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  1. TbGT8 is a bifunctional glycosyltransferase that elaborates N-linked glycans on a protein phosphatase AcP115 and a GPI-anchor modifying glycan in Trypanosoma brucei

    Nakanishi, M., Karasudani, M., Shiraishi, T., Hashida, K., Hino, M., Ferguson, M. A. J. & Nomoto, H. Jun 2014 In : Parasitology International. 63, 3, p. 513-518 6 p.

    Research output: Contribution to journalArticle

  2. Improved annotation of 3' untranslated regions and complex loci by combination of strand-specific direct RNA sequencing, RNA-seq and ESTs

    Schurch, N. J., Cole, C., Sherstnev, A., Song, J., Duc, C., Storey, K. G., McLean, W. H. I., Brown, S. J., Simpson, G. G. & Barton, G. J. 10 Apr 2014 In : PLoS ONE. 9, 4, e94270

    Research output: Contribution to journalArticle

  3. Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase

    Urbaniak, M. D., Capes, A. S., Crossman, A., O'Neill, S., Thompson, S., Gilbert, I. H. & Ferguson, M. A. J. 31 Mar 2014 In : Carbohydrate Research. 387, p. 54-58 5 p.

    Research output: Contribution to journalArticle

  4. Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues

    Capes, A. S., Crossman, A., Urbaniak, M. D., Gilbert, S. H., Ferguson, M. A. J. & Gilbert, I. H. Mar 2014 In : Organic and Biomolecular Chemistry. 12, 12, p. 1919-1934 16 p.

    Research output: Contribution to journalArticle

  5. Norspermidine is not a self-produced trigger for biofilm disassembly

    Hobley, L., Kim, S. H., Maezato, Y., Wyllie, S., Fairlamb, A. H., Stanley-Wall, N. R. & Michael, A. J. 13 Feb 2014 In : Cell. 156, 4, p. 844-854 11 p.

    Research output: Contribution to journalArticle

  6. Evolution of the nucleus

    Devos, D. P., Gräf, R. & Field, M. C. 5 Feb 2014 In : Current Opinion in Cell Biology. 28, p. 8-15 8 p.

    Research output: Contribution to journalArticle

  7. Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors

    Borodkin, V. S., Schimpl, M., Gundogdu, M., Rafie, K., Dorfmueller, H. C., Robinson, D. A. & van Aalten, D. M. F. 1 Feb 2014 In : Biochemical Journal. 457, 3, p. 497-502 6 p.

    Research output: Contribution to journalArticle

  8. The cyclic AMP phosphodiesterase RegA critically regulates encystation in social and pathogenic amoebas

    Du, Q., Schilde, C., Birgersson, E., Chen, Z-H., McElroy, S. & Schaap, P. Feb 2014 In : Cellular Signalling. 26, 2, p. 453-459 7 p.

    Research output: Contribution to journalArticle

  9. Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei

    Mony, B. M., MacGregor, P., Ivens, A., Rojas, F., Cowton, A., Young, J., Horn, D. & Matthews, K. 30 Jan 2014 In : Nature. 505, 7485, p. 681-685 5 p.

    Research output: Contribution to journalLetter

  10. In Vitro and In Vivo studies of trypanocidal activity of dietary isothiocyanates

    Steverding, D., Michaels, S. & Read, K. D. 22 Jan 2014 In : Planta Medica.

    Research output: Contribution to journalLetter

  11. Is NMR fragment screening fine-tuned to assess druggability of protein-protein interactions?

    Dias, D. M., Van Molle, I., Baud, M. G. J., Galdeano, C., Geraldes, C. F. G. C. & Ciulli, A. 9 Jan 2014 In : ACS Medicinal Chemistry Letters. 5, 1, p. 23-28 6 p.

    Research output: Contribution to journalLetter

  12. Crystals on the cover 2014

    Einspahr, H., Weiss, M. S. & Hunter, W. N. Jan 2014 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 70, 1, p. 1 1 p.

    Research output: Contribution to journalEditorial

  13. A novel marker, ARM58, confers antimony resistance to Leishmania spp

    Nuhs, A., Schäfer, C., Zander, D., Trübe, L., Tejera Nevado, P., Schmidt, S., Arevalo, J., Adaui, V., Maes, L., Dujardin, J-C. & Clos, J. 2014 In : International Journal for Parasitology: Drugs and Drug Resistance. 4, 1, p. 37-47 11 p.

    Research output: Contribution to journalArticle

  14. Antiparasitic chemotherapy: from genomes to mechanisms

    Horn, D. & Duraisingh, M. T. 2014 In : Annual Review of Pharmacology and Toxicology. 54, p. 71-94 24 p.

    Research output: Contribution to journalArticle

  15. Structure of a rare non-standard sequence k-turn bound by L7Ae protein

    Huang, L. & Lilley, D. M. J. 2014 In : Nucleic Acids Research.

    Research output: Contribution to journalArticle

  16. Structure-based virtual screening for the identification of RNA-binding ligands

    Daldrop, P. & Brenk, R. 2014 Therapeutic applications of ribozymes and riboswitches: methods and protocols. Lafontaine, D. & Dubé, A. (eds.). Humana Press, p. 127-139 13 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  17. The role of ligand efficiency metrics in drug discovery

    Hopkins, A. L., Keserü, G. M., Leeson, P. D., Rees, D. C. & Reynolds, C. H. 2014 In : Nature Reviews Drug Discovery. 13, 2, p. 105-121 17 p.

    Research output: Contribution to journalArticle

  18. Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control

    Glover, L., Hutchinson, S., Alsford, S., McCulloch, R., Field, M. C. & Horn, D. Dec 2013 In : Cellular Microbiology. 15, 12, p. 1984-1993 10 p.

    Research output: Contribution to journalArticle

  19. Fragment-based hit identification: thinking in 3D

    Morley, A. D., Pugliese, A., Birchall, K., Bower, J., Brennan, P., Brown, N., Chapman, T., Drysdale, M., Gilbert, I. H., Hoelder, S., Jordan, A., Ley, S. V., Merritt, A., Miller, D., Swarbrick, M. E. & Wyatt, P. G. Dec 2013 In : Drug Discovery Today. 18, 23-24, p. 1221-1227 7 p.

    Research output: Contribution to journalArticle

  20. Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens

    Srikannathasan, V., English, G., Bui, N. K., Trunk, K., O'Rourke, P. E. F., Rao, V. A., Vollmer, W., Coulthurst, S. J. & Hunter, W. N. Dec 2013 In : Acta Crystallographica Section D: Biological Crystallography. 69, 12, p. 2468-2482 15 p.

    Research output: Contribution to journalArticle

  21. Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain

    Ferguson, F. M., Fedorov, O., Chaikuad, A., Philpott, M., Muniz, J. R. C., Felletar, I., von Delft, F., Heightman, T., Knapp, S., Abell, C. & Ciulli, A. Dec 2013 In : Journal of Medicinal Chemistry. 56, 24, p. 10183-10187 5 p.

    Research output: Contribution to journalArticle

  22. Two high-resolution structures of the human E3 ubiquitin ligase Siah1

    Rimsa, V., Eadsforth, T. C. & Hunter, W. N. Dec 2013 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 12, p. 1339-1343 5 p.

    Research output: Contribution to journalArticle

  23. Construction of reference chromosome-scale pseudomolecules for potato: integrating the potato genome with genetic and physical maps

    Sharma, S. K. , Bolser, D. , de Boer, J. , Sønderkær, M. , Amoros, W. , Carboni, M. F. , D'Ambrosio, J. M. , de la Cruz, G. , Di Genova, A. , Douches, D. S. , Eguiluz, M. , Guo, X. , Guzman, F. , Hackett, C. A. , Hamilton, J. P. , Li, G. , Li, Y. , Lozano, R. , Maass, A. , Marshall, D. & 25 others Martinez, D., McLean, K., Mejía, N., Milne, L., Munive, S., Nagy, I., Ponce, O., Ramirez, M., Simon, R., Thomson, S. J., Torres, Y., Waugh, R., Zhang, Z., Huang, S., Visser, R. G. F., Bachem, C. W. B., Sagredo, B., Feingold, S. E., Orjeda, G., Veilleux, R. E., Bonierbale, M., Jacobs, J. M. E., Milbourne, D., Martin, D. M. A. & Bryan, G. J. 1 Nov 2013 In : G3 : Genes, Genomes, Genetics. 3, 11, p. 2031-2047 17 p.

    Research output: Contribution to journalArticle

  24. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

    Madhok, V. B. & 33 others Saunders, S. P., Goh, C. S. M., Brown, S. J., Palmer, C. N. A., Porter, R. M., Cole, C., Campbell, L. E., Gierlinski, M., Barton, G. J., Schneider, G., Balmain, A., Prescott, A. R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y-A., Tavendale, R., Mukhopadhyay, S., Turner, S. W., Sullivan, F. M., Relton, C., Burn, J., Meggitt, S., Smith, C. H., Allen, M. A., Barker, J. N. W. N., Reynolds, N. J., Cordell, H. J., Irvine, A. D., McLean, W. H. I., Sandilands, A. & Fallon, P. G. Nov 2013 In : Journal of Allergy and Clinical Immunology. 132, 5, p. 1121-1129 9 p.

    Research output: Contribution to journalArticle

  25. Transcription Termination and Chimeric RNA Formation Controlled by Arabidopsis thaliana FPA

    Duc, C., Sherstnev, A., Cole, C., Barton, G. & Simpson, G. G. 31 Oct 2013 In : PLoS Genetics. 9, 10, e1003867

    Research output: Contribution to journalArticle

  26. Anti-malarial agents

    Gilbert, I., Norcross, N., Baragana, B. & Porzelle, A. 17 Oct 2013 PCT/GB2013/050633

    Research output: Patent

  27. The RNA-binding protein FPA regulates flg22-triggered defense responses and transcription factor activity by alternative polyadenylation

    Lyons, R., Iwase, A., Gänsewig, T., Sherstnev, A., Duc, C., Barton, G. J., Hanada, K., Higuchi-Takeuchi, M., Matsui, M., Sugimoto, K., Kazan, K., Simpson, G. G. & Shirasu, K. 9 Oct 2013 In : Scientific Reports. 3, 10 p.2866

    Research output: Contribution to journalArticle

  28. Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain

    Rao, F. V., Schüttelkopf, A. W., Dorfmueller, H. C., Ferenbach, A. T., Navratilova, I. & van Aalten, D. M. F. 2 Oct 2013 In : Open Biology. 3, 130021

    Research output: Contribution to journalArticle

  29. Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy

    Ong, H. B., Sienkiewicz, N., Wyllie, S., Patterson, S. & Fairlamb, A. H. Oct 2013 In : Molecular Microbiology. 90, 2, p. 443-455 13 p.

    Research output: Contribution to journalArticle

  30. Drug discovery for the treatment of leishmaniasis, African sleeping sickness and Chagas disease

    Avery, V., Buckner, F., Baell, J., Fairlamb, A., Michels, P. A. & Tarleton, R. Oct 2013 In : Future Medicinal Chemistry. 5, 15, p. 1709-1718 10 p.

    Research output: Contribution to journalArticle

  31. The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

    Patterson, S., Wyllie, S., Stojanovski, L., Perry, M. R., Simeons, F. R. C., Norval, S., Osuna-Cabello, M., De Rycker, M., Read, K. D. & Fairlamb, A. H. Oct 2013 In : Antimicrobial Agents and Chemotherapy. 57, 10, p. 4699-4706 8 p.

    Research output: Contribution to journalArticle

  32. A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei

    Urbaniak, M. D., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Navratilova, I. H., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J. 20 Sep 2013 In : ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.

    Research output: Contribution to journalArticle

  33. Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase

    Hampton, S. E., Schipani, A., Bosch-Navarrete, C., Recio, E., Kaiser, M., Kahnberg, P., González-Pacanowska, D., Johansson, N. G. & Gilbert, I. H. 15 Sep 2013 In : Bioorganic & Medicinal Chemistry. 21, 18, p. 5876-5885 10 p.

    Research output: Contribution to journalArticle

  34. Yeast Mnn9 is both a priming glycosyltransferase and an allosteric activator of mannan biosynthesis

    Striebeck, A., Robinson, D. A., Schüttelkopf, A. W. & van Aalten, D. M. F. Sep 2013 In : Open Biology. 3, 9, 130022

    Research output: Contribution to journalArticle

  35. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery

    Silvestre, H. L., Blundell, T. L., Abell, C. & Ciulli, A. 6 Aug 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 32, p. 12984-12989 6 p.

    Research output: Contribution to journalArticle

  36. Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target

    Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Urbaniak, M. D., Ibrahim, A. F. M., Ferguson, M. A. J., Jin, C. & van Aalten, D. M. F. Aug 2013 In : Molecular Microbiology. 89, 3, p. 479-493 15 p.

    Research output: Contribution to journalArticle

  37. Multimeric complexes among Ankyrin-Repeat and SOCS-box Protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 Ubiquitin Ligases

    Thomas, J. C., Matak-Vinkovic, D., Van Molle, I. & Ciulli, A. 25 Jul 2013 In : Biochemistry. 52, 31, p. 5236-5246 11 p.

    Research output: Contribution to journalArticle

  38. Structure of the SCAN domain of human paternally expressed gene 3 protein

    Rimsa, V., Eadsforth, T. C. & Hunter, W. N. 23 Jul 2013 In : PLoS ONE. 8, 7, e69538

    Research output: Contribution to journalArticle

  39. Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.

    De Rycker, M., Hallyburton, I., Thomas, J., Campbell, L., Wyllie, S., Joshi, D., Cameron, S., Gilbert, I. H., Wyatt, P. G., Frearson, J. A., Fairlamb, A. H. & Gray, D. W. Jul 2013 In : Antimicrobial Agents and Chemotherapy. 57, 7, p. 2913-2922 10 p.

    Research output: Contribution to journalArticle

  40. From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules

    Woodland, A., Grimaldi, R., Luksch, T., Cleghorn, L. A. T., Ojo, K. K., Van Voorhis, W. C., Brenk, R., Frearson, J. A., Gilbert, I. H. & Wyatt, P. G. Jul 2013 In : ChemMedChem. 8, 7, p. 1127-1137 11 p.

    Research output: Contribution to journalArticle

  41. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins

    Gabernet-Castello, C., O'Reilly, A. J., Dacks, J. B. & Field, M. C. 15 May 2013 In : Molecular Biology of the Cell. 24, 10, p. 1574-1583 10 p.

    Research output: Contribution to journalArticle

  42. A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle

    Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., Shattock, M. J., Calaghan, S. C. & Fuller, W. 10 May 2013 In : Journal of Biological Chemistry. 288, 19, p. 13808-13820 13 p.

    Research output: Contribution to journalArticle

  43. Global quantitative SILAC phosphoproteomics reveals differential phosphorylation is widespread between the procyclic and bloodstream form lifecycle stages of Trypanosoma brucei

    Urbaniak, M. D., Martin, D. M. A. & Ferguson, M. A. J. 3 May 2013 In : Journal of Proteome Research. 12, 5, p. 2233-2244 12 p.

    Research output: Contribution to journalArticle

  44. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

    Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P. 1 May 2013 In : Biochemical Journal. 451, 3, p. 427-437 11 p.

    Research output: Contribution to journalArticle

  45. De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments

    Urich, R., Wishart, G., Kiczun, M., Richters, A., Tidten-Luksch, N., Rauh, D., Sherborne, B., Wyatt, P. G. & Brenk, R. May 2013 In : ACS Chemical Biology. 8, 5, p. 1044-1052 9 p.

    Research output: Contribution to journalArticle

  46. Evolution of modular intraflagellar transport from a coatomer-like progenitor

    van Dam, T. J. P., Townsend, M. J., Turk, M., Schlessinger, A., Sali, A., Field, M. C. & Huynen, M. A. 23 Apr 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 17, p. 6943-6948 6 p.

    Research output: Contribution to journalArticle

  47. Structure of a complex phosphoglycan epitope from gp72 of Trypanosoma cruzi

    Allen, S., Richardson, J. M., Mehlert, A. & Ferguson, M. A. J. 19 Apr 2013 In : Journal of Biological Chemistry. 288, 16, p. 11093-11105 13 p.

    Research output: Contribution to journalArticle

  48. Improved sperm function / activity

    Barratt, C. & Wyatt, P. 18 Apr 2013 WO2013054111 A1

    Research output: Patent

  49. Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria

    Gargiulo, L., Papaioannou, M., Sica, M., Talini, G., Chaidos, A., Richichi, B., Nikolaev, A. V., Nativi, C., Layton, M., de la Fuente, J., Roberts, I., Luzzatto, L., Notaro, R. & Karadimitris, A. 4 Apr 2013 In : Blood. 121, 14, p. 2753-2761 9 p.

    Research output: Contribution to journalArticle

  50. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

    Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3 Apr 2013 In : EMBO Journal. 32, 7, p. 1008-22 15 p.

    Research output: Contribution to journalArticle

  51. The architecture of EssB, an integral membrane component of the type VII secretion system

    Zoltner, M., Norman, D. G., Fyfe, P. K., El Mkami, H., Palmer, T. & Hunter, W. N. 2 Apr 2013 In : Structure. 21, 4, p. 595-603 9 p.

    Research output: Contribution to journalArticle

  52. Proteomic analysis of clathrin interactions in trypanosomes reveals dynamic evolution of endocytosis

    Adung'a, V. O., Gadelha, C. & Field, M. C. Apr 2013 In : Traffic. 14, 4, p. 440-457 18 p.

    Research output: Contribution to journalScientific review

  53. DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes

    Glover, L., Alsford, S. & Horn, D. Mar 2013 In : PLoS Pathogens. 9, 3, 15 p.ARTN e1003260

    Research output: Contribution to journalArticle

  54. Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story

    Baker, N., de Koning, H. P., Maeser, P. & Horn, D. Mar 2013 In : Trends in Parasitology. 29, 3, p. 110-118 9 p.

    Research output: Contribution to journalScientific review

  55. The functional exchangeability of pk- and k-turns in RNA structure

    Daldrop, P., Masquida, B. & Lilley, D. M. J. Mar 2013 In : RNA Biology. 10, 3, p. 445-452 8 p.

    Research output: Contribution to journalArticle

  56. The importance of the N-terminus of T7 endonuclease I in the interaction with DNA junctions

    Freeman, A. D. J., Déclais, A-C. & Lilley, D. M. J. 23 Jan 2013 In : Journal of Molecular Biology. 425, 2, p. 395-410 16 p.

    Research output: Contribution to journalArticle

  57. Characterization of Staphylococcus aureus EssB, an integral membrane component of the Type VII secretion system: atomic resolution crystal structure of the cytoplasmic segment

    Zoltner, M., Fyfe, P. K., Palmer, T. & Hunter, W. N. 15 Jan 2013 In : Biochemical Journal. 449, 2, p. 469-477 9 p.

    Research output: Contribution to journalArticle

  58. PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway

    Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15 Jan 2013 In : Journal of Immunology. 190, 2, p. 565-77 13 p.

    Research output: Contribution to journalArticle

  59. Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

    Munday, J. C., Eze, A. A., Baker, N., Glover, L., Clucas, C., Aguinaga Andrés, D., Natto, M. J., Teka, I. A., McDonald, J., Lee, R. S., Graf, F. E., Ludin, P., Burchmore, R. J. S., Turner, C. M. R., Tait, A., MacLeod, A., Mäser, P., Barrett, M. P., Horn, D. & De Koning, H. P. 2013 In : Journal of Antimicrobial Chemotherapy.

    Research output: Contribution to journalArticle

  60. A Lack of premature termination codon read-through efficacy of PTC124 (Ataluren) in a diverse array of reporter assays

    McElroy, S. P., Nomura, T., Torrie, L. S., Warbrick, E., Gartner, U., Wood, G. & McLean, W. H. I. 2013 In : PLoS Biology. 11, 6, e1001593

    Research output: Contribution to journalArticle

  61. A mechanistic comparison of the varkud satellite and hairpin ribozymes

    Wilson, T. J. & Lilley, D. M. J. 2013 Catalytic RNA. Soukup, G. A. (ed.). London: Academic Press, p. 93-121 29 p. (Progress in molecular biology and translational science).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  62. A nonsense mutation in the mattrin gene causes the matted mouse phenotype and is a predisposing gene for atopic dermatitis in humans

    Goh, C. S., Saunders, S. P., Cole, C., Weidinger, S., Baurecht, H., Lee, Y., Reynolds, N. J., Barker, J. N., Cordell, H. J., Brown, S. J., Irvine, A. D., McLean, I., Sandilands, A. & Fallon, P. G. 2013 In : Journal of Investigative Dermatology. 133, S1, p. S145 1 p.854

    Research output: Contribution to journalMeeting abstract

  63. A sweet TET-a-tete-synergy of TET proteins and O-GlcNAc transferase in transcription

    Mariappa, D., Pathak, S. & van Aalten, D. M. F. 2013 In : EMBO Journal. 32, 5, p. 612-613 2 p.

