Discovery - University of Dundee - Online Publications

Library & Learning Centre

Biological Chemistry and Drug Discovery

  1. Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex

    Heider, M. R., Gu, M., Duffy, C. M., Mirza, A. M., Marcotte, L. L., Walls, A. C., Farrall, N., Hakhverdyan, Z., Field, M. C., Rout, M. P., Frost, A. & Munson, M. Jan 2016 In : Nature Structural & Molecular Biology. 23, 1, p. 59-66 8 p.

    Research output: Contribution to journalArticle

  2. Correction: Modulation of the surface proteome through multiple ubiquitylation pathways in African Trypanosomes

    Zoltner, M., Leung, K. F., Alsford, S., Horn, D. & Field, M. C. 23 Nov 2015 In : PLoS Pathogens. 11, 11, 3 p., e1005291

    Research output: Contribution to journalArticle

  3. Development of small-molecule Trypanosoma brucei N-myristoyltransferase inhibitors: discovery and optimisation of a novel binding mode

    Spinks, D., Smith, V., Thompson, S., Robinson, D. A., Luksch, T., Smith, A., Torrie, L. S., McElroy, S., Stojanovski, L., Norval, S., Collie, I. T., Hallyburton, I., Rao, B., Brand, S., Brenk, R., Frearson, J. A., Read, K. D., Wyatt, P. G. & Gilbert, I. H. Nov 2015 In : ChemMedChem. 10, 11, p. 1821-1836 16 p.

    Research output: Contribution to journalArticle

  4. Discovery of inhibitors of Trypanosoma brucei by phenotypic screening of a focused protein kinase library

    Woodland, A., Thompson, S., Cleghorn, L. A. T., Norcross, N., De Rycker, M., Grimaldi, R., Hallyburton, I., Rao, B., Norval, S., Stojanovski, L., Brun, R., Kaiser, M., Frearson, J. A., Gray, D. W., Wyatt, P. G., Read, K. D. & Gilbert, I. H. Nov 2015 In : ChemMedChem. 10, 11, p. 1809-1820 12 p.

    Research output: Contribution to journalArticle

  5. Modulation of the surface proteome through multiple ubiquitylation pathways in African Trypanosomes

    Zoltner, M., Leung, K. F., Alsford, S., Horn, D. & Field, M. C. 22 Oct 2015 In : PLoS Pathogens. 11, 10, 26 p., e1005236

    Research output: Contribution to journalArticle

  6. Discovery and optimisation studies of antimalarial phenotypic hits

    Mital, A., Murugesan, D., Kaiser, M., Yeates, C. & Gilbert, I. H. 20 Oct 2015 In : European Journal of Medicinal Chemistry. 103, p. 530-538 9 p.

    Research output: Contribution to journalArticle

  7. Discovery of indoline-2-carboxamide derivatives as a new class of brain-penetrant inhibitors of Trypanosoma brucei

    Cleghorn, L. A. T., Albrecht, S., Stojanovski, L., Simeons, F. R. J., Norval, S., Kime, R., Collie, I. T., De Rycker, M., Campbell, L., Hallyburton, I., Frearson, J. A., Wyatt, P. G., Read, K. D. & Gilbert, I. H. 8 Oct 2015 In : Journal of Medicinal Chemistry. 58, 19, p. 7695-7706 12 p.

    Research output: Contribution to journalArticle

  8. Leishmania major UDP-sugar pyrophosphorylase salvages galactose for glycoconjugate biosynthesis

    Damerow, S., Hoppe, C., Bandini, G., Zarnovican, P., Buettner, F. F. R., Ferguson, M. A. J. & Routier, F. H. Oct 2015 In : International Journal for Parasitology. 45, 12, p. 783-790 8 p.

