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  1. Global Quantitative SILAC Phosphoproteomics Reveals Differential Phosphorylation Is Widespread between the Procyclic and Bloodstream Form Lifecycle Stages of Trypanosoma brucei

    Urbaniak, M. D., Martin, D. M. A. & Ferguson, M. A. J. 3-May-2013 In : Journal of Proteome Research. 12, 5, p. 2233-2244, 12 p.

    Research output: Contribution to journal › Article

  2. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

    Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P. 1-May-2013 In : Biochemical Journal. 451, 3, p. 427-437, 11 p.

    Research output: Contribution to journal › Article

  3. Improved sperm function / activity

    Barratt, C. & Wyatt, P. 18-Apr-2013 WO2013054111 A1

    Research output: Patent

  4. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

    Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3-Apr-2013 In : EMBO Journal. 32, 7, p. 1008-22, 15 p.

    Research output: Contribution to journal › Article

  5. The architecture of EssB, an integral membrane component of the type VII secretion system

    Zoltner, M., Norman, D. G., Fyfe, P. K., El Mkami, H., Palmer, T. & Hunter, W. N. 2-Apr-2013 In : Structure. 21, 4, p. 595-603, 9 p.

    Research output: Contribution to journal › Article

  6. The importance of the N-terminus of T7 endonuclease I in the interaction with DNA junctions

    Freeman, A. D. J., Déclais, A-C. & Lilley, D. M. J. 23-Jan-2013 In : Journal of Molecular Biology. 425, 2, p. 395-410, 16 p.

    Research output: Contribution to journal › Article

  7. Characterization of Staphylococcus aureus EssB, an integral membrane component of the Type VII secretion system: atomic resolution crystal structure of the cytoplasmic segment

    Zoltner, M., Fyfe, P. K., Palmer, T. & Hunter, W. N. 15-Jan-2013 In : Biochemical Journal. 449, 2, p. 469-477, 9 p.

    Research output: Contribution to journal › Article

  8. PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway

    Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15-Jan-2013 In : Journal of Immunology. 190, 2, p. 565-77, 13 p.

    Research output: Contribution to journal › Article

  9. A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle

    Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., Shattock, M. J., Calaghan, S. C. & Fuller, W. 2013 In : Journal of Biological Chemistry.

    Research output: Contribution to journal › Article

  10. A sweet TET-a-tete-synergy of TET proteins and O-GlcNAc transferase in transcription

    Mariappa, D., Pathak, S. & van Aalten, D. M. F. 2013 In : EMBO Journal. 32, 5, p. 612-613, 2 p.

    Research output: Contribution to journal › Editorial

  11. Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.

    De Rycker, M., Hallyburton, I., Thomas, J., Campbell, L., Wyllie, S., Joshi, D., Cameron, S., Gilbert, I. H., Wyatt, P. G., Frearson, J. A., Fairlamb, A. H. & Gray, D. W. 2013 In : Antimicrobial Agents and Chemotherapy.

    Research output: Contribution to journal › Article

  12. Electromechanical Behaviour of Nafion-based Soft Actuators

    Naji, L., Chudek, J. A., Abel, E. W. & Baker, R. T. 2013 In : Journal of Physical Chemistry B. 1, 19, p. 2502-2514, 13 p.

    Research output: Contribution to journal › Article

  13. Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry

    Hahne, H., Sobotzki, N., Nyberg, T., Helm, D., Borodkin, V. S., van Aalten, D. M. F., Agnew, B. & Kuster, B. 2013 In : Journal of Proteome Research. 12, 2, p. 927-936, 10 p.

    Research output: Contribution to journal › Article

  14. Regulation of the cardiac Na(+) pump by palmitoylation of its catalytic and regulatory subunits

    Howie, J., Tulloch, L. B., Shattock, M. J. & Fuller, W. 2013 In : Biochemical Society Transactions. 41, 1, p. 95-100, 6 p.

    Research output: Contribution to journal › Article

  15. Structure of Pseudomonas aeruginosa inosine 5-monophosphate dehydrogenase

    Rao, V. A., Shepherd, S. M., Owen, R. & Hunter, W. N. 2013 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 3, p. 243-247, 5 p.

    Research output: Contribution to journal › Article

  16. The plasticity of a structural motif in RNA: Structural polymorphism of a kink turn as a function of its environment

    Daldrop, P. & Lilley, D. M. J. 2013 In : RNA: a Publication of the RNA Society. 19, 3, p. 357-364, 8 p.

    Research output: Contribution to journal › Article

  17. Automated design of ligands to polypharmacological profiles

    Gilbert, I. H. & 20 others Besnard, J., Ruda, G. F., Setola, V., Abecassis, K., Rodriguiz, R. M., Huang, X-P., Norval, S., Sassano, M. F., Shin, A. I., Webster, L. A., Simeons, F. R. C., Stojanovski, L., Prat, A., Seidah, N. G., Constam, D. B., Bickerton, G. R., Read, K. D., Wetsel, W. C., Roth, B. L. & Hopkins, A. L. 13-Dec-2012 In : Nature. 492, 7428, p. 215-+, 8 p.

    Research output: Contribution to journal › Article

  18. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P-3-dependent mechanisms leading to resistance to PDK1 inhibitors

    Najafov, A., Shpiro, N. & Alessi, D. R. Dec-2012 In : Biochemical Journal. 448, 2, p. 285-295, 11 p.

    Research output: Contribution to journal › Article

  19. A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes

    De Rycker, M., O'Neill, S., Joshi, D., Campbell, L., Gray, D. W. & Fairlamb, A. H. 29-Nov-2012 In : PLoS Neglected Tropical Diseases. 6, 11, p. e1932

    Research output: Contribution to journal › Article

  20. Structural plasticity of histones H3–H4 facilitates their allosteric exchange between RbAp48 and ASF1

    Zhang, W., Yyl, M., Ward, R., Sobott, F., Maman, J., Murthy, A., Watson, A., Fedorov, O., Bowman, A., Owen-Hughes, T., El Mkami, H., Murzina, N., Norman, D. G. & Laue, E. 25-Nov-2012 In : Nature Structural & Molecular Biology. 20, 1, p. 29-35

    Research output: Contribution to journal › Article

  21. Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α

    Buckley, D. L., Gustafson, J. L., Van-Molle, I., Roth, A. G., Tae, H. S., Gareiss, P. C., Jorgensen, W. L., Ciulli, A. & Crews, C. M. 12-Nov-2012 In : Angewandte Chemie International Edition. 51, 46, p. 11463-11467, 5 p.

    Research output: Contribution to journal › Article

  22. Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei

    Urbaniak, M. D., Mathieson, T., Bantscheff, M., Eberhard, D., Grimaldi, R., Miranda-Saavedra, D., Wyatt, P., Ferguson, M. A. J., Frearson, J. & Drewes, G. Nov-2012 In : ACS Chemical Biology. 7, 11, p. 1858-1865, 8 p.

    Research output: Contribution to journal › Article

  23. Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma

    Pohler, E. , Mamai, O. , Hirst, J. , Zamiri, M. , Horn, H. , Nomura, T. , Irvine, A. D. , Moran, B. , Wilson, N. J. , Smith, F. J. D. , Goh, C. S. M. , Sandilands, A. , Cole, C. , Barton, G. J. , Evans, A. T. , Shimizu, H. , Akiyama, M. , Suehiro, M. , Konohana, I. , Shboul, M. & 12 others Teissier, S., Boussofara, L., Denguezli, M., Saad, A., Gribaa, M., Dopping-Hepenstal, P. J., McGrath, J. A., Brown, S. J., Goudie, D. R., Reversade, B., Munro, C. S. & McLean, W. H. I. Nov-2012 In : Nature Genetics. 44, 11, p. 1272-1276, 5 p.

    Research output: Contribution to journal › Article

  24. New secreted toxins and immunity proteins encoded within the type VI secretion system gene cluster of Serratia marcescens

    English, G., Trunk, K., Rao, V. A., Srikannathasan, V., Hunter, W. N. & Coulthurst, S. J. Nov-2012 In : Molecular Microbiology. 86, 4, p. 921-936, 16 p.

    Research output: Contribution to journal › Article

  25. Dissecting fragment-based lead discovery at the von hippel-lindau protein: Hypoxia inducible factor 1α protein-protein interface

    Van Molle, I., Thomann, A., Buckley, D. L., So, E. C., Lang, S., Crews, C. M. & Ciulli, A. 26-Oct-2012 In : Chemistry & Biology. 19, 10, p. 1300-1312, 13 p.

    Research output: Contribution to journal › Article

  26. Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

    Jones, D. C., Alphey, M. S., Wyllie, S. & Fairlamb, A. H. Oct-2012 In : Molecular Microbiology. 86, 1, p. 51-64, 14 p.

    Research output: Contribution to journal › Article

  27. Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121

    Hudson, S. A., McLean, K. J., Surade, S., Yang, Y-Q., Leys, D., Ciulli, A., Munro, A. W. & Abell, C. 10-Sep-2012 In : Angewandte Chemie International Edition. 51, 37, p. 9311-9316, 6 p.

    Research output: Contribution to journal › Article

  28. Transcriptome analysis of atopic skin demonstrates the importance of extracellular mechanisms in the filaggrin-related barrier defect

    Brown, S., Cole, C., McLean, I., Barton, G. & Irvine, A. Sep-2012 In : Journal of Investigative Dermatology. 132, p. S94-S94, 1 p.

    Research output: Contribution to journal › Meeting abstract

  29. Essential Role for IKK beta in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

    Pauls, E., Shpiro, N., Peggie, M., Young, E. R., Sorcek, R. J., Tan, L., Choi, H. G. & Cohen, P. 1-Jun-2012 In : Journal of Biological Chemistry. 287, 23, p. 19216-19228, 13 p.

    Research output: Contribution to journal › Article

  30. Pathways analysis in kidney cancer using proteomics approach

    Zakikhani, M., Atrih, A., Lamont, S. R., Goodman, C., Fleming, I. N. & Nabi, G. Jun-2012 In : BJU International. 109, p. 24-24, 1 p.

    Research output: Contribution to journal › Special issue

  31. Structure and folding of a rare, natural kink turn in RNA with an A•A pair at the 2•d2n position

    Schroeder, K. T., Daldrop, P., McPhee, S. A. & Lilley, D. M. J. Jun-2012 In : RNA: a Publication of the RNA Society. 18, 6, p. 1257-1266, 10 p.

    Research output: Contribution to journal › Article

  32. Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation

    Klotz-Noack, K., McIntosh, D., Schurch, N., Pratt, N. & Blow, J. J. 15-May-2012 In : Journal of Cell Science. 125, 10, p. 2436-2445, 10 p.

    Research output: Contribution to journal › Article

  33. Combining PET biodistribution and equilibrium dialysis assays to assess the free brain concentration and BBB transport of CNS drugs

    Gunn, R. N., Summerfield, S. G., Salinas, C. A., Read, K. D., Guo, Q., Searle, G. E., Parker, C. A., Jeffrey, P. & Laruelle, M. May-2012 In : Journal of Cerebral Blood Flow and Metabolism. 32, 5, p. 874-883, 10 p.

    Research output: Contribution to journal › Article

  34. Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo

    Hack, K., Reilly, L., Palmer, C., Read, K., Norval, S., Kime, R., Booth, K. & Foerster, J. May-2012 In : PLoS ONE. 7, 5

    Research output: Contribution to journal › Article

  35. The lipid-linked oligosaccharide donor specificities of Trypanosoma brucei oligosaccharyltransferases

    Izquierdo, L., Mehlert, A. & Ferguson, M. A. J. May-2012 In : Glycobiology. 22, 5, p. 696-703, 8 p.

    Research output: Contribution to journal › Article

  36. Guidelines for the use and interpretation of assays for monitoring autophagy

    Klionsky, D. J. , Backues, S. K. , Bartholomew, C. R. , Bridges, D. , Gestwicki, J. E. , Han, T. , Jin, M. , Kim, J. K. , Lin, J. D. , Lynch-Day, M. A. , Mao, K. , Nair, U. , Parzych, K. R. , Umekawa, M. , Wang, K. , Yen, W-L. , Zhao, M. , Olsen, L. J. , Abdalla, F. C. , Marcondes, M. & 1,235 others Silva-Zacarin, E. C. M., Silva-Zacarin, E., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Chiarelli, R., Roccheri, M. C., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., Ait-Si-Ali, S., Akematsu, T., Akira, S., Saitoh, T., Al-Younes, H. M., Al-Zeer, M. A., Meyer, T. F., Albert, M. L., Albin, R. L., Dowling, J. J., Alegre-Abarrategui, J., Wade-Martins, R., Aleo, M. F., Fanzani, A., Rovetta, F., Alirezaei, M., Chisari, F. V., Whitton, J. L., Almasan, A., Almonte-Becerril, M., Kouri Flores, J. B., Amano, A., Amaravadi, R., Amarnath, S., Fowler, D. H., Amer, A. O., Drew, M. E., Andrieu-Abadie, N., Poirot, M., Vindis, C., Anantharam, V., Kanthasamy, A. G., Kanthasamy, A., Ann, D. K., Anoopkumar-Dukie, S., Grant, G. D., Aoki, H., Apostolova, N., Arancia, G., Condello, M., Meschini, S., Aris, J. P., Asanuma, K., Tomino, Y., Asare, N. Y. O., Ashida, H., Askanas, V., Nogalska, A., Askew, D. S., Auberger, P., Bost, F., Gual, P., Luciano, F., Rocchi, S., Baba, M., Baehrecke, E. H., Bahr, B. A., Bai, X-Y., Chen, X., Bailly, Y., Baiocchi, R., Baldini, G., Balduini, W., Ballabio, A., Brunetti-Pierri, N., Settembre, C., Bamber, B. A., Bampton, E. T. W., Melino, G., Bánhegyi, G., Bassham, D. C., Bast Jr., R. C., Fan, Z., Lopez-Berestein, G., Lu, Z., Ozpolat, B., Batoko, H., Bay, B-H., Beau, I., Esclatine, A., Béchet, D. M., Begley, T. J., Behl, C., Behrends, C., Dikic, I., Bekri, S., Bellaire, B., Bendall, L. J., Benetti, L., Berliocchi, L., Bernardi, H., Sanchez, A. M. J., Bernassola, F., Marfe, G., Palumbo, C., Besteiro, S., Bhatia-Kissova, I., Bi, X., Biard-Piechaczyk, M., Espert, L., Blum, J. S., Boise, L. H., Lonial, S., Sun, S-Y., Bonaldo, P., Sandri, M., Boone, D. L., Bornhauser, B. C., Bourquin, J-P., Bortoluci, K. R., Bossis, I., Boya, P., Boyer-Guittaut, M., Bozhkov, P. V., Brady, N. R., Brancolini, C., Brech, A., Nezis, I. P., Rusten, T. E., Stenmark, H., Brenman, J. E., Brennand, A., Michels, P. A. M., Bresnick, E. H., Kang, Y-A., Brest, P., Hofman, P., Mograbi, B., Bristol, M. L., Gewirtz, D. A., Brookes, P. S., Johnson, G. V. W., Brown, E. J., Brumell, J. H., Huang, J., Kim, P. K., Brunk, U. T., Kurz, T., Bulman, D. E., Bultman, S. J., Bultynck, G., Parys, J. B., Burbulla, L. F., Krüger, R., Bursch, W., Butchar, J. P., Buzgariu, W., Galliot, B., Bydlowski, S. P., Cadwell, K., Cahová, M., Papackova, Z., Cai, D., Cai, J., Cai, Q., Calabretta, B., Sotgia, F., Calvo-Garrido, J., Escalante, R., Camougrand, N., Manon, S., Priault, M., Campanella, M., Campos-Salinas, J., Gonzalez-Rey, E., Oliver, F. J., Candi, E., Cao, L., Caplan, A. B., Carding, S. R., Cardoso, S. M., Moreira, P. I., Carew, J. S., Nawrocki, S. T., Carlin, C. R., Carmignac, V., Durbeej, M., Carneiro, L. A. M., Carra, S., Kampinga, H. H., Caruso, R. A., Casari, G., Casas, C., Castino, R., Isidoro, C., Cebollero, E., Reggiori, F., Cecconi, F., Ciriolo, M. R., Piacentini, M., Celli, J., Chaachouay, H., Rodemann, H. P., Chae, H-J., Chai, C-Y., Chan, D. C., Chan, E. Y., Coombs, G. H., Chang, R. C-C., Che, C-M., Lok, C-N., Sy, L-K., Chen, C-C., Lin, W-W., Chen, G-C., Yang, W. Y., Chen, G-Q., Chen, M., Wang, J., Chen, Q., Chen, S. S-L., Ke, P-Y., Lin, Y-L., Chen, W., Chen, Y-G., Liu, Y., Yu, L., Chen, Y., Guan, J-L., Towns, R., Wiley, J. W., Chen, Y-J., Chen, Z., Cheng, A., Cheng, C. H. K., Cheng, Y., Wang, H-G., Yang, J-M., El-Deiry, W. S., Cheong, H., Thompson, C. B., Cheong, J-H., Cherry, S., Chess-Williams, R., Cheung, Z. H., Chevet, E., Chiang, H-L., Chiba, T., Chin, L-S., Li, L., Mao, Z., Chiou, S-H., Cho, C. H., Cho, D-H., Choi, A. M. K., Haspel, J. A., Henske, E. P., Nakahira, K., Ryter, S. W., Choi, D., Choi, K. S., Choi, M. E., Münger, K., Chouaib, S., Choubey, D., Choubey, V., Kaasik, A., Chu, C. T., Rabinowich, H., Chuang, T-H., Chueh, S-H., Chun, T., Park, O. K., Chwae, Y-J., Chye, M-L., Ciarcia, R., Florio, S., Granato, G. E., Clague, M. J., Clark, R. S. B., Clarke, P. G. H., Puyal, J., Clarke, R., Saha, T., Codogno, P., Coller, H. A., Colombo, M. I., Comincini, S., Condorelli, F., Cookson, M. R., Coppens, I., Corbalan, R., Cossart, P., Costelli, P., Costes, S., Coto-Montes, A., Couve, E., Coxon, F. P., Helfrich, M. H., Hocking, L. J., Cregg, J. M., Crespo, J. L., Cronjé, M. J., Cuervo, A. M., Kaushik, S., Koga, H., Czaja, M. J., Cullen, J. J., D'Amelio, M., Darfeuille-Michaud, A., Davids, L. M., Davies, F. E., De Felici, M., De Groot, J. F., Fueyo, J., Gomez-Manzano, C., Jiang, H., De Haan, C. A. M., Monastyrska, I., De Martino, L., Fiorito, F., Iovane, V., Pagnini, U., De Milito, A., Joseph, B., Panaretakis, T., De Tata, V., Debnath, J., Degterev, A., Dehay, B., Delbridge, L. M. D., Demarchi, F., Schneider, C., Deng, Y. Z., Naqvi, N. I., Dengjel, J., Dent, P., Denton, D., Kumar, S., Deretic, V., Desai, S. D., Devenish, R. J., Mijaljica, D., Prescott, M., Ramm, G., Di Gioacchino, M., Di Paolo, G., Duff, K., Yu, W. H., Przedborski, S., Yamamoto, A., Di Pietro, C., Marazziti, D., Matteoni, R., Tocchini-Valentini, G., Díaz-Araya, G., Díaz-Laviada, I., Diaz-Meco, M. T., Fotedar, R., Hansen, M., Moscat, J., Reed, J. C., Salvesen, G., Yang, Z., Diaz-Nido, J., Izquierdo, M., Dinesh-Kumar, S. P., Ding, W-X., Distelhorst, C. W., Subauste, C. S., Wang, X., Zhu, X., Oleinick, N. L., Diwan, A., Djavaheri-Mergny, M., Dokudovskaya, S., Dong, Z., Willbold, D., Dorsey, F. C., Dosenko, V., Doxsey, S., Dreux, M., Duan, Q., Duchosal, M. A., Dugail, I., Kroemer, G., Maiuri, M. C., Duszenko, M., Edelstein, C. L., Edinger, A. L., Egea, G., Eichinger, L., Noegel, A. A., Eissa, N. T., Lin, W-C., Ekmekcioglu, S., Elazar, Z., Elgendy, M., Minucci, S., Ellerby, L. M., Er Eng, K., McInerney, G. M., Engelbrecht, A-M., Loos, B., Engelender, S., Erenpreisa, J., Eskelinen, E-L., Espina, V., Fan, H., Fan, J., Fan, Q-W., Ilkhanizadeh, S., Weiss, W. A., Fang, S., Monteiro, M. J., Fang, Y., Fanto, M., Farkas, T., Jäättelä, M., Farré, J-C., Nazarko, T. Y., Faure, M., Fechheimer, M., Furukawa, R. H., Feng, C. G., Feng, J., Feng, Q., Feng, Y., Fésüs, L., Feuer, R., Figueiredo-Pereira, M. E., Fimia, G. M., Fingar, D. C., Finkbeiner, S., Finkel, T., Finley, K. D., Gottlieb, R. A., Fisher, E. A., Fisher, P. B., Flajolet, M., Tian, Y., Florez-McClure, M. L., Fon, E. A., Fornai, F., Fortunato, F., Fox, H. S., Franco, R., Frankel, L. B., Lund, A. H., Fransen, M., Fuentes, J. M., González-Polo, R. A., Fujii, J., Fujisaki, K., Umemiya-Shirafuji, R., Fujita, E., Fukuda, M., Gaestel, M., Menon, M. B., Gailly, P., Gajewska, M., Motyl, T., Galy, V., Ganesh, S., Ganetzky, B., Ganley, I. G., Gao, F-B., Gao, G. F., Gao, J., Garcia, L., Lavandero, S., Garcia-Manero, G., Garcia-Marcos, M., Garmyn, M., Gartel, A. L., Gatti, E., Golstein, P., Pierre, P., Gautel, M., Gawriluk, T. R., Hale, A. N., Ledbetter, D. J., Rucker III, E. B., Gegg, M. E., Schapira, A. H. V., Geng, J., Harper, J. W., Germain, M., Slack, R. S., Lieberman, A., Lukacs, N. W., Ghavami, S., Halayko, A. J., Kirshenbaum, L. A., Yeganeh, B., Ghosh, P., Lee, J., Giammarioli, A. M., Malorni, W., Giatromanolaki, A. N., Sivridis, E., Gibson, S. B., Gilkerson, R. W., Sulzer, D., Ginger, M. L., Ginsberg, H. N., Tabas, I., Golab, J., Goligorsky, M. S., Goncu, E., Gongora, C., Le Cam, L., Pattingre, S., Gonzalez, C. D., Vaccaro, M. I., Gonzalez, R., González-Estévez, C., Gorbunov, N. V., Gorski, S., Goruppi, S., Gozuacik, D., Green, K. N., Gregorc, A., Gros, F., Muller, S., Grose, C., Grunt, T. W., Guan, K-L., Guichard, S. M., Gukovskaya, A. S., Gukovsky, I., Gunst, J., Van Den Berghe, G., Vanhorebeek, I., Gustafsson, A. B., Halonen, S. K., Hamasaki, M., Noda, T., Yoshimori, T., Han, F., Hancock, M. K., Harada, H., Harada, M., Hardt, S. E., Harris, A. L., Harris, J., Harris, S. D., Hashimoto, M., Hayashi, S-I., Hazelhurst, L. A., He, C., Levine, B., Terada, A. S., He, Y-W., Rathmell, J. C., Taylor, G. A., Hébert, M-J., Heidenreich, K. A., Helgason, G. V., Holyoake, T. L., Herman, B., Reiter, R. J., Herman, P. K., Hetz, C., Hilfiker, S., Navarro, M., Hill, J. A., Nemchenko, A., Yoshimoto, K., Hofmann, T. G., Höhfeld, J., Hong, M-H., Hood, D. A., Hotamisligil, G. S., Houwerzijl, E. J., Høyer-Hansen, M., Hu, B., Hu, C-A. 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    Research output: Contribution to journal › Article

  37. Human box C/D snoRNA processing conservation across multiple cell types

    Scott, M. S., Ono, M., Yamada, K., Endo, A., Barton, G. J. & Lamond, A. I. Apr-2012 In : Nucleic Acids Research. 40, 8, p. 3676-3688, 13 p.