    Research output: Contribution to journalEditorial

  64. Biophysical screening for the discovery of small-molecule ligands

    Ciulli, A. 2013 Protein-ligand interactions: methods and applications. Williams, M. A. & Daviter, T. (eds.). Humana Press, p. 357-388 32 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  65. Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis

    Perry, M. R., Wyllie, S., Raab, A., Feldmann, J. & Fairlamb, A. H. 2013 In : Proceedings of the National Academy of Sciences. n/a, n/a

    Research output: Contribution to journalArticle

  66. Creation and characterization of glycosyltransferase mutants of trypanosoma brucei

    Izquierdo, L., Güther, M. L. S. & Ferguson, M. A. J. 2013 Glycosyltransferases. Brockhausen, I. (ed.). Humana Press, p. 249-275 27 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  67. Discovery and structure-activity relationships of pyrrolone antimalarials

    Murugesan, D., Mital, A., Kaiser, M., Shackleford, D. M., Morizzi, J., Katneni, K., Campbell, M., Hudson, A., Charman, S. A., Yeates, C. & Gilbert, I. H. 2013 In : Journal of Medicinal Chemistry. 56, 7, p. 2975-2990 16 p.

    Research output: Contribution to journalArticle

  68. Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa

    Cukier, C. D., Hope, A. G., Elamin, A. A., Moynie, L., Schnell, R., Schach, S., Kneuper, H., Singh, M., Naismith, J. H., Lindqvist, Y., Gray, D. W. & Schneider, G. 2013 In : ACS Chemical Biology. n/a, cb4005063

    Research output: Contribution to journalArticle

  69. Discovery of Β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

    Aristotelous, T., Ahn, S., Shukla, A. K., Gawron, S., Sassano, M. F., Kahsai, A. W., Wingler, L. M., Zhu, X., Tripathi-Shukla, P., Huang, X-P., Riley, J., Besnard, J., Read, K. D., Roth, B. L., Gilbert, I. H., Hopkins, A. L., Lefkowitz, R. J. & Navratilova, I. 2013 In : ACS Medicinal Chemistry Letters. 4, 10, p. 1005-1010 6 p.

    Research output: Contribution to journalArticle

  70. Drug discovery for neglected diseases: molecular target-based and phenotypic approaches

    Gilbert, I. H. 2013 In : Journal of Medicinal Chemistry. 56, 20, p. 7719-7726 8 p.

    Research output: Contribution to journalArticle

  71. Electromechanical Behaviour of Nafion-based Soft Actuators

    Naji, L., Chudek, J. A., Abel, E. W. & Baker, R. T. 2013 In : Journal of Physical Chemistry B. 1, 19, p. 2502-2514 13 p.

    Research output: Contribution to journalArticle

  72. Imaging African trypanosomes

    MacLean, L., Myburgh, E., Rodgers, J. & Price, H. P. 2013 In : Parasite Immunology. 35, 9-10, p. 283-294 12 p.

    Research output: Contribution to journalArticle

  73. Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes

    Narlikar, G. J., Sundaramoorthy, R. & Owen-Hughes, T. 2013 In : Cell. 154, 3, p. 490-503 14 p.

    Research output: Contribution to journalArticle

  74. Mechanistic dichotomy in the asymmetric allylation of aldehydes with allyltrichlorosilanes catalyzed by chiral pyridine N-oxides

    Malkov, A. V., Stončius, S., Bell, M., Castelluzzo, F., Ramírez-López, P., Biedermannová, L., Langer, V., Rulíšek, L. & Kočovský, P. 2013 In : Chemistry: a European Journal. 19, 28, p. 9167-9185 19 p.

    Research output: Contribution to journalArticle

  75. Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry

    Hahne, H., Sobotzki, N., Nyberg, T., Helm, D., Borodkin, V. S., van Aalten, D. M. F., Agnew, B. & Kuster, B. 2013 In : Journal of Proteome Research. 12, 2, p. 927-936 10 p.

    Research output: Contribution to journalArticle

  76. Regulation of the cardiac Na(+) pump by palmitoylation of its catalytic and regulatory subunits

    Howie, J., Tulloch, L. B., Shattock, M. J. & Fuller, W. 2013 In : Biochemical Society Transactions. 41, 1, p. 95-100 6 p.

    Research output: Contribution to journalArticle

  77. Structure of Pseudomonas aeruginosa inosine 5-monophosphate dehydrogenase

    Rao, V. A., Shepherd, S. M., Owen, R. & Hunter, W. N. 2013 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 3, p. 243-247 5 p.

    Research output: Contribution to journalArticle

  78. Structure-Activity Relationship Studies of Pyrrolone Antimalarial Agents

    Murugesan, D., Kaiser, M., White, K. L., Norval, S., Riley, J., Wyatt, P. G., Charman, S. A., Read, K. D., Yeates, C. & Gilbert, I. H. 2013 In : ChemMedChem.

    Research output: Contribution to journalArticle

  79. The architecture of Trypanosoma brucei tubulin-binding cofactor B and implications for function

    Fleming, J. R., Morgan, R. E., Fyfe, P. K., Kelly, S. M. & Hunter, W. N. 2013 In : FEBS Journal. 280, 14, p. 3270-3280 11 p.

    Research output: Contribution to journalArticle

  80. The CD11b-integrin (ITGAM) and systemic lupus erythematosus

    Fagerholm, S. C., Macpherson, M., James, M. J., Sevier-Guy, C. & Lau, C. S. 2013 In : Lupus. 22, 7, p. 657-663 7 p.

    Research output: Contribution to journalArticle

  81. The impact of KLF2 modulation on the transcriptional program and function of CD8 T Cells

    Preston, G. C., Feijoo-Carnero, C., Schurch, N., Cowling, V. H. & Cantrell, D. A. 2013 In : PLoS ONE. 8, 10, 16 p.e77537

    Research output: Contribution to journalArticle

  82. The plasticity of a structural motif in RNA: Structural polymorphism of a kink turn as a function of its environment

    Daldrop, P. & Lilley, D. M. J. 2013 In : RNA: a Publication of the RNA Society. 19, 3, p. 357-364 8 p.

    Research output: Contribution to journalArticle

  83. Automated design of ligands to polypharmacological profiles

    Gilbert, I. H. & 20 others Besnard, J., Ruda, G. F., Setola, V., Abecassis, K., Rodriguiz, R. M., Huang, X-P., Norval, S., Sassano, M. F., Shin, A. I., Webster, L. A., Simeons, F. R. C., Stojanovski, L., Prat, A., Seidah, N. G., Constam, D. B., Bickerton, G. R., Read, K. D., Wetsel, W. C., Roth, B. L. & Hopkins, A. L. 13 Dec 2012 In : Nature. 492, 7428, p. 215-+ 8 p.

    Research output: Contribution to journalArticle

  84. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P-3-dependent mechanisms leading to resistance to PDK1 inhibitors

    Najafov, A., Shpiro, N. & Alessi, D. R. Dec 2012 In : Biochemical Journal. 448, 2, p. 285-295 11 p.

    Research output: Contribution to journalArticle

  85. A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes

    De Rycker, M., O'Neill, S., Joshi, D., Campbell, L., Gray, D. W. & Fairlamb, A. H. 29 Nov 2012 In : PLoS Neglected Tropical Diseases. 6, 11, p. e1932

    Research output: Contribution to journalArticle

  86. Structural plasticity of histones H3–H4 facilitates their allosteric exchange between RbAp48 and ASF1

    Zhang, W., Yyl, M., Ward, R., Sobott, F., Maman, J., Murthy, A., Watson, A., Fedorov, O., Bowman, A., Owen-Hughes, T., El Mkami, H., Murzina, N., Norman, D. G. & Laue, E. 25 Nov 2012 In : Nature Structural & Molecular Biology. 20, 1, p. 29-35

    Research output: Contribution to journalArticle

  87. Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α

    Buckley, D. L., Gustafson, J. L., Van-Molle, I., Roth, A. G., Tae, H. S., Gareiss, P. C., Jorgensen, W. L., Ciulli, A. & Crews, C. M. 12 Nov 2012 In : Angewandte Chemie International Edition. 51, 46, p. 11463-11467 5 p.

    Research output: Contribution to journalArticle

  88. Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei

    Alsford, S. & Horn, D. Nov 2012 In : Nucleic Acids Research. 40, 20, p. 10150-10160 11 p.

    Research output: Contribution to journalArticle

  89. Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma

    Pohler, E. , Mamai, O. , Hirst, J. , Zamiri, M. , Horn, H. , Nomura, T. , Irvine, A. D. , Moran, B. , Wilson, N. J. , Smith, F. J. D. , Goh, C. S. M. , Sandilands, A. , Cole, C. , Barton, G. J. , Evans, A. T. , Shimizu, H. , Akiyama, M. , Suehiro, M. , Konohana, I. , Shboul, M. & 12 others Teissier, S., Boussofara, L., Denguezli, M., Saad, A., Gribaa, M., Dopping-Hepenstal, P. J., McGrath, J. A., Brown, S. J., Goudie, D. R., Reversade, B., Munro, C. S. & McLean, W. H. I. Nov 2012 In : Nature Genetics. 44, 11, p. 1272-1276 5 p.

    Research output: Contribution to journalArticle

  90. New secreted toxins and immunity proteins encoded within the type VI secretion system gene cluster of Serratia marcescens

    English, G., Trunk, K., Rao, V. A., Srikannathasan, V., Hunter, W. N. & Coulthurst, S. J. Nov 2012 In : Molecular Microbiology. 86, 4, p. 921-936 16 p.

    Research output: Contribution to journalArticle

  91. Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems

    Nelson, S. A., Li, Z., Newton, I. P., Fraser, D., Milne, R. E., Martin, D. M. A., Schiffmann, D., Yang, X., Dormann, D., Weijer, C. J., Appleton, P. L. & Nathke, I. S. Nov 2012 In : Disease Models & Mechanisms. 5, 6, p. 940-947 8 p.

    Research output: Contribution to journalArticle

  92. Dissecting fragment-based lead discovery at the von hippel-lindau protein: Hypoxia inducible factor 1α protein-protein interface

    Van Molle, I., Thomann, A., Buckley, D. L., So, E. C., Lang, S., Crews, C. M. & Ciulli, A. 26 Oct 2012 In : Chemistry & Biology. 19, 10, p. 1300-1312 13 p.

    Research output: Contribution to journalArticle

  93. Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

    Jones, D. C., Alphey, M. S., Wyllie, S. & Fairlamb, A. H. Oct 2012 In : Molecular Microbiology. 86, 1, p. 51-64 14 p.

    Research output: Contribution to journalArticle

  94. Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121

    Hudson, S. A., McLean, K. J., Surade, S., Yang, Y-Q., Leys, D., Ciulli, A., Munro, A. W. & Abell, C. 10 Sep 2012 In : Angewandte Chemie International Edition. 51, 37, p. 9311-9316 6 p.

    Research output: Contribution to journalArticle

  95. Direct sequencing of Arabidopsis thaliana RNA reveals patterns of cleavage and polyadenylation

    Sherstnev, A., Duc, C., Cole, C., Zacharaki, V., Hornyik, C., Ozsolak, F., Milos, P. M., Barton, G. J. & Simpson, G. G. Aug 2012 In : Nature Structural & Molecular Biology. 19, 8, p. 845-852 8 p.

    Research output: Contribution to journalArticle

  96. Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

    Baker, N., Glover, L., Munday, J. C., Andres, D. A., Barrett, M. P., de Koning, H. P. & Horn, D. 3 Jul 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 27, p. 10996-11001 6 p.

    Research output: Contribution to journalArticle

  97. Essential Role for IKK beta in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

    Pauls, E., Shpiro, N., Peggie, M., Young, E. R., Sorcek, R. J., Tan, L., Choi, H. G. & Cohen, P. 1 Jun 2012 In : Journal of Biological Chemistry. 287, 23, p. 19216-19228 13 p.

    Research output: Contribution to journalArticle

  98. Pathways analysis in kidney cancer using proteomics approach

    Zakikhani, M., Atrih, A., Lamont, S. R., Goodman, C., Fleming, I. N. & Nabi, G. Jun 2012 In : BJU International. 109, p. 24-24 1 p.

    Research output: Contribution to journalSpecial issue

  99. Structure and folding of a rare, natural kink turn in RNA with an A•A pair at the 2•d2n position

    Schroeder, K. T., Daldrop, P., McPhee, S. A. & Lilley, D. M. J. Jun 2012 In : RNA: a Publication of the RNA Society. 18, 6, p. 1257-1266 10 p.

    Research output: Contribution to journalArticle

  100. Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes

    Alsford, S., duBois, K., Horn, D. & Field, M. C. 29 May 2012 In : Expert reviews in molecular medicine. 14, 20 p.ARTN e13

    Research output: Contribution to journalScientific review

  101. Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation

    Klotz-Noack, K., McIntosh, D., Schurch, N., Pratt, N. & Blow, J. J. 15 May 2012 In : Journal of Cell Science. 125, 10, p. 2436-2445 10 p.

    Research output: Contribution to journalArticle

  102. Combining PET biodistribution and equilibrium dialysis assays to assess the free brain concentration and BBB transport of CNS drugs

    Gunn, R. N., Summerfield, S. G., Salinas, C. A., Read, K. D., Guo, Q., Searle, G. E., Parker, C. A., Jeffrey, P. & Laruelle, M. May 2012 In : Journal of Cerebral Blood Flow and Metabolism. 32, 5, p. 874-883 10 p.

    Research output: Contribution to journalArticle

  103. Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo

    Hack, K., Reilly, L., Palmer, C., Read, K., Norval, S., Kime, R., Booth, K. & Foerster, J. May 2012 In : PLoS ONE. 7, 5

    Research output: Contribution to journalArticle

  104. The lipid-linked oligosaccharide donor specificities of Trypanosoma brucei oligosaccharyltransferases

    Izquierdo, L., Mehlert, A. & Ferguson, M. A. J. May 2012 In : Glycobiology. 22, 5, p. 696-703 8 p.

    Research output: Contribution to journalArticle

  105. Trypanosomal histone γH2A and the DNA damage response

    Glover, L. & Horn, D. May 2012 In : Molecular and Biochemical Parasitology. 183, 1, p. 78-83 6 p.

    Research output: Contribution to journalArticle

  106. Human box C/D snoRNA processing conservation across multiple cell types

    Scott, M. S., Ono, M., Yamada, K., Endo, A., Barton, G. J. & Lamond, A. I. Apr 2012 In : Nucleic Acids Research. 40, 8, p. 3676-3688 13 p.

    Research output: Contribution to journalArticle

  107. Modeling of the N-Glycosylated Transferrin Receptor Suggests How Transferrin Binding Can Occur within the Surface Coat of Trypanosoma brucei

    Mehlert, A., Wormald, M. R. & Ferguson, M. A. J. Apr 2012 In : PLoS Pathogens. 8, 4, p. - 11 p.e1002618

    Research output: Contribution to journalArticle

  108. Regulation of the cardiac sodium pump

    Fuller, W., Tulloch, L. B., Howie, J., Wypijewski, K. J., Shattock, M. J. & Calaghan, S. C. Apr 2012 In : Cellular and Molecular Life Sciences. 70, 8, p. 1357-1380 24 p.

    Research output: Contribution to journalArticle

  109. The de novo and salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-form Trypanosoma brucei

    Kuettel, S., Wadum, M. C. T., Guther, M. L. S., Marino, K., Riemer, C. & Ferguson, M. A. J. Apr 2012 In : Molecular Microbiology. 84, 2, p. 340-351 12 p.

    Research output: Contribution to journalArticle

  110. Transcriptome analysis of skin reveals differences between atopic eczema cases stratified for filaggrin genotype

    Brown, S., Cole, C., Irvine, A., Barton, G. & McLean, I. Apr 2012 In : British Journal of Dermatology. 166, 4, p. e26-e27 2 p.O-30

    Research output: Contribution to journalArticle

  111. A quantitative spatial proteomics analysis of proteome turnover in human cells

    Boisvert, F-M., Ahmad, Y., Gierlinski, M., Charrière, F., Lamont, D., Scott, M., Barton, G. & Lamond, A. I. 1 Mar 2012 In : Molecular & Cellular Proteomics. 11, 3, M111.011429

    Research output: Contribution to journalArticle

  112. Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei

    Kelly, J. M., Taylor, M. C., Horn, D., Loza, E., Kalvinsh, I. & Bjorkling, F. 1 Mar 2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 5, p. 1886-1890 5 p.

    Research output: Contribution to journalArticle

  113. Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness

    Abdelwahab, N. Z., Crossman, A. T., Sullivan, L., Ferguson, M. A. J. & Urbaniak, M. D. Mar 2012 In : Chemical Biology & Drug Design. 79, 3, p. 270-278 9 p.

    Research output: Contribution to journalArticle

  114. Conserved signal peptide recognition systems across the prokaryotic domains

    Coulthurst, S. J., Dawson, A., Hunter, W. N. & Sargent, F. 28 Feb 2012 In : Biochemistry. 51, 8, p. 1678-1686 9 p.

    Research output: Contribution to journalArticle

  115. Synergy of peptide and sugar in O-GlcNAcase substrate recognition

    Schimpl, M., Borodkin, V. S., Gray, L. J. & van Aalten, D. M. F. 24 Feb 2012 In : Chemistry & Biology. 19, 2, p. 173-178 6 p.

    Research output: Contribution to journalArticle

  116. Comparative proteomics profiling of a gentamicin-attenuated Leishmania infantum cell line identifies key changes in parasite thiol-redox metabolism

    Daneshvar, H., Wyllie, S., Phillips, S., Hagan, P. & Burchmore, R. 16 Feb 2012 In : Journal of Proteomics. 75, 5, p. 1463-1471 9 p.

    Research output: Contribution to journalArticle

  117. Quinol derivatives as potential trypanocidal agents

    Capes, A., Patterson, S., Wyllie, S., Hallyburton, I., Collie, I. T., McCarroll, A. J., Stevens, M. F. G., Frearson, J. A., Wyatt, P. G., Fairlamb, A. H. & Gilbert, I. H. 15 Feb 2012 In : Bioorganic & Medicinal Chemistry. 20, 4, p. 1607-1615 9 p.

    Research output: Contribution to journalArticle

  118. High-throughput decoding of antitrypanosomal drug efficacy and resistance

    Alsford, S., Eckert, S., Baker, N., Glover, L., Sanchez-Flores, A., Leung, K. F., Turner, D. J., Field, M. C., Berriman, M. & Horn, D. 9 Feb 2012 In : Nature. 482, 7384, p. 232-236 6 p.

    Research output: Contribution to journalArticle

  119. Infectious disease: Genomics decodes drug action

    Fairlamb, A. H. 9 Feb 2012 In : Nature. 482, 7384, p. 167-169 3 p.

    Research output: Contribution to journalEditorial

  120. Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

    Hjerpe, R., Thomas, Y., Chen, J., Zemla, A., Curran, S., Shpiro, N., Dick, L. R. & Kurz, T. 1 Feb 2012 In : Biochemical Journal. 441, 3, p. 927-936 10 p.

    Research output: Contribution to journalArticle

  121. The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis

    Wyllie, S., Patterson, S., Stojanovski, L., Simeons, F. R. C., Norval, S., Kime, R., Read, K. D. & Fairlamb, A. H. 1 Feb 2012 In : Science Translational Medicine. 4, 119, p. - 7 p.119re1

    Research output: Contribution to journalArticle

  122. Biosensor-Based Approach to the Identification of Protein Kinase Ligands with Dual-Site Modes of Action

    Navratilova, I., Macdonald, G., Robinson, C., Hughes, S., Mathias, J., Phillips, C. & Cook, A. Feb 2012 In : Journal of Biomolecular Screening. 17, 2, p. 183-193 11 p.

    Research output: Contribution to journalArticle

  123. Quantifying the chemical beauty of drugs

    Bickerton, G. R., Paolini, G. V., Besnard, J., Muresan, S. & Hopkins, A. L. Feb 2012 In : Nature Chemistry. 4, 2, p. 90-98 9 p.

    Research output: Contribution to journalArticle

  124. The crystal structure of Leishmania major N-5,N-10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target

    Eadsforth, T. C., Cameron, S. & Hunter, W. N. Feb 2012 In : Molecular and Biochemical Parasitology. 181, 2, p. 178-185 8 p.

    Research output: Contribution to journalArticle

  125. Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

    Brand, S., Cleghorn, L. A. T., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Read, K. D., Wyatt, P. G. & Gilbert, I. H. 12 Jan 2012 In : Journal of Medicinal Chemistry. 55, 1, p. 140-152 13 p.

    Research output: Contribution to journalArticle

  126. Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

    Spinks, D., Torrie, L. S., Thompson, S., Harrison, J. R., Frearson, J. A., Read, K. D., Fairlamb, A. H., Wyatt, P. G. & Gilbert, I. H. 2 Jan 2012 In : ChemMedChem. 7, 1, p. 95-106 12 p.

    Research output: Contribution to journalArticle

  127. A comparative study of the CYP450 inhibition potential of marketed drugs using two fluorescence based assay platforms routinely used in the pharmaceutical industry

    Kajbaf, M., Longhi, R., Montanari, D., Vinco, F., Rigo, M., Fontano, S. & Read, K. D. 2012 In : Drug Metabolism Letters. 5, 1, p. 30-39 10 p.

