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Cell Signalling & Immunology

  1. AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

    Hardie, D. G. Apr 2015 In : Current Opinion in Cell Biology. 33, April, p. 1-7 7 p.

    Research output: Contribution to journalArticle

  2. Identification of caveolar resident proteins in ventricular myocytes using a quantitative proteomic approach: dynamic changes in caveolar composition following adrenoceptor activation

    Wypijewski, K. J., Tinti, M., Chen, W., Lamont, D., Ashford, M. L. J., Calaghan, S. C. & Fuller, W. Mar 2015 In : Molecular & Cellular Proteomics. 14, 3, p. 596-608 13 p.

    Research output: Contribution to journalArticle

  3. ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation

    Stone, E. L., Pepper, M., Katayama, C. D., Kerdiles, Y. M., Lai, C-Y., Emslie, E., Lin, Y. C., Yang, E., Goldrath, A. W., Li, M. O., Cantrell, D. A. & Hedrick, S. M. 17 Feb 2015 In : Immunity. 42, 2, p. 239-251 13 p.

    Research output: Contribution to journalArticle

  4. Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation

    Pirkmajer, S., Kulkarni, S. S., Tom, R. Z., Ross, F. A., Hawley, S. A., Hardie, D. G., Zierath, J. R. & Chibalin, A. V. Feb 2015 In : Diabetes. 64, 2, p. 360-369 10 p.

    Research output: Contribution to journalArticle

  5. Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis

    Karelina, K., Liu, Y., Alzate-Correa, D., Wheaton, K. L., Hoyt, K. R., Arthur, J. S. C. & Obrietan, K. 29 Jan 2015 In : Neuroscience. 285, p. 292-302 11 p.

    Research output: Contribution to journalArticle

  6. RAB1A promotes Vaccinia virus replication by facilitating the production of intracellular enveloped virions

    Pechenick Jowers, T., Featherstone, R. J., Reynolds, D. K., Brown, H. K., James, J., Prescott, A., Haga, I. R. & Beard, P. M. 15 Jan 2015 In : Virology. 475, p. 66-73 8 p.

    Research output: Contribution to journalArticle

  7. PTEN inhibitors: an evaluation of current compounds

    Spinelli, L., Lindsay, Y. E. & Leslie, N. R. Jan 2015 In : Advances in Biological Regulation. 57, p. 102-111 10 p.

    Research output: Contribution to journalArticle

  8. High-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow-derived macrophages

    Guo, M., Härtlova, A., Dill, B. D., Prescott, A. R., Gierliński, M. & Trost, M. 2015 In : Proteomics. 12 p.

    Research output: Contribution to journalArticle

  9. Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes

    Spinelli, L., Black, F. M., Berg, J. N., Eickholt, B. J. & Leslie, N. R. 19 Dec 2014 In : Journal of Medical Genetics.

    Research output: Contribution to journalArticle

  10. Substrate recognition by the cell surface palmitoyl transferase DHHC5

    Howie, J., Reilly, L., Fraser, N. J., Vlachaki Walker, J., Wypijewski, . K. J., Ashford, M. L. J., Calaghan, S., McClafferty, H., Tian, L., Shipston, M. J., Boguslavskyi, A., Shattock, M. J. & Fuller, W. 9 Dec 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 49, p. 17534-17539 6 p.

    Research output: Contribution to journalArticle

  11. AMPK-sensing energy while talking to other signaling pathways

    Hardie, D. G. 2 Dec 2014 In : Cell Metabolism. 20, 6, p. 939-952 14 p.

    Research output: Contribution to journalArticle

  12. AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

    Hardie, D. G. Dec 2014 In : Journal of Internal Medicine. 276, 6, p. 543-559 17 p.

    Research output: Contribution to journalArticle

  13. Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks

    Navarro, M. N., Goebel, J., Hukelmann, J. L. & Cantrell, D. A. Dec 2014 In : Molecular & Cellular Proteomics. 13, 12, p. 3544-3557 14 p.

