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  1. A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes

    Galvin, B. D., Li, Z., Villemaine, E., Poole, C. B., Chapman, M. S., Pollastri, M. P., Wyatt, P. G. & Carlow, C. K. S. Sep 2014 In : PLoS Neglected Tropical Diseases. 8, 9, 13 p.e3145

    Research output: Contribution to journalArticle

  2. ATP7B activity is stimulated by PKCɛ in porcine liver

    Cardoso, L. H. D., Britto Borges, T., Vieyra, A. & Lowe, J. Sep 2014 In : International Journal of Biochemistry & Cell Biology. 54, p. 60-67 8 p.

    Research output: Contribution to journalArticle

  3. Crystal structure and mechanistic investigation of the twister ribozyme

    Liu, Y., Wilson, T. J., McPhee, S. A. & Lilley, D. M. J. Sep 2014 In : Nature Chemical Biology. 10, 9, p. 739-744 6 p.

    Research output: Contribution to journalArticle

  4. Quantification of biliary excretion and sinusoidal excretion of 5(6)-carboxy-2',7'-dichlorofluorescein (CDF) in cultured hepatocytes isolated from Sprague Dawley, Wistar and Mrp2-deficient Wistar (TR-) rats

    Ellis, L. C. J., Grant, M. H., Hawksworth, G. M. & Weaver, R. J. Sep 2014 In : Toxicology in Vitro. 28, 6, p. 1165-1175 11 p.

    Research output: Contribution to journalArticle

  5. Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1

    Khalaf, A. I., Huggan, J. K., Suckling, C. J., Gibson, C. L., Stewart, K., Giordani, F., Barrett, M. P., Wong, P. E., Barrack, K. L. & Hunter, W. N. 14 Aug 2014 In : Journal of Medicinal Chemistry. 57, 15, p. 6479-6494 16 p.

    Research output: Contribution to journalArticle

  6. Molecular cloning and functional characterization of components of the capsule biosynthesis complex of Neisseria meningitidis serogroup A: toward in vitro vaccine production

    Fiebig, T., Freiberger, F., Pinto, V., Romano, M. R., Black, A., Litschko, C., Bethe, A., Yashunsky, D., Adamo, R., Nikolaev, A., Berti, F. & Gerardy-Schahn, R. 11 Jul 2014 In : Journal of Biological Chemistry. 289, 28, p. 19395-19407 13 p.

    Research output: Contribution to journalArticle

  7. C-reactive protein is essential for innate resistance to pneumococcal infection

    Simons, J. P., Loeffler, J. M., Al-Shawi, R., Ellmerich, S., Hutchinson, W. L., Tennent, G. A., Petrie, A., Raynes, J. G., de Souza, J. B., Lawrence, R. A., Read, K. D. & Pepys, M. B. Jul 2014 In : Immunology. 142, 3, p. 414-420 7 p.

    Research output: Contribution to journalArticle

  8. Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

    Cole, C., Kroboth, K., Schurch, N. J., Sandilands, A., Sherstnev, A., O'Regan, G. M., Watson, R. M., McLean, W. H. I., Barton, G. J., Irvine, A. D. & Brown, S. J. Jul 2014 In : Journal of Allergy and Clinical Immunology. 134, 1, p. 82-91 10 p.

    Research output: Contribution to journalArticle

  9. Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human african trypanosomiasis

    Sullivan, L., Fleming, J., Sastry, L., Mehlert, A., Wall, S. J. & Ferguson, M. A. J. Jul 2014 In : PLoS Neglected Tropical Diseases. 8, 7, p. e2976

    Research output: Contribution to journalArticle

  10. Validity of ligand efficiency metrics

    Murray, C. W., Erlanson, D. A., Hopkins, A. L., Keserü, G. M., Leeson, P. D., Rees, D. C., Reynolds, C. H. & Richmond, N. J. 12 Jun 2014 In : ACS Medicinal Chemistry Letters. 5, 6, p. 616-618 3 p.