    Research output: Contribution to journal › Article

  38. Modeling of the N-Glycosylated Transferrin Receptor Suggests How Transferrin Binding Can Occur within the Surface Coat of Trypanosoma brucei

    Mehlert, A., Wormald, M. R. & Ferguson, M. A. J. Apr-2012 In : PLoS Pathogens. 8, 4, p. -, 11 p., e1002618

    Research output: Contribution to journal › Article

  39. Regulation of the cardiac sodium pump

    Fuller, W., Tulloch, L. B., Howie, J., Wypijewski, K. J., Shattock, M. J. & Calaghan, S. C. Apr-2012 In : Cellular and Molecular Life Sciences. 70, 8, p. 1357-1380, 24 p.

    Research output: Contribution to journal › Article

  40. The de novo and salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-form Trypanosoma brucei

    Kuettel, S., Wadum, M. C. T., Guether, M. L. S., Marino, K., Riemer, C. & Ferguson, M. A. J. Apr-2012 In : Molecular Microbiology. 84, 2, p. 340-351, 12 p.

    Research output: Contribution to journal › Article

  41. Transcriptome analysis of skin reveals differences between atopic eczema cases stratified for filaggrin genotype

    Brown, S., Cole, C., Irvine, A., Barton, G. & McLean, I. Apr-2012 In : British Journal of Dermatology. 166, 4, p. e26-e27, 2 p., O-30

    Research output: Contribution to journal › Article

  42. Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction

    Buckley, D. L., Van Molle, I., Gareiss, P. C., Tae, H. S., Michel, J., Noblin, D. J., Jorgensen, W. L., Ciulli, A. & Crews, C. M. 14-Mar-2012 In : Journal of the American Chemical Society. 134, 10, p. 4465-4468, 4 p.

    Research output: Contribution to journal › Article

  43. A quantitative spatial proteomics analysis of proteome turnover in human cells

    Boisvert, F-M., Ahmad, Y., Gierlinski, M., Charrière, F., Lamont, D., Scott, M., Barton, G. & Lamond, A. I. 1-Mar-2012 In : Molecular & Cellular Proteomics. 11, 3

    Research output: Contribution to journal › Article

  44. Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness

    Abdelwahab, N. Z., Crossman, A. T., Sullivan, L., Ferguson, M. A. J. & Urbaniak, M. D. Mar-2012 In : Chemical Biology & Drug Design. 79, 3, p. 270-278, 9 p.

    Research output: Contribution to journal › Article

  45. Conserved signal peptide recognition systems across the prokaryotic domains

    Coulthurst, S. J., Dawson, A., Hunter, W. N. & Sargent, F. 28-Feb-2012 In : Biochemistry. 51, 8, p. 1678-1686, 9 p.

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  46. Synergy of peptide and sugar in O-GlcNAcase substrate recognition

    Schimpl, M., Borodkin, V. S., Gray, L. J. & van Aalten, D. M. F. 24-Feb-2012 In : Chemistry & Biology. 19, 2, p. 173-178, 6 p.

    Research output: Contribution to journal › Article

  47. Comparative proteomics profiling of a gentamicin-attenuated Leishmania infantum cell line identifies key changes in parasite thiol-redox metabolism

    Daneshvar, H., Wyllie, S., Phillips, S., Hagan, P. & Burchmore, R. 16-Feb-2012 In : Journal of Proteomics. 75, 5, p. 1463-1471, 9 p.

    Research output: Contribution to journal › Article

  48. Identification and localisation of the NB-LRR gene family within the potato genome

    Jupe, F., Pritchard, L., Etherington, G. J., MacKenzie, K., Cock, P. J. A., Wright, F., Sharma, S. K., Bolser, D., Bryan, G. J., Jones, J. D. G. & Hein, I. 15-Feb-2012 In : BMC Genomics. 13, p. -, 14 p., 75

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  49. Quinol derivatives as potential trypanocidal agents

    Capes, A., Patterson, S., Wyllie, S., Hallyburton, I., Collie, I. T., McCarroll, A. J., Stevens, M. F. G., Frearson, J. A., Wyatt, P. G., Fairlamb, A. H. & Gilbert, I. H. 15-Feb-2012 In : Bioorganic & Medicinal Chemistry. 20, 4, p. 1607-1615, 9 p.

    Research output: Contribution to journal › Article

  50. Infectious disease: Genomics decodes drug action

    Fairlamb, A. H. 9-Feb-2012 In : Nature. 482, 7384, p. 167-169, 3 p.

    Research output: Contribution to journal › Editorial

  51. Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

    Hjerpe, R., Thomas, Y., Chen, J., Zemla, A., Curran, S., Shpiro, N., Dick, L. R. & Kurz, T. 1-Feb-2012 In : Biochemical Journal. 441, p. 927-936, 10 p.

    Research output: Contribution to journal › Article

  52. The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis

    Wyllie, S., Patterson, S., Stojanovski, L., Simeons, F. R. C., Norval, S., Kime, R., Read, K. D. & Fairlamb, A. H. 1-Feb-2012 In : Science Translational Medicine. 4, 119, p. -, 7 p., 119re1

    Research output: Contribution to journal › Article

  53. Biosensor-Based Approach to the Identification of Protein Kinase Ligands with Dual-Site Modes of Action

    Navratilova, I., Macdonald, G., Robinson, C., Hughes, S., Mathias, J., Phillips, C. & Cook, A. Feb-2012 In : Journal of Biomolecular Screening. 17, 2, p. 183-193, 11 p.

    Research output: Contribution to journal › Article

  54. Quantifying the chemical beauty of drugs

    Bickerton, G. R., Paolini, G. V., Besnard, J., Muresan, S. & Hopkins, A. L. Feb-2012 In : Nature Chemistry. 4, 2, p. 90-98, 9 p.

    Research output: Contribution to journal › Article

  55. The crystal structure of Leishmania major N-5,N-10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target

    Eadsforth, T. C., Cameron, S. & Hunter, W. N. Feb-2012 In : Molecular and Biochemical Parasitology. 181, 2, p. 178-185, 8 p.

    Research output: Contribution to journal › Article

  56. Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

    Brand, S., Cleghorn, L. A. T., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Read, K. D., Wyatt, P. G. & Gilbert, I. H. 12-Jan-2012 In : Journal of Medicinal Chemistry. 55, 1, p. 140-152, 13 p.

    Research output: Contribution to journal › Article

  57. The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces

    Wong, E., Vaaje-Kolstad, G., Ghosh, A., Hurtado-Guerrero, R., Konarev, P. V., Ibrahim, A. F. M., Svergun, D. I., Eijsink, V. G. H., Chatterjee, N. S. & van Aalten, D. M. F. 12-Jan-2012 In : PLoS Pathogens. 8, 1, e1002373

    Research output: Contribution to journal › Article

  58. Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

    Spinks, D., Torrie, L. S., Thompson, S., Harrison, J. R., Frearson, J. A., Read, K. D., Fairlamb, A. H., Wyatt, P. G. & Gilbert, I. H. 2-Jan-2012 In : ChemMedChem. 7, 1, p. 95-106, 12 p.

    Research output: Contribution to journal › Article

  59. A comparative study of the CYP450 inhibition potential of marketed drugs using two fluorescence based assay platforms routinely used in the pharmaceutical industry

    Kajbaf, M., Longhi, R., Montanari, D., Vinco, F., Rigo, M., Fontano, S. & Read, K. D. 2012 In : Drug Metabolism Letters. 5, 1, p. 30-39, 10 p.

    Research output: Contribution to journal › Article

  60. Allosteric Competitive Inhibitors of the Glucose-1-phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa

    Alphey, M. S., Pirrie, L., Torrie, L. S., Boulkeroua, W. A., Gardiner, M., Sarkar, A., Maringer, M., Oehlmann, W., Brenk, R., Scherman, M. S., McNeil, M., Rejzek, M., Field, R. A., Singh, M., Gray, D., Westwood, N. J. & Naismith, J. H. 2012 In : ACS Chemical Biology.

    Research output: Contribution to journal › Article

  61. Assessment of pseudomonas aeruginosa N-5,N-10-methylenetetrahydrofolate dehydrogenase - cyclohydrolase as a potential antibacterial drug target

    Eadsforth, T. C., Gardiner, M., Maluf, F. V., McElroy, S., James, D., Frearson, J., Gray, D. & Hunter, W. N. 2012 In : PLoS ONE. 7, 4, p. -, 11 p., e35973

    Research output: Contribution to journal › Article

  62. Avirulence protein 3a (AVR3a) from the potato pathogen Phytophthora infestans forms homodimers through its predicted translocation region and does not specifically bind phospholipids

    Wawra, S., Agacan, M., Boddey, J. A., Davidson, I., Gachon, C. M. M., Zanda, M., Grouffaud, S., Whisson, S. C., Birch, P. R. J., Porter, A. J. & Van West, P. 2012 In : Journal of Biological Chemistry. 287, 45, p. 38101-38109, 9 p.

    Research output: Contribution to journal › Article

  63. BioJava: an open-source framework for bioinformatics in 2012

    Prlic, A., Yates, A., Bliven, S. E., Rose, P. W., Jacobsen, J., Troshin, P. V., Chapman, M., Gao, J., Koh, C. H., Foisy, S., Holland, R., Rimsa, G., Heuer, M. L., Brandstaetter-Mueller, H., Bourne, P. E. & Willis, S. 2012 In : Bioinformatics. 28, 20, p. 2693-2695, 3 p.

    Research output: Contribution to journal › Article

  64. Change or be changed: reflections of the workshop 'Future in Medicinal Chemistry'

    Brenk, R. & Rauh, D. 2012 In : Bioorganic & Medicinal Chemistry. 20, 12, p. 3695-3697, 3 p.

    Research output: Contribution to journal › Article

  65. Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo

    Wishart, T. M., Rooney, T. M., Lamont, D. J., Wright, A. K., Morton, A. J., Jackson, M., Freeman, M. R. & Gillingwater, T. H. 2012 In : PLoS Genetics. 8, 8

    Research output: Contribution to journal › Article

  66. Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages

    Urbaniak, M. D., Guther, M. L. S. & Ferguson, M. A. J. 2012 In : PLoS ONE. 7, 5, p. -, 8 p., e36619

    Research output: Contribution to journal › Article

  67. Direct sequencing of Arabidopsis thaliana RNA reveals patterns of cleavage and polyadenylation

    Sherstnev, A., Duc, C., Cole, C., Zacharaki, V., Hornyik, C., Ozsolak, F., Milos, P. M., Barton, G. J. & Simpson, G. G. 2012 In : Nature Structural & Molecular Biology.

    Research output: Contribution to journal › Article

  68. Genetic diversity in European Pisum germplasm collections

    Jing, R., Ambrose, M. A., Knox, M. R., Smykal, P., Hybl, M., Ramos, A., Caminero, C., Burstin, J., Duc, G., van Soest, L. J. M., Swiecicki, W. K., Pereira, M. G., Vishnyakova, M., Davenport, G. F., Flavell, A. J. & Ellis, T. H. N. 2012 In : Theoretical and Applied Genetics. 125, 2, p. 367-380, 14 p.

    Research output: Contribution to journal › Article

  69. Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide- binding properties

    Schimpl, M., Rush, C. L., Betou, M., Eggleston, I. M., Recklies, A. D. & van Aalten, D. M. F. 2012 In : Biochemical Journal. 446, 1, p. 149-157, 9 p.

    Research output: Contribution to journal › Article

  70. IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening

    Tidten-Luksch, N., Grimaldi, R., Torrie, L. S., Frearson, J. A., Hunter, W. N. & Brenk, R. 2012 In : PLoS ONE. 7, 4, p. -, 16 p., e35792

    Research output: Contribution to journal › Article

  71. Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation

    Fyfe, P. K., Westrop, G. D., Silva, A. M., Coombs, G. H. & Hunter, W. N. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 29, p. 11693-11698, 6 p.

    Research output: Contribution to journal › Article

  72. Live imaging of nascent RNA dynamics reveals distinct types of transcriptional pulse regulation

    Muramoto, T., Cannon, D., Gierlinski, M., Corrigan, A., Barton, G. J. & Chubb, J. R. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 19, p. 7350-7355, 6 p.

    Research output: Contribution to journal › Article

  73. MSK1 regulates homeostatic and experience-dependent synaptic plasticity

    Corrêa, S. A. L., Hunter, C. J., Palygin, O., Wauters, S. C., Martin, K. J., McKenzie, C., McKelvey, K., Morris, R. G. M., Pankratov, Y., Arthur, J. S. C. & Frenguelli, B. 2012 In : Journal of Neuroscience. 32, 38, p. 13039-13051, 13 p.

    Research output: Contribution to journal › Article

  74. O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

    Schimpl, M., Zheng, X., Borodkin, V. S., Blair, D. E., Ferenbach, A. T., Schüttelkopf, A. W., Navratilova, I., Aristotelous, T., Albarbarawi, O., Robinson, D. A., van Aalten, D. M. F. & Macnaughtan, M. A. 2012 In : Nature Chemical Biology.

    Research output: Contribution to journal › Article

  75. Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase

    Bandini, G., Marino, K., Güther, M. L. S., Wernimont, A. K., Kuettel, S., Qiu, W., Afzal, S., Kelner, A., Hui, R. & Ferguson, M. A. J. 2012 In : Molecular Microbiology. 85, 3, p. 513-534, 22 p.

    Research output: Contribution to journal › Article

  76. PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

    Tibarewal, P., Zilidis, G., Spinelli, L., Schurch, N., Maccario, H., Gray, A., Perera, N. M., Davidson, L., Barton, G. J. & Leslie, N. R. 2012 In : Science Signaling. 5, 213, p. ra18

    Research output: Contribution to journal › Article

  77. Purification, crystallization and preliminary X-ray diffraction data of UDP-galactopyranose mutase from Aspergillus fumigatus

    Penman, G. A., Lockhart, D. E. A., Ferenbach, A. & Van Aalten, D. M. F. 2012 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 68, 6, p. 705-708, 4 p.

    Research output: Contribution to journal › Article

  78. Structural and biochemical characterization of a trapped coenzyme a adduct of Caenorhabditis elegans glucosamine-6-phosphate N-acetyltransferase 1

    Dorfmueller, H. C., Fang, W., Rao, F. V., Blair, D. E., Attrill, H. & van Aalten, D. M. F. 2012 In : Acta Crystallographica Section D: Biological Crystallography. 68, 8, p. 1019-1029, 11 p.

    Research output: Contribution to journal › Article

  79. Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

    Cui, H., Carrero-Lérida, J., Silva, A. P. G., Whittingham, J. L., Brannigan, J. A., Ruiz-Pérez, L. M., Read, K. D., Wilson, K. S., González-Pacanowska, D. & Gilbert, I. H. 2012 In : Journal of Medicinal Chemistry. 55, 24, p. 10948-57, 10 p.

    Research output: Contribution to journal › Article

  80. Synthesis of novel tetrazole C5-linked C0- and C2-ribonucleoside phosphoramidites using MePOM and POM groups for probing RNA catalysis

    Harusawa, S., Yoneyama, H., Fujisue, D., Nishiura, M., Fujitake, M., Usami, Y., Zhao, Z., Mcphee, S. A., Wilson, T. J. & Lilley, D. M. J. 2012 In : Tetrahedron Letters. 53, 44, p. 5891-5894, 4 p.

    Research output: Contribution to journal › Article

  81. The kinomes of apicomplexan parasites

    Miranda-Saavedra, D., Gabaldón, T., Barton, G. J., Langsley, G. & Doerig, C. 2012 In : Microbes and Infection. 14, 10, p. 796-810, 15 p.

    Research output: Contribution to journal › Article

  82. The structure and folding of helical junctions in RNA

    Lilley, D. M. J. 2012 Innovations in Biomolecular Modeling and Simulations. Schlick, T. (ed.). Cambridge: Royal Society of Chemistry, (RSC Biomolecular Sciences).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

  83. The structure and folding of kink turns in RNA

    Lilley, D. M. J. 2012 In : Wiley Interdisciplinary Reviews: RNA. 3, 6, p. 797-805, 9 p.

    Research output: Contribution to journal › Article

  84. Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems

    Nelson, S. A., Li, Z., Newton, I. P., Fraser, D., Milne, R. E., Martin, D. M. A., Schiffmann, D., Yang, X., Dormann, D., Weijer, C. J., Appleton, P. L. & Nathke, I. S. 2012 In : Disease Models & Mechanisms.

    Research output: Contribution to journal › Article

  85. Whole organism high-content screening by label-free, image-based bayesian classification for parasitic diseases

    Paveley, R. A., Mansour, N. R., Hallyburton, I., Bleicher, L. S., Benn, A. E., Mikic, I., Guidi, A., Gilbert, I. H., Hopkins, A. L. & Bickle, Q. D. 2012 In : PLoS Neglected Tropical Diseases. 6, 7, e1762

    Research output: Contribution to journal › Article

  86. Investigation of copper(II) tetrafluoroborate catalysed epoxide opening

    Capes, A. S., Crossman, A. T., Webster, L. A., Ferguson, M. A. J. & Gilbert, I. H. 28-Dec-2011 In : Tetrahedron Letters. 52, 52, p. 7091-7094, 4 p.

    Research output: Contribution to journal › Article

  87. Protein O-GlcNAcylation is required for fibroblast growth factor signaling in Drosophila

    Mariappa, D., Sauert, K., Marino, K., Turnock, D., Webster, R., van Aalten, D. M. F., Ferguson, M. A. J. & Muller, H. A. J. 20-Dec-2011 In : Science Signaling. 4, 204, p. -, 8 p., ra89

    Research output: Contribution to journal › Article

  88. Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

    Cleghorn, L. A. T., Woodland, A., Collie, I. T., Torrie, L. S., Norcross, N., Luksch, T., Mpamhanga, C., Walker, R. G., Mottram, J. C., Brenk, R., Frearson, J. A., Gilbert, I. H. & Wyatt, P. G. 9-Dec-2011 In : ChemMedChem. 6, 12, p. 2214-2224, 11 p.

    Research output: Contribution to journal › Article

  89. Syringyl lignin is unaltered by severe sinapyl alcohol dehydrogenase suppression in tobacco

    Barakate, A., Stephens, J., Goldie, A., Hunter, W. N., Marshall, D., Hancock, R. D., Lapierre, C., Morreele, K., Boerjane, W. & Halpin, C. Dec-2011 In : Plant Cell. 23, 12, p. 4492-4506, 15 p.

    Research output: Contribution to journal › Article

  90. The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system

    Rao, V. A., Shepherd, S. M., English, G., Coulthurst, S. J. & Hunter, W. N. Dec-2011 In : Acta Crystallographica Section D: Biological Crystallography. 67, p. 1065-1072, 8 p.

    Research output: Contribution to journal › Article

  91. Chemical structure of Trichomonas vaginalis surface lipoglycan: a role for short galactose (beta 1-4/3) N-acetylglucosamine repeats in host cell interaction

    Ryan, C. M., Mehlert, A., Richardson, J. M., Ferguson, M. A. J. & Johnson, P. J. 25-Nov-2011 In : Journal of Biological Chemistry. 286, 47, p. 40494-40508, 15 p.

    Research output: Contribution to journal › Article

  92. From snoRNA to miRNA: Dual function regulatory non-coding RNAs

    Scott, M. S. & Ono, M. 1-Nov-2011 In : Biochimie. 93, 11, p. 1987-1992, 6 p.

    Research output: Contribution to journal › Article

  93. DrugPred: A Structure-Based Approach To Predict Protein Druggability Developed Using an Extensive Nonredundant Data Set

    Krasowski, A., Muthas, D., Sarkar, A., Schmitt, S. & Brenk, R. Nov-2011 In : Journal of Chemical Information and Modeling. 51, 11, p. 2829-2842, 14 p.

    Research output: Contribution to journal › Article

  94. Cell migration modulating compounds

    Schor, A. M., Schor, S. L., Marquez, R. & Norman, D. G. 19-Oct-2011 EP1917012

    Research output: Patent

  95. Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

    Patterson, S., Alphey, M. S., Jones, D. C., Shanks, E. J., Street, I. P., Frearson, J. A., Wyatt, P. G., Gilbert, I. H. & Fairlamb, A. H. 13-Oct-2011 In : Journal of Medicinal Chemistry. 54, 19, p. 6514-6530, 17 p.

    Research output: Contribution to journal › Article

  96. Design, Synthesis, and Evaluation of 5 '-Diphenyl Nucleoside Analogues as Inhibitors of the Plasmodium falciparum dUTPase

    Hampton, S. E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Alexander Musso-Buendia, J., Recio, E., Kaiser, M., Whittingham, J. L., Roberts, S. M., Shevtsov, M., Brannigan, J. A., Kahnberg, P., Brun, R., Wilson, K. S., Gonzalez-Pacanowska, D., Johansson, N. G. & Gilbert, I. H. 4-Oct-2011 In : ChemMedChem. 6, 10, p. 1816-1831, 16 p.

    Research output: Contribution to journal › Article

  97. Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

    Smith, V. C., Cleghorn, L. A. T., Woodland, A., Spinks, D., Hallyburton, I., Collie, I. T., Mok, N. Y., Norval, S., Brenk, R., Fairlamb, A. H., Frearson, J. A., Read, K. D., Gilbert, I. H. & Wyatt, P. G. 4-Oct-2011 In : ChemMedChem. 6, 10, p. 1832-1840, 9 p.

    Research output: Contribution to journal › Article

  98. Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery

    Philpott, M., Yang, J., Tumber, T., Fedorov, O., Uttarkar, S., Filippakopoulos, P., Picaud, S., Keates, T., Felletar, I., Ciulli, A., Knapp, S. & Heightman, T. D. 1-Oct-2011 In : Molecular BioSystems. 7, 10, p. 2899-2908, 10 p.

    Research output: Contribution to journal › Article

  99. Drug discovery initiative at the University of Dundee: hit-to-lead development for hat and generation of chemical tools

    Grimaldi, R., Urich, R., Sienkiewicz, N., Woodland, A., Urbaniak, M. D., Mathieson, T., Eberhard, D., Bantscheff, M., Drewes, G., Ferguson, M. A. J., Gilbert, I. H., Frearson, J. A., Wyatt, P. G. & Fairlamb, A. H. Oct-2011 In : Tropical Medicine & International Health. 16, Supp. 1, p. 212-212, 1 p.

    Research output: Contribution to journal › Meeting abstract

  100. Emerging role of surface plasmon resonance in fragment-based drug discovery

    Navratilova, I. & Hopkins, A. L. Oct-2011 In : Future Medicinal Chemistry. 3, 14, p. 1809-1820, 12 p.

    Research output: Contribution to journal › Scientific review

  101. Mining the ChEMBL Database: An Efficient Chemoinformatics Workflow for Assembling an Ion Channel-Focused Screening Library

    Mok, N. Y. & Brenk, R. Oct-2011 In : Journal of Chemical Information and Modeling. 51, 10, p. 2449-2454, 6 p.

    Research output: Contribution to journal › Article

  102. On the hunt for new diagnostic antigens for human African trypanosomiasis

    Sullivan, L., Carrington, M. & Ferguson, M. A. J. Oct-2011 In : Tropical Medicine & International Health. 16, p. 201-201, 1 p.

    Research output: Contribution to journal › Meeting abstract

  103. Probing the Dynamic Nature of Water Molecules and Their Influences on Ligand Binding in a Model Binding Site

    Cappel, D., Wahlstroem, R., Brenk, R. & Sotriffer, C. A. Oct-2011 In : Journal of Chemical Information and Modeling. 51, 10, p. 2581-2594, 14 p.

