Biological Chemistry and Drug Discovery

A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major

Vickers, T. J., Greig, N. & Fairlamb, A. H. 2004 In : Proceedings of the National Academy of Sciences. 101, 36, p. 13186-13191, 6 p.

Research output: Contribution to journal › Article

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

Scott, J. W., Hawley, S. A., Green, K. A., Anis, M., Stewart, G., Scullion, G. A., Norman, D. G. & Hardie, D. G. 2004 In : Journal of Clinical Investigation. 113, 2, p. 274-284, 11 p.

Research output: Contribution to journal › Article

Crystal structure of MO25 in complex with the C terminus of the pseudo kinase STE20-related adaptor

Milburn, C. C., Boudeau, J., Deak, M., Alessi, D. R. & van Aalten, D. M. F. 2004 In : Nature Structural & Molecular Biology. 11, 2, p. 193-200, 8 p.

Research output: Contribution to journal › Article

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1

Hopkins, A. L., Ren, J., Milton, J., Hazen, R. J., Chan, J. H., Stuart, D. I. & Stammers, D. K. 2004 In : Journal of Medicinal Chemistry. 47, 24, p. 5912-5922, 11 p.

Research output: Contribution to journal › Article

Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani

Wyllie, S., Cunningham, M. L. & Fairlamb, A. H. 2004 In : Journal of Biological Chemistry. 279, 38, p. 39925-39932, 8 p.

Research output: Contribution to journal › Article

Non spiral and spiral (helical) flow patterns in stenoses. In vitro observations using spin and gradient echo magnetic resonance imaging (MRI) and computational fluid dynamic modeling

Stonebridge, P. A., Buckley, C., Thompson, A., Dick, J., Hunter, G., Chudek, J. A., Houston, J. G. & Belch, J. J. F. 2004 In : International Angiology. 23, 3, p. 276-283, 8 p.

Research output: Contribution to journal › Article

Phosphatidylinositol 3-kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients

James, M. J. & Zomerdijk, J. C. B. M. 2004 In : Journal of Biological Chemistry. 279, 10, p. 8911-8918, 8 p.

Research output: Contribution to journal › Article

Sensing of remote oxyanion binding at the DNA binding domain of the molybdate-dependent transcriptional regulator, ModE

Boxer, D. H., Zhang, H., Gourley, D. G., Hunter, W. N., Kelly, S. M. & Price, N. C. 2004 In : Organic and Biomolecular Chemistry. 2, 19, p. 2829-2837, 9 p.

Research output: Contribution to journal › Article

Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo

Thompson, A. M. & 23 others Spruce, B. A., Campbell, L. A., McTavish, N., Cooper, M. A., Appleyard, M. V. L., O'Neill, M., Howie, J., Samson, J., Watt, S., Murray, K., McLean, D., Leslie, N. R., Safrany, S. T., Ferguson, M. J., Peters, J. A., Prescott, A. R., Box, G., Hayes, A., Nutley, B., Raynaud, F., Downes, C. P., Lambert, J. J. & Eccles, S. 2004 In : Cancer Research. 64, 1, p. 4875-4886, 12 p.

Research output: Contribution to journal › Article

Structure-based exploration of cyclic dipeptide chitinase inhibitors

Houston, D. R., Synstad, B., Eijsink, V. G. H., Stark, M. J. R., Eggleston, I. M. & van Aalten, D. M. F. 2004 In : Journal of Medicinal Chemistry. 47, 23, p. 5713-20, 8 p.

Research output: Contribution to journal › Article