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  1. TbGT8 is a bifunctional glycosyltransferase that elaborates N-linked glycans on a protein phosphatase AcP115 and a GPI-anchor modifying glycan in Trypanosoma brucei

    Nakanishi, M., Karasudani, M., Shiraishi, T., Hashida, K., Hino, M., Ferguson, M. A. J. & Nomoto, H. Jun 2014 In : Parasitology International. 63, 3, p. 513-518 6 p.

    Research output: Contribution to journalArticle

  2. Improved annotation of 3' untranslated regions and complex loci by combination of strand-specific direct RNA sequencing, RNA-seq and ESTs

    Schurch, N. J., Cole, C., Sherstnev, A., Song, J., Duc, C., Storey, K. G., McLean, W. H. I., Brown, S. J., Simpson, G. G. & Barton, G. J. 10 Apr 2014 In : PLoS ONE. 9, 4, e94270

    Research output: Contribution to journalArticle

  3. Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase

    Urbaniak, M. D., Capes, A. S., Crossman, A., O'Neill, S., Thompson, S., Gilbert, I. H. & Ferguson, M. A. J. 31 Mar 2014 In : Carbohydrate Research. 387, p. 54-58 5 p.

    Research output: Contribution to journalArticle

  4. Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues

    Capes, A. S., Crossman, A., Urbaniak, M. D., Gilbert, S. H., Ferguson, M. A. J. & Gilbert, I. H. Mar 2014 In : Organic and Biomolecular Chemistry. 12, 12, p. 1919-1934 16 p.

    Research output: Contribution to journalArticle

  5. Norspermidine is not a self-produced trigger for biofilm disassembly

    Hobley, L., Kim, S. H., Maezato, Y., Wyllie, S., Fairlamb, A. H., Stanley-Wall, N. R. & Michael, A. J. 13 Feb 2014 In : Cell. 156, 4, p. 844-854 11 p.

    Research output: Contribution to journalArticle

  6. Evolution of the nucleus

    Devos, D. P., Gräf, R. & Field, M. C. 5 Feb 2014 In : Current Opinion in Cell Biology. 28, p. 8-15 8 p.

    Research output: Contribution to journalArticle

  7. Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors

    Borodkin, V. S., Schimpl, M., Gundogdu, M., Rafie, K., Dorfmueller, H. C., Robinson, D. A. & van Aalten, D. M. F. 1 Feb 2014 In : Biochemical Journal. 457, 3, p. 497-502 6 p.

    Research output: Contribution to journalArticle

  8. The cyclic AMP phosphodiesterase RegA critically regulates encystation in social and pathogenic amoebas

    Du, Q., Schilde, C., Birgersson, E., Chen, Z-H., McElroy, S. & Schaap, P. Feb 2014 In : Cellular Signalling. 26, 2, p. 453-459 7 p.

    Research output: Contribution to journalArticle

  9. Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei

    Mony, B. M., MacGregor, P., Ivens, A., Rojas, F., Cowton, A., Young, J., Horn, D. & Matthews, K. 30 Jan 2014 In : Nature. 505, 7485, p. 681-685 5 p.

    Research output: Contribution to journalLetter

  10. In Vitro and In Vivo studies of trypanocidal activity of dietary isothiocyanates

    Steverding, D., Michaels, S. & Read, K. D. 22 Jan 2014 In : Planta Medica.

    Research output: Contribution to journalLetter

  11. Is NMR fragment screening fine-tuned to assess druggability of protein-protein interactions?

    Dias, D. M., Van Molle, I., Baud, M. G. J., Galdeano, C., Geraldes, C. F. G. C. & Ciulli, A. 9 Jan 2014 In : ACS Medicinal Chemistry Letters. 5, 1, p. 23-28 6 p.

    Research output: Contribution to journalLetter

  12. Crystals on the cover 2014

    Einspahr, H., Weiss, M. S. & Hunter, W. N. Jan 2014 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 70, 1, p. 1 1 p.

    Research output: Contribution to journalEditorial

  13. A novel marker, ARM58, confers antimony resistance to Leishmania spp

    Nuhs, A., Schäfer, C., Zander, D., Trübe, L., Tejera Nevado, P., Schmidt, S., Arevalo, J., Adaui, V., Maes, L., Dujardin, J-C. & Clos, J. 2014 In : International Journal for Parasitology: Drugs and Drug Resistance. 4, 1, p. 37-47 11 p.

