Discovery - University of Dundee - Online Publications

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Biological Chemistry and Drug Discovery

  1. Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity

    Sola, I., Castellà, S., Viayna, E., Galdeano, C., Taylor, M. C., Gbedema, S. Y., Pérez, B., Clos, M. V., Jones, D. C., Fairlamb, A. H., Wright, C. W., Kelly, J. M. & Muñoz-Torrero, D. 15 Aug 2015 In : Bioorganic & Medicinal Chemistry. 23, 16, p. 5156-5167 12 p.

    Research output: Contribution to journalArticle

  2. Bacillus anthracis meningitis during an outbreak of injectional anthrax, Scotland, UK

    Dewar, S., Weir-McCall, J. R., Batchelor, L., Cole, S. & Parcell, B. J. 1 Aug 2015 In : Clinical Microbiology and Infection. 21, 8, p. e49-e50 2 p.

    Research output: Contribution to journalArticle

  3. Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

    Kazlauskaite, A., Martínez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H. & Muqit, M. M. K. 1 Aug 2015 In : EMBO Reports. 16, 8, p. 939-954 16 p.

    Research output: Contribution to journalArticle

  4. Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma brucei

    McCulloch, R. & Field, M. C. Aug 2015 In : Trends in Parasitology. 31, 8, p. 346-349 4 p.

    Research output: Contribution to journalArticle

  5. Crystal structures reveal that the reaction mechanism of imidazoleglycerol-phosphate dehydratase is controlled by switching Mn(II) coordination

    Bisson, C., Britton, K. L., Sedelnikova, S. E., Rodgers, H. F., Eadsforth, T. C., Viner, R. C., Hawkes, T. R., Baker, P. J. & Rice, D. W. 7 Jul 2015 In : Structure. 23, 7, p. 1236-1245 10 p.

    Research output: Contribution to journalArticle

  6. N-myristoyltransferase is a cell wall target in Aspergillus fumigatus

    Fang, W., Robinson, D. A., Raimi, O. G., Blair, D. E., Harrison, J. R., Lockhart, D. E. A., Torrie, L. S., Ruda, G. F., Wyatt, P. G., Gilbert, I. H. & van Aalten, D. M. F. 19 Jun 2015 In : ACS Chemical Biology. 10, 6, p. 1425-1434 10 p.

    Research output: Contribution to journalArticle

  7. A novel multiple-stage antimalarial agent that inhibits protein synthesis

    Fairlamb, A. H. , Gilbert, I. H. & 61 others Baragana, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Almeida, M. J., Pradhan, A., Porzelle, A., Santos Martinez, M., Bolscher, J. M., Woodland, A., Norval, S., Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Belén Jiménez-Díaz, M., Maria Sanz, L., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Javier Gamo, F., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S., Marfurt, J., Price, R. N., Sinden, R. E., Winzeler, E. A., Charman, S. A., Bebrevska, L., Gray, D. W., Campbell, S., Willis, P. A., Rayner, J. C., Fidock, D. A. & Read, K. D. 18 Jun 2015 In : Nature. 522, 7556, p. 315-320 6 p.

    Research output: Contribution to journalArticle

  8. Application of RNAi to genomic drug target validation in schistosomes

    Guidi, A., Mansour, N. R., Paveley, R. A., Carruthers, I. M., Besnard, J., Hopkins, A. L., Gilbert, I. H. & Bickle, Q. D. 20 May 2015 In : PLoS Neglected Tropical Diseases. 9, 5, 22 p., e0003801

    Research output: Contribution to journalArticle

  9. Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

    Bulatov, E. & Ciulli, A. 1 May 2015 In : Biochemical Journal. 467, 3, p. 365-386 22 p.

    Research output: Contribution to journalArticle

  10. Crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major

    Barrack, K. L., Fyfe, P. K., Finney, A. J. & Hunter, W. N. May 2015 In : Molecular and Biochemical Parasitology. 201, 1, p. 26-30 5 p.

    Research output: Contribution to journalArticle

  11. Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase

    Robinson, D. A. & Wyatt, P. G. May 2015 In : Acta Crystallographica Section F: Structural Biology Communications. 71, 5, p. 586-593 8 p.

    Research output: Contribution to journalArticle

  12. Macromolecular crystallography and what it can contribute to antiparasite drug discovery

    Hunter, W. N. & Weiss, M. S. May 2015 In : Acta Crystallographica Section F: Structural Biology Communications. 71, 5, p. 483-484 2 p.

    Research output: Contribution to journalEditorial

  13. Identification of caveolar resident proteins in ventricular myocytes using a quantitative proteomic approach: dynamic changes in caveolar composition following adrenoceptor activation

    Wypijewski, K. J., Tinti, M., Chen, W., Lamont, D., Ashford, M. L. J., Calaghan, S. C. & Fuller, W. Mar 2015 In : Molecular & Cellular Proteomics. 14, 3, p. 596-608 13 p.

    Research output: Contribution to journalArticle

  14. Decreased adipogenesis and adipose tissue in mice with inactivated protein phosphatase 5

    Jacob, W., Rosenzweig, D., Vázquez-Martin, C., Duce, S. L. & Cohen, P. T. W. 15 Feb 2015 In : Biochemical Journal. 466, 1, p. 163-176 14 p.

    Research output: Contribution to journalArticle

  15. Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

    Henderson, C. J., McLaughlin, L. A., Osuna-Cabello, M., Taylor, M., Gilbert, I., McLaren, A. W. & Wolf, C. R. 1 Feb 2015 In : Biochemical Journal. 465, 3, p. 479-488 10 p.

    Research output: Contribution to journalArticle

  16. The Joint European Compound Library: boosting precompetitive research

    Besnard, J., Jones, P. S., Hopkins, A. L. & Pannifer, A. D. Feb 2015 In : Drug Discovery Today. 20, 2, p. 181-186 6 p.

    Research output: Contribution to journalArticle

  17. TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

    Fairlamb, A. H. , Ferguson, M. A. J. & 39 others Shameer, S., Logan-Klumpler, F. J., Vinson, F., Cottret, L., Merlet, B., Achcar, F., Boshart, M., Berriman, M., Breitling, R., Bringaud, F., Bütikofer, P., Cattanach, A. M., Bannerman-Chukualim, B., Creek, D. J., Crouch, K., de Koning, H. P., Denise, H., Ebikeme, C., Ginger, M. L., Hertz-Fowler, C., Kerkhoven, E. J., Mäser, P., Michels, P. A. M., Nayak, A., Nes, D. W., Nolan, D. P., Olsen, C., Silva-Franco, F., Smith, T. K., Taylor, M. C., Tielens, A. G. M., Urbaniak, M. D., van Hellemond, J. J., Vincent, I. M., Wilkinson, S. R., Wyllie, S., Opperdoes, F. R., Barrett, M. P. & Jourdan, F. 28 Jan 2015 In : Nucleic Acids Research. 43, D1, p. D637-D644 8 p.

    Research output: Contribution to journalArticle

  18. Crystals on the cover 2015

    Einspahr, H., Weiss, M. S. & Hunter, W. N. Jan 2015 In : Acta Crystallographica Section F: Structural Biology Communications. F71, 1, p. 1-2 2 p.

    Research output: Contribution to journalArticle

  19. Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes

    Glover, L., Alsford, S., Baker, N., Turner, D. J., Sanchez-Flores, A., Hutchinson, S., Hertz-Fowler, C., Berriman, M. & Horn, D. Jan 2015 In : Nature Protocols. 10, 1, p. 106-33 28 p.

    Research output: Contribution to journalArticle

  20. 14-3-3-Pred: Improved methods to predict 14-3-3-binding phosphopeptides

    Madeira, F., Tinti, M., Murugesan, G., Berrett, E., Stafford, M., Toth, R., Cole, C., MacKintosh, C. & Barton, G. J. 2015 In : Bioinformatics.

    Research output: Contribution to journalArticle

  21. Arsenic exposure and outcomes of antimonial treatment in visceral leishmaniasis patients in bihar, India: a retrospective cohort study

    Perry, M. R., Prajapati, V. K., Menten, J., Raab, A., Feldmann, J., Chakraborti, D., Sundar, S., Fairlamb, A. H., Boelaert, M. & Picado, A. 2015 In : PLoS Neglected Tropical Diseases. 9, 3, 17 p., e0003518

    Research output: Contribution to journalArticle

  22. ENTH and ANTH domain proteins participate in AP2-independent clathrin-mediated endocytosis

    Manna, P. T., Gadelha, C., Puttick, A. E. & Field, M. C. 2015 In : Journal of Cell Science. 128, 11, p. 2130-2142 13 p.

    Research output: Contribution to journalArticle

  23. Identification of a glycosylphosphatidylinositol anchor-modifying β1-3 galactosyltransferase in Trypanosoma brucei

    Izquierdo, L., Acosta-Serrano, A., Mehlert, A. & Ferguson, M. A. J. 2015 In : Glycobiology. 25, 4, p. 438-447 50 p.

    Research output: Contribution to journalArticle

  24. New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource

    Peña, I. , Pilar Manzano, M. , Cantizani, J. , Kessler, A. , Alonso-Padilla, J. , Bardera, A. I. , Alvarez, E. , Colmenarejo, G. , Cotillo, I. , Roquero, I. , de Dios-Anton, F. , Barroso, V. , Rodriguez, A. , Gray, D. W. , Navarro, M. , Kumar, V. , Sherstnev, A. , Drewry, D. H. , Brown, J. R. , Fiandor, J. M. & 1 others Julio Martin, J. 2015 In : Scientific Reports. 5, 12 p., 8771

    Research output: Contribution to journalArticle

  25. Surface plasmon resonance analysis of seven-transmembrane receptors

    Aristotelous, T., Hopkins, A. L. & Navratilova, I. 2015 Membrane Proteins—Production and Functional Characterization. Shukla, A. K. (ed.). Academic Press, p. 499-525 27 p. (Methods in Enzymology; vol. 556)

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  26. PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia

    Mudie, S., Bandarra, D., Batie, M., Biddlestone, J., Moniz, S., Ortmann, B., Shmakova, A. & Rocha, S. 15 Dec 2014 In : Cell Cycle. 13, 24, p. 3878-3891 14 p.

    Research output: Contribution to journalArticle

  27. O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signalling?

    Alonso , J., Schimpl, M. & van Aalten, D. M. F. 12 Dec 2014 In : Journal of Biological Chemistry. 289, 50, p. 34433-34439 7 p.

    Research output: Contribution to journalArticle

  28. Evolutionary cell biology: two origins, one objective

    Lynch, M., Field, M. C., Goodson, H. V., Malik, H. S., Pereira-Leal, J. B., Roos, D. S., Turkewitz, A. P. & Sazer, S. 2 Dec 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 48, p. 16990-16994 5 p.

    Research output: Contribution to journalArticle

  29. Disposition and metabolic profiling of [14C]cerlapirdine using accelerator mass spectrometry

    Tse, S., Leung, L., Raje, S., Seymour, M., Shishikura, Y. & Obach, R. S. Dec 2014 In : Drug Metabolism and Disposition. 42, 12, p. 2023-2032 10 p.

    Research output: Contribution to journalArticle

  30. Erratum for De Rycker et al., comparison of a high-throughput high-content intracellular leishmania donovani assay with an axenic amastigote assay

    De Rycker, M., Hallyburton, I., Thomas, J., Campbell, L., Wyllie, S., Joshi, D., Cameron, S., Gilbert, I. H., Wyatt, P. G., Frearson, J. A., Fairlamb, A. H. & Gray, D. W. Dec 2014 In : Antimicrobial Agents and Chemotherapy. 58, 12, p. 7622 1 p.

    Research output: Contribution to journalArticle

  31. GEN1 from a thermophilic fungus is functionally closely similar to non-eukaryotic junction-resolving enzymes

    Freeman, A. D. J., Liu, Y., Déclais, A-C., Gartner, A. & Lilley, D. M. J. Dec 2014 In : Journal of Molecular Biology. 426, 24, p. 3946-3959 14 p.

    Research output: Contribution to journalArticle

  32. The times they are a-changin' - news from Acta Crystallographica Section F

    Hunter, W. N. & Weiss, M. S. Dec 2014 In : Acta Crystallographica Section F: Structural Biology Communications. 70, 12, p. 1575 1 p., F70

    Research output: Contribution to journalEditorial

  33. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

    Bago, R., Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G. & Alessi, D. R. Nov 2014 In : Biochemical Journal. 463, 3, p. 413-427 15 p.

    Research output: Contribution to journalArticle

  34. Fragment screening by SPR and advanced application to GPCRs

    Shepherd, C. A., Hopkins, A. L. & Navratilova, I. Nov 2014 In : Progress in Biophysics and Molecular Biology. 116, 2-3, p. 113-123 11 p.

    Research output: Contribution to journalArticle

  35. NMR approaches in structure-based lead discovery: recent developments and new frontiers for targeting multi-protein complexes

    Dias, D. M. & Ciulli, A. Nov 2014 In : Progress in Biophysics and Molecular Biology. 116, 2-3, p. 101-112 12 p.

    Research output: Contribution to journalArticle

  36. Respiratory flexibility in response to inhibition of cytochrome c oxidase in Mycobacterium tuberculosis

    Arora, K., Ochoa-Montaño, B., Tsang, P. S., Blundell, T. L., Dawes, S. S., Mizrahi, V., Bayliss, T., Mackenzie, C. J., Cleghorn, L. A. T., Ray, P. C., Wyatt, P. G., Uh, E., Lee, J., Barry, C. E. & Boshoff, H. I. Nov 2014 In : Antimicrobial Agents and Chemotherapy. 58, 11, p. 6962-6965 4 p.

    Research output: Contribution to journalArticle

  37. The mitochondrial respiratory chain of the secondary green alga Euglena gracilis shares many additional subunits with parasitic Trypanosomatidae

    Perez, E., Lapaille, M., Degand, H., Cilibrasi, L., Villavicencio-Queijeiro, A., Morsomme, P., González-Halphen, D., Field, M. C., Remacle, C., Baurain, D. & Cardol, P. Nov 2014 In : Mitochondrion. 19 Pt B, p. 338-49 12 p.

    Research output: Contribution to journalArticle

  38. The spatial effect of protein deuteration on nitroxide spin-label relaxation: implications for EPR distance measurement

    El Mkami, H., Ward, R., Bowman, A., Owen-Hughes, T. & Norman, D. G. Nov 2014 In : Journal of Magnetic Resonance . 248, p. 36-41 6 p.

    Research output: Contribution to journalArticle

  39. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes

    Baud, M. G. J., Lin-Shiao, E., Cardote, T., Tallant, C., Pschibul, A., Chan, K-H., Zengerle, M., Garcia, J. R., Kwan, T. T-L., Ferguson, F. M. & Ciulli, A. 31 Oct 2014 In : Science. 346, 6209, p. 638-641 4 p.

    Research output: Contribution to journalArticle

  40. Binding hotspots of BAZ2B bromodomain: histone interaction revealed by solution NMR driven docking

    Ferguson, F. M., Dias, D. M., Rodrigues, J. P. G. L. M., Wienk, H., Boelens, R., Bonvin, A. M. J. J., Abell, C. & Ciulli, A. 28 Oct 2014 In : Biochemistry. 53, 42, p. 6706-6716 11 p.

    Research output: Contribution to journalArticle

  41. Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities

    Galdeano , C., Gadd, M. S., Soares, P., Scaffidi, S., Van Molle, I., Birced, I., Hewitt, S., Dias, D. M. & Ciulli, A. 23 Oct 2014 In : Journal of Medicinal Chemistry. 57, 20, p. 8657-8663 7 p.

    Research output: Contribution to journalArticle

  42. Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human African trypanosomiasis

    Giordani, F., Buschini, A., Baliani, A., Kaiser, M., Brun, R., Barrett, M. P., Pellacani, C., Poli, P. & Gilbert, I. H. Oct 2014 In : Antimicrobial Agents and Chemotherapy. 58, 10, p. 5747-5757 11 p.

    Research output: Contribution to journalArticle

  43. Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ES cell differentiation without affecting naive to primed cell transition

    Speakman, C. M., Domke, T. C. E., Wongpaiboonwattana, W., Sanders, K., Mudaliar, M., van Aalten, D. M. F., Barton, G. J. & Stavridis, M. P. Oct 2014 In : Stem Cells. 32, 10, p. 2605-2615

    Research output: Contribution to journalArticle

  44. Missing pieces of an ancient puzzle: evolution of the Eukaryotic Membrane-Trafficking System

    Schlacht, A., Herman, E. K., Klute, M. J., Field, M. C. & Dacks, J. B. Oct 2014 In : Cold Spring Harbor Perspectives in Biology. 6, 10, a016048

    Research output: Contribution to journalArticle

  45. The design and synthesis of potent and selective inhibitors of trypanosoma brucei glycogen synthase kinase 3 for the treatment of human African trypanosomiasis

    Urich, R., Grimaldi, R., Luksch, T., Frearson, J. A., Brenk, R. & Wyatt, P. G. 25 Sep 2014 In : Journal of Medicinal Chemistry. 57, 18, p. 7536-7549 14 p.

    Research output: Contribution to journalArticle

  46. Reproducible Automated Phosphopeptide Enrichment using Magnetic TiO2 and Ti-IMAC

    Tape, C. J., Worboys, J. D., Sinclair, J., Gourlay, R., Vogt, J., McMahon (Broster), K. M., Trost, M., Lauffenburger, D. A., Lamont, D. J. & Jørgensen, C. 18 Sep 2014 In : Analytical Chemistry. ASAP

    Research output: Contribution to journalArticle

  47. Fragment-Based Screening in Tandem with Phenotypic Screening Provides Novel Antiparasitic Hits

    Blaazer, A. R., Orrling, K. M., Shanmugham, A., Jansen, C., Maes, L., Edink, E., Sterk, G. J., Siderius, M., England, P., Bailey, D., de Esch, I. J. P. & Leurs, R. 17 Sep 2014 In : Journal of Biomolecular Screening.

    Research output: Contribution to journalArticle

  48. Loss of glial neurofascin155 delays developmental synapse elimination at the neuromuscular junction

    Roche, S. L., Sherman, D. L., Dissanayake, K., Soucy, G., Desmazieres, A., Lamont, D. J., Peles, E., Julien, J-P., Wishart, T. M., Ribchester, R. R., Brophy, P. J. & Gillingwater, T. H. 17 Sep 2014 In : Journal of Neuroscience. 34, 38, p. 12904-12918 15 p.

    Research output: Contribution to journalArticle

  49. Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile

    Díaz-Sáez, L., Srikannathasan, V., Zoltner, M. & Hunter, W. N. 15 Sep 2014 In : Biochemical Journal. 462, 3, p. 581-589 9 p.

    Research output: Contribution to journalArticle

  50. A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes

    Galvin, B. D., Li, Z., Villemaine, E., Poole, C. B., Chapman, M. S., Pollastri, M. P., Wyatt, P. G. & Carlow, C. K. S. Sep 2014 In : PLoS Neglected Tropical Diseases. 8, 9, 13 p., e3145

    Research output: Contribution to journalArticle

  51. ATP7B activity is stimulated by PKCɛ in porcine liver

    Cardoso, L. H. D., Britto Borges, T., Vieyra, A. & Lowe, J. Sep 2014 In : International Journal of Biochemistry & Cell Biology. 54, p. 60-67 8 p.

    Research output: Contribution to journalArticle

  52. Crystal structure and mechanistic investigation of the twister ribozyme

    Liu, Y., Wilson, T. J., McPhee, S. A. & Lilley, D. M. J. Sep 2014 In : Nature Chemical Biology. 10, 9, p. 739-744 6 p.

    Research output: Contribution to journalArticle

  53. Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains

    Kneuper, H., Cao, Z. P., Twomey, K. B., Zoltner, M., Jäger, F., Cargill, J. S., Chalmers, J., van der Kooi-Pol, M. M., van Dijl, J. M., Ryan, R. P., Hunter, W. N. & Palmer, T. Sep 2014 In : Molecular Microbiology. 93, 5, p. 928-943 15 p.

    Research output: Contribution to journalArticle

  54. Quantification of biliary excretion and sinusoidal excretion of 5(6)-carboxy-2',7'-dichlorofluorescein (CDF) in cultured hepatocytes isolated from Sprague Dawley, Wistar and Mrp2-deficient Wistar (TR-) rats

    Ellis, L. C. J., Grant, M. H., Hawksworth, G. M. & Weaver, R. J. Sep 2014 In : Toxicology in Vitro. 28, 6, p. 1165-1175 11 p.

    Research output: Contribution to journalArticle

  55. Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors

    Lockhart, D. E. A., Schuettelkopf, A., Blair, D. E. & van Aalten, D. M. F. 25 Aug 2014 In : FEBS Letters. 588, 17, p. 3282-3290 9 p.

    Research output: Contribution to journalArticle

  56. A structural and biochemical model of processive chitin synthesis

    Dorfmueller, H. C., Ferenbach, A. T., Borodkin, V. S. & van Aalten, D. M. F. 15 Aug 2014 In : Journal of Biological Chemistry. 289, p. 23020-23028 9 p.

