S., Gilbert, I. H., Wyatt, P. G., Frearson, J. A., Fairlamb, A. H. & Gray, D. W. Jul 2013 In : Antimicrobial Agents and Chemotherapy. 57, 7, p. 2913-2922 10 p.

    Research output: Contribution to journalArticle

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