    Research output: Contribution to journalArticle

  14. Antiparasitic chemotherapy: from genomes to mechanisms

    Horn, D. & Duraisingh, M. T. 2014 In : Annual Review of Pharmacology and Toxicology. 54, p. 71-94 24 p.

    Research output: Contribution to journalArticle

  15. Structure of a rare non-standard sequence k-turn bound by L7Ae protein

    Huang, L. & Lilley, D. M. J. 2014 In : Nucleic Acids Research.

    Research output: Contribution to journalArticle

  16. Structure-based virtual screening for the identification of RNA-binding ligands

    Daldrop, P. & Brenk, R. 2014 Therapeutic applications of ribozymes and riboswitches: methods and protocols. Lafontaine, D. & Dubé, A. (eds.). Humana Press, p. 127-139 13 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  17. The role of ligand efficiency metrics in drug discovery

    Hopkins, A. L., Keserü, G. M., Leeson, P. D., Rees, D. C. & Reynolds, C. H. 2014 In : Nature Reviews Drug Discovery. 13, 2, p. 105-121 17 p.

    Research output: Contribution to journalArticle

  18. Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control

    Glover, L., Hutchinson, S., Alsford, S., McCulloch, R., Field, M. C. & Horn, D. Dec 2013 In : Cellular Microbiology. 15, 12, p. 1984-1993 10 p.

    Research output: Contribution to journalArticle

  19. Fragment-based hit identification: thinking in 3D

    Morley, A. D., Pugliese, A., Birchall, K., Bower, J., Brennan, P., Brown, N., Chapman, T., Drysdale, M., Gilbert, I. H., Hoelder, S., Jordan, A., Ley, S. V., Merritt, A., Miller, D., Swarbrick, M. E. & Wyatt, P. G. Dec 2013 In : Drug Discovery Today. 18, 23-24, p. 1221-1227 7 p.

    Research output: Contribution to journalArticle

  20. Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens

    Srikannathasan, V., English, G., Bui, N. K., Trunk, K., O'Rourke, P. E. F., Rao, V. A., Vollmer, W., Coulthurst, S. J. & Hunter, W. N. Dec 2013 In : Acta Crystallographica Section D: Biological Crystallography. 69, 12, p. 2468-2482 15 p.

    Research output: Contribution to journalArticle

  21. Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain

    Ferguson, F. M., Fedorov, O., Chaikuad, A., Philpott, M., Muniz, J. R. C., Felletar, I., von Delft, F., Heightman, T., Knapp, S., Abell, C. & Ciulli, A. Dec 2013 In : Journal of Medicinal Chemistry. 56, 24, p. 10183-10187 5 p.

    Research output: Contribution to journalArticle

  22. Two high-resolution structures of the human E3 ubiquitin ligase Siah1

    Rimsa, V., Eadsforth, T. C. & Hunter, W. N. Dec 2013 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 12, p. 1339-1343 5 p.

    Research output: Contribution to journalArticle

  23. Construction of reference chromosome-scale pseudomolecules for potato: integrating the potato genome with genetic and physical maps

    Sharma, S. K. , Bolser, D. , de Boer, J. , Sønderkær, M. , Amoros, W. , Carboni, M. F. , D'Ambrosio, J. M. , de la Cruz, G. , Di Genova, A. , Douches, D. S. , Eguiluz, M. , Guo, X. , Guzman, F. , Hackett, C. A. , Hamilton, J. P. , Li, G. , Li, Y. , Lozano, R. , Maass, A. , Marshall, D. & 25 others Martinez, D., McLean, K., Mejía, N., Milne, L., Munive, S., Nagy, I., Ponce, O., Ramirez, M., Simon, R., Thomson, S. J., Torres, Y., Waugh, R., Zhang, Z., Huang, S., Visser, R. G. F., Bachem, C. W. B., Sagredo, B., Feingold, S. E., Orjeda, G., Veilleux, R. E., Bonierbale, M., Jacobs, J. M. E., Milbourne, D., Martin, D. M. A. & Bryan, G. J. 1 Nov 2013 In : G3 : Genes, Genomes, Genetics. 3, 11, p. 2031-2047 17 p.