    Research output: Contribution to journalArticle

  9. Cohort comparison study of cardiac disease and atherosclerotic burden in type 2 diabetic adults using whole body cardiovascular magnetic resonance imaging

    Duce, S. L., Weir-McCall, J. R., Gandy, S. J., Matthew, S. Z., Cassidy, D. B., McCormick, L., Rauchhaus, P., Looker, H., Colhoun, H. M. & Houston, J. G. 18 Sep 2015 In : Cardiovascular Diabetology. 14, 11 p., 122

    Research output: Contribution to journalArticle

  10. A mutant O-GlcNAcase as a probe to reveal global dynamics of protein O-GlcNAcylation during Drosophila embryonic development

    Mariappa, D., Selvan, N., Borodkin, V. S., Alonso , J., Ferenbach, A. T., Shepherd, C., Navratilova, I. H. & Van Aalten, D. M. F. Sep 2015 In : Biochemical Journal. 470, 2, p. 255-262 8 p.

    Research output: Contribution to journalArticle

  11. Selective small molecule induced degradation of the BET bromodomain protein BRD4

    Zengerle, M., Chan, K-H. & Ciulli, A. 21 Aug 2015 In : ACS Chemical Biology. 10, 8, p. 1770-1777 8 p.

    Research output: Contribution to journalArticle

  12. Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity

    Sola, I., Castellà, S., Viayna, E., Galdeano, C., Taylor, M. C., Gbedema, S. Y., Pérez, B., Clos, M. V., Jones, D. C., Fairlamb, A. H., Wright, C. W., Kelly, J. M. & Muñoz-Torrero, D. 15 Aug 2015 In : Bioorganic & Medicinal Chemistry. 23, 16, p. 5156-5167 12 p.

    Research output: Contribution to journalArticle

  13. Bacillus anthracis meningitis during an outbreak of injectional anthrax, Scotland, UK

    Dewar, S., Weir-McCall, J. R., Batchelor, L., Cole, S. & Parcell, B. J. 1 Aug 2015 In : Clinical Microbiology and Infection. 21, 8, p. e49-e50 2 p.

    Research output: Contribution to journalArticle

  14. Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

    Kazlauskaite, A., Martínez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H. & Muqit, M. M. K. 1 Aug 2015 In : EMBO Reports. 16, 8, p. 939-954 16 p.

    Research output: Contribution to journalArticle

  15. Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

    Graf, F. E., Baker, N., Munday, J. C., de Koning, H. P., Horn, D. & Mäser, P. Aug 2015 In : International Journal for Parasitology: Drugs and Drug Resistance. 5, 2, p. 65-68 4 p.

    Research output: Contribution to journalArticle

  16. Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma brucei

    McCulloch, R. & Field, M. C. Aug 2015 In : Trends in Parasitology. 31, 8, p. 346-349 4 p.

    Research output: Contribution to journalArticle

  17. Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes

    Baker, N., Hamilton, G., Wilkes, J. M., Hutchinson, S., Barrett, M. P. & Horn, D. 21 Jul 2015 In : Proceedings of the National Academy of Sciences of the United States of America. 112, 29, p. 9112-9117 6 p.

    Research output: Contribution to journalArticle

  18. Crystal structures reveal that the reaction mechanism of imidazoleglycerol-phosphate dehydratase is controlled by switching Mn(II) coordination

    Bisson, C., Britton, K. L., Sedelnikova, S. E., Rodgers, H. F., Eadsforth, T. C., Viner, R. C., Hawkes, T. R., Baker, P. J. & Rice, D. W. 7 Jul 2015 In : Structure. 23, 7, p. 1236-1245 10 p.

    Research output: Contribution to journalArticle

  19. Architecture of a host-parasite interface: complex targeting mechanisms revealed through proteomics

    Gadelha, C., Zhang, W., Chamberlain, J. W., Chait, B. T., Wickstead, B. & Field, M. C. Jul 2015 In : Molecular & Cellular Proteomics. 14, 7, p. 1911-1926 16 p.