    Research output: Contribution to journalArticle

  11. Glycogen Synthase Kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells

    Sarshad, A. A., Corcoran, M., Al-Muzzaini, B., Borgonovo-Brandter, L., Von Euler, A., Lamont, D., Visa, N. & Percipalle, P. 5 Jun 2014 In : PLoS Genetics. 10, 6, 17 p.e1004390

    Research output: Contribution to journalArticle

  12. TbGT8 is a bifunctional glycosyltransferase that elaborates N-linked glycans on a protein phosphatase AcP115 and a GPI-anchor modifying glycan in Trypanosoma brucei

    Nakanishi, M., Karasudani, M., Shiraishi, T., Hashida, K., Hino, M., Ferguson, M. A. J. & Nomoto, H. Jun 2014 In : Parasitology International. 63, 3, p. 513-518 6 p.

    Research output: Contribution to journalArticle

  13. Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei

    Alsford, S., Currier, R. B., Guerra-Assunção, J. A., Clark, T. G. & Horn, D. 15 May 2014 In : PLoS Pathogens. 10, 5, 12 p.e1004130

    Research output: Contribution to journalArticle

  14. Nuclear pore complex evolution: a trypanosome Mlp analogue functions in chromosomal segregation but lacks transcriptional barrier activity

    Holden, J. M., Koreny, L., Obado, S., Ratushny, A. V., Chen, W-M., Chiang, J-H., Kelly, S., Chait, B. T., Aitchison, J. D., Rout, M. P. & Field, M. C. 1 May 2014 In : Molecular Biology of the Cell. 25, 9, p. 1421-1436 16 p.

    Research output: Contribution to journalArticle

  15. Life and times: synthesis, trafficking, and evolution of VSG

    Manna, P. T., Boehm, C., Leung, K. F., Natesan, S. K. & Field, M. C. May 2014 In : Trends in Parasitology. 30, 5, p. 251-258 8 p.

    Research output: Contribution to journalArticle

  16. The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma brucei

    Lilley, A. C., Major, L., Young, S., Stark, M. J. R. & Smith, T. K. May 2014 In : Molecular Microbiology. 92, 3, p. 453-470 18 p.

    Research output: Contribution to journalArticle

  17. Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase

    Roberts, A. J., Torrie, L. S., Wyllie, S. & Fairlamb, A. H. 15 Apr 2014 In : Biochemical Journal. 459, 2, p. 323-332 10 p.

    Research output: Contribution to journalArticle

  18. Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy

    Wishart, T. M. , Mutsaers, C. A. , Riessland, M. , Reimer, M. M. , Hunter, G. , Hannam, M. L. , Eaton, S. L. , Fuller, H. R. , Roche, S. L. , Somers, E. , Morse, R. , Young, P. J. , Lamont, D. J. , Hammerschmidt, M. , Joshi, A. , Hohenstein, P. , Morris, G. E. , Parson, S. H. , Skehel, P. A. , Becker, T. & 4 others Robinson, I. M., Becker, C. G., Wirth, B. & Gillingwater, T. H. 1 Apr 2014 In : Journal of Clinical Investigation. 124, 4, p. 1821-1834 14 p.

    Research output: Contribution to journalArticle

  19. A novel marker, ARM58, confers antimony resistance to Leishmania spp

    Nuhs, A., Schäfer, C., Zander, D., Trübe, L., Tejera Nevado, P., Schmidt, S., Arevalo, J., Adaui, V., Maes, L., Dujardin, J-C. & Clos, J. Apr 2014 In : International Journal for Parasitology: Drugs and Drug Resistance. 4, 1, p. 37-47 11 p.

    Research output: Contribution to journalArticle

  20. Structure of a rare non-standard sequence k-turn bound by L7Ae protein

    Huang, L. & Lilley, D. M. J. Apr 2014 In : Nucleic Acids Research. 42, 7, p. 4734-4740 7 p.

    Research output: Contribution to journalArticle

  21. The k-junction motif in RNA structure

    Wang, J., Daldrop, P., Huang, L. & Lilley, D. M. J. Apr 2014 In : Nucleic Acids Research. 42, 8, p. 5322-5331 10 p.

    Research output: Contribution to journalArticle

  22. Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase

    Urbaniak, M. D., Capes, A. S., Crossman, A., O'Neill, S., Thompson, S., Gilbert, I. H. & Ferguson, M. A. J. 31 Mar 2014 In : Carbohydrate Research. 387, p. 54-58 5 p.