    Research output: Contribution to journalArticle

  24. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

    Madhok, V. B. & 33 others Saunders, S. P., Goh, C. S. M., Brown, S. J., Palmer, C. N. A., Porter, R. M., Cole, C., Campbell, L. E., Gierlinski, M., Barton, G. J., Schneider, G., Balmain, A., Prescott, A. R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y-A., Tavendale, R., Mukhopadhyay, S., Turner, S. W., Sullivan, F. M., Relton, C., Burn, J., Meggitt, S., Smith, C. H., Allen, M. A., Barker, J. N. W. N., Reynolds, N. J., Cordell, H. J., Irvine, A. D., McLean, W. H. I., Sandilands, A. & Fallon, P. G. Nov 2013 In : Journal of Allergy and Clinical Immunology. 132, 5, p. 1121-1129 9 p.

    Research output: Contribution to journalArticle

  25. Transcription Termination and Chimeric RNA Formation Controlled by Arabidopsis thaliana FPA

    Duc, C., Sherstnev, A., Cole, C., Barton, G. & Simpson, G. G. 31 Oct 2013 In : PLoS Genetics. 9, 10, e1003867

    Research output: Contribution to journalArticle

  26. Anti-malarial agents

    Gilbert, I., Norcross, N., Baragana, B. & Porzelle, A. 17 Oct 2013 PCT/GB2013/050633

    Research output: Patent

  27. The RNA-binding protein FPA regulates flg22-triggered defense responses and transcription factor activity by alternative polyadenylation

    Lyons, R., Iwase, A., Gänsewig, T., Sherstnev, A., Duc, C., Barton, G. J., Hanada, K., Higuchi-Takeuchi, M., Matsui, M., Sugimoto, K., Kazan, K., Simpson, G. G. & Shirasu, K. 9 Oct 2013 In : Scientific Reports. 3, 10 p.2866

    Research output: Contribution to journalArticle

  28. Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain

    Rao, F. V., Schüttelkopf, A. W., Dorfmueller, H. C., Ferenbach, A. T., Navratilova, I. & van Aalten, D. M. F. 2 Oct 2013 In : Open Biology. 3, 130021

    Research output: Contribution to journalArticle

  29. Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy

    Ong, H. B., Sienkiewicz, N., Wyllie, S., Patterson, S. & Fairlamb, A. H. Oct 2013 In : Molecular Microbiology. 90, 2, p. 443-455 13 p.

    Research output: Contribution to journalArticle

  30. Drug discovery for the treatment of leishmaniasis, African sleeping sickness and Chagas disease

    Avery, V., Buckner, F., Baell, J., Fairlamb, A., Michels, P. A. & Tarleton, R. Oct 2013 In : Future Medicinal Chemistry. 5, 15, p. 1709-1718 10 p.

    Research output: Contribution to journalArticle

  31. The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

    Patterson, S., Wyllie, S., Stojanovski, L., Perry, M. R., Simeons, F. R. C., Norval, S., Osuna-Cabello, M., De Rycker, M., Read, K. D. & Fairlamb, A. H. Oct 2013 In : Antimicrobial Agents and Chemotherapy. 57, 10, p. 4699-4706 8 p.

    Research output: Contribution to journalArticle

  32. A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei

    Urbaniak, M. D., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Navratilova, I. H., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J. 20 Sep 2013 In : ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.

    Research output: Contribution to journalArticle

  33. Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase

    Hampton, S. E., Schipani, A., Bosch-Navarrete, C., Recio, E., Kaiser, M., Kahnberg, P., González-Pacanowska, D., Johansson, N. G. & Gilbert, I. H. 15 Sep 2013 In : Bioorganic & Medicinal Chemistry. 21, 18, p. 5876-5885 10 p.

    Research output: Contribution to journalArticle

  34. Yeast Mnn9 is both a priming glycosyltransferase and an allosteric activator of mannan biosynthesis

    Striebeck, A., Robinson, D. A., Schüttelkopf, A. W. & van Aalten, D. M. F. Sep 2013 In : Open Biology. 3, 9, 130022

    Research output: Contribution to journalArticle

  35. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery

    Silvestre, H. L., Blundell, T. L., Abell, C. & Ciulli, A. 6 Aug 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 32, p. 12984-12989 6 p.

