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  1. ATP7B activity is stimulated by PKCɛ in porcine liver

    Cardoso, L. H. D., Britto Borges, T., Vieyra, A. & Lowe, J. Sep 2014 In : International Journal of Biochemistry & Cell Biology. 54, p. 60-67 8 p.

    Research output: Contribution to journalArticle

  2. Quantification of biliary excretion and sinusoidal excretion of 5(6)-carboxy-2',7'-dichlorofluorescein (CDF) in cultured hepatocytes isolated from Sprague Dawley, Wistar and Mrp2-deficient Wistar (TR-) rats

    Ellis, L. C. J., Grant, M. H., Hawksworth, G. M. & Weaver, R. J. Sep 2014 In : Toxicology in Vitro. 28, 6, p. 1165-1175 11 p.

    Research output: Contribution to journalArticle

  3. Molecular cloning and functional characterization of components of the capsule biosynthesis complex of Neisseria meningitidis serogroup A: toward in vitro vaccine production

    Fiebig, T., Freiberger, F., Pinto, V., Romano, M. R., Black, A., Litschko, C., Bethe, A., Yashunsky, D., Adamo, R., Nikolaev, A., Berti, F. & Gerardy-Schahn, R. 11 Jul 2014 In : Journal of Biological Chemistry. 289, 28, p. 19395-19407 13 p.

    Research output: Contribution to journalArticle

  4. C-reactive protein is essential for innate resistance to pneumococcal infection

    Simons, J. P., Loeffler, J. M., Al-Shawi, R., Ellmerich, S., Hutchinson, W. L., Tennent, G. A., Petrie, A., Raynes, J. G., de Souza, J. B., Lawrence, R. A., Read, K. D. & Pepys, M. B. Jul 2014 In : Immunology. 142, 3, p. 414-420 7 p.

    Research output: Contribution to journalArticle

  5. Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

    Cole, C., Kroboth, K., Schurch, N. J., Sandilands, A., Sherstnev, A., O'Regan, G. M., Watson, R. M., McLean, W. H. I., Barton, G. J., Irvine, A. D. & Brown, S. J. Jul 2014 In : Journal of Allergy and Clinical Immunology. 134, 1, p. 82-91 10 p.

    Research output: Contribution to journalArticle

  6. Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human african trypanosomiasis

    Sullivan, L., Fleming, J., Sastry, L., Mehlert, A., Wall, S. J. & Ferguson, M. A. J. Jul 2014 In : PLoS Neglected Tropical Diseases. 8, 7, p. e2976

    Research output: Contribution to journalArticle

  7. Validity of ligand efficiency metrics

    Murray, C. W., Erlanson, D. A., Hopkins, A. L., Keserü, G. M., Leeson, P. D., Rees, D. C., Reynolds, C. H. & Richmond, N. J. 12 Jun 2014 In : ACS Medicinal Chemistry Letters. 5, 6, p. 616-618 3 p.

    Research output: Contribution to journalArticle

  8. Glycogen Synthase Kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells

    Sarshad, A. A., Corcoran, M., Al-Muzzaini, B., Borgonovo-Brandter, L., Von Euler, A., Lamont, D., Visa, N. & Percipalle, P. 5 Jun 2014 In : PLoS Genetics. 10, 6, 17 p.e1004390

    Research output: Contribution to journalArticle

  9. TbGT8 is a bifunctional glycosyltransferase that elaborates N-linked glycans on a protein phosphatase AcP115 and a GPI-anchor modifying glycan in Trypanosoma brucei

    Nakanishi, M., Karasudani, M., Shiraishi, T., Hashida, K., Hino, M., Ferguson, M. A. J. & Nomoto, H. Jun 2014 In : Parasitology International. 63, 3, p. 513-518 6 p.

    Research output: Contribution to journalArticle

  10. Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei

    Alsford, S., Currier, R. B., Guerra-Assunção, J. A., Clark, T. G. & Horn, D. 15 May 2014 In : PLoS Pathogens. 10, 5, 12 p.e1004130

    Research output: Contribution to journalArticle

  11. Nuclear pore complex evolution: a trypanosome Mlp analogue functions in chromosomal segregation but lacks transcriptional barrier activity

    Holden, J. M., Koreny, L., Obado, S., Ratushny, A. V., Chen, W-M., Chiang, J-H., Kelly, S., Chait, B. T., Aitchison, J. D., Rout, M. P. & Field, M. C. 1 May 2014 In : Molecular Biology of the Cell. 25, 9, p. 1421-1436 16 p.

