Discovery - University of Dundee - Online Publications

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Biological Chemistry and Drug Discovery

  1. Synergistic inhibition of ErbB signaling by combined treatment with seliciclib and ErbB-targeting agents

    Fleming, I. N., Hogben, M., Frame, S., McClue, S. J. & Green, S. R. 1 Jul 2008 In : Clinical Cancer Research. 14, 13, p. 4326-35 10 p.

    Research output: Contribution to journalArticle

  2. Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes

    Sienkiewicz, N., Jaroslawski, S., Wyllie, S. & Fairlamb, A. H. Jul 2008 In : Molecular Microbiology. 69, 2, p. 520-533 14 p.

    Research output: Contribution to journalArticle

  3. Evaluation of direct transport pathways of glycine receptor antagonists and an angiotensin antagonist from the nasal cavity to the central nervous system in the rat model

    Charlton, S. T., Whetstone, J., Fayinka, S. T., Read, K. D., Illum, L. & Davis, S. S. Jul 2008 In : Pharmaceutical Research. 25, 7, p. 1531-1543 13 p.

    Research output: Contribution to journalArticle

  4. SCANPS: a web server for iterative protein sequence database searching by dynamic programing, with display in a hierarchical SCOP browser

    Walsh, T. P., Webber, C., Searle, S., Sturrock, S. S. & Barton, G. J. Jul 2008 In : Nucleic Acids Research. 36, p. W25-W29 5 p.

    Research output: Contribution to journalArticle

  5. TarO: a target optimisation system for structural biology

    Overton, I. M., van Niekerk, C. A. J., Carter, L. G., Dawson, A., Martin, D. M. A., Cameron, S., McMahon, S. A., White, M. F., Hunter, W. N., Naismith, J. H. & Barton, G. J. Jul 2008 In : Nucleic Acids Research. 36, p. W190-W196 7 p.

    Research output: Contribution to journalArticle

  6. The Jpred 3 secondary structure prediction server

    Cole, C., Barber, J. D. & Barton, G. J. Jul 2008 In : Nucleic Acids Research. 36, S2, p. W197-W201 5 p.

    Research output: Contribution to journalArticle

  7. Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities

    Fyfe, P. K., Oza, S. L., Fairlamb, A. H. & Hunter, W. N. 20 Jun 2008 In : Journal of Biological Chemistry. 283, 25, p. 17672-17680 9 p.

    Research output: Contribution to journalArticle

  8. The synthesis of UDP-N-acetylglucosamine is essential for bloodstream form Trypanosoma brucei in vitro and in vivo and UDP-N-acetylglucosamine starvation reveals a hierarchy in parasite protein glycosylation

    Stokes, M. J., Guther, M. L. S., Turnock, D. C., Prescott, A. R., Martin, K. L., Alphey, M. S. & Ferguson, M. A. J. 6 Jun 2008 In : Journal of Biological Chemistry. 283, 23, p. 16147-16161 15 p.

    Research output: Contribution to journalArticle

  9. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

    Huang, X., Wullschleger, S., Shpiro, N., McGuire, V. A., Sakamoto, K., Woods, Y. L., McBurnie, W., Fleming, S. & Alessi, D. R. 1 Jun 2008 In : Biochemical Journal. 412, p. 211-221 11 p.

    Research output: Contribution to journalArticle

  10. Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-D-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery

    Sgraja, T., Alphey, M. S., Ghilagaber, S., Marquez, R., Robertson, M. N., Hemmings, J. L., Lauw, S., Rohdich, F., Bacher, A., Eisenreich, W., Illarionova, V. & Hunter, W. N. Jun 2008 In : FEBS Journal. 275, 11, p. 2779-2794 16 p.

    Research output: Contribution to journalArticle

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