    Research output: Contribution to journalArticle

  36. Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target

    Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Urbaniak, M. D., Ibrahim, A. F. M., Ferguson, M. A. J., Jin, C. & van Aalten, D. M. F. Aug 2013 In : Molecular Microbiology. 89, 3, p. 479-493 15 p.

    Research output: Contribution to journalArticle

  37. Multimeric complexes among Ankyrin-Repeat and SOCS-box Protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 Ubiquitin Ligases

    Thomas, J. C., Matak-Vinkovic, D., Van Molle, I. & Ciulli, A. 25 Jul 2013 In : Biochemistry. 52, 31, p. 5236-5246 11 p.

    Research output: Contribution to journalArticle

  38. Structure of the SCAN domain of human paternally expressed gene 3 protein

    Rimsa, V., Eadsforth, T. C. & Hunter, W. N. 23 Jul 2013 In : PLoS ONE. 8, 7, e69538

    Research output: Contribution to journalArticle

  39. Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.

    De Rycker, M., Hallyburton, I., Thomas, J., Campbell, L., Wyllie, S., Joshi, D., Cameron, S., Gilbert, I. H., Wyatt, P. G., Frearson, J. A., Fairlamb, A. H. & Gray, D. W. Jul 2013 In : Antimicrobial Agents and Chemotherapy. 57, 7, p. 2913-2922 10 p.

    Research output: Contribution to journalArticle

  40. From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules

    Woodland, A., Grimaldi, R., Luksch, T., Cleghorn, L. A. T., Ojo, K. K., Van Voorhis, W. C., Brenk, R., Frearson, J. A., Gilbert, I. H. & Wyatt, P. G. Jul 2013 In : ChemMedChem. 8, 7, p. 1127-1137 11 p.

    Research output: Contribution to journalArticle

  41. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins

    Gabernet-Castello, C., O'Reilly, A. J., Dacks, J. B. & Field, M. C. 15 May 2013 In : Molecular Biology of the Cell. 24, 10, p. 1574-1583 10 p.

    Research output: Contribution to journalArticle

  42. A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle

    Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., Shattock, M. J., Calaghan, S. C. & Fuller, W. 10 May 2013 In : Journal of Biological Chemistry. 288, 19, p. 13808-13820 13 p.

    Research output: Contribution to journalArticle

  43. Global quantitative SILAC phosphoproteomics reveals differential phosphorylation is widespread between the procyclic and bloodstream form lifecycle stages of Trypanosoma brucei

    Urbaniak, M. D., Martin, D. M. A. & Ferguson, M. A. J. 3 May 2013 In : Journal of Proteome Research. 12, 5, p. 2233-2244 12 p.

    Research output: Contribution to journalArticle

  44. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

    Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P. 1 May 2013 In : Biochemical Journal. 451, 3, p. 427-437 11 p.

    Research output: Contribution to journalArticle

  45. De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments

    Urich, R., Wishart, G., Kiczun, M., Richters, A., Tidten-Luksch, N., Rauh, D., Sherborne, B., Wyatt, P. G. & Brenk, R. May 2013 In : ACS Chemical Biology. 8, 5, p. 1044-1052 9 p.

    Research output: Contribution to journalArticle

  46. Evolution of modular intraflagellar transport from a coatomer-like progenitor

    van Dam, T. J. P., Townsend, M. J., Turk, M., Schlessinger, A., Sali, A., Field, M. C. & Huynen, M. A. 23 Apr 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 17, p. 6943-6948 6 p.

    Research output: Contribution to journalArticle

  47. Structure of a complex phosphoglycan epitope from gp72 of Trypanosoma cruzi

    Allen, S., Richardson, J. M., Mehlert, A. & Ferguson, M. A. J. 19 Apr 2013 In : Journal of Biological Chemistry. 288, 16, p. 11093-11105 13 p.

    Research output: Contribution to journalArticle

  48. Improved sperm function / activity

    Barratt, C. & Wyatt, P. 18 Apr 2013 WO2013054111 A1

    Research output: Patent

  49. Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria

    Gargiulo, L., Papaioannou, M., Sica, M., Talini, G., Chaidos, A., Richichi, B., Nikolaev, A. V., Nativi, C., Layton, M., de la Fuente, J., Roberts, I., Luzzatto, L., Notaro, R. & Karadimitris, A. 4 Apr 2013 In : Blood. 121, 14, p. 2753-2761 9 p.

