Cell Signalling & Immunology

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

Lizcano, J. M., Goransson, O., Toth, R., Deak, M., Morrice, N. A., Boudeau, J., Hawley, S., Udd, L., Makela, T. P., Hardie, D. G. & Alessi, D. R. Feb-2004 In : The EMBO Journal. 23, 4, p. 833-843, 11 p.

Research output: Contribution to journal › Article

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

Scott, J. W., Hawley, S. A., Green, K. A., Anis, M., Stewart, G., Scullion, G. A., Norman, D. G. & Hardie, D. G. 2004 In : Journal of Clinical Investigation. 113, 2, p. 274-284, 11 p.

Research output: Contribution to journal › Article

Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling

West, M., Wallin, R. P. A., Matthews, S., Svensson, H. G., Zaru, R., Ljunggren, H-G., Prescott, A. R. & Watts, C. 2004 In : Science. 305, 5687, p. 1153-1157, 5 p.

Research output: Contribution to journal › Article

H+/amino acid transporter 1 (PAT1) is the imino acid carrier: an intestinal nutrient/drug transporter in human and rat

Anderson, C. M. H., Grenade, D. S., Boll, M., Foltz, M., Wake, K. A., Kennedy, D. J., Munck, L. K., Miyauchi, S., Taylor, P. M., Campbell, F. C., Munck, B. G., Daniel, H., Ganapathy, V. & Thwaites, D. T. 2004 In : Gastroenterology. 127, 5, p. 1410-1422, 13 p.

Research output: Contribution to journal › Article

p14 arf promotes small ubiquitin-like modifier conjugation of Werners helicase

Woods, Y. L., Xirodimas, D. P., Prescott, A. R., Sparks, A., Lane, D. P. & Saville, M. K. 2004 In : Journal of Biological Chemistry. 279, 48, p. 50157-50166, 10 p.

Research output: Contribution to journal › Article

Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo

Thompson, A. M. & 23 others Spruce, B. A., Campbell, L. A., McTavish, N., Cooper, M. A., Appleyard, M. V. L., O'Neill, M., Howie, J., Samson, J., Watt, S., Murray, K., McLean, D., Leslie, N. R., Safrany, S. T., Ferguson, M. J., Peters, J. A., Prescott, A. R., Box, G., Hayes, A., Nutley, B., Raynaud, F., Downes, C. P., Lambert, J. J. & Eccles, S. 2004 In : Cancer Research. 64, 1, p. 4875-4886, 12 p.

Research output: Contribution to journal › Article

Deletion of the GPIdeAc gene alters the location and fate of glycosylphosphatidylinositol precursors in Trypanosoma brucei

Guther, M. L. S., Prescott, A. R. & Ferguson, M. A. J. 16-Dec-2003 In : Biochemistry. 42, 49, p. 14532-14540, 9 p.

Research output: Contribution to journal › Article

Redox regulation of PI 3-kinase signalling via inactivation of PTEN

Leslie, N., Bennett, D., Downes, P., Gray, A., Lindsay, Y. E. & Stewart, H. Oct-2003 In : EMBO Journal. 22, 20, p. 5501-5510, 10 p.

Research output: Contribution to journal › Article

Complexes between the LKB1 tumor suppressor, STRAD α/β and MO25 α/β are upstream kinases in the AMP-activated protein kinase cascade

Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Makela, T. P., Alessi, D. R. & Hardie, D. G. Sep-2003 In : Journal of Biology. 2, 4, p. 28, 1 p.

Research output: Contribution to journal › Article

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

Mora, A., Davies, A. M., Bertrand, L., Sharif, I., Budas, G. R., Jovanovic, S., Mouton, V., Kahn, C. R., Lucocq, J. M., Gray, G. A., Jovanovic, A. & Alessi, D. R. Sep-2003 In : The EMBO Journal. 22, 18, p. 4666-4676, 11 p.

Research output: Contribution to journal › Article