    Research output: Contribution to journalArticle

  23. Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei

    Damerow, M., Rodrigues, J. A., Wu, D., Güther, M. L. S., Mehlert, A. & Ferguson, M. A. J. 28 Mar 2014 In : Journal of Biological Chemistry. 289, 13, p. 9328-9339 12 p.

    Research output: Contribution to journalArticle

  24. How the structure of the large subunit controls function in an oxygen-tolerant [NiFe]-hydrogenase

    Bowman, L., Flanagan, L., Fyfe, P. K., Parkin, A., Hunter, W. N. & Sargent, F. 15 Mar 2014 In : Biochemical Journal. 458, 3, p. 449-458 10 p.

    Research output: Contribution to journalArticle

  25. High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei.

    McGregor, P., Ivens, A., Shave, S., Collie, I., Gray, D., Auer, M. & Matthews, K. R. Mar 2014 In : Eukaryotic Cell. 13, 3, p. 412-426 15 p.

    Research output: Contribution to journalArticle

  26. Predicting hydration free energies with chemical accuracy: the SAMPL4 challenge

    Sandberg, L. Mar 2014 In : Journal of Computer-Aided Molecular Design. 28, 3, p. 211-219 9 p.

    Research output: Contribution to journalArticle

  27. Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues

    Capes, A. S., Crossman, A., Urbaniak, M. D., Gilbert, S. H., Ferguson, M. A. J. & Gilbert, I. H. Mar 2014 In : Organic and Biomolecular Chemistry. 12, 12, p. 1919-1934 16 p.

    Research output: Contribution to journalArticle

  28. Norspermidine is not a self-produced trigger for biofilm disassembly

    Hobley, L., Kim, S. H., Maezato, Y., Wyllie, S., Fairlamb, A. H., Stanley-Wall, N. R. & Michael, A. J. 13 Feb 2014 In : Cell. 156, 4, p. 844-854 11 p.

    Research output: Contribution to journalArticle

  29. Evolution of the nucleus

    Devos, D. P., Gräf, R. & Field, M. C. 5 Feb 2014 In : Current Opinion in Cell Biology. 28, p. 8-15 8 p.

    Research output: Contribution to journalArticle

  30. Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors

    Borodkin, V. S., Schimpl, M., Gundogdu, M., Rafie, K., Dorfmueller, H. C., Robinson, D. A. & van Aalten, D. M. F. 1 Feb 2014 In : Biochemical Journal. 457, 3, p. 497-502 6 p.

    Research output: Contribution to journalArticle

  31. The cyclic AMP phosphodiesterase RegA critically regulates encystation in social and pathogenic amoebas

    Du, Q., Schilde, C., Birgersson, E., Chen, Z-H., McElroy, S. & Schaap, P. Feb 2014 In : Cellular Signalling. 26, 2, p. 453-459 7 p.

    Research output: Contribution to journalArticle

  32. Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei

    Mony, B. M., MacGregor, P., Ivens, A., Rojas, F., Cowton, A., Young, J., Horn, D. & Matthews, K. 30 Jan 2014 In : Nature. 505, 7485, p. 681-685 5 p.

    Research output: Contribution to journalLetter

  33. In Vitro and In Vivo studies of trypanocidal activity of dietary isothiocyanates

    Steverding, D., Michaels, S. & Read, K. D. 22 Jan 2014 In : Planta Medica.

    Research output: Contribution to journalLetter

  34. Is NMR fragment screening fine-tuned to assess druggability of protein-protein interactions?

    Dias, D. M., Van Molle, I., Baud, M. G. J., Galdeano, C., Geraldes, C. F. G. C. & Ciulli, A. 9 Jan 2014 In : ACS Medicinal Chemistry Letters. 5, 1, p. 23-28 6 p.

    Research output: Contribution to journalLetter

  35. Crystals on the cover 2014

    Einspahr, H., Weiss, M. S. & Hunter, W. N. Jan 2014 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 70, 1, p. 1 1 p.

    Research output: Contribution to journalEditorial

  36. A structural and biochemical model of processive chitin synthesis

    Dorfmueller, H. C., Ferenbach, A. T., Borodkin, V. S. & van Aalten, D. M. F. 2014 In : Journal of Biological Chemistry.