    Research output: Contribution to journalArticle

  50. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

    Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3 Apr 2013 In : EMBO Journal. 32, 7, p. 1008-22 15 p.

    Research output: Contribution to journalArticle

  51. The architecture of EssB, an integral membrane component of the type VII secretion system

    Zoltner, M., Norman, D. G., Fyfe, P. K., El Mkami, H., Palmer, T. & Hunter, W. N. 2 Apr 2013 In : Structure. 21, 4, p. 595-603 9 p.

    Research output: Contribution to journalArticle

  52. Proteomic analysis of clathrin interactions in trypanosomes reveals dynamic evolution of endocytosis

    Adung'a, V. O., Gadelha, C. & Field, M. C. Apr 2013 In : Traffic. 14, 4, p. 440-457 18 p.

    Research output: Contribution to journalScientific review

  53. DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes

    Glover, L., Alsford, S. & Horn, D. Mar 2013 In : PLoS Pathogens. 9, 3, 15 p.ARTN e1003260

    Research output: Contribution to journalArticle

  54. Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story

    Baker, N., de Koning, H. P., Maeser, P. & Horn, D. Mar 2013 In : Trends in Parasitology. 29, 3, p. 110-118 9 p.

    Research output: Contribution to journalScientific review

  55. The functional exchangeability of pk- and k-turns in RNA structure

    Daldrop, P., Masquida, B. & Lilley, D. M. J. Mar 2013 In : RNA Biology. 10, 3, p. 445-452 8 p.

    Research output: Contribution to journalArticle

  56. The importance of the N-terminus of T7 endonuclease I in the interaction with DNA junctions

    Freeman, A. D. J., Déclais, A-C. & Lilley, D. M. J. 23 Jan 2013 In : Journal of Molecular Biology. 425, 2, p. 395-410 16 p.

    Research output: Contribution to journalArticle

  57. Characterization of Staphylococcus aureus EssB, an integral membrane component of the Type VII secretion system: atomic resolution crystal structure of the cytoplasmic segment

    Zoltner, M., Fyfe, P. K., Palmer, T. & Hunter, W. N. 15 Jan 2013 In : Biochemical Journal. 449, 2, p. 469-477 9 p.

    Research output: Contribution to journalArticle

  58. PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway

    Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15 Jan 2013 In : Journal of Immunology. 190, 2, p. 565-77 13 p.

    Research output: Contribution to journalArticle

  59. Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

    Munday, J. C., Eze, A. A., Baker, N., Glover, L., Clucas, C., Aguinaga Andrés, D., Natto, M. J., Teka, I. A., McDonald, J., Lee, R. S., Graf, F. E., Ludin, P., Burchmore, R. J. S., Turner, C. M. R., Tait, A., MacLeod, A., Mäser, P., Barrett, M. P., Horn, D. & De Koning, H. P. 2013 In : Journal of Antimicrobial Chemotherapy.

    Research output: Contribution to journalArticle

  60. A Lack of premature termination codon read-through efficacy of PTC124 (Ataluren) in a diverse array of reporter assays

    McElroy, S. P., Nomura, T., Torrie, L. S., Warbrick, E., Gartner, U., Wood, G. & McLean, W. H. I. 2013 In : PLoS Biology. 11, 6, e1001593

    Research output: Contribution to journalArticle

  61. A mechanistic comparison of the varkud satellite and hairpin ribozymes

    Wilson, T. J. & Lilley, D. M. J. 2013 Catalytic RNA. Soukup, G. A. (ed.). London: Academic Press, p. 93-121 29 p. (Progress in molecular biology and translational science).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  62. A nonsense mutation in the mattrin gene causes the matted mouse phenotype and is a predisposing gene for atopic dermatitis in humans

    Goh, C. S., Saunders, S. P., Cole, C., Weidinger, S., Baurecht, H., Lee, Y., Reynolds, N. J., Barker, J. N., Cordell, H. J., Brown, S. J., Irvine, A. D., McLean, I., Sandilands, A. & Fallon, P. G. 2013 In : Journal of Investigative Dermatology. 133, S1, p. S145 1 p.854

    Research output: Contribution to journalMeeting abstract

  63. A sweet TET-a-tete-synergy of TET proteins and O-GlcNAc transferase in transcription

    Mariappa, D., Pathak, S. & van Aalten, D. M. F. 2013 In : EMBO Journal. 32, 5, p. 612-613 2 p.