    Research output: Contribution to journalArticle

  12. Life and times: synthesis, trafficking, and evolution of VSG

    Manna, P. T., Boehm, C., Leung, K. F., Natesan, S. K. & Field, M. C. May 2014 In : Trends in Parasitology. 30, 5, p. 251-258 8 p.

    Research output: Contribution to journalArticle

  13. The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma brucei

    Lilley, A. C., Major, L., Young, S., Stark, M. J. R. & Smith, T. K. May 2014 In : Molecular Microbiology. 92, 3, p. 453-470 18 p.

    Research output: Contribution to journalArticle

  14. Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase

    Roberts, A. J., Torrie, L. S., Wyllie, S. & Fairlamb, A. H. 15 Apr 2014 In : Biochemical Journal. 459, 2, p. 323-332 10 p.

    Research output: Contribution to journalArticle

  15. Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy

    Wishart, T. M. , Mutsaers, C. A. , Riessland, M. , Reimer, M. M. , Hunter, G. , Hannam, M. L. , Eaton, S. L. , Fuller, H. R. , Roche, S. L. , Somers, E. , Morse, R. , Young, P. J. , Lamont, D. J. , Hammerschmidt, M. , Joshi, A. , Hohenstein, P. , Morris, G. E. , Parson, S. H. , Skehel, P. A. , Becker, T. & 4 others Robinson, I. M., Becker, C. G., Wirth, B. & Gillingwater, T. H. 1 Apr 2014 In : Journal of Clinical Investigation. 124, 4, p. 1821-1834 14 p.

    Research output: Contribution to journalArticle

  16. A novel marker, ARM58, confers antimony resistance to Leishmania spp

    Nuhs, A., Schäfer, C., Zander, D., Trübe, L., Tejera Nevado, P., Schmidt, S., Arevalo, J., Adaui, V., Maes, L., Dujardin, J-C. & Clos, J. Apr 2014 In : International Journal for Parasitology: Drugs and Drug Resistance. 4, 1, p. 37-47 11 p.

    Research output: Contribution to journalArticle

  17. Structure of a rare non-standard sequence k-turn bound by L7Ae protein

    Huang, L. & Lilley, D. M. J. Apr 2014 In : Nucleic Acids Research. 42, 7, p. 4734-4740 7 p.

    Research output: Contribution to journalArticle

  18. The k-junction motif in RNA structure

    Wang, J., Daldrop, P., Huang, L. & Lilley, D. M. J. Apr 2014 In : Nucleic Acids Research. 42, 8, p. 5322-5331 10 p.

    Research output: Contribution to journalArticle

  19. Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase

    Urbaniak, M. D., Capes, A. S., Crossman, A., O'Neill, S., Thompson, S., Gilbert, I. H. & Ferguson, M. A. J. 31 Mar 2014 In : Carbohydrate Research. 387, p. 54-58 5 p.

    Research output: Contribution to journalArticle

  20. Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei

    Damerow, M., Rodrigues, J. A., Wu, D., Güther, M. L. S., Mehlert, A. & Ferguson, M. A. J. 28 Mar 2014 In : Journal of Biological Chemistry. 289, 13, p. 9328-9339 12 p.

    Research output: Contribution to journalArticle

  21. How the structure of the large subunit controls function in an oxygen-tolerant [NiFe]-hydrogenase

    Bowman, L., Flanagan, L., Fyfe, P. K., Parkin, A., Hunter, W. N. & Sargent, F. 15 Mar 2014 In : Biochemical Journal. 458, 3, p. 449-458 10 p.

    Research output: Contribution to journalArticle

  22. High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei.

    McGregor, P., Ivens, A., Shave, S., Collie, I., Gray, D., Auer, M. & Matthews, K. R. Mar 2014 In : Eukaryotic Cell. 13, 3, p. 412-426 15 p.

    Research output: Contribution to journalArticle

  23. Predicting hydration free energies with chemical accuracy: the SAMPL4 challenge

    Sandberg, L. Mar 2014 In : Journal of Computer-Aided Molecular Design. 28, 3, p. 211-219 9 p.

