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  1. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

    Bago, R., Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G. & Alessi, D. R. Nov 2014 In : Biochemical Journal. 463, 3, p. 413-427 15 p.

    Research output: Contribution to journalArticle

  2. The spatial effect of protein deuteration on nitroxide spin-label relaxation: implications for EPR distance measurement

    El Mkami, H., Ward, R., Bowman, A., Owen-Hughes, T. & Norman, D. G. Nov 2014 248, p. 36-41 6 p.

    Research output: Contribution to journalArticle

  3. Characterisation of a melamino nitroheterocycle as a potential lead for the treatment of human African trypanosomiasis

    Giordani, F., Buschini, A., Baliani, A., Kaiser, M., Brun, R., Barrett, M. P., Pellacani, C., Poli, P. & Gilbert, I. H. Oct 2014 In : Antimicrobial Agents and Chemotherapy. 58, 10, p. 5747-5757 11 p.

    Research output: Contribution to journalArticle

  4. Missing pieces of an ancient puzzle: evolution of the Eukaryotic Membrane-Trafficking System

    Schlacht, A., Herman, E. K., Klute, M. J., Field, M. C. & Dacks, J. B. Oct 2014 In : Cold Spring Harbor Perspectives in Biology. 6, 10, a016048

    Research output: Contribution to journalArticle

  5. Reproducible Automated Phosphopeptide Enrichment using Magnetic TiO2 and Ti-IMAC

    Tape, C. J., Worboys, J. D., Sinclair, J., Gourlay, R., Vogt, J., McMahon (Broster), K. M., Trost, M., Lauffenburger, D. A., Lamont, D. J. & Jørgensen, C. 18 Sep 2014 In : Analytical Chemistry. ASAP

    Research output: Contribution to journalArticle

  6. Fragment-Based Screening in Tandem with Phenotypic Screening Provides Novel Antiparasitic Hits

    Blaazer, A. R., Orrling, K. M., Shanmugham, A., Jansen, C., Maes, L., Edink, E., Sterk, G. J., Siderius, M., England, P., Bailey, D., de Esch, I. J. P. & Leurs, R. 17 Sep 2014 In : Journal of Biomolecular Screening.

    Research output: Contribution to journalArticle

  7. Loss of glial neurofascin155 delays developmental synapse elimination at the neuromuscular junction

    Roche, S. L., Sherman, D. L., Dissanayake, K., Soucy, G., Desmazieres, A., Lamont, D. J., Peles, E., Julien, J-P., Wishart, T. M., Ribchester, R. R., Brophy, P. J. & Gillingwater, T. H. 17 Sep 2014 In : Journal of Neuroscience. 34, 38, p. 12904-18 15 p.

    Research output: Contribution to journalArticle

  8. Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile

    Díaz-Sáez, L., Srikannathasan, V., Zoltner, M. & Hunter, W. N. 15 Sep 2014 In : Biochemical Journal. 462, 3, p. 581-589 9 p.

    Research output: Contribution to journalArticle

  9. The design and synthesis of potent and selective inhibitors of trypanosoma brucei glycogen synthase kinase 3 for the treatment of human African trypanosomiasis

    Urich, R., Grimaldi, R., Luksch, T., Frearson, J. A., Brenk, R. & Wyatt, P. G. 8 Sep 2014 In : Journal of Medicinal Chemistry. 57, 18, p. 7536-7549 14 p.

    Research output: Contribution to journalArticle

  10. A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes

    Galvin, B. D., Li, Z., Villemaine, E., Poole, C. B., Chapman, M. S., Pollastri, M. P., Wyatt, P. G. & Carlow, C. K. S. Sep 2014 In : PLoS Neglected Tropical Diseases. 8, 9, 13 p.e3145

    Research output: Contribution to journalArticle

  11. ATP7B activity is stimulated by PKCɛ in porcine liver

    Cardoso, L. H. D., Britto Borges, T., Vieyra, A. & Lowe, J. Sep 2014 In : International Journal of Biochemistry & Cell Biology. 54, p. 60-67 8 p.

    Research output: Contribution to journalArticle

  12. Crystal structure and mechanistic investigation of the twister ribozyme

    Liu, Y., Wilson, T. J., McPhee, S. A. & Lilley, D. M. J. Sep 2014 In : Nature Chemical Biology. 10, 9, p. 739-744 6 p.

    Research output: Contribution to journalArticle

  13. Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains

    Kneuper, H., Cao, Z. P., Twomey, K. B., Zoltner, M., Jäger, F., Cargill, J. S., Chalmers, J., van der Kooi-Pol, M. M., van Dijl, J. M., Ryan, R. P., Hunter, W. N. & Palmer, T. Sep 2014 In : Molecular Microbiology. 93, 5, p. 928-943 15 p.

    Research output: Contribution to journalArticle

  14. Quantification of biliary excretion and sinusoidal excretion of 5(6)-carboxy-2',7'-dichlorofluorescein (CDF) in cultured hepatocytes isolated from Sprague Dawley, Wistar and Mrp2-deficient Wistar (TR-) rats

    Ellis, L. C. J., Grant, M. H., Hawksworth, G. M. & Weaver, R. J. Sep 2014 In : Toxicology in Vitro. 28, 6, p. 1165-1175 11 p.

    Research output: Contribution to journalArticle

  15. Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors

    Lockhart, D. E. A., Schuettelkopf, A., Blair, D. E. & van Aalten, D. M. F. 25 Aug 2014 In : FEBS Letters. 588, 17, p. 3282-3290 9 p.

    Research output: Contribution to journalArticle

  16. Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1

    Khalaf, A. I., Huggan, J. K., Suckling, C. J., Gibson, C. L., Stewart, K., Giordani, F., Barrett, M. P., Wong, P. E., Barrack, K. L. & Hunter, W. N. 14 Aug 2014 In : Journal of Medicinal Chemistry. 57, 15, p. 6479-6494 16 p.

    Research output: Contribution to journalArticle

  17. Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo

    Olivera-Martinez, I., Schurch, N., Li, R., Song, J., Halley, P. A., Das, R. M., Burt, D. W., Barton, G. J. & Storey, K. G. Aug 2014 In : Development. 141, 16, p. 3266-3276 11 p.

    Research output: Contribution to journalArticle

  18. Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human african trypanosomiasis

    Sullivan, L., Fleming, J., Sastry, L., Mehlert, A., Wall, S. J. & Ferguson, M. A. J. 17 Jul 2014 In : PLoS Neglected Tropical Diseases. 8, 7, p. e2976

    Research output: Contribution to journalArticle

  19. Molecular cloning and functional characterization of components of the capsule biosynthesis complex of Neisseria meningitidis serogroup A: toward in vitro vaccine production

    Fiebig, T., Freiberger, F., Pinto, V., Romano, M. R., Black, A., Litschko, C., Bethe, A., Yashunsky, D., Adamo, R., Nikolaev, A., Berti, F. & Gerardy-Schahn, R. 11 Jul 2014 In : Journal of Biological Chemistry. 289, 28, p. 19395-19407 13 p.

    Research output: Contribution to journalArticle

  20. Antigenic variation in African trypanosomes

    Horn, D. Jul 2014 In : Molecular and Biochemical Parasitology. 195, 2, p. 123-129 7 p.

    Research output: Contribution to journalArticle

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