    Research output: Contribution to journalArticle

  57. Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1

    Khalaf, A. I., Huggan, J. K., Suckling, C. J., Gibson, C. L., Stewart, K., Giordani, F., Barrett, M. P., Wong, P. E., Barrack, K. L. & Hunter, W. N. 14 Aug 2014 In : Journal of Medicinal Chemistry. 57, 15, p. 6479-6494 16 p.

    Research output: Contribution to journalArticle

  58. Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo

    Olivera-Martinez, I., Schurch, N., Li, R., Song, J., Halley, P. A., Das, R. M., Burt, D. W., Barton, G. J. & Storey, K. G. Aug 2014 In : Development. 141, 16, p. 3266-3276 11 p.

    Research output: Contribution to journalArticle

  59. Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human african trypanosomiasis

    Sullivan, L., Fleming, J., Sastry, L., Mehlert, A., Wall, S. J. & Ferguson, M. A. J. 17 Jul 2014 In : PLoS Neglected Tropical Diseases. 8, 7, p. e2976

    Research output: Contribution to journalArticle

  60. Molecular cloning and functional characterization of components of the capsule biosynthesis complex of Neisseria meningitidis serogroup A: toward in vitro vaccine production

    Fiebig, T., Freiberger, F., Pinto, V., Romano, M. R., Black, A., Litschko, C., Bethe, A., Yashunsky, D., Adamo, R., Nikolaev, A., Berti, F. & Gerardy-Schahn, R. 11 Jul 2014 In : Journal of Biological Chemistry. 289, 28, p. 19395-19407 13 p.

    Research output: Contribution to journalArticle

  61. Antigenic variation in African trypanosomes

    Horn, D. Jul 2014 In : Molecular and Biochemical Parasitology. 195, 2, p. 123-129 7 p.

    Research output: Contribution to journalArticle

  62. C-reactive protein is essential for innate resistance to pneumococcal infection

    Simons, J. P., Loeffler, J. M., Al-Shawi, R., Ellmerich, S., Hutchinson, W. L., Tennent, G. A., Petrie, A., Raynes, J. G., de Souza, J. B., Lawrence, R. A., Read, K. D. & Pepys, M. B. Jul 2014 In : Immunology. 142, 3, p. 414-420 7 p.

    Research output: Contribution to journalArticle

  63. Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

    Cole, C., Kroboth, K., Schurch, N. J., Sandilands, A., Sherstnev, A., O'Regan, G. M., Watson, R. M., McLean, W. H. I., Barton, G. J., Irvine, A. D. & Brown, S. J. Jul 2014 In : Journal of Allergy and Clinical Immunology. 134, 1, p. 82-91 10 p.

    Research output: Contribution to journalArticle

  64. Validity of ligand efficiency metrics

    Murray, C. W., Erlanson, D. A., Hopkins, A. L., Keserü, G. M., Leeson, P. D., Rees, D. C., Reynolds, C. H. & Richmond, N. J. 12 Jun 2014 In : ACS Medicinal Chemistry Letters. 5, 6, p. 616-618 3 p.

    Research output: Contribution to journalArticle

  65. Glycogen Synthase Kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells

    Sarshad, A. A., Corcoran, M., Al-Muzzaini, B., Borgonovo-Brandter, L., Von Euler, A., Lamont, D., Visa, N. & Percipalle, P. 5 Jun 2014 In : PLoS Genetics. 10, 6, 17 p., e1004390

    Research output: Contribution to journalArticle

  66. Evolution of the nucleus

    Devos, D. P., Gräf, R. & Field, M. C. Jun 2014 In : Current Opinion in Cell Biology. 28, p. 8-15 8 p.

    Research output: Contribution to journalArticle

  67. TbGT8 is a bifunctional glycosyltransferase that elaborates N-linked glycans on a protein phosphatase AcP115 and a GPI-anchor modifying glycan in Trypanosoma brucei

    Nakanishi, M., Karasudani, M., Shiraishi, T., Hashida, K., Hino, M., Ferguson, M. A. J. & Nomoto, H. Jun 2014 In : Parasitology International. 63, 3, p. 513-518 6 p.

    Research output: Contribution to journalArticle

  68. Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei

    Alsford, S., Currier, R. B., Guerra-Assunção, J. A., Clark, T. G. & Horn, D. 15 May 2014 In : PLoS Pathogens. 10, 5, 12 p., e1004130

    Research output: Contribution to journalArticle

  69. Nuclear pore complex evolution: a trypanosome Mlp analogue functions in chromosomal segregation but lacks transcriptional barrier activity

    Holden, J. M., Koreny, L., Obado, S., Ratushny, A. V., Chen, W-M., Chiang, J-H., Kelly, S., Chait, B. T., Aitchison, J. D., Rout, M. P. & Field, M. C. 1 May 2014 In : Molecular Biology of the Cell. 25, 9, p. 1421-1436 16 p.

    Research output: Contribution to journalArticle

  70. Life and times: synthesis, trafficking, and evolution of VSG

    Manna, P. T., Boehm, C., Leung, K. F., Natesan, S. K. & Field, M. C. May 2014 In : Trends in Parasitology. 30, 5, p. 251-258 8 p.

    Research output: Contribution to journalArticle

  71. The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma brucei

    Lilley, A. C., Major, L., Young, S., Stark, M. J. R. & Smith, T. K. May 2014 In : Molecular Microbiology. 92, 3, p. 453-470 18 p.

    Research output: Contribution to journalArticle

  72. Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase

    Roberts, A. J., Torrie, L. S., Wyllie, S. & Fairlamb, A. H. 15 Apr 2014 In : Biochemical Journal. 459, 2, p. 323-332 10 p.

    Research output: Contribution to journalArticle

  73. Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy

    Wishart, T. M. , Mutsaers, C. A. , Riessland, M. , Reimer, M. M. , Hunter, G. , Hannam, M. L. , Eaton, S. L. , Fuller, H. R. , Roche, S. L. , Somers, E. , Morse, R. , Young, P. J. , Lamont, D. J. , Hammerschmidt, M. , Joshi, A. , Hohenstein, P. , Morris, G. E. , Parson, S. H. , Skehel, P. A. , Becker, T. & 4 others Robinson, I. M., Becker, C. G., Wirth, B. & Gillingwater, T. H. 1 Apr 2014 In : Journal of Clinical Investigation. 124, 4, p. 1821-1834 14 p.

    Research output: Contribution to journalArticle

  74. A novel marker, ARM58, confers antimony resistance to Leishmania spp

    Nuhs, A., Schäfer, C., Zander, D., Trübe, L., Tejera Nevado, P., Schmidt, S., Arevalo, J., Adaui, V., Maes, L., Dujardin, J-C. & Clos, J. Apr 2014 In : International Journal for Parasitology: Drugs and Drug Resistance. 4, 1, p. 37-47 11 p.

    Research output: Contribution to journalArticle

  75. Structure of a rare non-standard sequence k-turn bound by L7Ae protein

    Huang, L. & Lilley, D. M. J. Apr 2014 In : Nucleic Acids Research. 42, 7, p. 4734-4740 7 p.

    Research output: Contribution to journalArticle

  76. The cell biology of the endocytic system from an evolutionary perspective

    Wideman, J. G., Leung, K. F., Field, M. C. & Dacks, J. B. Apr 2014 In : Cold Spring Harbor Perspectives in Biology. 6, 4, 12 p., a016998

    Research output: Contribution to journalArticle

  77. The k-junction motif in RNA structure

    Wang, J., Daldrop, P., Huang, L. & Lilley, D. M. J. Apr 2014 In : Nucleic Acids Research. 42, 8, p. 5322-5331 10 p.

    Research output: Contribution to journalArticle

  78. Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase

    Urbaniak, M. D., Capes, A. S., Crossman, A., O'Neill, S., Thompson, S., Gilbert, I. H. & Ferguson, M. A. J. 31 Mar 2014 In : Carbohydrate Research. 387, p. 54-58 5 p.

    Research output: Contribution to journalArticle

  79. Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei

    Damerow, M., Rodrigues, J. A., Wu, D., Güther, M. L. S., Mehlert, A. & Ferguson, M. A. J. 28 Mar 2014 In : Journal of Biological Chemistry. 289, 13, p. 9328-9339 12 p.

    Research output: Contribution to journalArticle

  80. How the structure of the large subunit controls function in an oxygen-tolerant [NiFe]-hydrogenase

    Bowman, L., Flanagan, L., Fyfe, P. K., Parkin, A., Hunter, W. N. & Sargent, F. 15 Mar 2014 In : Biochemical Journal. 458, 3, p. 449-458 10 p.

    Research output: Contribution to journalArticle

  81. High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei.

    McGregor, P., Ivens, A., Shave, S., Collie, I., Gray, D., Auer, M. & Matthews, K. R. Mar 2014 In : Eukaryotic Cell. 13, 3, p. 412-426 15 p.

    Research output: Contribution to journalArticle

  82. Predicting hydration free energies with chemical accuracy: the SAMPL4 challenge

    Sandberg, L. Mar 2014 In : Journal of Computer-Aided Molecular Design. 28, 3, p. 211-219 9 p.

    Research output: Contribution to journalArticle

  83. Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues

    Capes, A. S., Crossman, A., Urbaniak, M. D., Gilbert, S. H., Ferguson, M. A. J. & Gilbert, I. H. Mar 2014 In : Organic and Biomolecular Chemistry. 12, 12, p. 1919-1934 16 p.

    Research output: Contribution to journalArticle

  84. Norspermidine is not a self-produced trigger for biofilm disassembly

    Hobley, L., Kim, S. H., Maezato, Y., Wyllie, S., Fairlamb, A. H., Stanley-Wall, N. R. & Michael, A. J. 13 Feb 2014 In : Cell. 156, 4, p. 844-854 11 p.

    Research output: Contribution to journalArticle

  85. Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors

    Borodkin, V. S., Schimpl, M., Gundogdu, M., Rafie, K., Dorfmueller, H. C., Robinson, D. A. & van Aalten, D. M. F. 1 Feb 2014 In : Biochemical Journal. 457, 3, p. 497-502 6 p.

    Research output: Contribution to journalArticle

  86. High-resolution structure of the M14-type cytosolic carboxypeptidase from Burkholderia cenocepacia refined exploiting PDB_REDO strategies

    Rimsa, V., Eadsforth, T. C., Joosten, R. P. & Hunter, W. N. Feb 2014 In : Acta Crystallographica Section D: Biological Crystallography. 70, 2, p. 279-289 11 p.

    Research output: Contribution to journalArticle

  87. The cyclic AMP phosphodiesterase RegA critically regulates encystation in social and pathogenic amoebas

    Du, Q., Schilde, C., Birgersson, E., Chen, Z-H., McElroy, S. & Schaap, P. Feb 2014 In : Cellular Signalling. 26, 2, p. 453-459 7 p.

    Research output: Contribution to journalArticle

  88. Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei

    Mony, B. M., MacGregor, P., Ivens, A., Rojas, F., Cowton, A., Young, J., Horn, D. & Matthews, K. 30 Jan 2014 In : Nature. 505, 7485, p. 681-685 5 p.

    Research output: Contribution to journalLetter

  89. In Vitro and In Vivo studies of trypanocidal activity of dietary isothiocyanates

    Steverding, D., Michaels, S. & Read, K. D. 22 Jan 2014 In : Planta Medica.

    Research output: Contribution to journalLetter

  90. Is NMR fragment screening fine-tuned to assess druggability of protein-protein interactions?

    Dias, D. M., Van Molle, I., Baud, M. G. J., Galdeano, C., Geraldes, C. F. G. C. & Ciulli, A. 9 Jan 2014 In : ACS Medicinal Chemistry Letters. 5, 1, p. 23-28 6 p.

    Research output: Contribution to journalLetter

  91. Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment

    O'Rourke, P. E. F., Kalinowska-Tłuścik, J., Fyfe, P. K., Dawson, A. & Hunter, W. N. Jan 2014 In : BMC Structural Biology. 14, 12 p., 1

    Research output: Contribution to journalArticle

  92. Crystals on the cover 2014

    Einspahr, H., Weiss, M. S. & Hunter, W. N. Jan 2014 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 70, 1, p. 1 1 p.

    Research output: Contribution to journalEditorial

  93. ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome

    Tinti, M., Madeira, F., Murugesan, G., Hoxhaj, G., Toth, R. & Mackintosh, C. 2014 In : Database: the Journal of Biological Databases and Curation. 2014, 15 p., bat085

    Research output: Contribution to journalArticle

  94. Antiparasitic chemotherapy: from genomes to mechanisms

    Horn, D. & Duraisingh, M. T. 2014 In : Annual Review of Pharmacology and Toxicology. 54, p. 71-94 24 p.

    Research output: Contribution to journalArticle

  95. Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors

    Casale, E., Amboldi, N., Brasca, . M. G., Caronni, D., Colombo, N., Dalvit, C., Felder, E. R., Fogliatto, G., Galvani, A., Isacchi, A., Polucci, P., Riceputi, L., Sola, F., Visco, C., Zuccotto, F. & Casuscelli, F. 2014 In : Bioorganic & Medicinal Chemistry. 22, 15, p. 4135-4150 16 p.

    Research output: Contribution to journalArticle

  96. High-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC proteomics

    Güther, M. L. S., Urbaniak, M., Tavendale, A., Prescott, A. & Ferguson, M. A. J. 2014 In : Journal of Proteome Research. 13, 6, p. 2796-2806 11 p.

    Research output: Contribution to journalArticle

  97. Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers

    Tinti, M., Dissanayake, K., Synowsky, S., Albergante, L. & Mackintosh, C. 2014 In : Open Biology. 4, May, 16 p., 140029

    Research output: Contribution to journalArticle

  98. Identification of small molecule inhibitors of pre-mRNA splicing

    Pawellek, A., McElroy, S., Samatov, T., Mitchell, L., Woodland, A., Ryder, U., Gray, D., Lührmann, R. & Lamond, A. I. 2014 In : Journal of Biological Chemistry. 29 p.

    Research output: Contribution to journalArticle

  99. Improved annotation of 3' untranslated regions and complex loci by combination of strand-specific direct RNA sequencing, RNA-seq and ESTs

    Schurch, N. J., Cole, C., Sherstnev, A., Song, J., Duc, C., Storey, K. G., McLean, W. H. I., Brown, S. J., Simpson, G. G. & Barton, G. J. 2014 In : PLoS ONE. 9, 4, e94270

    Research output: Contribution to journalArticle

  100. Mechanism of Action of Compound-13: an α1-Selective Small Molecule Activator of AMPK

    Hunter, R. W., Foretz, M., Bultot, L., Fullerton, M. D., Deak, M., Ross, F. A., Hawley, S. A., Shpiro, N., Viollet, B., Barron, D., Kemp, B. E., Steinberg, G. R., Hardie, D. G. & Sakamoto, K. 2014 In : Chemistry & Biology. 21, 7, p. 866-879 14 p.

    Research output: Contribution to journalArticle

  101. Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects

    Patterson, S. & Wyllie, S. 2014 In : Trends in Parasitology. 30, 6, p. 289-298 10 p.

    Research output: Contribution to journalArticle

  102. Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells

    Lopez Pelaez, M., Lamont, D. J., Peggie, M., Shpiro, N., Gray, N. S. & Cohen, P. 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 6 p.

    Research output: Contribution to journalArticle

  103. Proteomic Selection of Immunodiagnostic Antigens for Trypanosoma congolense

    Fleming, J. R., Sastry, L., Crozier, T. W. M., Napier, G. B., Sullivan, L. & Ferguson, M. A. J. 2014 In : PLoS Neglected Tropical Diseases. 8, 6, e2936

    Research output: Contribution to journalArticle

  104. Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling

    Atrih, A., Mudaliar, M. A. V., Zakikhani, P., Lamont, D. J., Huang, J. T-J., Bray, S. E., Barton, G., Fleming, S. & Nabi, G. 2014 In : British Journal of Cancer. 110, 6, p. 1622-1633 12 p.

    Research output: Contribution to journalArticle

  105. Standardizing biochemistry dataset for medical research

    Bonney, W., Doney, A. & Jefferson, E. 2014 HEALTHINF 2014 - 7th International Conference on Health Informatics, Proceedings; Part of 7th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2014. p. 205-210 6 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  106. Structure-based virtual screening for the identification of RNA-binding ligands

    Daldrop, P. & Brenk, R. 2014 Therapeutic applications of ribozymes and riboswitches: methods and protocols. Lafontaine, D. & Dubé, A. (eds.). Humana Press, p. 127-139 13 p. (Methods in Molecular Biology; vol. 1103)

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  107. The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution

    Bowman, A., Hammond, C. M., Stirling, A., Ward, R., Shang, W., El-Mkami, H., Robinson, D. A., Svergun, D. I., Norman, D. G. & Owen-Hughes, T. 2014 In : Nucleic Acids Research. 42, 9, p. 6038-6051 13 p.

    Research output: Contribution to journalArticle

  108. The role of ligand efficiency metrics in drug discovery

    Hopkins, A. L., Keserü, G. M., Leeson, P. D., Rees, D. C. & Reynolds, C. H. 2014 In : Nature Reviews Drug Discovery. 13, 2, p. 105-121 17 p.

    Research output: Contribution to journalArticle

  109. Touching from a distance: evolution of interplay between the nuclear pore complex, nuclear basket, and the mitotic spindle

    Holden, J. M., Koreny, L., Kelly, S., Chait, B. T., Rout, M. P., Field, M. C. & Obado, S. O. 2014 In : Nucleus. 5, 4, p. 304-310 7 p.

    Research output: Contribution to journalArticle

  110. Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control

    Glover, L., Hutchinson, S., Alsford, S., McCulloch, R., Field, M. C. & Horn, D. Dec 2013 In : Cellular Microbiology. 15, 12, p. 1984-1993 10 p.

    Research output: Contribution to journalArticle

  111. Fragment-based hit identification: thinking in 3D

    Morley, A. D., Pugliese, A., Birchall, K., Bower, J., Brennan, P., Brown, N., Chapman, T., Drysdale, M., Gilbert, I. H., Hoelder, S., Jordan, A., Ley, S. V., Merritt, A., Miller, D., Swarbrick, M. E. & Wyatt, P. G. Dec 2013 In : Drug Discovery Today. 18, 23-24, p. 1221-1227 7 p.

    Research output: Contribution to journalArticle

  112. Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens

    Srikannathasan, V., English, G., Bui, N. K., Trunk, K., O'Rourke, P. E. F., Rao, V. A., Vollmer, W., Coulthurst, S. J. & Hunter, W. N. Dec 2013 In : Acta Crystallographica Section D: Biological Crystallography. 69, 12, p. 2468-2482 15 p.

    Research output: Contribution to journalArticle

  113. Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain

    Ferguson, F. M., Fedorov, O., Chaikuad, A., Philpott, M., Muniz, J. R. C., Felletar, I., von Delft, F., Heightman, T., Knapp, S., Abell, C. & Ciulli, A. Dec 2013 In : Journal of Medicinal Chemistry. 56, 24, p. 10183-10187 5 p.

    Research output: Contribution to journalArticle

  114. Two high-resolution structures of the human E3 ubiquitin ligase Siah1

    Rimsa, V., Eadsforth, T. C. & Hunter, W. N. Dec 2013 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 12, p. 1339-1343 5 p.

    Research output: Contribution to journalArticle

  115. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

    Brown, S. J. & 33 others Saunders, S. P., Goh, C. S. M., Palmer, C. N. A., Porter, R. M., Cole, C., Campbell, L. E., Gierlinski, M., Barton, G. J., Schneider, G., Balmain, A., Prescott, A. R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y-A., Tavendale, R., Mukhopadhyay, S., Turner, S. W., Madhok, V. B., Sullivan, F. M., Relton, C., Burn, J., Meggitt, S., Smith, C. H., Allen, M. A., Barker, J. N. W. N., Reynolds, N. J., Cordell, H. J., Irvine, A. D., McLean, W. H. I., Sandilands, A. & Fallon, P. G. Nov 2013 In : Journal of Allergy and Clinical Immunology. 132, 5, p. 1121-1129 9 p.

    Research output: Contribution to journalArticle

  116. Construction of reference chromosome-scale pseudomolecules for potato: integrating the potato genome with genetic and physical maps

    Sharma, S. K. , Bolser, D. , de Boer, J. , Sønderkær, M. , Amoros, W. , Carboni, M. F. , D'Ambrosio, J. M. , de la Cruz, G. , Di Genova, A. , Douches, D. S. , Eguiluz, M. , Guo, X. , Guzman, F. , Hackett, C. A. , Hamilton, J. P. , Li, G. , Li, Y. , Lozano, R. , Maass, A. , Marshall, D. & 25 others Martinez, D., McLean, K., Mejía, N., Milne, L., Munive, S., Nagy, I., Ponce, O., Ramirez, M., Simon, R., Thomson, S. J., Torres, Y., Waugh, R., Zhang, Z., Huang, S., Visser, R. G. F., Bachem, C. W. B., Sagredo, B., Feingold, S. E., Orjeda, G., Veilleux, R. E., Bonierbale, M., Jacobs, J. M. E., Milbourne, D., Martin, D. M. A. & Bryan, G. J. Nov 2013 In : G3 : Genes, Genomes, Genetics. 3, 11, p. 2031-2047 17 p.