    Research output: Contribution to journalArticle

  24. Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues

    Capes, A. S., Crossman, A., Urbaniak, M. D., Gilbert, S. H., Ferguson, M. A. J. & Gilbert, I. H. Mar 2014 In : Organic and Biomolecular Chemistry. 12, 12, p. 1919-1934 16 p.

    Research output: Contribution to journalArticle

  25. Norspermidine is not a self-produced trigger for biofilm disassembly

    Hobley, L., Kim, S. H., Maezato, Y., Wyllie, S., Fairlamb, A. H., Stanley-Wall, N. R. & Michael, A. J. 13 Feb 2014 In : Cell. 156, 4, p. 844-854 11 p.

    Research output: Contribution to journalArticle

  26. Evolution of the nucleus

    Devos, D. P., Gräf, R. & Field, M. C. 5 Feb 2014 In : Current Opinion in Cell Biology. 28, p. 8-15 8 p.

    Research output: Contribution to journalArticle

  27. Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors

    Borodkin, V. S., Schimpl, M., Gundogdu, M., Rafie, K., Dorfmueller, H. C., Robinson, D. A. & van Aalten, D. M. F. 1 Feb 2014 In : Biochemical Journal. 457, 3, p. 497-502 6 p.

    Research output: Contribution to journalArticle

  28. The cyclic AMP phosphodiesterase RegA critically regulates encystation in social and pathogenic amoebas

    Du, Q., Schilde, C., Birgersson, E., Chen, Z-H., McElroy, S. & Schaap, P. Feb 2014 In : Cellular Signalling. 26, 2, p. 453-459 7 p.

    Research output: Contribution to journalArticle

  29. Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei

    Mony, B. M., MacGregor, P., Ivens, A., Rojas, F., Cowton, A., Young, J., Horn, D. & Matthews, K. 30 Jan 2014 In : Nature. 505, 7485, p. 681-685 5 p.

    Research output: Contribution to journalLetter

  30. In Vitro and In Vivo studies of trypanocidal activity of dietary isothiocyanates

    Steverding, D., Michaels, S. & Read, K. D. 22 Jan 2014 In : Planta Medica.

    Research output: Contribution to journalLetter

  31. Is NMR fragment screening fine-tuned to assess druggability of protein-protein interactions?

    Dias, D. M., Van Molle, I., Baud, M. G. J., Galdeano, C., Geraldes, C. F. G. C. & Ciulli, A. 9 Jan 2014 In : ACS Medicinal Chemistry Letters. 5, 1, p. 23-28 6 p.

    Research output: Contribution to journalLetter

  32. Crystals on the cover 2014

    Einspahr, H., Weiss, M. S. & Hunter, W. N. Jan 2014 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 70, 1, p. 1 1 p.

    Research output: Contribution to journalEditorial

  33. A structural and biochemical model of processive chitin synthesis

    Dorfmueller, H. C., Ferenbach, A. T., Borodkin, V. S. & van Aalten, D. M. F. 2014 In : Journal of Biological Chemistry.

    Research output: Contribution to journalArticle

  34. Antiparasitic chemotherapy: from genomes to mechanisms

    Horn, D. & Duraisingh, M. T. 2014 In : Annual Review of Pharmacology and Toxicology. 54, p. 71-94 24 p.

    Research output: Contribution to journalArticle

  35. Characterisation of a melamino nitroheterocycle as a potential lead for the treatment of human African trypanosomiasis

    Giordani, F., Buschini, A., Baliani, A., Kaiser, M., Brun, R., Barrett, M. P., Pellacani, C., Poli, P. & Gilbert, I. H. 2014 In : Antimicrobial Agents and Chemotherapy.

    Research output: Contribution to journalArticle

  36. Crystal structure and mechanistic investigation of the twister ribozyme

    Liu, Y., Wilson, T. J., McPhee, S. A. & Lilley, D. M. J. 2014 In : Nature Chemical Biology.

    Research output: Contribution to journalArticle

  37. Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ES cell differentiation without affecting naive to primed cell transition

    Speakman, C. M., Domke, T. C. E., Wongpaiboonwattana, W., Sanders, K., Mudaliar, M., van Aalten, D. M. F., Barton, G. J. & Stavridis, M. P. 2014 In : Stem Cells.