    Research output: Contribution to journalEditorial

  64. Biophysical screening for the discovery of small-molecule ligands

    Ciulli, A. 2013 Protein-ligand interactions: methods and applications. Williams, M. A. & Daviter, T. (eds.). Humana Press, p. 357-388 32 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  65. Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis

    Perry, M. R., Wyllie, S., Raab, A., Feldmann, J. & Fairlamb, A. H. 2013 In : Proceedings of the National Academy of Sciences. n/a, n/a

    Research output: Contribution to journalArticle

  66. Creation and characterization of glycosyltransferase mutants of trypanosoma brucei

    Izquierdo, L., Güther, M. L. S. & Ferguson, M. A. J. 2013 Glycosyltransferases. Brockhausen, I. (ed.). Humana Press, p. 249-275 27 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  67. Discovery and structure-activity relationships of pyrrolone antimalarials

    Murugesan, D., Mital, A., Kaiser, M., Shackleford, D. M., Morizzi, J., Katneni, K., Campbell, M., Hudson, A., Charman, S. A., Yeates, C. & Gilbert, I. H. 2013 In : Journal of Medicinal Chemistry. 56, 7, p. 2975-2990 16 p.

    Research output: Contribution to journalArticle

  68. Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa

    Cukier, C. D., Hope, A. G., Elamin, A. A., Moynie, L., Schnell, R., Schach, S., Kneuper, H., Singh, M., Naismith, J. H., Lindqvist, Y., Gray, D. W. & Schneider, G. 2013 In : ACS Chemical Biology. n/a, cb4005063

    Research output: Contribution to journalArticle

  69. Discovery of Β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

    Aristotelous, T., Ahn, S., Shukla, A. K., Gawron, S., Sassano, M. F., Kahsai, A. W., Wingler, L. M., Zhu, X., Tripathi-Shukla, P., Huang, X-P., Riley, J., Besnard, J., Read, K. D., Roth, B. L., Gilbert, I. H., Hopkins, A. L., Lefkowitz, R. J. & Navratilova, I. 2013 In : ACS Medicinal Chemistry Letters. 4, 10, p. 1005-1010 6 p.

    Research output: Contribution to journalArticle

  70. Drug discovery for neglected diseases: molecular target-based and phenotypic approaches

    Gilbert, I. H. 2013 In : Journal of Medicinal Chemistry. 56, 20, p. 7719-7726 8 p.

    Research output: Contribution to journalArticle

  71. Electromechanical Behaviour of Nafion-based Soft Actuators

    Naji, L., Chudek, J. A., Abel, E. W. & Baker, R. T. 2013 In : Journal of Physical Chemistry B. 1, 19, p. 2502-2514 13 p.

    Research output: Contribution to journalArticle

  72. Imaging African trypanosomes

    MacLean, L., Myburgh, E., Rodgers, J. & Price, H. P. 2013 In : Parasite Immunology. 35, 9-10, p. 283-294 12 p.

    Research output: Contribution to journalArticle

  73. Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes

    Narlikar, G. J., Sundaramoorthy, R. & Owen-Hughes, T. 2013 In : Cell. 154, 3, p. 490-503 14 p.

    Research output: Contribution to journalArticle

  74. Mechanistic dichotomy in the asymmetric allylation of aldehydes with allyltrichlorosilanes catalyzed by chiral pyridine N-oxides

    Malkov, A. V., Stončius, S., Bell, M., Castelluzzo, F., Ramírez-López, P., Biedermannová, L., Langer, V., Rulíšek, L. & Kočovský, P. 2013 In : Chemistry: a European Journal. 19, 28, p. 9167-9185 19 p.

    Research output: Contribution to journalArticle

  75. Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry

    Hahne, H., Sobotzki, N., Nyberg, T., Helm, D., Borodkin, V. S., van Aalten, D. M. F., Agnew, B. & Kuster, B. 2013 In : Journal of Proteome Research. 12, 2, p. 927-936 10 p.