    Research output: Contribution to journal › Article

  104. Visceral leishmaniasis and arsenic: an ancient poison contributing to antimonial treatment failure in the Indian subcontinent?

    Perry, M., Wyllie, S., Prajapati, V. K., Feldmann, J., Sundar, S., Boelaert, M. & Fairlamb, A. H. Oct-2011 In : Tropical Medicine & International Health. 16, S1, p. 66-67, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  105. A role for Snf2-related nucleosome-spacing enzymes in genome-wide nucleosome organization

    Gkikopoulos, T., Schofield, P., Singh, V., Pinskaya, M., Mellor, J., Smolle, M., Workman, J. L., Barton, G. J. & Owen-Hughes, T. 23-Sep-2011 In : Science. 333, 6050, p. 1758-1760, 3 p.

    Research output: Contribution to journal › Article

  106. Pseudomonas aeruginosa 4-Amino-4-deoxychorismate lyase: spatial conservation of an active site tyrosine and classification of two types of enzyme

    O'Rourke, P. E. F., Eadsforth, T. C., Fyfe, P. K., Shepherd, S. M. & Hunter, W. N. 15-Sep-2011 In : PLoS ONE. 6, 9, p. -, 8 p., e24158

    Research output: Contribution to journal › Article

  107. RNA Tertiary Interactions in a Riboswitch Stabilize the Structure of a Kink Turn

    Schroeder, K. T., Daldrop, P. & Lilley, D. M. J. 7-Sep-2011 In : Structure. 19, 9, p. 1233-1240, 8 p.

    Research output: Contribution to journal › Article

  108. Computational approaches to selecting and optimising targets for structural biology

    Overton, I. M. & Barton, G. J. Sep-2011 In : Journal of Neuroscience Methods. 55, 1, p. 311, 9 p.

    Research output: Contribution to journal › Article

  109. Mechanism of ubiquitylation by dimeric RING ligase RNF4

    Plechanovova, A., Jaffray, E. G., McMahon, S. A., Johnson, K. A., Navratilova, I., Naismith, J. H. & Hay, R. T. Sep-2011 In : Nature Structural & Molecular Biology. 18, 9, p. 1052-U115, 9 p.

    Research output: Contribution to journal › Article

  110. Minimum information about a bioactive entity (MIABE)

    Orchard, S. , Al-Lazikani, B. , Bryant, S. , Clark, D. , Calder, E. , Dix, I. , Engkvist, O. , Forster, M. , Gaulton, A. , Gilson, M. , Glen, R. , Grigorov, M. , Hammond-Kosack, K. , Harland, L. , Hopkins, A. , Larminie, C. , Lynch, N. , Mann, R. K. , Murray-Rust, P. , Lo Piparo, E. & 6 others Southan, C., Steinbeck, C., Wishart, D., Hermjakob, H., Overington, J. & Thornton, J. Sep-2011 In : Nature Reviews Drug Discovery. 10, 9, p. 661-669, 9 p.

    Research output: Contribution to journal › Scientific review

  111. Visceral Leishmaniasis and Arsenic: An Ancient Poison Contributing to Antimonial Treatment Failure in the Indian Subcontinent?

    Perry, M. R., Wyllie, S., Prajapati, V. K., Feldmann, J., Sundar, S., Boelaert, M. & Fairlamb, A. H. Sep-2011 In : PLoS Neglected Tropical Diseases. 5, 9, p. -, 5 p., e1227

    Research output: Contribution to journal › Editorial

  112. PChopper: high throughput peptide prediction for MRM/SRM transition design

    Afzal, V., Huang, J. T-J., Atrih, A. & Crowther, D. J. 15-Aug-2011 In : BMC Bioinformatics. 12, p. -, 9 p., 338

    Research output: Contribution to journal › Article

  113. NoD: a Nucleolar localization sequence detector for eukaryotic and viral proteins

    Scott, M. S., Troshin, P. V. & Barton, G. J. 3-Aug-2011 In : BMC Bioinformatics. 12, p. -, 7 p., 317

    Research output: Contribution to journal › Article

  114. Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites

    Hunter, W. N. Aug-2011 In : Current Topics in Medicinal Chemistry. 11, 16, p. 2048-2059, 12 p.

    Research output: Contribution to journal › Scientific review

  115. Regulation of Caenorhabditis elegans p53/CEP-1-Dependent Germ Cell Apoptosis by Ras/MAPK Signaling

    Rutkowski, R., Dickinson, R., Stewart, G., Craig, A., Schimpl, M., Keyse, S. M. & Gartner, A. Aug-2011 In : PLoS Genetics. 7, 8, p. -, 21 p., e1002238

    Research output: Contribution to journal › Article

  116. The impact of dedicated dermatology services on the awareness of cutaneous cancer risk and on attitudes towards UV exposure among transplant recipients

    Casabonne, D., Newton, R., Ismail, F., Mitchell, L., Lally, A., Imko-Walczuk, B., Wojnarowska, F., Proby, C. & Harwood, C. Aug-2011 In : Journal of Epidemiology and Community Health. 65, p. A107-A107, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  117. Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database

    Bickerton, G. R., Higueruelo, A. P. & Blundell, T. L. 29-Jul-2011 In : BMC Bioinformatics. 12, p. -, 14 p., 313

    Research output: Contribution to journal › Article

  118. Java bioinformatics analysis web services for multiple sequence alignment-JABAWS:MSA

    Troshin, P. V., Procter, J. B. & Barton, G. J. 15-Jul-2011 In : BMC Bioinformatics. 27, 14, p. 2001-2002, 2 p.

    Research output: Contribution to journal › Article

  119. The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains

    Ryan, D. P., Sundaramoorthy, R., Martin, D., Singh, V. & Owen-Hughes, T. 6-Jul-2011 In : EMBO Journal. 30, 13, p. 2596-2609, 14 p.

    Research output: Contribution to journal › Article

  120. Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei

    Marino, K., Guther, M. L. S., Wernimont, A. K., Qiu, W., Hui, R. & Ferguson, M. A. J. Jul-2011 In : Eukaryotic Cell. 10, 7, p. 985-997, 13 p.

    Research output: Contribution to journal › Article

  121. Screening for GPCR Ligands Using Surface Plasmon Resonance

    Hopkins Navratilova, I., Besnard, J. & Hopkins, A. L. Jul-2011 In : ACS Medicinal Chemistry Letters. 2, 7, p. 549-554, 6 p.

    Research output: Contribution to journal › Article

  122. Synthetic Neoglycoconjugates of Cell-Surface Phosphoglycans of Leishmania as Potential Anti-parasite Carbohydrate Vaccines

    Nikolaev, A. V. & Sizova, O. V. Jul-2011 In : Biochemistry-Moscow. 76, 7, p. 761-773, 13 p.

    Research output: Contribution to journal › Scientific review

  123. The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential for novel treatments for schizophrenia

    Large, C. H., Bison, S., Sartori, I., Read, K. D., Gozzi, A., Quarta, D., Antolini, M., Hollands, E., Gill, C. H., Gunthorpe, M. J., Idris, N., Neill, J. C. & Alvaro, G. S. Jul-2011 In : Journal of Pharmacology and Experimental Therapeutics. 338, 1, p. 100-113, 14 p.

    Research output: Contribution to journal › Article

  124. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis

    Dias, M. V. B., Snee, W. C., Bromfield, K. M., Payne, R. J., Palaninathan, S. K., Ciulli, A., Howard, N. I., Abell, C., Sacchettini, J. C. & Blundell, T. L. 15-Jun-2011 In : Biochemical Journal. 436, 3, p. 729-739, 11 p.

    Research output: Contribution to journal › Article

  125. Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

    Dow, G. S. , Milner, E. , Bathurst, I. , Bhonsle, J. , Caridha, D. , Gardner, S. , Gerena, L. , Kozar, M. , Lanteri, C. , Mannila, A. , McCalmont, W. , Moon, J. , Read, K. D. , Norval, S. , Roncal, N. , Shackleford, D. M. , Sousa, J. , Steuten, J. , White, K. L. , Zeng, Q. & 1 others Charman, S. A. 6-Jun-2011 In : Malaria Journal. 10, p. -, 11 p., 150

    Research output: Contribution to journal › Article

  126. Antimicrobial drug discovery

    Fairlamb, A. & Cole, S. Jun-2011 In : Future Microbiology. 6, 6, p. 601-602, 2 p.

    Research output: Contribution to journal › Editorial

  127. Bisdionin C-A rationally designed, submicromolar inhibitor of family 18 chitinases

    Schuettelkopf, A. W., Andersen, O. A., Rao, F. V., Allwood, M., Rush, C. L., Eggleston, I. M. & van Aalten, D. M. F. Jun-2011 In : ACS Medicinal Chemistry Letters. 2, 6, p. 428-432, 5 p.

    Research output: Contribution to journal › Article

  128. Probing Elongating and Branching beta-D-Galactosyltransferase Activities in Leishmania Parasites by Making Use of Synthetic Phosphoglycans

    Sizova, O. V., Ross, A. J., Ivanova, I. A., Borodkin, V. S., Ferguson, M. A. J. & Nikolaev, A. V. Jun-2011 In : ACS Chemical Biology. 6, 6, p. 648-657, 10 p.

    Research output: Contribution to journal › Article

  129. Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor

    Sutherland, T. E., Andersen, O. A., Betou, M., Eggleston, I. M., Maizels, R. M., van Aalten, D. & Allen, J. E. 27-May-2011 In : Chemistry & Biology. 18, 5, p. 569-579, 11 p.

    Research output: Contribution to journal › Article

  130. Design of molecules

    Hopkins, A. & Besnard, J. 26-May-2011 PCT/GB2010/051940

    Research output: Patent

  131. The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4

    Gkikopoulos, T., Singh, V., Tsui, K., Awad, S., Renshaw, M. J., Scholfield, P., Barton, G. J., Nislow, C., Tanaka, T. U. & Owen-Hughes, T. 18-May-2011 In : EMBO Journal. 30, 10, p. 1919-1927, 9 p.

    Research output: Contribution to journal › Article

  132. A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation

    Sugden, C., Ross, S., Annesley, S. J., Cole, C., Bloomfield, G., Ivens, A., Skelton, J., Fisher, P. R., Barton, G. & Williams, J. G. 15-May-2011 In : Developmental Biology. 353, 2, p. 290-301, 12 p.

    Research output: Contribution to journal › Article

  133. Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus

    Overton, I. M., Graham, S., Gould, K. A., Hinds, J., Botting, C. H., Shirran, S., Barton, G. J. & Coote, P. J. 12-May-2011 In : BMC Systems Biology. 5, p. -, 16 p., 68

    Research output: Contribution to journal › Article

  134. Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate

    Morgan, R. E., Batot, G. O., Dement, J. M., Rao, V. A., Eadsforth, T. C. & Hunter, W. N. 9-May-2011 In : BMC Structural Biology. 11, p. -, 9 p., 21

    Research output: Contribution to journal › Article

  135. MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

    Filippi, B. M., de los Heros, P., Mehellou, Y., Navratilova, I., Gourlay, R., Deak, M., Plater, L., Toth, R., Zeqiraj, E. & Alessi, D. R. 4-May-2011 In : EMBO Journal. 30, 9, p. 1730-1741, 12 p.

    Research output: Contribution to journal › Article

  136. Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei

    Abdelwahab, N. Z., Urbaniak, M. D., Ferguson, M. A. J. & Crossman, A. T. 1-May-2011 In : Carbohydrate Research. 346, 6, p. 708-714, 7 p.

    Research output: Contribution to journal › Article

  137. Finding New Hits in Neglected Disease Projects: Target or Phenotypic Based Screening?

    Gilbert, I. H., Leroy, D. & Frearson, J. A. May-2011 In : Current Topics in Medicinal Chemistry. 11, 10, p. 1284-1291, 8 p.

    Research output: Contribution to journal › Scientific review

  138. Identification of human miRNA precursors that resemble box C/D snoRNAs

    Ono, M., Scott, M. S., Yamada, K., Avolio, F., Barton, G. J. & Lamond, A. I. May-2011 In : Nucleic Acids Research. 39, 9, p. 3879-3891, 13 p.

    Research output: Contribution to journal › Article

  139. Methylglyoxal metabolism in trypanosomes and leishmania

    Wyllie, S. & Fairlamb, A. H. May-2011 In : Seminars in Cell & Developmental Biology. 22, 3, p. 271-277, 7 p.

    Research output: Contribution to journal › Scientific review

  140. Progress in Neglected Disease Drug Discovery

    Hopkins, A. L. & Wyatt, P. G. May-2011 In : Current Topics in Medicinal Chemistry. 11, 10, p. 1215-1215, 1 p.

    Research output: Contribution to journal › Editorial

  141. Rapid Analysis of Pharmacology for Infectious Diseases

    Hopkins, A. L., Bickerton, G. R., Carruthers, I. M., Boyer, S. K., Rubin, H. & Overington, J. P. May-2011 In : Current Topics in Medicinal Chemistry. 11, 10, p. 1292-1300, 9 p.

    Research output: Contribution to journal › Scientific review

  142. Target Validation: Linking Target and Chemical Properties to Desired Product Profile

    Wyatt, P. G., Gilbert, I. H., Read, K. D. & Fairlamb, A. H. May-2011 In : Current Topics in Medicinal Chemistry. 11, 10, p. 1275-1283, 9 p.

    Research output: Contribution to journal › Scientific review

  143. Exploiting the high-resolution crystal structure of Staphylococcus aureus MenH to gain insight into enzyme activity

    Dawson, A., Fyfe, P. K., Gillet, F. & Hunter, W. N. 22-Apr-2011 In : BMC Structural Biology. 11, p. -, 11 p., 19

    Research output: Contribution to journal › Article

  144. Evaluation of three novel azasterols against Toxoplasma gondii

    Martins-Duarte, É. S., Lemgruber, L., de Souza, W., Vommaro, R. C., Lorente, S. O., Gros, L., Magaraci, F. & Gilbert, I. H. 19-Apr-2011 In : Veterinary Parasitology. 177, 1-2, p. 157-161, 5 p.

    Research output: Contribution to journal › Article

  145. beta-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase

    Baragana, B., McCarthy, O., Sanchez, P., Bosch-Navarrete, C., Kaiser, M., Brun, R., Whittingham, J. L., Roberts, S. M., Zhou, X-X., Wilson, K. S., Johansson, N. G., Gonzalez-Pacanowska, D. & Gilbert, I. H. 1-Apr-2011 In : Bioorganic & Medicinal Chemistry. 19, 7, p. 2378-2391, 14 p.

    Research output: Contribution to journal › Article

  146. Developing small molecule drugs to rescue nonsense mutations in disease-causing genes

    Nomura, T., Gartner, U., McElroy, S., Torrie, L., Pourreyron, C., South, A. P., Wood, G., Woodland, A., Frearson, J., Wyatt, P. & McLean, I. Apr-2011 In : Journal of Investigative Dermatology. 131, p. S67-S67, 1 p., 397

    Research output: Contribution to journal › Book/Film/Article review

  147. The role of Co2+in the crystallization of human SENP1 and comments on the limitations of automated refinement protocols

    Rimsa, V., Eadsforth, T. & Hunter, W. N. Apr-2011 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 67, p. 442-445, 4 p.

    Research output: Contribution to journal › Article

  148. XANNpred: Neural nets that predict the propensity of a protein to yield diffraction-quality crystals

    Overton, I. M., van Niekerk, C. A. J. & Barton, G. J. Apr-2011 In : Proteins: Structure, Function, and Bioinformatics. 79, 4, p. 1027-1033, 7 p.

    Research output: Contribution to journal › Article

  149. Effect of PI3K-and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKBI-deficient mice

    Garcia-Martinez, J. M., Wullschleger, S., Preston, G., Guichard, S., Fleming, S., Alessi, D. R. & Duce, S. L. 29-Mar-2011 In : British Journal of Cancer. 104, 7, p. 1116-1125, 10 p.

    Research output: Contribution to journal › Article

  150. Dissecting the Metabolic Roles of Pteridine Reductase 1 in Trypanosoma brucei and Leishmania major

    Ong, H. B., Sienkiewicz, N., Wyllie, S. & Fairlamb, A. H. 25-Mar-2011 In : Journal of Biological Chemistry. 286, 12, p. 10429-10438, 10 p.

    Research output: Contribution to journal › Article

  151. Novel Ligands for a Purine Riboswitch Discovered by RNA-Ligand Docking

    Daldrop, P., Reyes, F. E., Robinson, D. A., Hammond, C. M., Lilley, D. M., Batey, R. T. & Brenk, R. 25-Mar-2011 In : Chemistry & Biology. 18, 3, p. 324-335, 12 p.

    Research output: Contribution to journal › Article

  152. Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism

    Konig, J., Wyllie, S., Wells, G., Stevens, M. F., Wyatt, P. G. & Fairlamb, A. H. 11-Mar-2011 In : Journal of Biological Chemistry. 286, 10, p. 8523-8533, 11 p.

    Research output: Contribution to journal › Article

  153. Multiwall carbon nanotubes as MRI contrast agents for tracking stem cells

    Vittorio, O., Duce, S. L., Pietrabissa, A. & Cuschieri, A. 4-Mar-2011 In : Nanotechnology. 22, 9, p. -, 7 p., 095706

    Research output: Contribution to journal › Article

  154. Molecular recognition: O-GlcNAc transfer: size matters

    Gay, L. M., Zheng, X. & van Aalten, D. M. F. Mar-2011 In : Nature Chemical Biology. 7, 3, p. 134-135, 3 p.

    Research output: Contribution to journal › Comment/debate

  155. Substrate and product analogues as human O-GlcNAc transferase inhibitors

    Dorfmueller, H. C., Borodkin, V. S., Blair, D. E., Pathak, S., Navratilova, I. & van Aalten, D. M. F. Mar-2011 In : Amino Acids. 40, 3, p. 781-792, 12 p.

    Research output: Contribution to journal › Article

  156. Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

    Spinks, D., Ong, H. B., Mpamhanga, C. P., Shanks, E. J., Robinson, D. A., Collie, I. T., Read, K. D., Frearson, J. A., Wyatt, P. G., Brenk, R., Fairlamb, A. H. & Gilbert, I. H. 7-Feb-2011 In : ChemMedChem. 6, 2, p. 302-308, 7 p.

    Research output: Contribution to journal › Article

  157. Modified 5'-trityl nucleosides as inhibitors of plasmodium falciparum dUTPase

    Gilbert, I. H., Ruda, G. F., Nguyen, C., Kasinathan, G., Ziemkowski, P., Felczak, K., Kulikowski, T., Musso-Buendia, A., Ruiz-Pérez, L. M., González-Pacanowska, D., Sund, C., Zhou, X. X., Johansson, N. G., Kaiser, M. & Brun, R. 7-Feb-2011 In : ChemMedChem. 6, 2, p. 309-320, 12 p.

    Research output: Contribution to journal › Article

  158. Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase

    Walton, J. G. A., Jones, D. C., Kiuru, P., Durie, A. J., Westwood, N. J. & Fairlamb, A. H. 7-Feb-2011 In : ChemMedChem. 6, 2, p. 321-328, 8 p.

    Research output: Contribution to journal › Article

  159. PNAC: a protein nucleolar association classifier

    Scott, M. S., Boisvert, F-M., Lamond, A. I. & Barton, G. J. 27-Jan-2011 In : BMC Genomics. 12, p. -, 14 p., 74

    Research output: Contribution to journal › Article

  160. Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms

    Sainsbury, S., Bird, L., Rao, V., Shepherd, S. M., Stuart, D. I., Hunter, W. N., Owens, R. J. & Ren, J. 7-Jan-2011 In : Journal of Molecular Biology. 405, 1, p. 173-184, 12 p.

    Research output: Contribution to journal › Article

  161. PIMS sequencing extension: a laboratory information management system for DNA sequencing facilities

    Troshin, P. V., Barton, G. J., Postis, V. L., Baldwin, S. A., Ashworth, D. & McPherson, M. J. 1-Jan-2011 In : BMC Research Notes. 4, 48, 48

    Research output: Contribution to journal › Article

  162. How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance

    Wullschleger, S., Sakamoto, K., Johnstone, L., Duce, S., Fleming, S. & Alessi, D. R. Jan-2011 In : Disease Models & Mechanisms. 4, 1, p. 95-103, 9 p.

    Research output: Contribution to journal › Article

  163. Micro-magnetic resonance imaging study of live quail embryos during embryonic development

    Duce, S., Morrison, F., Tickle, C., Welten, M. & Baggott, G. Jan-2011 In : Magnetic Resonance Imaging. 29, 1, p. 132-139, 8 p.

    Research output: Contribution to journal › Article

  164. Structure of recombinant Leishmania donovani pteridine reductase reveals a disordered active site

    Barrack, K. L., Tulloch, L. B., Burke, L-A., Fyfe, P. K. & Hunter, W. N. Jan-2011 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 67, p. 33-37, 5 p.

    Research output: Contribution to journal › Article

  165. Triclosan is minimally effective in rodent malaria models

    Baschong, W., Wittlin, S., Inglis, K. A., Fairlamb, A. H., Croft, S. L., Kumar, T. R. S., Fidock, D. A. & Brun, R. Jan-2011 In : Nature Medicine. 17, 1, p. 33-34, 2 p.

    Research output: Contribution to journal › Letter

  166. Characterization of in vivo metabolites of WR319691, a novel compound with activity against Plasmodium falciparum

    Milner, E., Sousa, J., Pybus, B., Melendez, V., Gardner, S., Grauer, K., Moon, J., Carroll, D., Auschwitz, J., Gettayacamin, M., Lee, P., Leed, S., McCalmont, W., Norval, S., Tungtaeng, A., Zeng, Q., Kozar, M., Read, K. D., Li, Q. & Dow, G. 2011 In : European Journal of Drug Metabolism and Pharmacokinetics. 36, 3, p. 151-158, 8 p.

    Research output: Contribution to journal › Article

  167. Comparison of the specificity of Trk inhibitors in recombinant and neuronal assays

    Martin, K. J., Shpiro, N., Traynor, R., Elliott, M. & Arthur, J. S. C. 2011 In : Neuropharmacology. 61, 1-2, p. 148-155, 8 p.

    Research output: Contribution to journal › Article

  168. Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPase

    Recio, E., Musso-Buendía, A., Vidal, A. E., Ruda, G. F., Kasinathan, G., Nguyen, C., Ruiz-Pérez, L. M., Gilbert, I. H. & González-Pacanowska, D. 2011 In : European Journal of Medicinal Chemistry. 46, 8, p. 3309-3314, 6 p.

    Research output: Contribution to journal › Article

  169. Synthetic glycosylphosphatidylinositol (GPI) anchors: how these complex molecules have been made

    Nikolaev, A. V. & Al-Maharik, N. 2011 In : Natural Product Reports. 28, 5, p. 970-1020, 51 p.

    Research output: Contribution to journal › Scientific review

  170. Acetazolamide-based fungal chitinase inhibitors

    Schuettelkopf, A. W., Gros, L., Blair, D. E., Frearson, J. A., van Aalten, D. M. F. & Gilbert, I. H. 1-Dec-2010 In : Bioorganic & Medicinal Chemistry. 18, 23, p. 8334-8340, 7 p.

    Research output: Contribution to journal › Article

  171. Crystal structure of Leishmania major ADP-ribosylation factor-like 1 and a classification of related GTPase family members in this Kinetoplastid

    Fleming, J. R., Dawson, A. & Hunter, W. N. Dec-2010 In : Molecular and Biochemical Parasitology. 174, 2, p. 141-144, 4 p.