    Research output: Contribution to journalArticle

  14. Pseudaminic acid on Campylobacter jejuni flagella modulates dendritic cell IL-10 expression via Siglec-10 receptor: a novel flagellin-host interaction

    Stephenson, H. N., Mills, D. C., Jones, H., Milioris, E., Copland, A., Dorrell, N., Wren, B. W., Crocker, P. R., Escors, D. & Bajaj-Elliott, M. 1 Nov 2014 In : Journal of Infectious Diseases. 210, 9, p. 1487-1498 12 p.

    Research output: Contribution to journalArticle

  15. Carnosic acid stimulates glucose uptake in skeletal muscle cells via a PME-1/PP2A/PKB signalling axis

    Lipina, C. & Hundal, H. S. Nov 2014 In : Cellular Signalling. 26, 11, p. 2343-2349 6 p.

    Research output: Contribution to journalArticle

  16. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

    Bago, R., Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G. & Alessi, D. R. Nov 2014 In : Biochemical Journal. 463, 3, p. 413-427 15 p.

    Research output: Contribution to journalArticle

  17. Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype

    Morrison, V. L., James, M. J., Grzes, K., Cook, P., Glass, D. G., Savinko, T., Lek, H. S., Gawden-Bone, C., Watts, C., Millington, O. R., MacDonald, A. S. & Fagerholm, S. C. 28 Oct 2014 In : Nature Communications. 5, 13 p.5359

    Research output: Contribution to journalArticle

  18. A crucial role for β2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells

    Gawden-Bone, C., West, M. A., Morrison, V. L., Edgar, A. J., McMillan, S. J., Dill, B. D., Trost, M., Prescott, A., Fagerholm, S. C. & Watts, C. 1 Oct 2014 In : Journal of Cell Science. 127, 19, p. 4213-4224 12 p.

    Research output: Contribution to journalArticle

  19. Siglec-mediated regulation of immune cell function in disease

    Macauley, M. S., Crocker, P. R. & Paulson, J. C. Oct 2014 In : Nature Reviews Immunology. 14, 10, p. 653-666 14 p.

    Research output: Contribution to journalArticle

  20. Valuation of hospital bed-days released by infection control programs: a comparison of methods

    Stewardson, A. J., Harbarth, S., Graves, N. & TIMBER Study Group Oct 2014 In : Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America. 35, 10, p. 1294-1297 4 p.

    Research output: Contribution to journalArticle

  21. Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells

    Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A. 2 Sep 2014 In : PLoS ONE. 9, 9, 7 p.e106710

    Research output: Contribution to journalArticle

  22. Peripheral prion disease pathogenesis is unaltered in the absence of sialoadhesin (Siglec-1/CD169)

    Bradford, B. M., Crocker, P. R. & Mabbott, N. A. 1 Sep 2014 In : Immunology. 143, 1, p. 120-129 10 p.

    Research output: Contribution to journalArticle

  23. Introduction to special issue: 'emerging roles of siglecs in health and disease'

    Crocker, P. R. & Kannagi, R. Sep 2014 In : Glycobiology. 24, 9, p. 784-784 1 p.

    Research output: Contribution to journalArticle

  24. Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus

    Chang, Y-C., Olson, J., Louie, A., Crocker, P. R., Varki, A. & Nizet, V. Sep 2014 In : Journal of Molecular Medicine. 92, 9, p. 951-959 9 p.

    Research output: Contribution to journalArticle

  25. Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung

    McMillan, S. J., Sharma, R. S., Richards, H. E., Hegde, V. & Crocker, P. R. 18 Jul 2014 In : Journal of Biological Chemistry. 289, 29, p. 20370-20376 7 p.

    Research output: Contribution to journalArticle

  26. Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system?

    Lipina, C., Irving, A. J. & Hundal, H. S. 1 Jul 2014 In : American Journal of Physiology, Endocrinology and Metabolism. 307, 1, p. E1-E13

    Research output: Contribution to journalArticle

  27. PDK1 controls upstream PI3K expression and PIP3 generation

    Dieterle, A. M., Böhler, P., Keppeler, H., Alers, S., Berleth, N., Drießen, S., Hieke, N., Pietkiewicz, S., Löffler, A. S., Peter, C., Gray, A., Leslie, N. R., Shinohara, H., Kurosaki, T., Engelke, M., Wienands, J., Bonin, M., Wesselborg, S. & Stork, B. 5 Jun 2014 In : Oncogene. 33, 23, p. 3043-3053 11 p.