    Research output: Contribution to journalArticle

  117. Transcription Termination and Chimeric RNA Formation Controlled by Arabidopsis thaliana FPA

    Duc, C., Sherstnev, A., Cole, C., Barton, G. & Simpson, G. G. 31 Oct 2013 In : PLoS Genetics. 9, 10, e1003867

    Research output: Contribution to journalArticle

  118. Anti-malarial agents

    Gilbert, I., Norcross, N., Baragana, B. & Porzelle, A. 17 Oct 2013 PCT/GB2013/050633

    Research output: Patent

  119. The RNA-binding protein FPA regulates flg22-triggered defense responses and transcription factor activity by alternative polyadenylation

    Lyons, R., Iwase, A., Gänsewig, T., Sherstnev, A., Duc, C., Barton, G. J., Hanada, K., Higuchi-Takeuchi, M., Matsui, M., Sugimoto, K., Kazan, K., Simpson, G. G. & Shirasu, K. 9 Oct 2013 In : Scientific Reports. 3, 10 p., 2866

    Research output: Contribution to journalArticle

  120. Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain

    Rao, F. V., Schüttelkopf, A. W., Dorfmueller, H. C., Ferenbach, A. T., Navratilova, I. & van Aalten, D. M. F. 2 Oct 2013 In : Open Biology. 3, 130021

    Research output: Contribution to journalArticle

  121. Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy

    Ong, H. B., Sienkiewicz, N., Wyllie, S., Patterson, S. & Fairlamb, A. H. Oct 2013 In : Molecular Microbiology. 90, 2, p. 443-455 13 p.

    Research output: Contribution to journalArticle

  122. Drug discovery for the treatment of leishmaniasis, African sleeping sickness and Chagas disease

    Avery, V., Buckner, F., Baell, J., Fairlamb, A., Michels, P. A. & Tarleton, R. Oct 2013 In : Future Medicinal Chemistry. 5, 15, p. 1709-1718 10 p.

    Research output: Contribution to journalArticle

  123. The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

    Patterson, S., Wyllie, S., Stojanovski, L., Perry, M. R., Simeons, F. R. C., Norval, S., Osuna-Cabello, M., De Rycker, M., Read, K. D. & Fairlamb, A. H. Oct 2013 In : Antimicrobial Agents and Chemotherapy. 57, 10, p. 4699-4706 8 p.

    Research output: Contribution to journalArticle

  124. A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei

    Urbaniak, M. D., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Navratilova, I. H., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J. 20 Sep 2013 In : ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.

    Research output: Contribution to journalArticle

  125. Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase

    Hampton, S. E., Schipani, A., Bosch-Navarrete, C., Recio, E., Kaiser, M., Kahnberg, P., González-Pacanowska, D., Johansson, N. G. & Gilbert, I. H. 15 Sep 2013 In : Bioorganic & Medicinal Chemistry. 21, 18, p. 5876-5885 10 p.

    Research output: Contribution to journalArticle

  126. Yeast Mnn9 is both a priming glycosyltransferase and an allosteric activator of mannan biosynthesis

    Striebeck, A., Robinson, D. A., Schüttelkopf, A. W. & van Aalten, D. M. F. Sep 2013 In : Open Biology. 3, 9, 130022

    Research output: Contribution to journalArticle

  127. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery

    Silvestre, H. L., Blundell, T. L., Abell, C. & Ciulli, A. 6 Aug 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 32, p. 12984-12989 6 p.

    Research output: Contribution to journalArticle

  128. Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target

    Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Urbaniak, M. D., Ibrahim, A. F. M., Ferguson, M. A. J., Jin, C. & van Aalten, D. M. F. Aug 2013 In : Molecular Microbiology. 89, 3, p. 479-493 15 p.

    Research output: Contribution to journalArticle

  129. Multimeric complexes among Ankyrin-Repeat and SOCS-box Protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 Ubiquitin Ligases

    Thomas, J. C., Matak-Vinkovic, D., Van Molle, I. & Ciulli, A. 25 Jul 2013 In : Biochemistry. 52, 31, p. 5236-5246 11 p.

    Research output: Contribution to journalArticle

  130. Structure of the SCAN domain of human paternally expressed gene 3 protein

    Rimsa, V., Eadsforth, T. C. & Hunter, W. N. 23 Jul 2013 In : PLoS ONE. 8, 7, e69538

    Research output: Contribution to journalArticle

  131. Genetic and structural validation of Aspergillus fumigatus N-acetylphosphoglucosamine mutase as an antifungal target

    Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Mariño, K., Ibrahim, A. F. M., Albarbarawi, O., Ferguson, M. A. J., Jin, C. & Van Aalten, D. M. F. 11 Jul 2013 In : Bioscience Reports. 33, 5, 11 p., e00063

    Research output: Contribution to journalArticle

  132. Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.

    De Rycker, M., Hallyburton, I., Thomas, J., Campbell, L., Wyllie, S., Joshi, D., Cameron, S., Gilbert, I. H., Wyatt, P. G., Frearson, J. A., Fairlamb, A. H. & Gray, D. W. Jul 2013 In : Antimicrobial Agents and Chemotherapy. 57, 7, p. 2913-2922 10 p.

    Research output: Contribution to journalArticle

  133. From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules

    Woodland, A., Grimaldi, R., Luksch, T., Cleghorn, L. A. T., Ojo, K. K., Van Voorhis, W. C., Brenk, R., Frearson, J. A., Gilbert, I. H. & Wyatt, P. G. Jul 2013 In : ChemMedChem. 8, 7, p. 1127-1137 11 p.

    Research output: Contribution to journalArticle

  134. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins

    Gabernet-Castello, C., O'Reilly, A. J., Dacks, J. B. & Field, M. C. 15 May 2013 In : Molecular Biology of the Cell. 24, 10, p. 1574-1583 10 p.

    Research output: Contribution to journalArticle

  135. A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle

    Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., Shattock, M. J., Calaghan, S. C. & Fuller, W. 10 May 2013 In : Journal of Biological Chemistry. 288, 19, p. 13808-13820 13 p.

    Research output: Contribution to journalArticle

  136. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

    Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P. 1 May 2013 In : Biochemical Journal. 451, 3, p. 427-437 11 p.

    Research output: Contribution to journalArticle

  137. De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments

    Urich, R., Wishart, G., Kiczun, M., Richters, A., Tidten-Luksch, N., Rauh, D., Sherborne, B., Wyatt, P. G. & Brenk, R. May 2013 In : ACS Chemical Biology. 8, 5, p. 1044-1052 9 p.

    Research output: Contribution to journalArticle

  138. Evolution of modular intraflagellar transport from a coatomer-like progenitor

    van Dam, T. J. P., Townsend, M. J., Turk, M., Schlessinger, A., Sali, A., Field, M. C. & Huynen, M. A. 23 Apr 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 17, p. 6943-6948 6 p.

    Research output: Contribution to journalArticle

  139. Structure of a complex phosphoglycan epitope from gp72 of Trypanosoma cruzi

    Allen, S., Richardson, J. M., Mehlert, A. & Ferguson, M. A. J. 19 Apr 2013 In : Journal of Biological Chemistry. 288, 16, p. 11093-11105 13 p.

    Research output: Contribution to journalArticle

  140. Improved sperm function / activity

    Barratt, C. & Wyatt, P. 18 Apr 2013 WO2013054111 A1

    Research output: Patent

  141. Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria

    Gargiulo, L., Papaioannou, M., Sica, M., Talini, G., Chaidos, A., Richichi, B., Nikolaev, A. V., Nativi, C., Layton, M., de la Fuente, J., Roberts, I., Luzzatto, L., Notaro, R. & Karadimitris, A. 4 Apr 2013 In : Blood. 121, 14, p. 2753-2761 9 p.

    Research output: Contribution to journalArticle

  142. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

    Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3 Apr 2013 In : EMBO Journal. 32, 7, p. 1008-22 15 p.

    Research output: Contribution to journalArticle

  143. The architecture of EssB, an integral membrane component of the type VII secretion system

    Zoltner, M., Norman, D. G., Fyfe, P. K., El Mkami, H., Palmer, T. & Hunter, W. N. 2 Apr 2013 In : Structure. 21, 4, p. 595-603 9 p.

    Research output: Contribution to journalArticle

  144. Proteomic analysis of clathrin interactions in trypanosomes reveals dynamic evolution of endocytosis

    Adung'a, V. O., Gadelha, C. & Field, M. C. Apr 2013 In : Traffic. 14, 4, p. 440-457 18 p.

    Research output: Contribution to journalScientific review

  145. DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes

    Glover, L., Alsford, S. & Horn, D. Mar 2013 In : PLoS Pathogens. 9, 3, 15 p., ARTN e1003260

    Research output: Contribution to journalArticle

  146. Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story

    Baker, N., de Koning, H. P., Maeser, P. & Horn, D. Mar 2013 In : Trends in Parasitology. 29, 3, p. 110-118 9 p.

    Research output: Contribution to journalScientific review

  147. The functional exchangeability of pk- and k-turns in RNA structure

    Daldrop, P., Masquida, B. & Lilley, D. M. J. Mar 2013 In : RNA Biology. 10, 3, p. 445-452 8 p.

    Research output: Contribution to journalArticle

  148. The importance of the N-terminus of T7 endonuclease I in the interaction with DNA junctions

    Freeman, A. D. J., Déclais, A-C. & Lilley, D. M. J. 23 Jan 2013 In : Journal of Molecular Biology. 425, 2, p. 395-410 16 p.

    Research output: Contribution to journalArticle

  149. Characterization of Staphylococcus aureus EssB, an integral membrane component of the Type VII secretion system: atomic resolution crystal structure of the cytoplasmic segment

    Zoltner, M., Fyfe, P. K., Palmer, T. & Hunter, W. N. 15 Jan 2013 In : Biochemical Journal. 449, 2, p. 469-477 9 p.

    Research output: Contribution to journalArticle

  150. PGE2 induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway

    Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15 Jan 2013 In : Journal of Immunology. 190, 2, p. 565-577 13 p.

    Research output: Contribution to journalArticle

  151. Structural plasticity of histones H3–H4 facilitates their allosteric exchange between RbAp48 and ASF1

    Zhang, W., Yyl, M., Ward, R., Sobott, F., Maman, J., Murthy, A., Watson, A., Fedorov, O., Bowman, A., Owen-Hughes, T., El Mkami, H., Murzina, N., Norman, D. G. & Laue, E. Jan 2013 In : Nature Structural & Molecular Biology. 20, 1, p. 29-35 7 p.

    Research output: Contribution to journalArticle

  152. Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

    Munday, J. C., Eze, A. A., Baker, N., Glover, L., Clucas, C., Andrés, D. A., Natto, M. J., Teka, I. A., McDonald, J., Lee, R. S., Graf, F. E., Ludin, P., Burchmore, R. J. S., Turner, C. M. R., Tait, A., MacLeod, A., Mäser, P., Barrett, M. P., Horn, D. & De Koning, H. P. 2013 In : Journal of Antimicrobial Chemotherapy.

    Research output: Contribution to journalArticle

  153. A Lack of premature termination codon read-through efficacy of PTC124 (Ataluren) in a diverse array of reporter assays

    McElroy, S. P., Nomura, T., Torrie, L. S., Warbrick, E., Gartner, U., Wood, G. & McLean, W. H. I. 2013 In : PLoS Biology. 11, 6, e1001593

    Research output: Contribution to journalArticle

  154. A mechanistic comparison of the varkud satellite and hairpin ribozymes

    Wilson, T. J. & Lilley, D. M. J. 2013 Catalytic RNA. Soukup, G. A. (ed.). London: Academic Press, p. 93-121 29 p. (Progress in molecular biology and translational science; vol. 120)

    Research output: Chapter in Book/Report/Conference proceedingChapter

  155. A nonsense mutation in the mattrin gene causes the matted mouse phenotype and is a predisposing gene for atopic dermatitis in humans

    Goh, C. S., Saunders, S. P., Cole, C., Weidinger, S., Baurecht, H., Lee, Y., Reynolds, N. J., Barker, J. N., Cordell, H. J., Brown, S. J., Irvine, A. D., McLean, I., Sandilands, A. & Fallon, P. G. 2013 In : Journal of Investigative Dermatology. 133, S1, p. S145 1 p., 854

    Research output: Contribution to journalMeeting abstract

  156. A sweet TET-a-tete-synergy of TET proteins and O-GlcNAc transferase in transcription

    Mariappa, D., Pathak, S. & van Aalten, D. M. F. 2013 In : EMBO Journal. 32, 5, p. 612-613 2 p.

    Research output: Contribution to journalEditorial

  157. Biophysical screening for the discovery of small-molecule ligands

    Ciulli, A. 2013 Protein-ligand interactions: methods and applications. Williams, M. A. & Daviter, T. (eds.). Humana Press, p. 357-388 32 p. (Methods in Molecular Biology; vol. 1008)

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  158. Creation and characterization of glycosyltransferase mutants of trypanosoma brucei

    Izquierdo, L., Güther, M. L. S. & Ferguson, M. A. J. 2013 Glycosyltransferases. Brockhausen, I. (ed.). Humana Press, p. 249-275 27 p. (Methods in Molecular Biology; vol. 1022)

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  159. Discovery and structure-activity relationships of pyrrolone antimalarials

    Murugesan, D., Mital, A., Kaiser, M., Shackleford, D. M., Morizzi, J., Katneni, K., Campbell, M., Hudson, A., Charman, S. A., Yeates, C. & Gilbert, I. H. 2013 In : Journal of Medicinal Chemistry. 56, 7, p. 2975-2990 16 p.

    Research output: Contribution to journalArticle

  160. Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa

    Cukier, C. D., Hope, A. G., Elamin, A. A., Moynie, L., Schnell, R., Schach, S., Kneuper, H., Singh, M., Naismith, J. H., Lindqvist, Y., Gray, D. W. & Schneider, G. 2013 In : ACS Chemical Biology. n/a, cb4005063

    Research output: Contribution to journalArticle

  161. Discovery of Β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

    Aristotelous, T., Ahn, S., Shukla, A. K., Gawron, S., Sassano, M. F., Kahsai, A. W., Wingler, L. M., Zhu, X., Tripathi-Shukla, P., Huang, X-P., Riley, J., Besnard, J., Read, K. D., Roth, B. L., Gilbert, I. H., Hopkins, A. L., Lefkowitz, R. J. & Navratilova, I. 2013 In : ACS Medicinal Chemistry Letters. 4, 10, p. 1005-1010 6 p.

    Research output: Contribution to journalArticle

  162. Drug discovery for neglected diseases: molecular target-based and phenotypic approaches

    Gilbert, I. H. 2013 In : Journal of Medicinal Chemistry. 56, 20, p. 7719-7726 8 p.

    Research output: Contribution to journalArticle

  163. Electromechanical Behaviour of Nafion-based Soft Actuators

    Naji, L., Chudek, J. A., Abel, E. W. & Baker, R. T. 2013 In : Journal of Physical Chemistry B. 1, 19, p. 2502-2514 13 p.

    Research output: Contribution to journalArticle

  164. Imaging African trypanosomes

    MacLean, L., Myburgh, E., Rodgers, J. & Price, H. P. 2013 In : Parasite Immunology. 35, 9-10, p. 283-294 12 p.

    Research output: Contribution to journalArticle

  165. Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes

    Narlikar, G. J., Sundaramoorthy, R. & Owen-Hughes, T. 2013 In : Cell. 154, 3, p. 490-503 14 p.

    Research output: Contribution to journalArticle

  166. Mechanistic dichotomy in the asymmetric allylation of aldehydes with allyltrichlorosilanes catalyzed by chiral pyridine N-oxides

    Malkov, A. V., Stončius, S., Bell, M., Castelluzzo, F., Ramírez-López, P., Biedermannová, L., Langer, V., Rulíšek, L. & Kočovský, P. 2013 In : Chemistry: a European Journal. 19, 28, p. 9167-9185 19 p.

    Research output: Contribution to journalArticle

  167. Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry

    Hahne, H., Sobotzki, N., Nyberg, T., Helm, D., Borodkin, V. S., van Aalten, D. M. F., Agnew, B. & Kuster, B. 2013 In : Journal of Proteome Research. 12, 2, p. 927-936 10 p.

    Research output: Contribution to journalArticle

  168. Regulation of the cardiac Na(+) pump by palmitoylation of its catalytic and regulatory subunits

    Howie, J., Tulloch, L. B., Shattock, M. J. & Fuller, W. 2013 In : Biochemical Society Transactions. 41, 1, p. 95-100 6 p.

    Research output: Contribution to journalArticle

  169. Structure of Pseudomonas aeruginosa inosine 5-monophosphate dehydrogenase

    Rao, V. A., Shepherd, S. M., Owen, R. & Hunter, W. N. 2013 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 3, p. 243-247 5 p.

    Research output: Contribution to journalArticle

  170. Structure-Activity Relationship Studies of Pyrrolone Antimalarial Agents

    Murugesan, D., Kaiser, M., White, K. L., Norval, S., Riley, J., Wyatt, P. G., Charman, S. A., Read, K. D., Yeates, C. & Gilbert, I. H. 2013 In : ChemMedChem.

    Research output: Contribution to journalArticle

  171. The architecture of Trypanosoma brucei tubulin-binding cofactor B and implications for function

    Fleming, J. R., Morgan, R. E., Fyfe, P. K., Kelly, S. M. & Hunter, W. N. 2013 In : FEBS Journal. 280, 14, p. 3270-3280 11 p.

    Research output: Contribution to journalArticle

  172. The CD11b-integrin (ITGAM) and systemic lupus erythematosus

    Fagerholm, S. C., Macpherson, M., James, M. J., Sevier-Guy, C. & Lau, C. S. 2013 In : Lupus. 22, 7, p. 657-663 7 p.

    Research output: Contribution to journalArticle

  173. The impact of KLF2 modulation on the transcriptional program and function of CD8 T Cells

    Preston, G. C., Feijoo-Carnero, C., Schurch, N., Cowling, V. H. & Cantrell, D. A. 2013 In : PLoS ONE. 8, 10, 16 p., e77537

    Research output: Contribution to journalArticle

  174. The plasticity of a structural motif in RNA: Structural polymorphism of a kink turn as a function of its environment

    Daldrop, P. & Lilley, D. M. J. 2013 In : RNA: a Publication of the RNA Society. 19, 3, p. 357-364 8 p.

    Research output: Contribution to journalArticle

  175. Automated design of ligands to polypharmacological profiles

    Gilbert, I. H. & 20 others Besnard, J., Ruda, G. F., Setola, V., Abecassis, K., Rodriguiz, R. M., Huang, X-P., Norval, S., Sassano, M. F., Shin, A. I., Webster, L. A., Simeons, F. R. C., Stojanovski, L., Prat, A., Seidah, N. G., Constam, D. B., Bickerton, G. R., Read, K. D., Wetsel, W. C., Roth, B. L. & Hopkins, A. L. 13 Dec 2012 In : Nature. 492, 7428, p. 215-+ 8 p.

    Research output: Contribution to journalArticle

  176. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P-3-dependent mechanisms leading to resistance to PDK1 inhibitors

    Najafov, A., Shpiro, N. & Alessi, D. R. Dec 2012 In : Biochemical Journal. 448, 2, p. 285-295 11 p.

    Research output: Contribution to journalArticle

  177. A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes

    De Rycker, M., O'Neill, S., Joshi, D., Campbell, L., Gray, D. W. & Fairlamb, A. H. 29 Nov 2012 In : PLoS Neglected Tropical Diseases. 6, 11, p. e1932

    Research output: Contribution to journalArticle

  178. Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α

    Buckley, D. L., Gustafson, J. L., Van-Molle, I., Roth, A. G., Tae, H. S., Gareiss, P. C., Jorgensen, W. L., Ciulli, A. & Crews, C. M. 12 Nov 2012 In : Angewandte Chemie International Edition. 51, 46, p. 11463-11467 5 p.

    Research output: Contribution to journalArticle

  179. Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei

    Alsford, S. & Horn, D. Nov 2012 In : Nucleic Acids Research. 40, 20, p. 10150-10160 11 p.

    Research output: Contribution to journalArticle

  180. Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma

    Brown, S. J. & 31 others Pohler, E., Mamai, O., Hirst, J., Zamiri, M., Horn, H., Nomura, T., Irvine, A. D., Moran, B., Wilson, N. J., Smith, F. J. D., Goh, C. S. M., Sandilands, A., Cole, C., Barton, G. J., Evans, A. T., Shimizu, H., Akiyama, M., Suehiro, M., Konohana, I., Shboul, M., Teissier, S., Boussofara, L., Denguezli, M., Saad, A., Gribaa, M., Dopping-Hepenstal, P. J., McGrath, J. A., Goudie, D. R., Reversade, B., Munro, C. S. & McLean, W. H. I. Nov 2012 In : Nature Genetics. 44, 11, p. 1272-1276 5 p.