    Research output: Contribution to journalArticle

  37. ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome

    Tinti, M., Madeira, F., Murugesan, G., Hoxhaj, G., Toth, R. & Mackintosh, C. 2014 In : Database: the Journal of Biological Databases and Curation. 2014, 15 p.bat085

    Research output: Contribution to journalArticle

  38. Antiparasitic chemotherapy: from genomes to mechanisms

    Horn, D. & Duraisingh, M. T. 2014 In : Annual Review of Pharmacology and Toxicology. 54, p. 71-94 24 p.

    Research output: Contribution to journalArticle

  39. Characterisation of a melamino nitroheterocycle as a potential lead for the treatment of human African trypanosomiasis

    Giordani, F., Buschini, A., Baliani, A., Kaiser, M., Brun, R., Barrett, M. P., Pellacani, C., Poli, P. & Gilbert, I. H. 2014 In : Antimicrobial Agents and Chemotherapy.

    Research output: Contribution to journalArticle

  40. Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ES cell differentiation without affecting naive to primed cell transition

    Speakman, C. M., Domke, T. C. E., Wongpaiboonwattana, W., Sanders, K., Mudaliar, M., van Aalten, D. M. F., Barton, G. J. & Stavridis, M. P. 2014 In : Stem Cells.

    Research output: Contribution to journalArticle

  41. Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors

    Casale, E., Amboldi, N., Brasca, . M. G., Caronni, D., Colombo, N., Dalvit, C., Felder, E. R., Fogliatto, G., Galvani, A., Isacchi, A., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F. & Casuscelli, F. 2014 In : Bioorganic & Medicinal Chemistry. 22, 15, p. 4135-4150 16 p.

    Research output: Contribution to journalArticle

  42. Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains

    Kneuper, H., Cao, Z. P., Twomey, K. B., Zoltner, M., Jäger, F., Cargill, J. S., Chalmers, J., van der Kooi-Pol, M. M., van Dijl, J. M., Ryan, R. P., Hunter, W. N. & Palmer, T. 2014 In : Molecular Microbiology. 93, 5, p. 928-943 15 p.

    Research output: Contribution to journalArticle

  43. High-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC proteomics

    Güther, M. L. S., Urbaniak, M., Tavendale, A., Prescott, A. & Ferguson, M. A. J. 2014 In : Journal of Proteome Research. 13, 6, p. 2796-2806 11 p.

    Research output: Contribution to journalArticle

  44. Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers

    Tinti, M., Dissanayake, K., Synowsky, S., Albergante, L. & Mackintosh, C. 2014 In : Open Biology. 4, May, 16 p.140029

    Research output: Contribution to journalArticle

  45. Improved annotation of 3' untranslated regions and complex loci by combination of strand-specific direct RNA sequencing, RNA-seq and ESTs

    Schurch, N. J., Cole, C., Sherstnev, A., Song, J., Duc, C., Storey, K. G., McLean, W. H. I., Brown, S. J., Simpson, G. G. & Barton, G. J. 2014 In : PLoS ONE. 9, 4, e94270

    Research output: Contribution to journalArticle

  46. Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo

    Olivera-Martinez, I., Schurch, N., Li, R. A., Song, J., Halley, P. A., Das, R. M., Burt, D. W., Barton, G. J. & Storey, K. G. 2014 In : Development. 11 p.

    Research output: Contribution to journalArticle

  47. Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK

    Hunter, R. W., Foretz, M., Bultot, L., Fullerton, M. D., Deak, M., Ross, F. A., Hawley, S. A., Shpiro, N., Viollet, B., Barron, D., Kemp, B. E., Steinberg, G. R., Hardie, D. G. & Sakamoto, K. 2014 In : Chemistry & Biology. 21, 7, p. 866-879 14 p.

    Research output: Contribution to journalArticle

  48. Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects

    Patterson, S. & Wyllie, S. 2014 In : Trends in Parasitology. 30, 6, p. 289-298 10 p.