    Research output: Contribution to journalArticle

  28. Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies

    Pearce, O. M. T., Läubli, H., Verhagen, A., Secrest, P., Zhang, J., Varki, N. M., Crocker, P. R., Bui, J. D. & Varki, A. 22 Apr 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 16, p. 5998-6003 6 p.

    Research output: Contribution to journalArticle

  29. Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

    Hawley, S. A., Ross, F. A., Gowans, G. J., Tibarewal, P., Leslie, N. R. & Hardie, D. G. 15 Apr 2014 In : Biochemical Journal. 459, 2, p. 275-287 13 p.

    Research output: Contribution to journalArticle

  30. A new protein kinase cascade

    Hardie, D. G. Apr 2014 In : Nature Reviews Molecular Cell Biology. 15, 4, p. 223 1 p.

    Research output: Contribution to journalArticle

  31. Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors

    Liu, R., Iadevaia, V., Averous, J., Taylor, P. M., Zhang, Z. & Proud, C. G. Apr 2014 In : Nucleic Acids Research. 42, 8, p. 5083-5096 14 p.

    Research output: Contribution to journalArticle

  32. A H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation

    Sabbattini, P., Sjoberg, M., Nikic, S., Frangini, A., Holmqvist, P-H., Kunowska, N., Carroll, T., Brookes, E., Arthur, S. J., Pombo, A. & Dillon, N. 15 Mar 2014 In : Molecular Biology of the Cell. 25, 6, p. 904-915 12 p.

    Research output: Contribution to journalArticle

  33. Transcriptionally correlated subcellular dynamics of MBNL1 during lens development and their implication for the molecular pathology of myotonic dystrophy type 1

    Coleman, S. M., Prescott, A. R. & Sleeman, J. E. 1 Mar 2014 In : Biochemical Journal. 458, 2, p. 267-280 14 p.

    Research output: Contribution to journalArticle

  34. AMPK: regulating energy balance at the cellular and whole body levels

    Hardie, D. G. & Ashford, M. L. J. Mar 2014 In : Physiology. 29, 2, p. 99-107 9 p.

    Research output: Contribution to journalArticle

  35. Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A

    Nardi, F., Lipina, C., Magill, D., Hage Hassan, R., Hajduch, E., Gray, A. & Hundal, H. S. Mar 2014 In : PLoS ONE. 9, 3, 10 p.e92255

    Research output: Contribution to journalArticle

  36. The catalytic subunit of the system L1 amino acid transporter (Slc7a5) facilitates nutrient signalling in mouse skeletal muscle

    Poncet, N., Mitchell, F. E., Ibrahim, A. F. M., McGuire, V. A., English, G., Arthur, J. S. C., Shi, Y-B. & Taylor, P. M. 26 Feb 2014 In : PLoS ONE. 9, 2, 14 p.e89547

    Research output: Contribution to journalArticle

  37. Time-resolved quantitative proteomics implicates the core snRNP protein SmB together with SMN in neural trafficking

    Prescott, A. R., Bales, A., James, J., Trinkle-Mulcahy, L. & Sleeman, J. E. 15 Feb 2014 In : Journal of Cell Science. 127, 4, p. 812-827 16 p.

    Research output: Contribution to journalArticle

  38. AMPK: a cellular energy sensor primarily regulated by AMP

    Gowans, G. J. & Hardie, D. G. 1 Feb 2014 In : Biochemical Society Transactions. 42, 1, p. 71-75 5 p.

    Research output: Contribution to journalArticle

  39. RAM function is dependent on Kapβ2-mediated nuclear entry

    Gonatopoulos-Pournatzis, T. & Cowling, V. H. 1 Feb 2014 In : Biochemical Journal. 457, 3, p. 473-484 12 p.

