Biological Chemistry and Drug Discovery

Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

Spinks, D., Torrie, L. S., Thompson, S., Harrison, J. R., Frearson, J. A., Read, K. D., Fairlamb, A. H., Wyatt, P. G. & Gilbert, I. H. 2-Jan-2012 In : ChemMedChem. 7, 1, p. 95-106, 12 p.

Research output: Contribution to journal › Article

A comparative study of the CYP450 inhibition potential of marketed drugs using two fluorescence based assay platforms routinely used in the pharmaceutical industry

Kajbaf, M., Longhi, R., Montanari, D., Vinco, F., Rigo, M., Fontano, S. & Read, K. D. 2012 In : Drug Metabolism Letters. 5, 1, p. 30-39, 10 p.

Research output: Contribution to journal › Article

Allosteric Competitive Inhibitors of the Glucose-1-phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa

Alphey, M. S., Pirrie, L., Torrie, L. S., Boulkeroua, W. A., Gardiner, M., Sarkar, A., Maringer, M., Oehlmann, W., Brenk, R., Scherman, M. S., McNeil, M., Rejzek, M., Field, R. A., Singh, M., Gray, D., Westwood, N. J. & Naismith, J. H. 2012 In : ACS Chemical Biology.

Research output: Contribution to journal › Article

Assessment of pseudomonas aeruginosa N-5,N-10-methylenetetrahydrofolate dehydrogenase - cyclohydrolase as a potential antibacterial drug target

Eadsforth, T. C., Gardiner, M., Maluf, F. V., McElroy, S., James, D., Frearson, J., Gray, D. & Hunter, W. N. 2012 In : PLoS ONE. 7, 4, p. -, 11 p., e35973

Research output: Contribution to journal › Article

Avirulence protein 3a (AVR3a) from the potato pathogen Phytophthora infestans forms homodimers through its predicted translocation region and does not specifically bind phospholipids

Wawra, S., Agacan, M., Boddey, J. A., Davidson, I., Gachon, C. M. M., Zanda, M., Grouffaud, S., Whisson, S. C., Birch, P. R. J., Porter, A. J. & Van West, P. 2012 In : Journal of Biological Chemistry. 287, 45, p. 38101-38109, 9 p.

Research output: Contribution to journal › Article

BioJava: an open-source framework for bioinformatics in 2012

Prlic, A., Yates, A., Bliven, S. E., Rose, P. W., Jacobsen, J., Troshin, P. V., Chapman, M., Gao, J., Koh, C. H., Foisy, S., Holland, R., Rimsa, G., Heuer, M. L., Brandstaetter-Mueller, H., Bourne, P. E. & Willis, S. 2012 In : Bioinformatics. 28, 20, p. 2693-2695, 3 p.

Research output: Contribution to journal › Article

Change or be changed: reflections of the workshop 'Future in Medicinal Chemistry'

Brenk, R. & Rauh, D. 2012 In : Bioorganic & Medicinal Chemistry. 20, 12, p. 3695-3697, 3 p.

Research output: Contribution to journal › Article

Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo

Wishart, T. M., Rooney, T. M., Lamont, D. J., Wright, A. K., Morton, A. J., Jackson, M., Freeman, M. R. & Gillingwater, T. H. 2012 In : PLoS Genetics. 8, 8

Research output: Contribution to journal › Article

Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages

Urbaniak, M. D., Guther, M. L. S. & Ferguson, M. A. J. 2012 In : PLoS ONE. 7, 5, p. -, 8 p., e36619

Research output: Contribution to journal › Article

Direct sequencing of Arabidopsis thaliana RNA reveals patterns of cleavage and polyadenylation

Sherstnev, A., Duc, C., Cole, C., Zacharaki, V., Hornyik, C., Ozsolak, F., Milos, P. M., Barton, G. J. & Simpson, G. G. 2012 In : Nature Structural & Molecular Biology.

Research output: Contribution to journal › Article