    Research output: Contribution to journalArticle

  49. Proteomic Selection of Immunodiagnostic Antigens for Trypanosoma congolense

    Fleming, J. R., Sastry, L., Crozier, T. W. M., Napier, G. B., Sullivan, L. & Ferguson, M. A. J. 2014 In : PLoS Neglected Tropical Diseases. 8, 6, e2936

    Research output: Contribution to journalArticle

  50. Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling

    Atrih, A., Mudaliar, M. A. V., Zakikhani, P., Lamont, D. J., Huang, J. T-J., Bray, S. E., Barton, G., Fleming, S. & Nabi, G. 2014 In : British Journal of Cancer. 110, 6, p. 1622-1633 12 p.

    Research output: Contribution to journalArticle

  51. Respiratory flexibility in response to inhibition of cytochrome C oxidase in Mycobacterium tuberculosis

    Arora, K., Ochoa-Montaño, B., Tsang, P. S., Blundell, T. L., Dawes, S. S., Mizrahi, V., Bayliss, T., Mackenzie, C. J., Cleghorn, L. A. T., Ray, P. C., Wyatt, P. G., Uh, E., Lee, J., Barry, C. E. & Boshoff, H. I. 2014 In : Antimicrobial Agents and Chemotherapy. 12 p.

    Research output: Contribution to journalArticle

  52. Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors

    Lockhart, D. E. A., Schuettelkopf, A., Blair, D. & van Aalten, D. M. F. 2014 In : FEBS Letters. 588, 17, p. 3282-3290 9 p.

    Research output: Contribution to journalArticle

  53. Standardizing biochemistry dataset for medical research

    Bonney, W., Doney, A. & Jefferson, E. 2014 HEALTHINF 2014 - 7th International Conference on Health Informatics, Proceedings; Part of 7th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2014. p. 205-210 6 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  54. Structure-based virtual screening for the identification of RNA-binding ligands

    Daldrop, P. & Brenk, R. 2014 Therapeutic applications of ribozymes and riboswitches: methods and protocols. Lafontaine, D. & Dubé, A. (eds.). Humana Press, p. 127-139 13 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  55. The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution

    Bowman, A., Hammond, C. M., Stirling, A., Ward, R., Shang, W., El-Mkami, H., Robinson, D. A., Svergun, D. I., Norman, D. G., Owen-Hughes, T. & Singh, V. 2014 In : Nucleic Acids Research. 42, 9, p. 6038-6051 13 p.

    Research output: Contribution to journalArticle

  56. The role of ligand efficiency metrics in drug discovery

    Hopkins, A. L., Keserü, G. M., Leeson, P. D., Rees, D. C. & Reynolds, C. H. 2014 In : Nature Reviews Drug Discovery. 13, 2, p. 105-121 17 p.

    Research output: Contribution to journalArticle

  57. Touching from a distance: evolution of interplay between the nuclear pore complex, nuclear basket, and the mitotic spindle

    Holden, J. M., Koreny, L., Kelly, S., Chait, B. T., Rout, M. P., Field, M. C. & Obado, S. O. 2014 In : Nucleus. 5, 4

    Research output: Contribution to journalArticle

  58. Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control

    Glover, L., Hutchinson, S., Alsford, S., McCulloch, R., Field, M. C. & Horn, D. Dec 2013 In : Cellular Microbiology. 15, 12, p. 1984-1993 10 p.

    Research output: Contribution to journalArticle

  59. Fragment-based hit identification: thinking in 3D

    Morley, A. D., Pugliese, A., Birchall, K., Bower, J., Brennan, P., Brown, N., Chapman, T., Drysdale, M., Gilbert, I. H., Hoelder, S., Jordan, A., Ley, S. V., Merritt, A., Miller, D., Swarbrick, M. E. & Wyatt, P. G. Dec 2013 In : Drug Discovery Today. 18, 23-24, p. 1221-1227 7 p.

    Research output: Contribution to journalArticle

  60. Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens

    Srikannathasan, V., English, G., Bui, N. K., Trunk, K., O'Rourke, P. E. F., Rao, V. A., Vollmer, W., Coulthurst, S. J. & Hunter, W. N. Dec 2013 In : Acta Crystallographica Section D: Biological Crystallography. 69, 12, p. 2468-2482 15 p.

    Research output: Contribution to journalArticle

  61. Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain

    Ferguson, F. M., Fedorov, O., Chaikuad, A., Philpott, M., Muniz, J. R. C., Felletar, I., von Delft, F., Heightman, T., Knapp, S., Abell, C. & Ciulli, A. Dec 2013 In : Journal of Medicinal Chemistry. 56, 24, p. 10183-10187 5 p.