    Research output: Contribution to journalArticle

  181. New secreted toxins and immunity proteins encoded within the type VI secretion system gene cluster of Serratia marcescens

    English, G., Trunk, K., Rao, V. A., Srikannathasan, V., Hunter, W. N. & Coulthurst, S. J. Nov 2012 In : Molecular Microbiology. 86, 4, p. 921-936 16 p.

    Research output: Contribution to journalArticle

  182. Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems

    Nelson, S. A., Li, Z., Newton, I. P., Fraser, D., Milne, R. E., Martin, D. M. A., Schiffmann, D., Yang, X., Dormann, D., Weijer, C. J., Appleton, P. L. & Nathke, I. S. Nov 2012 In : Disease Models & Mechanisms. 5, 6, p. 940-947 8 p.

    Research output: Contribution to journalArticle

  183. Dissecting fragment-based lead discovery at the von hippel-lindau protein: Hypoxia inducible factor 1α protein-protein interface

    Van Molle, I., Thomann, A., Buckley, D. L., So, E. C., Lang, S., Crews, C. M. & Ciulli, A. 26 Oct 2012 In : Chemistry & Biology. 19, 10, p. 1300-1312 13 p.

    Research output: Contribution to journalArticle

  184. Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

    Jones, D. C., Alphey, M. S., Wyllie, S. & Fairlamb, A. H. Oct 2012 In : Molecular Microbiology. 86, 1, p. 51-64 14 p.

    Research output: Contribution to journalArticle

  185. Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121

    Hudson, S. A., McLean, K. J., Surade, S., Yang, Y-Q., Leys, D., Ciulli, A., Munro, A. W. & Abell, C. 10 Sep 2012 In : Angewandte Chemie International Edition. 51, 37, p. 9311-9316 6 p.

    Research output: Contribution to journalArticle

  186. Direct sequencing of Arabidopsis thaliana RNA reveals patterns of cleavage and polyadenylation

    Sherstnev, A., Duc, C., Cole, C., Zacharaki, V., Hornyik, C., Ozsolak, F., Milos, P. M., Barton, G. J. & Simpson, G. G. Aug 2012 In : Nature Structural & Molecular Biology. 19, 8, p. 845-852 8 p.

    Research output: Contribution to journalArticle

  187. Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases

    Paveley, R. A., Mansour, N. R., Hallyburton, I., Bleicher, L. S., Benn, A. E., Mikic, I., Guidi, A., Gilbert, I. H., Hopkins, A. L. & Bickle, Q. D. 31 Jul 2012 In : PLoS Neglected Tropical Diseases. 6, 7, 11 p., e1762

    Research output: Contribution to journalArticle

  188. Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

    Baker, N., Glover, L., Munday, J. C., Andres, D. A., Barrett, M. P., de Koning, H. P. & Horn, D. 3 Jul 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 27, p. 10996-11001 6 p.

    Research output: Contribution to journalArticle

  189. Essential Role for IKK beta in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

    Pauls, E., Shpiro, N., Peggie, M., Young, E. R., Sorcek, R. J., Tan, L., Choi, H. G. & Cohen, P. 1 Jun 2012 In : Journal of Biological Chemistry. 287, 23, p. 19216-19228 13 p.

    Research output: Contribution to journalArticle

  190. Pathways analysis in kidney cancer using proteomics approach

    Zakikhani, M., Atrih, A., Lamont, S. R., Goodman, C., Fleming, I. N. & Nabi, G. Jun 2012 In : BJU International. 109, p. 24-24 1 p.

    Research output: Contribution to journalSpecial issue

  191. Structure and folding of a rare, natural kink turn in RNA with an A•A pair at the 2•d2n position

    Schroeder, K. T., Daldrop, P., McPhee, S. A. & Lilley, D. M. J. Jun 2012 In : RNA: a Publication of the RNA Society. 18, 6, p. 1257-1266 10 p.

    Research output: Contribution to journalArticle

  192. Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes

    Alsford, S., duBois, K., Horn, D. & Field, M. C. 29 May 2012 In : Expert reviews in molecular medicine. 14, 20 p., ARTN e13

    Research output: Contribution to journalScientific review

  193. Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation

    Klotz-Noack, K., McIntosh, D., Schurch, N., Pratt, N. & Blow, J. J. 15 May 2012 In : Journal of Cell Science. 125, 10, p. 2436-2445 10 p.

    Research output: Contribution to journalArticle

  194. Combining PET biodistribution and equilibrium dialysis assays to assess the free brain concentration and BBB transport of CNS drugs

    Gunn, R. N., Summerfield, S. G., Salinas, C. A., Read, K. D., Guo, Q., Searle, G. E., Parker, C. A., Jeffrey, P. & Laruelle, M. May 2012 In : Journal of Cerebral Blood Flow and Metabolism. 32, 5, p. 874-883 10 p.

    Research output: Contribution to journalArticle

  195. Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo

    Hack, K., Reilly, L., Palmer, C., Read, K., Norval, S., Kime, R., Booth, K. & Foerster, J. May 2012 In : PLoS ONE. 7, 5

    Research output: Contribution to journalArticle

  196. The lipid-linked oligosaccharide donor specificities of Trypanosoma brucei oligosaccharyltransferases

    Izquierdo, L., Mehlert, A. & Ferguson, M. A. J. May 2012 In : Glycobiology. 22, 5, p. 696-703 8 p.

    Research output: Contribution to journalArticle

  197. Trypanosomal histone γH2A and the DNA damage response

    Glover, L. & Horn, D. May 2012 In : Molecular and Biochemical Parasitology. 183, 1, p. 78-83 6 p.

    Research output: Contribution to journalArticle

  198. Human box C/D snoRNA processing conservation across multiple cell types

    Scott, M. S., Ono, M., Yamada, K., Endo, A., Barton, G. J. & Lamond, A. I. Apr 2012 In : Nucleic Acids Research. 40, 8, p. 3676-3688 13 p.

    Research output: Contribution to journalArticle

  199. Modeling of the N-Glycosylated Transferrin Receptor Suggests How Transferrin Binding Can Occur within the Surface Coat of Trypanosoma brucei

    Mehlert, A., Wormald, M. R. & Ferguson, M. A. J. Apr 2012 In : PLoS Pathogens. 8, 4, p. - 11 p., e1002618

    Research output: Contribution to journalArticle

  200. Regulation of the cardiac sodium pump

    Fuller, W., Tulloch, L. B., Howie, J., Wypijewski, K. J., Shattock, M. J. & Calaghan, S. C. Apr 2012 In : Cellular and Molecular Life Sciences. 70, 8, p. 1357-1380 24 p.

    Research output: Contribution to journalArticle

  201. The de novo and salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-form Trypanosoma brucei

    Kuettel, S., Wadum, M. C. T., Guther, M. L. S., Marino, K., Riemer, C. & Ferguson, M. A. J. Apr 2012 In : Molecular Microbiology. 84, 2, p. 340-351 12 p.

    Research output: Contribution to journalArticle

  202. Transcriptome analysis of skin reveals differences between atopic eczema cases stratified for filaggrin genotype

    Brown, S., Cole, C., Irvine, A., Barton, G. & McLean, I. Apr 2012 In : British Journal of Dermatology. 166, 4, p. e26-e27 2 p., O-30

    Research output: Contribution to journalArticle

  203. A quantitative spatial proteomics analysis of proteome turnover in human cells

    Boisvert, F-M., Ahmad, Y., Gierlinski, M., Charrière, F., Lamont, D., Scott, M., Barton, G. & Lamond, A. I. 1 Mar 2012 In : Molecular & Cellular Proteomics. 11, 3, M111.011429

    Research output: Contribution to journalArticle

  204. Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei

    Kelly, J. M., Taylor, M. C., Horn, D., Loza, E., Kalvinsh, I. & Bjorkling, F. 1 Mar 2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 5, p. 1886-1890 5 p.

    Research output: Contribution to journalArticle

  205. Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness

    Abdelwahab, N. Z., Crossman, A. T., Sullivan, L., Ferguson, M. A. J. & Urbaniak, M. D. Mar 2012 In : Chemical Biology & Drug Design. 79, 3, p. 270-278 9 p.

    Research output: Contribution to journalArticle

  206. Conserved signal peptide recognition systems across the prokaryotic domains

    Coulthurst, S. J., Dawson, A., Hunter, W. N. & Sargent, F. 28 Feb 2012 In : Biochemistry. 51, 8, p. 1678-1686 9 p.

    Research output: Contribution to journalArticle

  207. Synergy of peptide and sugar in O-GlcNAcase substrate recognition

    Schimpl, M., Borodkin, V. S., Gray, L. J. & van Aalten, D. M. F. 24 Feb 2012 In : Chemistry & Biology. 19, 2, p. 173-178 6 p.

    Research output: Contribution to journalArticle

  208. Comparative proteomics profiling of a gentamicin-attenuated Leishmania infantum cell line identifies key changes in parasite thiol-redox metabolism

    Daneshvar, H., Wyllie, S., Phillips, S., Hagan, P. & Burchmore, R. 16 Feb 2012 In : Journal of Proteomics. 75, 5, p. 1463-1471 9 p.

    Research output: Contribution to journalArticle

  209. Quinol derivatives as potential trypanocidal agents

    Capes, A., Patterson, S., Wyllie, S., Hallyburton, I., Collie, I. T., McCarroll, A. J., Stevens, M. F. G., Frearson, J. A., Wyatt, P. G., Fairlamb, A. H. & Gilbert, I. H. 15 Feb 2012 In : Bioorganic & Medicinal Chemistry. 20, 4, p. 1607-1615 9 p.

    Research output: Contribution to journalArticle

  210. High-throughput decoding of antitrypanosomal drug efficacy and resistance

    Alsford, S., Eckert, S., Baker, N., Glover, L., Sanchez-Flores, A., Leung, K. F., Turner, D. J., Field, M. C., Berriman, M. & Horn, D. 9 Feb 2012 In : Nature. 482, 7384, p. 232-236 6 p.

    Research output: Contribution to journalArticle

  211. Infectious disease: Genomics decodes drug action

    Fairlamb, A. H. 9 Feb 2012 In : Nature. 482, 7384, p. 167-169 3 p.

    Research output: Contribution to journalEditorial

  212. Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

    Hjerpe, R., Thomas, Y., Chen, J., Zemla, A., Curran, S., Shpiro, N., Dick, L. R. & Kurz, T. 1 Feb 2012 In : Biochemical Journal. 441, 3, p. 927-936 10 p.

    Research output: Contribution to journalArticle

  213. The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis

    Wyllie, S., Patterson, S., Stojanovski, L., Simeons, F. R. C., Norval, S., Kime, R., Read, K. D. & Fairlamb, A. H. 1 Feb 2012 In : Science Translational Medicine. 4, 119, p. - 7 p., 119re1

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  214. Biosensor-Based Approach to the Identification of Protein Kinase Ligands with Dual-Site Modes of Action

    Navratilova, I., Macdonald, G., Robinson, C., Hughes, S., Mathias, J., Phillips, C. & Cook, A. Feb 2012 In : Journal of Biomolecular Screening. 17, 2, p. 183-193 11 p.

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  215. Quantifying the chemical beauty of drugs

    Bickerton, G. R., Paolini, G. V., Besnard, J., Muresan, S. & Hopkins, A. L. Feb 2012 In : Nature Chemistry. 4, 2, p. 90-98 9 p.

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  216. The crystal structure of Leishmania major N-5,N-10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target

    Eadsforth, T. C., Cameron, S. & Hunter, W. N. Feb 2012 In : Molecular and Biochemical Parasitology. 181, 2, p. 178-185 8 p.

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  217. Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

    Brand, S., Cleghorn, L. A. T., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Read, K. D., Wyatt, P. G. & Gilbert, I. H. 12 Jan 2012 In : Journal of Medicinal Chemistry. 55, 1, p. 140-152 13 p.

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  218. Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

    Spinks, D., Torrie, L. S., Thompson, S., Harrison, J. R., Frearson, J. A., Read, K. D., Fairlamb, A. H., Wyatt, P. G. & Gilbert, I. H. 2 Jan 2012 In : ChemMedChem. 7, 1, p. 95-106 12 p.

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  219. A comparative study of the CYP450 inhibition potential of marketed drugs using two fluorescence based assay platforms routinely used in the pharmaceutical industry

    Kajbaf, M., Longhi, R., Montanari, D., Vinco, F., Rigo, M., Fontano, S. & Read, K. D. 2012 In : Drug Metabolism Letters. 5, 1, p. 30-39 10 p.

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  220. Allosteric competitive inhibitors of the glucose-1-phosphate Thymidylyltransferase (RmlA) from  seudomonas aeruginosa

    Alphey, M. S., Pirrie, L., Torrie, L. S., Boulkeroua, W. A., Gardiner, M., Sarkar, A., Maringer, M., Oehlmann, W., Brenk, R., Scherman, M. S., McNeil, M., Rejzek, M., Field, R. A., Singh, M., Gray, D., Westwood, N. J. & Naismith, J. H. 2012 In : ACS Chemical Biology.

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  221. Assessment of pseudomonas aeruginosa N-5,N-10-methylenetetrahydrofolate dehydrogenase - cyclohydrolase as a potential antibacterial drug target

    Eadsforth, T. C., Gardiner, M., Maluf, F. V., McElroy, S., James, D., Frearson, J., Gray, D. & Hunter, W. N. 2012 In : PLoS ONE. 7, 4, p. - 11 p., e35973

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  222. Avirulence protein 3a (AVR3a) from the potato pathogen Phytophthora infestans forms homodimers through its predicted translocation region and does not specifically bind phospholipids

    Wawra, S., Agacan, M., Boddey, J. A., Davidson, I., Gachon, C. M. M., Zanda, M., Grouffaud, S., Whisson, S. C., Birch, P. R. J., Porter, A. J. & Van West, P. 2012 In : Journal of Biological Chemistry. 287, 45, p. 38101-38109 9 p.

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  223. BioJava: an open-source framework for bioinformatics in 2012

    Prlic, A., Yates, A., Bliven, S. E., Rose, P. W., Jacobsen, J., Troshin, P. V., Chapman, M., Gao, J., Koh, C. H., Foisy, S., Holland, R., Rimsa, G., Heuer, M. L., Brandstaetter-Mueller, H., Bourne, P. E. & Willis, S. 2012 In : Bioinformatics. 28, 20, p. 2693-2695 3 p.

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  224. Change or be changed: reflections of the workshop 'Future in Medicinal Chemistry'

    Brenk, R. & Rauh, D. 2012 In : Bioorganic & Medicinal Chemistry. 20, 12, p. 3695-3697 3 p.

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  225. Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei

    Urbaniak, M. D., Mathieson, T., Bantscheff, M., Eberhard, D., Grimaldi, R., Miranda-Saavedra, D., Wyatt, P., Ferguson, M. A. J., Frearson, J. & Drewes, G. 2012 In : ACS Chemical Biology. 7, 11, p. 1858-1865 8 p.

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  226. Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo

    Wishart, T. M., Rooney, T. M., Lamont, D. J., Wright, A. K., Morton, A. J., Jackson, M., Freeman, M. R. & Gillingwater, T. H. 2012 In : PLoS Genetics. 8, 8

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  227. Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages

    Urbaniak, M. D., Guther, M. L. S. & Ferguson, M. A. J. 2012 In : PLoS ONE. 7, 5, p. - 8 p., e36619

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  228. Genetic diversity in European Pisum germplasm collections

    Jing, R., Ambrose, M. A., Knox, M. R., Smykal, P., Hybl, M., Ramos, A., Caminero, C., Burstin, J., Duc, G., van Soest, L. J. M., Swiecicki, W. K., Pereira, M. G., Vishnyakova, M., Davenport, G. F., Flavell, A. J. & Ellis, T. H. N. 2012 In : Theoretical and Applied Genetics. 125, 2, p. 367-380 14 p.

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  229. Guidelines for the use and interpretation of assays for monitoring autophagy

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  230. Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide- binding properties

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  231. Introduction: the case for polypharmacology

    Hopkins, A. L. 2012 Polypharmacology in drug discovery. Peters, J-U. (ed.). Hoboken: John Wiley & Sons, p. 1-6 6 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  232. IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening

    Tidten-Luksch, N., Grimaldi, R., Torrie, L. S., Frearson, J. A., Hunter, W. N. & Brenk, R. 2012 In : PLoS ONE. 7, 4, p. - 16 p., e35792

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  233. Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation

    Fyfe, P. K., Westrop, G. D., Silva, A. M., Coombs, G. H. & Hunter, W. N. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 29, p. 11693-11698 6 p.

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  234. Live imaging of nascent RNA dynamics reveals distinct types of transcriptional pulse regulation

    Muramoto, T., Cannon, D., Gierlinski, M., Corrigan, A., Barton, G. J. & Chubb, J. R. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 19, p. 7350-7355 6 p.

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  235. MSK1 regulates homeostatic and experience-dependent synaptic plasticity

    Corrêa, S. A. L., Hunter, C. J., Palygin, O., Wauters, S. C., Martin, K. J., McKenzie, C., McKelvey, K., Morris, R. G. M., Pankratov, Y., Arthur, J. S. C. & Frenguelli, B. 2012 In : Journal of Neuroscience. 32, 38, p. 13039-13051 13 p.

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  236. NUP-1 is a large coiled-coil nucleoskeletal protein in Trypanosomes with lamin-like functions

    DuBois, K. N., Alsford, S., Holden, J. M., Buisson, J., Swiderski, M., Bart, J-M., Ratushny, A. V., Wan, Y., Bastin, P., Barry, J. D., Navarro, M., Horn, D., Aitchison, J. D., Rout, M. P. & Field, M. C. 2012 In : PLoS Biology. 10, 3, 20 p., e1001287

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  237. O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

    Schimpl, M., Zheng, X., Borodkin, V. S., Blair, D. E., Ferenbach, A. T., Schüttelkopf, A. W., Navratilova, I., Aristotelous, T., Albarbarawi, O., Robinson, D. A., van Aalten, D. M. F. & Macnaughtan, M. A. 2012 In : Nature Chemical Biology.

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  238. Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase

    Bandini, G., Marino, K., Güther, M. L. S., Wernimont, A. K., Kuettel, S., Qiu, W., Afzal, S., Kelner, A., Hui, R. & Ferguson, M. A. J. 2012 In : Molecular Microbiology. 85, 3, p. 513-534 22 p.

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  239. PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

    Tibarewal, P., Zilidis, G., Spinelli, L., Schurch, N., Maccario, H., Gray, A., Perera, N. M., Davidson, L., Barton, G. J. & Leslie, N. R. 2012 In : Science Signaling. 5, 213, p. ra18

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  240. Structural and biochemical characterization of a trapped coenzyme a adduct of Caenorhabditis elegans glucosamine-6-phosphate N-acetyltransferase 1

    Dorfmueller, H. C., Fang, W., Rao, F. V., Blair, D. E., Attrill, H. & van Aalten, D. M. F. 2012 In : Acta Crystallographica Section D: Biological Crystallography. 68, 8, p. 1019-1029 11 p.

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  241. Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

    Cui, H., Carrero-Lérida, J., Silva, A. P. G., Whittingham, J. L., Brannigan, J. A., Ruiz-Pérez, L. M., Read, K. D., Wilson, K. S., González-Pacanowska, D. & Gilbert, I. H. 2012 In : Journal of Medicinal Chemistry. 55, 24, p. 10948-57 10 p.

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  242. Synthesis of novel tetrazole C5-linked C0- and C2-ribonucleoside phosphoramidites using MePOM and POM groups for probing RNA catalysis

    Harusawa, S., Yoneyama, H., Fujisue, D., Nishiura, M., Fujitake, M., Usami, Y., Zhao, Z., Mcphee, S. A., Wilson, T. J. & Lilley, D. M. J. 2012 In : Tetrahedron Letters. 53, 44, p. 5891-5894 4 p.

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  243. Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction

    Buckley, D. L., Van Molle, I., Gareiss, P. C., Tae, H. S., Michel, J., Noblin, D. J., Jorgensen, W. L., Ciulli, A. & Crews, C. M. 2012 In : Journal of the American Chemical Society. 134, 10, p. 4465-4468 4 p.

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  244. Telomeres, tethers and trypanosomes

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  245. The kinomes of apicomplexan parasites

    Miranda-Saavedra, D., Gabaldón, T., Barton, G. J., Langsley, G. & Doerig, C. 2012 In : Microbes and Infection. 14, 10, p. 796-810 15 p.

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  246. The structure and folding of helical junctions in RNA

    Lilley, D. M. J. 2012 Innovations in Biomolecular Modeling and Simulations. Schlick, T. (ed.). Cambridge: Royal Society of Chemistry, (RSC Biomolecular Sciences)

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  247. The structure and folding of kink turns in RNA

    Lilley, D. M. J. 2012 In : Wiley Interdisciplinary Reviews: RNA. 3, 6, p. 797-805 9 p.

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  248. The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces

    Wong, E., Vaaje-Kolstad, G., Ghosh, A., Hurtado-Guerrero, R., Konarev, P. V., Ibrahim, A. F. M., Svergun, D. I., Eijsink, V. G. H., Chatterjee, N. S. & van Aalten, D. M. F. 2012 In : PLoS Pathogens. 8, 1, e1002373

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  249. Investigation of copper(II) tetrafluoroborate catalysed epoxide opening

    Capes, A. S., Crossman, A. T., Webster, L. A., Ferguson, M. A. J. & Gilbert, I. H. 28 Dec 2011 In : Tetrahedron Letters. 52, 52, p. 7091-7094 4 p.

