Biological Chemistry and Drug Discovery

Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

Hjerpe, R., Thomas, Y., Chen, J., Zemla, A., Curran, S., Shpiro, N., Dick, L. R. & Kurz, T. 1-Feb-2012 In : Biochemical Journal. 441, p. 927-936, 10 p.

Research output: Contribution to journal › Article

The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis

Wyllie, S., Patterson, S., Stojanovski, L., Simeons, F. R. C., Norval, S., Kime, R., Read, K. D. & Fairlamb, A. H. 1-Feb-2012 In : Science Translational Medicine. 4, 119, p. -, 7 p., 119re1

Research output: Contribution to journal › Article

Biosensor-Based Approach to the Identification of Protein Kinase Ligands with Dual-Site Modes of Action

Navratilova, I., Macdonald, G., Robinson, C., Hughes, S., Mathias, J., Phillips, C. & Cook, A. Feb-2012 In : Journal of Biomolecular Screening. 17, 2, p. 183-193, 11 p.

Research output: Contribution to journal › Article

Quantifying the chemical beauty of drugs

Bickerton, G. R., Paolini, G. V., Besnard, J., Muresan, S. & Hopkins, A. L. Feb-2012 In : Nature Chemistry. 4, 2, p. 90-98, 9 p.

Research output: Contribution to journal › Article

The crystal structure of Leishmania major N-5,N-10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target

Eadsforth, T. C., Cameron, S. & Hunter, W. N. Feb-2012 In : Molecular and Biochemical Parasitology. 181, 2, p. 178-185, 8 p.

Research output: Contribution to journal › Article

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Brand, S., Cleghorn, L. A. T., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Read, K. D., Wyatt, P. G. & Gilbert, I. H. 12-Jan-2012 In : Journal of Medicinal Chemistry. 55, 1, p. 140-152, 13 p.

Research output: Contribution to journal › Article

The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces

Wong, E., Vaaje-Kolstad, G., Ghosh, A., Hurtado-Guerrero, R., Konarev, P. V., Ibrahim, A. F. M., Svergun, D. I., Eijsink, V. G. H., Chatterjee, N. S. & van Aalten, D. M. F. 12-Jan-2012 In : PLoS Pathogens. 8, 1, e1002373

Research output: Contribution to journal › Article

Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

Spinks, D., Torrie, L. S., Thompson, S., Harrison, J. R., Frearson, J. A., Read, K. D., Fairlamb, A. H., Wyatt, P. G. & Gilbert, I. H. 2-Jan-2012 In : ChemMedChem. 7, 1, p. 95-106, 12 p.

Research output: Contribution to journal › Article

A comparative study of the CYP450 inhibition potential of marketed drugs using two fluorescence based assay platforms routinely used in the pharmaceutical industry

Kajbaf, M., Longhi, R., Montanari, D., Vinco, F., Rigo, M., Fontano, S. & Read, K. D. 2012 In : Drug Metabolism Letters. 5, 1, p. 30-39, 10 p.

Research output: Contribution to journal › Article

Allosteric Competitive Inhibitors of the Glucose-1-phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa

Alphey, M. S., Pirrie, L., Torrie, L. S., Boulkeroua, W. A., Gardiner, M., Sarkar, A., Maringer, M., Oehlmann, W., Brenk, R., Scherman, M. S., McNeil, M., Rejzek, M., Field, R. A., Singh, M., Gray, D., Westwood, N. J. & Naismith, J. H. 2012 In : ACS Chemical Biology.

Research output: Contribution to journal › Article