    Research output: Contribution to journalArticle

  128. Allosteric competitive inhibitors of the glucose-1-phosphate Thymidylyltransferase (RmlA) from  seudomonas aeruginosa

    Alphey, M. S., Pirrie, L., Torrie, L. S., Boulkeroua, W. A., Gardiner, M., Sarkar, A., Maringer, M., Oehlmann, W., Brenk, R., Scherman, M. S., McNeil, M., Rejzek, M., Field, R. A., Singh, M., Gray, D., Westwood, N. J. & Naismith, J. H. 2012 In : ACS Chemical Biology.

    Research output: Contribution to journalArticle

  129. Assessment of pseudomonas aeruginosa N-5,N-10-methylenetetrahydrofolate dehydrogenase - cyclohydrolase as a potential antibacterial drug target

    Eadsforth, T. C., Gardiner, M., Maluf, F. V., McElroy, S., James, D., Frearson, J., Gray, D. & Hunter, W. N. 2012 In : PLoS ONE. 7, 4, p. - 11 p.e35973

    Research output: Contribution to journalArticle

  130. Avirulence protein 3a (AVR3a) from the potato pathogen Phytophthora infestans forms homodimers through its predicted translocation region and does not specifically bind phospholipids

    Wawra, S., Agacan, M., Boddey, J. A., Davidson, I., Gachon, C. M. M., Zanda, M., Grouffaud, S., Whisson, S. C., Birch, P. R. J., Porter, A. J. & Van West, P. 2012 In : Journal of Biological Chemistry. 287, 45, p. 38101-38109 9 p.

    Research output: Contribution to journalArticle

  131. BioJava: an open-source framework for bioinformatics in 2012

    Prlic, A., Yates, A., Bliven, S. E., Rose, P. W., Jacobsen, J., Troshin, P. V., Chapman, M., Gao, J., Koh, C. H., Foisy, S., Holland, R., Rimsa, G., Heuer, M. L., Brandstaetter-Mueller, H., Bourne, P. E. & Willis, S. 2012 In : Bioinformatics. 28, 20, p. 2693-2695 3 p.

    Research output: Contribution to journalArticle

  132. Change or be changed: reflections of the workshop 'Future in Medicinal Chemistry'

    Brenk, R. & Rauh, D. 2012 In : Bioorganic & Medicinal Chemistry. 20, 12, p. 3695-3697 3 p.

    Research output: Contribution to journalArticle

  133. Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei

    Urbaniak, M. D., Mathieson, T., Bantscheff, M., Eberhard, D., Grimaldi, R., Miranda-Saavedra, D., Wyatt, P., Ferguson, M. A. J., Frearson, J. & Drewes, G. 2012 In : ACS Chemical Biology. 7, 11, p. 1858-1865 8 p.

    Research output: Contribution to journalArticle

  134. Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo

    Wishart, T. M., Rooney, T. M., Lamont, D. J., Wright, A. K., Morton, A. J., Jackson, M., Freeman, M. R. & Gillingwater, T. H. 2012 In : PLoS Genetics. 8, 8

    Research output: Contribution to journalArticle

  135. Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages

    Urbaniak, M. D., Guther, M. L. S. & Ferguson, M. A. J. 2012 In : PLoS ONE. 7, 5, p. - 8 p.e36619

    Research output: Contribution to journalArticle

  136. Genetic diversity in European Pisum germplasm collections

    Jing, R., Ambrose, M. A., Knox, M. R., Smykal, P., Hybl, M., Ramos, A., Caminero, C., Burstin, J., Duc, G., van Soest, L. J. M., Swiecicki, W. K., Pereira, M. G., Vishnyakova, M., Davenport, G. F., Flavell, A. J. & Ellis, T. H. N. 2012 In : Theoretical and Applied Genetics. 125, 2, p. 367-380 14 p.

    Research output: Contribution to journalArticle

  137. Guidelines for the use and interpretation of assays for monitoring autophagy

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  138. Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide- binding properties

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    Research output: Contribution to journalArticle

  139. Introduction: the case for polypharmacology

    Hopkins, A. L. 2012 Polypharmacology in drug discovery. Peters, J-U. (ed.). Hoboken: John Wiley & Sons, p. 1-6 6 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  140. IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening

    Tidten-Luksch, N., Grimaldi, R., Torrie, L. S., Frearson, J. A., Hunter, W. N. & Brenk, R. 2012 In : PLoS ONE. 7, 4, p. - 16 p.e35792

    Research output: Contribution to journalArticle

  141. Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation

    Fyfe, P. K., Westrop, G. D., Silva, A. M., Coombs, G. H. & Hunter, W. N. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 29, p. 11693-11698 6 p.

    Research output: Contribution to journalArticle

  142. Live imaging of nascent RNA dynamics reveals distinct types of transcriptional pulse regulation

    Muramoto, T., Cannon, D., Gierlinski, M., Corrigan, A., Barton, G. J. & Chubb, J. R. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 19, p. 7350-7355 6 p.

    Research output: Contribution to journalArticle

  143. MSK1 regulates homeostatic and experience-dependent synaptic plasticity

    Corrêa, S. A. L., Hunter, C. J., Palygin, O., Wauters, S. C., Martin, K. J., McKenzie, C., McKelvey, K., Morris, R. G. M., Pankratov, Y., Arthur, J. S. C. & Frenguelli, B. 2012 In : Journal of Neuroscience. 32, 38, p. 13039-13051 13 p.

    Research output: Contribution to journalArticle

  144. NUP-1 is a large coiled-coil nucleoskeletal protein in Trypanosomes with lamin-like functions

    DuBois, K. N., Alsford, S., Holden, J. M., Buisson, J., Swiderski, M., Bart, J-M., Ratushny, A. V., Wan, Y., Bastin, P., Barry, J. D., Navarro, M., Horn, D., Aitchison, J. D., Rout, M. P. & Field, M. C. 2012 In : PLoS Biology. 10, 3, 20 p.e1001287

    Research output: Contribution to journalArticle

  145. O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

    Schimpl, M., Zheng, X., Borodkin, V. S., Blair, D. E., Ferenbach, A. T., Schüttelkopf, A. W., Navratilova, I., Aristotelous, T., Albarbarawi, O., Robinson, D. A., van Aalten, D. M. F. & Macnaughtan, M. A. 2012 In : Nature Chemical Biology.

    Research output: Contribution to journalArticle

  146. Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase

    Bandini, G., Marino, K., Güther, M. L. S., Wernimont, A. K., Kuettel, S., Qiu, W., Afzal, S., Kelner, A., Hui, R. & Ferguson, M. A. J. 2012 In : Molecular Microbiology. 85, 3, p. 513-534 22 p.

    Research output: Contribution to journalArticle

  147. PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

    Tibarewal, P., Zilidis, G., Spinelli, L., Schurch, N., Maccario, H., Gray, A., Perera, N. M., Davidson, L., Barton, G. J. & Leslie, N. R. 2012 In : Science Signaling. 5, 213, p. ra18

    Research output: Contribution to journalArticle

  148. Structural and biochemical characterization of a trapped coenzyme a adduct of Caenorhabditis elegans glucosamine-6-phosphate N-acetyltransferase 1

    Dorfmueller, H. C., Fang, W., Rao, F. V., Blair, D. E., Attrill, H. & van Aalten, D. M. F. 2012 In : Acta Crystallographica Section D: Biological Crystallography. 68, 8, p. 1019-1029 11 p.

    Research output: Contribution to journalArticle

  149. Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

    Cui, H., Carrero-Lérida, J., Silva, A. P. G., Whittingham, J. L., Brannigan, J. A., Ruiz-Pérez, L. M., Read, K. D., Wilson, K. S., González-Pacanowska, D. & Gilbert, I. H. 2012 In : Journal of Medicinal Chemistry. 55, 24, p. 10948-57 10 p.

    Research output: Contribution to journalArticle

  150. Synthesis of novel tetrazole C5-linked C0- and C2-ribonucleoside phosphoramidites using MePOM and POM groups for probing RNA catalysis

    Harusawa, S., Yoneyama, H., Fujisue, D., Nishiura, M., Fujitake, M., Usami, Y., Zhao, Z., Mcphee, S. A., Wilson, T. J. & Lilley, D. M. J. 2012 In : Tetrahedron Letters. 53, 44, p. 5891-5894 4 p.

    Research output: Contribution to journalArticle

  151. Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction

    Buckley, D. L., Van Molle, I., Gareiss, P. C., Tae, H. S., Michel, J., Noblin, D. J., Jorgensen, W. L., Ciulli, A. & Crews, C. M. 2012 In : Journal of the American Chemical Society. 134, 10, p. 4465-4468 4 p.

    Research output: Contribution to journalArticle

  152. Telomeres, tethers and trypanosomes

    Field, M. C., Horn, D., Alsford, S., Koreny, L. & Rout, M. P. 2012 In : Nucleus. 3, 6, p. 478-486 9 p.

    Research output: Contribution to journalArticle

  153. The kinomes of apicomplexan parasites

    Miranda-Saavedra, D., Gabaldón, T., Barton, G. J., Langsley, G. & Doerig, C. 2012 In : Microbes and Infection. 14, 10, p. 796-810 15 p.

    Research output: Contribution to journalArticle

  154. The structure and folding of helical junctions in RNA

    Lilley, D. M. J. 2012 Innovations in Biomolecular Modeling and Simulations. Schlick, T. (ed.). Cambridge: Royal Society of Chemistry, (RSC Biomolecular Sciences).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  155. The structure and folding of kink turns in RNA

    Lilley, D. M. J. 2012 In : Wiley Interdisciplinary Reviews: RNA. 3, 6, p. 797-805 9 p.

    Research output: Contribution to journalArticle

  156. The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces

    Wong, E., Vaaje-Kolstad, G., Ghosh, A., Hurtado-Guerrero, R., Konarev, P. V., Ibrahim, A. F. M., Svergun, D. I., Eijsink, V. G. H., Chatterjee, N. S. & van Aalten, D. M. F. 2012 In : PLoS Pathogens. 8, 1, e1002373

    Research output: Contribution to journalArticle

  157. Whole organism high-content screening by label-free, image-based bayesian classification for parasitic diseases

    Paveley, R. A., Mansour, N. R., Hallyburton, I., Bleicher, L. S., Benn, A. E., Mikic, I., Guidi, A., Gilbert, I. H., Hopkins, A. L. & Bickle, Q. D. 2012 In : PLoS Neglected Tropical Diseases. 6, 7, e1762

    Research output: Contribution to journalArticle

  158. Investigation of copper(II) tetrafluoroborate catalysed epoxide opening

    Capes, A. S., Crossman, A. T., Webster, L. A., Ferguson, M. A. J. & Gilbert, I. H. 28 Dec 2011 In : Tetrahedron Letters. 52, 52, p. 7091-7094 4 p.

    Research output: Contribution to journalArticle

  159. Protein O-GlcNAcylation is required for fibroblast growth factor signaling in Drosophila

    Mariappa, D., Sauert, K., Marino, K., Turnock, D., Webster, R., van Aalten, D. M. F., Ferguson, M. A. J. & Muller, H. A. J. 20 Dec 2011 In : Science Signaling. 4, 204, p. - 8 p.ra89

    Research output: Contribution to journalArticle

  160. Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

    Cleghorn, L. A. T., Woodland, A., Collie, I. T., Torrie, L. S., Norcross, N., Luksch, T., Mpamhanga, C., Walker, R. G., Mottram, J. C., Brenk, R., Frearson, J. A., Gilbert, I. H. & Wyatt, P. G. 9 Dec 2011 In : ChemMedChem. 6, 12, p. 2214-2224 11 p.

    Research output: Contribution to journalArticle

  161. Syringyl lignin is unaltered by severe sinapyl alcohol dehydrogenase suppression in tobacco

    Barakate, A., Stephens, J., Goldie, A., Hunter, W. N., Marshall, D., Hancock, R. D., Lapierre, C., Morreele, K., Boerjane, W. & Halpin, C. Dec 2011 In : Plant Cell. 23, 12, p. 4492-4506 15 p.

    Research output: Contribution to journalArticle

  162. The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system

    Rao, V. A., Shepherd, S. M., English, G., Coulthurst, S. J. & Hunter, W. N. Dec 2011 In : Acta Crystallographica Section D: Biological Crystallography. 67, p. 1065-1072 8 p.

    Research output: Contribution to journalArticle

  163. Chemical structure of Trichomonas vaginalis surface lipoglycan: a role for short galactose (beta 1-4/3) N-acetylglucosamine repeats in host cell interaction

    Ryan, C. M., Mehlert, A., Richardson, J. M., Ferguson, M. A. J. & Johnson, P. J. 25 Nov 2011 In : Journal of Biological Chemistry. 286, 47, p. 40494-40508 15 p.

    Research output: Contribution to journalArticle

  164. Rab28 function in trypanosomes: interactions with retromer and ESCRT pathways

    Lumb, J. H., Leung, K. F., Dubois, K. N. & Field, M. C. 15 Nov 2011 In : Journal of Cell Science. 124, P22, p. 3771-3783 13 p.

    Research output: Contribution to journalArticle

  165. From snoRNA to miRNA: Dual function regulatory non-coding RNAs

    Scott, M. S. & Ono, M. 1 Nov 2011 In : Biochimie. 93, 11, p. 1987-1992 6 p.

    Research output: Contribution to journalArticle

  166. DrugPred: A Structure-Based Approach To Predict Protein Druggability Developed Using an Extensive Nonredundant Data Set

    Krasowski, A., Muthas, D., Sarkar, A., Schmitt, S. & Brenk, R. Nov 2011 In : Journal of Chemical Information and Modeling. 51, 11, p. 2829-2842 14 p.

    Research output: Contribution to journalArticle

  167. Cell migration modulating compounds

    Schor, A. M., Schor, S. L., Marquez, R. & Norman, D. G. 19 Oct 2011 EP1917012

    Research output: Patent

  168. Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

    Patterson, S., Alphey, M. S., Jones, D. C., Shanks, E. J., Street, I. P., Frearson, J. A., Wyatt, P. G., Gilbert, I. H. & Fairlamb, A. H. 13 Oct 2011 In : Journal of Medicinal Chemistry. 54, 19, p. 6514-6530 17 p.

    Research output: Contribution to journalArticle

  169. Design, Synthesis, and Evaluation of 5 '-Diphenyl Nucleoside Analogues as Inhibitors of the Plasmodium falciparum dUTPase

    Hampton, S. E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Alexander Musso-Buendia, J., Recio, E., Kaiser, M., Whittingham, J. L., Roberts, S. M., Shevtsov, M., Brannigan, J. A., Kahnberg, P., Brun, R., Wilson, K. S., Gonzalez-Pacanowska, D., Johansson, N. G. & Gilbert, I. H. 4 Oct 2011 In : ChemMedChem. 6, 10, p. 1816-1831 16 p.

    Research output: Contribution to journalArticle

  170. Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

    Smith, V. C., Cleghorn, L. A. T., Woodland, A., Spinks, D., Hallyburton, I., Collie, I. T., Mok, N. Y., Norval, S., Brenk, R., Fairlamb, A. H., Frearson, J. A., Read, K. D., Gilbert, I. H. & Wyatt, P. G. 4 Oct 2011 In : ChemMedChem. 6, 10, p. 1832-1840 9 p.

    Research output: Contribution to journalArticle

  171. Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery

    Philpott, M., Yang, J., Tumber, T., Fedorov, O., Uttarkar, S., Filippakopoulos, P., Picaud, S., Keates, T., Felletar, I., Ciulli, A., Knapp, S. & Heightman, T. D. 1 Oct 2011 In : Molecular BioSystems. 7, 10, p. 2899-2908 10 p.

    Research output: Contribution to journalArticle

  172. Drug discovery initiative at the University of Dundee: hit-to-lead development for hat and generation of chemical tools

    Grimaldi, R., Urich, R., Sienkiewicz, N., Woodland, A., Urbaniak, M. D., Mathieson, T., Eberhard, D., Bantscheff, M., Drewes, G., Ferguson, M. A. J., Gilbert, I. H., Frearson, J. A., Wyatt, P. G. & Fairlamb, A. H. Oct 2011 In : Tropical Medicine & International Health. 16, Supp. 1, p. 212-212 1 p.

    Research output: Contribution to journalMeeting abstract

  173. Emerging role of surface plasmon resonance in fragment-based drug discovery

    Navratilova, I. & Hopkins, A. L. Oct 2011 In : Future Medicinal Chemistry. 3, 14, p. 1809-1820 12 p.

    Research output: Contribution to journalScientific review

  174. Mining the ChEMBL Database: An Efficient Chemoinformatics Workflow for Assembling an Ion Channel-Focused Screening Library

    Mok, N. Y. & Brenk, R. Oct 2011 In : Journal of Chemical Information and Modeling. 51, 10, p. 2449-2454 6 p.

    Research output: Contribution to journalArticle

  175. On the hunt for new diagnostic antigens for human African trypanosomiasis

    Sullivan, L., Carrington, M. & Ferguson, M. A. J. Oct 2011 In : Tropical Medicine & International Health. 16, p. 201-201 1 p.

    Research output: Contribution to journalMeeting abstract

  176. Probing the Dynamic Nature of Water Molecules and Their Influences on Ligand Binding in a Model Binding Site

    Cappel, D., Wahlstroem, R., Brenk, R. & Sotriffer, C. A. Oct 2011 In : Journal of Chemical Information and Modeling. 51, 10, p. 2581-2594 14 p.

    Research output: Contribution to journalArticle

  177. Visceral leishmaniasis and arsenic: an ancient poison contributing to antimonial treatment failure in the Indian subcontinent?

    Perry, M., Wyllie, S., Prajapati, V. K., Feldmann, J., Sundar, S., Boelaert, M. & Fairlamb, A. H. Oct 2011 In : Tropical Medicine & International Health. 16, S1, p. 66-67 2 p.

    Research output: Contribution to journalBook/Film/Article review

  178. A role for Snf2-related nucleosome-spacing enzymes in genome-wide nucleosome organization

    Gkikopoulos, T., Schofield, P., Singh, V., Pinskaya, M., Mellor, J., Smolle, M., Workman, J. L., Barton, G. J. & Owen-Hughes, T. 23 Sep 2011 In : Science. 333, 6050, p. 1758-1760 3 p.

    Research output: Contribution to journalArticle

  179. Pseudomonas aeruginosa 4-Amino-4-deoxychorismate lyase: spatial conservation of an active site tyrosine and classification of two types of enzyme

    O'Rourke, P. E. F., Eadsforth, T. C., Fyfe, P. K., Shepherd, S. M. & Hunter, W. N. 15 Sep 2011 In : PLoS ONE. 6, 9, p. - 8 p.e24158

    Research output: Contribution to journalArticle

  180. RNA Tertiary Interactions in a Riboswitch Stabilize the Structure of a Kink Turn

    Schroeder, K. T., Daldrop, P. & Lilley, D. M. J. 7 Sep 2011 In : Structure. 19, 9, p. 1233-1240 8 p.

    Research output: Contribution to journalArticle

  181. Computational approaches to selecting and optimising targets for structural biology

    Overton, I. M. & Barton, G. J. Sep 2011 In : Journal of Neuroscience Methods. 55, 1, p. 311 9 p.

    Research output: Contribution to journalArticle

  182. Mechanism of ubiquitylation by dimeric RING ligase RNF4

    Plechanovova, A., Jaffray, E. G., McMahon, S. A., Johnson, K. A., Navratilova, I., Naismith, J. H. & Hay, R. T. Sep 2011 In : Nature Structural & Molecular Biology. 18, 9, p. 1052-1059 8 p.

    Research output: Contribution to journalArticle

  183. Minimum information about a bioactive entity (MIABE)

    Orchard, S. , Al-Lazikani, B. , Bryant, S. , Clark, D. , Calder, E. , Dix, I. , Engkvist, O. , Forster, M. , Gaulton, A. , Gilson, M. , Glen, R. , Grigorov, M. , Hammond-Kosack, K. , Harland, L. , Hopkins, A. , Larminie, C. , Lynch, N. , Mann, R. K. , Murray-Rust, P. , Lo Piparo, E. & 6 others Southan, C., Steinbeck, C., Wishart, D., Hermjakob, H., Overington, J. & Thornton, J. Sep 2011 In : Nature Reviews Drug Discovery. 10, 9, p. 661-669 9 p.

    Research output: Contribution to journalScientific review

  184. Visceral Leishmaniasis and Arsenic: An Ancient Poison Contributing to Antimonial Treatment Failure in the Indian Subcontinent?

    Perry, M. R., Wyllie, S., Prajapati, V. K., Feldmann, J., Sundar, S., Boelaert, M. & Fairlamb, A. H. Sep 2011 In : PLoS Neglected Tropical Diseases. 5, 9, p. - 5 p.e1227

    Research output: Contribution to journalEditorial

  185. PChopper: high throughput peptide prediction for MRM/SRM transition design

    Afzal, V., Huang, J. T-J., Atrih, A. & Crowther, D. J. 15 Aug 2011 In : BMC Bioinformatics. 12, p. - 9 p.338

    Research output: Contribution to journalArticle

  186. NoD: a Nucleolar localization sequence detector for eukaryotic and viral proteins

    Scott, M. S., Troshin, P. V. & Barton, G. J. 3 Aug 2011 In : BMC Bioinformatics. 12, p. - 7 p.317

    Research output: Contribution to journalArticle

  187. Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites

    Hunter, W. N. Aug 2011 In : Current Topics in Medicinal Chemistry. 11, 16, p. 2048-2059 12 p.