    Research output: Contribution to journalArticle

  76. Regulation of the cardiac Na(+) pump by palmitoylation of its catalytic and regulatory subunits

    Howie, J., Tulloch, L. B., Shattock, M. J. & Fuller, W. 2013 In : Biochemical Society Transactions. 41, 1, p. 95-100 6 p.

    Research output: Contribution to journalArticle

  77. Structure of Pseudomonas aeruginosa inosine 5-monophosphate dehydrogenase

    Rao, V. A., Shepherd, S. M., Owen, R. & Hunter, W. N. 2013 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 3, p. 243-247 5 p.

    Research output: Contribution to journalArticle

  78. Structure-Activity Relationship Studies of Pyrrolone Antimalarial Agents

    Murugesan, D., Kaiser, M., White, K. L., Norval, S., Riley, J., Wyatt, P. G., Charman, S. A., Read, K. D., Yeates, C. & Gilbert, I. H. 2013 In : ChemMedChem.

    Research output: Contribution to journalArticle

  79. The architecture of Trypanosoma brucei tubulin-binding cofactor B and implications for function

    Fleming, J. R., Morgan, R. E., Fyfe, P. K., Kelly, S. M. & Hunter, W. N. 2013 In : FEBS Journal. 280, 14, p. 3270-3280 11 p.

    Research output: Contribution to journalArticle

  80. The CD11b-integrin (ITGAM) and systemic lupus erythematosus

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    Research output: Contribution to journalArticle

  81. The impact of KLF2 modulation on the transcriptional program and function of CD8 T Cells

    Preston, G. C., Feijoo-Carnero, C., Schurch, N., Cowling, V. H. & Cantrell, D. A. 2013 In : PLoS ONE. 8, 10, 16 p.e77537

    Research output: Contribution to journalArticle

  82. The plasticity of a structural motif in RNA: Structural polymorphism of a kink turn as a function of its environment

    Daldrop, P. & Lilley, D. M. J. 2013 In : RNA: a Publication of the RNA Society. 19, 3, p. 357-364 8 p.

    Research output: Contribution to journalArticle

  83. Automated design of ligands to polypharmacological profiles

    Gilbert, I. H. & 20 others Besnard, J., Ruda, G. F., Setola, V., Abecassis, K., Rodriguiz, R. M., Huang, X-P., Norval, S., Sassano, M. F., Shin, A. I., Webster, L. A., Simeons, F. R. C., Stojanovski, L., Prat, A., Seidah, N. G., Constam, D. B., Bickerton, G. R., Read, K. D., Wetsel, W. C., Roth, B. L. & Hopkins, A. L. 13 Dec 2012 In : Nature. 492, 7428, p. 215-+ 8 p.

    Research output: Contribution to journalArticle

  84. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P-3-dependent mechanisms leading to resistance to PDK1 inhibitors

    Najafov, A., Shpiro, N. & Alessi, D. R. Dec 2012 In : Biochemical Journal. 448, 2, p. 285-295 11 p.

    Research output: Contribution to journalArticle

  85. A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes

    De Rycker, M., O'Neill, S., Joshi, D., Campbell, L., Gray, D. W. & Fairlamb, A. H. 29 Nov 2012 In : PLoS Neglected Tropical Diseases. 6, 11, p. e1932

    Research output: Contribution to journalArticle

  86. Structural plasticity of histones H3–H4 facilitates their allosteric exchange between RbAp48 and ASF1

    Zhang, W., Yyl, M., Ward, R., Sobott, F., Maman, J., Murthy, A., Watson, A., Fedorov, O., Bowman, A., Owen-Hughes, T., El Mkami, H., Murzina, N., Norman, D. G. & Laue, E. 25 Nov 2012 In : Nature Structural & Molecular Biology. 20, 1, p. 29-35

    Research output: Contribution to journalArticle

  87. Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α

    Buckley, D. L., Gustafson, J. L., Van-Molle, I., Roth, A. G., Tae, H. S., Gareiss, P. C., Jorgensen, W. L., Ciulli, A. & Crews, C. M. 12 Nov 2012 In : Angewandte Chemie International Edition. 51, 46, p. 11463-11467 5 p.