    Research output: Contribution to journalArticle

  20. N-myristoyltransferase is a cell wall target in Aspergillus fumigatus

    Fang, W., Robinson, D. A., Raimi, O. G., Blair, D. E., Harrison, J. R., Lockhart, D. E. A., Torrie, L. S., Ruda, G. F., Wyatt, P. G., Gilbert, I. H. & van Aalten, D. M. F. 19 Jun 2015 In : ACS Chemical Biology. 10, 6, p. 1425-1434 10 p.

    Research output: Contribution to journalArticle

  21. A novel multiple-stage antimalarial agent that inhibits protein synthesis

    Fairlamb, A. H. , Gilbert, I. H. & 61 others Baragana, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Almeida, M. J., Pradhan, A., Porzelle, A., Santos Martinez, M., Bolscher, J. M., Woodland, A., Norval, S., Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Belén Jiménez-Díaz, M., Maria Sanz, L., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Javier Gamo, F., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S., Marfurt, J., Price, R. N., Sinden, R. E., Winzeler, E. A., Charman, S. A., Bebrevska, L., Gray, D. W., Campbell, S., Willis, P. A., Rayner, J. C., Fidock, D. A. & Read, K. D. 18 Jun 2015 In : Nature. 522, 7556, p. 315-320 6 p.

    Research output: Contribution to journalArticle

  22. Application of RNAi to genomic drug target validation in schistosomes

    Guidi, A., Mansour, N. R., Paveley, R. A., Carruthers, I. M., Besnard, J., Hopkins, A. L., Gilbert, I. H. & Bickle, Q. D. 20 May 2015 In : PLoS Neglected Tropical Diseases. 9, 5, 22 p., e0003801

    Research output: Contribution to journalArticle

  23. Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

    Bulatov, E. & Ciulli, A. 1 May 2015 In : Biochemical Journal. 467, 3, p. 365-386 22 p.

    Research output: Contribution to journalArticle

  24. Crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major

    Barrack, K. L., Fyfe, P. K., Finney, A. J. & Hunter, W. N. May 2015 In : Molecular and Biochemical Parasitology. 201, 1, p. 26-30 5 p.

    Research output: Contribution to journalArticle

  25. Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase

    Robinson, D. A. & Wyatt, P. G. May 2015 In : Acta Crystallographica Section F: Structural Biology Communications. 71, 5, p. 586-593 8 p.

    Research output: Contribution to journalArticle

  26. Macromolecular crystallography and what it can contribute to antiparasite drug discovery

    Hunter, W. N. & Weiss, M. S. May 2015 In : Acta Crystallographica Section F: Structural Biology Communications. 71, 5, p. 483-484 2 p.

    Research output: Contribution to journalEditorial

  27. Identification of caveolar resident proteins in ventricular myocytes using a quantitative proteomic approach: dynamic changes in caveolar composition following adrenoceptor activation

    Wypijewski, K. J., Tinti, M., Chen, W., Lamont, D., Ashford, M. L. J., Calaghan, S. C. & Fuller, W. Mar 2015 In : Molecular & Cellular Proteomics. 14, 3, p. 596-608 13 p.

    Research output: Contribution to journalArticle

  28. Arsenic, antimony, and Leishmania: has arsenic contamination of drinking water in India led to treatment-resistant kala-azar?

    Perry, M., Wyllie, S., Prajapati, V., Menten, J., Raab, A., Feldmann, J., Chakraborti, D., Sundar, S., Boelaert, M., Picado, A. & Fairlamb, A. 26 Feb 2015 In : Lancet. 385, Supplement 1, p. S80 1 p.

    Research output: Contribution to journalArticle

  29. Decreased adipogenesis and adipose tissue in mice with inactivated protein phosphatase 5

    Jacob, W., Rosenzweig, D., Vázquez-Martin, C., Duce, S. L. & Cohen, P. T. W. 15 Feb 2015 In : Biochemical Journal. 466, 1, p. 163-176 14 p.