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  250. Protein O-GlcNAcylation is required for fibroblast growth factor signaling in Drosophila

    Mariappa, D., Sauert, K., Marino, K., Turnock, D., Webster, R., van Aalten, D. M. F., Ferguson, M. A. J. & Muller, H. A. J. 20 Dec 2011 In : Science Signaling. 4, 204, p. - 8 p., ra89

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  251. Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

    Cleghorn, L. A. T., Woodland, A., Collie, I. T., Torrie, L. S., Norcross, N., Luksch, T., Mpamhanga, C., Walker, R. G., Mottram, J. C., Brenk, R., Frearson, J. A., Gilbert, I. H. & Wyatt, P. G. 9 Dec 2011 In : ChemMedChem. 6, 12, p. 2214-2224 11 p.

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  252. Syringyl lignin is unaltered by severe sinapyl alcohol dehydrogenase suppression in tobacco

    Barakate, A., Stephens, J., Goldie, A., Hunter, W. N., Marshall, D., Hancock, R. D., Lapierre, C., Morreele, K., Boerjane, W. & Halpin, C. Dec 2011 In : Plant Cell. 23, 12, p. 4492-4506 15 p.

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  253. The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system

    Rao, V. A., Shepherd, S. M., English, G., Coulthurst, S. J. & Hunter, W. N. Dec 2011 In : Acta Crystallographica Section D: Biological Crystallography. 67, p. 1065-1072 8 p.

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  254. Chemical structure of Trichomonas vaginalis surface lipoglycan: a role for short galactose (beta 1-4/3) N-acetylglucosamine repeats in host cell interaction

    Ryan, C. M., Mehlert, A., Richardson, J. M., Ferguson, M. A. J. & Johnson, P. J. 25 Nov 2011 In : Journal of Biological Chemistry. 286, 47, p. 40494-40508 15 p.

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  255. Rab28 function in trypanosomes: interactions with retromer and ESCRT pathways

    Lumb, J. H., Leung, K. F., Dubois, K. N. & Field, M. C. 15 Nov 2011 In : Journal of Cell Science. 124, P22, p. 3771-3783 13 p.

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  256. From snoRNA to miRNA: Dual function regulatory non-coding RNAs

    Scott, M. S. & Ono, M. 1 Nov 2011 In : Biochimie. 93, 11, p. 1987-1992 6 p.

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  257. DrugPred: A Structure-Based Approach To Predict Protein Druggability Developed Using an Extensive Nonredundant Data Set

    Krasowski, A., Muthas, D., Sarkar, A., Schmitt, S. & Brenk, R. Nov 2011 In : Journal of Chemical Information and Modeling. 51, 11, p. 2829-2842 14 p.

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  258. The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin

    Chen, S., Synowsky, S., Tinti, M. & MacKintosh, C. Nov 2011 In : Trends in Endocrinology and Metabolism. 22, 11, p. 429-436 8 p.

    Research output: Contribution to journalScientific review

  259. Cell migration modulating compounds

    Schor, A. M., Schor, S. L., Marquez, R. & Norman, D. G. 19 Oct 2011 EP1917012

    Research output: Patent

  260. Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

    Patterson, S., Alphey, M. S., Jones, D. C., Shanks, E. J., Street, I. P., Frearson, J. A., Wyatt, P. G., Gilbert, I. H. & Fairlamb, A. H. 13 Oct 2011 In : Journal of Medicinal Chemistry. 54, 19, p. 6514-6530 17 p.

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  261. Design, Synthesis, and Evaluation of 5 '-Diphenyl Nucleoside Analogues as Inhibitors of the Plasmodium falciparum dUTPase

    Hampton, S. E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Alexander Musso-Buendia, J., Recio, E., Kaiser, M., Whittingham, J. L., Roberts, S. M., Shevtsov, M., Brannigan, J. A., Kahnberg, P., Brun, R., Wilson, K. S., Gonzalez-Pacanowska, D., Johansson, N. G. & Gilbert, I. H. 4 Oct 2011 In : ChemMedChem. 6, 10, p. 1816-1831 16 p.

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  262. Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

    Smith, V. C., Cleghorn, L. A. T., Woodland, A., Spinks, D., Hallyburton, I., Collie, I. T., Mok, N. Y., Norval, S., Brenk, R., Fairlamb, A. H., Frearson, J. A., Read, K. D., Gilbert, I. H. & Wyatt, P. G. 4 Oct 2011 In : ChemMedChem. 6, 10, p. 1832-1840 9 p.

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  263. Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery

    Philpott, M., Yang, J., Tumber, T., Fedorov, O., Uttarkar, S., Filippakopoulos, P., Picaud, S., Keates, T., Felletar, I., Ciulli, A., Knapp, S. & Heightman, T. D. 1 Oct 2011 In : Molecular BioSystems. 7, 10, p. 2899-2908 10 p.

    Research output: Contribution to journalArticle

  264. Emerging role of surface plasmon resonance in fragment-based drug discovery

    Navratilova, I. & Hopkins, A. L. Oct 2011 In : Future Medicinal Chemistry. 3, 14, p. 1809-1820 12 p.

    Research output: Contribution to journalScientific review

  265. Mining the ChEMBL Database: An Efficient Chemoinformatics Workflow for Assembling an Ion Channel-Focused Screening Library

    Mok, N. Y. & Brenk, R. Oct 2011 In : Journal of Chemical Information and Modeling. 51, 10, p. 2449-2454 6 p.

    Research output: Contribution to journalArticle

  266. On the hunt for new diagnostic antigens for human African trypanosomiasis

    Sullivan, L., Carrington, M. & Ferguson, M. A. J. Oct 2011 In : Tropical Medicine & International Health. 16, p. 201-201 1 p.

    Research output: Contribution to journalMeeting abstract

  267. Probing the Dynamic Nature of Water Molecules and Their Influences on Ligand Binding in a Model Binding Site

    Cappel, D., Wahlstroem, R., Brenk, R. & Sotriffer, C. A. Oct 2011 In : Journal of Chemical Information and Modeling. 51, 10, p. 2581-2594 14 p.

    Research output: Contribution to journalArticle

  268. Visceral leishmaniasis and arsenic: an ancient poison contributing to antimonial treatment failure in the Indian subcontinent?

    Perry, M., Wyllie, S., Prajapati, V. K., Feldmann, J., Sundar, S., Boelaert, M. & Fairlamb, A. H. Oct 2011 In : Tropical Medicine & International Health. 16, S1, p. 66-67 2 p.

    Research output: Contribution to journalBook/Film/Article review

  269. Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome

    Johnson, C., Tinti, M., Wood, N. T., Campbell, D. G., Toth, R., Dubois, F., Geraghty, K. M., Wong, B. H. C., Brown, L. J., Tyler, J., Gernez, A., Chen, S., Synowsky, S. & MacKintosh, C. Oct 2011 In : Molecular & Cellular Proteomics. 10, 10, p. - 15 p.

    Research output: Contribution to journalArticle

  270. A role for Snf2-related nucleosome-spacing enzymes in genome-wide nucleosome organization

    Gkikopoulos, T., Schofield, P., Singh, V., Pinskaya, M., Mellor, J., Smolle, M., Workman, J. L., Barton, G. J. & Owen-Hughes, T. 23 Sep 2011 In : Science. 333, 6050, p. 1758-1760 3 p.

    Research output: Contribution to journalArticle

  271. Pseudomonas aeruginosa 4-Amino-4-deoxychorismate lyase: spatial conservation of an active site tyrosine and classification of two types of enzyme

    O'Rourke, P. E. F., Eadsforth, T. C., Fyfe, P. K., Shepherd, S. M. & Hunter, W. N. 15 Sep 2011 In : PLoS ONE. 6, 9, p. - 8 p., e24158

    Research output: Contribution to journalArticle

  272. RNA Tertiary Interactions in a Riboswitch Stabilize the Structure of a Kink Turn

    Schroeder, K. T., Daldrop, P. & Lilley, D. M. J. 7 Sep 2011 In : Structure. 19, 9, p. 1233-1240 8 p.

    Research output: Contribution to journalArticle

  273. Computational approaches to selecting and optimising targets for structural biology

    Overton, I. M. & Barton, G. J. Sep 2011 In : Journal of Neuroscience Methods. 55, 1, p. 311 9 p.

    Research output: Contribution to journalArticle

  274. Mechanism of ubiquitylation by dimeric RING ligase RNF4

    Plechanovova, A., Jaffray, E. G., McMahon, S. A., Johnson, K. A., Navratilova, I., Naismith, J. H. & Hay, R. T. Sep 2011 In : Nature Structural & Molecular Biology. 18, 9, p. 1052-1059 8 p.

    Research output: Contribution to journalArticle

  275. Minimum information about a bioactive entity (MIABE)

    Orchard, S. , Al-Lazikani, B. , Bryant, S. , Clark, D. , Calder, E. , Dix, I. , Engkvist, O. , Forster, M. , Gaulton, A. , Gilson, M. , Glen, R. , Grigorov, M. , Hammond-Kosack, K. , Harland, L. , Hopkins, A. , Larminie, C. , Lynch, N. , Mann, R. K. , Murray-Rust, P. , Lo Piparo, E. & 6 others Southan, C., Steinbeck, C., Wishart, D., Hermjakob, H., Overington, J. & Thornton, J. Sep 2011 In : Nature Reviews Drug Discovery. 10, 9, p. 661-669 9 p.

    Research output: Contribution to journalScientific review

  276. Visceral Leishmaniasis and Arsenic: An Ancient Poison Contributing to Antimonial Treatment Failure in the Indian Subcontinent?

    Perry, M. R., Wyllie, S., Prajapati, V. K., Feldmann, J., Sundar, S., Boelaert, M. & Fairlamb, A. H. Sep 2011 In : PLoS Neglected Tropical Diseases. 5, 9, p. - 5 p., e1227

    Research output: Contribution to journalEditorial

  277. PChopper: high throughput peptide prediction for MRM/SRM transition design

    Afzal, V., Huang, J. T-J., Atrih, A. & Crowther, D. J. 15 Aug 2011 In : BMC Bioinformatics. 12, p. - 9 p., 338

    Research output: Contribution to journalArticle

  278. NoD: a Nucleolar localization sequence detector for eukaryotic and viral proteins

    Scott, M. S., Troshin, P. V. & Barton, G. J. 3 Aug 2011 In : BMC Bioinformatics. 12, p. - 7 p., 317

    Research output: Contribution to journalArticle

  279. Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites

    Hunter, W. N. Aug 2011 In : Current Topics in Medicinal Chemistry. 11, 16, p. 2048-2059 12 p.

    Research output: Contribution to journalScientific review

  280. Regulation of Caenorhabditis elegans p53/CEP-1-Dependent Germ Cell Apoptosis by Ras/MAPK Signaling

    Rutkowski, R., Dickinson, R., Stewart, G., Craig, A., Schimpl, M., Keyse, S. M. & Gartner, A. Aug 2011 In : PLoS Genetics. 7, 8, p. - 21 p., e1002238

    Research output: Contribution to journalArticle

  281. The impact of dedicated dermatology services on the awareness of cutaneous cancer risk and on attitudes towards UV exposure among transplant recipients

    Casabonne, D., Newton, R., Ismail, F., Mitchell, L., Lally, A., Imko-Walczuk, B., Wojnarowska, F., Proby, C. & Harwood, C. Aug 2011 In : Journal of Epidemiology and Community Health. 65, p. A107-A107 1 p.

    Research output: Contribution to journalBook/Film/Article review

  282. Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database

    Bickerton, G. R., Higueruelo, A. P. & Blundell, T. L. 29 Jul 2011 In : BMC Bioinformatics. 12, p. - 14 p., 313

    Research output: Contribution to journalArticle

  283. Java bioinformatics analysis web services for multiple sequence alignment-JABAWS:MSA

    Troshin, P. V., Procter, J. B. & Barton, G. J. 15 Jul 2011 In : BMC Bioinformatics. 27, 14, p. 2001-2002 2 p.

    Research output: Contribution to journalArticle

  284. The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains

    Ryan, D. P., Sundaramoorthy, R., Martin, D., Singh, V. & Owen-Hughes, T. 6 Jul 2011 In : EMBO Journal. 30, 13, p. 2596-2609 14 p.

    Research output: Contribution to journalArticle

  285. Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei

    Marino, K., Guther, M. L. S., Wernimont, A. K., Qiu, W., Hui, R. & Ferguson, M. A. J. Jul 2011 In : Eukaryotic Cell. 10, 7, p. 985-997 13 p.

    Research output: Contribution to journalArticle

  286. Screening for GPCR Ligands Using Surface Plasmon Resonance

    Hopkins Navratilova, I., Besnard, J. & Hopkins, A. L. Jul 2011 In : ACS Medicinal Chemistry Letters. 2, 7, p. 549-554 6 p.

    Research output: Contribution to journalArticle

  287. Synthetic Neoglycoconjugates of Cell-Surface Phosphoglycans of Leishmania as Potential Anti-parasite Carbohydrate Vaccines

    Nikolaev, A. V. & Sizova, O. V. Jul 2011 In : Biochemistry-Moscow. 76, 7, p. 761-773 13 p.

    Research output: Contribution to journalScientific review

  288. The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential for novel treatments for schizophrenia

    Large, C. H., Bison, S., Sartori, I., Read, K. D., Gozzi, A., Quarta, D., Antolini, M., Hollands, E., Gill, C. H., Gunthorpe, M. J., Idris, N., Neill, J. C. & Alvaro, G. S. Jul 2011 In : Journal of Pharmacology and Experimental Therapeutics. 338, 1, p. 100-113 14 p.

    Research output: Contribution to journalArticle

  289. Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

    Dow, G. S. , Milner, E. , Bathurst, I. , Bhonsle, J. , Caridha, D. , Gardner, S. , Gerena, L. , Kozar, M. , Lanteri, C. , Mannila, A. , McCalmont, W. , Moon, J. , Read, K. D. , Norval, S. , Roncal, N. , Shackleford, D. M. , Sousa, J. , Steuten, J. , White, K. L. , Zeng, Q. & 1 others Charman, S. A. 6 Jun 2011 In : Malaria Journal. 10, p. - 11 p., 150

    Research output: Contribution to journalArticle

  290. Antimicrobial drug discovery

    Fairlamb, A. & Cole, S. Jun 2011 In : Future Microbiology. 6, 6, p. 601-602 2 p.

    Research output: Contribution to journalEditorial

  291. Bisdionin C-A rationally designed, submicromolar inhibitor of family 18 chitinases

    Schuettelkopf, A. W., Andersen, O. A., Rao, F. V., Allwood, M., Rush, C. L., Eggleston, I. M. & van Aalten, D. M. F. Jun 2011 In : ACS Medicinal Chemistry Letters. 2, 6, p. 428-432 5 p.

    Research output: Contribution to journalArticle

  292. High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

    Alsford, S., Turner, D. J., Obado, S. O., Sanchez-Flores, A., Glover, L., Berriman, M., Hertz-Fowler, C. & Horn, D. Jun 2011 In : Genome Research. 21, 6, p. 915-924 10 p.

    Research output: Contribution to journalArticle

  293. Probing Elongating and Branching beta-D-Galactosyltransferase Activities in Leishmania Parasites by Making Use of Synthetic Phosphoglycans

    Sizova, O. V., Ross, A. J., Ivanova, I. A., Borodkin, V. S., Ferguson, M. A. J. & Nikolaev, A. V. Jun 2011 In : ACS Chemical Biology. 6, 6, p. 648-657 10 p.

    Research output: Contribution to journalArticle

  294. Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor

    Sutherland, T. E., Andersen, O. A., Betou, M., Eggleston, I. M., Maizels, R. M., van Aalten, D. & Allen, J. E. 27 May 2011 In : Chemistry & Biology. 18, 5, p. 569-579 11 p.

    Research output: Contribution to journalArticle

  295. Design of molecules

    Hopkins, A. & Besnard, J. 26 May 2011 PCT/GB2010/051940

    Research output: Patent

  296. The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4

    Gkikopoulos, T., Singh, V., Tsui, K., Awad, S., Renshaw, M. J., Scholfield, P., Barton, G. J., Nislow, C., Tanaka, T. U. & Owen-Hughes, T. 18 May 2011 In : EMBO Journal. 30, 10, p. 1919-1927 9 p.

    Research output: Contribution to journalArticle

  297. A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation

    Sugden, C., Ross, S., Annesley, S. J., Cole, C., Bloomfield, G., Ivens, A., Skelton, J., Fisher, P. R., Barton, G. & Williams, J. G. 15 May 2011 In : Developmental Biology. 353, 2, p. 290-301 12 p.

    Research output: Contribution to journalArticle

  298. Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus

    Overton, I. M., Graham, S., Gould, K. A., Hinds, J., Botting, C. H., Shirran, S., Barton, G. J. & Coote, P. J. 12 May 2011 In : BMC Systems Biology. 5, p. - 16 p., 68

    Research output: Contribution to journalArticle

  299. Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate

    Morgan, R. E., Batot, G. O., Dement, J. M., Rao, V. A., Eadsforth, T. C. & Hunter, W. N. 9 May 2011 In : BMC Structural Biology. 11, p. - 9 p., 21

    Research output: Contribution to journalArticle

  300. MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

    Filippi, B. M., de los Heros, P., Mehellou, Y., Navratilova, I., Gourlay, R., Deak, M., Plater, L., Toth, R., Zeqiraj, E. & Alessi, D. R. 4 May 2011 In : EMBO Journal. 30, 9, p. 1730-1741 12 p.

    Research output: Contribution to journalArticle

  301. Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei

    Abdelwahab, N. Z., Urbaniak, M. D., Ferguson, M. A. J. & Crossman, A. T. 1 May 2011 In : Carbohydrate Research. 346, 6, p. 708-714 7 p.

    Research output: Contribution to journalArticle

  302. Elongator protein 3b negatively regulates ribosomal DNA transcription in African Trypanosomes

    Alsford, S. & Horn, D. May 2011 In : Molecular and Cellular Biology. 31, 9, p. 1822-1832 11 p.

    Research output: Contribution to journalArticle

  303. Finding New Hits in Neglected Disease Projects: Target or Phenotypic Based Screening?

    Gilbert, I. H., Leroy, D. & Frearson, J. A. May 2011 In : Current Topics in Medicinal Chemistry. 11, 10, p. 1284-1291 8 p.

    Research output: Contribution to journalScientific review

  304. Identification of human miRNA precursors that resemble box C/D snoRNAs

    Ono, M., Scott, M. S., Yamada, K., Avolio, F., Barton, G. J. & Lamond, A. I. May 2011 In : Nucleic Acids Research. 39, 9, p. 3879-3891 13 p.

    Research output: Contribution to journalArticle

  305. Methylglyoxal metabolism in trypanosomes and leishmania

    Wyllie, S. & Fairlamb, A. H. May 2011 In : Seminars in Cell & Developmental Biology. 22, 3, p. 271-277 7 p.

    Research output: Contribution to journalScientific review

  306. Progress in Neglected Disease Drug Discovery

    Hopkins, A. L. & Wyatt, P. G. May 2011 In : Current Topics in Medicinal Chemistry. 11, 10, p. 1215-1215 1 p.

    Research output: Contribution to journalEditorial

  307. Rapid Analysis of Pharmacology for Infectious Diseases

    Hopkins, A. L., Bickerton, G. R., Carruthers, I. M., Boyer, S. K., Rubin, H. & Overington, J. P. May 2011 In : Current Topics in Medicinal Chemistry. 11, 10, p. 1292-1300 9 p.

    Research output: Contribution to journalScientific review

  308. Target Validation: Linking Target and Chemical Properties to Desired Product Profile

    Wyatt, P. G., Gilbert, I. H., Read, K. D. & Fairlamb, A. H. May 2011 In : Current Topics in Medicinal Chemistry. 11, 10, p. 1275-1283 9 p.

    Research output: Contribution to journalScientific review

  309. Exploiting the high-resolution crystal structure of Staphylococcus aureus MenH to gain insight into enzyme activity

    Dawson, A., Fyfe, P. K., Gillet, F. & Hunter, W. N. 22 Apr 2011 In : BMC Structural Biology. 11, p. - 11 p., 19

    Research output: Contribution to journalArticle

  310. Evaluation of three novel azasterols against Toxoplasma gondii

    Martins-Duarte, É. S., Lemgruber, L., de Souza, W., Vommaro, R. C., Lorente, S. O., Gros, L., Magaraci, F. & Gilbert, I. H. 19 Apr 2011 In : Veterinary Parasitology. 177, 1-2, p. 157-161 5 p.

    Research output: Contribution to journalArticle

  311. beta-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase

    Baragana, B., McCarthy, O., Sanchez, P., Bosch-Navarrete, C., Kaiser, M., Brun, R., Whittingham, J. L., Roberts, S. M., Zhou, X-X., Wilson, K. S., Johansson, N. G., Gonzalez-Pacanowska, D. & Gilbert, I. H. 1 Apr 2011 In : Bioorganic & Medicinal Chemistry. 19, 7, p. 2378-2391 14 p.

