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  1. Global Quantitative SILAC Phosphoproteomics Reveals Differential Phosphorylation Is Widespread between the Procyclic and Bloodstream Form Lifecycle Stages of Trypanosoma brucei

    Urbaniak, M. D., Martin, D. M. A. & Ferguson, M. A. J. 3-May-2013 In : Journal of Proteome Research. 12, 5, p. 2233-2244, 12 p.

    Research output: Contribution to journalArticle

  2. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

    Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P. 1-May-2013 In : Biochemical Journal. 451, 3, p. 427-437, 11 p.

    Research output: Contribution to journalArticle

  3. Improved sperm function / activity

    Barratt, C. & Wyatt, P. 18-Apr-2013 WO2013054111 A1

    Research output: Patent

  4. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

    Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3-Apr-2013 In : EMBO Journal. 32, 7, p. 1008-22, 15 p.

    Research output: Contribution to journalArticle

  5. The architecture of EssB, an integral membrane component of the type VII secretion system

    Zoltner, M., Norman, D. G., Fyfe, P. K., El Mkami, H., Palmer, T. & Hunter, W. N. 2-Apr-2013 In : Structure. 21, 4, p. 595-603, 9 p.

    Research output: Contribution to journalArticle

  6. The importance of the N-terminus of T7 endonuclease I in the interaction with DNA junctions

    Freeman, A. D. J., Déclais, A-C. & Lilley, D. M. J. 23-Jan-2013 In : Journal of Molecular Biology. 425, 2, p. 395-410, 16 p.

    Research output: Contribution to journalArticle

  7. Characterization of Staphylococcus aureus EssB, an integral membrane component of the Type VII secretion system: atomic resolution crystal structure of the cytoplasmic segment

    Zoltner, M., Fyfe, P. K., Palmer, T. & Hunter, W. N. 15-Jan-2013 In : Biochemical Journal. 449, 2, p. 469-477, 9 p.

    Research output: Contribution to journalArticle

  8. PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway

    Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15-Jan-2013 In : Journal of Immunology. 190, 2, p. 565-77, 13 p.

    Research output: Contribution to journalArticle

  9. A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle

    Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., Shattock, M. J., Calaghan, S. C. & Fuller, W. 2013 In : Journal of Biological Chemistry.

    Research output: Contribution to journalArticle

  10. A sweet TET-a-tete-synergy of TET proteins and O-GlcNAc transferase in transcription

    Mariappa, D., Pathak, S. & van Aalten, D. M. F. 2013 In : EMBO Journal. 32, 5, p. 612-613, 2 p.

    Research output: Contribution to journalEditorial

  11. Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.

    De Rycker, M., Hallyburton, I., Thomas, J., Campbell, L., Wyllie, S., Joshi, D., Cameron, S., Gilbert, I. H., Wyatt, P. G., Frearson, J. A., Fairlamb, A. H. & Gray, D. W. 2013 In : Antimicrobial Agents and Chemotherapy.

    Research output: Contribution to journalArticle

  12. Electromechanical Behaviour of Nafion-based Soft Actuators

    Naji, L., Chudek, J. A., Abel, E. W. & Baker, R. T. 2013 In : Journal of Physical Chemistry B. 1, 19, p. 2502-2514, 13 p.

    Research output: Contribution to journalArticle

  13. Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry

    Hahne, H., Sobotzki, N., Nyberg, T., Helm, D., Borodkin, V. S., van Aalten, D. M. F., Agnew, B. & Kuster, B. 2013 In : Journal of Proteome Research. 12, 2, p. 927-936, 10 p.

    Research output: Contribution to journalArticle

  14. Regulation of the cardiac Na(+) pump by palmitoylation of its catalytic and regulatory subunits

    Howie, J., Tulloch, L. B., Shattock, M. J. & Fuller, W. 2013 In : Biochemical Society Transactions. 41, 1, p. 95-100, 6 p.

    Research output: Contribution to journalArticle

  15. Structure of Pseudomonas aeruginosa inosine 5-monophosphate dehydrogenase

    Rao, V. A., Shepherd, S. M., Owen, R. & Hunter, W. N. 2013 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 3, p. 243-247, 5 p.

    Research output: Contribution to journalArticle

  16. The plasticity of a structural motif in RNA: Structural polymorphism of a kink turn as a function of its environment

    Daldrop, P. & Lilley, D. M. J. 2013 In : RNA: a Publication of the RNA Society. 19, 3, p. 357-364, 8 p.

    Research output: Contribution to journalArticle

  17. Automated design of ligands to polypharmacological profiles

    Gilbert, I. H. & 20 others Besnard, J., Ruda, G. F., Setola, V., Abecassis, K., Rodriguiz, R. M., Huang, X-P., Norval, S., Sassano, M. F., Shin, A. I., Webster, L. A., Simeons, F. R. C., Stojanovski, L., Prat, A., Seidah, N. G., Constam, D. B., Bickerton, G. R., Read, K. D., Wetsel, W. C., Roth, B. L. & Hopkins, A. L. 13-Dec-2012 In : Nature. 492, 7428, p. 215-+, 8 p.