    Research output: Contribution to journalArticle

  62. Two high-resolution structures of the human E3 ubiquitin ligase Siah1

    Rimsa, V., Eadsforth, T. C. & Hunter, W. N. Dec 2013 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 12, p. 1339-1343 5 p.

    Research output: Contribution to journalArticle

  63. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

    Brown, S. J. , Madhok, V. B. & 32 others Saunders, S. P., Goh, C. S. M., Palmer, C. N. A., Porter, R. M., Cole, C., Campbell, L. E., Gierlinski, M., Barton, G. J., Schneider, G., Balmain, A., Prescott, A. R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y-A., Tavendale, R., Mukhopadhyay, S., Turner, S. W., Sullivan, F. M., Relton, C., Burn, J., Meggitt, S., Smith, C. H., Allen, M. A., Barker, J. N. W. N., Reynolds, N. J., Cordell, H. J., Irvine, A. D., McLean, W. H. I., Sandilands, A. & Fallon, P. G. Nov 2013 In : Journal of Allergy and Clinical Immunology. 132, 5, p. 1121-1129 9 p.

    Research output: Contribution to journalArticle

  64. Construction of reference chromosome-scale pseudomolecules for potato: integrating the potato genome with genetic and physical maps

    Sharma, S. K. , Bolser, D. , de Boer, J. , Sønderkær, M. , Amoros, W. , Carboni, M. F. , D'Ambrosio, J. M. , de la Cruz, G. , Di Genova, A. , Douches, D. S. , Eguiluz, M. , Guo, X. , Guzman, F. , Hackett, C. A. , Hamilton, J. P. , Li, G. , Li, Y. , Lozano, R. , Maass, A. , Marshall, D. & 25 others Martinez, D., McLean, K., Mejía, N., Milne, L., Munive, S., Nagy, I., Ponce, O., Ramirez, M., Simon, R., Thomson, S. J., Torres, Y., Waugh, R., Zhang, Z., Huang, S., Visser, R. G. F., Bachem, C. W. B., Sagredo, B., Feingold, S. E., Orjeda, G., Veilleux, R. E., Bonierbale, M., Jacobs, J. M. E., Milbourne, D., Martin, D. M. A. & Bryan, G. J. Nov 2013 In : G3 : Genes, Genomes, Genetics. 3, 11, p. 2031-2047 17 p.

    Research output: Contribution to journalArticle

  65. Transcription Termination and Chimeric RNA Formation Controlled by Arabidopsis thaliana FPA

    Duc, C., Sherstnev, A., Cole, C., Barton, G. & Simpson, G. G. 31 Oct 2013 In : PLoS Genetics. 9, 10, e1003867

    Research output: Contribution to journalArticle

  66. Anti-malarial agents

    Gilbert, I., Norcross, N., Baragana, B. & Porzelle, A. 17 Oct 2013 PCT/GB2013/050633

    Research output: Patent

  67. The RNA-binding protein FPA regulates flg22-triggered defense responses and transcription factor activity by alternative polyadenylation

    Lyons, R., Iwase, A., Gänsewig, T., Sherstnev, A., Duc, C., Barton, G. J., Hanada, K., Higuchi-Takeuchi, M., Matsui, M., Sugimoto, K., Kazan, K., Simpson, G. G. & Shirasu, K. 9 Oct 2013 In : Scientific Reports. 3, 10 p.2866

    Research output: Contribution to journalArticle

  68. Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain

    Rao, F. V., Schüttelkopf, A. W., Dorfmueller, H. C., Ferenbach, A. T., Navratilova, I. & van Aalten, D. M. F. 2 Oct 2013 In : Open Biology. 3, 130021

    Research output: Contribution to journalArticle

  69. Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy

    Ong, H. B., Sienkiewicz, N., Wyllie, S., Patterson, S. & Fairlamb, A. H. Oct 2013 In : Molecular Microbiology. 90, 2, p. 443-455 13 p.

    Research output: Contribution to journalArticle

  70. Drug discovery for the treatment of leishmaniasis, African sleeping sickness and Chagas disease

    Avery, V., Buckner, F., Baell, J., Fairlamb, A., Michels, P. A. & Tarleton, R. Oct 2013 In : Future Medicinal Chemistry. 5, 15, p. 1709-1718 10 p.