    Research output: Contribution to journalScientific review

  188. Regulation of Caenorhabditis elegans p53/CEP-1-Dependent Germ Cell Apoptosis by Ras/MAPK Signaling

    Rutkowski, R., Dickinson, R., Stewart, G., Craig, A., Schimpl, M., Keyse, S. M. & Gartner, A. Aug 2011 In : PLoS Genetics. 7, 8, p. - 21 p.e1002238

    Research output: Contribution to journalArticle

  189. The impact of dedicated dermatology services on the awareness of cutaneous cancer risk and on attitudes towards UV exposure among transplant recipients

    Casabonne, D., Newton, R., Ismail, F., Mitchell, L., Lally, A., Imko-Walczuk, B., Wojnarowska, F., Proby, C. & Harwood, C. Aug 2011 In : Journal of Epidemiology and Community Health. 65, p. A107-A107 1 p.

    Research output: Contribution to journalBook/Film/Article review

  190. Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database

    Bickerton, G. R., Higueruelo, A. P. & Blundell, T. L. 29 Jul 2011 In : BMC Bioinformatics. 12, p. - 14 p.313

    Research output: Contribution to journalArticle

  191. Java bioinformatics analysis web services for multiple sequence alignment-JABAWS:MSA

    Troshin, P. V., Procter, J. B. & Barton, G. J. 15 Jul 2011 In : BMC Bioinformatics. 27, 14, p. 2001-2002 2 p.

    Research output: Contribution to journalArticle

  192. The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains

    Ryan, D. P., Sundaramoorthy, R., Martin, D., Singh, V. & Owen-Hughes, T. 6 Jul 2011 In : EMBO Journal. 30, 13, p. 2596-2609 14 p.

    Research output: Contribution to journalArticle

  193. Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei

    Marino, K., Guther, M. L. S., Wernimont, A. K., Qiu, W., Hui, R. & Ferguson, M. A. J. Jul 2011 In : Eukaryotic Cell. 10, 7, p. 985-997 13 p.

    Research output: Contribution to journalArticle

  194. Screening for GPCR Ligands Using Surface Plasmon Resonance

    Hopkins Navratilova, I., Besnard, J. & Hopkins, A. L. Jul 2011 In : ACS Medicinal Chemistry Letters. 2, 7, p. 549-554 6 p.

    Research output: Contribution to journalArticle

  195. Synthetic Neoglycoconjugates of Cell-Surface Phosphoglycans of Leishmania as Potential Anti-parasite Carbohydrate Vaccines

    Nikolaev, A. V. & Sizova, O. V. Jul 2011 In : Biochemistry-Moscow. 76, 7, p. 761-773 13 p.

    Research output: Contribution to journalScientific review

  196. The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential for novel treatments for schizophrenia

    Large, C. H., Bison, S., Sartori, I., Read, K. D., Gozzi, A., Quarta, D., Antolini, M., Hollands, E., Gill, C. H., Gunthorpe, M. J., Idris, N., Neill, J. C. & Alvaro, G. S. Jul 2011 In : Journal of Pharmacology and Experimental Therapeutics. 338, 1, p. 100-113 14 p.

    Research output: Contribution to journalArticle

  197. Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

    Dow, G. S. , Milner, E. , Bathurst, I. , Bhonsle, J. , Caridha, D. , Gardner, S. , Gerena, L. , Kozar, M. , Lanteri, C. , Mannila, A. , McCalmont, W. , Moon, J. , Read, K. D. , Norval, S. , Roncal, N. , Shackleford, D. M. , Sousa, J. , Steuten, J. , White, K. L. , Zeng, Q. & 1 others Charman, S. A. 6 Jun 2011 In : Malaria Journal. 10, p. - 11 p.150

    Research output: Contribution to journalArticle

  198. Antimicrobial drug discovery

    Fairlamb, A. & Cole, S. Jun 2011 In : Future Microbiology. 6, 6, p. 601-602 2 p.

    Research output: Contribution to journalEditorial

  199. Bisdionin C-A rationally designed, submicromolar inhibitor of family 18 chitinases

    Schuettelkopf, A. W., Andersen, O. A., Rao, F. V., Allwood, M., Rush, C. L., Eggleston, I. M. & van Aalten, D. M. F. Jun 2011 In : ACS Medicinal Chemistry Letters. 2, 6, p. 428-432 5 p.

    Research output: Contribution to journalArticle

  200. High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

    Alsford, S., Turner, D. J., Obado, S. O., Sanchez-Flores, A., Glover, L., Berriman, M., Hertz-Fowler, C. & Horn, D. Jun 2011 In : Genome Research. 21, 6, p. 915-924 10 p.

    Research output: Contribution to journalArticle

  201. Probing Elongating and Branching beta-D-Galactosyltransferase Activities in Leishmania Parasites by Making Use of Synthetic Phosphoglycans

    Sizova, O. V., Ross, A. J., Ivanova, I. A., Borodkin, V. S., Ferguson, M. A. J. & Nikolaev, A. V. Jun 2011 In : ACS Chemical Biology. 6, 6, p. 648-657 10 p.

    Research output: Contribution to journalArticle

  202. Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor

    Sutherland, T. E., Andersen, O. A., Betou, M., Eggleston, I. M., Maizels, R. M., van Aalten, D. & Allen, J. E. 27 May 2011 In : Chemistry & Biology. 18, 5, p. 569-579 11 p.

    Research output: Contribution to journalArticle

  203. Design of molecules

    Hopkins, A. & Besnard, J. 26 May 2011 PCT/GB2010/051940

    Research output: Patent

  204. The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4

    Gkikopoulos, T., Singh, V., Tsui, K., Awad, S., Renshaw, M. J., Scholfield, P., Barton, G. J., Nislow, C., Tanaka, T. U. & Owen-Hughes, T. 18 May 2011 In : EMBO Journal. 30, 10, p. 1919-1927 9 p.

    Research output: Contribution to journalArticle

  205. A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation

    Sugden, C., Ross, S., Annesley, S. J., Cole, C., Bloomfield, G., Ivens, A., Skelton, J., Fisher, P. R., Barton, G. & Williams, J. G. 15 May 2011 In : Developmental Biology. 353, 2, p. 290-301 12 p.

    Research output: Contribution to journalArticle

  206. Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus

    Overton, I. M., Graham, S., Gould, K. A., Hinds, J., Botting, C. H., Shirran, S., Barton, G. J. & Coote, P. J. 12 May 2011 In : BMC Systems Biology. 5, p. - 16 p.68

    Research output: Contribution to journalArticle

  207. Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate

    Morgan, R. E., Batot, G. O., Dement, J. M., Rao, V. A., Eadsforth, T. C. & Hunter, W. N. 9 May 2011 In : BMC Structural Biology. 11, p. - 9 p.21

    Research output: Contribution to journalArticle

  208. MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

    Filippi, B. M., de los Heros, P., Mehellou, Y., Navratilova, I., Gourlay, R., Deak, M., Plater, L., Toth, R., Zeqiraj, E. & Alessi, D. R. 4 May 2011 In : EMBO Journal. 30, 9, p. 1730-1741 12 p.

    Research output: Contribution to journalArticle

  209. Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei

    Abdelwahab, N. Z., Urbaniak, M. D., Ferguson, M. A. J. & Crossman, A. T. 1 May 2011 In : Carbohydrate Research. 346, 6, p. 708-714 7 p.

    Research output: Contribution to journalArticle

  210. Elongator protein 3b negatively regulates ribosomal DNA transcription in African Trypanosomes

    Alsford, S. & Horn, D. May 2011 In : Molecular and Cellular Biology. 31, 9, p. 1822-1832 11 p.

    Research output: Contribution to journalArticle

  211. Finding New Hits in Neglected Disease Projects: Target or Phenotypic Based Screening?

    Gilbert, I. H., Leroy, D. & Frearson, J. A. May 2011 In : Current Topics in Medicinal Chemistry. 11, 10, p. 1284-1291 8 p.

    Research output: Contribution to journalScientific review

  212. Identification of human miRNA precursors that resemble box C/D snoRNAs

    Ono, M., Scott, M. S., Yamada, K., Avolio, F., Barton, G. J. & Lamond, A. I. May 2011 In : Nucleic Acids Research. 39, 9, p. 3879-3891 13 p.

    Research output: Contribution to journalArticle

  213. Methylglyoxal metabolism in trypanosomes and leishmania

    Wyllie, S. & Fairlamb, A. H. May 2011 In : Seminars in Cell & Developmental Biology. 22, 3, p. 271-277 7 p.

    Research output: Contribution to journalScientific review

  214. Progress in Neglected Disease Drug Discovery

    Hopkins, A. L. & Wyatt, P. G. May 2011 In : Current Topics in Medicinal Chemistry. 11, 10, p. 1215-1215 1 p.

    Research output: Contribution to journalEditorial

  215. Rapid Analysis of Pharmacology for Infectious Diseases

    Hopkins, A. L., Bickerton, G. R., Carruthers, I. M., Boyer, S. K., Rubin, H. & Overington, J. P. May 2011 In : Current Topics in Medicinal Chemistry. 11, 10, p. 1292-1300 9 p.

    Research output: Contribution to journalScientific review

  216. Target Validation: Linking Target and Chemical Properties to Desired Product Profile

    Wyatt, P. G., Gilbert, I. H., Read, K. D. & Fairlamb, A. H. May 2011 In : Current Topics in Medicinal Chemistry. 11, 10, p. 1275-1283 9 p.

    Research output: Contribution to journalScientific review

  217. Exploiting the high-resolution crystal structure of Staphylococcus aureus MenH to gain insight into enzyme activity

    Dawson, A., Fyfe, P. K., Gillet, F. & Hunter, W. N. 22 Apr 2011 In : BMC Structural Biology. 11, p. - 11 p.19

    Research output: Contribution to journalArticle

  218. Evaluation of three novel azasterols against Toxoplasma gondii

    Martins-Duarte, É. S., Lemgruber, L., de Souza, W., Vommaro, R. C., Lorente, S. O., Gros, L., Magaraci, F. & Gilbert, I. H. 19 Apr 2011 In : Veterinary Parasitology. 177, 1-2, p. 157-161 5 p.

    Research output: Contribution to journalArticle

  219. beta-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase

    Baragana, B., McCarthy, O., Sanchez, P., Bosch-Navarrete, C., Kaiser, M., Brun, R., Whittingham, J. L., Roberts, S. M., Zhou, X-X., Wilson, K. S., Johansson, N. G., Gonzalez-Pacanowska, D. & Gilbert, I. H. 1 Apr 2011 In : Bioorganic & Medicinal Chemistry. 19, 7, p. 2378-2391 14 p.

    Research output: Contribution to journalArticle

  220. Developing small molecule drugs to rescue nonsense mutations in disease-causing genes

    Nomura, T., Gartner, U., McElroy, S., Torrie, L., Pourreyron, C., South, A. P., Wood, G., Woodland, A., Frearson, J., Wyatt, P. & McLean, I. Apr 2011 In : Journal of Investigative Dermatology. 131, p. S67-S67 1 p.397

    Research output: Contribution to journalBook/Film/Article review

  221. XANNpred: Neural nets that predict the propensity of a protein to yield diffraction-quality crystals

    Overton, I. M., van Niekerk, C. A. J. & Barton, G. J. Apr 2011 In : Proteins: Structure, Function, and Bioinformatics. 79, 4, p. 1027-1033 7 p.

    Research output: Contribution to journalArticle

  222. Effect of PI3K-and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKBI-deficient mice

    Garcia-Martinez, J. M., Wullschleger, S., Preston, G., Guichard, S., Fleming, S., Alessi, D. R. & Duce, S. L. 29 Mar 2011 In : British Journal of Cancer. 104, 7, p. 1116-1125 10 p.

    Research output: Contribution to journalArticle

  223. Dissecting the Metabolic Roles of Pteridine Reductase 1 in Trypanosoma brucei and Leishmania major

    Ong, H. B., Sienkiewicz, N., Wyllie, S. & Fairlamb, A. H. 25 Mar 2011 In : Journal of Biological Chemistry. 286, 12, p. 10429-10438 10 p.

    Research output: Contribution to journalArticle

  224. Novel Ligands for a Purine Riboswitch Discovered by RNA-Ligand Docking

    Daldrop, P., Reyes, F. E., Robinson, D. A., Hammond, C. M., Lilley, D. M., Batey, R. T. & Brenk, R. 25 Mar 2011 In : Chemistry & Biology. 18, 3, p. 324-335 12 p.

    Research output: Contribution to journalArticle

  225. Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism

    Konig, J., Wyllie, S., Wells, G., Stevens, M. F., Wyatt, P. G. & Fairlamb, A. H. 11 Mar 2011 In : Journal of Biological Chemistry. 286, 10, p. 8523-8533 11 p.

    Research output: Contribution to journalArticle

  226. Multiwall carbon nanotubes as MRI contrast agents for tracking stem cells

    Vittorio, O., Duce, S. L., Pietrabissa, A. & Cuschieri, A. 4 Mar 2011 In : Nanotechnology. 22, 9, p. - 7 p.095706

    Research output: Contribution to journalArticle

  227. Microhomology-mediated deletion and gene conversion in African trypanosomes

    Glover, L., Jun, J. & Horn, D. Mar 2011 In : Nucleic Acids Research. 39, 4, p. 1372-1380 9 p.

    Research output: Contribution to journalArticle

  228. Molecular recognition: O-GlcNAc transfer: size matters

    Gay, L. M., Zheng, X. & van Aalten, D. M. F. Mar 2011 In : Nature Chemical Biology. 7, 3, p. 134-135 3 p.

    Research output: Contribution to journalComment/debate

  229. Substrate and product analogues as human O-GlcNAc transferase inhibitors

    Dorfmueller, H. C., Borodkin, V. S., Blair, D. E., Pathak, S., Navratilova, I. & van Aalten, D. M. F. Mar 2011 In : Amino Acids. 40, 3, p. 781-792 12 p.

    Research output: Contribution to journalArticle

  230. Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

    Spinks, D., Ong, H. B., Mpamhanga, C. P., Shanks, E. J., Robinson, D. A., Collie, I. T., Read, K. D., Frearson, J. A., Wyatt, P. G., Brenk, R., Fairlamb, A. H. & Gilbert, I. H. 7 Feb 2011 In : ChemMedChem. 6, 2, p. 302-308 7 p.

    Research output: Contribution to journalArticle

  231. Modified 5'-trityl nucleosides as inhibitors of plasmodium falciparum dUTPase

    Gilbert, I. H., Ruda, G. F., Nguyen, C., Kasinathan, G., Ziemkowski, P., Felczak, K., Kulikowski, T., Musso-Buendia, A., Ruiz-Pérez, L. M., González-Pacanowska, D., Sund, C., Zhou, X. X., Johansson, N. G., Kaiser, M. & Brun, R. 7 Feb 2011 In : ChemMedChem. 6, 2, p. 309-320 12 p.

    Research output: Contribution to journalArticle

  232. Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase

    Walton, J. G. A., Jones, D. C., Kiuru, P., Durie, A. J., Westwood, N. J. & Fairlamb, A. H. 7 Feb 2011 In : ChemMedChem. 6, 2, p. 321-328 8 p.

    Research output: Contribution to journalArticle

  233. PNAC: a protein nucleolar association classifier

    Scott, M. S., Boisvert, F-M., Lamond, A. I. & Barton, G. J. 27 Jan 2011 In : BMC Genomics. 12, p. - 14 p.74

    Research output: Contribution to journalArticle

  234. Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms

    Sainsbury, S., Bird, L., Rao, V., Shepherd, S. M., Stuart, D. I., Hunter, W. N., Owens, R. J. & Ren, J. 7 Jan 2011 In : Journal of Molecular Biology. 405, 1, p. 173-184 12 p.

    Research output: Contribution to journalArticle

  235. PIMS sequencing extension: a laboratory information management system for DNA sequencing facilities

    Troshin, P. V., Barton, G. J., Postis, V. L., Baldwin, S. A., Ashworth, D. & McPherson, M. J. 1 Jan 2011 In : BMC Research Notes. 4, 48, 48

    Research output: Contribution to journalArticle

  236. How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance

    Wullschleger, S., Sakamoto, K., Johnstone, L., Duce, S., Fleming, S. & Alessi, D. R. Jan 2011 In : Disease Models & Mechanisms. 4, 1, p. 95-103 9 p.

    Research output: Contribution to journalArticle

  237. Micro-magnetic resonance imaging study of live quail embryos during embryonic development

    Duce, S., Morrison, F., Welten, M., Baggott, G. & Tickle, C. Jan 2011 In : Magnetic Resonance Imaging. 29, 1, p. 132-139 8 p.

    Research output: Contribution to journalArticle

  238. Structure of recombinant Leishmania donovani pteridine reductase reveals a disordered active site

    Barrack, K. L., Tulloch, L. B., Burke, L-A., Fyfe, P. K. & Hunter, W. N. Jan 2011 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 67, p. 33-37 5 p.

    Research output: Contribution to journalArticle

  239. Triclosan is minimally effective in rodent malaria models

    Baschong, W., Wittlin, S., Inglis, K. A., Fairlamb, A. H., Croft, S. L., Kumar, T. R. S., Fidock, D. A. & Brun, R. Jan 2011 In : Nature Medicine. 17, 1, p. 33-34 2 p.

    Research output: Contribution to journalLetter

  240. Characterization of in vivo metabolites of WR319691, a novel compound with activity against Plasmodium falciparum

    Milner, E., Sousa, J., Pybus, B., Melendez, V., Gardner, S., Grauer, K., Moon, J., Carroll, D., Auschwitz, J., Gettayacamin, M., Lee, P., Leed, S., McCalmont, W., Norval, S., Tungtaeng, A., Zeng, Q., Kozar, M., Read, K. D., Li, Q. & Dow, G. 2011 In : European Journal of Drug Metabolism and Pharmacokinetics. 36, 3, p. 151-158 8 p.

    Research output: Contribution to journalArticle

  241. Comparison of the specificity of Trk inhibitors in recombinant and neuronal assays

    Martin, K. J., Shpiro, N., Traynor, R., Elliott, M. & Arthur, J. S. C. 2011 In : Neuropharmacology. 61, 1-2, p. 148-155 8 p.

    Research output: Contribution to journalArticle

  242. Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6

    Baker, N., Alsford, S. & Horn, D. 2011 In : Molecular and Biochemical Parasitology. 176, 1, p. 55-57 3 p.

    Research output: Contribution to journalArticle

  243. Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPase

    Recio, E., Musso-Buendía, A., Vidal, A. E., Ruda, G. F., Kasinathan, G., Nguyen, C., Ruiz-Pérez, L. M., Gilbert, I. H. & González-Pacanowska, D. 2011 In : European Journal of Medicinal Chemistry. 46, 8, p. 3309-3314 6 p.

    Research output: Contribution to journalArticle

  244. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis

    Dias, M. V. B., Snee, W. C., Bromfield, K. M., Payne, R. J., Palaninathan, S. K., Ciulli, A., Howard, N. I., Abell, C., Sacchettini, J. C. & Blundell, T. L. 2011 In : Biochemical Journal. 436, 3, p. 729-739 11 p.

    Research output: Contribution to journalArticle

  245. Synthetic glycosylphosphatidylinositol (GPI) anchors: how these complex molecules have been made

    Nikolaev, A. V. & Al-Maharik, N. 2011 In : Natural Product Reports. 28, 5, p. 970-1020 51 p.

    Research output: Contribution to journalScientific review

  246. Acetazolamide-based fungal chitinase inhibitors

    Schuettelkopf, A. W., Gros, L., Blair, D. E., Frearson, J. A., van Aalten, D. M. F. & Gilbert, I. H. 1 Dec 2010 In : Bioorganic & Medicinal Chemistry. 18, 23, p. 8334-8340 7 p.

    Research output: Contribution to journalArticle

  247. Crystal structure of Leishmania major ADP-ribosylation factor-like 1 and a classification of related GTPase family members in this Kinetoplastid

    Fleming, J. R., Dawson, A. & Hunter, W. N. Dec 2010 In : Molecular and Biochemical Parasitology. 174, 2, p. 141-144 4 p.

    Research output: Contribution to journalArticle

  248. Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase

    Marino, K., Guther, M. L. S., Wernimont, A. K., Amani, M., Hui, R. & Ferguson, M. A. J. Dec 2010 In : Glycobiology. 20, 12, p. 1619-1630 12 p.

    Research output: Contribution to journalArticle

  249. Molecular mechanisms underlying the control of antigenic variation in African trypanosomes

    Horn, D. & McCulloch, R. Dec 2010 In : Current Opinion in Microbiology. 13, 6, p. 700-705 6 p.