    Research output: Contribution to journalArticle

  18. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P-3-dependent mechanisms leading to resistance to PDK1 inhibitors

    Najafov, A., Shpiro, N. & Alessi, D. R. Dec-2012 In : Biochemical Journal. 448, 2, p. 285-295, 11 p.

    Research output: Contribution to journalArticle

  19. A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes

    De Rycker, M., O'Neill, S., Joshi, D., Campbell, L., Gray, D. W. & Fairlamb, A. H. 29-Nov-2012 In : PLoS Neglected Tropical Diseases. 6, 11, p. e1932

    Research output: Contribution to journalArticle

  20. Structural plasticity of histones H3–H4 facilitates their allosteric exchange between RbAp48 and ASF1

    Zhang, W., Yyl, M., Ward, R., Sobott, F., Maman, J., Murthy, A., Watson, A., Fedorov, O., Bowman, A., Owen-Hughes, T., El Mkami, H., Murzina, N., Norman, D. G. & Laue, E. 25-Nov-2012 In : Nature Structural & Molecular Biology. 20, 1, p. 29-35

    Research output: Contribution to journalArticle

  21. Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α

    Buckley, D. L., Gustafson, J. L., Van-Molle, I., Roth, A. G., Tae, H. S., Gareiss, P. C., Jorgensen, W. L., Ciulli, A. & Crews, C. M. 12-Nov-2012 In : Angewandte Chemie International Edition. 51, 46, p. 11463-11467, 5 p.

    Research output: Contribution to journalArticle

  22. Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei

    Urbaniak, M. D., Mathieson, T., Bantscheff, M., Eberhard, D., Grimaldi, R., Miranda-Saavedra, D., Wyatt, P., Ferguson, M. A. J., Frearson, J. & Drewes, G. Nov-2012 In : ACS Chemical Biology. 7, 11, p. 1858-1865, 8 p.

    Research output: Contribution to journalArticle

  23. Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma

    Pohler, E. , Mamai, O. , Hirst, J. , Zamiri, M. , Horn, H. , Nomura, T. , Irvine, A. D. , Moran, B. , Wilson, N. J. , Smith, F. J. D. , Goh, C. S. M. , Sandilands, A. , Cole, C. , Barton, G. J. , Evans, A. T. , Shimizu, H. , Akiyama, M. , Suehiro, M. , Konohana, I. , Shboul, M. & 12 others Teissier, S., Boussofara, L., Denguezli, M., Saad, A., Gribaa, M., Dopping-Hepenstal, P. J., McGrath, J. A., Brown, S. J., Goudie, D. R., Reversade, B., Munro, C. S. & McLean, W. H. I. Nov-2012 In : Nature Genetics. 44, 11, p. 1272-1276, 5 p.

    Research output: Contribution to journalArticle

  24. New secreted toxins and immunity proteins encoded within the type VI secretion system gene cluster of Serratia marcescens

    English, G., Trunk, K., Rao, V. A., Srikannathasan, V., Hunter, W. N. & Coulthurst, S. J. Nov-2012 In : Molecular Microbiology. 86, 4, p. 921-936, 16 p.

    Research output: Contribution to journalArticle

  25. Dissecting fragment-based lead discovery at the von hippel-lindau protein: Hypoxia inducible factor 1α protein-protein interface

    Van Molle, I., Thomann, A., Buckley, D. L., So, E. C., Lang, S., Crews, C. M. & Ciulli, A. 26-Oct-2012 In : Chemistry & Biology. 19, 10, p. 1300-1312, 13 p.

    Research output: Contribution to journalArticle

  26. Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

    Jones, D. C., Alphey, M. S., Wyllie, S. & Fairlamb, A. H. Oct-2012 In : Molecular Microbiology. 86, 1, p. 51-64, 14 p.

    Research output: Contribution to journalArticle

  27. Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121

    Hudson, S. A., McLean, K. J., Surade, S., Yang, Y-Q., Leys, D., Ciulli, A., Munro, A. W. & Abell, C. 10-Sep-2012 In : Angewandte Chemie International Edition. 51, 37, p. 9311-9316, 6 p.

    Research output: Contribution to journalArticle

  28. Transcriptome analysis of atopic skin demonstrates the importance of extracellular mechanisms in the filaggrin-related barrier defect

    Brown, S., Cole, C., McLean, I., Barton, G. & Irvine, A. Sep-2012 In : Journal of Investigative Dermatology. 132, p. S94-S94, 1 p.

    Research output: Contribution to journalMeeting abstract

  29. Essential Role for IKK beta in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

    Pauls, E., Shpiro, N., Peggie, M., Young, E. R., Sorcek, R. J., Tan, L., Choi, H. G. & Cohen, P. 1-Jun-2012 In : Journal of Biological Chemistry. 287, 23, p. 19216-19228, 13 p.