    Research output: Contribution to journal › Article

  172. High-resolution structures of Trypanosoma brucei pteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug target

    Dawson, A., Tulloch, L. B., Barrack, K. L. & Hunter, W. N. Dec-2010 In : Acta Crystallographica Section D: Biological Crystallography. 66, p. 1334-1340, 7 p.

    Research output: Contribution to journal › Article

  173. Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase

    Marino, K., Guther, M. L. S., Wernimont, A. K., Amani, M., Hui, R. & Ferguson, M. A. J. Dec-2010 In : Glycobiology. 20, 12, p. 1619-1630, 12 p.

    Research output: Contribution to journal › Article

  174. Pseudokinases-remnants of evolution or key allosteric regulators?

    Zeqiraj, E. & van Aalten, D. M. F. Dec-2010 In : Current Opinion in Structural Biology. 20, 6, p. 772-781, 10 p.

    Research output: Contribution to journal › Article

  175. Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases

    Dorfmueller, H. C., Borodkin, V. S., Schimpl, M., Zheng, X., Kime, R., Read, K. D. & van Aalten, D. M. F. 24-Nov-2010 In : Chemistry & Biology. 17, 11, p. 1250-1255, 6 p.

    Research output: Contribution to journal › Article

  176. Human OGA binds substrates in a conserved peptide recognition groove

    Schimpl, M., Schuettelkopf, A. W., Borodkin, V. S. & van Aalten, D. M. F. 15-Nov-2010 In : Biochemical Journal. 432, p. 1-7, 7 p.

    Research output: Contribution to journal › Article

  177. Identification of a kappa-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

    Jones, D. C., Hallyburton, I., Stojanovski, L., Read, K. D., Frearson, J. A. & Fairlamb, A. H. 15-Nov-2010 In : Biochemical Pharmacology. 80, 10, p. 1478-1486, 9 p.

    Research output: Contribution to journal › Article

  178. Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

    McMahon, M., Lamont, D. J., Beattie, K. A. & Hayes, J. D. 2-Nov-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 44, p. 18838-18843, 6 p.

    Research output: Contribution to journal › Article

  179. High-resolution whole-genome sequencing reveals that specific Chromatin Domains from most human chromosomes associate with nucleoli

    van Koningsbruggen, S., Gierlinski, M., Schofield, P., Martin, D., Barton, G. J., Ariyurek, Y., den Dunnen, J. T. & Lamond, A. I. 1-Nov-2010 In : Molecular Biology of the Cell. 21, 21, p. 3735-3748, 14 p.

    Research output: Contribution to journal › Article

  180. A high-throughput in vitro screen to identify inhibitors of the trypanosoma brucei trypananthione synthethase activity

    Kramer, M., Torrie, L., Booker, M., Spinks, D., Barker, R. H., Oza, S., Harris, M., Frearson, J., Collie, I. & Fairlamb, A. Nov-2010 In : American Journal of Tropical Medicine and Hygiene. 83, 5 (Suppl.), p. 323-323, 1 p., 1083

    Research output: Contribution to journal › Book/Film/Article review

  181. Central nervous system (CNS) exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous (IV) dosing in mice

    Dow, G. S., Milner, E., Caridha, D., Gardner, S., Lanteri, C., Kozar, M., Mannila, A., McCalmont, W., Melendez, V., Moon, J., Read, K., Norval, S., Roncal, N., Shackleford, D., Sousa, J., Stouten, J., White, K., Zeng, Q. & Charman, S. Nov-2010 p. 213-213 1 p.

    Research output: Contribution to conference › Abstract

  182. Characterization and prediction of protein nucleolar localization sequences

    Scott, M. S., Boisvert, F-M., McDowall, M. D., Lamond, A. I. & Barton, G. J. Nov-2010 In : Nucleic Acids Research. 38, 21, p. 7388-7399, 12 p.

    Research output: Contribution to journal › Article

  183. Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase

    Cui, H., Ruda, G. F., Carrero-Lerida, J., Ruiz-Perez, L. M., Gilbert, I. H. & Gonzalez-Pacanowska, D. Nov-2010 In : European Journal of Medicinal Chemistry. 45, 11, p. 5140-5149, 10 p.

    Research output: Contribution to journal › Article

  184. Glycoinositolphosphorylceramide from Pathogenic Fungus Sporothrix schenckii Shows That Fatty Acid Hydroxylation Level Correlates with the Mycelium-Yeast Thermal-Induced Morphological Transition

    Medeiros, A., Bandini, G., Macedo, C., Ferguson, M., Kirsch, S., Soltwisch, J., Previato, J., Mendonca-Previato, L. & Peter-Katalinic, J. Nov-2010 In : Glycobiology. 20, 11, p. 1506-1506, 1 p.

    Research output: Contribution to journal › Meeting abstract

  185. Glycotyping of Trypanosoma brucei variant surface glycoprotein MITat1.8

    Mehlert, A., Sullivan, L. & Ferguson, M. A. J. Nov-2010 In : Molecular and Biochemical Parasitology. 174, 1, p. 74-77, 4 p.

    Research output: Contribution to journal › Article

  186. O-Glcnacase substrate recognition involves both sugar and protein

    Schimpl, M., Schuettelkopf, A., Borodkin, V. S. & Van Aalten, D. M. F. Nov-2010 In : Glycobiology. 20, 11, p. 1481-1481, 1 p., 101

    Research output: Contribution to journal › Book/Film/Article review

  187. O-Glcnacylation of TAB1 modulates TAK1-mediated cytokine release

    Pathak, S., Campbell, D., Ibrahim, A. & Van Aalten, D. M. F. Nov-2010 In : Glycobiology. 20, 11, p. 1478-1478, 1 p., 92

    Research output: Contribution to journal › Book/Film/Article review

  188. Engineered biocompatible nanoparticles for in vivo imaging applications

    Chen, S., Wang, L., Duce, S. L., Brown, S., Lee, S., Melzer, A., Cuschieri, A. & Andre, P. 27-Oct-2010 In : Journal of the American Chemical Society. 132, 42, p. 15022-15029, 8 p.

    Research output: Contribution to journal › Article

  189. Design and preparation of sterol mimetics as potential antiparasitics

    Gigante, F., Kaiser, M., Brun, R. & Gilbert, I. H. 15-Oct-2010 In : Bioorganic & Medicinal Chemistry. 18, 20, p. 7291-7301, 11 p.

    Research output: Contribution to journal › Article

  190. Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum

    Cui, H., Ruiz-Perez, L. M., Gonzalez-Pacanowska, D. & Gilbert, I. H. 15-Oct-2010 In : Bioorganic & Medicinal Chemistry. 18, 20, p. 7302-7309, 8 p.

    Research output: Contribution to journal › Article

  191. Drug discovery in academia: the third way?

    Frearson, J. & Wyatt, P. Oct-2010 In : Expert Opinion on Drug Discovery. 5, 10, p. 909-919, 11 p.

    Research output: Contribution to journal › Scientific review

  192. Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates

    Wyllie, S., Mandal, G., Singh, N., Sundar, S., Fairlamb, A. H. & Chatterjee, M. Oct-2010 In : Molecular and Biochemical Parasitology. 173, 2, p. 162-164, 3 p.

    Research output: Contribution to journal › Article

  193. Prophossi: automating expert validation of phosphopeptide-spectrum matches from tandem mass spectrometry

    Martin, D. M. A., Nett, I. R. E., Vandermoere, F., Barber, J. D., Morrice, N. A. & Ferguson, M. A. J. 1-Sep-2010 In : Bioinformatics. 26, 17, p. 2153-2159, 7 p.

    Research output: Contribution to journal › Article

  194. Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds

    Ruda, G. F., Wong, P. E., Alibu, V. P., Norval, S., Read, K. D., Barrett, M. P. & Gilbert, I. H. 26-Aug-2010 In : Journal of Medicinal Chemistry. 53, 16, p. 6071-6078, 8 p.

    Research output: Contribution to journal › Article

  195. Structure and reactivity of Bacillus subtilis MenD catalyzing the first committed step in menaquinone biosynthesis

    Dawson, A., Chen, M., Fyfe, P. K., Guo, Z. & Hunter, W. N. 13-Aug-2010 In : Journal of Molecular Biology. 401, 2, p. 253-264, 12 p.

    Research output: Contribution to journal › Article

  196. Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif

    Klee, N., Wong, P. E., Baragana, B., El Mazouni, F., Phillips, M. A., Barrett, M. P. & Gilbert, I. H. 1-Aug-2010 In : Bioorganic & Medicinal Chemistry Letters. 20, 15, p. 4364-4366, 3 p.

    Research output: Contribution to journal › Article

  197. Potentiation of the anticonvulsant efficacy of sodium channel inhibitors by an NK1-receptor antagonist in the rat

    Kalinichev, M., Bradford, A., Bison, S., Lucas, A., Sartori, I., Garbati, N., Andreetta, F., Bate, S., Austin, N. E., Jones, D. N. C., Read, K. D., Alvaro, G. & Large, C. H. Aug-2010 In : Epilepsia. 51, 8, p. 1543-1551, 9 p.

    Research output: Contribution to journal › Article

  198. Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery

    Fyfe, P. K., Dawson, A., Hutchison, M-T., Cameron, S. & Hunter, W. N. Aug-2010 In : Acta Crystallographica Section D: Biological Crystallography. 66, p. 881-888, 8 p.

    Research output: Contribution to journal › Article

  199. Structure of the three-way helical junction of the hepatitis C virus IRES element

    Ouellet, J., Melcher, S., Iqbal, A., Ding, Y. & Lilley, D. M. J. Aug-2010 In : RNA: a Publication of the RNA Society. 16, 8, p. 1597-1609, 13 p.

    Research output: Contribution to journal › Article

  200. Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice

    Sienkiewicz, N., Ong, H. B. & Fairlamb, A. H. Aug-2010 In : Molecular Microbiology. 77, 3, p. 658-671, 14 p.

    Research output: Contribution to journal › Article

  201. Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase

    Ruda, G. F., Campbell, G., Alibu, V. P., Barrett, M. P., Brenk, R. & Gilbert, I. H. 15-Jul-2010 In : Bioorganic & Medicinal Chemistry. 18, 14, p. 5056-5062, 7 p.

    Research output: Contribution to journal › Article

  202. 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor

    Micheli, F. , Cavanni, P. , Andreotti, D. , Arban, R. , Benedetti, R. , Bertani, B. , Bettati, M. , Bettelini, L. , Bonanomi, G. , Braggio, S. , Carletti, R. , Checchia, A. , Corsi, M. , Fazzolari, E. , Fontana, S. , Marchioro, C. , Merlo-Pich, E. , Negri, M. , Oliosi, B. , Ratti, E. & 11 others Read, K. D., Roscic, M., Sartori, I., Spada, S., Tedesco, G., Tarsi, L., Terreni, S., Visentini, F., Zocchi, A., Zonzini, L. & Di Fabio, R. 8-Jul-2010 In : Journal of Medicinal Chemistry. 53, 13, p. 4989-5001, 13 p.

    Research output: Contribution to journal › Article

  203. Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4 '-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness

    Durrant, J. D., Urbaniak, M. D., Ferguson, M. A. J. & McCammon, J. A. 8-Jul-2010 In : Journal of Medicinal Chemistry. 53, 13, p. 5025-5032, 8 p.

    Research output: Contribution to journal › Article

  204. A fluorescence lifetime-based assay for serine and threonine kinases that is suitable for high-throughput screening

    Paterson, M. J., Dunsmore, C. J., Hurteaux, R., Maltman, B. A., Cotton, G. J. & Gray, A. 1-Jul-2010 In : Analytical Biochemistry. 402, 1, p. 54-64, 11 p.

    Research output: Contribution to journal › Article

  205. Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis

    Sokolova, A. Y., Wyllie, S., Patterson, S., Oza, S. L., Read, K. D. & Fairlamb, A. H. Jul-2010 In : Antimicrobial Agents and Chemotherapy. 54, 7, p. 2893-2900, 8 p.

    Research output: Contribution to journal › Article

  206. Know your chemical space

    Hopkins, A. L. & Bickerton, G. R. Jul-2010 In : Nature Chemical Biology. 6, 7, p. 482-483, 2 p.

    Research output: Contribution to journal › Comment/debate

  207. Structural basis for the efficient phosphorylation of AZT-MP (3 '-azido-3 '-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

    Whittingham, J. L., Carrero-Lerida, J., Brannigan, J. A., Ruiz-Perez, L. M., Silva, A. P. G., Fogg, M. J., Wilkinson, A. J., Gilbert, I. H., Wilson, K. S. & Gonzalez-Pacanowska, D. 15-Jun-2010 In : Biochemical Journal. 428, p. 499-509, 11 p.

    Research output: Contribution to journal › Article

  208. Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors

    Wang, S. , Midgley, C. A. , Scaërou, F. , Grabarek, J. B. , Griffiths, G. , Jackson, W. , Kontopidis, G. , McClue, S. J. , McInnes, C. , Meades, C. , Mezna, M. , Plater, A. , Stuart, I. , Thomas, M. P. , Wood, G. , Clarke, R. G. , Blake, D. G. , Zheleva, D. I. , Lane, D. P. , Jackson, R. C. & 2 others Glover, D. M. & Fischer, P. M. 10-Jun-2010 In : Journal of Medicinal Chemistry. 53, 11, p. 4367-4378, 12 p.

    Research output: Contribution to journal › Article

  209. Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins

    Remenyi, J., Hunter, C. J., Cole, C., Ando, H., Impey, S., Monk, C. E., Martin, K. J., Barton, G. J., Hutvagner, G. & Arthur, J. S. C. 1-Jun-2010 In : Biochemical Journal. 428, p. 281-291, 11 p.

    Research output: Contribution to journal › Article

  210. Nucleophilic catalysis of acylhydrazone equilibration for protein-directed dynamic covalent chemistry

    Bhat, V. T., Caniard, A. M., Luksch, T., Brenk, R., Campopiano, D. J. & Greaney, M. F. Jun-2010 In : Nature Chemistry. 2, 6, p. 490-497, 8 p.

    Research output: Contribution to journal › Article

  211. Nuclear DBF-2-related Kinases Are Essential Regulators of Cytokinesis in Bloodstream Stage Trypanosoma brucei

    Ma, J., Benz, C., Grimaldi, R., Stockdale, C., Wyatt, P., Frearson, J. & Hammarton, T. C. 14-May-2010 In : Journal of Biological Chemistry. 285, 20, p. 15356-15368, 13 p.

    Research output: Contribution to journal › Article

  212. Analysis of Human Small Nucleolar RNAs (snoRNA) and the Development of snoRNA Modulator of Gene Expression Vectors

    Ono, M., Yamada, K., Avolio, F., Scott, M. S., van Koningsbruggen, S., Barton, G. J. & Lamond, A. I. 1-May-2010 In : Molecular Biology of the Cell. 21, 9, p. 1569-1584, 16 p.

    Research output: Contribution to journal › Article

  213. Application of electrospray mass spectrometry to the structural determination of glycosylphosphatidylinositol membrane anchors

    Nett, I. R. E., Mehlert, A., Lamont, D. & Ferguson, M. A. J. May-2010 In : Glycobiology. 20, 5, p. 576-585, 10 p.

    Research output: Contribution to journal › Article

  214. Optimization of the interligand Overhauser effect for fragment linking: Application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase

    Sledz, P., Silvestre, H. L., Hung, A. W., Ciulli, A., Blundell, T. L. & Abell, C. 7-Apr-2010 In : Journal of the American Chemical Society. 132, 13, p. 4544-4545, 2 p.

    Research output: Contribution to journal › Article

  215. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

    van Aalten, D. M. F. , Gilbert, I. H. & 24 others Frearson, J. A., Brand, S., McElroy, S. P., Cleghorn, L. A. T., Smid, O., Stojanovski, L., Price, H. P., Guther, M. L. S., Torrie, L. S., Robinson, D. A., Hallyburton, I., Mpamhanga, C. P., Brannigan, J. A., Wilkinson, A. J., Hodgkinson, M., Hui, R., Qiu, W., Raimi, O. G., Brenk, R., Read, K. D., Fairlamb, A. H., Ferguson, M. A. J., Smith, D. F. & Wyatt, P. G. 1-Apr-2010 In : Nature. 464, 7289, p. 728-732, 7 p.

    Research output: Contribution to journal › Article

  216. Fragment Screening by Surface Plasmon Resonance

    Hopkins Navratilova, I. & Hopkins, A. L. Apr-2010 In : ACS Medicinal Chemistry Letters. 1, 1, p. 44-48, 5 p.

    Research output: Contribution to journal › Article

  217. Regulation of plant gene expression by alternative splicing

    Simpson, C. G., Manthri, S., Raczynska, K. D., Kalyna, M., Lewandowska, D., Kusenda, B., Maronova, M., Szweykowska-Kulinska, Z., Jarmolowski, A., Barta, A. & Brown, J. W. S. Apr-2010 In : Biochemical Society Transactions. 38, 2, p. 667-671, 5 p.

    Research output: Contribution to journal › Article

  218. Shotgun Proteomics in the discovery of biomarkers of non-alcoholic fatty liver disease: an improved methodology

    Miller, M., Jafferbhoy, H., Ferguson, M. A. J. & Dillon, J. Apr-2010 In : Gut. 59, S1, p. A104-A104, 1 p.

    Research output: Contribution to journal › Special issue

  219. Structure of Trypanosoma brucei glutathione synthetase: domain and loop alterations in the catalytic cycle of a highly conserved enzyme

    Fyfe, P. K., Alphey, M. S. & Hunter, W. N. Apr-2010 In : Molecular and Biochemical Parasitology. 170, 2, p. 93-99, 7 p.

    Research output: Contribution to journal › Article

  220. The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist

    Rimland, J., Dunne, A., Hunjan, S. S., Sasse, R., Uings, I., Montanari, D., Caivano, M., Shah, P., Standing, D., Gray, D., Brown, D., Cairns, W., Trump, R., Smith, P. W., Bertheleme, N., D'Alessandro, P., Gul, S., Vimal, M., Smith, D. N. & Watson, S. P. Apr-2010 In : Bioorganic & Medicinal Chemistry Letters. 20, 7, p. 2340-3, 4 p.

    Research output: Contribution to journal › Article

  221. Water-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis

    Nicoletti, S., Seifert, K. & Gilbert, I. H. Apr-2010 In : Bioorganic & Medicinal Chemistry. 18, 7, p. 2559-2565, 7 p.

    Research output: Contribution to journal › Article

  222. 1-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors

    Micheli, F. , Cavanni, P. , Arban, R. , Benedetti, R. , Bertani, B. , Bettati, M. , Bettelini, L. , Bonanomi, G. , Braggio, S. , Checchia, A. , Davalli, S. , Di Fabio, R. , Fazzolari, E. , Fontana, S. , Marchioro, C. , Minick, D. , Negri, M. , Oliosi, B. , Read, K. D. , Sartori, I. & 6 others Tedesco, G., Tarsi, L., Terreni, S., Visentini, F., Zocchi, A. & Zonzini, L. 25-Mar-2010 In : Journal of Medicinal Chemistry. 53, 6, p. 2534-2551, 18 p.

    Research output: Contribution to journal › Article

  223. Erratum - a case-control study of cutaneous squamous cell carcinoma among Caucasian organ transplant recipients: The role of antibodies against human papillomavirus and other risk factors (vol 125, pg 1935, 2009)

    Casabonne, D., Lally, A., Mitchell, L., Michael, K. M., Waterboer, T., Pawlita, M., Imko-Walczuk, B., Wojnarowska, F., Proby, C., Harwood, C. & Newton, R. 1-Mar-2010 In : International Journal of Cancer. 126, 5, p. 1282-1282, 1 p.

    Research output: Contribution to journal › Article

  224. Visualizing biological data: now and in the future

    O'Donoghue, S. I., Gavin, A-C., Gehlenborg, N., Goodsell, D. S., Hériché, J-K., Nielsen, C. B., North, C., Olson, A. J., Procter, J. B., Shattuck, D. W., Walter, T. & Wong, B. 1-Mar-2010 In : Nature Methods. 7, 3 SUPPL., p. S2-S4

    Research output: Contribution to journal › Article

  225. A triclinic crystal form of Escherichia coli 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure

    Kalinowska-Tluscik, J., Miallau, L., Gabrielsen, M., Leonard, G. A., McSweeney, S. M. & Hunter, W. N. Mar-2010 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 66, p. 237-241, 5 p.

    Research output: Contribution to journal › Article

  226. Assessing brain free fraction in early drug discovery

    Read, K. D. & Braggio, S. Mar-2010 In : Expert Opinion on Drug Metabolism & Toxicology. 6, 3, p. 337-344, 8 p.

    Research output: Contribution to journal › Scientific review

  227. Visualization of multiple alignments, phylogenies and gene family evolution

    Procter, J. B., Thompson, J., Letunic, I., Creevey, C., Jossinet, F. & Barton, G. J. Mar-2010 In : Nature Methods. 7, 3, p. S16-S25, 10 p.

    Research output: Contribution to journal › Scientific review

  228. Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds

    Dorfmueller, H. C. & van Aalten, D. M. F. 19-Feb-2010 In : FEBS Letters. 584, 4, p. 694-700, 7 p.

    Research output: Contribution to journal › Article

  229. The genetic diversity and evolution of field pea (Pisum) studied by high throughput retrotransposon based insertion polymorphism (RBIP) marker analysis

    Jing, R., Vershinin, A., Grzebyta, J., Shaw, P., Smykal, P., Marshall, D., Ambrose, M. J., Ellis, T. H. N. & Flavell, A. J. 15-Feb-2010 In : BMC Evolutionary Biology. 10, p. -, 20 p., 44

    Research output: Contribution to journal › Article

  230. Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

    Shanks, E. J., Ong, H. B., Robinson, D. A., Thompson, S., Sienkiewicz, N., Fairlamb, A. H. & Frearson, J. A. 15-Jan-2010 In : Analytical Biochemistry. 396, 2, p. 194-203, 10 p.

    Research output: Contribution to journal › Article

  231. Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the Leishmaniases

    Tulloch, L. B., Martini, V. P., Iulek, J., Huggan, J. K., Lee, J. H., Gibson, C. L., Smith, T. K., Suckling, C. J. & Hunter, W. N. 14-Jan-2010 In : Journal of Medicinal Chemistry. 53, 1, p. 221-229, 9 p.

    Research output: Contribution to journal › Article

  232. A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology

    Durrant, J. D., Amaro, R. E., Xie, L., Urbaniak, M. D., Ferguson, M. A. J., Haapalainen, A., Chen, Z., Di Guilmi, A. M., Wunder, F., Bourne, P. E. & McCammon, J. A. Jan-2010 In : PLoS Computational Biology. 6, 1, p. -, 8 p., e1000648

    Research output: Contribution to journal › Article

  233. Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T-cruzi

    Jones, D. C., Ariza, A., Chow, W-H. A., Oza, S. L. & Fairlamb, A. H. Jan-2010 In : Molecular and Biochemical Parasitology. 169, 1, p. 12-19, 8 p.

    Research output: Contribution to journal › Article

  234. Micro-magnetic resonance imaging and embryological analysis of wild-type and pma mutant mice with clubfoot

    Duce, S., Madrigal, L., Schmidt, K., Cunningham, C., Liu, G., Barker, S., Tennant, G., Tickle, C., Chudek, S. & Miedzybrodzka, Z. Jan-2010 In : Journal of Anatomy. 216, 1, p. 108-120, 13 p.

    Research output: Contribution to journal › Article

  235. Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects

    Price, H. P., Guther, M. L. S., Ferguson, M. A. J. & Smith, D. F. Jan-2010 In : Molecular and Biochemical Parasitology. 169, 1, p. 55-58, 4 p.

    Research output: Contribution to journal › Article

  236. The tetrahydrobiopterin pathway and pain

    Naylor, A. M., Pojasek, K. R., Hopkins, A. L. & Blagg, J. Jan-2010 In : Current Opinion in Investigational Drugs. 11, 1, p. 19-30, 12 p.