    Research output: Contribution to journalArticle

  312. Developing small molecule drugs to rescue nonsense mutations in disease-causing genes

    Nomura, T., Gartner, U., McElroy, S., Torrie, L., Pourreyron, C., South, A. P., Wood, G., Woodland, A., Frearson, J., Wyatt, P. & McLean, I. Apr 2011 In : Journal of Investigative Dermatology. 131, p. S67-S67 1 p., 397

    Research output: Contribution to journalBook/Film/Article review

  313. XANNpred: Neural nets that predict the propensity of a protein to yield diffraction-quality crystals

    Overton, I. M., van Niekerk, C. A. J. & Barton, G. J. Apr 2011 In : Proteins: Structure, Function, and Bioinformatics. 79, 4, p. 1027-1033 7 p.

    Research output: Contribution to journalArticle

  314. Effect of PI3K-and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKBI-deficient mice

    Garcia-Martinez, J. M., Wullschleger, S., Preston, G., Guichard, S., Fleming, S., Alessi, D. R. & Duce, S. L. 29 Mar 2011 In : British Journal of Cancer. 104, 7, p. 1116-1125 10 p.

    Research output: Contribution to journalArticle

  315. Dissecting the Metabolic Roles of Pteridine Reductase 1 in Trypanosoma brucei and Leishmania major

    Ong, H. B., Sienkiewicz, N., Wyllie, S. & Fairlamb, A. H. 25 Mar 2011 In : Journal of Biological Chemistry. 286, 12, p. 10429-10438 10 p.

    Research output: Contribution to journalArticle

  316. Novel Ligands for a Purine Riboswitch Discovered by RNA-Ligand Docking

    Daldrop, P., Reyes, F. E., Robinson, D. A., Hammond, C. M., Lilley, D. M., Batey, R. T. & Brenk, R. 25 Mar 2011 In : Chemistry & Biology. 18, 3, p. 324-335 12 p.

    Research output: Contribution to journalArticle

  317. Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism

    Konig, J., Wyllie, S., Wells, G., Stevens, M. F., Wyatt, P. G. & Fairlamb, A. H. 11 Mar 2011 In : Journal of Biological Chemistry. 286, 10, p. 8523-8533 11 p.

    Research output: Contribution to journalArticle

  318. PIMS sequencing extension: a laboratory information management system for DNA sequencing facilities

    Troshin, P. V., Postis, V. L. G., Ashworth, D., Baldwin, S. A., McPherson, M. J. & Barton, G. J. 7 Mar 2011 In : BMC Research Notes. 4, 9 p., 48

    Research output: Contribution to journalArticle

  319. Multiwall carbon nanotubes as MRI contrast agents for tracking stem cells

    Vittorio, O., Duce, S. L., Pietrabissa, A. & Cuschieri, A. 4 Mar 2011 In : Nanotechnology. 22, 9, p. - 7 p., 095706

    Research output: Contribution to journalArticle

  320. Microhomology-mediated deletion and gene conversion in African trypanosomes

    Glover, L., Jun, J. & Horn, D. Mar 2011 In : Nucleic Acids Research. 39, 4, p. 1372-1380 9 p.

    Research output: Contribution to journalArticle

  321. Molecular recognition: O-GlcNAc transfer: size matters

    Gay, L. M., Zheng, X. & van Aalten, D. M. F. Mar 2011 In : Nature Chemical Biology. 7, 3, p. 134-135 3 p.

    Research output: Contribution to journalComment/debate

  322. Substrate and product analogues as human O-GlcNAc transferase inhibitors

    Dorfmueller, H. C., Borodkin, V. S., Blair, D. E., Pathak, S., Navratilova, I. & van Aalten, D. M. F. Mar 2011 In : Amino Acids. 40, 3, p. 781-792 12 p.

    Research output: Contribution to journalArticle

  323. Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

    Spinks, D., Ong, H. B., Mpamhanga, C. P., Shanks, E. J., Robinson, D. A., Collie, I. T., Read, K. D., Frearson, J. A., Wyatt, P. G., Brenk, R., Fairlamb, A. H. & Gilbert, I. H. 7 Feb 2011 In : ChemMedChem. 6, 2, p. 302-308 7 p.

    Research output: Contribution to journalArticle

  324. Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase

    Walton, J. G. A., Jones, D. C., Kiuru, P., Durie, A. J., Westwood, N. J. & Fairlamb, A. H. 7 Feb 2011 In : ChemMedChem. 6, 2, p. 321-328 8 p.

    Research output: Contribution to journalArticle

  325. PNAC: a protein nucleolar association classifier

    Scott, M. S., Boisvert, F-M., Lamond, A. I. & Barton, G. J. 27 Jan 2011 In : BMC Genomics. 12, p. - 14 p., 74

    Research output: Contribution to journalArticle

  326. Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms

    Sainsbury, S., Bird, L., Rao, V., Shepherd, S. M., Stuart, D. I., Hunter, W. N., Owens, R. J. & Ren, J. 7 Jan 2011 In : Journal of Molecular Biology. 405, 1, p. 173-184 12 p.

    Research output: Contribution to journalArticle

  327. How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance

    Wullschleger, S., Sakamoto, K., Johnstone, L., Duce, S., Fleming, S. & Alessi, D. R. Jan 2011 In : Disease Models & Mechanisms. 4, 1, p. 95-103 9 p.

    Research output: Contribution to journalArticle

  328. Micro-magnetic resonance imaging study of live quail embryos during embryonic development

    Duce, S., Morrison, F., Welten, M., Baggott, G. & Tickle, C. Jan 2011 In : Magnetic Resonance Imaging. 29, 1, p. 132-139 8 p.

    Research output: Contribution to journalArticle

  329. Structure of recombinant Leishmania donovani pteridine reductase reveals a disordered active site

    Barrack, K. L., Tulloch, L. B., Burke, L-A., Fyfe, P. K. & Hunter, W. N. Jan 2011 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 67, p. 33-37 5 p.

    Research output: Contribution to journalArticle

  330. Triclosan is minimally effective in rodent malaria models

    Baschong, W., Wittlin, S., Inglis, K. A., Fairlamb, A. H., Croft, S. L., Kumar, T. R. S., Fidock, D. A. & Brun, R. Jan 2011 In : Nature Medicine. 17, 1, p. 33-34 2 p.

    Research output: Contribution to journalLetter

  331. Characterization of in vivo metabolites of WR319691, a novel compound with activity against Plasmodium falciparum

    Milner, E., Sousa, J., Pybus, B., Melendez, V., Gardner, S., Grauer, K., Moon, J., Carroll, D., Auschwitz, J., Gettayacamin, M., Lee, P., Leed, S., McCalmont, W., Norval, S., Tungtaeng, A., Zeng, Q., Kozar, M., Read, K. D., Li, Q. & Dow, G. 2011 In : European Journal of Drug Metabolism and Pharmacokinetics. 36, 3, p. 151-158 8 p.

    Research output: Contribution to journalArticle

  332. Comparison of the specificity of Trk inhibitors in recombinant and neuronal assays

    Martin, K. J., Shpiro, N., Traynor, R., Elliott, M. & Arthur, J. S. C. 2011 In : Neuropharmacology. 61, 1-2, p. 148-155 8 p.

    Research output: Contribution to journalArticle

  333. Drug discovery initiative at the University of Dundee: hit-to-lead development for hat and generation of chemical tools

    Grimaldi, R., Urich, R., Sienkiewicz, N., Woodland, A., Urbaniak, M. D., Mathieson, T., Eberhard, D., Bantscheff, M., Drewes, G., Ferguson, M. A. J., Gilbert, I. H., Frearson, J. A., Wyatt, P. G. & Fairlamb, A. H. 2011 In : Tropical Medicine & International Health. 16, S.1, p. 212 1 p., 1.3-148

    Research output: Contribution to journalMeeting abstract

  334. Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6

    Baker, N., Alsford, S. & Horn, D. 2011 In : Molecular and Biochemical Parasitology. 176, 1, p. 55-57 3 p.

    Research output: Contribution to journalArticle

  335. Modified 5'-trityl nucleosides as inhibitors of plasmodium falciparum dUTPase

    Ruda, G. F., Nguyen, C., Ziemkowski, P., Felczak, K., Kasinathan, G., Musso-Buendia, A., Sund, C., Zhou, X. X., Kaiser, M., Ruiz-Pérez, L. M., Brun, R., Kulikowski, T., Johansson, N. G., González-Pacanowska, D. & Gilbert, I. H. 2011 In : ChemMedChem. 6, 2, p. 309-320 12 p.

    Research output: Contribution to journalArticle

  336. Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPase

    Recio, E., Musso-Buendía, A., Vidal, A. E., Ruda, G. F., Kasinathan, G., Nguyen, C., Ruiz-Pérez, L. M., Gilbert, I. H. & González-Pacanowska, D. 2011 In : European Journal of Medicinal Chemistry. 46, 8, p. 3309-3314 6 p.

    Research output: Contribution to journalArticle

  337. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis

    Dias, M. V. B., Snee, W. C., Bromfield, K. M., Payne, R. J., Palaninathan, S. K., Ciulli, A., Howard, N. I., Abell, C., Sacchettini, J. C. & Blundell, T. L. 2011 In : Biochemical Journal. 436, 3, p. 729-739 11 p.

    Research output: Contribution to journalArticle

  338. Synthetic glycosylphosphatidylinositol (GPI) anchors: how these complex molecules have been made

    Nikolaev, A. V. & Al-Maharik, N. 2011 In : Natural Product Reports. 28, 5, p. 970-1020 51 p.

    Research output: Contribution to journalScientific review

  339. Acetazolamide-based fungal chitinase inhibitors

    Schuettelkopf, A. W., Gros, L., Blair, D. E., Frearson, J. A., van Aalten, D. M. F. & Gilbert, I. H. 1 Dec 2010 In : Bioorganic & Medicinal Chemistry. 18, 23, p. 8334-8340 7 p.

    Research output: Contribution to journalArticle

  340. Crystal structure of Leishmania major ADP-ribosylation factor-like 1 and a classification of related GTPase family members in this Kinetoplastid

    Fleming, J. R., Dawson, A. & Hunter, W. N. Dec 2010 In : Molecular and Biochemical Parasitology. 174, 2, p. 141-144 4 p.

    Research output: Contribution to journalArticle

  341. Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase

    Marino, K., Guther, M. L. S., Wernimont, A. K., Amani, M., Hui, R. & Ferguson, M. A. J. Dec 2010 In : Glycobiology. 20, 12, p. 1619-1630 12 p.

    Research output: Contribution to journalArticle

  342. Molecular mechanisms underlying the control of antigenic variation in African trypanosomes

    Horn, D. & McCulloch, R. Dec 2010 In : Current Opinion in Microbiology. 13, 6, p. 700-705 6 p.

    Research output: Contribution to journalScientific review

  343. Pseudokinases-remnants of evolution or key allosteric regulators?

    Zeqiraj, E. & van Aalten, D. M. F. Dec 2010 In : Current Opinion in Structural Biology. 20, 6, p. 772-781 10 p.

    Research output: Contribution to journalArticle

  344. Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases

    Dorfmueller, H. C., Borodkin, V. S., Schimpl, M., Zheng, X., Kime, R., Read, K. D. & van Aalten, D. M. F. 24 Nov 2010 In : Chemistry & Biology. 17, 11, p. 1250-1255 6 p.

    Research output: Contribution to journalArticle

  345. Human OGA binds substrates in a conserved peptide recognition groove

    Schimpl, M., Schuettelkopf, A. W., Borodkin, V. S. & van Aalten, D. M. F. 15 Nov 2010 In : Biochemical Journal. 432, p. 1-7 7 p.

    Research output: Contribution to journalArticle

  346. Identification of a kappa-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

    Jones, D. C., Hallyburton, I., Stojanovski, L., Read, K. D., Frearson, J. A. & Fairlamb, A. H. 15 Nov 2010 In : Biochemical Pharmacology. 80, 10, p. 1478-1486 9 p.

    Research output: Contribution to journalArticle

  347. High-resolution whole-genome sequencing reveals that specific Chromatin Domains from most human chromosomes associate with nucleoli

    van Koningsbruggen, S., Gierlinski, M., Schofield, P., Martin, D., Barton, G. J., Ariyurek, Y., den Dunnen, J. T. & Lamond, A. I. 1 Nov 2010 In : Molecular Biology of the Cell. 21, 21, p. 3735-3748 14 p.

    Research output: Contribution to journalArticle

  348. A high-throughput in vitro screen to identify inhibitors of the trypanosoma brucei trypananthione synthethase activity

    Kramer, M., Torrie, L., Booker, M., Spinks, D., Barker, R. H., Oza, S., Harris, M., Frearson, J., Collie, I. & Fairlamb, A. Nov 2010 In : American Journal of Tropical Medicine and Hygiene. 83, 5 (Suppl.), p. 323-323 1 p., 1083

    Research output: Contribution to journalBook/Film/Article review

  349. Central nervous system (CNS) exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous (IV) dosing in mice

    Dow, G. S., Milner, E., Caridha, D., Gardner, S., Lanteri, C., Kozar, M., Mannila, A., McCalmont, W., Melendez, V., Moon, J., Read, K., Norval, S., Roncal, N., Shackleford, D., Sousa, J., Stouten, J., White, K., Zeng, Q. & Charman, S. Nov 2010 p. 213-213 1 p.

    Research output: Contribution to conferenceAbstract

  350. Characterization and prediction of protein nucleolar localization sequences

    Scott, M. S., Boisvert, F-M., McDowall, M. D., Lamond, A. I. & Barton, G. J. Nov 2010 In : Nucleic Acids Research. 38, 21, p. 7388-7399 12 p.

    Research output: Contribution to journalArticle

  351. Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase

    Cui, H., Ruda, G. F., Carrero-Lerida, J., Ruiz-Perez, L. M., Gilbert, I. H. & Gonzalez-Pacanowska, D. Nov 2010 In : European Journal of Medicinal Chemistry. 45, 11, p. 5140-5149 10 p.

    Research output: Contribution to journalArticle

  352. Glycoinositolphosphorylceramide from Pathogenic Fungus Sporothrix schenckii Shows That Fatty Acid Hydroxylation Level Correlates with the Mycelium-Yeast Thermal-Induced Morphological Transition

    Medeiros, A., Bandini, G., Macedo, C., Ferguson, M., Kirsch, S., Soltwisch, J., Previato, J., Mendonca-Previato, L. & Peter-Katalinic, J. Nov 2010 In : Glycobiology. 20, 11, p. 1506-1506 1 p.

    Research output: Contribution to journalMeeting abstract

  353. Glycotyping of Trypanosoma brucei variant surface glycoprotein MITat1.8

    Mehlert, A., Sullivan, L. & Ferguson, M. A. J. Nov 2010 In : Molecular and Biochemical Parasitology. 174, 1, p. 74-77 4 p.

    Research output: Contribution to journalArticle

  354. O-Glcnacase substrate recognition involves both sugar and protein

    Schimpl, M., Schuettelkopf, A., Borodkin, V. S. & Van Aalten, D. M. F. Nov 2010 In : Glycobiology. 20, 11, p. 1481-1481 1 p., 101

    Research output: Contribution to journalBook/Film/Article review

  355. O-Glcnacylation of TAB1 modulates TAK1-mediated cytokine release

    Pathak, S., Campbell, D., Ibrahim, A. & Van Aalten, D. M. F. Nov 2010 In : Glycobiology. 20, 11, p. 1478-1478 1 p., 92

    Research output: Contribution to journalBook/Film/Article review

  356. RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease

    Alsford, S., Kemp, L. E., Kawahara, T. & Horn, D. Nov 2010 In : Molecular and Biochemical Parasitology. 174, 1, p. 70-73 4 p.

    Research output: Contribution to journalArticle

  357. Engineered biocompatible nanoparticles for in vivo imaging applications

    Chen, S., Wang, L., Duce, S. L., Brown, S., Lee, S., Melzer, A., Cuschieri, A. & Andre, P. 27 Oct 2010 In : Journal of the American Chemical Society. 132, 42, p. 15022-15029 8 p.

    Research output: Contribution to journalArticle

  358. Design and preparation of sterol mimetics as potential antiparasitics

    Gigante, F., Kaiser, M., Brun, R. & Gilbert, I. H. 15 Oct 2010 In : Bioorganic & Medicinal Chemistry. 18, 20, p. 7291-7301 11 p.

    Research output: Contribution to journalArticle

  359. Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum

    Cui, H., Ruiz-Perez, L. M., Gonzalez-Pacanowska, D. & Gilbert, I. H. 15 Oct 2010 In : Bioorganic & Medicinal Chemistry. 18, 20, p. 7302-7309 8 p.

    Research output: Contribution to journalArticle

  360. Drug discovery in academia: the third way?

    Frearson, J. & Wyatt, P. Oct 2010 In : Expert Opinion on Drug Discovery. 5, 10, p. 909-919 11 p.

    Research output: Contribution to journalScientific review

  361. Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates

    Wyllie, S., Mandal, G., Singh, N., Sundar, S., Fairlamb, A. H. & Chatterjee, M. Oct 2010 In : Molecular and Biochemical Parasitology. 173, 2, p. 162-164 3 p.

    Research output: Contribution to journalArticle

  362. Prophossi: automating expert validation of phosphopeptide-spectrum matches from tandem mass spectrometry

    Martin, D. M. A., Nett, I. R. E., Vandermoere, F., Barber, J. D., Morrice, N. A. & Ferguson, M. A. J. 1 Sep 2010 In : Bioinformatics. 26, 17, p. 2153-2159 7 p.

    Research output: Contribution to journalArticle

  363. Histone deacetylases play distinct roles in telomeric VSG expression site silencing in African trypanosomes

    Wang, Q-P., Kawahara, T. & Horn, D. Sep 2010 In : Molecular Microbiology. 77, 5, p. 1237-1245 9 p.

    Research output: Contribution to journalArticle

  364. Structure and reactivity of Bacillus subtilis MenD catalyzing the first committed step in menaquinone biosynthesis

    Dawson, A., Chen, M., Fyfe, P. K., Guo, Z. & Hunter, W. N. 13 Aug 2010 In : Journal of Molecular Biology. 401, 2, p. 253-264 12 p.

    Research output: Contribution to journalArticle

  365. Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif

    Klee, N., Wong, P. E., Baragana, B., El Mazouni, F., Phillips, M. A., Barrett, M. P. & Gilbert, I. H. 1 Aug 2010 In : Bioorganic & Medicinal Chemistry Letters. 20, 15, p. 4364-4366 3 p.

    Research output: Contribution to journalArticle

  366. Potentiation of the anticonvulsant efficacy of sodium channel inhibitors by an NK1-receptor antagonist in the rat

    Kalinichev, M., Bradford, A., Bison, S., Lucas, A., Sartori, I., Garbati, N., Andreetta, F., Bate, S., Austin, N. E., Jones, D. N. C., Read, K. D., Alvaro, G. & Large, C. H. Aug 2010 In : Epilepsia. 51, 8, p. 1543-1551 9 p.

    Research output: Contribution to journalArticle

  367. Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery

    Fyfe, P. K., Dawson, A., Hutchison, M-T., Cameron, S. & Hunter, W. N. Aug 2010 In : Acta Crystallographica Section D: Biological Crystallography. 66, p. 881-888 8 p.

    Research output: Contribution to journalArticle

  368. Structure of the three-way helical junction of the hepatitis C virus IRES element

    Ouellet, J., Melcher, S., Iqbal, A., Ding, Y. & Lilley, D. M. J. Aug 2010 In : RNA: a Publication of the RNA Society. 16, 8, p. 1597-1609 13 p.

    Research output: Contribution to journalArticle

  369. Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice

    Sienkiewicz, N., Ong, H. B. & Fairlamb, A. H. Aug 2010 In : Molecular Microbiology. 77, 3, p. 658-671 14 p.

    Research output: Contribution to journalArticle

  370. 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor

    Micheli, F. , Cavanni, P. , Andreotti, D. , Arban, R. , Benedetti, R. , Bertani, B. , Bettati, M. , Bettelini, L. , Bonanomi, G. , Braggio, S. , Carletti, R. , Checchia, A. , Corsi, M. , Fazzolari, E. , Fontana, S. , Marchioro, C. , Merlo-Pich, E. , Negri, M. , Oliosi, B. , Ratti, E. & 11 others Read, K. D., Roscic, M., Sartori, I., Spada, S., Tedesco, G., Tarsi, L., Terreni, S., Visentini, F., Zocchi, A., Zonzini, L. & Di Fabio, R. 8 Jul 2010 In : Journal of Medicinal Chemistry. 53, 13, p. 4989-5001 13 p.

    Research output: Contribution to journalArticle

  371. A fluorescence lifetime-based assay for serine and threonine kinases that is suitable for high-throughput screening

    Paterson, M. J., Dunsmore, C. J., Hurteaux, R., Maltman, B. A., Cotton, G. J. & Gray, A. 1 Jul 2010 In : Analytical Biochemistry. 402, 1, p. 54-64 11 p.

