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Biological Chemistry and Drug Discovery

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  1. Toward an improved prediction of human in vivo brain penetration

    Summerfield, S. G., Lucas, A. J., Porter, R. A., Jeffrey, P., Gunn, R. N., Read, K. R., Stevens, A. J., Metcalf, A. C., Osuna-Cabello, M. C., Kilford, P. J., Passchier, J. & Ruffo, A. D. 2008 In : Xenobiotica. 38, 12, p. 1518-1535 18 p.

    Research output: Contribution to journalArticle

  2. The selectivity of protein kinase inhibitors: a further update

    Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., Mclauchlan, H., Klevernic, I., Arthur, J. S. C., Alessi, D. R. & Cohen, P. 15 Dec 2007 In : Biochemical Journal. 408, p. 297-315 19 p.

    Research output: Contribution to journalArticle

  3. Efficient synthesis of 1,3,7-substituted xanthines by a safety-catch protection strategy

    Allwood, M., Cannan, B., van Aalten, D. M. F. & Eggleston, I. M. 10 Dec 2007 In : Tetrahedron. 63, 50, p. 12294-12302 9 p.

    Research output: Contribution to journalArticle

  4. Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development

    Eoh, H., Brown, A. C., Buetow, L., Hunter, W. N., Parish, T., Kaur, D., Brennan, P. J. & Crick, D. C. Dec 2007 In : Journal of Bacteriology. 189, 24, p. 8922-8927 6 p.

    Research output: Contribution to journalArticle

  5. Micro-magnetic resonance imaging of avian embryos

    Li, X., Liu, J., Davey, M., Duce, S., Jaberi, N., Liu, G., Davidson, G., Tenent, S., Mahood, R., Brown, P., Cunningham, C., Bain, A., Beattie, K., McDonald, L., Schmidt, K., Towers, M., Tickle, C. & Chudek, S. Dec 2007 In : Journal of Anatomy. 211, 6, p. 798-809 12 p.

    Research output: Contribution to journalArticle

  6. Target assessment for antiparasitic drug discovery

    Frearson, J. A., Wyatt, P. G., Gilbert, I. H. & Fairlamb, A. H. Dec 2007 In : Trends in Parasitology. 23, 12, p. 589-595 7 p.

    Research output: Contribution to journalScientific review

  7. A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major

    König, J. & Fairlamb, A. H. Nov 2007 In : FEBS Journal. 274, 21, p. 5643-5658 16 p.

    Research output: Contribution to journalArticle

  8. Distance determination in heterogeneous DNA model systems by pulsed EPR

    Ward, R., Keeble, D. J., El-Mkami, H. & Norman, D. G. Nov 2007 In : ChemBioChem. 8, 16, p. 1957-1964 8 p.

    Research output: Contribution to journalArticle

  9. Picking pockets to fuel antimicrobial drug discovery

    Hunter, W. N. Nov 2007 In : Biochemical Society Transactions. 35, p. 980-984 5 p.

    Research output: Contribution to journalArticle

  10. Quinuclidine derivatives as potential antiparasitics

    Cammerer, S. B., Jimenez, C., Jones, S., Gros, L., Lorente, S. O., Rodrigues, C., Rodrigues, J. C. F., Caldera, A., Perez, L. M. R., da Souza, W., Kaiser, M., Brun, R., Urbina, J. A., Pacanowska, D. G. & Gilbert, I. H. Nov 2007 In : Antimicrobial Agents and Chemotherapy. 51, 11, p. 4049-4061 13 p.

    Research output: Contribution to journalArticle

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