    Research output: Contribution to journal › Scientific review

  237. An ontology for description of drug discovery investigations

    Qi, D., King, R. D., Hopkins, A. L., Bickerton, G. R. J. & Soldatova, L. N. 2010 In : Journal of Integrative Bioinformatics. 7, 3

    Research output: Contribution to journal › Article

  238. On the synthesis of N-maleoyl amino acids in aqueous media: cautionary tales for the unwary traveller

    Paterson, M. J. & Jovanovic, A. 2010 In : ARKIVOC. p. 11-16, 6 p.

    Research output: Contribution to journal › Article

  239. The Scottish Structural Proteomics Facility: targets, methods and outputs

    Oke, M. , Carter, L. G. , Johnson, K. A. , Liu, H. , McMahon, S. A. , Yan, X. , Kerou, M. , Weikart, N. D. , Kadi, N. , Sheikh, M. A. , Schmelz, S. , Dorward, M. , Zawadzki, M. , Cozens, C. , Falconer, H. , Powers, H. , Overton, I. M. , van Niekerk, C. A. J. , Peng, X. , Patel, P. & 11 others Garrett, R. A., Prangishvili, D., Botting, C. H., Coote, P. J., Dryden, D. T. F., Barton, G. J., Schwarz-Linek, U., Challis, G. L., Taylor, G. L., White, M. F. & Naismith, J. H. 2010 In : Journal of Structural and Functional Genomics. 11, 2, p. 167-80, 14 p.

    Research output: Contribution to journal › Article

  240. Chemical Validation of Trypanothione Synthetase a potential drug targer for human trypanosomiasis

    Torrie, L. S., Wyllie, S., Spinks, D., Oza, S. L., Thompson, S., Harrison, J. R., Gilbert, I. H., Wyatt, P. G., Fairlamb, A. H. & Frearson, J. A. 25-Dec-2009 In : Journal of Biological Chemistry. 284, 52, p. 36137-36145, 9 p.

    Research output: Contribution to journal › Article

  241. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

    Zeqiraj, E., Filippi, B. M., Deak, M., Alessi, D. R. & van Aalten, D. M. F. 18-Dec-2009 In : Science. 326, 5960, p. 1707-1711, 5 p.

    Research output: Contribution to journal › Article

  242. Thiolactomycin analogues as potential anti-Toxoplasma gondii agents

    Martins-Duarte, E. S., de Souza, W., Vommaro, R. C., Jones, S. M., Gilbert, I. H. & Atella, G. C. 1-Dec-2009 In : Parasitology International. 58, 4, p. 411-415, 5 p.

    Research output: Contribution to journal › Article

  243. Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs

    Cole, C., Sobala, A., Lu, C., Thatcher, S. R., Bowman, A., Brown, J. W. S., Green, P. J., Barton, G. J. & Hutvagner, G. Dec-2009 In : RNA: a Publication of the RNA Society. 15, 12, p. 2147-2160, 14 p.

    Research output: Contribution to journal › Article

  244. HTS and hit finding in academia - from chemical genomics to drug discovery

    Frearson, J. A. & Collie, I. T. Dec-2009 In : Drug Discovery Today. 14, 23-24, p. 1150-1158, 9 p.

    Research output: Contribution to journal › Article

  245. Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

    Spinks, D., Shanks, E. J., Cleghorn, L. A. T., McElroy, S., Jones, D., James, D., Fairlamb, A. H., Frearson, J. A., Wyatt, P. G. & Gilbert, I. H. Dec-2009 In : ChemMedChem. 4, 12, p. 2060-2069, 10 p.

    Research output: Contribution to journal › Article

  246. A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry

    Scott, D. E., Dawes, G. J., Ando, M., Abell, C. & Ciulli, A. 23-Nov-2009 In : ChemBioChem. 10, 17, p. 2772-2779, 8 p.

    Research output: Contribution to journal › Article

  247. Drug discovery Predicting promiscuity

    Hopkins, A. L. 12-Nov-2009 In : Nature. 462, 7270, p. 167-168, 2 p.

    Research output: Contribution to journal › Editorial

  248. A requirement for GDP-L-fucose in Leishmania inferred by rescue of D-arabinopyranose/L-fucose salvage mutants (Fkp40(-)/Afkp80(-)) by expression of GDP-L-fuc synthetic enzymes

    Guo, H., Novozhilova, N. M., Bandini, G., Notton, T., Turco, S. J., Ferguson, M. A. J. & Beverley, S. M. Nov-2009 In : Glycobiology. 19, 11, p. 1297-1297, 1 p.

    Research output: Contribution to journal › Meeting abstract

  249. Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods

    Wyllie, S., Oza, S. L., Patterson, S., Spinks, D., Thompson, S. & Fairlamb, A. H. Nov-2009 In : Molecular Microbiology. 74, 3, p. 529-540, 12 p.

    Research output: Contribution to journal › Article

  250. Preferential Activation of TLR2/6 Heterodimer by Synthetic Trypanosoma Cruzi Trypomastigote Glycosylphosphatidylinositols is Enhanced by Coexpression of CD14 and CD36

    Nohara, L., Yashunsky, D., Ferguson, M., Nikolaev, A. & Almeida, I. Nov-2009 In : Glycobiology. 19, 11, p. 1361-1361, 1 p., 247

    Research output: Contribution to journal › Meeting abstract

  251. Proteomic scale high-sensitivity analyses of GPI membrane anchors

    Mehlert, A. & Ferguson, M. A. J. Nov-2009 In : Glycoconjugate Journal. 26, 8, p. 915-921, 7 p.

    Research output: Contribution to journal › Article

  252. Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase

    Hung, A. W., Silvestre, H. L., Wen, S., Ciulli, A., Blundell, T. L. & Abell, C. 26-Oct-2009 In : Angewandte Chemie International Edition. 48, 45, p. 8452-8456, 5 p.

    Research output: Contribution to journal › Article

  253. 1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein

    Kelleher, M. O., McMahon, M., Eggleston, I. M., Dixon, M. J., Taguchi, K., Yamamoto, M. & Hayes, J. D. Oct-2009 In : Carcinogenesis. 30, 10, p. 1754-1762, 9 p.

    Research output: Contribution to journal › Article

  254. The Orientation of a Tandem POTRA Domain Pair, of the Beta-Barrel Assembly Protein BamA, Determined by PELDOR Spectroscopy

    Ward, R., Zoltner, M., Beer, L., El Mkami, H., Henderson, I. R., Palmer, T. & Norman, D. G. 9-Sep-2009 In : Structure. 17, 9, p. 1187-1194, 8 p.

    Research output: Contribution to journal › Article

  255. ABC50 promotes translation initiation in mammalian cells

    Paytubi, S., Wang, X., Lam, Y. W., Izquierdo, L., Hunter, M. J., Jan, E., Hundal, H. S. & Proud, C. G. 4-Sep-2009 In : Journal of Biological Chemistry. 284, 36, p. 24061-24073, 13 p.

    Research output: Contribution to journal › Article

  256. Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases

    Izquierdo, L., Schulz, B. L., Rodrigues, J. A., Guther, M. L. S., Procter, J. B., Barton, G. J., Aebi, M. & Ferguson, M. A. J. 2-Sep-2009 In : EMBO Journal. 28, 17, p. 2650-2661, 12 p.

    Research output: Contribution to journal › Article

  257. Fate of Glycosylphosphatidylinositol (GPI)-Less Procyclin and Characterization of Sialylated Non-GPI-Anchored Surface Coat Molecules of Procyclic-Form Trypanosoma brucei

    Guether, M. L. S., Beattie, K., Lamont, D. J., James, J., Prescott, A. R. & Ferguson, M. A. J. Sep-2009 In : Eukaryotic Cell. 8, 9, p. 1407-1417, 11 p.

    Research output: Contribution to journal › Article

  258. Human miRNA Precursors with Box H/ACA snoRNA Features

    Scott, M. S., Avolio, F., Ono, M., Lamond, A. I. & Barton, G. J. Sep-2009 In : PLoS Computational Biology. 5, 9, p. -, 13 p., e1000507

    Research output: Contribution to journal › Article

  259. The emerging academic drug-discovery sector

    Wyatt, P. G. Sep-2009 In : Future Medicinal Chemistry. 1, 6, p. 1013-1017, 5 p.

    Research output: Contribution to journal › Editorial

  260. The ethanolamine branch of the Kennedy pathway is essential in the bloodstream form of Trypanosoma brucei

    Gibellini, F., Hunter, W. N. & Smith, T. K. Sep-2009 In : Molecular Microbiology. 73, 5, p. 826-843, 18 p.

    Research output: Contribution to journal › Article

  261. CARB 22-GPI anchors: WHY and HOW the complex molecules are being synthesized

    Nikolaev, A. V. 16-Aug-2009 In : Abstracts of Papers of the American Chemical Society. 238, p. -, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  262. Hit to lead and lead optimization of novel small molecules for the treatment of human African trypanosomiasis

    Freeman, J. C., Perales, J. B., Woodland, A., Bacchi, C. J., Bowling, T. S., Cleghorn, L., Gamon, C. G., Grimaldi, R., Hauser, D., Mercer, L. T., Nare, B., Nguyen, T. M., Noe, R. A., Rewerts, C. E., Wring, S. A., Wyatt, P. G., Yarlett, N. R., Jacobs, R. T. & Don, R. 16-Aug-2009 In : Abstracts of Papers of the American Chemical Society. 238, p. -, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  263. SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents

    Gigante, F., Kaiser, M., Brun, R. & Gilbert, I. H. 15-Aug-2009 In : Bioorganic & Medicinal Chemistry. 17, 16, p. 5950-5961, 12 p.

    Research output: Contribution to journal › Article

  264. Casein kinase 1 isoform 2 is essential for bloodstream form Trypanosoma brucei

    Urbaniak, M. D. Aug-2009 In : Molecular and Biochemical Parasitology. 166, 2, p. 183-185, 3 p.

    Research output: Contribution to journal › Article

  265. Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis

    Richardson, J. L., Nett, I. R. E., Jones, D. C., Abdille, M. H., Gilbert, I. H. & Fairlamb, A. H. Aug-2009 In : ChemMedChem. 4, 8, p. 1333-1340, 8 p.

    Research output: Contribution to journal › Article

  266. Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

    Patterson, S., Jones, D. C., Shanks, E. J., Frearson, J. A., Gilbert, I. H., Wyatt, P. G. & Fairlamb, A. H. Aug-2009 In : ChemMedChem. 4, 8, p. 1341-1353, 13 p.

    Research output: Contribution to journal › Article

  267. One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

    Mpamhanga, C. P., Spinks, D., Tulloch, L. B., Shanks, E. J., Robinson, D. A., Collie, I. T., Fairlamb, A. H., Wyatt, P. G., Frearson, J. A., Hunter, W. N., Gilbert, I. H. & Brenk, R. 23-Jul-2009 In : Journal of Medicinal Chemistry. 52, 14, p. 4454-4465, 12 p.

    Research output: Contribution to journal › Article

  268. Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

    Munoz, I. M., Hain, K., Declais, A-C., Gardiner, M., Toh, G. W., Sanchez-Pulido, L., Heuckmann, J. M., Toth, R., Macartney, T., Eppink, B., Kanaar, R., Ponting, C. P., Lilley, D. M. J. & Rouse, J. 10-Jul-2009 In : Molecular Cell. 35, 1, p. 116-127, 12 p.

    Research output: Contribution to journal › Article

  269. A crowdsourcing evaluation of the NIH chemical probes

    Oprea, T. I., Bologa, C. G., Boyer, S., Curpan, R. F., Glen, R. C., Hopkins, A. L., Lipinski, C. A., Marshall, G. R., Martin, Y. C., Ostopovici-Halip, L., Rishton, G., Ursu, O., Vaz, R. J., Waller, C., Waldmann, H. & Sklar, L. A. Jul-2009 In : Nature Chemical Biology. 5, 7, p. 441-447, 7 p.

    Research output: Contribution to journal › Article

  270. The phosphoproteome of bloodstream form Trypanosoma brucei, causative agent of African sleeping sickness

    Nett, I. R. E., Martin, D. M. A., Miranda-Saavedra, D., Lamont, D., Barber, J. D., Mehlert, A. & Ferguson, M. A. J. Jul-2009 In : Molecular & Cellular Proteomics. 8, 7, p. 1527-1538, 12 p.

    Research output: Contribution to journal › Article

  271. The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat

    Large, C. H., Kalinichev, M., Lucas, A., Carignani, C., Bradford, A., Garbati, N., Sartori, I., Austin, N. E., Ruffo, A., Jones, D. N. C., Alvaro, G. & Read, K. D. Jul-2009 In : Epilepsy Research. 85, 1, p. 96-106, 11 p.

    Research output: Contribution to journal › Article

  272. Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity

    Holloway, G. A., Charman, W. N., Fairlamb, A. H., Brun, R., Kaiser, M., Kostewicz, E., Novello, P. M., Parisot, J. P., Richardson, J., Street, I. P., Watson, K. G. & Baell, J. B. Jul-2009 In : Antimicrobial Agents and Chemotherapy. 53, 7, p. 2824-2833, 10 p.

    Research output: Contribution to journal › Article

  273. Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

    Higgins, L. G., Kelleher, M. O., Eggleston, I. M., Itoh, K., Yamamoto, M. & Hayes, J. D. 15-Jun-2009 In : Toxicology and Applied Pharmacology. 237, 3, p. 267-280, 14 p.

    Research output: Contribution to journal › Article

  274. GIcNAcstatins are nanomolar inhibitors of human O-GIcNAcase inducing cellular hyper-O-GIcNAcylation

    Dorfmueller, H. C., Borodkin, V. S., Schimpl, M. & van Aalten, D. M. F. 1-Jun-2009 In : Biochemical Journal. 420, p. 221-227, 7 p.

    Research output: Contribution to journal › Article

  275. ATP and MO25 alpha regulate the conformational state of the STRAD alpha pseudokinase and activation of the LKB1 tumour suppressor

    Zeqiraj, E., Filippi, B. M., Goldie, S., Navratilova, I., Boudeau, J., Deak, M., Alessi, D. R. & van Aalten, D. M. F. Jun-2009 In : PLoS Biology. 7, 6, p. -, 19 p., e1000126

    Research output: Contribution to journal › Article

  276. Structural and functional characterization of a putative polysaccharide deacetylase of the human parasite Encephalitozoon cuniculi

    Urch, J. E., Hurtado-Guerrero, R., Brosson, D., Liu, Z., Eijsink, V. G. H., Texier, C. & van Aalten, D. M. F. Jun-2009 In : Protein Science. 18, 6, p. 1197-1209, 13 p.

    Research output: Contribution to journal › Article

  277. System-wide changes to SUMO modifications in response to heat shock

    Golebiowski, F., Matic, I., Tatham, M. H., Cole, C., Yin, Y., Nakamura, A., Cox, J., Barton, G. J., Mann, M. & Hay, R. T. 26-May-2009 In : Science Signaling. 2, 72, p. -, 12 p., ra24

    Research output: Contribution to journal › Article

  278. Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb

    Schmidt, K., Hughes, C., Chudek, J. A., Goodyear, S. R., Aspden, R. M., Talbot, R., Gundersen, T. E., Blomhoff, R., Henderson, C., Wolf, C. R. & Tickle, C. 15-May-2009 In : Molecular and Cellular Biology. 29, 10, p. 2716-2729, 14 p.

    Research output: Contribution to journal › Article

  279. Jalview Version 2-a multiple sequence alignment editor and analysis workbench

    Waterhouse, A. M., Procter, J. B., Martin, D. M. A., Clamp, M. & Barton, G. J. 1-May-2009 In : BMC Bioinformatics. 25, 9, p. 1189-1191, 3 p.

    Research output: Contribution to journal › Article

  280. Structure-based ligand design and the promise held for antiprotozoan drug discovery

    Hunter, W. N. 1-May-2009 In : Journal of Biological Chemistry. 284, 18, p. 11749-11753, 5 p.

    Research output: Contribution to journal › Scientific review

  281. Geobacillus stearothermophilus 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate

    Cameron, S., Martini, V. P., Iulek, J. & Hunter, W. N. May-2009 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 65, p. 450-454, 5 p.

    Research output: Contribution to journal › Article

  282. N-(2-hydroxypropyl)methacrylamide-amphotericin B (HPMA-AmB) copolymer conjugates as antileishmanial agents

    Nicoletti, S., Seifert, K. & Gilbert, I. H. May-2009 In : International Journal of Antimicrobial Agents. 33, 5, p. 441-448, 8 p.

    Research output: Contribution to journal › Article

  283. A Structure-Based Approach to Ligand Discovery for 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase: A Target for Antimicrobial Therapy

    Ramsden, N. L., Buetow, L., Dawson, A., Kemp, L. A., Ulaganathan, V., Brenk, R., Klebe, G. & Hunter, W. N. 23-Apr-2009 In : Journal of Medicinal Chemistry. 52, 8, p. 2531-2542, 12 p.

    Research output: Contribution to journal › Article

  284. GPIomics: global analysis of glycosylphosphatidylinositol-anchored molecules of Trypanosoma cruzi

    Nakayasu, E. S., Yashunsky, D. V., Nohara, L. L., Torrecilhas, A. C. T., Nikolaev, A. V. & Almeida, I. C. Apr-2009 In : Molecular Systems Biology. 5, p. -, 17 p., 261

    Research output: Contribution to journal › Article

  285. Identification and specific localization of tyrosine-phosphorylated proteins in Trypanosoma brucei

    Nett, I. R. E., Davidson, L., Lamont, D. & Ferguson, M. A. J. Apr-2009 In : Eukaryotic Cell. 8, 4, p. 617-626, 10 p.

    Research output: Contribution to journal › Article

  286. Receptor occupancy and brain free fraction

    Watson, J., Wright, S., Lucas, A., Clarke, K. L., Viggers, J., Cheetham, S., Jeffrey, P., Porter, R. & Read, K. D. Apr-2009 In : Drug Metabolism and Disposition. 37, 4, p. 753-760, 8 p.

    Research output: Contribution to journal › Article

  287. Development of a Novel Virtual Screening Cascade Protocol to Identify Potential Trypanothione Reductase Inhibitors

    Perez-Pineiro, R., Burgos, A., Jones, D. C., Andrew, L. C., Rodriguez, H., Suarez, M., Fairlamb, A. H. & Wishart, D. S. 26-Mar-2009 In : Journal of Medicinal Chemistry. 52, 6, p. 1670-1680, 11 p.

    Research output: Contribution to journal › Article

  288. Targeted delivery of compounds to Trypanosoma brucei using the melamine motif

    Chollet, C., Baliani, A., Wong, P. E., Barrett, M. P. & Gilbert, I. H. 15-Mar-2009 In : Bioorganic & Medicinal Chemistry. 17, 6, p. 2512-2523, 12 p.

    Research output: Contribution to journal › Article

  289. Biochemistry: The evolution of ribozyme chemistry

    Wilson, T. J. & Lilley, D. M. J. 13-Mar-2009 In : Science. 323, 5920, p. 1436-1438, 3 p.

    Research output: Contribution to journal › Article

  290. Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase

    McCarthy, O., Musso-Buendia, A., Kaiser, M., Brun, R., Ruiz-Perez, L. M., Johansson, N. G., Pacanowska, D. G. & Gilbert, I. H. Feb-2009 In : European Journal of Medicinal Chemistry. 44, 2, p. 678-688, 11 p.

    Research output: Contribution to journal › Article

  291. Nucleosomes can invade DNA territories occupied by their neighbors

    Engeholm, M., de Jager, M., Flaus, A., Brenk, R., van Noort, J. & Owen-Hughes, T. Feb-2009 In : Nature Structural & Molecular Biology. 16, 2, p. 151-158, 8 p.

    Research output: Contribution to journal › Article

  292. Trypanosoma brucei UDP-glucose:glycoprotein glucosyltransferase has unusual substrate specificity and protects the parasite from stress

    Izquierdo, L., Atrih, A., Rodrigues, J. A., Jones, D. C. & Ferguson, M. A. J. Feb-2009 In : Eukaryotic Cell. 8, 2, p. 230-240, 11 p.

    Research output: Contribution to journal › Article

  293. The Glycogen-Binding Domain on the AMPK beta Subunit Allows the Kinase to Act as a Glycogen Sensor

    McBride, A., Ghilagaber, S., Nikolaev, A. & Hardie, D. G. 7-Jan-2009 In : Cell Metabolism. 9, 1, p. 23-34, 12 p.

    Research output: Contribution to journal › Article

  294. In vivo imaging of mammalian cells: cell engineering and viability

    Swedlow, J. R., Andrews, P. D. & Platani, M. 1-Jan-2009 In : Cold Spring Harbor Protocols. 4, 9

    Research output: Contribution to journal › Article

  295. In vivo imaging of mammalian cells: image acquisition and analysis

    Swedlow, J. R., Andrews, P. D. & Platani, M. 1-Jan-2009 In : Cold Spring Harbor Protocols. 4, 9

    Research output: Contribution to journal › Article

  296. Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni

    Musso-Buendía, J. A., Vidal, A. E., Carrero-Lérida, J., Ruiz-Pérez, L. M., González-Pacanowska, D., Kasinthan, G., Nguyen, C., Gilbert, I. H., Johansson, N. G. & Wilson, K. 1-Jan-2009 In : Journal of Enzyme Inhibition and Medicinal Chemistry. 24, 1, p. 111-116, 6 p.

    Research output: Contribution to journal › Article

  297. A comparative study of methylglyoxal metabolism in trypanosomatids

    Greig, N., Wyllie, S., Patterson, S. & Fairlamb, A. H. Jan-2009 In : FEBS Journal. 276, 2, p. 376-386, 11 p.

    Research output: Contribution to journal › Article

  298. Identification of a glycosylphosphatidylinositol anchor-modifying beta 1-3 N-acetylglucosaminyl transferase in Trypanosoma brucei

    Izquierdo, L., Nakanishi, M., Mehlert, A., MacHray, G., Barton, G. J. & Ferguson, M. A. J. Jan-2009 In : Molecular Microbiology. 71, 2, p. 478-491, 14 p.

    Research output: Contribution to journal › Article

  299. PIPs: human protein-protein interaction prediction database

    McDowall, M. D., Scott, M. S. & Barton, G. J. Jan-2009 In : Nucleic Acids Research. 37, p. D651-D656, 6 p.

    Research output: Contribution to journal › Article

  300. Streptococcus mutans SMU.623c codes for a functional, metal-dependent polysaccharide deacetylase that modulates interactions with salivary agglutinin

    Deng, D. M., Urch, J. E., ten Cate, J. M., Rao, V. A., van Aalten, D. M. F. & Crielaard, W. Jan-2009 In : Journal of Bacteriology. 191, 1, p. 394-402, 9 p.

    Research output: Contribution to journal › Article

  301. Diversity oriented syntheses of fused pyrimidines designed as potential antifolates

    Gibson, C. L., Huggan, J. K., Kennedy, A., Kiefer, L., Lee, J. H., Suckling, C. J., Clements, C., Harvey, A. L., Hunter, W. N. & Tulloch, L. B. 2009 In : Organic and Biomolecular Chemistry. 7, 9, p. 1829-1842, 14 p.

    Research output: Contribution to journal › Article

  302. Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity

    Howard, S. , Berdini, V. , Boulstridge, J. A. , Carr, M. G. , Cross, D. M. , Curry, J. , Devine, L. A. , Early, T. R. , Fazal, L. , Gill, A. L. , Heathcote, M. , Maman, S. , Matthews, J. E. , McMenamin, R. L. , Navarro, E. F. , O'Brien, M. A. , O'Reilly, M. , Rees, D. C. , Reule, M. , Tisi, D. & 3 others Williams, G., Vinković, M. & Wyatt, P. G. 2009 In : Journal of Medicinal Chemistry. 52, 2, p. 379-88, 10 p.