    Research output: Contribution to journalArticle

  30. Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

    Henderson, C. J., McLaughlin, L. A., Osuna-Cabello, M., Taylor, M., Gilbert, I., McLaren, A. W. & Wolf, C. R. 1 Feb 2015 In : Biochemical Journal. 465, 3, p. 479-488 10 p.

    Research output: Contribution to journalArticle

  31. The Joint European Compound Library: boosting precompetitive research

    Besnard, J., Jones, P. S., Hopkins, A. L. & Pannifer, A. D. Feb 2015 In : Drug Discovery Today. 20, 2, p. 181-186 6 p.

    Research output: Contribution to journalArticle

  32. TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

    Fairlamb, A. H. , Ferguson, M. A. J. & 39 others Shameer, S., Logan-Klumpler, F. J., Vinson, F., Cottret, L., Merlet, B., Achcar, F., Boshart, M., Berriman, M., Breitling, R., Bringaud, F., Bütikofer, P., Cattanach, A. M., Bannerman-Chukualim, B., Creek, D. J., Crouch, K., de Koning, H. P., Denise, H., Ebikeme, C., Ginger, M. L., Hertz-Fowler, C., Kerkhoven, E. J., Mäser, P., Michels, P. A. M., Nayak, A., Nes, D. W., Nolan, D. P., Olsen, C., Silva-Franco, F., Smith, T. K., Taylor, M. C., Tielens, A. G. M., Urbaniak, M. D., van Hellemond, J. J., Vincent, I. M., Wilkinson, S. R., Wyllie, S., Opperdoes, F. R., Barrett, M. P. & Jourdan, F. 28 Jan 2015 In : Nucleic Acids Research. 43, D1, p. D637-D644 8 p.

    Research output: Contribution to journalArticle

  33. Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC

    Tallant, C., Valentini, E., Fedorov, O., Overvoorde, L., Ferguson, F. M., Filippakopoulos, P., Svergun, D. I., Knapp, S. & Ciulli, A. 6 Jan 2015 In : Structure. 23, 1, p. 80-92 13 p.

    Research output: Contribution to journalArticle

  34. Crystals on the cover 2015

    Einspahr, H., Weiss, M. S. & Hunter, W. N. Jan 2015 In : Acta Crystallographica Section F: Structural Biology Communications. F71, 1, p. 1-2 2 p.

    Research output: Contribution to journalArticle

  35. Fragment-Based Screening in Tandem with Phenotypic Screening Provides Novel Antiparasitic Hits

    Blaazer, A. R., Orrling, K. M., Shanmugham, A., Jansen, C., Maes, L., Edink, E., Sterk, G. J., Siderius, M., England, P., Bailey, D., de Esch, I. J. P. & Leurs, R. Jan 2015 In : Journal of Biomolecular Screening. 20, 1, p. 131-140 10 p.

    Research output: Contribution to journalArticle

  36. Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes

    Glover, L., Alsford, S., Baker, N., Turner, D. J., Sanchez-Flores, A., Hutchinson, S., Hertz-Fowler, C., Berriman, M. & Horn, D. Jan 2015 In : Nature Protocols. 10, 1, p. 106-33 28 p.

    Research output: Contribution to journalArticle

  37. 14-3-3-Pred: Improved methods to predict 14-3-3-binding phosphopeptides

    Madeira, F., Tinti, M., Murugesan, G., Berrett, E., Stafford, M., Toth, R., Cole, C., MacKintosh, C. & Barton, G. J. 2015 In : Bioinformatics.