    Research output: Contribution to journalScientific review

  250. Pseudokinases-remnants of evolution or key allosteric regulators?

    Zeqiraj, E. & van Aalten, D. M. F. Dec 2010 In : Current Opinion in Structural Biology. 20, 6, p. 772-781 10 p.

    Research output: Contribution to journalArticle

  251. Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases

    Dorfmueller, H. C., Borodkin, V. S., Schimpl, M., Zheng, X., Kime, R., Read, K. D. & van Aalten, D. M. F. 24 Nov 2010 In : Chemistry & Biology. 17, 11, p. 1250-1255 6 p.

    Research output: Contribution to journalArticle

  252. Human OGA binds substrates in a conserved peptide recognition groove

    Schimpl, M., Schuettelkopf, A. W., Borodkin, V. S. & van Aalten, D. M. F. 15 Nov 2010 In : Biochemical Journal. 432, p. 1-7 7 p.

    Research output: Contribution to journalArticle

  253. Identification of a kappa-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

    Jones, D. C., Hallyburton, I., Stojanovski, L., Read, K. D., Frearson, J. A. & Fairlamb, A. H. 15 Nov 2010 In : Biochemical Pharmacology. 80, 10, p. 1478-1486 9 p.

    Research output: Contribution to journalArticle

  254. High-resolution whole-genome sequencing reveals that specific Chromatin Domains from most human chromosomes associate with nucleoli

    van Koningsbruggen, S., Gierlinski, M., Schofield, P., Martin, D., Barton, G. J., Ariyurek, Y., den Dunnen, J. T. & Lamond, A. I. 1 Nov 2010 In : Molecular Biology of the Cell. 21, 21, p. 3735-3748 14 p.

    Research output: Contribution to journalArticle

  255. A high-throughput in vitro screen to identify inhibitors of the trypanosoma brucei trypananthione synthethase activity

    Kramer, M., Torrie, L., Booker, M., Spinks, D., Barker, R. H., Oza, S., Harris, M., Frearson, J., Collie, I. & Fairlamb, A. Nov 2010 In : American Journal of Tropical Medicine and Hygiene. 83, 5 (Suppl.), p. 323-323 1 p.1083

    Research output: Contribution to journalBook/Film/Article review

  256. Central nervous system (CNS) exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous (IV) dosing in mice

    Dow, G. S., Milner, E., Caridha, D., Gardner, S., Lanteri, C., Kozar, M., Mannila, A., McCalmont, W., Melendez, V., Moon, J., Read, K., Norval, S., Roncal, N., Shackleford, D., Sousa, J., Stouten, J., White, K., Zeng, Q. & Charman, S. Nov 2010 p. 213-213 1 p.

    Research output: Contribution to conferenceAbstract

  257. Characterization and prediction of protein nucleolar localization sequences

    Scott, M. S., Boisvert, F-M., McDowall, M. D., Lamond, A. I. & Barton, G. J. Nov 2010 In : Nucleic Acids Research. 38, 21, p. 7388-7399 12 p.

    Research output: Contribution to journalArticle

  258. Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase

    Cui, H., Ruda, G. F., Carrero-Lerida, J., Ruiz-Perez, L. M., Gilbert, I. H. & Gonzalez-Pacanowska, D. Nov 2010 In : European Journal of Medicinal Chemistry. 45, 11, p. 5140-5149 10 p.

    Research output: Contribution to journalArticle

  259. Glycoinositolphosphorylceramide from Pathogenic Fungus Sporothrix schenckii Shows That Fatty Acid Hydroxylation Level Correlates with the Mycelium-Yeast Thermal-Induced Morphological Transition

    Medeiros, A., Bandini, G., Macedo, C., Ferguson, M., Kirsch, S., Soltwisch, J., Previato, J., Mendonca-Previato, L. & Peter-Katalinic, J. Nov 2010 In : Glycobiology. 20, 11, p. 1506-1506 1 p.

    Research output: Contribution to journalMeeting abstract

  260. Glycotyping of Trypanosoma brucei variant surface glycoprotein MITat1.8

    Mehlert, A., Sullivan, L. & Ferguson, M. A. J. Nov 2010 In : Molecular and Biochemical Parasitology. 174, 1, p. 74-77 4 p.

    Research output: Contribution to journalArticle

  261. O-Glcnacase substrate recognition involves both sugar and protein

    Schimpl, M., Schuettelkopf, A., Borodkin, V. S. & Van Aalten, D. M. F. Nov 2010 In : Glycobiology. 20, 11, p. 1481-1481 1 p.101

    Research output: Contribution to journalBook/Film/Article review

  262. O-Glcnacylation of TAB1 modulates TAK1-mediated cytokine release

    Pathak, S., Campbell, D., Ibrahim, A. & Van Aalten, D. M. F. Nov 2010 In : Glycobiology. 20, 11, p. 1478-1478 1 p.92

    Research output: Contribution to journalBook/Film/Article review

  263. RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease

    Alsford, S., Kemp, L. E., Kawahara, T. & Horn, D. Nov 2010 In : Molecular and Biochemical Parasitology. 174, 1, p. 70-73 4 p.

    Research output: Contribution to journalArticle

  264. Engineered biocompatible nanoparticles for in vivo imaging applications

    Chen, S., Wang, L., Duce, S. L., Brown, S., Lee, S., Melzer, A., Cuschieri, A. & Andre, P. 27 Oct 2010 In : Journal of the American Chemical Society. 132, 42, p. 15022-15029 8 p.

    Research output: Contribution to journalArticle

  265. Design and preparation of sterol mimetics as potential antiparasitics

    Gigante, F., Kaiser, M., Brun, R. & Gilbert, I. H. 15 Oct 2010 In : Bioorganic & Medicinal Chemistry. 18, 20, p. 7291-7301 11 p.

    Research output: Contribution to journalArticle

  266. Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum

    Cui, H., Ruiz-Perez, L. M., Gonzalez-Pacanowska, D. & Gilbert, I. H. 15 Oct 2010 In : Bioorganic & Medicinal Chemistry. 18, 20, p. 7302-7309 8 p.

    Research output: Contribution to journalArticle

  267. Drug discovery in academia: the third way?

    Frearson, J. & Wyatt, P. Oct 2010 In : Expert Opinion on Drug Discovery. 5, 10, p. 909-919 11 p.

    Research output: Contribution to journalScientific review

  268. Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates

    Wyllie, S., Mandal, G., Singh, N., Sundar, S., Fairlamb, A. H. & Chatterjee, M. Oct 2010 In : Molecular and Biochemical Parasitology. 173, 2, p. 162-164 3 p.

    Research output: Contribution to journalArticle

  269. Prophossi: automating expert validation of phosphopeptide-spectrum matches from tandem mass spectrometry

    Martin, D. M. A., Nett, I. R. E., Vandermoere, F., Barber, J. D., Morrice, N. A. & Ferguson, M. A. J. 1 Sep 2010 In : Bioinformatics. 26, 17, p. 2153-2159 7 p.

    Research output: Contribution to journalArticle

  270. Histone deacetylases play distinct roles in telomeric VSG expression site silencing in African trypanosomes

    Wang, Q-P., Kawahara, T. & Horn, D. Sep 2010 In : Molecular Microbiology. 77, 5, p. 1237-1245 9 p.

    Research output: Contribution to journalArticle

  271. Structure and reactivity of Bacillus subtilis MenD catalyzing the first committed step in menaquinone biosynthesis

    Dawson, A., Chen, M., Fyfe, P. K., Guo, Z. & Hunter, W. N. 13 Aug 2010 In : Journal of Molecular Biology. 401, 2, p. 253-264 12 p.

    Research output: Contribution to journalArticle

  272. Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif

    Klee, N., Wong, P. E., Baragana, B., El Mazouni, F., Phillips, M. A., Barrett, M. P. & Gilbert, I. H. 1 Aug 2010 In : Bioorganic & Medicinal Chemistry Letters. 20, 15, p. 4364-4366 3 p.

    Research output: Contribution to journalArticle

  273. Potentiation of the anticonvulsant efficacy of sodium channel inhibitors by an NK1-receptor antagonist in the rat

    Kalinichev, M., Bradford, A., Bison, S., Lucas, A., Sartori, I., Garbati, N., Andreetta, F., Bate, S., Austin, N. E., Jones, D. N. C., Read, K. D., Alvaro, G. & Large, C. H. Aug 2010 In : Epilepsia. 51, 8, p. 1543-1551 9 p.

    Research output: Contribution to journalArticle

  274. Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery

    Fyfe, P. K., Dawson, A., Hutchison, M-T., Cameron, S. & Hunter, W. N. Aug 2010 In : Acta Crystallographica Section D: Biological Crystallography. 66, p. 881-888 8 p.

    Research output: Contribution to journalArticle

  275. Structure of the three-way helical junction of the hepatitis C virus IRES element

    Ouellet, J., Melcher, S., Iqbal, A., Ding, Y. & Lilley, D. M. J. Aug 2010 In : RNA: a Publication of the RNA Society. 16, 8, p. 1597-1609 13 p.

    Research output: Contribution to journalArticle

  276. Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice

    Sienkiewicz, N., Ong, H. B. & Fairlamb, A. H. Aug 2010 In : Molecular Microbiology. 77, 3, p. 658-671 14 p.

    Research output: Contribution to journalArticle

  277. 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor

    Micheli, F. , Cavanni, P. , Andreotti, D. , Arban, R. , Benedetti, R. , Bertani, B. , Bettati, M. , Bettelini, L. , Bonanomi, G. , Braggio, S. , Carletti, R. , Checchia, A. , Corsi, M. , Fazzolari, E. , Fontana, S. , Marchioro, C. , Merlo-Pich, E. , Negri, M. , Oliosi, B. , Ratti, E. & 11 others Read, K. D., Roscic, M., Sartori, I., Spada, S., Tedesco, G., Tarsi, L., Terreni, S., Visentini, F., Zocchi, A., Zonzini, L. & Di Fabio, R. 8 Jul 2010 In : Journal of Medicinal Chemistry. 53, 13, p. 4989-5001 13 p.

    Research output: Contribution to journalArticle

  278. Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4 '-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness

    Durrant, J. D., Urbaniak, M. D., Ferguson, M. A. J. & McCammon, J. A. 8 Jul 2010 In : Journal of Medicinal Chemistry. 53, 13, p. 5025-5032 8 p.

    Research output: Contribution to journalArticle

  279. A fluorescence lifetime-based assay for serine and threonine kinases that is suitable for high-throughput screening

    Paterson, M. J., Dunsmore, C. J., Hurteaux, R., Maltman, B. A., Cotton, G. J. & Gray, A. 1 Jul 2010 In : Analytical Biochemistry. 402, 1, p. 54-64 11 p.

    Research output: Contribution to journalArticle

  280. Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis

    Sokolova, A. Y., Wyllie, S., Patterson, S., Oza, S. L., Read, K. D. & Fairlamb, A. H. Jul 2010 In : Antimicrobial Agents and Chemotherapy. 54, 7, p. 2893-2900 8 p.

    Research output: Contribution to journalArticle

  281. Know your chemical space

    Hopkins, A. L. & Bickerton, G. R. Jul 2010 In : Nature Chemical Biology. 6, 7, p. 482-483 2 p.

    Research output: Contribution to journalComment/debate

  282. Structural basis for the efficient phosphorylation of AZT-MP (3 '-azido-3 '-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

    Whittingham, J. L., Carrero-Lerida, J., Brannigan, J. A., Ruiz-Perez, L. M., Silva, A. P. G., Fogg, M. J., Wilkinson, A. J., Gilbert, I. H., Wilson, K. S. & Gonzalez-Pacanowska, D. 15 Jun 2010 In : Biochemical Journal. 428, p. 499-509 11 p.

    Research output: Contribution to journalArticle

  283. Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors

    Wang, S. , Midgley, C. A. , Scaërou, F. , Grabarek, J. B. , Griffiths, G. , Jackson, W. , Kontopidis, G. , McClue, S. J. , McInnes, C. , Meades, C. , Mezna, M. , Plater, A. , Stuart, I. , Thomas, M. P. , Wood, G. , Clarke, R. G. , Blake, D. G. , Zheleva, D. I. , Lane, D. P. , Jackson, R. C. & 2 others Glover, D. M. & Fischer, P. M. 10 Jun 2010 In : Journal of Medicinal Chemistry. 53, 11, p. 4367-4378 12 p.

    Research output: Contribution to journalArticle

  284. Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins

    Remenyi, J., Hunter, C. J., Cole, C., Ando, H., Impey, S., Monk, C. E., Martin, K. J., Barton, G. J., Hutvagner, G. & Arthur, J. S. C. 1 Jun 2010 In : Biochemical Journal. 428, 2, p. 281-291 11 p.

    Research output: Contribution to journalArticle

  285. Nucleophilic catalysis of acylhydrazone equilibration for protein-directed dynamic covalent chemistry

    Bhat, V. T., Caniard, A. M., Luksch, T., Brenk, R., Campopiano, D. J. & Greaney, M. F. Jun 2010 In : Nature Chemistry. 2, 6, p. 490-497 8 p.

    Research output: Contribution to journalArticle

  286. Nuclear DBF-2-related Kinases Are Essential Regulators of Cytokinesis in Bloodstream Stage Trypanosoma brucei

    Ma, J., Benz, C., Grimaldi, R., Stockdale, C., Wyatt, P., Frearson, J. & Hammarton, T. C. 14 May 2010 In : Journal of Biological Chemistry. 285, 20, p. 15356-15368 13 p.

    Research output: Contribution to journalArticle

  287. Analysis of Human Small Nucleolar RNAs (snoRNA) and the Development of snoRNA Modulator of Gene Expression Vectors

    Ono, M., Yamada, K., Avolio, F., Scott, M. S., van Koningsbruggen, S., Barton, G. J. & Lamond, A. I. 1 May 2010 In : Molecular Biology of the Cell. 21, 9, p. 1569-1584 16 p.

    Research output: Contribution to journalArticle

  288. Application of electrospray mass spectrometry to the structural determination of glycosylphosphatidylinositol membrane anchors

    Nett, I. R. E., Mehlert, A., Lamont, D. & Ferguson, M. A. J. May 2010 In : Glycobiology. 20, 5, p. 576-585 10 p.

    Research output: Contribution to journalArticle

  289. Optimization of the interligand Overhauser effect for fragment linking: Application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase

    Sledz, P., Silvestre, H. L., Hung, A. W., Ciulli, A., Blundell, T. L. & Abell, C. 7 Apr 2010 In : Journal of the American Chemical Society. 132, 13, p. 4544-4545 2 p.

    Research output: Contribution to journalArticle

  290. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

    van Aalten, D. M. F. , Gilbert, I. H. & 24 others Frearson, J. A., Brand, S., McElroy, S. P., Cleghorn, L. A. T., Smid, O., Stojanovski, L., Price, H. P., Guther, M. L. S., Torrie, L. S., Robinson, D. A., Hallyburton, I., Mpamhanga, C. P., Brannigan, J. A., Wilkinson, A. J., Hodgkinson, M., Hui, R., Qiu, W., Raimi, O. G., Brenk, R., Read, K. D., Fairlamb, A. H., Ferguson, M. A. J., Smith, D. F. & Wyatt, P. G. 1 Apr 2010 In : Nature. 464, 7289, p. 728-732 7 p.

    Research output: Contribution to journalArticle

  291. Fragment Screening by Surface Plasmon Resonance

    Hopkins Navratilova, I. & Hopkins, A. L. Apr 2010 In : ACS Medicinal Chemistry Letters. 1, 1, p. 44-48 5 p.

    Research output: Contribution to journalArticle

  292. Regulation of plant gene expression by alternative splicing

    Simpson, C. G., Manthri, S., Raczynska, K. D., Kalyna, M., Lewandowska, D., Kusenda, B., Maronova, M., Szweykowska-Kulinska, Z., Jarmolowski, A., Barta, A. & Brown, J. W. S. Apr 2010 In : Biochemical Society Transactions. 38, 2, p. 667-671 5 p.

    Research output: Contribution to journalArticle

  293. Shotgun Proteomics in the discovery of biomarkers of non-alcoholic fatty liver disease: an improved methodology

    Miller, M., Jafferbhoy, H., Ferguson, M. A. J. & Dillon, J. Apr 2010 In : Gut. 59, S1, p. A104-A104 1 p.

    Research output: Contribution to journalSpecial issue

  294. Structure of Trypanosoma brucei glutathione synthetase: domain and loop alterations in the catalytic cycle of a highly conserved enzyme

    Fyfe, P. K., Alphey, M. S. & Hunter, W. N. Apr 2010 In : Molecular and Biochemical Parasitology. 170, 2, p. 93-99 7 p.

    Research output: Contribution to journalArticle

  295. The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist

    Rimland, J., Dunne, A., Hunjan, S. S., Sasse, R., Uings, I., Montanari, D., Caivano, M., Shah, P., Standing, D., Gray, D., Brown, D., Cairns, W., Trump, R., Smith, P. W., Bertheleme, N., D'Alessandro, P., Gul, S., Vimal, M., Smith, D. N. & Watson, S. P. Apr 2010 In : Bioorganic & Medicinal Chemistry Letters. 20, 7, p. 2340-3 4 p.

    Research output: Contribution to journalArticle

  296. Water-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis

    Nicoletti, S., Seifert, K. & Gilbert, I. H. Apr 2010 In : Bioorganic & Medicinal Chemistry. 18, 7, p. 2559-2565 7 p.

    Research output: Contribution to journalArticle

  297. 1-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors

    Micheli, F. , Cavanni, P. , Arban, R. , Benedetti, R. , Bertani, B. , Bettati, M. , Bettelini, L. , Bonanomi, G. , Braggio, S. , Checchia, A. , Davalli, S. , Di Fabio, R. , Fazzolari, E. , Fontana, S. , Marchioro, C. , Minick, D. , Negri, M. , Oliosi, B. , Read, K. D. , Sartori, I. & 6 others Tedesco, G., Tarsi, L., Terreni, S., Visentini, F., Zocchi, A. & Zonzini, L. 25 Mar 2010 In : Journal of Medicinal Chemistry. 53, 6, p. 2534-2551 18 p.

    Research output: Contribution to journalArticle

  298. N-myristoyl transferase inhibitors

    Brand, S., Wyatt, P., Thompson, S., Smith, V., Bayliss, T., Harrison, J., Norcross, N., Cleghorn, L., Gilbert, I. & Brenk, R. 11 Mar 2010 PCT/GB2009/002084

    Research output: Patent

  299. Erratum - a case-control study of cutaneous squamous cell carcinoma among Caucasian organ transplant recipients: The role of antibodies against human papillomavirus and other risk factors (vol 125, pg 1935, 2009)

    Casabonne, D., Lally, A., Mitchell, L., Michael, K. M., Waterboer, T., Pawlita, M., Imko-Walczuk, B., Wojnarowska, F., Proby, C., Harwood, C. & Newton, R. 1 Mar 2010 In : International Journal of Cancer. 126, 5, p. 1282-1282 1 p.

    Research output: Contribution to journalArticle

  300. Visualizing biological data: now and in the future

    O'Donoghue, S. I., Gavin, A-C., Gehlenborg, N., Goodsell, D. S., Hériché, J-K., Nielsen, C. B., North, C., Olson, A. J., Procter, J. B., Shattuck, D. W., Walter, T. & Wong, B. 1 Mar 2010 In : Nature Methods. 7, 3 SUPPL., p. S2-S4

    Research output: Contribution to journalArticle

  301. A triclinic crystal form of Escherichia coli 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure

    Kalinowska-Tluscik, J., Miallau, L., Gabrielsen, M., Leonard, G. A., McSweeney, S. M. & Hunter, W. N. Mar 2010 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 66, p. 237-241 5 p.

    Research output: Contribution to journalArticle

  302. Assessing brain free fraction in early drug discovery

    Read, K. D. & Braggio, S. Mar 2010 In : Expert Opinion on Drug Metabolism & Toxicology. 6, 3, p. 337-344 8 p.

    Research output: Contribution to journalScientific review

  303. Visualization of multiple alignments, phylogenies and gene family evolution

    Procter, J. B., Thompson, J., Letunic, I., Creevey, C., Jossinet, F. & Barton, G. J. Mar 2010 In : Nature Methods. 7, 3, p. S16-S25 10 p.

    Research output: Contribution to journalScientific review

  304. Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds

    Dorfmueller, H. C. & van Aalten, D. M. F. 19 Feb 2010 In : FEBS Letters. 584, 4, p. 694-700 7 p.

    Research output: Contribution to journalArticle

  305. The genetic diversity and evolution of field pea (Pisum) studied by high throughput retrotransposon based insertion polymorphism (RBIP) marker analysis

    Jing, R., Vershinin, A., Grzebyta, J., Shaw, P., Smykal, P., Marshall, D., Ambrose, M. J., Ellis, T. H. N. & Flavell, A. J. 15 Feb 2010 In : BMC Evolutionary Biology. 10, p. - 20 p.44

    Research output: Contribution to journalArticle

  306. Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

    Shanks, E. J., Ong, H. B., Robinson, D. A., Thompson, S., Sienkiewicz, N., Fairlamb, A. H. & Frearson, J. A. 15 Jan 2010 In : Analytical Biochemistry. 396, 2, p. 194-203 10 p.