    Research output: Contribution to journal › Article

  303. Fragment-based drug discovery in academia: Experiences from a tuberculosis programme

    Heikkila, T. J., Surade, S., Silvestre, H. L., Dias, M. V. B., Blundell, T. L., Ciulli, A., Bromfield, K., Scott, D., Howard, N., Wen, S., Wei, A. H., Osborne, D. & Abell, C. 2009 From Molecules to Medicines: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism. Sussman, J. L. & Spadon, P. (eds.). Springer Netherlands, p. 21-36 16 p. (NATO Science for Peace and Security Series A: Chemistry and Biology).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  304. Glycosylphosphatidylinositol anchors

    Ferguson, M. A. J., Kinoshita, T. & Hart, G. W. 2009 Essentials of glycobiology. Varki, A. (ed.). 2nd ed. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, p. 143-162 20 p.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  305. How does human O-Glcnacase recognize O-Glcnacylated protein substrates?

    Schimpl, M., Borodkin, V. S. & Van Aalten, D. M. F. 2009 In : Glycobiology. 19, 11, p. 1369-1369, 1 p., 272

    Research output: Contribution to journal › Meeting abstract

  306. IDENTIFICATION OF NUCLEOLAR ASSOCIATED CHROMATIN LOCI REVEALS CLUES FOR NUCLEAR ARCHITECTURE

    van Koningsbruggen, S., Martin, D. M. A., Ariyurek, Y., den Dunnen, J. T. & Lamond, A. I. 2009 In : Cellular Oncology. 31, 2, p. 105-106, 2 p., O16

    Research output: Contribution to journal › Book/Film/Article review

  307. Kinomer v. 1.0: a database of systematically classified eukaryotic protein kinases

    Martin, D. M. A., Miranda-Saavedra, D. & Barton, G. J. 2009 In : Nucleic Acids Research. 37, Suppl. 1. Database issue, p. D244-D250, 7 p.

    Research output: Contribution to journal › Article

  308. Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites

    Baliani, A., Peal, V., Gros, L., Brun, R., Kaiser, M., Barrett, M. P. & Gilbert, I. H. 2009 In : Organic and Biomolecular Chemistry. 7, 6, p. 1154-1166, 13 p.

    Research output: Contribution to journal › Article

  309. Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold

    Dixon, M. J., Nathubhai, A., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M. 2009 In : Organic and Biomolecular Chemistry. 7, 2, p. 259-268, 10 p.

    Research output: Contribution to journal › Article

  310. Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide

    Fyfe, P. K., Rao, V. A., Zemla, A., Cameron, S. & Hunter, W. N. 2009 In : Angewandte Chemie International Edition. 48, 48, p. 9176-9179, 4 p.

    Research output: Contribution to journal › Article

  311. SPPS of the natural product chitinase inhibitor argifin: library generation and biological evaluation

    Dixon, M. J., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M. 2009 Peptides for youth: the proceedings of the 20th American Peptide Symposium. Del Valle, S., Escher, E. & Lubell, W. D. (eds.). New York: Springer, p. 143-144 2 p. (Advances in experimental medicine and biology).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  312. Synthesis and structure-based dissection of cyclic peptide chitinase inhibitors: new leads for antifungal and anti-inflammatory drugs

    Dixon, M. J., Nathubhai, A., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M. 2009 Peptides for youth: the proceedings of the 20th American Peptide Symposium. Del Valle, S., Escher, E. & Lubell, W. D. (eds.). New York: Springer, p. 525-526 2 p. (Advances in experimental medicine and biology).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  313. The GlcNAc-PI de-N-acetylase: structure, function, and activity

    Urbaniak, M. D. & Ferguson, M. A. J. 2009 In : Enzymes. 26, p. 49-64, 16 p.

    Research output: Contribution to journal › Article

  314. Specificity and reactivity in menaquinone biosynthesis: the structure of Escherichia coli MenD (2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase)

    Dawson, A., Fyfe, P. K. & Hunter, W. N. 31-Dec-2008 In : Journal of Molecular Biology. 384, 5, p. 1353-1368, 16 p.

    Research output: Contribution to journal › Article

  315. Structure of the OSR1 kinase, a hypertension drug target

    Villa, F., Deak, M., Alessi, D. R. & van Aalten, D. M. F. Dec-2008 In : Proteins: Structure, Function, and Bioinformatics. 73, 4, p. 1082-1087, 6 p.

    Research output: Contribution to journal › Article

  316. A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

    Towler, M. C., Fogarty, S., Hawley, S. A., Pan, D. A., Martin, D. M. A., Morrice, N. A., McCarthy, A., Galardo, M. N., Meroni, S. B., Cigorraga, S. B., Ashworth, A., Sakamoto, K. & Hardie, D. G. 15-Nov-2008 In : Biochemical Journal. 416, p. 114, 14 p.

    Research output: Contribution to journal › Article

  317. Structure of staphylococcus aureus EsxA suggests a contribution to virulence by action as a transport chaperone and/or adaptor protein

    Sundaramoorthy, R., Fyfe, P. K. & Hunter, W. N. 14-Nov-2008 In : Journal of Molecular Biology. 383, 3, p. 603-614, 12 p.

    Research output: Contribution to journal › Article

  318. Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.

    Ciulli, A., Scott, D. E., Ando, M., Reyes, F., Saldanha, S. A., Tuck, K. L., Chirgadze, D. Y., Blundell, T. L. & Abell, C. 3-Nov-2008 In : ChemBioChem. 9, 16, p. 2606-2611, 6 p.

    Research output: Contribution to journal › Article

  319. ATP-dependent ligases in trypanothione biosynthesis - kinetics of catalysis and inhibition by phosphinic acid pseudopeptides

    Oza, S. L., Chen, S., Wyllie, S., Coward, J. K. & Fairlamb, A. H. Nov-2008 In : FEBS Journal. 275, 21, p. 5408-5421, 14 p.

    Research output: Contribution to journal › Article

  320. GPIomics: Global Analysis of Glycosylphosphatidylinositol (GPI)-Anchored Molecules of Trypanosoma cruzi by Tandem Mass Spectrometry

    Nakayasu, E. S., Yashunsky, D. V., Nohara, L. L., Torrecilhas, A. C. T., Nikolaev, A. V. & Almeida, I. C. Nov-2008 In : Glycobiology. 18, 11, p. 974-974, 1 p., 140

    Research output: Contribution to journal › Book/Film/Article review

  321. Network pharmacology: the next paradigm in drug discovery

    Hopkins, A. L. Nov-2008 In : Nature Chemical Biology. 4, 11, p. 682-690, 9 p.

    Research output: Contribution to journal › Scientific review

  322. Sugar nucleotide metabolism and compartmentation in Trypanosoma brucei: new insights from UDP-GlcNAc and UDP-Glc biosynthesis

    Marino, K., Guther, M. L. S. & Ferguson, M. Nov-2008 In : Glycobiology. 18, 11, p. 946-946, 1 p.

    Research output: Contribution to journal › Meeting abstract

  323. Synthesis and testing of peptides for anti-prion activity

    Sellarajah, S., Boussard, C., Lekishvili, T., Brown, D. R. & Gilbert, I. H. Nov-2008 In : European Journal of Medicinal Chemistry. 43, 11, p. 2418-2427, 10 p.

    Research output: Contribution to journal › Article

  324. Structural insights into mechanism and specificity of O-GlcNAc transferase

    Clarke, A. J., Hurtado-Guerrero, R., Pathak, S., Schuettelkopf, A., Borodkin, V., Shepherd, S. M., Ibrahim, A. F. M. & van Aalten, D. M. F. 22-Oct-2008 In : EMBO Journal. 27, 20, p. 2780-2788, 9 p.

    Research output: Contribution to journal › Article

  325. Identification and characterization of FUS/TLS as a new target of ATM

    Gardiner, M., Toth, R., Vandermoere, F., Morrice, N. A. & Rouse, J. 15-Oct-2008 In : Biochemical Journal. 415, p. 297-307, 11 p.

    Research output: Contribution to journal › Article

  326. Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases

    Gibellini, F., Hunter, W. N. & Smith, T. K. 1-Oct-2008 In : Biochemical Journal. 415, p. 135-144, 10 p.

    Research output: Contribution to journal › Article

  327. Molecular mechanisms of O-GlcNAcylation

    Hurtado-Guerrero, R., Dorfmueller, H. C. & van Aalten, D. M. F. Oct-2008 In : Current Opinion in Structural Biology. 18, 5, p. 551-557

    Research output: Contribution to journal › Article

  328. Probing Enzymes Late in the Trypanosomal Glycosylphosphatidylinositol Biosynthetic Pathway with Synthetic Glycosylphosphatidylinositol Analogues

    Urbaniak, M. D., Yashunsky, D. V., Crossman, A., Nikolaev, A. V. & Ferguson, M. A. J. Oct-2008 In : ACS Chemical Biology. 3, 10, p. 625-634, 10 p.

    Research output: Contribution to journal › Article

  329. Putting glycobiology on a structural footing

    van Aalten, D. M. F. & Strynadka, N. C. J. Oct-2008 In : Current Opinion in Structural Biology. 18, 5, p. 525-526, 2 p.

    Research output: Contribution to journal › Editorial

  330. A new family of transcription factors

    Yamada, Y., Wang, H-Y., Fukuzawa, M., Barton, G. J. & Williams, J. G. 15-Sep-2008 In : Development. 135, 18, p. 3093-3101, 9 p.

    Research output: Contribution to journal › Article

  331. Structural and mechanistic insights into type II trypanosomatid tryparedoxin-dependent peroxidases

    Alphey, M. S., Konig, J. & Fairlamb, A. H. 15-Sep-2008 In : Biochemical Journal. 414, 3, p. 375-381, 7 p.

    Research output: Contribution to journal › Article

  332. Phosphatidylethanolamine in Trypanosoma brucei is organized in two separate pools and is synthesized exclusively by the Kennedy pathway

    Signorell, A., Rauch, M., Jelk, J., Ferguson, M. A. J. & Buetikofer, P. 29-Aug-2008 In : Journal of Biological Chemistry. 283, 35, p. 23636-23644, 9 p.

    Research output: Contribution to journal › Article

  333. Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design

    Wyatt, P. G. , Woodhead, A. J. , Berdini, V. , Boulstridge, J. A. , Carr, M. G. , Cross, D. M. , Davis, D. J. , Devine, L. A. , Early, T. R. , Feltell, R. E. , Lewis, E. J. , McMenamin, R. L. , Navarro, E. F. , O'Brien, M. A. , O'Reilly, M. , Reule, M. , Saxty, G. , Seavers, L. C. A. , Smith, D-M. , Squires, M. S. & 3 others Trewartha, G., Walker, M. T. & Woolford, A. J. -A. 28-Aug-2008 In : Journal of Medicinal Chemistry. 51, 16, p. 4986-4999, 14 p.

    Research output: Contribution to journal › Article

  334. Chemical dissection of the link between streptozotocin, O-GlcNAc, and pancreatic cell death

    Pathak, S., Dorfmueller, H. C., Borodkin, V. S. & van Aalten, D. M. F. 25-Aug-2008 In : Chemistry & Biology. 15, 8, p. 799-807, 9 p.

    Research output: Contribution to journal › Article

  335. COMP 90-The trouble with translating information into medicines: strategies for embracing serendipity and uncertainty

    Hopkins, A. L. 17-Aug-2008 In : Abstracts of Papers of the American Chemical Society. 236, p. -, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  336. Probing Trypanosoma brucei glycosylphosphatidylinositol biosynthesis using novel precursor-analogues

    Urbaniak, M. D., Crossman, A. & Ferguson, M. A. J. Aug-2008 In : Chemical Biology & Drug Design. 72, 2, p. 127-132, 6 p.

    Research output: Contribution to journal › Article

  337. Synthesis of cyclic peptide chitinase inhibitors: natural products,with chemotherapeutic potential

    Dixon, M., Nathubhai, A., Andersen, O., van Aalten, D. & Eggleston, I. Aug-2008 In : Journal of Peptide Science. 14, S1, p. 13-13, 1 p., S02-4

    Research output: Contribution to journal › Book/Film/Article review

  338. Synthetic approaches to cyclic peptide natural products as chitinase inhibitors

    Dixon, M., Giuntini, F., Nathubhai, A., Andersen, O., van Aalten, D. & Eggleston, I. Aug-2008 In : Journal of Peptide Science. 14, S1, p. 55-55, 1 p., P10102-031

    Research output: Contribution to journal › Book/Film/Article review

  339. Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis

    Crossman, A. T., Urbaniak, M. D. & Ferguson, M. A. J. 7-Jul-2008 In : Carbohydrate Research. 343, 9, p. 1478-1481, 4 p.

    Research output: Contribution to journal › Article

  340. Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes

    Sienkiewicz, N., Jaroslawski, S., Wyllie, S. & Fairlamb, A. H. Jul-2008 In : Molecular Microbiology. 69, 2, p. 520-533, 14 p.

    Research output: Contribution to journal › Article

  341. Evaluation of direct transport pathways of glycine receptor antagonists and an angiotensin antagonist from the nasal cavity to the central nervous system in the rat model

    Charlton, S. T., Whetstone, J., Fayinka, S. T., Read, K. D., Illum, L. & Davis, S. S. Jul-2008 In : Pharmaceutical Research. 25, 7, p. 1531-1543, 13 p.

    Research output: Contribution to journal › Article

  342. SCANPS: a web server for iterative protein sequence database searching by dynamic programing, with display in a hierarchical SCOP browser

    Walsh, T. P., Webber, C., Searle, S., Sturrock, S. S. & Barton, G. J. Jul-2008 In : Nucleic Acids Research. 36, p. W25-W29, 5 p.

    Research output: Contribution to journal › Article

  343. TarO: a target optimisation system for structural biology

    Overton, I. M., van Niekerk, C. A. J., Carter, L. G., Dawson, A., Martin, D. M. A., Cameron, S., McMahon, S. A., White, M. F., Hunter, W. N., Naismith, J. H. & Barton, G. J. Jul-2008 In : Nucleic Acids Research. 36, p. W190-W196, 7 p.

    Research output: Contribution to journal › Article

  344. The Jpred 3 secondary structure prediction server

    Cole, C., Barber, J. D. & Barton, G. J. Jul-2008 In : Nucleic Acids Research. 36, p. W197-W201, 5 p.

    Research output: Contribution to journal › Article

  345. Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities

    Fyfe, P. K., Oza, S. L., Fairlamb, A. H. & Hunter, W. N. 20-Jun-2008 In : Journal of Biological Chemistry. 283, 25, p. 17672-17680, 9 p.

    Research output: Contribution to journal › Article

  346. The synthesis of UDP-N-acetylglucosamine is essential for bloodstream form Trypanosoma brucei in vitro and in vivo and UDP-N-acetylglucosamine starvation reveals a hierarchy in parasite protein glycosylation

    Stokes, M. J., Guther, M. L. S., Turnock, D. C., Prescott, A. R., Martin, K. L., Alphey, M. S. & Ferguson, M. A. J. 6-Jun-2008 In : Journal of Biological Chemistry. 283, 23, p. 16147-16161, 15 p.

    Research output: Contribution to journal › Article

  347. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

    Huang, X., Wullschleger, S., Shpiro, N., McGuire, V. A., Sakamoto, K., Woods, Y. L., McBurnie, W., Fleming, S. & Alessi, D. R. 1-Jun-2008 In : Biochemical Journal. 412, p. 211-221, 11 p.

    Research output: Contribution to journal › Article

  348. Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-D-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery

    Sgraja, T., Alphey, M. S., Ghilagaber, S., Marquez, R., Robertson, M. N., Hemmings, J. L., Lauw, S., Rohdich, F., Bacher, A., Eisenreich, W., Illarionova, V. & Hunter, W. N. Jun-2008 In : FEBS Journal. 275, 11, p. 2779-2794, 16 p.

    Research output: Contribution to journal › Article

  349. Targetes gene regulation mediated by nucleolar snoRNAs

    Ono, M., Scott, M., Yamada, K., Barton, G., Hutvagner, G. & Lamond, A. Jun-2008 In : FEBS Journal. 275, S1, p. 73-73, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  350. Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer

    McCracken, S. R. C., Ramsay, A., Heer, R., Mathers, M. E., Jenkins, B. L., Edwards, J., Robson, C. N., Marquez, R., Cohen, P. & Leung, H. Y. 8-May-2008 In : Oncogene. 27, 21, p. 2978-2988, 11 p.

    Research output: Contribution to journal › Article

  351. Deletion of the TbALG3 gene demonstrates site-specific N-glycosylation and N-glycan processing in Trypanosoma brucei

    Manthri, S., Guther, M. L. S., Izquierdo, L., Acosta-Serrano, A. & Ferguson, M. A. J. May-2008 In : Glycobiology. 18, 5, p. 367-383, 17 p.

    Research output: Contribution to journal › Article

  352. Genome analysis of the unicellular green alga Chlamydomonas reinhardtii indicates an ancient evolutionary origin for key pattern recognition and cell-signaling protein families

    Wheeler, G. L., Miranda-Saavedra, D. & Barton, G. J. May-2008 In : Genetics. 179, 1, p. 193-197, 5 p.

    Research output: Contribution to journal › Article

  353. The cancer chemopreventive actions of phytochemicals derived from glucosinolates

    Hayes, J. D., Kelleher, M. O. & Eggleston, I. M. May-2008 In : European Journal of Nutrition. 47, p. 73-88, 16 p.

    Research output: Contribution to journal › Scientific review

  354. ParCrys: a Parzen window density estimation approach to protein crystallization propensity prediction

    Overton, I. M., Padovani, G., Girolami, M. A. & Barton, G. J. 1-Apr-2008 In : BMC Bioinformatics. 24, 7, p. 901-907, 7 p.

    Research output: Contribution to journal › Article

  355. Crystal structures of Toxoplasma gondii pterin-4a-carbinolamine dehydratase and comparisons with mammalian and parasite orthologues

    Cameron, S., Fyffe, S. A., Goldie, S. & Hunter, W. N. Apr-2008 In : Molecular and Biochemical Parasitology. 158, 2, p. 131-138, 8 p.

    Research output: Contribution to journal › Article

  356. GPIs on a chip

    Ferguson, M. A. J. Apr-2008 In : Nature Chemical Biology. 4, 4, p. 223-224, 2 p.

    Research output: Contribution to journal › Comment/debate

  357. Kinetoplastids: related protozoan pathogens, different diseases

    Stuart, K., Brun, R., Croft, S., Fairlamb, A., Guertler, R. E., McKerrow, J., Reed, S. & Tarleton, R. Apr-2008 In : Journal of Clinical Investigation. 118, 4, p. 1301-1310, 10 p.

    Research output: Contribution to journal › Scientific review

  358. Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials

    Wyllie, S., Vickers, T. J. & Fairlamb, A. H. Apr-2008 In : Antimicrobial Agents and Chemotherapy. 52, 4, p. 1359-1365, 7 p.

    Research output: Contribution to journal › Article

  359. Lessons learnt from assembling screening libraries for drug discovery for neglected diseases

    Brenk, R., Schipani, A., James, D., Krasowski, A., Gilbert, I. H., Frearson, J. & Wyatt, P. G. Mar-2008 In : ChemMedChem. 3, 3, p. 435-444, 10 p.

    Research output: Contribution to journal › Article

  360. Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin

    Andersen, O. A., Nathubhai, A., Dixon, M. J., Eggleston, I. M. & van Aalten, D. M. F. Mar-2008 In : Chemistry & Biology. 15, 3, p. 295-301, 7 p.

    Research output: Contribution to journal › Article

  361. Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

    Cavazzuti, A., Paglietti, G., Hunter, W. N., Gamarro, F., Piras, S., Loriga, M., Alleca, S., Corona, P., McLuskey, K., Tulloch, L., Gibellini, F., Ferrari, S. & Costin, M. P. 5-Feb-2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 5, p. 1448-1453, 6 p.

    Research output: Contribution to journal › Article

  362. Inequalities in access to education and healthcare

    Nunn, J., Freeman, R., Anderson, E., Carneiro, L. C., Carneiro, M. S. A., Formicola, A., Frezel, R., Kayitenkore, J., Luhanga, C., Molina, G., Morio, I., Nartey, N. O., Ngom, P. I., Navarro, M. F. . L., Segura, A., Oliver, S., Thompson, S., Wandera, M. & Yazdanie, N. Feb-2008 In : European Journal of Dental Education. 12, p. 30-39, 10 p.

    Research output: Contribution to journal › Article

  363. The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction

    Manning, J. R., Jefferson, E. R. & Barton, G. J. 25-Jan-2008 In : BMC Bioinformatics. 9, p. -, 16 p., 51

    Research output: Contribution to journal › Article

  364. A comparison of SCOP and CATH with respect to domain-domain interactions

    Jefferson, E. R., Walsh, T. P. & Barton, G. J. Jan-2008 In : Proteins: Structure, Function, and Bioinformatics. 70, 1, p. 54-62, 9 p.

    Research output: Contribution to journal › Article

  365. Evaluation of a head mounted camera for clinical dental teaching

    Chadwick, R. G., Carena, A. P., Hunter, B. & Campbell, K. Jan-2008 In : British Dental Journal. 204, 2, p. 93-96, 4 p.

    Research output: Contribution to journal › Article

  366. Sequence alignment for molecular replacement

    Barton, G. J. Jan-2008 In : Acta Crystallographica Section D: Biological Crystallography. 64, p. 25-32, 8 p.

    Research output: Contribution to journal › Article

  367. Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham.

    Gallo, M. B. C., Marques, A. S. F., Vieira, P. C., da Silva, M. F. . G. F., Fernandes, J. B., Silva, M., Guido, R. V., Oliva, G., Thiemann, O. H., Albuquerque, S. & Fairlamb, A. H. 2008 In : Zeitschrift für Naturforschung C: a Journal of Biosciences. 63, 5-6, p. 371-382, 12 p.

    Research output: Contribution to journal › Article

  368. Genomic-scale prioritization of drug targets: the TDR Targets database

    Agüero, F. , Al-Lazikani, B. , Aslett, M. , Berriman, M. , Buckner, F. S. , Campbell, R. K. , Carmona, S. , Carruthers, I. M. , Chan, A. W. E. , Chen, F. , Crowther, G. J. , Doyle, M. A. , Hertz-Fowler, C. , Hopkins, A. L. , McAllister, G. , Nwaka, S. , Overington, J. P. , Pain, A. , Paolini, G. V. , Pieper, U. & 8 others Ralph, S. A., Riechers, A., Roos, D. S., Sali, A., Shanmugam, D., Suzuki, T., Van Voorhis, W. C. & Verlinde, C. L. M. J. 2008 In : Nature Reviews Drug Discovery. 7, 11, p. 900-7, 8 p.

    Research output: Contribution to journal › Article

  369. Inhibition of trypanothione reductase and glutathione reductase by ferrocenic 4-aminoquinoline ureas

    Blackie, M. A. L., Saravanamuthu, A., Fairlamb, A. H. & Chibale, K. 2008 In : ARKIVOC. 2008, vi, p. 52-60, 9 p.

    Research output: Contribution to journal › Article

  370. Inhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysis

    Hirsch, A. K. H., Alphey, M. S., Lauw, S., Seet, M., Barandun, L., Eisenreich, W., Rohdich, F., Hunter, W. N., Bacher, A. & Diederich, F. 2008 In : Organic and Biomolecular Chemistry. 6, 15, p. 2719-2730, 12 p.

    Research output: Contribution to journal › Article

  371. The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design

    Lucas-Lopez, C., Allingham, J. S., Lebl, T., Lawson, C. P. A. T., Brenk, R., Sellers, J. R., Rayment, I. & Westwood, N. J. 2008 In : Organic and Biomolecular Chemistry. 6, 12, p. 2076-2084, 9 p.