    Research output: Contribution to journalArticle

  40. Cap-binding complex (CBC)

    Gonatopoulos-Pournatzis, T. & Cowling, V. H. 15 Jan 2014 In : Biochemical Journal. 457, 2, p. 231-242 12 p.

    Research output: Contribution to journalScientific review

  41. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

    Banerjee, S., Buhrlage, S. J., Huang, H-T., Deng, X., Zhou, W., Wang, J., Traynor, R., Prescott, A. R., Alessi, D. R. & Gray, N. S. 1 Jan 2014 In : Biochemical Journal. 457, 1, p. 215-225 11 p.

    Research output: Contribution to journalArticle

  42. Role of amino acid transporters in amino acid sensing

    Taylor, P. M. Jan 2014 In : American Journal of Clinical Nutrition. 99, 1, p. 2235-2305 71 p.

    Research output: Contribution to journalArticle

  43. Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK-TssFG sub-complex

    English, G., Byron, O., Cianfanelli, F. R., Prescott, A. R. & Coulthurst, S. J. 2014 In : Biochemical Journal. 461, 2, p. 291-304 14 p.

    Research output: Contribution to journalArticle

  44. Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insight

    Mahfouz, R., Khoury, R., Blachnio-Zabielska, A., Turban, S., Loiseau, N., Lipina, C., Stretton, C., Bourron, O., Ferré, P., Foufelle, F., Hundal, H. S. & Hajduch, E. 2014 In : PLoS ONE. 9, 7, 9 p.e101865

    Research output: Contribution to journalArticle

  45. Cystatin F regulates proteinase activity in IL-2-activated natural killer cells

    Maher, K., Konjar, S., Watts, C., Turk, B. & Kopitar-Jerala, N. 2014 In : Protein and Peptide Letters. 21, 9, p. 957-965 9 p.

    Research output: Contribution to journalArticle

  46. High-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC proteomics

    Güther, M. L. S., Urbaniak, M., Tavendale, A., Prescott, A. & Ferguson, M. A. J. 2014 In : Journal of Proteome Research. 13, 6, p. 2796-2806 11 p.

    Research output: Contribution to journalArticle

  47. Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase

    Banerjee, S., Zagorska, A., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R. 2014 In : Biochemical Journal. 461, 2, p. 233-245 13 p.

    Research output: Contribution to journalArticle

  48. Leucoerythroblastic anaemia, abnormal bone scan and prostate cancer with a primary haematological diagnosis

    Preston, G., Meiklejohn, D. & Thomas, N. 2014 In : British Journal of Haematology. 1 p.

    Research output: Contribution to journalArticle

  49. Mechanism of Action of Compound-13: an α1-Selective Small Molecule Activator of AMPK

    Hunter, R. W., Foretz, M., Bultot, L., Fullerton, M. D., Deak, M., Ross, F. A., Hawley, S. A., Shpiro, N., Viollet, B., Barron, D., Kemp, B. E., Steinberg, G. R., Hardie, D. G. & Sakamoto, K. 2014 In : Chemistry & Biology. 21, 7, p. 866-879 14 p.

    Research output: Contribution to journalArticle

  50. Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model

    McMillan, S. J., Richards, H. E. & Crocker, P. R. 2014 In : Immunology Letters. 160, 1, p. 11-16 6 p.

    Research output: Contribution to journalArticle

  51. Structural and functional basis for p38-MK2 activated Rsk signalling in TLR stimulated dendritic cells

    Zaru, R., Edgar, A. J., Hanauer, A. & Watts, C. 2014 In : Molecular and Cellular Biology. 30 p.

    Research output: Contribution to journalArticle

  52. Transcriptional regulation of IL-10 and its cell-specific role in vivo

    MacKenzie, K. F., Pattison, M. J. & Arthur, J. S. C. 2014 In : Critical Reviews in Immunology. 34, 4, p. 315-345 31 p.

