Discovery - University of Dundee - Online Publications

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Biological Chemistry and Drug Discovery

  1. Mutations in POGLUT1 in Galli-Galli /Dowling Degos-disease

    Wilson, N. J., Cole, C., Kroboth, K., Hunter, W. N., Mann, J. A., Irwin McLean, W. H., Kernland Lang, K., Beltraminelli, H., Sabroe, R. A., Tiffin, N., Sobey, G. J., Borradori, L., Simpson, E. & Smith, F. J. D. 1 Aug 2016 In : British Journal of Dermatology.

    Research output: Contribution to journalLetter

  2. MSAViewer: interactive JavaScript visualization of multiple sequence alignments

    Yachdav, G., Wilzbach, S., Rauscher, B., Sheridan, R., Sillitoe, I., Procter, J., Lewis, S. E., Rost, B. & Goldberg, T. 13 Jul 2016 In : Bioinformatics. 3 p.

    Research output: Contribution to journalArticle

  3. Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases

    Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. & Dinkova-Kostova, A. T. 27 Jun 2016 In : Molecular and Cellular Biology.

    Research output: Contribution to journalArticle

  4. Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

    Thomas, J. , Fairlamb, A. H. , Gilbert, I. H. & 61 others Baragaña, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Almeida, M. J., Pradhan, A., Porzelle, A., Santos Martinez, M., Bolscher, J. M., Woodland, A., Luksch, T., Norval, S., Zuccotto, F., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Jiménez-Díaz, M. B., Sanz, L. M., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Javier Gamo, F., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S., Marfurt, J., Price, R. N., Sinden, R. E., Winzeler, E. A., Charman, S. A., Bebrevska, L., Gray, D. W., Campbell, S., Willis, P. A., Rayner, J. C., Fidock, D. A. & Read, K. D. 25 May 2016 In : Nature. 537, 7618, p. 122 1 p.

    Research output: Contribution to journalArticle

  5. Erythematous nodes, urticarial rash and arthralgias in a large pedigree with NLRC4-related autoinflammatory disease, expansion of the phenotype

    Volker-Touw, C. M. L., de Koning, H. D., Giltay, J., de Kovel, C., van Kempen, T. S., Oberndorff, K., Boes, M., van Steensel, M. A. M., van Well, G. T. J., Blokx, W. A. M., Schalkwijk, J., Simon, A., Frenkel, J. & van Gijn, M. E. 20 May 2016 In : British Journal of Dermatology.

    Research output: Contribution to journalLetter

  6. Keratin 12 missense mutation induces the unfolded protein response and apoptosis in meesmann epithelial corneal dystrophy

    Allen, E. H. A., Courtney, D. G., Atkinson, S. D., Moore, J. E., Mairs, L., Poulsen, E. T., Schiroli, D., Maurizi, E., Cole, C., Hickerson, R. P., James, J., Murgatroyd, H., Smith, F. J. D., MacEwen, C., Enghild, J. J., Nesbit, M. A., Leslie Pedrioli, D. M., McLean, W. H. I. & Moore, C. B. T. 15 Mar 2016 In : Human Molecular Genetics. 25, 6, p. 1176-1191 16 p., ddw001

    Research output: Contribution to journalArticle

  7. Goserelin, as an ovarian protector during (neo)adjuvant breast cancer chemotherapy, prevents long term altered bone turnover

    Wilson, C., Gossiel, F., Leonard, R., Anderson, R. A., Adamson, D. J. A., Thomas, G. & Coleman, R. E. Mar 2016 In : Journal of Bone Oncology. 5, 1, p. 43-49 7 p.

    Research output: Contribution to journalArticle

  8. New synthetic routes to Triazolo-benzodiazepine analogues: expanding the scope of the bump-and-hole approach for selective Bromo and Extra-Terminal (BET) bromodomain inhibition

    Baud, M. G. J., Lin-Shiao, E., Zengerle, M., Tallant, C. & Ciulli, A. 25 Feb 2016 In : Journal of Medicinal Chemistry. 59, 4, p. 1492-1500 9 p.

    Research output: Contribution to journalArticle

  9. Biophysical characterization of laforin-carbohydrate interaction

    Dias, D. M., Furtado, J., Wasielewski, E., Cruz, R., Costello, B., Cole, L., Faria, T. Q., Baaske, P., Brito, R. M. M., Ciulli, A., Simões, I., Macedo-Ribeiro, S., Faro, C., Geraldes, C. F. G. C. & Castanheira, P. 1 Feb 2016 In : Biochemical Journal. 473, 3, p. 335-345 11 p.