    Research output: Contribution to journalArticle

  30. Pathways analysis in kidney cancer using proteomics approach

    Zakikhani, M., Atrih, A., Lamont, S. R., Goodman, C., Fleming, I. N. & Nabi, G. Jun-2012 In : BJU International. 109, p. 24-24, 1 p.

    Research output: Contribution to journalSpecial issue

  31. Structure and folding of a rare, natural kink turn in RNA with an A•A pair at the 2•d2n position

    Schroeder, K. T., Daldrop, P., McPhee, S. A. & Lilley, D. M. J. Jun-2012 In : RNA: a Publication of the RNA Society. 18, 6, p. 1257-1266, 10 p.

    Research output: Contribution to journalArticle

  32. Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation

    Klotz-Noack, K., McIntosh, D., Schurch, N., Pratt, N. & Blow, J. J. 15-May-2012 In : Journal of Cell Science. 125, 10, p. 2436-2445, 10 p.

    Research output: Contribution to journalArticle

  33. Combining PET biodistribution and equilibrium dialysis assays to assess the free brain concentration and BBB transport of CNS drugs

    Gunn, R. N., Summerfield, S. G., Salinas, C. A., Read, K. D., Guo, Q., Searle, G. E., Parker, C. A., Jeffrey, P. & Laruelle, M. May-2012 In : Journal of Cerebral Blood Flow and Metabolism. 32, 5, p. 874-883, 10 p.

    Research output: Contribution to journalArticle

  34. Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo

    Hack, K., Reilly, L., Palmer, C., Read, K., Norval, S., Kime, R., Booth, K. & Foerster, J. May-2012 In : PLoS ONE. 7, 5

    Research output: Contribution to journalArticle

  35. The lipid-linked oligosaccharide donor specificities of Trypanosoma brucei oligosaccharyltransferases

    Izquierdo, L., Mehlert, A. & Ferguson, M. A. J. May-2012 In : Glycobiology. 22, 5, p. 696-703, 8 p.