    Research output: Contribution to journalArticle

  53. Characterization of Native Protein Complexes and Protein Isoform Variation Using Size-fractionation-based Quantitative Proteomics

    Kirkwood, K. J., Ahmad, Y., Larance, M. & Lamond, A. I. 1 Dec 2013 In : Molecular & Cellular Proteomics. 12, 12, p. 3851-3873 23 p.

    Research output: Contribution to journalArticle

  54. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis

    von Wilamowitz-Moellendorff, A., Hunter, R. W., García-Rocha, M., Kang, L., López-Soldado, I., Lantier, L., Patel, K., Peggie, M. W., Martínez-Pons, C., Voss, M., Calbó, J., Cohen, P. T. W., Wasserman, D. H., Guinovart, J. J. & Sakamoto, K. Dec 2013 In : Diabetes. 62, 12, p. 4070-4082 13 p.

    Research output: Contribution to journalArticle

  55. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

    Brown, S. J. & 33 others Saunders, S. P., Goh, C. S. M., Palmer, C. N. A., Porter, R. M., Cole, C., Campbell, L. E., Gierlinski, M., Barton, G. J., Schneider, G., Balmain, A., Prescott, A. R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y-A., Tavendale, R., Mukhopadhyay, S., Turner, S. W., Madhok, V. B., Sullivan, F. M., Relton, C., Burn, J., Meggitt, S., Smith, C. H., Allen, M. A., Barker, J. N. W. N., Reynolds, N. J., Cordell, H. J., Irvine, A. D., McLean, W. H. I., Sandilands, A. & Fallon, P. G. Nov 2013 In : Journal of Allergy and Clinical Immunology. 132, 5, p. 1121-1129 9 p.

    Research output: Contribution to journalArticle

  56. A synthetic system for expression of components of a bacterial microcompartment

    Sargent, F., Davidson, F. A., Kelly, C. L., Binny, R., Christodoulides, N., Gibson, D., Johansson, E., Kozyrska, K., Licandro Lado, L., MacCallum, J., Montague, R., Ortmann, B., Owen, R., Coulthurst, S. J., Dupuy, L., Prescott, A. R. & Palmer, T. Nov 2013 In : Microbiology-SGM. 159, 11, p. 2427-2436 10 p.

    Research output: Contribution to journalArticle

  57. The interferon response to intracellular DNA: Why so many receptors?

    Unterholzner, L. Nov 2013 In : Immunobiology. 218, 11, p. 1312-1321 10 p.

    Research output: Contribution to journalArticle

  58. Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases

    Castor, D., Nair, N., Déclais, A-C., Lachaud, C., Toth, R., Macartney, T. J., Lilley, D. M. J., Arthur, J. S. C. & Rouse, J. 24 Oct 2013 In : Molecular Cell. 52, 2, p. 221-233 13 p.

    Research output: Contribution to journalArticle

  59. AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

    Gowans, G. J., Hawley, S. A., Ross, F. A. & Hardie, D. G. 1 Oct 2013 In : Cell Metabolism. 18, 4, p. 556-566 11 p.

    Research output: Contribution to journalArticle

  60. Mitochondrial Substrate Availability and its Role in Lipid-Induced Insulin Resistance and Proinflammatory Signalling in Skeletal Muscle

    Lipina, C., Macrae, K., Suhm, T., Weigert, C., Blachnio-Zabielska, A., Baranowksi, M., Gorski, J., Burgess, K. & Hundal, H. S. Oct 2013 In : Diabetes. 62, 10, p. 3426-3436 11 p.

    Research output: Contribution to journalArticle

  61. Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

    Emmerich, C. H., Ordureau, A., Strickson, S., Arthur, J. S. C., Pedrioli, P. G. A., Komander, D. & Cohen, P. 17 Sep 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 38, p. 15247-15252 6 p.

    Research output: Contribution to journalArticle

  62. Localization-dependent and -independent roles of SLX4 in regulating telomeres

    Wilson, J. S. J., Tejera, A. M., Castor, D., Toth, R., Blasco, M. A. & Rouse, J. 12 Sep 2013 In : Cell Reports. 4, 5, p. 853-860 8 p.