    Research output: Contribution to journalArticle

  10. Optimization of inhibitors of Mycobacterium tuberculosis pantothenate synthetase based on group efficiency analysis

    Hung, A. W., Silvestre, H. L., Wen, S., George, G. P. C., Boland, J., Blundell, T. L., Ciulli, A. & Abell, C. 5 Jan 2016 In : ChemMedChem. 11, 1, p. 38-42

    Research output: Contribution to journalArticle

  11. StreptomeDB 2.0 - An extended resource of natural products produced by streptomycetes

    Klementz, D., Döring, K., Lucas, X., Telukunta, K. K., Erxleben, A., Deubel, D., Erber, A., Santillana, I., Thomas, O. S., Bechthold, A. & Günther, S. 4 Jan 2016 In : Nucleic Acids Research. 44, D1, p. D509-D514 6 p.

    Research output: Contribution to journalArticle

  12. Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex

    Heider, M. R., Gu, M., Duffy, C. M., Mirza, A. M., Marcotte, L. L., Walls, A. C., Farrall, N., Hakhverdyan, Z., Field, M. C., Rout, M. P., Frost, A. & Munson, M. Jan 2016 In : Nature Structural & Molecular Biology. 23, 1, p. 59-66 8 p.

    Research output: Contribution to journalArticle

  13. The use of the Rx spin label in orientation measurement on proteins, by EPR

    Stevens, M. A., McKay, J. E., Robinson, J. L. S., El Mkami, H., Smith, G. M. & Norman, D. G. 2016 In : Physical Chemistry Chemical Physics. 18, 8, p. 5799-5806 8 p.

    Research output: Contribution to journalArticle

  14. Correction: Modulation of the surface proteome through multiple ubiquitylation pathways in African Trypanosomes

    Zoltner, M., Leung, K. F., Alsford, S., Horn, D. & Field, M. C. 23 Nov 2015 In : PLoS Pathogens. 11, 11, 3 p., e1005291

    Research output: Contribution to journalArticle

  15. Development of small-molecule Trypanosoma brucei N-myristoyltransferase inhibitors: discovery and optimisation of a novel binding mode

    Spinks, D., Smith, V., Thompson, S., Robinson, D. A., Luksch, T., Smith, A., Torrie, L. S., McElroy, S., Stojanovski, L., Norval, S., Collie, I. T., Hallyburton, I., Rao, B., Brand, S., Brenk, R., Frearson, J. A., Read, K. D., Wyatt, P. G. & Gilbert, I. H. Nov 2015 In : ChemMedChem. 10, 11, p. 1821-1836 16 p.

    Research output: Contribution to journalArticle

  16. Discovery of inhibitors of Trypanosoma brucei by phenotypic screening of a focused protein kinase library

    Woodland, A., Thompson, S., Cleghorn, L. A. T., Norcross, N., De Rycker, M., Grimaldi, R., Hallyburton, I., Rao, B., Norval, S., Stojanovski, L., Brun, R., Kaiser, M., Frearson, J. A., Gray, D. W., Wyatt, P. G., Read, K. D. & Gilbert, I. H. Nov 2015 In : ChemMedChem. 10, 11, p. 1809-1820 12 p.

    Research output: Contribution to journalArticle

  17. Modulation of the surface proteome through multiple ubiquitylation pathways in African Trypanosomes

    Zoltner, M., Leung, K. F., Alsford, S., Horn, D. & Field, M. C. 22 Oct 2015 In : PLoS Pathogens. 11, 10, 26 p., e1005236

    Research output: Contribution to journalArticle

  18. Discovery and optimisation studies of antimalarial phenotypic hits

    Mital, A., Murugesan, D., Kaiser, M., Yeates, C. & Gilbert, I. H. 20 Oct 2015 In : European Journal of Medicinal Chemistry. 103, p. 530-538 9 p.

    Research output: Contribution to journalArticle

  19. Discovery of indoline-2-carboxamide derivatives as a new class of brain-penetrant inhibitors of Trypanosoma brucei

    Cleghorn, L. A. T., Albrecht, S., Stojanovski, L., Simeons, F. R. J., Norval, S., Kime, R., Collie, I. T., De Rycker, M., Campbell, L., Hallyburton, I., Frearson, J. A., Wyatt, P. G., Read, K. D. & Gilbert, I. H. 8 Oct 2015 In : Journal of Medicinal Chemistry. 58, 19, p. 7695-7706 12 p.

    Research output: Contribution to journalArticle

  20. Cohort comparison study of cardiac disease and atherosclerotic burden in type 2 diabetic adults using whole body cardiovascular magnetic resonance imaging

    Duce, S. L., Weir-McCall, J. R., Gandy, S. J., Matthew, S. Z., Cassidy, D. B., McCormick, L., Rauchhaus, P., Looker, H., Colhoun, H. M. & Houston, J. G. 18 Sep 2015 In : Cardiovascular Diabetology. 14, 11 p., 122

    Research output: Contribution to journalArticle

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