    Research output: Contribution to journalArticle

  36. Guidelines for the use and interpretation of assays for monitoring autophagy

    Klionsky, D. J. , Backues, S. K. , Bartholomew, C. R. , Bridges, D. , Gestwicki, J. E. , Han, T. , Jin, M. , Kim, J. K. , Lin, J. D. , Lynch-Day, M. A. , Mao, K. , Nair, U. , Parzych, K. R. , Umekawa, M. , Wang, K. , Yen, W-L. , Zhao, M. , Olsen, L. J. , Abdalla, F. C. , Marcondes, M. & 1,235 others Silva-Zacarin, E. C. M., Silva-Zacarin, E., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Chiarelli, R., Roccheri, M. C., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., Ait-Si-Ali, S., Akematsu, T., Akira, S., Saitoh, T., Al-Younes, H. M., Al-Zeer, M. A., Meyer, T. F., Albert, M. L., Albin, R. L., Dowling, J. J., Alegre-Abarrategui, J., Wade-Martins, R., Aleo, M. F., Fanzani, A., Rovetta, F., Alirezaei, M., Chisari, F. V., Whitton, J. L., Almasan, A., Almonte-Becerril, M., Kouri Flores, J. B., Amano, A., Amaravadi, R., Amarnath, S., Fowler, D. H., Amer, A. O., Drew, M. E., Andrieu-Abadie, N., Poirot, M., Vindis, C., Anantharam, V., Kanthasamy, A. G., Kanthasamy, A., Ann, D. K., Anoopkumar-Dukie, S., Grant, G. D., Aoki, H., Apostolova, N., Arancia, G., Condello, M., Meschini, S., Aris, J. P., Asanuma, K., Tomino, Y., Asare, N. Y. O., Ashida, H., Askanas, V., Nogalska, A., Askew, D. S., Auberger, P., Bost, F., Gual, P., Luciano, F., Rocchi, S., Baba, M., Baehrecke, E. H., Bahr, B. A., Bai, X-Y., Chen, X., Bailly, Y., Baiocchi, R., Baldini, G., Balduini, W., Ballabio, A., Brunetti-Pierri, N., Settembre, C., Bamber, B. A., Bampton, E. T. W., Melino, G., Bánhegyi, G., Bassham, D. C., Bast Jr., R. C., Fan, Z., Lopez-Berestein, G., Lu, Z., Ozpolat, B., Batoko, H., Bay, B-H., Beau, I., Esclatine, A., Béchet, D. M., Begley, T. J., Behl, C., Behrends, C., Dikic, I., Bekri, S., Bellaire, B., Bendall, L. J., Benetti, L., Berliocchi, L., Bernardi, H., Sanchez, A. M. J., Bernassola, F., Marfe, G., Palumbo, C., Besteiro, S., Bhatia-Kissova, I., Bi, X., Biard-Piechaczyk, M., Espert, L., Blum, J. S., Boise, L. H., Lonial, S., Sun, S-Y., Bonaldo, P., Sandri, M., Boone, D. L., Bornhauser, B. C., Bourquin, J-P., Bortoluci, K. R., Bossis, I., Boya, P., Boyer-Guittaut, M., Bozhkov, P. V., Brady, N. R., Brancolini, C., Brech, A., Nezis, I. P., Rusten, T. E., Stenmark, H., Brenman, J. E., Brennand, A., Michels, P. A. M., Bresnick, E. H., Kang, Y-A., Brest, P., Hofman, P., Mograbi, B., Bristol, M. L., Gewirtz, D. A., Brookes, P. S., Johnson, G. V. W., Brown, E. J., Brumell, J. H., Huang, J., Kim, P. K., Brunk, U. T., Kurz, T., Bulman, D. E., Bultman, S. J., Bultynck, G., Parys, J. B., Burbulla, L. F., Krüger, R., Bursch, W., Butchar, J. P., Buzgariu, W., Galliot, B., Bydlowski, S. P., Cadwell, K., Cahová, M., Papackova, Z., Cai, D., Cai, J., Cai, Q., Calabretta, B., Sotgia, F., Calvo-Garrido, J., Escalante, R., Camougrand, N., Manon, S., Priault, M., Campanella, M., Campos-Salinas, J., Gonzalez-Rey, E., Oliver, F. J., Candi, E., Cao, L., Caplan, A. B., Carding, S. R., Cardoso, S. M., Moreira, P. I., Carew, J. S., Nawrocki, S. T., Carlin, C. R., Carmignac, V., Durbeej, M., Carneiro, L. A. M., Carra, S., Kampinga, H. H., Caruso, R. A., Casari, G., Casas, C., Castino, R., Isidoro, C., Cebollero, E., Reggiori, F., Cecconi, F., Ciriolo, M. R., Piacentini, M., Celli, J., Chaachouay, H., Rodemann, H. P., Chae, H-J., Chai, C-Y., Chan, D. C., Chan, E. Y., Coombs, G. H., Chang, R. C-C., Che, C-M., Lok, C-N., Sy, L-K., Chen, C-C., Lin, W-W., Chen, G-C., Yang, W. Y., Chen, G-Q., Chen, M., Wang, J., Chen, Q., Chen, S. S-L., Ke, P-Y., Lin, Y-L., Chen, W., Chen, Y-G., Liu, Y., Yu, L., Chen, Y., Guan, J-L., Towns, R., Wiley, J. W., Chen, Y-J., Chen, Z., Cheng, A., Cheng, C. H. K., Cheng, Y., Wang, H-G., Yang, J-M., El-Deiry, W. S., Cheong, H., Thompson, C. B., Cheong, J-H., Cherry, S., Chess-Williams, R., Cheung, Z. H., Chevet, E., Chiang, H-L., Chiba, T., Chin, L-S., Li, L., Mao, Z., Chiou, S-H., Cho, C. H., Cho, D-H., Choi, A. M. K., Haspel, J. A., Henske, E. P., Nakahira, K., Ryter, S. W., Choi, D., Choi, K. S., Choi, M. E., Münger, K., Chouaib, S., Choubey, D., Choubey, V., Kaasik, A., Chu, C. T., Rabinowich, H., Chuang, T-H., Chueh, S-H., Chun, T., Park, O. K., Chwae, Y-J., Chye, M-L., Ciarcia, R., Florio, S., Granato, G. E., Clague, M. J., Clark, R. S. B., Clarke, P. G. H., Puyal, J., Clarke, R., Saha, T., Codogno, P., Coller, H. A., Colombo, M. I., Comincini, S., Condorelli, F., Cookson, M. R., Coppens, I., Corbalan, R., Cossart, P., Costelli, P., Costes, S., Coto-Montes, A., Couve, E., Coxon, F. P., Helfrich, M. H., Hocking, L. J., Cregg, J. M., Crespo, J. L., Cronjé, M. J., Cuervo, A. M., Kaushik, S., Koga, H., Czaja, M. J., Cullen, J. J., D'Amelio, M., Darfeuille-Michaud, A., Davids, L. M., Davies, F. E., De