    Research output: Contribution to journalArticle

  88. Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei

    Alsford, S. & Horn, D. Nov 2012 In : Nucleic Acids Research. 40, 20, p. 10150-10160 11 p.

    Research output: Contribution to journalArticle

  89. Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma

    Pohler, E. , Mamai, O. , Hirst, J. , Zamiri, M. , Horn, H. , Nomura, T. , Irvine, A. D. , Moran, B. , Wilson, N. J. , Smith, F. J. D. , Goh, C. S. M. , Sandilands, A. , Cole, C. , Barton, G. J. , Evans, A. T. , Shimizu, H. , Akiyama, M. , Suehiro, M. , Konohana, I. , Shboul, M. & 12 others Teissier, S., Boussofara, L., Denguezli, M., Saad, A., Gribaa, M., Dopping-Hepenstal, P. J., McGrath, J. A., Brown, S. J., Goudie, D. R., Reversade, B., Munro, C. S. & McLean, W. H. I. Nov 2012 In : Nature Genetics. 44, 11, p. 1272-1276 5 p.

    Research output: Contribution to journalArticle

  90. New secreted toxins and immunity proteins encoded within the type VI secretion system gene cluster of Serratia marcescens

    English, G., Trunk, K., Rao, V. A., Srikannathasan, V., Hunter, W. N. & Coulthurst, S. J. Nov 2012 In : Molecular Microbiology. 86, 4, p. 921-936 16 p.

    Research output: Contribution to journalArticle

  91. Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems

    Nelson, S. A., Li, Z., Newton, I. P., Fraser, D., Milne, R. E., Martin, D. M. A., Schiffmann, D., Yang, X., Dormann, D., Weijer, C. J., Appleton, P. L. & Nathke, I. S. Nov 2012 In : Disease Models & Mechanisms. 5, 6, p. 940-947 8 p.

    Research output: Contribution to journalArticle

  92. Dissecting fragment-based lead discovery at the von hippel-lindau protein: Hypoxia inducible factor 1α protein-protein interface

    Van Molle, I., Thomann, A., Buckley, D. L., So, E. C., Lang, S., Crews, C. M. & Ciulli, A. 26 Oct 2012 In : Chemistry & Biology. 19, 10, p. 1300-1312 13 p.

    Research output: Contribution to journalArticle

  93. Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

    Jones, D. C., Alphey, M. S., Wyllie, S. & Fairlamb, A. H. Oct 2012 In : Molecular Microbiology. 86, 1, p. 51-64 14 p.

    Research output: Contribution to journalArticle

  94. Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121

    Hudson, S. A., McLean, K. J., Surade, S., Yang, Y-Q., Leys, D., Ciulli, A., Munro, A. W. & Abell, C. 10 Sep 2012 In : Angewandte Chemie International Edition. 51, 37, p. 9311-9316 6 p.

    Research output: Contribution to journalArticle

  95. Direct sequencing of Arabidopsis thaliana RNA reveals patterns of cleavage and polyadenylation

    Sherstnev, A., Duc, C., Cole, C., Zacharaki, V., Hornyik, C., Ozsolak, F., Milos, P. M., Barton, G. J. & Simpson, G. G. Aug 2012 In : Nature Structural & Molecular Biology. 19, 8, p. 845-852 8 p.

    Research output: Contribution to journalArticle

  96. Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

    Baker, N., Glover, L., Munday, J. C., Andres, D. A., Barrett, M. P., de Koning, H. P. & Horn, D. 3 Jul 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 27, p. 10996-11001 6 p.

    Research output: Contribution to journalArticle

  97. Essential Role for IKK beta in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

    Pauls, E., Shpiro, N., Peggie, M., Young, E. R., Sorcek, R. J., Tan, L., Choi, H. G. & Cohen, P. 1 Jun 2012 In : Journal of Biological Chemistry. 287, 23, p. 19216-19228 13 p.

    Research output: Contribution to journalArticle

  98. Pathways analysis in kidney cancer using proteomics approach

    Zakikhani, M., Atrih, A., Lamont, S. R., Goodman, C., Fleming, I. N. & Nabi, G. Jun 2012 In : BJU International. 109, p. 24-24 1 p.

    Research output: Contribution to journalSpecial issue

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