Cell Signalling

The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P. 1-May-2013 In : Biochemical Journal. 451, 3, p. 427-437, 11 p.

Research output: Contribution to journal › Article

PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3-Apr-2013 In : EMBO Journal. 32, 7, p. 1008-22, 15 p.

Research output: Contribution to journal › Article

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

Ohta, A., Schumacher, F-R., Mehellou, Y., Johnson, C., Knebel, A., Macartney, T. J., Wood, N. T., Alessi, D. R. & Kurz, T. 1-Apr-2013 In : Biochemical Journal. 451, 1, p. 111-122, 12 p.

Research output: Contribution to journal › Article

The clinical significance of calcium-signalling pathways mediating human sperm hyperactivation

Alasmari, W., Barratt, C. L. R., Publicover, S. J., Whalley, K. M., Foster, E., Kay, V., Martins Da Silva, S. & Oxenham, S. K. Apr-2013 In : Human Reproduction. 28, 4, p. 866-876, 11 p.

Research output: Contribution to journal › Article

CSN-and CAND1-dependent remodelling of the budding yeast SCF complex

Zemla, A., Thomas, Y., Kedziora, S., Knebel, A., Wood, N. T., Rabut, G. & Kurz, T. 27-Mar-2013 In : Nature Communications. 4, 1641

Research output: Contribution to journal › Article

Obesity-Induced Insulin Resistance in Human Skeletal Muscle Is Characterised by Defective Activation of p42/p44 MAP Kinase

Ruiz-Alcaraz, A. J., Lipina, C., Petrie, J. R., Murphy, M. J., Morris, A. D., Sutherland, C. & Cuthbertson, D. J. 28-Feb-2013 In : PLoS ONE. 8, 2, e56928

Research output: Contribution to journal › Article

Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

Yao, C., Johnson, W. M., Gao, Y., Wang, W., Zhang, J., Deak, M., Alessi, D. R., Zhu, X., Mieyal, J. J., Roder, H., Wilson-Delfosse, A. L. & Chen, S. G. 15-Jan-2013 In : Human Molecular Genetics. 22, 2, p. 328-344, 17 p.

Research output: Contribution to journal › Article

PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway

Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15-Jan-2013 In : Journal of Immunology. 190, 2, p. 565-77, 13 p.

Research output: Contribution to journal › Article

Ca2+ signalling through CatSper and Ca2+ stores regulate different behaviours in human sperm

Alasmari, W., Costello, S., Correia, J., Oxenham, S. K., Morris, J., Fernandes, L., Ramalho Santos, J., Kirkman-Brown, J., Michelangeli, F., Publicover, S. & Barratt, C. L. R. 2013 In : Journal of Biological Chemistry.

Research output: Contribution to journal › Article