Felici, M., De Groot, J. F., Fueyo, J., Gomez-Manzano, C., Jiang, H., De Haan, C. A. M., Monastyrska, I., De Martino, L., Fiorito, F., Iovane, V., Pagnini, U., De Milito, A., Joseph, B., Panaretakis, T., De Tata, V., Debnath, J., Degterev, A., Dehay, B., Delbridge, L. M. D., Demarchi, F., Schneider, C., Deng, Y. Z., Naqvi, N. I., Dengjel, J., Dent, P., Denton, D., Kumar, S., Deretic, V., Desai, S. D., Devenish, R. J., Mijaljica, D., Prescott, M., Ramm, G., Di Gioacchino, M., Di Paolo, G., Duff, K., Yu, W. H., Przedborski, S., Yamamoto, A., Di Pietro, C., Marazziti, D., Matteoni, R., Tocchini-Valentini, G., Díaz-Araya, G., Díaz-Laviada, I., Diaz-Meco, M. T., Fotedar, R., Hansen, M., Moscat, J., Reed, J. C., Salvesen, G., Yang, Z., Diaz-Nido, J., Izquierdo, M., Dinesh-Kumar, S. P., Ding, W-X., Distelhorst, C. W., Subauste, C. S., Wang, X., Zhu, X., Oleinick, N. L., Diwan, A., Djavaheri-Mergny, M., Dokudovskaya, S., Dong, Z., Willbold, D., Dorsey, F. C., Dosenko, V., Doxsey, S., Dreux, M., Duan, Q., Duchosal, M. A., Dugail, I., Kroemer, G., Maiuri, M. C., Duszenko, M., Edelstein, C. L., Edinger, A. L., Egea, G., Eichinger, L., Noegel, A. A., Eissa, N. T., Lin, W-C., Ekmekcioglu, S., Elazar, Z., Elgendy, M., Minucci, S., Ellerby, L. M., Er Eng, K., McInerney, G. M., Engelbrecht, A-M., Loos, B., Engelender, S., Erenpreisa, J., Eskelinen, E-L., Espina, V., Fan, H., Fan, J., Fan, Q-W., Ilkhanizadeh, S., Weiss, W. A., Fang, S., Monteiro, M. J., Fang, Y., Fanto, M., Farkas, T., Jäättelä, M., Farré, J-C., Nazarko, T. Y., Faure, M., Fechheimer, M., Furukawa, R. H., Feng, C. G., Feng, J., Feng, Q., Feng, Y., Fésüs, L., Feuer, R., Figueiredo-Pereira, M. E., Fimia, G. M., Fingar, D. C., Finkbeiner, S., Finkel, T., Finley, K. D., Gottlieb, R. A., Fisher, E. A., Fisher, P. B., Flajolet, M., Tian, Y., Florez-McClure, M. L., Fon, E. A., Fornai, F., Fortunato, F., Fox, H. S., Franco, R., Frankel, L. B., Lund, A. H., Fransen, M., Fuentes, J. M., González-Polo, R. A., Fujii, J., Fujisaki, K., Umemiya-Shirafuji, R., Fujita, E., Fukuda, M., Gaestel, M., Menon, M. B., Gailly, P., Gajewska, M., Motyl, T., Galy, V., Ganesh, S., Ganetzky, B., Ganley, I. G., Gao, F-B., Gao, G. F., Gao, J., Garcia, L., Lavandero, S., Garcia-Manero, G., Garcia-Marcos, M., Garmyn, M., Gartel, A. L., Gatti, E., Golstein, P., Pierre, P., Gautel, M., Gawriluk, T. R., Hale, A. N., Ledbetter, D. J., Rucker III, E. B., Gegg, M. E., Schapira, A. H. V., Geng, J., Harper, J. W., Germain, M., Slack, R. S., Lieberman, A., Lukacs, N. W., Ghavami, S., Halayko, A. J., Kirshenbaum, L. A., Yeganeh, B., Ghosh, P., Lee, J., Giammarioli, A. M., Malorni, W., Giatromanolaki, A. N., Sivridis, E., Gibson, S. B., Gilkerson, R. W., Sulzer, D., Ginger, M. L., Ginsberg, H. N., Tabas, I., Golab, J., Goligorsky, M. S., Goncu, E., Gongora, C., Le Cam, L., Pattingre, S., Gonzalez, C. D., Vaccaro, M. I., Gonzalez, R., González-Estévez, C., Gorbunov, N. V., Gorski, S., Goruppi, S., Gozuacik, D., Green, K. N., Gregorc, A., Gros, F., Muller, S., Grose, C., Grunt, T. W., Guan, K-L., Guichard, S. M., Gukovskaya, A. S., Gukovsky, I., Gunst, J., Van Den Berghe, G., Vanhorebeek, I., Gustafsson, A. B., Halonen, S. K., Hamasaki, M., Noda, T., Yoshimori, T., Han, F., Hancock, M. K., Harada, H., Harada, M., Hardt, S. E., Harris, A. L., Harris, J., Harris, S. D., Hashimoto, M., Hayashi, S-I., Hazelhurst, L. A., He, C., Levine, B., Terada, A. S., He, Y-W., Rathmell, J. C., Taylor, G. A., Hébert, M-J., Heidenreich, K. A., Helgason, G. V., Holyoake, T. L., Herman, B., Reiter, R. J., Herman, P. K., Hetz, C., Hilfiker, S., Navarro, M., Hill, J. A., Nemchenko, A., Yoshimoto, K., Hofmann, T. G., Höhfeld, J., Hong, M-H., Hood, D. A., Hotamisligil, G. S., Houwerzijl, E. J., Høyer-Hansen, M., Hu, B., Hu, C-A. 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  38. Modeling of the N-Glycosylated Transferrin Receptor Suggests How Transferrin Binding Can Occur within the Surface Coat of Trypanosoma brucei