    Research output: Contribution to journalArticle

  63. Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells

    Ulvestad, M., Nordell, P., Asplund, A., Rehnström, M., Jacobsson, S., Holmgren, G., Davidson, L., Brolén, G., Edsbagge, J., Björquist, P., Küppers-Munther, B. & Andersson, T. B. 1 Sep 2013 In : Biochemical Pharmacology. 86, 5, p. 691-702 12 p.

    Research output: Contribution to journalArticle

  64. Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with γ-tubulin

    Voss, M., Campbell, K., Saranzewa, N., Campbell, D. G., Hastie, C. J., Peggie, M. W., Martin-Granados, C., Prescott, A. R. & Cohen, P. T. W. 1 Sep 2013 In : Cell Cycle. 12, 17, p. 2876-2887 12 p.

    Research output: Contribution to journalArticle

  65. Defining the role of DAG, mitochondrial function, and lipid deposition in palmitate-induced proinflammatory signaling and its counter-modulation by palmitoleate

    Macrae, K., Stretton, C., Lipina, C., Blachnio-Zabielska, A., Baranowski, M., Gorski, J., Marley, A. & Hundal, H. S. Sep 2013 In : Journal of Lipid Research. 54, 9, p. 2366-2378 13 p.

    Research output: Contribution to journalArticle

  66. Mitogen-activated protein kinases in innate immunity

    Arthur, J. S. C. & Ley, S. C. Sep 2013 In : Nature Reviews Immunology. 13, 9, p. 679-692 14 p.

    Research output: Contribution to journalArticle

  67. DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA

    Ordureau, A., Enesa, K., Nanda, S., Le Francois, B., Peggie, M., Prescott, A., Albert, P. R. & Cohen, P. 23 Aug 2013 In : Journal of Biological Chemistry. 288, 34, p. 24569-24580 12 p.

    Research output: Contribution to journalArticle

  68. The β2 integrin–kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo

    Morrison, V. L., MacPherson, M., Savinko, T., San Lek, H., Prescott, A. & Fagerholm, S. C. 22 Aug 2013 In : Blood. 122, 8, p. 1428-1436 9 p.

    Research output: Contribution to journalArticle

  69. BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm

    Hobley, L., Ostrowski, A., Rao, F. V., Bromley, K. M., Porter, M., Prescott, A. R., Macphee, C. E., van Aalten, D. M. F. & Stanley-Wall, N. R. 13 Aug 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13600-13605 6 p.

    Research output: Contribution to journalArticle

  70. AMPK: a target for drugs and natural products with effects on both diabetes and cancer

    Hardie, D. G. Jul 2013 In : Diabetes. 62, 7, p. 2164-2172 9 p.

    Research output: Contribution to journalArticle

  71. X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor

    Elkins, J. M., Wang, J., Deng, X., Pattison, M. J., Arthur, J. S. C., Erazo, T., Gomez, N., Lizcano, J. M., Gray, N. S. & Knapp, S. 13 Jun 2013 In : Journal of Medicinal Chemistry. 56, 11, p. 4413-4421 9 p.

    Research output: Contribution to journalArticle

  72. The spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow

    Lek, H. S., Morrison, V. L., Conneely, M., Campbell, P. A., McGloin, D., Kliche, S., Watts, C., Prescott, A. & Fagerholm, S. C. 24 May 2013 In : Journal of Biological Chemistry. 288, 21, p. 14698-14708 11 p.

    Research output: Contribution to journalArticle

  73. IFNβ autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages

    Pattison, M. J., MacKenzie, K. F., Elcombe, S. E. & Arthur, J. S. C. 21 May 2013 In : FEBS Letters. 587, 10, p. 1496-1503 8 p.

    Research output: Contribution to journalArticle

  74. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

    Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y-B., Taylor, P. M. & Cantrell, D. A. May 2013 In : Nature Immunology. 14, 5, p. 500-508 9 p.