    Research output: Contribution to journalArticle

  71. The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

    Patterson, S., Wyllie, S., Stojanovski, L., Perry, M. R., Simeons, F. R. C., Norval, S., Osuna-Cabello, M., De Rycker, M., Read, K. D. & Fairlamb, A. H. Oct 2013 In : Antimicrobial Agents and Chemotherapy. 57, 10, p. 4699-4706 8 p.

    Research output: Contribution to journalArticle

  72. A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei

    Urbaniak, M. D., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Navratilova, I. H., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J. 20 Sep 2013 In : ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.

    Research output: Contribution to journalArticle

  73. Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase

    Hampton, S. E., Schipani, A., Bosch-Navarrete, C., Recio, E., Kaiser, M., Kahnberg, P., González-Pacanowska, D., Johansson, N. G. & Gilbert, I. H. 15 Sep 2013 In : Bioorganic & Medicinal Chemistry. 21, 18, p. 5876-5885 10 p.

    Research output: Contribution to journalArticle

  74. Yeast Mnn9 is both a priming glycosyltransferase and an allosteric activator of mannan biosynthesis

    Striebeck, A., Robinson, D. A., Schüttelkopf, A. W. & van Aalten, D. M. F. Sep 2013 In : Open Biology. 3, 9, 130022

    Research output: Contribution to journalArticle

  75. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery

    Silvestre, H. L., Blundell, T. L., Abell, C. & Ciulli, A. 6 Aug 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 32, p. 12984-12989 6 p.

    Research output: Contribution to journalArticle

  76. Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target

    Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Urbaniak, M. D., Ibrahim, A. F. M., Ferguson, M. A. J., Jin, C. & van Aalten, D. M. F. Aug 2013 In : Molecular Microbiology. 89, 3, p. 479-493 15 p.

    Research output: Contribution to journalArticle

  77. Multimeric complexes among Ankyrin-Repeat and SOCS-box Protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 Ubiquitin Ligases

    Thomas, J. C., Matak-Vinkovic, D., Van Molle, I. & Ciulli, A. 25 Jul 2013 In : Biochemistry. 52, 31, p. 5236-5246 11 p.

    Research output: Contribution to journalArticle

  78. Structure of the SCAN domain of human paternally expressed gene 3 protein

    Rimsa, V., Eadsforth, T. C. & Hunter, W. N. 23 Jul 2013 In : PLoS ONE. 8, 7, e69538

    Research output: Contribution to journalArticle

  79. Genetic and structural validation of Aspergillus fumigatus N-acetylphosphoglucosamine mutase as an antifungal target

    Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Mariño, K., Ibrahim, A. F. M., Albarbarawi, O., Ferguson, M. A. J., Jin, C. & Van Aalten, D. M. F. 11 Jul 2013 In : Bioscience Reports. 33, 5, 11 p.e00063

    Research output: Contribution to journalArticle

  80. Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.

    De Rycker, M., Hallyburton, I., Thomas, J., Campbell, L., Wyllie, S., Joshi, D., Cameron, S., Gilbert, I. H., Wyatt, P. G., Frearson, J. A., Fairlamb, A. H. & Gray, D. W. Jul 2013 In : Antimicrobial Agents and Chemotherapy. 57, 7, p. 2913-2922 10 p.

    Research output: Contribution to journalArticle

  81. From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules

    Woodland, A., Grimaldi, R., Luksch, T., Cleghorn, L. A. T., Ojo, K. K., Van Voorhis, W. C., Brenk, R., Frearson, J. A., Gilbert, I. H. & Wyatt, P. G. Jul 2013 In : ChemMedChem. 8, 7, p. 1127-1137 11 p.

    Research output: Contribution to journalArticle

  82. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins

    Gabernet-Castello, C., O'Reilly, A. J., Dacks, J. B. & Field, M. C. 15 May 2013 In : Molecular Biology of the Cell. 24, 10, p. 1574-1583 10 p.

    Research output: Contribution to journalArticle

  83. A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle

    Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., Shattock, M. J., Calaghan, S. C. & Fuller, W. 10 May 2013 In : Journal of Biological Chemistry. 288, 19, p. 13808-13820 13 p.