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  40. The de novo and salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-form Trypanosoma brucei

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  43. A quantitative spatial proteomics analysis of proteome turnover in human cells

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  44. Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness

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  47. Comparative proteomics profiling of a gentamicin-attenuated Leishmania infantum cell line identifies key changes in parasite thiol-redox metabolism

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  48. Identification and localisation of the NB-LRR gene family within the potato genome

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  49. Quinol derivatives as potential trypanocidal agents

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  51. Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

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  52. The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis

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  55. The crystal structure of Leishmania major N-5,N-10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target

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  56. Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

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  57. The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces

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  58. Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

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  59. A comparative study of the CYP450 inhibition potential of marketed drugs using two fluorescence based assay platforms routinely used in the pharmaceutical industry

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  60. Allosteric Competitive Inhibitors of the Glucose-1-phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa

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  61. Assessment of pseudomonas aeruginosa N-5,N-10-methylenetetrahydrofolate dehydrogenase - cyclohydrolase as a potential antibacterial drug target

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  62. Avirulence protein 3a (AVR3a) from the potato pathogen Phytophthora infestans forms homodimers through its predicted translocation region and does not specifically bind phospholipids

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  63. BioJava: an open-source framework for bioinformatics in 2012

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  64. Change or be changed: reflections of the workshop 'Future in Medicinal Chemistry'

    Brenk, R. & Rauh, D. 2012 In : Bioorganic & Medicinal Chemistry. 20, 12, p. 3695-3697, 3 p.

    Research output: Contribution to journalArticle

  65. Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo

    Wishart, T. M., Rooney, T. M., Lamont, D. J., Wright, A. K., Morton, A. J., Jackson, M., Freeman, M. R. & Gillingwater, T. H. 2012 In : PLoS Genetics. 8, 8

    Research output: Contribution to journalArticle

  66. Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages

    Urbaniak, M. D., Guther, M. L. S. & Ferguson, M. A. J. 2012 In : PLoS ONE. 7, 5, p. -, 8 p., e36619

    Research output: Contribution to journalArticle

  67. Direct sequencing of Arabidopsis thaliana RNA reveals patterns of cleavage and polyadenylation

    Sherstnev, A., Duc, C., Cole, C., Zacharaki, V., Hornyik, C., Ozsolak, F., Milos, P. M., Barton, G. J. & Simpson, G. G. 2012 In : Nature Structural & Molecular Biology.

    Research output: Contribution to journalArticle

  68. Genetic diversity in European Pisum germplasm collections

    Jing, R., Ambrose, M. A., Knox, M. R., Smykal, P., Hybl, M., Ramos, A., Caminero, C., Burstin, J., Duc, G., van Soest, L. J. M., Swiecicki, W. K., Pereira, M. G., Vishnyakova, M., Davenport, G. F., Flavell, A. J. & Ellis, T. H. N. 2012 In : Theoretical and Applied Genetics. 125, 2, p. 367-380, 14 p.

    Research output: Contribution to journalArticle

  69. Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide- binding properties

    Schimpl, M., Rush, C. L., Betou, M., Eggleston, I. M., Recklies, A. D. & van Aalten, D. M. F. 2012 In : Biochemical Journal. 446, 1, p. 149-157, 9 p.

    Research output: Contribution to journalArticle

  70. IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening

    Tidten-Luksch, N., Grimaldi, R., Torrie, L. S., Frearson, J. A., Hunter, W. N. & Brenk, R. 2012 In : PLoS ONE. 7, 4, p. -, 16 p., e35792

    Research output: Contribution to journalArticle

  71. Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation

    Fyfe, P. K., Westrop, G. D., Silva, A. M., Coombs, G. H. & Hunter, W. N. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 29, p. 11693-11698, 6 p.

    Research output: Contribution to journalArticle

  72. Live imaging of nascent RNA dynamics reveals distinct types of transcriptional pulse regulation

    Muramoto, T., Cannon, D., Gierlinski, M., Corrigan, A., Barton, G. J. & Chubb, J. R. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 19, p. 7350-7355, 6 p.

    Research output: Contribution to journalArticle

  73. MSK1 regulates homeostatic and experience-dependent synaptic plasticity

    Corrêa, S. A. L., Hunter, C. J., Palygin, O., Wauters, S. C., Martin, K. J., McKenzie, C., McKelvey, K., Morris, R. G. M., Pankratov, Y., Arthur, J. S. C. & Frenguelli, B. 2012 In : Journal of Neuroscience. 32, 38, p. 13039-13051, 13 p.

    Research output: Contribution to journalArticle

  74. O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

    Schimpl, M., Zheng, X., Borodkin, V. S., Blair, D. E., Ferenbach, A. T., Schüttelkopf, A. W., Navratilova, I., Aristotelous, T., Albarbarawi, O., Robinson, D. A., van Aalten, D. M. F. & Macnaughtan, M. A. 2012 In : Nature Chemical Biology.