    Research output: Contribution to journalArticle

  38. Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors

    Casale, E., Amboldi, N., Brasca, . M. G., Caronni, D., Colombo, N., Dalvit, C., Felder, E. R., Fogliatto, G., Galvani, A., Isacchi, A., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F. & Casuscelli, F. 2014 In : Bioorganic & Medicinal Chemistry. 22, 15, p. 4135-4150 16 p.

    Research output: Contribution to journalArticle

  39. Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains

    Kneuper, H., Cao, Z. P., Twomey, K. B., Zoltner, M., Jäger, F., Cargill, J. S., Chalmers, J., van der Kooi-Pol, M. M., van Dijl, J. M., Ryan, R. P., Hunter, W. N. & Palmer, T. 2014 In : Molecular Microbiology.

    Research output: Contribution to journalArticle

  40. High-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC proteomics

    Güther, M. L. S., Urbaniak, M., Tavendale, A., Prescott, A. & Ferguson, M. A. J. 2014 In : Journal of Proteome Research. 13, 6, p. 2796-2806 11 p.

    Research output: Contribution to journalArticle

  41. Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers

    Tinti, M., Dissanayake, K., Synowsky, S., Albergante, L. & Mackintosh, C. 2014 In : Open Biology. 4, May, 16 p.140029

    Research output: Contribution to journalArticle

  42. Improved annotation of 3' untranslated regions and complex loci by combination of strand-specific direct RNA sequencing, RNA-seq and ESTs

    Schurch, N. J., Cole, C., Sherstnev, A., Song, J., Duc, C., Storey, K. G., McLean, W. H. I., Brown, S. J., Simpson, G. G. & Barton, G. J. 2014 In : PLoS ONE. 9, 4, e94270

    Research output: Contribution to journalArticle

  43. Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo

    Olivera-Martinez, I., Schurch, N., Li, R. A., Song, J., Halley, P. A., Das, R. M., Burt, D. W., Barton, G. J. & Storey, K. G. 2014 In : Development. 11 p.

    Research output: Contribution to journalArticle

  44. Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK

    Hunter, R. W., Foretz, M., Bultot, L., Fullerton, M. D., Deak, M., Ross, F. A., Hawley, S. A., Shpiro, N., Viollet, B., Barron, D., Kemp, B. E., Steinberg, G. R., Hardie, D. G. & Sakamoto, K. 2014 In : Chemistry & Biology. 21, 7, p. 866-879 14 p.

    Research output: Contribution to journalArticle

  45. Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects

    Patterson, S. & Wyllie, S. 2014 In : Trends in Parasitology. 30, 6, p. 289-298 10 p.

    Research output: Contribution to journalArticle

  46. Proteomic Selection of Immunodiagnostic Antigens for Trypanosoma congolense

    Fleming, J. R., Sastry, L., Crozier, T. W. M., Napier, G. B., Sullivan, L. & Ferguson, M. A. J. 2014 In : PLoS Neglected Tropical Diseases. 8, 6, e2936

    Research output: Contribution to journalArticle

  47. Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling

    Atrih, A., Mudaliar, M. A. V., Zakikhani, P., Lamont, D. J., Huang, J. T-J., Bray, S. E., Barton, G., Fleming, S. & Nabi, G. 2014 In : British Journal of Cancer. 110, 6, p. 1622-1633 12 p.

    Research output: Contribution to journalArticle

  48. Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors

    Lockhart, D. E. A., Schuettelkopf, A., Blair, D. & van Aalten, D. M. F. 2014 In : FEBS Letters. 588, 17, p. 3282-3290 9 p.

    Research output: Contribution to journalArticle

  49. Standardizing biochemistry dataset for medical research

    Bonney, W., Doney, A. & Jefferson, E. 2014 HEALTHINF 2014 - 7th International Conference on Health Informatics, Proceedings; Part of 7th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2014. p. 205-210 6 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  50. Structure-based virtual screening for the identification of RNA-binding ligands

    Daldrop, P. & Brenk, R. 2014 Therapeutic applications of ribozymes and riboswitches: methods and protocols. Lafontaine, D. & Dubé, A. (eds.). Humana Press, p. 127-139 13 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

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