    Research output: Contribution to journalArticle

  38. Arsenic exposure and outcomes of antimonial treatment in visceral leishmaniasis patients in bihar, India: a retrospective cohort study

    Perry, M. R., Prajapati, V. K., Menten, J., Raab, A., Feldmann, J., Chakraborti, D., Sundar, S., Fairlamb, A. H., Boelaert, M. & Picado, A. 2015 In : PLoS Neglected Tropical Diseases. 9, 3, 17 p., e0003518

    Research output: Contribution to journalArticle

  39. Development and applications of biosensor assays for fragment screening of wild-type GPCRs

    Hopkins Navratilova, I. & Fagge, T. 2015 In : European Pharmaceutical Review. 20, 6, p. 29-31 3 p.

    Research output: Contribution to journalArticle

  40. ENTH and ANTH domain proteins participate in AP2-independent clathrin-mediated endocytosis

    Manna, P. T., Gadelha, C., Puttick, A. E. & Field, M. C. 2015 In : Journal of Cell Science. 128, 11, p. 2130-2142 13 p.

    Research output: Contribution to journalArticle

  41. Identification of a glycosylphosphatidylinositol anchor-modifying β1-3 galactosyltransferase in Trypanosoma brucei

    Izquierdo, L., Acosta-Serrano, A., Mehlert, A. & Ferguson, M. A. J. 2015 In : Glycobiology. 25, 4, p. 438-447 50 p.

    Research output: Contribution to journalArticle

  42. New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource

    Peña, I. , Pilar Manzano, M. , Cantizani, J. , Kessler, A. , Alonso-Padilla, J. , Bardera, A. I. , Alvarez, E. , Colmenarejo, G. , Cotillo, I. , Roquero, I. , de Dios-Anton, F. , Barroso, V. , Rodriguez, A. , Gray, D. W. , Navarro, M. , Kumar, V. , Sherstnev, A. , Drewry, D. H. , Brown, J. R. , Fiandor, J. M. & 1 others Julio Martin, J. 2015 In : Scientific Reports. 5, 12 p., 8771

    Research output: Contribution to journalArticle

  43. New synthetic routes to Triazolo-benzodiazepine analogues: expanding the scope of the bump-and-hole approach for selective Bromo and Extra-Terminal (BET) bromodomain inhibition

    Baud, M. G. J., Lin-Shiao, E., Zengerle, M., Tallant, C. & Ciulli, A. 2015 In : Journal of Medicinal Chemistry. 9 p.

    Research output: Contribution to journalArticle

  44. Optimization of inhibitors of Mycobacterium tuberculosis pantothenate synthetase based on group efficiency analysis

    Hung, A. W., Silvestre, H. L., Wen, S., George, G. P. C., Boland, J., Blundell, T. L., Ciulli, A. & Abell, C. 2015 In : ChemMedChem. 6 p.

    Research output: Contribution to journalArticle

  45. Surface plasmon resonance analysis of seven-transmembrane receptors

    Aristotelous, T., Hopkins, A. L. & Navratilova, I. 2015 Membrane proteins—production and functional characterization. Shukla, A. K. (ed.). Academic Press, p. 499-525 27 p. (Methods in Enzymology; vol. 556)

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  46. The importance of triaging in determining the quality of output from high-throughput screening

    Jones, P., McElroy, S., Morrison, A. & Pannifer, A. 2015 In : Future Medicinal Chemistry. 7, 14, p. 1847-1852 6 p.

    Research output: Contribution to journalComment/debate

  47. PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia

    Mudie, S., Bandarra, D., Batie, M., Biddlestone, J., Moniz, S., Ortmann, B., Shmakova, A. & Rocha, S. 15 Dec 2014 In : Cell Cycle. 13, 24, p. 3878-3891 14 p.

    Research output: Contribution to journalArticle

  48. O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signalling?

    Alonso , J., Schimpl, M. & van Aalten, D. M. F. 12 Dec 2014 In : Journal of Biological Chemistry. 289, 50, p. 34433-34439 7 p.

    Research output: Contribution to journalArticle

Previous 1 2 3 4 5 6 7 8 ...20 Next

Find Research Units in Discovery

Library & Learning Centre

Contact | Accessibility | Policy