    Research output: Contribution to journalArticle

  307. Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the Leishmaniases

    Tulloch, L. B., Martini, V. P., Iulek, J., Huggan, J. K., Lee, J. H., Gibson, C. L., Smith, T. K., Suckling, C. J. & Hunter, W. N. 14 Jan 2010 In : Journal of Medicinal Chemistry. 53, 1, p. 221-229 9 p.

    Research output: Contribution to journalArticle

  308. A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology

    Durrant, J. D., Amaro, R. E., Xie, L., Urbaniak, M. D., Ferguson, M. A. J., Haapalainen, A., Chen, Z., Di Guilmi, A. M., Wunder, F., Bourne, P. E. & McCammon, J. A. Jan 2010 In : PLoS Computational Biology. 6, 1, p. - 8 p.e1000648

    Research output: Contribution to journalArticle

  309. Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T-cruzi

    Jones, D. C., Ariza, A., Chow, W-H. A., Oza, S. L. & Fairlamb, A. H. Jan 2010 In : Molecular and Biochemical Parasitology. 169, 1, p. 12-19 8 p.

    Research output: Contribution to journalArticle

  310. Micro-magnetic resonance imaging and embryological analysis of wild-type and pma mutant mice with clubfoot

    Duce, S., Madrigal, L., Schmidt, K., Cunningham, C., Liu, G., Barker, S., Tennant, G., Tickle, C., Chudek, S. & Miedzybrodzka, Z. Jan 2010 In : Journal of Anatomy. 216, 1, p. 108-120 13 p.

    Research output: Contribution to journalArticle

  311. Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects

    Price, H. P., Guther, M. L. S., Ferguson, M. A. J. & Smith, D. F. Jan 2010 In : Molecular and Biochemical Parasitology. 169, 1, p. 55-58 4 p.

    Research output: Contribution to journalArticle

  312. The tetrahydrobiopterin pathway and pain

    Naylor, A. M., Pojasek, K. R., Hopkins, A. L. & Blagg, J. Jan 2010 In : Current Opinion in Investigational Drugs. 11, 1, p. 19-30 12 p.

    Research output: Contribution to journalScientific review

  313. An ontology for description of drug discovery investigations

    Qi, D., King, R. D., Hopkins, A. L., Bickerton, G. R. J. & Soldatova, L. N. 2010 In : Journal of Integrative Bioinformatics. 7, 3

    Research output: Contribution to journalArticle

  314. Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds

    Ruda, G. F., Wong, P. E., Alibu, V. P., Norval, S., Read, K. D., Barrett, M. P. & Gilbert, I. H. 2010 In : Journal of Medicinal Chemistry. 53, 16, p. 6071-6078 8 p.

    Research output: Contribution to journalArticle

  315. Chemical synthesis of parasitic glycoconjugates and phosphoglycans

    Al-Maharik, N., Tee, J. A. & Nikolaev, A. V. 2010 Microbial glycobiology: structures, relevance and applications. Moran, A. P., Holst, O., Brennan, P. J. & von Itzstein, M. (eds.). London: Academic Press, p. 477-548 72 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  316. On the synthesis of N-maleoyl amino acids in aqueous media: cautionary tales for the unwary traveller

    Paterson, M. J. & Jovanovic, A. 2010 In : ARKIVOC. p. 11-16 6 p.

    Research output: Contribution to journalArticle

  317. The Scottish Structural Proteomics Facility: targets, methods and outputs

    Oke, M. , Carter, L. G. , Johnson, K. A. , Liu, H. , McMahon, S. A. , Yan, X. , Kerou, M. , Weikart, N. D. , Kadi, N. , Sheikh, M. A. , Schmelz, S. , Dorward, M. , Zawadzki, M. , Cozens, C. , Falconer, H. , Powers, H. , Overton, I. M. , van Niekerk, C. A. J. , Peng, X. , Patel, P. & 11 others Garrett, R. A., Prangishvili, D., Botting, C. H., Coote, P. J., Dryden, D. T. F., Barton, G. J., Schwarz-Linek, U., Challis, G. L., Taylor, G. L., White, M. F. & Naismith, J. H. 2010 In : Journal of Structural and Functional Genomics. 11, 2, p. 167-80 14 p.

    Research output: Contribution to journalArticle

  318. Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase

    Ruda, G. F., Campbell, G., Alibu, V. P., Barrett, M. P., Brenk, R. & Gilbert, I. H. 2010 In : Bioorganic & Medicinal Chemistry. 18, 14, p. 5056-5062 7 p.

    Research output: Contribution to journalArticle

  319. Chemical Validation of Trypanothione Synthetase a potential drug targer for human trypanosomiasis

    Torrie, L. S., Wyllie, S., Spinks, D., Oza, S. L., Thompson, S., Harrison, J. R., Gilbert, I. H., Wyatt, P. G., Fairlamb, A. H. & Frearson, J. A. 25 Dec 2009 In : Journal of Biological Chemistry. 284, 52, p. 36137-36145 9 p.

    Research output: Contribution to journalArticle

  320. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

    Zeqiraj, E., Filippi, B. M., Deak, M., Alessi, D. R. & van Aalten, D. M. F. 18 Dec 2009 In : Science. 326, 5960, p. 1707-1711 5 p.

    Research output: Contribution to journalArticle

  321. Thiolactomycin analogues as potential anti-Toxoplasma gondii agents

    Martins-Duarte, E. S., de Souza, W., Vommaro, R. C., Jones, S. M., Gilbert, I. H. & Atella, G. C. 1 Dec 2009 In : Parasitology International. 58, 4, p. 411-415 5 p.

    Research output: Contribution to journalArticle

  322. Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs

    Cole, C., Sobala, A., Lu, C., Thatcher, S. R., Bowman, A., Brown, J. W. S., Green, P. J., Barton, G. J. & Hutvagner, G. Dec 2009 In : RNA: a Publication of the RNA Society. 15, 12, p. 2147-2160 14 p.

    Research output: Contribution to journalArticle

  323. HTS and hit finding in academia - from chemical genomics to drug discovery

    Frearson, J. A. & Collie, I. T. Dec 2009 In : Drug Discovery Today. 14, 23-24, p. 1150-1158 9 p.

    Research output: Contribution to journalArticle

  324. Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

    Spinks, D., Shanks, E. J., Cleghorn, L. A. T., McElroy, S., Jones, D., James, D., Fairlamb, A. H., Frearson, J. A., Wyatt, P. G. & Gilbert, I. H. Dec 2009 In : ChemMedChem. 4, 12, p. 2060-2069 10 p.

    Research output: Contribution to journalArticle

  325. A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry

    Scott, D. E., Dawes, G. J., Ando, M., Abell, C. & Ciulli, A. 23 Nov 2009 In : ChemBioChem. 10, 17, p. 2772-2779 8 p.

    Research output: Contribution to journalArticle

  326. Drug discovery Predicting promiscuity

    Hopkins, A. L. 12 Nov 2009 In : Nature. 462, 7270, p. 167-168 2 p.

    Research output: Contribution to journalEditorial

  327. A requirement for GDP-L-fucose in Leishmania inferred by rescue of D-arabinopyranose/L-fucose salvage mutants (Fkp40(-)/Afkp80(-)) by expression of GDP-L-fuc synthetic enzymes

    Guo, H., Novozhilova, N. M., Bandini, G., Notton, T., Turco, S. J., Ferguson, M. A. J. & Beverley, S. M. Nov 2009 In : Glycobiology. 19, 11, p. 1297-1297 1 p.

    Research output: Contribution to journalMeeting abstract

  328. Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods

    Wyllie, S., Oza, S. L., Patterson, S., Spinks, D., Thompson, S. & Fairlamb, A. H. Nov 2009 In : Molecular Microbiology. 74, 3, p. 529-540 12 p.

    Research output: Contribution to journalArticle

  329. Preferential Activation of TLR2/6 Heterodimer by Synthetic Trypanosoma Cruzi Trypomastigote Glycosylphosphatidylinositols is Enhanced by Coexpression of CD14 and CD36

    Nohara, L., Yashunsky, D., Ferguson, M., Nikolaev, A. & Almeida, I. Nov 2009 In : Glycobiology. 19, 11, p. 1361-1361 1 p.247

    Research output: Contribution to journalMeeting abstract

  330. Proteomic scale high-sensitivity analyses of GPI membrane anchors

    Mehlert, A. & Ferguson, M. A. J. Nov 2009 In : Glycoconjugate Journal. 26, 8, p. 915-921 7 p.

    Research output: Contribution to journalArticle

  331. Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase

    Hung, A. W., Silvestre, H. L., Wen, S., Ciulli, A., Blundell, T. L. & Abell, C. 26 Oct 2009 In : Angewandte Chemie International Edition. 48, 45, p. 8452-8456 5 p.

    Research output: Contribution to journalArticle

  332. 1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein

    Kelleher, M. O., McMahon, M., Eggleston, I. M., Dixon, M. J., Taguchi, K., Yamamoto, M. & Hayes, J. D. Oct 2009 In : Carcinogenesis. 30, 10, p. 1754-1762 9 p.

    Research output: Contribution to journalArticle

  333. The Orientation of a Tandem POTRA Domain Pair, of the Beta-Barrel Assembly Protein BamA, Determined by PELDOR Spectroscopy

    Ward, R., Zoltner, M., Beer, L., El Mkami, H., Henderson, I. R., Palmer, T. & Norman, D. G. 9 Sep 2009 In : Structure. 17, 9, p. 1187-1194 8 p.

    Research output: Contribution to journalArticle

  334. ABC50 promotes translation initiation in mammalian cells

    Paytubi, S., Wang, X., Lam, Y. W., Izquierdo, L., Hunter, M. J., Jan, E., Hundal, H. S. & Proud, C. G. 4 Sep 2009 In : Journal of Biological Chemistry. 284, 36, p. 24061-24073 13 p.

    Research output: Contribution to journalArticle

  335. Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases

    Izquierdo, L., Schulz, B. L., Rodrigues, J. A., Guther, M. L. S., Procter, J. B., Barton, G. J., Aebi, M. & Ferguson, M. A. J. 2 Sep 2009 In : EMBO Journal. 28, 17, p. 2650-2661 12 p.

    Research output: Contribution to journalArticle

  336. Fate of Glycosylphosphatidylinositol (GPI)-Less Procyclin and Characterization of Sialylated Non-GPI-Anchored Surface Coat Molecules of Procyclic-Form Trypanosoma brucei

    Guether, M. L. S., Beattie, K., Lamont, D. J., James, J., Prescott, A. R. & Ferguson, M. A. J. Sep 2009 In : Eukaryotic Cell. 8, 9, p. 1407-1417 11 p.

    Research output: Contribution to journalArticle

  337. Human miRNA Precursors with Box H/ACA snoRNA Features

    Scott, M. S., Avolio, F., Ono, M., Lamond, A. I. & Barton, G. J. Sep 2009 In : PLoS Computational Biology. 5, 9, p. - 13 p.e1000507

    Research output: Contribution to journalArticle

  338. The emerging academic drug-discovery sector

    Wyatt, P. G. Sep 2009 In : Future Medicinal Chemistry. 1, 6, p. 1013-1017 5 p.

    Research output: Contribution to journalEditorial

  339. The ethanolamine branch of the Kennedy pathway is essential in the bloodstream form of Trypanosoma brucei

    Gibellini, F., Hunter, W. N. & Smith, T. K. Sep 2009 In : Molecular Microbiology. 73, 5, p. 826-843 18 p.

    Research output: Contribution to journalArticle

  340. CARB 22-GPI anchors: WHY and HOW the complex molecules are being synthesized

    Nikolaev, A. V. 16 Aug 2009 In : Abstracts of Papers of the American Chemical Society. 238, p. - 1 p.

    Research output: Contribution to journalBook/Film/Article review

  341. Hit to lead and lead optimization of novel small molecules for the treatment of human African trypanosomiasis

    Freeman, J. C., Perales, J. B., Woodland, A., Bacchi, C. J., Bowling, T. S., Cleghorn, L., Gamon, C. G., Grimaldi, R., Hauser, D., Mercer, L. T., Nare, B., Nguyen, T. M., Noe, R. A., Rewerts, C. E., Wring, S. A., Wyatt, P. G., Yarlett, N. R., Jacobs, R. T. & Don, R. 16 Aug 2009 In : Abstracts of Papers of the American Chemical Society. 238, p. - 1 p.

    Research output: Contribution to journalBook/Film/Article review

  342. SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents

    Gigante, F., Kaiser, M., Brun, R. & Gilbert, I. H. 15 Aug 2009 In : Bioorganic & Medicinal Chemistry. 17, 16, p. 5950-5961 12 p.

    Research output: Contribution to journalArticle

  343. Casein kinase 1 isoform 2 is essential for bloodstream form Trypanosoma brucei

    Urbaniak, M. D. Aug 2009 In : Molecular and Biochemical Parasitology. 166, 2, p. 183-185 3 p.

    Research output: Contribution to journalArticle

  344. Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis

    Richardson, J. L., Nett, I. R. E., Jones, D. C., Abdille, M. H., Gilbert, I. H. & Fairlamb, A. H. Aug 2009 In : ChemMedChem. 4, 8, p. 1333-1340 8 p.

    Research output: Contribution to journalArticle

  345. Site-specific DNA double-strand breaks greatly increase stable transformation efficiency in Trypanosoma brucei

    Glover, L. & Horn, D. Aug 2009 In : Molecular and Biochemical Parasitology. 166, 2, p. 194-197 4 p.

    Research output: Contribution to journalArticle

  346. Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

    Patterson, S., Jones, D. C., Shanks, E. J., Frearson, J. A., Gilbert, I. H., Wyatt, P. G. & Fairlamb, A. H. Aug 2009 In : ChemMedChem. 4, 8, p. 1341-1353 13 p.

    Research output: Contribution to journalArticle

  347. What has DNA sequencing revealed about the VSG expression sites of African trypanosomes?

    McCulloch, R. & Horn, D. Aug 2009 In : Trends in Parasitology. 25, 8, p. 359-363 5 p.

    Research output: Contribution to journalScientific review

  348. One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

    Mpamhanga, C. P., Spinks, D., Tulloch, L. B., Shanks, E. J., Robinson, D. A., Collie, I. T., Fairlamb, A. H., Wyatt, P. G., Frearson, J. A., Hunter, W. N., Gilbert, I. H. & Brenk, R. 23 Jul 2009 In : Journal of Medicinal Chemistry. 52, 14, p. 4454-4465 12 p.

    Research output: Contribution to journalArticle

  349. Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

    Munoz, I. M., Hain, K., Declais, A-C., Gardiner, M., Toh, G. W., Sanchez-Pulido, L., Heuckmann, J. M., Toth, R., Macartney, T., Eppink, B., Kanaar, R., Ponting, C. P., Lilley, D. M. J. & Rouse, J. 10 Jul 2009 In : Molecular Cell. 35, 1, p. 116-127 12 p.

    Research output: Contribution to journalArticle

  350. A crowdsourcing evaluation of the NIH chemical probes

    Oprea, T. I., Bologa, C. G., Boyer, S., Curpan, R. F., Glen, R. C., Hopkins, A. L., Lipinski, C. A., Marshall, G. R., Martin, Y. C., Ostopovici-Halip, L., Rishton, G., Ursu, O., Vaz, R. J., Waller, C., Waldmann, H. & Sklar, L. A. Jul 2009 In : Nature Chemical Biology. 5, 7, p. 441-447 7 p.

    Research output: Contribution to journalArticle

  351. The phosphoproteome of bloodstream form Trypanosoma brucei, causative agent of African sleeping sickness

    Nett, I. R. E., Martin, D. M. A., Miranda-Saavedra, D., Lamont, D., Barber, J. D., Mehlert, A. & Ferguson, M. A. J. Jul 2009 In : Molecular & Cellular Proteomics. 8, 7, p. 1527-1538 12 p.

    Research output: Contribution to journalArticle

  352. The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat

    Large, C. H., Kalinichev, M., Lucas, A., Carignani, C., Bradford, A., Garbati, N., Sartori, I., Austin, N. E., Ruffo, A., Jones, D. N. C., Alvaro, G. & Read, K. D. Jul 2009 In : Epilepsy Research. 85, 1, p. 96-106 11 p.

    Research output: Contribution to journalArticle

  353. Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity

    Holloway, G. A., Charman, W. N., Fairlamb, A. H., Brun, R., Kaiser, M., Kostewicz, E., Novello, P. M., Parisot, J. P., Richardson, J., Street, I. P., Watson, K. G. & Baell, J. B. Jul 2009 In : Antimicrobial Agents and Chemotherapy. 53, 7, p. 2824-2833 10 p.

    Research output: Contribution to journalArticle

  354. Antigenic variation: extending the reach of telomeric silencing

    Horn, D. 23 Jun 2009 In : Current Biology. 19, 12, p. R496-R498 3 p.

    Research output: Contribution to journalEditorial

  355. Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

    Higgins, L. G., Kelleher, M. O., Eggleston, I. M., Itoh, K., Yamamoto, M. & Hayes, J. D. 15 Jun 2009 In : Toxicology and Applied Pharmacology. 237, 3, p. 267-280 14 p.

    Research output: Contribution to journalArticle

  356. GIcNAcstatins are nanomolar inhibitors of human O-GIcNAcase inducing cellular hyper-O-GIcNAcylation

    Dorfmueller, H. C., Borodkin, V. S., Schimpl, M. & van Aalten, D. M. F. 1 Jun 2009 In : Biochemical Journal. 420, p. 221-227 7 p.

    Research output: Contribution to journalArticle

  357. ATP and MO25 alpha regulate the conformational state of the STRAD alpha pseudokinase and activation of the LKB1 tumour suppressor

    Zeqiraj, E., Filippi, B. M., Goldie, S., Navratilova, I., Boudeau, J., Deak, M., Alessi, D. R. & van Aalten, D. M. F. Jun 2009 In : PLoS Biology. 7, 6, p. - 19 p.e1000126

    Research output: Contribution to journalArticle

  358. Structural and functional characterization of a putative polysaccharide deacetylase of the human parasite Encephalitozoon cuniculi

    Urch, J. E., Hurtado-Guerrero, R., Brosson, D., Liu, Z., Eijsink, V. G. H., Texier, C. & van Aalten, D. M. F. Jun 2009 In : Protein Science. 18, 6, p. 1197-1209 13 p.

    Research output: Contribution to journalArticle

  359. System-wide changes to SUMO modifications in response to heat shock

    Golebiowski, F., Matic, I., Tatham, M. H., Cole, C., Yin, Y., Nakamura, A., Cox, J., Barton, G. J., Mann, M. & Hay, R. T. 26 May 2009 In : Science Signaling. 2, 72, 12 p.ra24

    Research output: Contribution to journalArticle

  360. Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb

    Schmidt, K., Hughes, C., Chudek, J. A., Goodyear, S. R., Aspden, R. M., Talbot, R., Gundersen, T. E., Blomhoff, R., Henderson, C., Wolf, C. R. & Tickle, C. 15 May 2009 In : Molecular and Cellular Biology. 29, 10, p. 2716-2729 14 p.

    Research output: Contribution to journalArticle

  361. Jalview Version 2-a multiple sequence alignment editor and analysis workbench

    Waterhouse, A. M., Procter, J. B., Martin, D. M. A., Clamp, M. & Barton, G. J. 1 May 2009 In : BMC Bioinformatics. 25, 9, p. 1189-1191 3 p.

    Research output: Contribution to journalArticle

  362. Structure-based ligand design and the promise held for antiprotozoan drug discovery

    Hunter, W. N. 1 May 2009 In : Journal of Biological Chemistry. 284, 18, p. 11749-11753 5 p.

    Research output: Contribution to journalScientific review

  363. Geobacillus stearothermophilus 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate

    Cameron, S., Martini, V. P., Iulek, J. & Hunter, W. N. May 2009 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 65, p. 450-454 5 p.

    Research output: Contribution to journalArticle

  364. N-(2-hydroxypropyl)methacrylamide-amphotericin B (HPMA-AmB) copolymer conjugates as antileishmanial agents

    Nicoletti, S., Seifert, K. & Gilbert, I. H. May 2009 In : International Journal of Antimicrobial Agents. 33, 5, p. 441-448 8 p.

    Research output: Contribution to journalArticle

  365. A Structure-Based Approach to Ligand Discovery for 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase: A Target for Antimicrobial Therapy

    Ramsden, N. L., Buetow, L., Dawson, A., Kemp, L. A., Ulaganathan, V., Brenk, R., Klebe, G. & Hunter, W. N. 23 Apr 2009 In : Journal of Medicinal Chemistry. 52, 8, p. 2531-2542 12 p.

    Research output: Contribution to journalArticle

  366. GPIomics: global analysis of glycosylphosphatidylinositol-anchored molecules of Trypanosoma cruzi

    Nakayasu, E. S., Yashunsky, D. V., Nohara, L. L., Torrecilhas, A. C. T., Nikolaev, A. V. & Almeida, I. C. Apr 2009 In : Molecular Systems Biology. 5, 17 p.261

    Research output: Contribution to journalArticle

  367. Identification and specific localization of tyrosine-phosphorylated proteins in Trypanosoma brucei

    Nett, I. R. E., Davidson, L., Lamont, D. & Ferguson, M. A. J. Apr 2009 In : Eukaryotic Cell. 8, 4, p. 617-626 10 p.