    Research output: Contribution to journalArticle

  75. miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity

    Remenyi, J., van den Bosch, M. W. M., Palygin, O., Mistry, R. B., McKenzie, C., Macdonald, A., Hutvagner, G., Arthur, J. S. C., Frenguelli, B. G. & Pankratov, Y. 26 Apr 2013 In : PLoS ONE. 8, 4, 14 p.e62509

    Research output: Contribution to journalArticle

  76. LKB1 and AMPK and the cancer-metabolism link - ten years after

    Hardie, D. G. & Alessi, D. R. 15 Apr 2013 In : BMC Biology. 11, 11 p.36

    Research output: Contribution to journalArticle

  77. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

    Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3 Apr 2013 In : EMBO Journal. 32, 7, p. 1008-22 15 p.

    Research output: Contribution to journalArticle

  78. AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

    Dandapani, M. & Hardie, D. G. Apr 2013 In : Biochemical Society Transactions. 41, 2, p. 687-693 7 p.

    Research output: Contribution to journalArticle

  79. AMPKα1: a glucose sensor that controls CD8 T-cell memory

    Rolf, J., Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A. Apr 2013 In : European Journal of Immunology. 43, 4, p. 889-896 8 p.

    Research output: Contribution to journalArticle

  80. MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop

    MacKenzie, K. F., Van den Bosch, M. W. M., Naqvi, S., Elcombe, S. E., McGuire, V. A., Reith, A. D., Blackshear, P. J., Dean, J. L. E. & Arthur, J. S. C. Apr 2013 In : Molecular and Cellular Biology. 33, 7, p. 1456-1467 12 p.

    Research output: Contribution to journalArticle

  81. The system L1 amino acid transporter (SLC7A5) facilitates nutrient signalling in mouse skeletal muscle in vivo

    Poncet, N. & Taylor, P. M. Apr 2013 In : FASEB Journal. 27, Suppl., 1 p.350.4

    Research output: Contribution to journalMeeting abstract

  82. Dectin-1 Regulates IL-10 Production via a MSK1/2 and CREB Dependent Pathway and Promotes the Induction of Regulatory Macrophage Markers

    Elcombe, S. E., Naqvi, S., Van den Bosch, M. W. M., MacKenzie, K. F., Cianfanelli, F., Brown, G. D. & Arthur, J. S. C. 22 Mar 2013 In : PLoS ONE. 8, 3, 15 p.e60086

    Research output: Contribution to journalArticle

  83. LKB1 Mediates the Development of Conventional and Innate T Cells via AMP-Dependent Kinase Autonomous Pathways

    Zarrouk, M., Rolf, J. & Cantrell, D. A. 22 Mar 2013 In : PLoS ONE. 8, 3, 9 p.e60217

    Research output: Contribution to journalArticle

  84. Sialoadhesin ligand expression identifies a subpopulation of Foxp3- T cells with a distinct activation and glycosylation profile

    Kidder, D., Richards, H. E., Ziltener, H. J., Garden, O. A. & Crocker, P. R. 15 Mar 2013 In : Journal of Immunology. 190, 6, p. 2593-2602 10 p.

    Research output: Contribution to journalArticle

  85. Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling

    McMillan, S. J., Sharma, R. S., McKenzie, E. J., Richards, H. E., Zhang, J., Prescott, A. & Crocker, P. R. 14 Mar 2013 In : Blood. 121, 11, p. 2084-2094 11 p.

    Research output: Contribution to journalArticle

  86. Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors

    Horan, K. A., Hansen, K., Jakobsen, M. R., Holm, C. K., Søby, S., Unterholzner, L., Thompson, M., West, J. A., Iversen, M. B., Rasmussen, S. B., Ellermann-Eriksen, S., Kurt-Jones, E., Landolfo, S., Damania, B., Melchjorsen, J., Bowie, A. G., Fitzgerald, K. A. & Paludan, S. R. 1 Mar 2013 In : Journal of Immunology. 190, 5, p. 2311-2319 9 p.

    Research output: Contribution to journalArticle

  87. Global subcellular characterization of protein degradation using quantitative proteomics

    Larance, M., Ahmad, Y., Kirkwood, K. J., Ly, T. & Lamond, A. I. Mar 2013 In : Molecular & Cellular Proteomics. 12, 3, p. 638-650 13 p.