    Research output: Contribution to journalArticle

  75. Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase

    Bandini, G., Marino, K., Güther, M. L. S., Wernimont, A. K., Kuettel, S., Qiu, W., Afzal, S., Kelner, A., Hui, R. & Ferguson, M. A. J. 2012 In : Molecular Microbiology. 85, 3, p. 513-534, 22 p.

    Research output: Contribution to journalArticle

  76. PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

    Tibarewal, P., Zilidis, G., Spinelli, L., Schurch, N., Maccario, H., Gray, A., Perera, N. M., Davidson, L., Barton, G. J. & Leslie, N. R. 2012 In : Science Signaling. 5, 213, p. ra18

    Research output: Contribution to journalArticle

  77. Structural and biochemical characterization of a trapped coenzyme a adduct of Caenorhabditis elegans glucosamine-6-phosphate N-acetyltransferase 1

    Dorfmueller, H. C., Fang, W., Rao, F. V., Blair, D. E., Attrill, H. & van Aalten, D. M. F. 2012 In : Acta Crystallographica Section D: Biological Crystallography. 68, 8, p. 1019-1029, 11 p.

    Research output: Contribution to journalArticle

  78. Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

    Cui, H., Carrero-Lérida, J., Silva, A. P. G., Whittingham, J. L., Brannigan, J. A., Ruiz-Pérez, L. M., Read, K. D., Wilson, K. S., González-Pacanowska, D. & Gilbert, I. H. 2012 In : Journal of Medicinal Chemistry. 55, 24, p. 10948-57, 10 p.

    Research output: Contribution to journalArticle

  79. Synthesis of novel tetrazole C5-linked C0- and C2-ribonucleoside phosphoramidites using MePOM and POM groups for probing RNA catalysis

    Harusawa, S., Yoneyama, H., Fujisue, D., Nishiura, M., Fujitake, M., Usami, Y., Zhao, Z., Mcphee, S. A., Wilson, T. J. & Lilley, D. M. J. 2012 In : Tetrahedron Letters. 53, 44, p. 5891-5894, 4 p.

    Research output: Contribution to journalArticle

  80. The kinomes of apicomplexan parasites

    Miranda-Saavedra, D., Gabaldón, T., Barton, G. J., Langsley, G. & Doerig, C. 2012 In : Microbes and Infection. 14, 10, p. 796-810, 15 p.

    Research output: Contribution to journalArticle

  81. The structure and folding of helical junctions in RNA

    Lilley, D. M. J. 2012 Innovations in Biomolecular Modeling and Simulations. Schlick, T. (ed.). Cambridge: Royal Society of Chemistry, (RSC Biomolecular Sciences).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  82. The structure and folding of kink turns in RNA

    Lilley, D. M. J. 2012 In : Wiley Interdisciplinary Reviews: RNA. 3, 6, p. 797-805, 9 p.

    Research output: Contribution to journalArticle

  83. Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems

    Nelson, S. A., Li, Z., Newton, I. P., Fraser, D., Milne, R. E., Martin, D. M. A., Schiffmann, D., Yang, X., Dormann, D., Weijer, C. J., Appleton, P. L. & Nathke, I. S. 2012 In : Disease Models & Mechanisms.

    Research output: Contribution to journalArticle

  84. Whole organism high-content screening by label-free, image-based bayesian classification for parasitic diseases

    Paveley, R. A., Mansour, N. R., Hallyburton, I., Bleicher, L. S., Benn, A. E., Mikic, I., Guidi, A., Gilbert, I. H., Hopkins, A. L. & Bickle, Q. D. 2012 In : PLoS Neglected Tropical Diseases. 6, 7, e1762

    Research output: Contribution to journalArticle

  85. Investigation of copper(II) tetrafluoroborate catalysed epoxide opening

    Capes, A. S., Crossman, A. T., Webster, L. A., Ferguson, M. A. J. & Gilbert, I. H. 28-Dec-2011 In : Tetrahedron Letters. 52, 52, p. 7091-7094, 4 p.

    Research output: Contribution to journalArticle

  86. Protein O-GlcNAcylation is required for fibroblast growth factor signaling in Drosophila

    Mariappa, D., Sauert, K., Marino, K., Turnock, D., Webster, R., van Aalten, D. M. F., Ferguson, M. A. J. & Muller, H. A. J. 20-Dec-2011 In : Science Signaling. 4, 204, p. -, 8 p., ra89

    Research output: Contribution to journalArticle

  87. Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

    Cleghorn, L. A. T., Woodland, A., Collie, I. T., Torrie, L. S., Norcross, N., Luksch, T., Mpamhanga, C., Walker, R. G., Mottram, J. C., Brenk, R., Frearson, J. A., Gilbert, I. H. & Wyatt, P. G. 9-Dec-2011 In : ChemMedChem. 6, 12, p. 2214-2224, 11 p.