    Research output: Contribution to journalArticle

  372. Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis

    Sokolova, A. Y., Wyllie, S., Patterson, S., Oza, S. L., Read, K. D. & Fairlamb, A. H. Jul 2010 In : Antimicrobial Agents and Chemotherapy. 54, 7, p. 2893-2900 8 p.

    Research output: Contribution to journalArticle

  373. Know your chemical space

    Hopkins, A. L. & Bickerton, G. R. Jul 2010 In : Nature Chemical Biology. 6, 7, p. 482-483 2 p.

    Research output: Contribution to journalComment/debate

  374. Structural basis for the efficient phosphorylation of AZT-MP (3 '-azido-3 '-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

    Whittingham, J. L., Carrero-Lerida, J., Brannigan, J. A., Ruiz-Perez, L. M., Silva, A. P. G., Fogg, M. J., Wilkinson, A. J., Gilbert, I. H., Wilson, K. S. & Gonzalez-Pacanowska, D. 15 Jun 2010 In : Biochemical Journal. 428, p. 499-509 11 p.

    Research output: Contribution to journalArticle

  375. Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors

    Wang, S. , Midgley, C. A. , Scaërou, F. , Grabarek, J. B. , Griffiths, G. , Jackson, W. , Kontopidis, G. , McClue, S. J. , McInnes, C. , Meades, C. , Mezna, M. , Plater, A. , Stuart, I. , Thomas, M. P. , Wood, G. , Clarke, R. G. , Blake, D. G. , Zheleva, D. I. , Lane, D. P. , Jackson, R. C. & 2 others Glover, D. M. & Fischer, P. M. 10 Jun 2010 In : Journal of Medicinal Chemistry. 53, 11, p. 4367-4378 12 p.

    Research output: Contribution to journalArticle

  376. Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins

    Remenyi, J., Hunter, C. J., Cole, C., Ando, H., Impey, S., Monk, C. E., Martin, K. J., Barton, G. J., Hutvagner, G. & Arthur, J. S. C. 1 Jun 2010 In : Biochemical Journal. 428, 2, p. 281-291 11 p.

    Research output: Contribution to journalArticle

  377. Nucleophilic catalysis of acylhydrazone equilibration for protein-directed dynamic covalent chemistry

    Bhat, V. T., Caniard, A. M., Luksch, T., Brenk, R., Campopiano, D. J. & Greaney, M. F. Jun 2010 In : Nature Chemistry. 2, 6, p. 490-497 8 p.

    Research output: Contribution to journalArticle

  378. Nuclear DBF-2-related Kinases Are Essential Regulators of Cytokinesis in Bloodstream Stage Trypanosoma brucei

    Ma, J., Benz, C., Grimaldi, R., Stockdale, C., Wyatt, P., Frearson, J. & Hammarton, T. C. 14 May 2010 In : Journal of Biological Chemistry. 285, 20, p. 15356-15368 13 p.

    Research output: Contribution to journalArticle

  379. Analysis of Human Small Nucleolar RNAs (snoRNA) and the Development of snoRNA Modulator of Gene Expression Vectors

    Ono, M., Yamada, K., Avolio, F., Scott, M. S., van Koningsbruggen, S., Barton, G. J. & Lamond, A. I. 1 May 2010 In : Molecular Biology of the Cell. 21, 9, p. 1569-1584 16 p.

    Research output: Contribution to journalArticle

  380. Application of electrospray mass spectrometry to the structural determination of glycosylphosphatidylinositol membrane anchors

    Nett, I. R. E., Mehlert, A., Lamont, D. & Ferguson, M. A. J. May 2010 In : Glycobiology. 20, 5, p. 576-585 10 p.

    Research output: Contribution to journalArticle

  381. Optimization of the interligand Overhauser effect for fragment linking: Application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase

    Sledz, P., Silvestre, H. L., Hung, A. W., Ciulli, A., Blundell, T. L. & Abell, C. 7 Apr 2010 In : Journal of the American Chemical Society. 132, 13, p. 4544-4545 2 p.

    Research output: Contribution to journalArticle

  382. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

    van Aalten, D. M. F. , Gilbert, I. H. , Fairlamb, A. H. , Ferguson, M. A. J. & 22 others Frearson, J. A., Brand, S., McElroy, S. P., Cleghorn, L. A. T., Smid, O., Stojanovski, L., Price, H. P., Guther, M. L. S., Torrie, L. S., Robinson, D. A., Hallyburton, I., Mpamhanga, C. P., Brannigan, J. A., Wilkinson, A. J., Hodgkinson, M., Hui, R., Qiu, W., Raimi, O. G., Brenk, R., Read, K. D., Smith, D. F. & Wyatt, P. G. 1 Apr 2010 In : Nature. 464, 7289, p. 728-732 7 p.

    Research output: Contribution to journalArticle

  383. Fragment Screening by Surface Plasmon Resonance

    Hopkins Navratilova, I. & Hopkins, A. L. Apr 2010 In : ACS Medicinal Chemistry Letters. 1, 1, p. 44-48 5 p.

    Research output: Contribution to journalArticle

  384. Regulation of plant gene expression by alternative splicing

    Simpson, C. G., Manthri, S., Raczynska, K. D., Kalyna, M., Lewandowska, D., Kusenda, B., Maronova, M., Szweykowska-Kulinska, Z., Jarmolowski, A., Barta, A. & Brown, J. W. S. Apr 2010 In : Biochemical Society Transactions. 38, 2, p. 667-671 5 p.

    Research output: Contribution to journalArticle

  385. Shotgun Proteomics in the discovery of biomarkers of non-alcoholic fatty liver disease: an improved methodology

    Miller, M., Jafferbhoy, H., Ferguson, M. A. J. & Dillon, J. Apr 2010 In : Gut. 59, S1, p. A104-A104 1 p.

    Research output: Contribution to journalSpecial issue

  386. Structure of Trypanosoma brucei glutathione synthetase: domain and loop alterations in the catalytic cycle of a highly conserved enzyme

    Fyfe, P. K., Alphey, M. S. & Hunter, W. N. Apr 2010 In : Molecular and Biochemical Parasitology. 170, 2, p. 93-99 7 p.

    Research output: Contribution to journalArticle

  387. The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist

    Rimland, J., Dunne, A., Hunjan, S. S., Sasse, R., Uings, I., Montanari, D., Caivano, M., Shah, P., Standing, D., Gray, D., Brown, D., Cairns, W., Trump, R., Smith, P. W., Bertheleme, N., D'Alessandro, P., Gul, S., Vimal, M., Smith, D. N. & Watson, S. P. Apr 2010 In : Bioorganic & Medicinal Chemistry Letters. 20, 7, p. 2340-3 4 p.

    Research output: Contribution to journalArticle

  388. Water-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis

    Nicoletti, S., Seifert, K. & Gilbert, I. H. Apr 2010 In : Bioorganic & Medicinal Chemistry. 18, 7, p. 2559-2565 7 p.

    Research output: Contribution to journalArticle

  389. 1-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors

    Micheli, F. , Cavanni, P. , Arban, R. , Benedetti, R. , Bertani, B. , Bettati, M. , Bettelini, L. , Bonanomi, G. , Braggio, S. , Checchia, A. , Davalli, S. , Di Fabio, R. , Fazzolari, E. , Fontana, S. , Marchioro, C. , Minick, D. , Negri, M. , Oliosi, B. , Read, K. D. , Sartori, I. & 6 others Tedesco, G., Tarsi, L., Terreni, S., Visentini, F., Zocchi, A. & Zonzini, L. 25 Mar 2010 In : Journal of Medicinal Chemistry. 53, 6, p. 2534-2551 18 p.

    Research output: Contribution to journalArticle

  390. N-myristoyl transferase inhibitors

    Brand, S., Wyatt, P., Thompson, S., Smith, V., Bayliss, T., Harrison, J., Norcross, N., Cleghorn, L., Gilbert, I. & Brenk, R. 11 Mar 2010 PCT/GB2009/002084

    Research output: Patent

  391. Erratum - A case-control study of cutaneous squamous cell carcinoma among Caucasian organ transplant recipients: The role of antibodies against human papillomavirus and other risk factors

    Casabonne, D., Lally, A., Mitchell, L., Michael, K. M., Waterboer, T., Pawlita, M., Imko-Walczuk, B., Wojnarowska, F., Proby, C., Harwood, C. & Newton, R. 1 Mar 2010 In : International Journal of Cancer. 126, 5, p. 1282 1 p.

    Research output: Contribution to journalArticle

  392. Visualizing biological data: now and in the future

    O'Donoghue, S. I., Gavin, A-C., Gehlenborg, N., Goodsell, D. S., Hériché, J-K., Nielsen, C. B., North, C., Olson, A. J., Procter, J. B., Shattuck, D. W., Walter, T. & Wong, B. 1 Mar 2010 In : Nature Methods. 7, 3 SUPPL., p. S2-S4

    Research output: Contribution to journalArticle

  393. A triclinic crystal form of Escherichia coli 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure

    Kalinowska-Tluscik, J., Miallau, L., Gabrielsen, M., Leonard, G. A., McSweeney, S. M. & Hunter, W. N. Mar 2010 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 66, p. 237-241 5 p.

    Research output: Contribution to journalArticle

  394. Assessing brain free fraction in early drug discovery

    Read, K. D. & Braggio, S. Mar 2010 In : Expert Opinion on Drug Metabolism & Toxicology. 6, 3, p. 337-344 8 p.

    Research output: Contribution to journalScientific review

  395. Visualization of multiple alignments, phylogenies and gene family evolution

    Procter, J. B., Thompson, J., Letunic, I., Creevey, C., Jossinet, F. & Barton, G. J. Mar 2010 In : Nature Methods. 7, 3, p. S16-S25 10 p.

    Research output: Contribution to journalScientific review

  396. Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds

    Dorfmueller, H. C. & van Aalten, D. M. F. 19 Feb 2010 In : FEBS Letters. 584, 4, p. 694-700 7 p.

    Research output: Contribution to journalArticle

  397. The genetic diversity and evolution of field pea (Pisum) studied by high throughput retrotransposon based insertion polymorphism (RBIP) marker analysis

    Jing, R., Vershinin, A., Grzebyta, J., Shaw, P., Smykal, P., Marshall, D., Ambrose, M. J., Ellis, T. H. N. & Flavell, A. J. 15 Feb 2010 In : BMC Evolutionary Biology. 10, p. - 20 p., 44

    Research output: Contribution to journalArticle

  398. Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

    Shanks, E. J., Ong, H. B., Robinson, D. A., Thompson, S., Sienkiewicz, N., Fairlamb, A. H. & Frearson, J. A. 15 Jan 2010 In : Analytical Biochemistry. 396, 2, p. 194-203 10 p.

    Research output: Contribution to journalArticle

  399. Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the Leishmaniases

    Tulloch, L. B., Martini, V. P., Iulek, J., Huggan, J. K., Lee, J. H., Gibson, C. L., Smith, T. K., Suckling, C. J. & Hunter, W. N. 14 Jan 2010 In : Journal of Medicinal Chemistry. 53, 1, p. 221-229 9 p.

    Research output: Contribution to journalArticle

  400. A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology

    Durrant, J. D., Amaro, R. E., Xie, L., Urbaniak, M. D., Ferguson, M. A. J., Haapalainen, A., Chen, Z., Di Guilmi, A. M., Wunder, F., Bourne, P. E. & McCammon, J. A. Jan 2010 In : PLoS Computational Biology. 6, 1, p. - 8 p., e1000648

    Research output: Contribution to journalArticle

  401. Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T-cruzi

    Jones, D. C., Ariza, A., Chow, W-H. A., Oza, S. L. & Fairlamb, A. H. Jan 2010 In : Molecular and Biochemical Parasitology. 169, 1, p. 12-19 8 p.

    Research output: Contribution to journalArticle

  402. Micro-magnetic resonance imaging and embryological analysis of wild-type and pma mutant mice with clubfoot

    Duce, S., Madrigal, L., Schmidt, K., Cunningham, C., Liu, G., Barker, S., Tennant, G., Tickle, C., Chudek, S. & Miedzybrodzka, Z. Jan 2010 In : Journal of Anatomy. 216, 1, p. 108-120 13 p.

    Research output: Contribution to journalArticle

  403. Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects

    Price, H. P., Guther, M. L. S., Ferguson, M. A. J. & Smith, D. F. Jan 2010 In : Molecular and Biochemical Parasitology. 169, 1, p. 55-58 4 p.

    Research output: Contribution to journalArticle

  404. The tetrahydrobiopterin pathway and pain

    Naylor, A. M., Pojasek, K. R., Hopkins, A. L. & Blagg, J. Jan 2010 In : Current Opinion in Investigational Drugs. 11, 1, p. 19-30 12 p.

    Research output: Contribution to journalScientific review

  405. An ontology for description of drug discovery investigations

    Qi, D., King, R. D., Hopkins, A. L., Bickerton, G. R. J. & Soldatova, L. N. 2010 In : Journal of Integrative Bioinformatics. 7, 3, 13 p., 126

    Research output: Contribution to journalArticle

  406. Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds

    Ruda, G. F., Wong, P. E., Alibu, V. P., Norval, S., Read, K. D., Barrett, M. P. & Gilbert, I. H. 2010 In : Journal of Medicinal Chemistry. 53, 16, p. 6071-6078 8 p.

    Research output: Contribution to journalArticle

  407. Chemical synthesis of parasitic glycoconjugates and phosphoglycans

    Al-Maharik, N., Tee, J. A. & Nikolaev, A. V. 2010 Microbial glycobiology: structures, relevance and applications. Moran, A. P., Holst, O., Brennan, P. J. & von Itzstein, M. (eds.). London: Academic Press, p. 477-548 72 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  408. On the synthesis of N-maleoyl amino acids in aqueous media: cautionary tales for the unwary traveller

    Paterson, M. J. & Jovanovic, A. 2010 In : ARKIVOC. p. 11-16 6 p.

    Research output: Contribution to journalArticle

  409. The Scottish Structural Proteomics Facility: targets, methods and outputs

    Oke, M. , Carter, L. G. , Johnson, K. A. , Liu, H. , McMahon, S. A. , Yan, X. , Kerou, M. , Weikart, N. D. , Kadi, N. , Sheikh, M. A. , Schmelz, S. , Dorward, M. , Zawadzki, M. , Cozens, C. , Falconer, H. , Powers, H. , Overton, I. M. , van Niekerk, C. A. J. , Peng, X. , Patel, P. & 11 others Garrett, R. A., Prangishvili, D., Botting, C. H., Coote, P. J., Dryden, D. T. F., Barton, G. J., Schwarz-Linek, U., Challis, G. L., Taylor, G. L., White, M. F. & Naismith, J. H. 2010 In : Journal of Structural and Functional Genomics. 11, 2, p. 167-80 14 p.

    Research output: Contribution to journalArticle

  410. Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase

    Ruda, G. F., Campbell, G., Alibu, V. P., Barrett, M. P., Brenk, R. & Gilbert, I. H. 2010 In : Bioorganic & Medicinal Chemistry. 18, 14, p. 5056-5062 7 p.

    Research output: Contribution to journalArticle

  411. Chemical Validation of Trypanothione Synthetase a potential drug targer for human trypanosomiasis

    Torrie, L. S., Wyllie, S., Spinks, D., Oza, S. L., Thompson, S., Harrison, J. R., Gilbert, I. H., Wyatt, P. G., Fairlamb, A. H. & Frearson, J. A. 25 Dec 2009 In : Journal of Biological Chemistry. 284, 52, p. 36137-36145 9 p.

    Research output: Contribution to journalArticle

  412. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

    Zeqiraj, E., Filippi, B. M., Deak, M., Alessi, D. R. & van Aalten, D. M. F. 18 Dec 2009 In : Science. 326, 5960, p. 1707-1711 5 p.

    Research output: Contribution to journalArticle

  413. Thiolactomycin analogues as potential anti-Toxoplasma gondii agents

    Martins-Duarte, E. S., de Souza, W., Vommaro, R. C., Jones, S. M., Gilbert, I. H. & Atella, G. C. 1 Dec 2009 In : Parasitology International. 58, 4, p. 411-415 5 p.

    Research output: Contribution to journalArticle

  414. Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs

    Cole, C., Sobala, A., Lu, C., Thatcher, S. R., Bowman, A., Brown, J. W. S., Green, P. J., Barton, G. J. & Hutvagner, G. Dec 2009 In : RNA: a Publication of the RNA Society. 15, 12, p. 2147-2160 14 p.

    Research output: Contribution to journalArticle

  415. HTS and hit finding in academia - from chemical genomics to drug discovery

    Frearson, J. A. & Collie, I. T. Dec 2009 In : Drug Discovery Today. 14, 23-24, p. 1150-1158 9 p.

    Research output: Contribution to journalArticle

  416. Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

    Spinks, D., Shanks, E. J., Cleghorn, L. A. T., McElroy, S., Jones, D., James, D., Fairlamb, A. H., Frearson, J. A., Wyatt, P. G. & Gilbert, I. H. Dec 2009 In : ChemMedChem. 4, 12, p. 2060-2069 10 p.

    Research output: Contribution to journalArticle

  417. A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry

    Scott, D. E., Dawes, G. J., Ando, M., Abell, C. & Ciulli, A. 23 Nov 2009 In : ChemBioChem. 10, 17, p. 2772-2779 8 p.

    Research output: Contribution to journalArticle

  418. Drug discovery Predicting promiscuity

    Hopkins, A. L. 12 Nov 2009 In : Nature. 462, 7270, p. 167-168 2 p.

    Research output: Contribution to journalEditorial

  419. A requirement for GDP-L-fucose in Leishmania inferred by rescue of D-arabinopyranose/L-fucose salvage mutants (Fkp40(-)/Afkp80(-)) by expression of GDP-L-fuc synthetic enzymes

    Guo, H., Novozhilova, N. M., Bandini, G., Notton, T., Turco, S. J., Ferguson, M. A. J. & Beverley, S. M. Nov 2009 In : Glycobiology. 19, 11, p. 1297-1297 1 p.

    Research output: Contribution to journalMeeting abstract

  420. Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods

    Wyllie, S., Oza, S. L., Patterson, S., Spinks, D., Thompson, S. & Fairlamb, A. H. Nov 2009 In : Molecular Microbiology. 74, 3, p. 529-540 12 p.

    Research output: Contribution to journalArticle

  421. Preferential Activation of TLR2/6 Heterodimer by Synthetic Trypanosoma Cruzi Trypomastigote Glycosylphosphatidylinositols is Enhanced by Coexpression of CD14 and CD36

    Nohara, L., Yashunsky, D., Ferguson, M., Nikolaev, A. & Almeida, I. Nov 2009 In : Glycobiology. 19, 11, p. 1361-1361 1 p., 247

    Research output: Contribution to journalMeeting abstract

  422. Proteomic scale high-sensitivity analyses of GPI membrane anchors

    Mehlert, A. & Ferguson, M. A. J. Nov 2009 In : Glycoconjugate Journal. 26, 8, p. 915-921 7 p.

    Research output: Contribution to journalArticle

  423. Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase

    Hung, A. W., Silvestre, H. L., Wen, S., Ciulli, A., Blundell, T. L. & Abell, C. 26 Oct 2009 In : Angewandte Chemie International Edition. 48, 45, p. 8452-8456 5 p.

    Research output: Contribution to journalArticle

  424. 1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein

    Kelleher, M. O., McMahon, M., Eggleston, I. M., Dixon, M. J., Taguchi, K., Yamamoto, M. & Hayes, J. D. Oct 2009 In : Carcinogenesis. 30, 10, p. 1754-1762 9 p.

    Research output: Contribution to journalArticle

  425. The Orientation of a Tandem POTRA Domain Pair, of the Beta-Barrel Assembly Protein BamA, Determined by PELDOR Spectroscopy

    Ward, R., Zoltner, M., Beer, L., El Mkami, H., Henderson, I. R., Palmer, T. & Norman, D. G. 9 Sep 2009 In : Structure. 17, 9, p. 1187-1194 8 p.

    Research output: Contribution to journalArticle

  426. ABC50 promotes translation initiation in mammalian cells

    Paytubi, S., Wang, X., Lam, Y. W., Izquierdo, L., Hunter, M. J., Jan, E., Hundal, H. S. & Proud, C. G. 4 Sep 2009 In : Journal of Biological Chemistry. 284, 36, p. 24061-24073 13 p.

    Research output: Contribution to journalArticle

  427. Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases

    Izquierdo, L., Schulz, B. L., Rodrigues, J. A., Guther, M. L. S., Procter, J. B., Barton, G. J., Aebi, M. & Ferguson, M. A. J. 2 Sep 2009 In : EMBO Journal. 28, 17, p. 2650-2661 12 p.

    Research output: Contribution to journalArticle

  428. Fate of Glycosylphosphatidylinositol (GPI)-Less Procyclin and Characterization of Sialylated Non-GPI-Anchored Surface Coat Molecules of Procyclic-Form Trypanosoma brucei

    Guether, M. L. S., Beattie, K., Lamont, D. J., James, J., Prescott, A. R. & Ferguson, M. A. J. Sep 2009 In : Eukaryotic Cell. 8, 9, p. 1407-1417 11 p.