    Research output: Contribution to journalArticle

  84. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

    Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P. 1 May 2013 In : Biochemical Journal. 451, 3, p. 427-437 11 p.

    Research output: Contribution to journalArticle

  85. De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments

    Urich, R., Wishart, G., Kiczun, M., Richters, A., Tidten-Luksch, N., Rauh, D., Sherborne, B., Wyatt, P. G. & Brenk, R. May 2013 In : ACS Chemical Biology. 8, 5, p. 1044-1052 9 p.

    Research output: Contribution to journalArticle

  86. Evolution of modular intraflagellar transport from a coatomer-like progenitor

    van Dam, T. J. P., Townsend, M. J., Turk, M., Schlessinger, A., Sali, A., Field, M. C. & Huynen, M. A. 23 Apr 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 17, p. 6943-6948 6 p.

    Research output: Contribution to journalArticle

  87. Structure of a complex phosphoglycan epitope from gp72 of Trypanosoma cruzi

    Allen, S., Richardson, J. M., Mehlert, A. & Ferguson, M. A. J. 19 Apr 2013 In : Journal of Biological Chemistry. 288, 16, p. 11093-11105 13 p.

    Research output: Contribution to journalArticle

  88. Improved sperm function / activity

    Barratt, C. & Wyatt, P. 18 Apr 2013 WO2013054111 A1

    Research output: Patent

  89. Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria

    Gargiulo, L., Papaioannou, M., Sica, M., Talini, G., Chaidos, A., Richichi, B., Nikolaev, A. V., Nativi, C., Layton, M., de la Fuente, J., Roberts, I., Luzzatto, L., Notaro, R. & Karadimitris, A. 4 Apr 2013 In : Blood. 121, 14, p. 2753-2761 9 p.

    Research output: Contribution to journalArticle

  90. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

    Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3 Apr 2013 In : EMBO Journal. 32, 7, p. 1008-22 15 p.

    Research output: Contribution to journalArticle

  91. The architecture of EssB, an integral membrane component of the type VII secretion system

    Zoltner, M., Norman, D. G., Fyfe, P. K., El Mkami, H., Palmer, T. & Hunter, W. N. 2 Apr 2013 In : Structure. 21, 4, p. 595-603 9 p.

    Research output: Contribution to journalArticle

  92. Proteomic analysis of clathrin interactions in trypanosomes reveals dynamic evolution of endocytosis

    Adung'a, V. O., Gadelha, C. & Field, M. C. Apr 2013 In : Traffic. 14, 4, p. 440-457 18 p.

    Research output: Contribution to journalScientific review

  93. DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes

    Glover, L., Alsford, S. & Horn, D. Mar 2013 In : PLoS Pathogens. 9, 3, 15 p.ARTN e1003260

    Research output: Contribution to journalArticle

  94. Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story

    Baker, N., de Koning, H. P., Maeser, P. & Horn, D. Mar 2013 In : Trends in Parasitology. 29, 3, p. 110-118 9 p.

    Research output: Contribution to journalScientific review

  95. The functional exchangeability of pk- and k-turns in RNA structure

    Daldrop, P., Masquida, B. & Lilley, D. M. J. Mar 2013 In : RNA Biology. 10, 3, p. 445-452 8 p.

    Research output: Contribution to journalArticle

  96. The importance of the N-terminus of T7 endonuclease I in the interaction with DNA junctions

    Freeman, A. D. J., Déclais, A-C. & Lilley, D. M. J. 23 Jan 2013 In : Journal of Molecular Biology. 425, 2, p. 395-410 16 p.

    Research output: Contribution to journalArticle

  97. Characterization of Staphylococcus aureus EssB, an integral membrane component of the Type VII secretion system: atomic resolution crystal structure of the cytoplasmic segment

    Zoltner, M., Fyfe, P. K., Palmer, T. & Hunter, W. N. 15 Jan 2013 In : Biochemical Journal. 449, 2, p. 469-477 9 p.

    Research output: Contribution to journalArticle

  98. PGE2 induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway

    Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15 Jan 2013 In : Journal of Immunology. 190, 2, p. 565-577 13 p.

    Research output: Contribution to journalArticle

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