    Research output: Contribution to journal › Article

  372. Toward an improved prediction of human in vivo brain penetration

    Summerfield, S. G., Lucas, A. J., Porter, R. A., Jeffrey, P., Gunn, R. N., Read, K. R., Stevens, A. J., Metcalf, A. C., Osuna-Cabello, M. C., Kilford, P. J., Passchier, J. & Ruffo, A. D. 2008 In : Xenobiotica. 38, 12, p. 1518-1535, 18 p.

    Research output: Contribution to journal › Article

  373. The selectivity of protein kinase inhibitors: a further update

    Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., Mclauchlan, H., Klevernic, I., Arthur, J. S. C., Alessi, D. R. & Cohen, P. 15-Dec-2007 In : Biochemical Journal. 408, p. 297-315, 19 p.

    Research output: Contribution to journal › Article

  374. Efficient synthesis of 1,3,7-substituted xanthines by a safety-catch protection strategy

    Allwood, M., Cannan, B., van Aalten, D. M. F. & Eggleston, I. M. 10-Dec-2007 In : Tetrahedron. 63, 50, p. 12294-12302, 9 p.

    Research output: Contribution to journal › Article

  375. Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development

    Eoh, H., Brown, A. C., Buetow, L., Hunter, W. N., Parish, T., Kaur, D., Brennan, P. J. & Crick, D. C. Dec-2007 In : Journal of Bacteriology. 189, 24, p. 8922-8927, 6 p.

    Research output: Contribution to journal › Article

  376. Gene-based sequence diversity analysis of field pea (Pisum)

    Jing, R., Johnson, R., Seres, A., Kiss, G., Ambrose, M. J., Knox, M. R., Ellis, T. H. N. & Flavell, A. J. Dec-2007 In : Genetics. 177, 4, p. 2263-2275, 13 p.

    Research output: Contribution to journal › Article

  377. Micro-magnetic resonance imaging of avian embryos

    Li, X., Liu, J., Davey, M., Duce, S., Jaberi, N., Liu, G., Davidson, G., Tenent, S., Mahood, R., Brown, P., Cunningham, C., Bain, A., Beattie, K., McDonald, L., Schmidt, K., Towers, M., Tickle, C. & Chudek, S. Dec-2007 In : Journal of Anatomy. 211, 6, p. 798-809, 12 p.

    Research output: Contribution to journal › Article

  378. Target assessment for antiparasitic drug discovery

    Frearson, J. A., Wyatt, P. G., Gilbert, I. H. & Fairlamb, A. H. Dec-2007 In : Trends in Parasitology. 23, 12, p. 589-595, 7 p.

    Research output: Contribution to journal › Scientific review

  379. Distance determination in heterogeneous DNA model systems by pulsed EPR

    Ward, R., Keeble, D. J., El-Mkami, H. & Norman, D. G. Nov-2007 In : ChemBioChem. 8, 16, p. 1957-1964, 8 p.

    Research output: Contribution to journal › Article

  380. Picking pockets to fuel antimicrobial drug discovery

    Hunter, W. N. Nov-2007 In : Biochemical Society Transactions. 35, p. 980-984, 5 p.

    Research output: Contribution to journal › Article

  381. Quinuclidine derivatives as potential antiparasitics

    Cammerer, S. B., Jimenez, C., Jones, S., Gros, L., Lorente, S. O., Rodrigues, C., Rodrigues, J. C. F., Caldera, A., Perez, L. M. R., da Souza, W., Kaiser, M., Brun, R., Urbina, J. A., Pacanowska, D. G. & Gilbert, I. H. Nov-2007 In : Antimicrobial Agents and Chemotherapy. 51, 11, p. 4049-4061, 13 p.

    Research output: Contribution to journal › Article

  382. Structure of Staphylococcus aureus 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in complex with acetoacetyl-CoA

    Ulaganathan, V., Agacan, M. F., Buetow, L., Tulloch, L. B. & Hunter, W. N. Nov-2007 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 63, p. 908-913, 6 p.

    Research output: Contribution to journal › Article

  383. The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphatesynthase, an essential enzyme, provides a platform for drug discovery

    Buetow, L., Brown, A. C., Parish, T. & Hunter, W. N. 23-Oct-2007 In : BMC Structural Biology. 7, p. -, 11 p., 68

    Research output: Contribution to journal › Article

  384. Mechanistic insights into the cure of prion disease by novel antiprion compounds

    Webb, S., Lekishvili, T., Loeschner, C., Sellarajah, S., Prelli, F., Wisniewski, T., Gilbert, I. H. & Brown, D. R. Oct-2007 In : Journal of Virology. 81, 19, p. 10729-10741, 13 p.

    Research output: Contribution to journal › Article

  385. The de novo synthesis of GDP-fucose is essential for flagellar adhesion and cell growth in trypanosoma brucei

    Turnock, D. C., Izquierdo, L. & Ferguson, M. A. J. Sep-2007 In : Journal of Biological Chemistry. 282, 39, p. 28853-28863, 11 p.

    Research output: Contribution to journal › Article

  386. Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major

    Turnock, D. C. & Ferguson, M. A. J. Aug-2007 In : Eukaryotic Cell. 6, 8, p. 1450-1463, 14 p.

    Research output: Contribution to journal › Scientific review

  387. Synthesis and biological evaluation of phosphate Prodrugs of 4-Phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase

    Ruda, G. F., Alibu, V. P., Mitsos, C., Bidet, O., Kaiser, M., Brun, R., Barrett, M. P. & Gilbert, I. H. Aug-2007 In : ChemMedChem. 2, 8, p. 1169-1180, 12 p.

    Research output: Contribution to journal › Article

  388. Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives

    Sealey-Cardona, M., Cammerer, S., Jones, S., Ruiz-Perez, L. M., Brun, R., Gilbert, I. H., Urbina, J. A. & Gonzalez-Pacanowska, D. Jun-2007 In : Antimicrobial Agents and Chemotherapy. 51, 6, p. 2123-2129, 7 p.

    Research output: Contribution to journal › Article

  389. Alterations on the growth and ultrastructure of Leishmania chagasi induced by squalene synthase inhibitors

    Granthon, A. C., Braga, M. V., Rodrigues, J. C. F., Cammerer, S., Lorente, S. O., Gilbert, I. H., Urbina, J. A. & de Souza, W. 15-May-2007 In : Veterinary Parasitology. 146, 1-2, p. 25-34, 10 p.

    Research output: Contribution to journal › Article

  390. A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription

    Gorski, J. J., Pathak, S., Panov, K., Kasciukovic, T., Panova, T., Russell, J. & Zomerdijk, J. C. B. M. Mar-2007 In : The EMBO Journal. 26, 6, p. 1560-1568, 9 p.

    Research output: Contribution to journal › Article

  391. Structure of the glycosylphosphatidylinositol anchor of the Trypanosoma brucei transferrin receptor

    Mehlert, A. & Ferguson, M. A. J. Feb-2007 In : Molecular and Biochemical Parasitology. 151, 2, p. 220-223, 4 p.

    Research output: Contribution to journal › Article

  392. Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates

    Sundaramoorthy, R., Iulek, J., Barrett, M. P., Bidet, O., Ruda, G. F., Gilbert, I. H. & Hunter, W. N. Jan-2007 In : FEBS Journal. 274, 1, p. 275-286, 12 p.

    Research output: Contribution to journal › Article

  393. Evidence-based guidelines for management of attention-deficit/hyperactivity disorder in adolescents in transition to adult services and in adults: recommendations from the British Association for Psychopharmacology

    Nutt, D. J., Fone, K., Asherson, P., Bramble, D., Hill, P., Matthews, K., Morris, K. A., Santosh, P., Sonuga-Barke, E., Taylor, E., Weiss, M., Young, S. & Consensus Grp Jan-2007 In : Journal of Psychopharmacology. 21, 1, p. 10-41, 32 p.

    Research output: Contribution to journal › Scientific review

  394. 31P solid-state MAS-NMR spectroscopy of the compounds that form in phosphate-bonded dental casting investment materials during setting

    Scrimgeour, S. N., Chudek, J. A., Cowper, G. A. & Lloyd, C. H. 2007 In : Dental Materials. 23, 8, p. 934-943, 10 p.

    Research output: Contribution to journal › Article

  395. A novel approach to the visualisation of heat-induced structural change in bone

    Thompson, T. J. U. & Chudek, S. 2007 In : Science & Justice. 47, 2, p. 99-104, 6 p.

    Research output: Contribution to journal › Article

  396. Classification and functional annotation of eukaryotic protein kinases

    Miranda-Saavedra, D. & Barton, G. J. 2007 In : Proteins: Structure, Function, and Bioinformatics. 68, 4, p. 893-914, 22 p.

    Research output: Contribution to journal › Article

  397. Design and synthesis of an array of selective androgen receptor modulators

    Trump, R. P., Blanc, J-B. E., Stewart, E. L., Brown, P. J., Caivano, M., Gray, D. W., Hoekstra, W. J., Willson, T. M., Han, B. & Turnbull, P. 2007 In : Journal of Combinatorial Chemistry. 9, 1, p. 107-14, 8 p.

    Research output: Contribution to journal › Article

  398. Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

    Carlton, J. M. , Hirt, R. P. , Silva, J. C. , Delcher, A. L. , Schatz, M. , Zhao, Q. , Wortman, J. R. , Bidwell, S. L. , Alsmark, U. C. M. , Besteiro, S. , Sicheritz-Ponten, T. , Noel, C. J. , Dacks, J. B. , Foster, P. G. , Simillion, C. , Van de Peer, Y. , Miranda-Saavedra, D. , Barton, G. J. , Westrop, G. D. , Muller, S. & 45 others Dessi, D., Fiori, P. L., Ren, Q., Paulsen, I., Zhang, H., Bastida-Corcuera, F. D., Simoes-Barbosa, A., Brown, M. T., Hayes, R. D., Mukherjee, M., Okumura, C. Y., Schneider, R., Smith, A. J., Vanacova, S., Villalvazo, M., Haas, B. J., Pertea, M., Feldblyum, T. V., Utterback, T. R., Shu, C-L., Osoegawa, K., Jong, P. J. ., Hrdy, I., Horvathova, L., Zubacova, Z., Dolezal, P., Malik, S-B., Logsdon, J. M., Henze, K., Gupta, A., Wang, C. C., Dunne, R. L., Upcroft, J. A., Upcroft, P., White, O., Salzberg, S. L., Tang, P., Chiu, C-H., Lee, Y-S., Embley, T. M., Coombs, G. H., Mottram, J. C., Tachezy, J., Fraser-Liggett, C. M. & Johnson, P. J. 2007 In : Science. 315, 5809, p. 207-212, 6 p.

    Research output: Contribution to journal › Article

  399. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase

    Goransson, O., McBride, A., Hawley, S. A., Ross, F. A., Shpiro, N., Foretz, M., Viollet, B., Hardie, D. G. & Sakamoto, K. 2007 In : Journal of Biological Chemistry. 282, 45, p. 32549-32560, 12 p.

    Research output: Contribution to journal › Article

  400. Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease

    Salter, M., Biggadike, K., Matthews, J. L., West, M. R., Haase, M. V., Farrow, S. N., Uings, I. J. & Gray, D. W. 2007 In : American Journal of Physiology: Lung Cellular and Molecular Physiology. 293, 3, p. L660-7, 8 p.

    Research output: Contribution to journal › Article

  401. Probabilistic prediction and ranking of human protein-protein interactions

    Scott, M. S. & Barton, G. J. 2007 In : BMC Bioinformatics. 8, p. 239, 1 p.

    Research output: Contribution to journal › Article

  402. Proteins interacting with Saccharomyces cerevisiae type 1 protein phosphatase catalytic subunit identified by single-step affinity purification and mass spectrometry

    Walsh, E. P., Lamont, D. J., Beattie, K. A. & Stark, M. J. R. 2007 In : Methods in Molecular Biology (Clifton, N.J.). 365, p. 235-246, 12 p.

    Research output: Contribution to journal › Article

  403. Structure and reactivity of LpxD, the N-acyltransferase of lipid A biosynthesis

    Buetow, L., Smith, T. K., Dawson, A., Fyffe, S., Hunter, W. N. & Thornton, J. M. (ed.) 2007 In : Proceedings of the National Academy of Sciences of the United States of America. 104, 11, p. 4321-4326, 6 p.

    Research output: Contribution to journal › Article

  404. The chemical synthesis of glycosylphosphatidylinositol anchors from Trypanosoma cruzi Trypomastigote mucins: exploration of ester and acetal type permanent protecting groups

    Yashunsky, D. V., Borodkin, V. S., McGivern, P. G., Ferguson, M. A. J. & Nikolaev, A. V. 2007 Frontiers in modern carbohydrate chemistry . Demchenko, A. V. (ed.). Washington: American Chemical Society, p. 285-306 22 p. (ACS Symposium series).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  405. The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe

    Miranda-Saavedra, D., Stark, M. J. R., Packer, J. C., Vivares, C. P., Doerig, C. & Barton, G. J. 2007 In : BMC Genomics. 8, 309

    Research output: Contribution to journal › Article

  406. The determination of phosphorus containing compounds in dental casting investment products by 31P solid-state MAS-NMR spectroscopy

    Scrimgeour, S. N., Chudek, J. A. & Lloyd, C. H. 2007 In : Dental Materials. 23, 4, p. 415-424, 10 p.

    Research output: Contribution to journal › Article

  407. The tagged microarray marker (TAM) method for high-throughput detection of single nucleotide and indel polymorphisms

    Jing, R., Bolshakov, V. & Flavell, A. J. 2007 In : Nature Protocols. 2, 1, p. 168-177, 10 p.

    Research output: Contribution to journal › Article

  408. Correction: First synthesis of argadin: a nanomolar inhibitor of family-18 chitinases

    Dixon, M. J., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M. 11-Dec-2006 In : European Journal of Organic Chemistry. 2006, 24, p. 5602, 1 p.

    Research output: Contribution to journal › Article

  409. GPI-anchored proteins and free GPI glycolipids of procyclic form Trypanosoma brucei are nonessential for growth, are required for colonization of the tsetse fly, and are not the only components of the surface coat

    Guther, M. L. S., Lee, S., Tetley, L., Acosta-Serrano, A. & Ferguson, M. A. J. 1-Dec-2006 In : Molecular Biology of the Cell. 17, 12, p. 5265-5274, 10 p.

    Research output: Contribution to journal › Article

  410. Identification of novel inhibitors of UDP-Glc 4 '-epimerase, a validated drug target for African sleeping sickness

    Urbaniak, M. D., Tabudravu, J. N., Msaki, A., Matera, K. M., Brenk, R., Jaspars, M. & Ferguson, M. A. J. 15-Nov-2006 In : Bioorganic & Medicinal Chemistry Letters. 16, 22, p. 5744-5747, 4 p.

    Research output: Contribution to journal › Article

  411. Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4 '-epimerase conditional null mutant

    Urbaniak, M. D., Turnock, D. C. & Ferguson, M. A. J. Nov-2006 In : Eukaryotic Cell. 5, 11, p. 1906-1913, 8 p.

    Research output: Contribution to journal › Article

  412. Evaluation of azasterols as anti-parasitics

    Gros, L., Lorente, S. O., Jimenez, C. J., Yardley, V., Rattray, L., Wharton, H., Little, S., Croft, S. L., Ruiz-Perez, L. M., Gonzalez-Pacanowska, D. & Gilbert, I. H. Oct-2006 In : Journal of Medicinal Chemistry. 49, 20, p. 6094-6103, 10 p.

    Research output: Contribution to journal › Article

  413. Screening-based discovery and structural dissection of a novel family 18 chitinase inhibitor

    Schüttelkopf, A. W., Andersen, O. A., Rao, F. V., Allwood, M., Lloyd, C., Eggleston, I. M. & van Aalten, D. M. F. 15-Sep-2006 In : Journal of Biological Chemistry. 281, 37, p. 27278-27285, 8 p.

    Research output: Contribution to journal › Article

  414. Characterization of the glycosylphosphatidylinositol anchor of the immunodominant Cryptosporidium parvum 17-kDa antigen

    Priest, J. W., Mehlert, A., Moss, D. M., Arrowood, M. J. & Ferguson, M. A. J. Sep-2006 In : Molecular and Biochemical Parasitology. 149, 1, p. 108-112, 5 p.

    Research output: Contribution to journal › Article

  415. Trypanosoma brucei UDP-galactose-4 '-epimerase in ternary complex with NAD(+) and the substrate analogue UDP-4-deoxy-4-fluoro-alpha-D-galactose

    Alphey, M. S., Burton, A., Urbaniak, M. D., Boons, G-J., Ferguson, M. A. J. & Hunter, W. N. Sep-2006 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 62, 9, p. 829-834, 6 p.

    Research output: Contribution to journal › Article

  416. Synthetic glycovaccine protects against the bite of Leishmania-infected sand flies

    Rogers, M. E., Sizova, O. V., Ferguson, M. A. J., Nikolaev, A. V. & Bates, P. A. 15-Aug-2006 In : Journal of Infectious Diseases. 194, 4, p. 512-518, 7 p.

    Research output: Contribution to journal › Article

  417. New azasterols against Trypanosoma brucei: Role of 24-sterol methyltransferase in inhibitor action

    Gros, L., Castillo-Acosta, V. M., Jimenez Jimenez, C., Sealey-Cardona, M., Vargas, S., Manuel Estevez, A., Yardley, V., Rattray, L., Croft, S. L., Ruiz-Perez, L. M., Urbina, J. A., Gilbert, I. H. & Gonzalez-Pacanowska, D. Aug-2006 In : Antimicrobial Agents and Chemotherapy. 50, 8, p. 2595-2601, 7 p.

    Research output: Contribution to journal › Article

  418. Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines

    Wiethe, R. W., Stewart, E. L., Drewry, D. H., Gray, D. W., Mehbob, A. & Hoekstra, W. J. 15-Jul-2006 In : Bioorganic & Medicinal Chemistry Letters. 16, 14, p. 3777-9, 3 p.

    Research output: Contribution to journal › Article

  419. Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase

    Mc Carthy, O. K., Schipani, A., Buendia, A. M., Ruiz-Perez, L. M., Kaiser, M., Brun, R., Pacanowska, D. G. & Gilbert, I. H. 15-Jul-2006 In : Bioorganic & Medicinal Chemistry Letters. 16, 14, p. 3809-3812, 4 p.

    Research output: Contribution to journal › Article

  420. Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase

    Nguyen, C., Ruda, G. F., Schipani, A., Kasinathan, G., Leal, I., Musso-Buendia, A., Kaiser, M., Brun, R., Ruiz-Perez, L. M., Sahlberg, B-L., Johansson, N. G., Gonzalez-Pacanowska, D. & Gilbert, I. H. 13-Jul-2006 In : Journal of Medicinal Chemistry. 49, 14, p. 4183-4195, 13 p.

    Research output: Contribution to journal › Article

  421. GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist

    Wilson, R. J., Giblin, G. M. P., Roomans, S., Rhodes, S. A., Cartwright, K-A., Shield, V. J., Brown, J., Wise, A., Chowdhury, J., Pritchard, S., Coote, J., Noel, L. S., Kenakin, T., Burns-Kurtis, C. L., Morrison, V., Gray, D. W. & Giles, H. Jun-2006 In : British Journal of Pharmacology. 148, 3, p. 326-39, 14 p.

    Research output: Contribution to journal › Article

  422. The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology

    MacRae, J. I., Obado, S. O., Turnock, D. C., Roper, J. R., Kierans, M., Kelly, J. M. & Ferguson, M. A. J. May-2006 In : Molecular and Biochemical Parasitology. 147, 1, p. 126-136, 11 p.

    Research output: Contribution to journal › Article

  423. Recombinant human PPAR-beta/delta ligand-binding domain is locked in an activated conformation by endogenous fatty acids

    Fyffe, S. A., Alphey, M. S., Buetow, L., Smith, T. K., Ferguson, M. A. J., Sorensen, M. D., Bjorkling, F. & Hunter, W. N. 3-Mar-2006 In : Journal of Molecular Biology. 356, 4, p. 1005-1013, 9 p.

    Research output: Contribution to journal › Article

  424. Skin wound closure with a novel shape-memory alloy fixator

    Ng, Y., Shimi, S. M., Kernohan, N., Frank, T. G., Campbell, P. A., Martin, D., Gove, J. & Cuschieri, A. Feb-2006 In : Surgical Endoscopy. 20, 2, p. 311-315, 5 p.

    Research output: Contribution to journal › Article

  425. Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from plasmodium falciparum, a key enzyme in fatty acid biosynthesis

    Wickramasinghe, S. R., Inglis, K. A., Urch, J. E., Müller, S., van Aalten, D. M. F. & Fairlamb, A. H. 15-Jan-2006 In : Biochemical Journal. 393, 2, p. 447-457, 11 p.

    Research output: Contribution to journal › Article

  426. Outer chain N-glycans are required for cell wall integrity and virulence of Candida albicans

    Bates, S., Hughes, H. B., Munro, C. A., Thomas, W. P. H., MacCallum, D. M., Bertram, G., Atrih, A., Ferguson, M. A. J., Brown, A. J. P., Odds, F. C. & Gow, N. A. R. 6-Jan-2006 In : Journal of Biological Chemistry. 281, 1, p. 90-98, 9 p.

    Research output: Contribution to journal › Article

  427. Reevaluation of the PPAR-beta/delta ligand binding domain model reveals why it exhibits the activated form

    Fyffe, S. A., Alphey, M. S., Buetow, L., Smith, T. K., Ferguson, M. A. J., Sorensen, M. D., Bjorkling, F. & Hunter, W. N. 6-Jan-2006 In : Molecular Cell. 21, 1, p. 1-2, 2 p.

    Research output: Contribution to journal › Editorial

  428. Biological units and their effect upon the properties and prediction of protein–protein interactions

    Jefferson, E. R., Walsh, T. P. & Barton, G. J. 2006 In : Journal of Molecular Biology. 364, 5, p. 1118-1129, 12 p.

    Research output: Contribution to journal › Article

  429. First synthesis of argadin: a nanomolar inhibitor of family-18 chitinases

    Dixon, M. J., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M. 2006 In : European Journal of Organic Chemistry. 2006, 22, p. 5002-5006, 5 p.

    Research output: Contribution to journal › Article

  430. GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels

    Dorfmueller, H. C., Borodkin, V. S., Schimpl, M., Shepherd, S. M., Shpiro, N. A. & van Aalten, D. M. F. 2006 In : Journal of the American Chemical Society. 128, 51, p. 16484-5, 2 p.

    Research output: Contribution to journal › Article

  431. Global mapping of pharmacological space

    Paolini, G. V., Shapland, R. H. B., Hoorn, W. P. ., Mason, J. S. & Hopkins, A. L. 2006 In : Nature Biotechnology. 24, 7, p. 805-815, 11 p.

    Research output: Contribution to journal › Article

  432. Probing molecular docking in a charged model binding site

    Brenk, R., Vetter, S. W., Boyce, S. E., Goodin, D. B. & Shoichet, B. K. 2006 In : Journal of Molecular Biology. 357, 5, p. 1449-1470, 22 p.

    Research output: Contribution to journal › Article

  433. Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis

    Rao, F. V., Dorfmueller, H. C., Villa, F., Allwood, M., Eggleston, I. M. & van Aalten, D. M. F. 2006 In : The EMBO Journal. 25, 7, p. 1569-1578, 10 p.

    Research output: Contribution to journal › Article

  434. The chemical synthesis of bioactive glycosylphosphatidylinositols from Trypanosoma cruzi containing an unsaturated fatty acid in the lipid

    Yashunsky, D. V., Borodkin, V. S., Ferguson, M. A. J. & Nikolaev, A. V. 2006 In : Angewandte Chemie International Edition. 45, 3, p. 468-474, 7 p.