    Research output: Contribution to journalArticle

  88. Syringyl lignin is unaltered by severe sinapyl alcohol dehydrogenase suppression in tobacco

    Barakate, A., Stephens, J., Goldie, A., Hunter, W. N., Marshall, D., Hancock, R. D., Lapierre, C., Morreele, K., Boerjane, W. & Halpin, C. Dec-2011 In : Plant Cell. 23, 12, p. 4492-4506, 15 p.

    Research output: Contribution to journalArticle

  89. The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system

    Rao, V. A., Shepherd, S. M., English, G., Coulthurst, S. J. & Hunter, W. N. Dec-2011 In : Acta Crystallographica Section D: Biological Crystallography. 67, p. 1065-1072, 8 p.

    Research output: Contribution to journalArticle

  90. Chemical structure of Trichomonas vaginalis surface lipoglycan: a role for short galactose (beta 1-4/3) N-acetylglucosamine repeats in host cell interaction

    Ryan, C. M., Mehlert, A., Richardson, J. M., Ferguson, M. A. J. & Johnson, P. J. 25-Nov-2011 In : Journal of Biological Chemistry. 286, 47, p. 40494-40508, 15 p.

    Research output: Contribution to journalArticle

  91. From snoRNA to miRNA: Dual function regulatory non-coding RNAs

    Scott, M. S. & Ono, M. 1-Nov-2011 In : Biochimie. 93, 11, p. 1987-1992, 6 p.

    Research output: Contribution to journalArticle

  92. DrugPred: A Structure-Based Approach To Predict Protein Druggability Developed Using an Extensive Nonredundant Data Set

    Krasowski, A., Muthas, D., Sarkar, A., Schmitt, S. & Brenk, R. Nov-2011 In : Journal of Chemical Information and Modeling. 51, 11, p. 2829-2842, 14 p.

    Research output: Contribution to journalArticle

  93. Cell migration modulating compounds

    Schor, A. M., Schor, S. L., Marquez, R. & Norman, D. G. 19-Oct-2011 EP1917012

    Research output: Patent

  94. Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

    Patterson, S., Alphey, M. S., Jones, D. C., Shanks, E. J., Street, I. P., Frearson, J. A., Wyatt, P. G., Gilbert, I. H. & Fairlamb, A. H. 13-Oct-2011 In : Journal of Medicinal Chemistry. 54, 19, p. 6514-6530, 17 p.

    Research output: Contribution to journalArticle

  95. Design, Synthesis, and Evaluation of 5 '-Diphenyl Nucleoside Analogues as Inhibitors of the Plasmodium falciparum dUTPase

    Hampton, S. E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Alexander Musso-Buendia, J., Recio, E., Kaiser, M., Whittingham, J. L., Roberts, S. M., Shevtsov, M., Brannigan, J. A., Kahnberg, P., Brun, R., Wilson, K. S., Gonzalez-Pacanowska, D., Johansson, N. G. & Gilbert, I. H. 4-Oct-2011 In : ChemMedChem. 6, 10, p. 1816-1831, 16 p.

    Research output: Contribution to journalArticle

  96. Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

    Smith, V. C., Cleghorn, L. A. T., Woodland, A., Spinks, D., Hallyburton, I., Collie, I. T., Mok, N. Y., Norval, S., Brenk, R., Fairlamb, A. H., Frearson, J. A., Read, K. D., Gilbert, I. H. & Wyatt, P. G. 4-Oct-2011 In : ChemMedChem. 6, 10, p. 1832-1840, 9 p.

    Research output: Contribution to journalArticle

  97. Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery

    Philpott, M., Yang, J., Tumber, T., Fedorov, O., Uttarkar, S., Filippakopoulos, P., Picaud, S., Keates, T., Felletar, I., Ciulli, A., Knapp, S. & Heightman, T. D. 1-Oct-2011 In : Molecular BioSystems. 7, 10, p. 2899-2908, 10 p.

    Research output: Contribution to journalArticle

  98. Drug discovery initiative at the University of Dundee: hit-to-lead development for hat and generation of chemical tools

    Grimaldi, R., Urich, R., Sienkiewicz, N., Woodland, A., Urbaniak, M. D., Mathieson, T., Eberhard, D., Bantscheff, M., Drewes, G., Ferguson, M. A. J., Gilbert, I. H., Frearson, J. A., Wyatt, P. G. & Fairlamb, A. H. Oct-2011 In : Tropical Medicine & International Health. 16, Supp. 1, p. 212-212, 1 p.

    Research output: Contribution to journalMeeting abstract

  99. Emerging role of surface plasmon resonance in fragment-based drug discovery

    Navratilova, I. & Hopkins, A. L. Oct-2011 In : Future Medicinal Chemistry. 3, 14, p. 1809-1820, 12 p.

    Research output: Contribution to journalScientific review

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