    Research output: Contribution to journalArticle

  368. Receptor occupancy and brain free fraction

    Watson, J., Wright, S., Lucas, A., Clarke, K. L., Viggers, J., Cheetham, S., Jeffrey, P., Porter, R. & Read, K. D. Apr 2009 In : Drug Metabolism and Disposition. 37, 4, p. 753-760 8 p.

    Research output: Contribution to journalArticle

  369. Development of a Novel Virtual Screening Cascade Protocol to Identify Potential Trypanothione Reductase Inhibitors

    Perez-Pineiro, R., Burgos, A., Jones, D. C., Andrew, L. C., Rodriguez, H., Suarez, M., Fairlamb, A. H. & Wishart, D. S. 26 Mar 2009 In : Journal of Medicinal Chemistry. 52, 6, p. 1670-1680 11 p.

    Research output: Contribution to journalArticle

  370. Targeted delivery of compounds to Trypanosoma brucei using the melamine motif

    Chollet, C., Baliani, A., Wong, P. E., Barrett, M. P. & Gilbert, I. H. 15 Mar 2009 In : Bioorganic & Medicinal Chemistry. 17, 6, p. 2512-2523 12 p.

    Research output: Contribution to journalArticle

  371. Biochemistry: The evolution of ribozyme chemistry

    Wilson, T. J. & Lilley, D. M. J. 13 Mar 2009 In : Science. 323, 5920, p. 1436-1438 3 p.

    Research output: Contribution to journalArticle

  372. Trypanosoma brucei UDP-glucose:glycoprotein glucosyltransferase has unusual substrate specificity and protects the parasite from stress

    Izquierdo, L., Atrih, A., Rodrigues, J. A., Jones, D. C. & Ferguson, M. A. J. Feb 2009 In : Eukaryotic Cell. 8, 2, p. 230-240 11 p.

    Research output: Contribution to journalArticle

  373. Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase

    McCarthy, O., Musso-Buendia, A., Kaiser, M., Brun, R., Ruiz-Perez, L. M., Johansson, N. G., Pacanowska, D. G. & Gilbert, I. H. Feb 2009 In : European Journal of Medicinal Chemistry. 44, 2, p. 678-688 11 p.

    Research output: Contribution to journalArticle

  374. Nucleosomes can invade DNA territories occupied by their neighbors

    Engeholm, M., de Jager, M., Flaus, A., Brenk, R., van Noort, J. & Owen-Hughes, T. Feb 2009 In : Nature Structural & Molecular Biology. 16, 2, p. 151-158 8 p.

    Research output: Contribution to journalArticle

  375. The Glycogen-Binding Domain on the AMPK β Subunit Allows the Kinase to Act as a Glycogen Sensor

    McBride, A., Ghilagaber, S., Nikolaev, A. & Hardie, D. G. 7 Jan 2009 In : Cell Metabolism. 9, 1, p. 23-34 12 p.

    Research output: Contribution to journalArticle

  376. In vivo imaging of mammalian cells: cell engineering and viability

    Swedlow, J. R., Andrews, P. D. & Platani, M. 1 Jan 2009 In : Cold Spring Harbor Protocols. 4, 9

    Research output: Contribution to journalArticle

  377. In vivo imaging of mammalian cells: image acquisition and analysis

    Swedlow, J. R., Andrews, P. D. & Platani, M. 1 Jan 2009 In : Cold Spring Harbor Protocols. 4, 9

    Research output: Contribution to journalArticle

  378. Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni

    Musso-Buendía, J. A., Vidal, A. E., Carrero-Lérida, J., Ruiz-Pérez, L. M., González-Pacanowska, D., Kasinthan, G., Nguyen, C., Gilbert, I. H., Johansson, N. G. & Wilson, K. 1 Jan 2009 In : Journal of Enzyme Inhibition and Medicinal Chemistry. 24, 1, p. 111-116 6 p.

    Research output: Contribution to journalArticle

  379. A comparative study of methylglyoxal metabolism in trypanosomatids

    Greig, N., Wyllie, S., Patterson, S. & Fairlamb, A. H. Jan 2009 In : FEBS Journal. 276, 2, p. 376-386 11 p.

    Research output: Contribution to journalArticle

  380. Identification of a glycosylphosphatidylinositol anchor-modifying beta 1-3 N-acetylglucosaminyl transferase in Trypanosoma brucei

    Izquierdo, L., Nakanishi, M., Mehlert, A., Machray, G., Barton, G. J. & Ferguson, M. A. J. Jan 2009 In : Molecular Microbiology. 71, 2, p. 478-491 14 p.

    Research output: Contribution to journalArticle

  381. PIPs: human protein-protein interaction prediction database

    McDowall, M. D., Scott, M. S. & Barton, G. J. Jan 2009 In : Nucleic Acids Research. 37, Suppl 1, p. D651-D656 6 p.

    Research output: Contribution to journalArticle

  382. Streptococcus mutans SMU.623c codes for a functional, metal-dependent polysaccharide deacetylase that modulates interactions with salivary agglutinin

    Deng, D. M., Urch, J. E., ten Cate, J. M., Rao, V. A., van Aalten, D. M. F. & Crielaard, W. Jan 2009 In : Journal of Bacteriology. 191, 1, p. 394-402 9 p.

    Research output: Contribution to journalArticle

  383. Diversity oriented syntheses of fused pyrimidines designed as potential antifolates

    Gibson, C. L., Huggan, J. K., Kennedy, A., Kiefer, L., Lee, J. H., Suckling, C. J., Clements, C., Harvey, A. L., Hunter, W. N. & Tulloch, L. B. 2009 In : Organic and Biomolecular Chemistry. 7, 9, p. 1829-1842 14 p.

    Research output: Contribution to journalArticle

  384. DNA breaks as triggers for antigenic variation in African trypanosomes

    Alsford, S., Horn, D. & Glover, L. 2009 In : Genome Biology. 10, 6, 4 p.ARTN 223

    Research output: Contribution to journalScientific review

  385. Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity

    Howard, S. , Berdini, V. , Boulstridge, J. A. , Carr, M. G. , Cross, D. M. , Curry, J. , Devine, L. A. , Early, T. R. , Fazal, L. , Gill, A. L. , Heathcote, M. , Maman, S. , Matthews, J. E. , McMenamin, R. L. , Navarro, E. F. , O'Brien, M. A. , O'Reilly, M. , Rees, D. C. , Reule, M. , Tisi, D. & 3 others Williams, G., Vinković, M. & Wyatt, P. G. 2009 In : Journal of Medicinal Chemistry. 52, 2, p. 379-88 10 p.

    Research output: Contribution to journalArticle

  386. Fragment-based drug discovery in academia: Experiences from a tuberculosis programme

    Heikkila, T. J., Surade, S., Silvestre, H. L., Dias, M. V. B., Blundell, T. L., Ciulli, A., Bromfield, K., Scott, D., Howard, N., Wen, S., Wei, A. H., Osborne, D. & Abell, C. 2009 From Molecules to Medicines: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism. Sussman, J. L. & Spadon, P. (eds.). Springer Netherlands, p. 21-36 16 p. (NATO Science for Peace and Security Series A: Chemistry and Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  387. Glycosylphosphatidylinositol anchors

    Ferguson, M. A. J., Kinoshita, T. & Hart, G. W. 2009 Essentials of glycobiology. Varki, A. (ed.). 2nd ed. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, p. 143-162 20 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  388. How does human O-Glcnacase recognize O-Glcnacylated protein substrates?

    Schimpl, M., Borodkin, V. S. & Van Aalten, D. M. F. 2009 In : Glycobiology. 19, 11, p. 1369-1369 1 p.272

    Research output: Contribution to journalMeeting abstract

  389. Identification of nucleolar associated chromatin loci reveals clues for nuclear architecture

    van Koningsbruggen, S., Martin, D. M. A., Ariyurek, Y., den Dunnen, J. T. & Lamond, A. I. 2009 In : Cellular Oncology. 31, 2, p. 105-106 2 p.O16

    Research output: Contribution to journalBook/Film/Article review

  390. Kinomer v. 1.0: a database of systematically classified eukaryotic protein kinases

    Martin, D. M. A., Miranda-Saavedra, D. & Barton, G. J. 2009 In : Nucleic Acids Research. 37, Suppl. 1. Database issue, p. D244-D250 7 p.

    Research output: Contribution to journalArticle

  391. Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites

    Baliani, A., Peal, V., Gros, L., Brun, R., Kaiser, M., Barrett, M. P. & Gilbert, I. H. 2009 In : Organic and Biomolecular Chemistry. 7, 6, p. 1154-1166 13 p.

    Research output: Contribution to journalArticle

  392. Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold

    Dixon, M. J., Nathubhai, A., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M. 2009 In : Organic and Biomolecular Chemistry. 7, 2, p. 259-268 10 p.

    Research output: Contribution to journalArticle

  393. Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide

    Fyfe, P. K., Rao, V. A., Zemla, A., Cameron, S. & Hunter, W. N. 2009 In : Angewandte Chemie International Edition. 48, 48, p. 9176-9179 4 p.

    Research output: Contribution to journalArticle

  394. SPPS of the natural product chitinase inhibitor argifin: library generation and biological evaluation

    Dixon, M. J., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M. 2009 Peptides for youth: the proceedings of the 20th American Peptide Symposium. Del Valle, S., Escher, E. & Lubell, W. D. (eds.). New York: Springer, p. 143-144 2 p. (Advances in experimental medicine and biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  395. Synthesis and structure-based dissection of cyclic peptide chitinase inhibitors: new leads for antifungal and anti-inflammatory drugs

    Dixon, M. J., Nathubhai, A., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M. 2009 Peptides for youth: the proceedings of the 20th American Peptide Symposium. Del Valle, S., Escher, E. & Lubell, W. D. (eds.). New York: Springer, p. 525-526 2 p. (Advances in experimental medicine and biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  396. The GlcNAc-PI de-N-acetylase: structure, function, and activity

    Urbaniak, M. D. & Ferguson, M. A. J. 2009 In : Enzymes. 26, p. 49-64 16 p.

    Research output: Contribution to journalArticle

  397. Specificity and reactivity in menaquinone biosynthesis: the structure of Escherichia coli MenD (2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase)

    Dawson, A., Fyfe, P. K. & Hunter, W. N. 31 Dec 2008 In : Journal of Molecular Biology. 384, 5, p. 1353-1368 16 p.

    Research output: Contribution to journalArticle

  398. Inhibitors of tubulin assembly identified through screening a compound library

    Morgan, R. E., Ahn, S., Nzimiro, S., Fotie, J., Phelps, M. A., Cotrill, J., Yakovich, A. J., Sackett, D. L., Dalton, J. T. & Werbovetz, K. A. Dec 2008 In : Chemical Biology & Drug Design. 72, 6, p. 513-524 12 p.

    Research output: Contribution to journalArticle

  399. Structure of the OSR1 kinase, a hypertension drug target

    Villa, F., Deak, M., Alessi, D. R. & van Aalten, D. M. F. Dec 2008 In : Proteins: Structure, Function, and Bioinformatics. 73, 4, p. 1082-1087 6 p.

    Research output: Contribution to journalArticle

  400. A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

    Towler, M. C., Fogarty, S., Hawley, S. A., Pan, D. A., Martin, D. M. A., Morrice, N. A., McCarthy, A., Galardo, M. N., Meroni, S. B., Cigorraga, S. B., Ashworth, A., Sakamoto, K. & Hardie, D. G. 15 Nov 2008 In : Biochemical Journal. 416, 1, p. 1-14 14 p.

    Research output: Contribution to journalArticle

  401. Structure of staphylococcus aureus EsxA suggests a contribution to virulence by action as a transport chaperone and/or adaptor protein

    Sundaramoorthy, R., Fyfe, P. K. & Hunter, W. N. 14 Nov 2008 In : Journal of Molecular Biology. 383, 3, p. 603-614 12 p.

    Research output: Contribution to journalArticle

  402. Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.

    Ciulli, A., Scott, D. E., Ando, M., Reyes, F., Saldanha, S. A., Tuck, K. L., Chirgadze, D. Y., Blundell, T. L. & Abell, C. 3 Nov 2008 In : ChemBioChem. 9, 16, p. 2606-2611 6 p.

    Research output: Contribution to journalArticle

  403. ATP-dependent ligases in trypanothione biosynthesis - kinetics of catalysis and inhibition by phosphinic acid pseudopeptides

    Oza, S. L., Chen, S., Wyllie, S., Coward, J. K. & Fairlamb, A. H. Nov 2008 In : FEBS Journal. 275, 21, p. 5408-5421 14 p.

    Research output: Contribution to journalArticle

  404. GPIomics: Global Analysis of Glycosylphosphatidylinositol (GPI)-Anchored Molecules of Trypanosoma cruzi by Tandem Mass Spectrometry

    Nakayasu, E. S., Yashunsky, D. V., Nohara, L. L., Torrecilhas, A. C. T., Nikolaev, A. V. & Almeida, I. C. Nov 2008 In : Glycobiology. 18, 11, p. 974-974 1 p.140

    Research output: Contribution to journalBook/Film/Article review

  405. Network pharmacology: the next paradigm in drug discovery

    Hopkins, A. L. Nov 2008 In : Nature Chemical Biology. 4, 11, p. 682-690 9 p.

    Research output: Contribution to journalScientific review

  406. Sugar nucleotide metabolism and compartmentation in Trypanosoma brucei: new insights from UDP-GlcNAc and UDP-Glc biosynthesis

    Marino, K., Guther, M. L. S. & Ferguson, M. Nov 2008 In : Glycobiology. 18, 11, p. 946-946 1 p.

    Research output: Contribution to journalMeeting abstract

  407. Synthesis and testing of peptides for anti-prion activity

    Sellarajah, S., Boussard, C., Lekishvili, T., Brown, D. R. & Gilbert, I. H. Nov 2008 In : European Journal of Medicinal Chemistry. 43, 11, p. 2418-2427 10 p.

    Research output: Contribution to journalArticle

  408. Structural insights into mechanism and specificity of O-GlcNAc transferase

    Clarke, A. J., Hurtado-Guerrero, R., Pathak, S., Schuettelkopf, A., Borodkin, V., Shepherd, S. M., Ibrahim, A. F. M. & van Aalten, D. M. F. 22 Oct 2008 In : EMBO Journal. 27, 20, p. 2780-2788 9 p.

    Research output: Contribution to journalArticle

  409. Identification and characterization of FUS/TLS as a new target of ATM

    Gardiner, M., Toth, R., Vandermoere, F., Morrice, N. A. & Rouse, J. 15 Oct 2008 In : Biochemical Journal. 415, p. 297-307 11 p.

    Research output: Contribution to journalArticle

  410. Evolution of the multivesicular body ESCRT machinery: retention across the eukaryotic lineage

    Leung, K. F., Dacks, J. B. & Field, M. C. Oct 2008 In : Traffic. 9, 10, p. 1698-1716 19 p.

    Research output: Contribution to journalArticle

  411. Molecular mechanisms of O-GlcNAcylation

    Hurtado-Guerrero, R., Dorfmueller, H. C. & van Aalten, D. M. F. Oct 2008 In : Current Opinion in Structural Biology. 18, 5, p. 551-557

    Research output: Contribution to journalArticle

  412. Probing Enzymes Late in the Trypanosomal Glycosylphosphatidylinositol Biosynthetic Pathway with Synthetic Glycosylphosphatidylinositol Analogues

    Urbaniak, M. D., Yashunsky, D. V., Crossman, A., Nikolaev, A. V. & Ferguson, M. A. J. Oct 2008 In : ACS Chemical Biology. 3, 10, p. 625-634 10 p.

    Research output: Contribution to journalArticle

  413. Putting glycobiology on a structural footing

    van Aalten, D. M. F. & Strynadka, N. C. J. Oct 2008 In : Current Opinion in Structural Biology. 18, 5, p. 525-526 2 p.

    Research output: Contribution to journalEditorial

  414. A new family of transcription factors

    Yamada, Y., Wang, H-Y., Fukuzawa, M., Barton, G. J. & Williams, J. G. 15 Sep 2008 In : Development. 135, 18, p. 3093-3101 9 p.

    Research output: Contribution to journalArticle

  415. Structural and mechanistic insights into type II trypanosomatid tryparedoxin-dependent peroxidases

    Alphey, M. S., Konig, J. & Fairlamb, A. H. 15 Sep 2008 In : Biochemical Journal. 414, 3, p. 375-381 7 p.

    Research output: Contribution to journalArticle

  416. Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands

    Fang, J., Akwabi-Ameyaw, A., Britton, J. E., Katamreddy, S. R., Navas III, F., Miller, A. B., Williams, S. P., Gray, D. W., Orband-Miller, L. A., Shearin, J. & Heyer, D. 15 Sep 2008 In : Bioorganic & Medicinal Chemistry Letters. 18, 18, p. 5075-5077 3 p.

    Research output: Contribution to journalArticle

  417. Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei

    Alsford, S. & Horn, D. Sep 2008 In : Molecular and Biochemical Parasitology. 161, 1, p. 76-79 4 p.

    Research output: Contribution to journalArticle

  418. Phosphatidylethanolamine in Trypanosoma brucei is organized in two separate pools and is synthesized exclusively by the Kennedy pathway

    Signorell, A., Rauch, M., Jelk, J., Ferguson, M. A. J. & Buetikofer, P. 29 Aug 2008 In : Journal of Biological Chemistry. 283, 35, p. 23636-23644 9 p.

    Research output: Contribution to journalArticle

  419. Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design

    Wyatt, P. G. , Woodhead, A. J. , Berdini, V. , Boulstridge, J. A. , Carr, M. G. , Cross, D. M. , Davis, D. J. , Devine, L. A. , Early, T. R. , Feltell, R. E. , Lewis, E. J. , McMenamin, R. L. , Navarro, E. F. , O'Brien, M. A. , O'Reilly, M. , Reule, M. , Saxty, G. , Seavers, L. C. A. , Smith, D-M. , Squires, M. S. & 3 others Trewartha, G., Walker, M. T. & Woolford, A. J. -A. 28 Aug 2008 In : Journal of Medicinal Chemistry. 51, 16, p. 4986-4999 14 p.

    Research output: Contribution to journalArticle

  420. Chemical dissection of the link between streptozotocin, O-GlcNAc, and pancreatic cell death

    Pathak, S., Dorfmueller, H. C., Borodkin, V. S. & van Aalten, D. M. F. 25 Aug 2008 In : Chemistry & Biology. 15, 8, p. 799-807 9 p.

    Research output: Contribution to journalArticle

  421. COMP 90-The trouble with translating information into medicines: strategies for embracing serendipity and uncertainty

    Hopkins, A. L. 17 Aug 2008 In : Abstracts of Papers of the American Chemical Society. 236, p. - 1 p.

    Research output: Contribution to journalBook/Film/Article review

  422. Probing Trypanosoma brucei glycosylphosphatidylinositol biosynthesis using novel precursor-analogues

    Urbaniak, M. D., Crossman, A. & Ferguson, M. A. J. Aug 2008 In : Chemical Biology & Drug Design. 72, 2, p. 127-132 6 p.

    Research output: Contribution to journalArticle

  423. Synthesis of cyclic peptide chitinase inhibitors: natural products,with chemotherapeutic potential

    Dixon, M., Nathubhai, A., Andersen, O., van Aalten, D. & Eggleston, I. Aug 2008 In : Journal of Peptide Science. 14, S1, p. 13-13 1 p.S02-4

    Research output: Contribution to journalBook/Film/Article review

  424. Synthetic approaches to cyclic peptide natural products as chitinase inhibitors

    Dixon, M., Giuntini, F., Nathubhai, A., Andersen, O., van Aalten, D. & Eggleston, I. Aug 2008 In : Journal of Peptide Science. 14, S1, p. 55-55 1 p.P10102-031

    Research output: Contribution to journalBook/Film/Article review

  425. Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes

    Kawahara, T., Siegel, T. N., Ingram, A. K., Alsford, S., Cross, G. A. M. & Horn, D. Aug 2008 In : Molecular Microbiology. 69, 4, p. 1054-1068 15 p.

    Research output: Contribution to journalArticle

  426. Synergistic inhibition of ErbB signaling by combined treatment with seliciclib and ErbB-targeting agents

    Fleming, I. N., Hogben, M., Frame, S., McClue, S. J. & Green, S. R. 1 Jul 2008 In : Clinical Cancer Research. 14, 13, p. 4326-35 10 p.

    Research output: Contribution to journalArticle

  427. Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes

    Sienkiewicz, N., Jaroslawski, S., Wyllie, S. & Fairlamb, A. H. Jul 2008 In : Molecular Microbiology. 69, 2, p. 520-533 14 p.