    Research output: Contribution to journalArticle

  429. Human miRNA Precursors with Box H/ACA snoRNA Features

    Scott, M. S., Avolio, F., Ono, M., Lamond, A. I. & Barton, G. J. Sep 2009 In : PLoS Computational Biology. 5, 9, p. - 13 p., e1000507

    Research output: Contribution to journalArticle

  430. The emerging academic drug-discovery sector

    Wyatt, P. G. Sep 2009 In : Future Medicinal Chemistry. 1, 6, p. 1013-1017 5 p.

    Research output: Contribution to journalEditorial

  431. The ethanolamine branch of the Kennedy pathway is essential in the bloodstream form of Trypanosoma brucei

    Gibellini, F., Hunter, W. N. & Smith, T. K. Sep 2009 In : Molecular Microbiology. 73, 5, p. 826-843 18 p.

    Research output: Contribution to journalArticle

  432. CARB 22-GPI anchors: WHY and HOW the complex molecules are being synthesized

    Nikolaev, A. V. 16 Aug 2009 In : Abstracts of Papers of the American Chemical Society. 238, p. - 1 p.

    Research output: Contribution to journalBook/Film/Article review

  433. Hit to lead and lead optimization of novel small molecules for the treatment of human African trypanosomiasis

    Freeman, J. C., Perales, J. B., Woodland, A., Bacchi, C. J., Bowling, T. S., Cleghorn, L., Gamon, C. G., Grimaldi, R., Hauser, D., Mercer, L. T., Nare, B., Nguyen, T. M., Noe, R. A., Rewerts, C. E., Wring, S. A., Wyatt, P. G., Yarlett, N. R., Jacobs, R. T. & Don, R. 16 Aug 2009 In : Abstracts of Papers of the American Chemical Society. 238, p. - 1 p.

    Research output: Contribution to journalBook/Film/Article review

  434. SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents

    Gigante, F., Kaiser, M., Brun, R. & Gilbert, I. H. 15 Aug 2009 In : Bioorganic & Medicinal Chemistry. 17, 16, p. 5950-5961 12 p.

    Research output: Contribution to journalArticle

  435. Casein kinase 1 isoform 2 is essential for bloodstream form Trypanosoma brucei

    Urbaniak, M. D. Aug 2009 In : Molecular and Biochemical Parasitology. 166, 2, p. 183-185 3 p.

    Research output: Contribution to journalArticle

  436. Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis

    Richardson, J. L., Nett, I. R. E., Jones, D. C., Abdille, M. H., Gilbert, I. H. & Fairlamb, A. H. Aug 2009 In : ChemMedChem. 4, 8, p. 1333-1340 8 p.

    Research output: Contribution to journalArticle

  437. Site-specific DNA double-strand breaks greatly increase stable transformation efficiency in Trypanosoma brucei

    Glover, L. & Horn, D. Aug 2009 In : Molecular and Biochemical Parasitology. 166, 2, p. 194-197 4 p.

    Research output: Contribution to journalArticle

  438. Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

    Patterson, S., Jones, D. C., Shanks, E. J., Frearson, J. A., Gilbert, I. H., Wyatt, P. G. & Fairlamb, A. H. Aug 2009 In : ChemMedChem. 4, 8, p. 1341-1353 13 p.

    Research output: Contribution to journalArticle

  439. What has DNA sequencing revealed about the VSG expression sites of African trypanosomes?

    McCulloch, R. & Horn, D. Aug 2009 In : Trends in Parasitology. 25, 8, p. 359-363 5 p.

    Research output: Contribution to journalScientific review

  440. One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

    Mpamhanga, C. P., Spinks, D., Tulloch, L. B., Shanks, E. J., Robinson, D. A., Collie, I. T., Fairlamb, A. H., Wyatt, P. G., Frearson, J. A., Hunter, W. N., Gilbert, I. H. & Brenk, R. 23 Jul 2009 In : Journal of Medicinal Chemistry. 52, 14, p. 4454-4465 12 p.

    Research output: Contribution to journalArticle

  441. Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

    Munoz, I. M., Hain, K., Declais, A-C., Gardiner, M., Toh, G. W., Sanchez-Pulido, L., Heuckmann, J. M., Toth, R., Macartney, T., Eppink, B., Kanaar, R., Ponting, C. P., Lilley, D. M. J. & Rouse, J. 10 Jul 2009 In : Molecular Cell. 35, 1, p. 116-127 12 p.

    Research output: Contribution to journalArticle

  442. A crowdsourcing evaluation of the NIH chemical probes

    Oprea, T. I., Bologa, C. G., Boyer, S., Curpan, R. F., Glen, R. C., Hopkins, A. L., Lipinski, C. A., Marshall, G. R., Martin, Y. C., Ostopovici-Halip, L., Rishton, G., Ursu, O., Vaz, R. J., Waller, C., Waldmann, H. & Sklar, L. A. Jul 2009 In : Nature Chemical Biology. 5, 7, p. 441-447 7 p.

    Research output: Contribution to journalArticle

  443. The phosphoproteome of bloodstream form Trypanosoma brucei, causative agent of African sleeping sickness

    Nett, I. R. E., Martin, D. M. A., Miranda-Saavedra, D., Lamont, D., Barber, J. D., Mehlert, A. & Ferguson, M. A. J. Jul 2009 In : Molecular & Cellular Proteomics. 8, 7, p. 1527-1538 12 p.

    Research output: Contribution to journalArticle

  444. The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat

    Large, C. H., Kalinichev, M., Lucas, A., Carignani, C., Bradford, A., Garbati, N., Sartori, I., Austin, N. E., Ruffo, A., Jones, D. N. C., Alvaro, G. & Read, K. D. Jul 2009 In : Epilepsy Research. 85, 1, p. 96-106 11 p.

    Research output: Contribution to journalArticle

  445. Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity

    Holloway, G. A., Charman, W. N., Fairlamb, A. H., Brun, R., Kaiser, M., Kostewicz, E., Novello, P. M., Parisot, J. P., Richardson, J., Street, I. P., Watson, K. G. & Baell, J. B. Jul 2009 In : Antimicrobial Agents and Chemotherapy. 53, 7, p. 2824-2833 10 p.

    Research output: Contribution to journalArticle

  446. Antigenic variation: extending the reach of telomeric silencing

    Horn, D. 23 Jun 2009 In : Current Biology. 19, 12, p. R496-R498 3 p.

    Research output: Contribution to journalEditorial

  447. Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

    Higgins, L. G., Kelleher, M. O., Eggleston, I. M., Itoh, K., Yamamoto, M. & Hayes, J. D. 15 Jun 2009 In : Toxicology and Applied Pharmacology. 237, 3, p. 267-280 14 p.

    Research output: Contribution to journalArticle

  448. GIcNAcstatins are nanomolar inhibitors of human O-GIcNAcase inducing cellular hyper-O-GIcNAcylation

    Dorfmueller, H. C., Borodkin, V. S., Schimpl, M. & van Aalten, D. M. F. 1 Jun 2009 In : Biochemical Journal. 420, p. 221-227 7 p.

    Research output: Contribution to journalArticle

  449. ATP and MO25 alpha regulate the conformational state of the STRAD alpha pseudokinase and activation of the LKB1 tumour suppressor

    Zeqiraj, E., Filippi, B. M., Goldie, S., Navratilova, I., Boudeau, J., Deak, M., Alessi, D. R. & van Aalten, D. M. F. Jun 2009 In : PLoS Biology. 7, 6, p. - 19 p., e1000126

    Research output: Contribution to journalArticle

  450. Structural and functional characterization of a putative polysaccharide deacetylase of the human parasite Encephalitozoon cuniculi

    Urch, J. E., Hurtado-Guerrero, R., Brosson, D., Liu, Z., Eijsink, V. G. H., Texier, C. & van Aalten, D. M. F. Jun 2009 In : Protein Science. 18, 6, p. 1197-1209 13 p.

    Research output: Contribution to journalArticle

  451. System-wide changes to SUMO modifications in response to heat shock

    Golebiowski, F., Matic, I., Tatham, M. H., Cole, C., Yin, Y., Nakamura, A., Cox, J., Barton, G. J., Mann, M. & Hay, R. T. 26 May 2009 In : Science Signaling. 2, 72, 12 p., ra24

    Research output: Contribution to journalArticle

  452. Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb

    Schmidt, K., Hughes, C., Chudek, J. A., Goodyear, S. R., Aspden, R. M., Talbot, R., Gundersen, T. E., Blomhoff, R., Henderson, C., Wolf, C. R. & Tickle, C. 15 May 2009 In : Molecular and Cellular Biology. 29, 10, p. 2716-2729 14 p.

    Research output: Contribution to journalArticle

  453. Jalview Version 2-a multiple sequence alignment editor and analysis workbench

    Waterhouse, A. M., Procter, J. B., Martin, D. M. A., Clamp, M. & Barton, G. J. 1 May 2009 In : BMC Bioinformatics. 25, 9, p. 1189-1191 3 p.

    Research output: Contribution to journalArticle

  454. Structure-based ligand design and the promise held for antiprotozoan drug discovery

    Hunter, W. N. 1 May 2009 In : Journal of Biological Chemistry. 284, 18, p. 11749-11753 5 p.

    Research output: Contribution to journalScientific review

  455. Geobacillus stearothermophilus 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate

    Cameron, S., Martini, V. P., Iulek, J. & Hunter, W. N. May 2009 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 65, p. 450-454 5 p.

    Research output: Contribution to journalArticle

  456. N-(2-hydroxypropyl)methacrylamide-amphotericin B (HPMA-AmB) copolymer conjugates as antileishmanial agents

    Nicoletti, S., Seifert, K. & Gilbert, I. H. May 2009 In : International Journal of Antimicrobial Agents. 33, 5, p. 441-448 8 p.

    Research output: Contribution to journalArticle

  457. A Structure-Based Approach to Ligand Discovery for 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase: A Target for Antimicrobial Therapy

    Ramsden, N. L., Buetow, L., Dawson, A., Kemp, L. A., Ulaganathan, V., Brenk, R., Klebe, G. & Hunter, W. N. 23 Apr 2009 In : Journal of Medicinal Chemistry. 52, 8, p. 2531-2542 12 p.

    Research output: Contribution to journalArticle

  458. GPIomics: global analysis of glycosylphosphatidylinositol-anchored molecules of Trypanosoma cruzi

    Nakayasu, E. S., Yashunsky, D. V., Nohara, L. L., Torrecilhas, A. C. T., Nikolaev, A. V. & Almeida, I. C. Apr 2009 In : Molecular Systems Biology. 5, 17 p., 261

    Research output: Contribution to journalArticle

  459. Identification and specific localization of tyrosine-phosphorylated proteins in Trypanosoma brucei

    Nett, I. R. E., Davidson, L., Lamont, D. & Ferguson, M. A. J. Apr 2009 In : Eukaryotic Cell. 8, 4, p. 617-626 10 p.

    Research output: Contribution to journalArticle

  460. Receptor occupancy and brain free fraction

    Watson, J., Wright, S., Lucas, A., Clarke, K. L., Viggers, J., Cheetham, S., Jeffrey, P., Porter, R. & Read, K. D. Apr 2009 In : Drug Metabolism and Disposition. 37, 4, p. 753-760 8 p.

    Research output: Contribution to journalArticle

  461. Development of a Novel Virtual Screening Cascade Protocol to Identify Potential Trypanothione Reductase Inhibitors

    Perez-Pineiro, R., Burgos, A., Jones, D. C., Andrew, L. C., Rodriguez, H., Suarez, M., Fairlamb, A. H. & Wishart, D. S. 26 Mar 2009 In : Journal of Medicinal Chemistry. 52, 6, p. 1670-1680 11 p.

    Research output: Contribution to journalArticle

  462. Targeted delivery of compounds to Trypanosoma brucei using the melamine motif

    Chollet, C., Baliani, A., Wong, P. E., Barrett, M. P. & Gilbert, I. H. 15 Mar 2009 In : Bioorganic & Medicinal Chemistry. 17, 6, p. 2512-2523 12 p.

    Research output: Contribution to journalArticle

  463. Biochemistry: The evolution of ribozyme chemistry

    Wilson, T. J. & Lilley, D. M. J. 13 Mar 2009 In : Science. 323, 5920, p. 1436-1438 3 p.

    Research output: Contribution to journalArticle

  464. Trypanosoma brucei UDP-glucose:glycoprotein glucosyltransferase has unusual substrate specificity and protects the parasite from stress

    Izquierdo, L., Atrih, A., Rodrigues, J. A., Jones, D. C. & Ferguson, M. A. J. Feb 2009 In : Eukaryotic Cell. 8, 2, p. 230-240 11 p.

    Research output: Contribution to journalArticle

  465. Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase

    McCarthy, O., Musso-Buendia, A., Kaiser, M., Brun, R., Ruiz-Perez, L. M., Johansson, N. G., Pacanowska, D. G. & Gilbert, I. H. Feb 2009 In : European Journal of Medicinal Chemistry. 44, 2, p. 678-688 11 p.

    Research output: Contribution to journalArticle

  466. Nucleosomes can invade DNA territories occupied by their neighbors

    Engeholm, M., de Jager, M., Flaus, A., Brenk, R., van Noort, J. & Owen-Hughes, T. Feb 2009 In : Nature Structural & Molecular Biology. 16, 2, p. 151-158 8 p.

    Research output: Contribution to journalArticle

  467. The Glycogen-Binding Domain on the AMPK β Subunit Allows the Kinase to Act as a Glycogen Sensor

    McBride, A., Ghilagaber, S., Nikolaev, A. & Hardie, D. G. 7 Jan 2009 In : Cell Metabolism. 9, 1, p. 23-34 12 p.

    Research output: Contribution to journalArticle

  468. In vivo imaging of mammalian cells: cell engineering and viability

    Swedlow, J. R., Andrews, P. D. & Platani, M. 1 Jan 2009 In : Cold Spring Harbor Protocols. 4, 9

    Research output: Contribution to journalArticle

  469. In vivo imaging of mammalian cells: image acquisition and analysis

    Swedlow, J. R., Andrews, P. D. & Platani, M. 1 Jan 2009 In : Cold Spring Harbor Protocols. 4, 9

    Research output: Contribution to journalArticle

  470. Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni

    Musso-Buendía, J. A., Vidal, A. E., Carrero-Lérida, J., Ruiz-Pérez, L. M., González-Pacanowska, D., Kasinthan, G., Nguyen, C., Gilbert, I. H., Johansson, N. G. & Wilson, K. 1 Jan 2009 In : Journal of Enzyme Inhibition and Medicinal Chemistry. 24, 1, p. 111-116 6 p.

    Research output: Contribution to journalArticle

  471. A comparative study of methylglyoxal metabolism in trypanosomatids

    Greig, N., Wyllie, S., Patterson, S. & Fairlamb, A. H. Jan 2009 In : FEBS Journal. 276, 2, p. 376-386 11 p.

    Research output: Contribution to journalArticle

  472. Identification of a glycosylphosphatidylinositol anchor-modifying beta 1-3 N-acetylglucosaminyl transferase in Trypanosoma brucei

    Izquierdo, L., Nakanishi, M., Mehlert, A., Machray, G., Barton, G. J. & Ferguson, M. A. J. Jan 2009 In : Molecular Microbiology. 71, 2, p. 478-491 14 p.

    Research output: Contribution to journalArticle

  473. PIPs: human protein-protein interaction prediction database

    McDowall, M. D., Scott, M. S. & Barton, G. J. Jan 2009 In : Nucleic Acids Research. 37, Suppl 1, p. D651-D656 6 p.

    Research output: Contribution to journalArticle

  474. Streptococcus mutans SMU.623c codes for a functional, metal-dependent polysaccharide deacetylase that modulates interactions with salivary agglutinin

    Deng, D. M., Urch, J. E., ten Cate, J. M., Rao, V. A., van Aalten, D. M. F. & Crielaard, W. Jan 2009 In : Journal of Bacteriology. 191, 1, p. 394-402 9 p.

    Research output: Contribution to journalArticle

  475. Diversity oriented syntheses of fused pyrimidines designed as potential antifolates

    Gibson, C. L., Huggan, J. K., Kennedy, A., Kiefer, L., Lee, J. H., Suckling, C. J., Clements, C., Harvey, A. L., Hunter, W. N. & Tulloch, L. B. 2009 In : Organic and Biomolecular Chemistry. 7, 9, p. 1829-1842 14 p.

    Research output: Contribution to journalArticle

  476. DNA breaks as triggers for antigenic variation in African trypanosomes

    Alsford, S., Horn, D. & Glover, L. 2009 In : Genome Biology. 10, 6, 4 p., ARTN 223

    Research output: Contribution to journalScientific review

  477. Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity

    Howard, S. , Berdini, V. , Boulstridge, J. A. , Carr, M. G. , Cross, D. M. , Curry, J. , Devine, L. A. , Early, T. R. , Fazal, L. , Gill, A. L. , Heathcote, M. , Maman, S. , Matthews, J. E. , McMenamin, R. L. , Navarro, E. F. , O'Brien, M. A. , O'Reilly, M. , Rees, D. C. , Reule, M. , Tisi, D. & 3 others Williams, G., Vinković, M. & Wyatt, P. G. 2009 In : Journal of Medicinal Chemistry. 52, 2, p. 379-88 10 p.

    Research output: Contribution to journalArticle

  478. Fragment-based drug discovery in academia: Experiences from a tuberculosis programme

    Heikkila, T. J., Surade, S., Silvestre, H. L., Dias, M. V. B., Ciulli, A., Bromfield, K., Scott, D., Howard, N., Wen, S., Wei, A. H., Osborne, D., Abell, C. & Blundell, T. L. 2009 From Molecules to Medicines: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism. Sussman, J. L. & Spadon, P. (eds.). Springer Netherlands, p. 21-36 16 p. (NATO Science for Peace and Security Series A: Chemistry and Biology)

    Research output: Chapter in Book/Report/Conference proceedingChapter

  479. Glycosylphosphatidylinositol anchors

    Ferguson, M. A. J., Kinoshita, T. & Hart, G. W. 2009 Essentials of glycobiology. Varki, A. (ed.). 2nd ed. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, p. 143-162 20 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  480. How does human O-Glcnacase recognize O-Glcnacylated protein substrates?

    Schimpl, M., Borodkin, V. S. & Van Aalten, D. M. F. 2009 In : Glycobiology. 19, 11, p. 1369-1369 1 p., 272

    Research output: Contribution to journalMeeting abstract

  481. Identification of nucleolar associated chromatin loci reveals clues for nuclear architecture

    van Koningsbruggen, S., Martin, D. M. A., Ariyurek, Y., den Dunnen, J. T. & Lamond, A. I. 2009 In : Cellular Oncology. 31, 2, p. 105-106 2 p., O16

    Research output: Contribution to journalBook/Film/Article review

  482. Kinomer v. 1.0: a database of systematically classified eukaryotic protein kinases

    Martin, D. M. A., Miranda-Saavedra, D. & Barton, G. J. 2009 In : Nucleic Acids Research. 37, Suppl. 1. Database issue, p. D244-D250 7 p.

    Research output: Contribution to journalArticle

  483. Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites

    Baliani, A., Peal, V., Gros, L., Brun, R., Kaiser, M., Barrett, M. P. & Gilbert, I. H. 2009 In : Organic and Biomolecular Chemistry. 7, 6, p. 1154-1166 13 p.

    Research output: Contribution to journalArticle

  484. Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold

    Dixon, M. J., Nathubhai, A., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M. 2009 In : Organic and Biomolecular Chemistry. 7, 2, p. 259-268 10 p.

    Research output: Contribution to journalArticle

  485. Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide

    Fyfe, P. K., Rao, V. A., Zemla, A., Cameron, S. & Hunter, W. N. 2009 In : Angewandte Chemie International Edition. 48, 48, p. 9176-9179 4 p.

    Research output: Contribution to journalArticle

  486. SPPS of the natural product chitinase inhibitor argifin: library generation and biological evaluation

    Dixon, M. J., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M. 2009 Peptides for youth: the proceedings of the 20th American Peptide Symposium. Del Valle, S., Escher, E. & Lubell, W. D. (eds.). New York: Springer , p. 143-144 2 p. (Advances in experimental medicine and biology; vol. 611)

    Research output: Chapter in Book/Report/Conference proceedingChapter

  487. Synthesis and structure-based dissection of cyclic peptide chitinase inhibitors: new leads for antifungal and anti-inflammatory drugs

    Dixon, M. J., Nathubhai, A., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M. 2009 Peptides for youth: the proceedings of the 20th American Peptide Symposium. Del Valle, S., Escher, E. & Lubell, W. D. (eds.). New York: Springer , p. 525-526 2 p. (Advances in experimental medicine and biology; vol. 611)

    Research output: Chapter in Book/Report/Conference proceedingChapter

  488. The GlcNAc-PI de-N-acetylase: structure, function, and activity

    Urbaniak, M. D. & Ferguson, M. A. J. 2009 In : Enzymes. 26, p. 49-64 16 p.

    Research output: Contribution to journalArticle

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