    Research output: Contribution to journalArticle

  88. Hormonal regulation of the Salt-inducible Kinase (SIK), a key mediator that controls hepatic gluconeogenesis

    Patel, K., Goransson, O., Sutherland, C. & Sakamoto, K. Mar 2013 In : Diabetic Medicine. 30, Suppl. 1, p. E2-E2 1 p.P577

    Research output: Contribution to journalMeeting abstract

  89. Hormonal regulation of the Salt-inducible Kinase (SIK), a key mediator that controls hepatic gluconeogenesis

    Patel, K., Goransson, O., Sutherland, C. & Sakamoto, K. Mar 2013

    Research output: Contribution to conferencePoster

  90. Insulin sensitising effects of monounsaturated and polyunsaturated fatty acids in skeletal muscle cells

    Nardi, F., Lipina, C., Magill, D. & Hundal, H. S. Mar 2013 In : Diabetic Medicine. 30, Suppl. 1, p. 49-49 1 p.P70

    Research output: Contribution to journalMeeting abstract

  91. Obesity-Induced Insulin Resistance in Human Skeletal Muscle Is Characterised by Defective Activation of p42/p44 MAP Kinase

    Ruiz-Alcaraz, A. J., Lipina, C., Petrie, J. R., Murphy, M. J., Morris, A. D., Sutherland, C. & Cuthbertson, D. J. 28 Feb 2013 In : PLoS ONE. 8, 2, e56928

    Research output: Contribution to journalArticle

  92. Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence

    Mansur, D. S., Maluquer de Motes, C., Unterholzner, L., Sumner, R. P., Ferguson, B. J., Ren, H., Strnadova, P., Bowie, A. G. & Smith, G. L. 28 Feb 2013 In : PLoS Pathogens. 9, 2, e1003183

    Research output: Contribution to journalArticle

  93. Metabolism of inflammation limited by AMPK and pseudo-starvation

    O'Neill, L. A. J. & Hardie, D. G. 17 Jan 2013 In : Nature. 493, 7432, p. 346-355 10 p.

    Research output: Contribution to journalArticle

  94. PGE2 induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway

    Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15 Jan 2013 In : Journal of Immunology. 190, 2, p. 565-577 13 p.

    Research output: Contribution to journalArticle

  95. Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo

    Belch, J. J. F., Akbar, N., Alapati, V., Petrie, J., Arthur, S. & Khan, F. Jan 2013 In : Microvascular Research. 85, p. 86-92 7 p.

    Research output: Contribution to journalArticle

  96. The role of amino acid transporters in nutrition

    Poncet, N. & Taylor, P. M. Jan 2013 In : Current Opinion in Clinical Nutrition and Metabolic Care. 16, 1, p. 57-65 9 p.

    Research output: Contribution to journalArticle

  97. AMPK: mediating the metabolic effects of salicylate-based drugs?

    Steinberg, G. R., Dandapani, M. & Hardie, D. G. 2013 In : Trends in Endocrinology and Metabolism. 24, 10, p. 481-487 7 p.

    Research output: Contribution to journalArticle

  98. Chronic exposure of astrocytes to interferon-alpha reveals molecular changes related to Aicardi-Goutieres syndrome

    Cuadrado, E., Jansen, M. H., Anink, J., De Filippis, L., Vescovi, A. L., Watts, C., Aronica, E., Hol, E. M. & Kuijpers, T. W. 2013 In : Brain. 136, 1, p. 245-258 14 p.

    Research output: Contribution to journalArticle

  99. Cross talk between the Akt and p38α pathways in macrophages downstream of toll-like receptor signaling

    McGuire, V. A., Gray, A., Monk, C. E., Santos, S. G., Lee, K., Aubareda, A., Crowe, J., Ronkina, N., Schwermann, J., Batty, I. H., Leslie, N. R., Dean, J. L. E., O'Keefe, S. J., Boothby, M., Gaestel, M. & Arthur, J. S. C. 2013 In : Molecular and Cellular Biology. 33, 21, p. 4152-4165 14 p.

    Research output: Contribution to journalArticle

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