    Research output: Contribution to journal › Article

  435. The proteome of Trypanosoma cruzi shed vesicles involved in host immuno modulation and cell invasion

    Nakayasu, E. S., Torrecilhas, A. C. T., Gozzo, F., Nohara, L. L., Lamont, D., Alves, M. J. M., Ferguson, M. A. J. & Almeida, I. C. 2006 In : FASEB Journal. 20, 4, p. A514-A514, 1 p., 346.5

    Research output: Contribution to journal › Meeting abstract

  436. Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter

    Stewart, M. L., Boussard, C., Brun, R., Gilbert, I. H. & Barrett, M. P. Dec-2005 In : Antimicrobial Agents and Chemotherapy. 49, 12, p. 5169-5171, 3 p.

    Research output: Contribution to journal › Article

  437. Phosphorus composition of sheep feces and changes in the field determined by 31P NMR spectroscopy and XRPD

    Shand, C. A., Coutts, G., Hillier, S., Lumsdon, D. G., Chudek, S. & Eubeler, J. Dec-2005 In : Environmental Science & Technology. 39, 23, p. 9205-9210, 6 p.

    Research output: Contribution to journal › Article

  438. An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential

    Dixon, M. J., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M. 1-Nov-2005 In : Bioorganic & Medicinal Chemistry Letters. 15, 21, p. 4717-4721, 5 p.

    Research output: Contribution to journal › Article

  439. Deletion of the glucosidase II gene in Trypanosoma brucei reveals novel N-glycosylation mechanisms in the biosynthesis of variant surface glycoprotein

    Jones, D. C., Mehlert, A., Guther, M. L. S. & Ferguson, M. A. J. 28-Oct-2005 In : Journal of Biological Chemistry. 280, 43, p. 35929-35942, 14 p.

    Research output: Contribution to journal › Article

  440. Synthesis of a cell-permeable analogue of a glycosylphosphatidylinositol (GPI) intermediate that is toxic to the living bloodstream form of Trypanosoma brucei

    Crossman, A., Smith, T. K., Ferguson, M. A. J. & Brimacombe, J. S. 24-Oct-2005 In : Tetrahedron Letters. 46, 43, p. 7419-7421, 3 p.

    Research output: Contribution to journal › Article

  441. Natural product family 18 chitinase inhibitors

    Andersen, O. A., Dixon, M. J., Eggleston, I. M. & van Aalten, D. M. F. 1-Oct-2005 In : Natural Product Reports. 22, 5, p. 563-579, 17 p.

    Research output: Contribution to journal › Article

  442. Here be dragons: docking and screening in an uncharted region of chemical space

    Brenk, R., Irwin, J. J. & Shoichet, B. K. Oct-2005 In : Journal of Biomolecular Screening. 10, 7, p. 667-674, 8 p.

    Research output: Contribution to journal › Article

  443. Structure and reactivity of hydroxypropylphosphonic acid epoxidase in fosfomycin biosynthesis by a cation- and flavin-dependent mechanism

    McLuskey, K., Cameron, S., Hammerschmidt, F., Hunter, W. N. & Davies, D. R. (ed.) Oct-2005 In : Proceedings of the National Academy of Sciences of the United States of America. 102, 40, p. 14221-14226, 6 p.

    Research output: Contribution to journal › Article

  444. Preparation of transition-state analogues of sterol 24-methyl transferase as potential anti-parasities

    Lorente, S. O., Jimenez, C. J., Gros, L., Yardley, V., de Luca-Fradley, K., Croft, S. L., Urbina, J. A., Ruiz-Perez, L. M., Pacanowska, D. G. & Gilbert, I. H. 15-Sep-2005 In : Bioorganic & Medicinal Chemistry. 13, 18, p. 5435-5453, 19 p.

    Research output: Contribution to journal › Article

  445. Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes

    Rao, F. V., Andersen, O. A., Vora, K. A., DeMartino, J. A. & van Aalten, D. M. F. 1-Sep-2005 In : Chemistry & Biology. 12, 9, p. 973-980, 8 p.

    Research output: Contribution to journal › Article

  446. Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites

    Baliani, A., Bueno, G. J., Stewart, M. L., Yardley, V., Brun, R., Barrett, M. P. & Gilbert, I. H. Jul-2005 In : Journal of Medicinal Chemistry. 48, 17, p. 5570-5579, 10 p.

    Research output: Contribution to journal › Article

  447. Mannosamine can replace glucosamine in glycosylphosphatidylinositols of Plasmodium falciparum in vitro

    Azzouz, N., de Macedo, C. S., Ferguson, M. A. J., Smith, T. K. & Schwarz, R. T. Jul-2005 In : Molecular and Biochemical Parasitology. 142, 1, p. 12-24, 13 p.

    Research output: Contribution to journal › Article

  448. The N-acetyl-d-glucosaminylphosphatidylinositol De-N-acetylase of glycosylphosphatidylinositol biosynthesis is a zinc metalloenzyme

    Urbaniak, M. D., Crossman, A., Chang, T., Smith, T. K., van Aalten, D. M. F. & Ferguson, M. A. J. 17-Jun-2005 In : Journal of Biological Chemistry. 280, 24, p. 22831-22838, 8 p.

    Research output: Contribution to journal › Article

  449. The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number

    Roper, J. R., Guther, M. L. S., MacRae, J. I., Prescott, A. R., Hallyburton, I., Acosta-Serrano, A. & Ferguson, M. A. J. 20-May-2005 In : Journal of Biological Chemistry. 280, 20, p. 19728-19736, 9 p.

    Research output: Contribution to journal › Article

  450. Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa

    Lorente, S. O., Gomez, R., Jimenez, C., Cammerer, S., Yardley, V., de Luca-Fradley, K., Croft, S. L., Perez, L. M. R., Urbina, J., Pacanowska, D. G. & Gilbert, I. H. 16-May-2005 In : Bioorganic & Medicinal Chemistry. 13, 10, p. 3519-3529, 11 p.

    Research output: Contribution to journal › Article

  451. 2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: identification, stereochemistry and initial SAR

    Wyatt, P. G., Allen, M. J., Borthwick, A. D., Davies, D. E., Exall, A. M., Hatley, R. J. D., Irving, W. R., Livermore, D. G., Miller, N. D., Nerozzi, F., Sollis, S. L. & Szardenings, A. K. May-2005 In : Bioorganic & Medicinal Chemistry Letters. 15, 10, p. 2579-2582, 4 p.

    Research output: Contribution to journal › Article

  452. Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase

    Khabnadideh, S., Pez, D., Musso, A., Brun, R., Perez, L. M. R., Gonzalez-Pacanowska, D. & Gilbert, I. H. 1-Apr-2005 In : Bioorganic & Medicinal Chemistry. 13, 7, p. 2637-2649, 13 p.

    Research output: Contribution to journal › Article

  453. Structural characterization of NETNES, a novel glycoconjugate in Trypanosoma cruzi epimastigotes

    MacRae, J. I., Acosta-Serrano, A., Morrice, N. A., Mehlert, A. & Ferguson, M. A. J. 1-Apr-2005 In : Journal of Biological Chemistry. 280, 13, p. 12201-12211, 11 p.

    Research output: Contribution to journal › Article

  454. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

    McManus, E. J., Sakamoto, K., Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R. & Alessi, D. R. Apr-2005 In : The EMBO Journal. 24, 8, p. 1571-1583, 13 p.

    Research output: Contribution to journal › Article

  455. A robust and selective method for the quantification of glycosylphosphatidylinositols in biological samples

    MacRae, J. I. & Ferguson, M. A. J. Feb-2005 In : Glycobiology. 15, 2, p. 131-138, 8 p.

    Research output: Contribution to journal › Article

  456. dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors

    Whittingham, J. L., Leal, I., Nguyen, C., Kasinathan, G., Bell, E., Jones, A. F., Berry, C., Benito, A., Turkenburg, J. P., Dodson, E. J., Ruiz Perez, L. M., Wilkinson, A. J., Johansson, N. G., Brun, R., Gilbert, I. H., Gonzalez Pacanowska, D. & Wilson, K. S. Feb-2005 In : Structure. 13, 2, p. 329-338, 10 p.

    Research output: Contribution to journal › Article

  457. Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence

    Munro, C. A., Bates, S., Buurman, E. T., Hughes, H. B., MacCallum, D. M., Bertram, G., Atrih, A., Ferguson, M. A. J., Bain, J. M., Brand, A., Hamilton, S., Westwater, C., Thomson, L. M., Brown, A. J. P., Odds, F. C. & Gow, N. A. R. 14-Jan-2005 In : Journal of Biological Chemistry. 280, 2, p. 1051-1060, 10 p.

    Research output: Contribution to journal › Article

  458. Trypanosoma brucei glycoproteins contain novel giant poly-N-acetyllactosamine carbohydrate chains

    Atrih, A., Richardson, J. M., Prescott, A. R. & Ferguson, M. A. J. 14-Jan-2005 In : Journal of Biological Chemistry. 280, 2, p. 865-871, 7 p.

    Research output: Contribution to journal › Article

  459. Analogues of thiolactomycin as potential antimalarial agents

    Jones, S. M., Urch, J. E., Kaiser, M., Brun, R., Harwood, J. L., Berry, C. & Gilbert, I. H. Jan-2005 In : Journal of Medicinal Chemistry. 48, 19, p. 5932-5941, 10 p.

    Research output: Contribution to journal › Article

  460. The identification of isoprenoids that bind in the intersubunit cavity of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase by complementary biophysical methods

    Kemp, L. E., Alphey, M. S., Bond, C. S., Ferguson, M. A. J., Hecht, S., Bacher, A., Eisenreich, W., Rohdich, F. & Hunter, W. N. Jan-2005 In : Acta Crystallographica Section D: Biological Crystallography. 61, 1, p. 45-52, 8 p.

    Research output: Contribution to journal › Article

  461. Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target

    Nguyen, C., Kasinathan, G., Leal-Cortijo, I., Musso-Buendia, A., Kaiser, M., Brun, R., Ruiz-Perez, L. M., Johansson, N. G., Gonzalez-Pacanowska, D. & Gilbert, I. H. 2005 In : Journal of Medicinal Chemistry. 48, 19, p. 5942-5954, 13 p.

    Research output: Contribution to journal › Article

  462. Discovery of non-steroidal mifepristone mimetics: pyrazoline-based PR antagonists

    Jones, D. G., Liang, X., Stewart, E. L., Noe, R. A., Kallander, L. S., Madauss, K. P., Williams, S. P., Thompson, S. K., Gray, D. W. & Hoekstra, W. J. 2005 In : Bioorganic & Medicinal Chemistry Letters. 15, 13, p. 3203-6, 4 p.

    Research output: Contribution to journal › Article

  463. Evaluation of cell-based assays for steroid nuclear receptors delivered by recombinant baculoviruses

    Katso, R. M., Parham, J. H., Caivano, M., Clay, W. C., Condreay, J. P., Gray, D. W., Lindley, K. M., Mason, S. J., Rieger, J., Wakes, N. C., Cairns, W. J. & Merrihew, R. V. 2005 In : Journal of Biomolecular Screening. 10, 7, p. 715-24, 10 p.

    Research output: Contribution to journal › Article

  464. Nucleobase participation in ribozyme catalysis

    Zhao, Z., McLeod, A., Harusawa, S., Araki, L., Yamaguchi, M., Kurihara, T. & Lilley, D. M. J. 2005 In : Journal of the American Chemical Society. 127, 14, p. 5026-5027, 2 p.

    Research output: Contribution to journal › Article

  465. Stereospecific effects determine the structure of a four-way DNA junction

    Liu, J., Déclais, A-C., McKinney, S. A., Ha, T., Norman, D. G. & Lilley, D. M. J. 2005 In : Chemistry & Biology. 12, 2, p. 217-228, 12 p.

    Research output: Contribution to journal › Article

  466. Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor

    Blair, D. E., Schuettelkopf, A. W., MacRae, J. I., van Aalten, D. M. F. & Thornton, J. (ed.) 2005 In : Proceedings of the National Academy of Sciences of the United States of America. 102, 43, p. 15429-15434, 6 p.

    Research output: Contribution to journal › Article

  467. Synthesis of an IGD peptidomimetic with motogenic activity

    Shpiro, N., Ellis, I. R., Dines, T. J., Schor, A. M., Schor, S. L., Norman, D. G. & Marquez, R. 2005 In : Molecular BioSystems. 1, 4, p. 318-320, 3 p.

    Research output: Contribution to journal › Article

  468. Synthetic fragments of antigenic lipophosphoglycans from Leishmania major and Leishmania mexicana and their use for characterisation of the Leishmania elongating alpha-D-mannopyranosylphosphate transferase

    Higson, A. P., Ross, A. J., Tsvetkov, Y. E., Routier, F. H., Sizova, O. V., Ferguson, M. A. J. & Nikolaev, A. V. 2005 In : Chemistry: a European Journal. 11, 7, p. 2019-2030, 12 p.

    Research output: Contribution to journal › Article

  469. The genome of the African trypanosome Trypanosoma brucei

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    Research output: Contribution to journal › Article

  470. In vitro biosynthesis of glycosylphosphatidylinositol in Aspergillus fumigatus

    Fontaine, T., Smith, T. K., Crossman, A., Brimacombe, J. S., Latge, J-P. & Ferguson, M. A. J. 7-Dec-2004 In : Biochemistry. 43, 48, p. 15267-15275, 9 p.

    Research output: Contribution to journal › Article

  471. Navigating chemical space for biology and medicine

    Lipinski, C. & Hopkins, A. Dec-2004 In : Nature. 432, 7019, p. 855-861, 7 p.

    Research output: Contribution to journal › Article

  472. Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness

    Smith, T. K., Crossman, A., Brimacombe, J. S. & Ferguson, M. A. J. Nov-2004 In : The EMBO Journal. 23, 23, p. 4701-4708, 8 p.

    Research output: Contribution to journal › Article

  473. Functional pharmacology of human prostanoid EP2 and EP4 receptors

    Wilson, R. J., Rhodes, S. A., Wood, R. L., Shield, V. J., Noel, L. S., Gray, D. W. & Giles, H. 6-Oct-2004 In : European Journal of Pharmacology. 501, 1-3, p. 49-58, 10 p.

    Research output: Contribution to journal › Article

  474. 6-phosphogluconate dehydrogenase: A target for drugs in African trypanosomes

    Hanau, S., Rinaldi, E., Dallocchio, F., Gilbert, I. H., Dardonville, C., Adams, M. J., Gover, S. & Barrett, M. P. Oct-2004 In : Current Topics in Medicinal Chemistry. 11, 19, p. 2639-2650, 12 p.

    Research output: Contribution to journal › Scientific review

  475. Mechanical stress induces profound remodelling of keratin filaments and cell junctions in epidermolysis bullosa simplex keratinocytes

    Russell, D., Andrews, P. D., James, J. & Lane, E. B. Oct-2004 In : Journal of Cell Science. 117, 22, p. 5233-5243, 11 p.

    Research output: Contribution to journal › Article

  476. The N-glycan glucosidase system in Trypanosom brucei

    Jones, D., Mehlert, A. & Ferguson, M. A. J. Oct-2004 In : Biochemical Society Transactions. 32, 5, p. 766-768, 3 p.

    Research output: Contribution to journal › Article

  477. Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element

    Finlay, D., Patel, S., Dickson, L. M., Shpiro, N., Marquez, R., Rhodes, C. J. & Sutherland, C. 6-Sep-2004 In : BMC Molecular Biology. 5, p. -, 13 p., 15

    Research output: Contribution to journal › Article

  478. Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis

    Lorente, S. O., Rodrigues, J. C. F., Jimenez, C. J., Joyce-Menekse, M., Rodrigues, C., Croft, S. L., Yardley, V., de Luca-Fradley, K., Ruiz-Perez, L. M., Urbina, J., de Souza, W., Pacanowska, D. G. & Gilbert, I. H. Aug-2004 In : Antimicrobial Agents and Chemotherapy. 48, 8, p. 2937-2950, 14 p.

    Research output: Contribution to journal › Article

  479. Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues

    Dardonville, C., Rinaldi, E., Barrett, M. P., Brun, R., Gilbert, I. H. & Hanau, S. 17-Jun-2004 In : Journal of Medicinal Chemistry. 47, 13, p. 3427-3437, 11 p.

    Research output: Contribution to journal › Article

  480. Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosis

    Hutchins, J. R. A., Moore, W. J., Hood, F. E., Wilson, J. S. J., Andrews, P. D., Swedlow, J. R. & Clarke, P. R. Jun-2004 In : Current Biology. 14, 12, p. 1099-1104, 6 p.

    Research output: Contribution to journal › Article

  481. Design, synthesis and evaluation of potential inhibitors of HIV gp120-CD4 interactions

    Boussard, C., Klimkait, T., Mahmood, N., Pritchard, M. & Gilbert, I. H. 17-May-2004 In : Bioorganic & Medicinal Chemistry Letters. 14, 10, p. 2673-2676, 4 p.

    Research output: Contribution to journal › Article

  482. Surface sialic acids taken from the host allow trypanosome survival in Tsetse fly vectors

    Nagamune, K., Acosta-Serrano, A., Uemura, H., Brun, R., Kunz-Renggli, C., Maeda, Y., Ferguson, M. A. J. & Kinoshita, T. 17-May-2004 In : Journal of Experimental Medicine. 199, 10, p. 1445-1450, 6 p.

    Research output: Contribution to journal › Article

  483. The surface coat of the mammal-dwelling infective trypomastigote stage of Trypanosoma cruzi is formed by highly diverse immunogenic mucins

    Buscaglia, C. A. ., Campo, V. A., Di Noia, J. M., Torrecilhas, A. C. T., De Marchi, C. R., Ferguson, M. A. J., Frasch, A. C. C. & Almeida, I. C. 16-Apr-2004 In : Journal of Biological Chemistry. 279, 16, p. 15860-15869, 10 p.

    Research output: Contribution to journal › Article

  484. Crystallographic study of inhibitors of tRNA-guanine transglycosylase suggests a new structure-based pharmacophore for virtual screening

    Brenk, R., Meyer, E. A., Reuter, K., Stubbs, M. T., Garcia, G. A., Diederich, F. & Klebe, G. Apr-2004 In : Journal of Molecular Biology. 338, 1, p. 55-75, 21 p.

    Research output: Contribution to journal › Article

  485. Sphingolipid-free Leishmania are defective in membrane trafficking, differentiation and infectivity

    Denny, P. W., Goulding, D., Ferguson, M. A. J. & Smith, D. F. Apr-2004 In : Molecular Microbiology. 52, 2, p. 313-327, 15 p.

    Research output: Contribution to journal › Article

  486. The chirality of a four-way helical junction in RNA

    Goody, T. A., Lilley, D. M. J. & Norman, D. G. Mar-2004 In : Journal of the American Chemical Society. 126, 13, p. 4126-4127, 2 p.

    Research output: Contribution to journal › Article

  487. Analogues of thiolactomycin as potential anti-malarial and anti-trypanosomal agents

    Jones, S. M., Urch, J. E., Brun, R., Harwood, J. L., Berry, C. & Gilbert, I. H. 15-Feb-2004 In : Bioorganic & Medicinal Chemistry. 12, 4, p. 683-692, 10 p.

    Research output: Contribution to journal › Article

  488. Aurora B regulates MCAK at the mitotic centromere

    Andrews, P. D., Ovechkina, Y., Morrice, N., Wagenbach, M., Duncan, K., Wordeman, L. & Swedlow, J. R. Feb-2004 In : Developmental Cell. 6, 2, p. 253-268, 16 p.

    Research output: Contribution to journal › Article

  489. A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major

    Vickers, T. J., Greig, N. & Fairlamb, A. H. 2004 In : Proceedings of the National Academy of Sciences. 101, 36, p. 13186-13191, 6 p.

    Research output: Contribution to journal › Article

  490. CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

    Scott, J. W., Hawley, S. A., Green, K. A., Anis, M., Stewart, G., Scullion, G. A., Norman, D. G. & Hardie, D. G. 2004 In : Journal of Clinical Investigation. 113, 2, p. 274-284, 11 p.

    Research output: Contribution to journal › Article

  491. Crystal structure of MO25 in complex with the C terminus of the pseudo kinase STE20-related adaptor

    Milburn, C. C., Boudeau, J., Deak, M., Alessi, D. R. & van Aalten, D. M. F. 2004 In : Nature Structural & Molecular Biology. 11, 2, p. 193-200, 8 p.

    Research output: Contribution to journal › Article

  492. Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1

    Hopkins, A. L., Ren, J., Milton, J., Hazen, R. J., Chan, J. H., Stuart, D. I. & Stammers, D. K. 2004 In : Journal of Medicinal Chemistry. 47, 24, p. 5912-5922, 11 p.

    Research output: Contribution to journal › Article

  493. Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani

    Wyllie, S., Cunningham, M. L. & Fairlamb, A. H. 2004 In : Journal of Biological Chemistry. 279, 38, p. 39925-39932, 8 p.

    Research output: Contribution to journal › Article

  494. Non spiral and spiral (helical) flow patterns in stenoses. In vitro observations using spin and gradient echo magnetic resonance imaging (MRI) and computational fluid dynamic modeling

    Stonebridge, P. A., Buckley, C., Thompson, A., Dick, J., Hunter, G., Chudek, J. A., Houston, J. G. & Belch, J. J. F. 2004 In : International Angiology. 23, 3, p. 276-283, 8 p.

    Research output: Contribution to journal › Article

  495. Phosphatidylinositol 3-kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients

    James, M. J. & Zomerdijk, J. C. B. M. 2004 In : Journal of Biological Chemistry. 279, 10, p. 8911-8918, 8 p.

    Research output: Contribution to journal › Article

  496. Sensing of remote oxyanion binding at the DNA binding domain of the molybdate-dependent transcriptional regulator, ModE

    Boxer, D. H., Zhang, H., Gourley, D. G., Hunter, W. N., Kelly, S. M. & Price, N. C. 2004 In : Organic and Biomolecular Chemistry. 2, 19, p. 2829-2837, 9 p.

    Research output: Contribution to journal › Article

  497. Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo

    Thompson, A. M. & 23 others Spruce, B. A., Campbell, L. A., McTavish, N., Cooper, M. A., Appleyard, M. V. L., O'Neill, M., Howie, J., Samson, J., Watt, S., Murray, K., McLean, D., Leslie, N. R., Safrany, S. T., Ferguson, M. J., Peters, J. A., Prescott, A. R., Box, G., Hayes, A., Nutley, B., Raynaud, F., Downes, C. P., Lambert, J. J. & Eccles, S. 2004 In : Cancer Research. 64, 1, p. 4875-4886, 12 p.

    Research output: Contribution to journal › Article

  498. Structure-based exploration of cyclic dipeptide chitinase inhibitors

    Houston, D. R., Synstad, B., Eijsink, V. G. H., Stark, M. J. R., Eggleston, I. M. & van Aalten, D. M. F. 2004 In : Journal of Medicinal Chemistry. 47, 23, p. 5713-20, 8 p.

    Research output: Contribution to journal › Article

  499. Synthesis of analogues of Congo red and evaluation of their anti-prion activity

    Sellarajah, S., Lekishvili, T., Bowring, C., Thompsett, A. R., Rudyk, H., Birkett, C. R., Brown, D. R. & Gilbert, I. H. 2004 In : Journal of Medicinal Chemistry. 47, 22, p. 5515-5534, 20 p.

    Research output: Contribution to journal › Article

  500. Synthesis of potential bisubstrate inhibitors of Leishmania elongating α-d-mannosyl phosphate transferase

    Borodkin, V. S., Ferguson, M. A. J. & Nikolaev, A. V. 2004 In : Tetrahedron Letters. 45, 4, p. 857-862, 6 p.

    Research output: Contribution to journal › Article

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