    Research output: Contribution to journalArticle

  428. Evaluation of direct transport pathways of glycine receptor antagonists and an angiotensin antagonist from the nasal cavity to the central nervous system in the rat model

    Charlton, S. T., Whetstone, J., Fayinka, S. T., Read, K. D., Illum, L. & Davis, S. S. Jul 2008 In : Pharmaceutical Research. 25, 7, p. 1531-1543 13 p.

    Research output: Contribution to journalArticle

  429. SCANPS: a web server for iterative protein sequence database searching by dynamic programing, with display in a hierarchical SCOP browser

    Walsh, T. P., Webber, C., Searle, S., Sturrock, S. S. & Barton, G. J. Jul 2008 In : Nucleic Acids Research. 36, p. W25-W29 5 p.

    Research output: Contribution to journalArticle

  430. TarO: a target optimisation system for structural biology

    Overton, I. M., van Niekerk, C. A. J., Carter, L. G., Dawson, A., Martin, D. M. A., Cameron, S., McMahon, S. A., White, M. F., Hunter, W. N., Naismith, J. H. & Barton, G. J. Jul 2008 In : Nucleic Acids Research. 36, p. W190-W196 7 p.

    Research output: Contribution to journalArticle

  431. The Jpred 3 secondary structure prediction server

    Cole, C., Barber, J. D. & Barton, G. J. Jul 2008 In : Nucleic Acids Research. 36, S2, p. W197-W201 5 p.

    Research output: Contribution to journalArticle

  432. Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities

    Fyfe, P. K., Oza, S. L., Fairlamb, A. H. & Hunter, W. N. 20 Jun 2008 In : Journal of Biological Chemistry. 283, 25, p. 17672-17680 9 p.

    Research output: Contribution to journalArticle

  433. The synthesis of UDP-N-acetylglucosamine is essential for bloodstream form Trypanosoma brucei in vitro and in vivo and UDP-N-acetylglucosamine starvation reveals a hierarchy in parasite protein glycosylation

    Stokes, M. J., Guther, M. L. S., Turnock, D. C., Prescott, A. R., Martin, K. L., Alphey, M. S. & Ferguson, M. A. J. 6 Jun 2008 In : Journal of Biological Chemistry. 283, 23, p. 16147-16161 15 p.

    Research output: Contribution to journalArticle

  434. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

    Huang, X., Wullschleger, S., Shpiro, N., McGuire, V. A., Sakamoto, K., Woods, Y. L., McBurnie, W., Fleming, S. & Alessi, D. R. 1 Jun 2008 In : Biochemical Journal. 412, p. 211-221 11 p.

    Research output: Contribution to journalArticle

  435. Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-D-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery

    Sgraja, T., Alphey, M. S., Ghilagaber, S., Marquez, R., Robertson, M. N., Hemmings, J. L., Lauw, S., Rohdich, F., Bacher, A., Eisenreich, W., Illarionova, V. & Hunter, W. N. Jun 2008 In : FEBS Journal. 275, 11, p. 2779-2794 16 p.

    Research output: Contribution to journalArticle

  436. Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes

    Glover, L., McCulloch, R. & Horn, D. Jun 2008 In : Nucleic Acids Research. 36, 8, p. 2608-2618 11 p.

    Research output: Contribution to journalArticle

  437. Targetes gene regulation mediated by nucleolar snoRNAs

    Ono, M., Scott, M., Yamada, K., Barton, G., Hutvagner, G. & Lamond, A. Jun 2008 In : FEBS Journal. 275, S1, p. 73-73 1 p.

    Research output: Contribution to journalBook/Film/Article review

  438. Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer

    McCracken, S. R. C., Ramsay, A., Heer, R., Mathers, M. E., Jenkins, B. L., Edwards, J., Robson, C. N., Marquez, R., Cohen, P. & Leung, H. Y. 8 May 2008 In : Oncogene. 27, 21, p. 2978-2988 11 p.

    Research output: Contribution to journalArticle

  439. Deletion of the TbALG3 gene demonstrates site-specific N-glycosylation and N-glycan processing in Trypanosoma brucei

    Manthri, S., Guther, M. L. S., Izquierdo, L., Acosta-Serrano, A. & Ferguson, M. A. J. May 2008 In : Glycobiology. 18, 5, p. 367-383 17 p.

    Research output: Contribution to journalArticle

  440. Genome analysis of the unicellular green alga Chlamydomonas reinhardtii indicates an ancient evolutionary origin for key pattern recognition and cell-signaling protein families

    Wheeler, G. L., Miranda-Saavedra, D. & Barton, G. J. May 2008 In : Genetics. 179, 1, p. 193-197 5 p.

    Research output: Contribution to journalArticle

  441. The cancer chemopreventive actions of phytochemicals derived from glucosinolates

    Hayes, J. D., Kelleher, M. O. & Eggleston, I. M. May 2008 In : European Journal of Nutrition. 47, p. 73-88 16 p.

    Research output: Contribution to journalScientific review

  442. A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

    Wilkinson, S. R., Taylor, M. C., Horn, D., Kelly, J. M. & Cheeseman, I. 1 Apr 2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 13, p. 5022-5027 6 p.

    Research output: Contribution to journalArticle

  443. ParCrys: a Parzen window density estimation approach to protein crystallization propensity prediction

    Overton, I. M., Padovani, G., Girolami, M. A. & Barton, G. J. 1 Apr 2008 In : BMC Bioinformatics. 24, 7, p. 901-907 7 p.

    Research output: Contribution to journalArticle

  444. Crystal structures of Toxoplasma gondii pterin-4a-carbinolamine dehydratase and comparisons with mammalian and parasite orthologues

    Cameron, S., Fyffe, S. A., Goldie, S. & Hunter, W. N. Apr 2008 In : Molecular and Biochemical Parasitology. 158, 2, p. 131-138 8 p.

    Research output: Contribution to journalArticle

  445. GPIs on a chip

    Ferguson, M. A. J. Apr 2008 In : Nature Chemical Biology. 4, 4, p. 223-224 2 p.

    Research output: Contribution to journalComment/debate

  446. Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials

    Wyllie, S., Vickers, T. J. & Fairlamb, A. H. Apr 2008 In : Antimicrobial Agents and Chemotherapy. 52, 4, p. 1359-1365 7 p.

    Research output: Contribution to journalArticle

  447. Lessons learnt from assembling screening libraries for drug discovery for neglected diseases

    Brenk, R., Schipani, A., James, D., Krasowski, A., Gilbert, I. H., Frearson, J. & Wyatt, P. G. Mar 2008 In : ChemMedChem. 3, 3, p. 435-444 10 p.

    Research output: Contribution to journalArticle

  448. Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin

    Andersen, O. A., Nathubhai, A., Dixon, M. J., Eggleston, I. M. & van Aalten, D. M. F. Mar 2008 In : Chemistry & Biology. 15, 3, p. 295-301 7 p.

    Research output: Contribution to journalArticle

  449. Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

    Cavazzuti, A., Paglietti, G., Hunter, W. N., Gamarro, F., Piras, S., Loriga, M., Alleca, S., Corona, P., McLuskey, K., Tulloch, L., Gibellini, F., Ferrari, S. & Costin, M. P. 5 Feb 2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 5, p. 1448-1453 6 p.

    Research output: Contribution to journalArticle

  450. Acetylation of histone H4K4 is cell cycle regulated and mediated by HAT3 in Trypanosoma brucei

    Siegel, T. N., Kawahara, T., DeGrasse, J. A., Janzen, C. J., Horn, D. & Cross, G. A. M. Feb 2008 In : Molecular Microbiology. 67, 4, p. 762-771 10 p.

    Research output: Contribution to journalArticle

  451. The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction

    Manning, J. R., Jefferson, E. R. & Barton, G. J. 25 Jan 2008 In : BMC Bioinformatics. 9, p. - 16 p.51

    Research output: Contribution to journalArticle

  452. Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids

    Horn, D. 3 Jan 2008 In : BMC Genomics. 9, 2, 11 p.ARTN 2

    Research output: Contribution to journalArticle

  453. A comparison of SCOP and CATH with respect to domain-domain interactions

    Jefferson, E. R., Walsh, T. P. & Barton, G. J. Jan 2008 In : Proteins: Structure, Function, and Bioinformatics. 70, 1, p. 54-62 9 p.

    Research output: Contribution to journalArticle

  454. Sequence alignment for molecular replacement

    Barton, G. J. Jan 2008 In : Acta Crystallographica Section D: Biological Crystallography. 64, p. 25-32 8 p.

    Research output: Contribution to journalArticle

  455. Analysis of small GTPase function in trypanosomes

    Field, M. C., Horn, D. & Carrington, M. 2008 Small GTPases in disease. Part A. Balch, W., Der, C. J. & Hall, A. (eds.). Amsterdam: Academic Press, p. 57-76 20 p. (Methods in Enzymology).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  456. Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases

    Gibellini, F., Hunter, W. N. & Smith, T. K. 2008 In : Biochemical Journal. 415, p. 135-144 10 p.

    Research output: Contribution to journalArticle

  457. Dual-specificity phosphatases in the hypo-osmotic stress response of keratin-defective epithelial cell lines

    Liovic, M., Lee, B., Tomic-Canic, M., D'Alessandro, M., Bolshakov, V. N. & Lane, E. B. 2008 In : Experimental Cell Research. 314, 10, p. 2066-2075 10 p.

    Research output: Contribution to journalArticle

  458. Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham.

    Gallo, M. B. C., Marques, A. S. F., Vieira, P. C., da Silva, M. F. D. G. F., Fernandes, J. B., Silva, M., Guido, R. V., Oliva, G., Thiemann, O. H., Albuquerque, S. & Fairlamb, A. H. 2008 In : Zeitschrift für Naturforschung C: a Journal of Biosciences. 63, 5-6, p. 371-382 12 p.

    Research output: Contribution to journalArticle

  459. Evaluation of a head mounted camera for clinical dental teaching

    Chadwick, R. G., Carena, A. P., Hunter, B. & Campbell, K. 2008 In : British Dental Journal. 204, 2, p. 93-96 4 p.

    Research output: Contribution to journalArticle

  460. Genomic-scale prioritization of drug targets: the TDR Targets database

    Agüero, F. , Al-Lazikani, B. , Aslett, M. , Berriman, M. , Buckner, F. S. , Campbell, R. K. , Carmona, S. , Carruthers, I. M. , Chan, A. W. E. , Chen, F. , Crowther, G. J. , Doyle, M. A. , Hertz-Fowler, C. , Hopkins, A. L. , McAllister, G. , Nwaka, S. , Overington, J. P. , Pain, A. , Paolini, G. V. , Pieper, U. & 8 others Ralph, S. A., Riechers, A., Roos, D. S., Sali, A., Shanmugam, D., Suzuki, T., Van Voorhis, W. C. & Verlinde, C. L. M. J. 2008 In : Nature Reviews Drug Discovery. 7, 11, p. 900-907 8 p.

    Research output: Contribution to journalArticle

  461. Histone deacetylases

    Horn, D. 2008 Drug targets in kinetoplastid parasites. Majumder, H. K. (ed.). Berlin: Springer, p. 81-86 6 p. (Advances in experimental medicine and biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  462. Inequalities in access to education and healthcare

    Nunn, J., Freeman, R., Anderson, E., Carneiro, L. C., Carneiro, M. S. A., Formicola, A., Frezel, R., Kayitenkore, J., Luhanga, C., Molina, G., Morio, I., Nartey, N. O., Ngom, P. I., Navarro, M. F. D. L., Segura, A., Oliver, S., Thompson, S., Wandera, M. & Yazdanie, N. 2008 In : European Journal of Dental Education. 12, p. 30-39 10 p.

    Research output: Contribution to journalArticle

  463. Inhibition of trypanothione reductase and glutathione reductase by ferrocenic 4-aminoquinoline ureas

    Blackie, M. A. L., Saravanamuthu, A., Fairlamb, A. H. & Chibale, K. 2008 In : ARKIVOC. 2008, vi, p. 52-60 9 p.

    Research output: Contribution to journalArticle

  464. Inhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysis

    Hirsch, A. K. H., Alphey, M. S., Lauw, S., Seet, M., Barandun, L., Eisenreich, W., Rohdich, F., Hunter, W. N., Bacher, A. & Diederich, F. 2008 In : Organic and Biomolecular Chemistry. 6, 15, p. 2719-2730 12 p.

    Research output: Contribution to journalArticle

  465. Kinetoplastids: related protozoan pathogens, different diseases

    Stuart, K., Brun, R., Croft, S., Fairlamb, A., Guertler, R. E., McKerrow, J., Reed, S. & Tarleton, R. 2008 In : Journal of Clinical Investigation. 118, 4, p. 1301-1310 10 p.

    Research output: Contribution to journalScientific review

  466. Pharmacological space

    Hopkins, A. L. 2008 The practice of medicinal chemistry. Wermuth, C. G. (ed.). 3rd ed. London: Academic Press, p. 521-532 12 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  467. The importance of G center dot A hydrogen bonding in the metal ion- and protein-induced folding of a kink turn RNA

    Turner, B. & Lilley, D. M. J. 2008 In : Journal of Molecular Biology. 381, 2, p. 431-442 12 p.

    Research output: Contribution to journalArticle

  468. The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design

    Lucas-Lopez, C., Allingham, J. S., Lebl, T., Lawson, C. P. A. T., Brenk, R., Sellers, J. R., Rayment, I. & Westwood, N. J. 2008 In : Organic and Biomolecular Chemistry. 6, 12, p. 2076-2084 9 p.

    Research output: Contribution to journalArticle

  469. Toward an improved prediction of human in vivo brain penetration

    Summerfield, S. G., Lucas, A. J., Porter, R. A., Jeffrey, P., Gunn, R. N., Read, K. R., Stevens, A. J., Metcalf, A. C., Osuna-Cabello, M. C., Kilford, P. J., Passchier, J. & Ruffo, A. D. 2008 In : Xenobiotica. 38, 12, p. 1518-1535 18 p.

    Research output: Contribution to journalArticle

  470. The selectivity of protein kinase inhibitors: a further update

    Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., Mclauchlan, H., Klevernic, I., Arthur, J. S. C., Alessi, D. R. & Cohen, P. 15 Dec 2007 In : Biochemical Journal. 408, p. 297-315 19 p.

    Research output: Contribution to journalArticle

  471. Efficient synthesis of 1,3,7-substituted xanthines by a safety-catch protection strategy

    Allwood, M., Cannan, B., van Aalten, D. M. F. & Eggleston, I. M. 10 Dec 2007 In : Tetrahedron. 63, 50, p. 12294-12302 9 p.

    Research output: Contribution to journalArticle

  472. Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development

    Eoh, H., Brown, A. C., Buetow, L., Hunter, W. N., Parish, T., Kaur, D., Brennan, P. J. & Crick, D. C. Dec 2007 In : Journal of Bacteriology. 189, 24, p. 8922-8927 6 p.

    Research output: Contribution to journalArticle

  473. Micro-magnetic resonance imaging of avian embryos

    Li, X., Liu, J., Davey, M., Duce, S., Jaberi, N., Liu, G., Davidson, G., Tenent, S., Mahood, R., Brown, P., Cunningham, C., Bain, A., Beattie, K., McDonald, L., Schmidt, K., Towers, M., Tickle, C. & Chudek, S. Dec 2007 In : Journal of Anatomy. 211, 6, p. 798-809 12 p.

    Research output: Contribution to journalArticle

  474. Target assessment for antiparasitic drug discovery

    Frearson, J. A., Wyatt, P. G., Gilbert, I. H. & Fairlamb, A. H. Dec 2007 In : Trends in Parasitology. 23, 12, p. 589-595 7 p.

    Research output: Contribution to journalScientific review

  475. A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major

    König, J. & Fairlamb, A. H. Nov 2007 In : FEBS Journal. 274, 21, p. 5643-5658 16 p.

    Research output: Contribution to journalArticle

  476. Distance determination in heterogeneous DNA model systems by pulsed EPR

    Ward, R., Keeble, D. J., El-Mkami, H. & Norman, D. G. Nov 2007 In : ChemBioChem. 8, 16, p. 1957-1964 8 p.

    Research output: Contribution to journalArticle

  477. Picking pockets to fuel antimicrobial drug discovery

    Hunter, W. N. Nov 2007 In : Biochemical Society Transactions. 35, p. 980-984 5 p.

    Research output: Contribution to journalArticle

  478. Quinuclidine derivatives as potential antiparasitics

    Cammerer, S. B., Jimenez, C., Jones, S., Gros, L., Lorente, S. O., Rodrigues, C., Rodrigues, J. C. F., Caldera, A., Perez, L. M. R., da Souza, W., Kaiser, M., Brun, R., Urbina, J. A., Pacanowska, D. G. & Gilbert, I. H. Nov 2007 In : Antimicrobial Agents and Chemotherapy. 51, 11, p. 4049-4061 13 p.

    Research output: Contribution to journalArticle

  479. Structure of Staphylococcus aureus 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in complex with acetoacetyl-CoA

    Ulaganathan, V., Agacan, M. F., Buetow, L., Tulloch, L. B. & Hunter, W. N. Nov 2007 In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 63, p. 908-913 6 p.

    Research output: Contribution to journalArticle

  480. The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphatesynthase, an essential enzyme, provides a platform for drug discovery

    Buetow, L., Brown, A. C., Parish, T. & Hunter, W. N. 23 Oct 2007 In : BMC Structural Biology. 7, p. - 11 p.68

    Research output: Contribution to journalArticle

  481. Mechanistic insights into the cure of prion disease by novel antiprion compounds

    Webb, S., Lekishvili, T., Loeschner, C., Sellarajah, S., Prelli, F., Wisniewski, T., Gilbert, I. H. & Brown, D. R. Oct 2007 In : Journal of Virology. 81, 19, p. 10729-10741 13 p.

    Research output: Contribution to journalArticle

  482. The de novo synthesis of GDP-fucose is essential for flagellar adhesion and cell growth in trypanosoma brucei

    Turnock, D. C., Izquierdo, L. & Ferguson, M. A. J. Sep 2007 In : Journal of Biological Chemistry. 282, 39, p. 28853-28863 11 p.

    Research output: Contribution to journalArticle

  483. Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity

    Byres, E., Alphey, M. S., Smith, T. K. & Hunter, W. N. 10 Aug 2007 In : Journal of Molecular Biology. 371, 2, p. 540-553 14 p.

    Research output: Contribution to journalArticle

  484. Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major

    Turnock, D. C. & Ferguson, M. A. J. Aug 2007 In : Eukaryotic Cell. 6, 8, p. 1450-1463 14 p.

    Research output: Contribution to journalScientific review

  485. Synthesis and biological evaluation of phosphate Prodrugs of 4-Phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase

    Ruda, G. F., Alibu, V. P., Mitsos, C., Bidet, O., Kaiser, M., Brun, R., Barrett, M. P. & Gilbert, I. H. Aug 2007 In : ChemMedChem. 2, 8, p. 1169-1180 12 p.

    Research output: Contribution to journalArticle

  486. A chemo-genetic approach for the study of nucleobase participation in nucleolytic ribozymes

    Lilley, D. M. J. Jul 2007 In : Biological Chemistry. 388, 7, p. 699-704 6 p.

    Research output: Contribution to journalArticle

  487. Nucleotide substrate recognition by UDP-N-acetylglucosamine acyltransferase (LpxA) in the first step of lipid A biosynthesis

    Ulaganathan, V., Buetow, L. & Hunter, W. N. 1 Jun 2007 In : Journal of Molecular Biology. 369, 2, p. 305-312 8 p.

    Research output: Contribution to journalArticle

  488. Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives

    Sealey-Cardona, M., Cammerer, S., Jones, S., Ruiz-Perez, L. M., Brun, R., Gilbert, I. H., Urbina, J. A. & Gonzalez-Pacanowska, D. Jun 2007 In : Antimicrobial Agents and Chemotherapy. 51, 6, p. 2123-2129 7 p.

    Research output: Contribution to journalArticle

  489. A guanine nucleobase important for catalysis by the VS ribozyme

    Wilson, T. J., McLeod, A. C. & Lilley, D. M. J. 16 May 2007 In : EMBO Journal. 26, 10, p. 2489-2500 12 p.

    Research output: Contribution to journalArticle

  490. Alterations on the growth and ultrastructure of Leishmania chagasi induced by squalene synthase inhibitors

    Granthon, A. C., Braga, M. V., Rodrigues, J. C. F., Cammerer, S., Lorente, S. O., Gilbert, I. H., Urbina, J. A. & de Souza, W. 15 May 2007 In : Veterinary Parasitology. 146, 1-2, p. 25-34 10 p.

    Research output: Contribution to journalArticle

  491. A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription

    Gorski, J. J., Pathak, S., Panov, K., Kasciukovic, T., Panova, T., Russell, J. & Zomerdijk, J. C. B. M. Mar 2007 In : The EMBO Journal. 26, 6, p. 1560-1568 9 p.

    Research output: Contribution to journalArticle

  492. Natural phosphoglycans containing glycosyl phosphate units: structural diversity and chemical synthesis

    Nikolaev, A. V., Botvinko, I. V. & Ross, A. J. 26 Feb 2007 In : Carbohydrate Research. 342, 3-4, p. 297-344 48 p.

    Research output: Contribution to journalArticle

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