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  1. IFNβ autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages

    Pattison, M. J., MacKenzie, K. F., Elcombe, S. E. & Arthur, J. S. C. 21-May-2013 In : FEBS Letters. 587, 10, p. 1496-1503, 8 p.

    Research output: Contribution to journal › Article

  2. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

    Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y-B., Taylor, P. M. & Cantrell, D. A. May-2013 In : Nature Immunology. 14, 5, p. 500-508, 9 p.

    Research output: Contribution to journal › Article

  3. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

    Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3-Apr-2013 In : EMBO Journal. 32, 7, p. 1008-22, 15 p.

    Research output: Contribution to journal › Article

  4. AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

    Dandapani, M. & Hardie, D. G. Apr-2013 In : Biochemical Society Transactions. 41, 2, p. 687-693, 7 p.

    Research output: Contribution to journal › Article

  5. Dectin-1 Regulates IL-10 Production via a MSK1/2 and CREB Dependent Pathway and Promotes the Induction of Regulatory Macrophage Markers

    Elcombe, S. E., Naqvi, S., Van den Bosch, M. W. M., MacKenzie, K. F., Cianfanelli, F., Brown, G. D. & Arthur, J. S. C. 22-Mar-2013 In : PLoS ONE. 8, 3, 15 p., e60086

    Research output: Contribution to journal › Article

  6. LKB1 Mediates the Development of Conventional and Innate T Cells via AMP-Dependent Kinase Autonomous Pathways

    Zarrouk, M., Rolf, J. & Cantrell, D. A. 22-Mar-2013 In : PLoS ONE. 8, 3, 9 p., e60217

    Research output: Contribution to journal › Article

  7. Sialoadhesin ligand expression identifies a subpopulation of Foxp3- T cells with a distinct activation and glycosylation profile

    Kidder, D., Richards, H. E., Ziltener, H. J., Garden, O. A. & Crocker, P. R. 15-Mar-2013 In : Journal of Immunology. 190, 6, p. 2593-2602, 10 p.

    Research output: Contribution to journal › Article

  8. Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b beta2-integrin-dependent signalling

    McMillan, S. J., Sharma, R. S., McKenzie, E. J., Richards, H. E., Zhang, J., Prescott, A. & Crocker, P. R. 14-Mar-2013 In : Blood. 121, 11, p. 2084-2094, 11 p.

    Research output: Contribution to journal › Article

  9. Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors

    Horan, K. A., Hansen, K., Jakobsen, M. R., Holm, C. K., Søby, S., Unterholzner, L., Thompson, M., West, J. A., Iversen, M. B., Rasmussen, S. B., Ellermann-Eriksen, S., Kurt-Jones, E., Landolfo, S., Damania, B., Melchjorsen, J., Bowie, A. G., Fitzgerald, K. A. & Paludan, S. R. 1-Mar-2013 In : Journal of Immunology. 190, 5, p. 2311-2319, 9 p.

    Research output: Contribution to journal › Article

  10. Hormonal regulation of the Salt-inducible Kinase (SIK), a key mediator that controls hepatic gluconeogenesis

    Patel, K., Goransson, O., Sutherland, C. & Sakamoto, K. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. E2-E2, 1 p., P577

    Research output: Contribution to journal › Meeting abstract

  11. Hormonal regulation of the Salt-inducible Kinase (SIK), a key mediator that controls hepatic gluconeogenesis

    Patel, K., Goransson, O., Sutherland, C. & Sakamoto, K. Mar-2013

    Research output: Contribution to conference › Poster

  12. Insulin sensitising effects of monounsaturated and polyunsaturated fatty acids in skeletal muscle cells

    Nardi, F., Lipina, C., Magill, D. & Hundal, H. S. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. 49-49, 1 p., P70

    Research output: Contribution to journal › Meeting abstract

  13. Obesity-Induced Insulin Resistance in Human Skeletal Muscle Is Characterised by Defective Activation of p42/p44 MAP Kinase

    Ruiz-Alcaraz, A. J., Lipina, C., Petrie, J. R., Murphy, M. J., Morris, A. D., Sutherland, C. & Cuthbertson, D. J. 28-Feb-2013 In : PLoS ONE. 8, 2, e56928

    Research output: Contribution to journal › Article

  14. Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence

    Mansur, D. S., Maluquer de Motes, C., Unterholzner, L., Sumner, R. P., Ferguson, B. J., Ren, H., Strnadova, P., Bowie, A. G. & Smith, G. L. 28-Feb-2013 In : PLoS Pathogens. 9, 2, e1003183

    Research output: Contribution to journal › Article

  15. Metabolism of inflammation limited by AMPK and pseudo-starvation

    O'Neill, L. A. J. & Hardie, D. G. 17-Jan-2013 In : Nature. 493, 7432, p. 346-355, 10 p.

    Research output: Contribution to journal › Article

  16. PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway

    Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15-Jan-2013 In : Journal of Immunology. 190, 2, p. 565-77, 13 p.

    Research output: Contribution to journal › Article

  17. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

    MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S. & Tauro, S. 1-Jan-2013 In : Scientific Reports. 3, 1275

    Research output: Contribution to journal › Article

  18. Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo

    Belch, J. J. F., Akbar, N., Alapati, V., Petrie, J., Arthur, S. & Khan, F. Jan-2013 In : Microvascular Research. 85, p. 86-92, 7 p.

    Research output: Contribution to journal › Article

  19. The role of amino acid transporters in nutrition

    Poncet, N. & Taylor, P. M. Jan-2013 In : Current Opinion in Clinical Nutrition and Metabolic Care. 16, 1, p. 57-65, 9 p.

    Research output: Contribution to journal › Article

  20. Chronic exposure of astrocytes to interferon-alpha reveals molecular changes related to Aicardi-Goutieres syndrome

    Cuadrado, E., Jansen, M. H., Anink, J., De Filippis, L., Vescovi, A. L., Watts, C., Aronica, E., Hol, E. M. & Kuijpers, T. W. 2013 In : Brain. 136, 1, p. 245-258, 14 p.

    Research output: Contribution to journal › Article

  21. Insulin sensitising effects of monounsaturated and polyunsaturated fatty acids in skeletal muscle cells

    Nardi, F., Lipina, C., Magill, D. & Hundal, H. S. 2013

    Research output: Contribution to conference › Poster

  22. MSK1 and 2 inhibit LPS induced prostaglandin production via an IL-10 feedback loop

    Mackenzie, K. F., Van Den Bosch, M. W. M., Naqvi, S., Elcombe, S. E., McGuire, V. A., Reith, A. D., Blackshear, P. J., Dean, J. L. & Arthur, J. S. C. 2013 In : Molecular and Cellular Biology.

    Research output: Contribution to journal › Article

  23. Phospholipase C-eta 2 is required for retinoic acid-stimulated neurite growth

    Popovics, P., Gray, A., Arastoo, M., Finelli, D. K., Tan, A. J. L. & Stewart, A. J. 2013 In : Journal of Neurochemistry. 124, 5, p. 632-644, 13 p.

    Research output: Contribution to journal › Article

  24. The LKB1-AMPK Pathway-Friend or Foe in Cancer?

    Hardie, D. G. 2013 In : Cancer Cell. 23, 2, p. 131-132, 2 p.

    Research output: Contribution to journal › Editorial

  25. The specificity of the interaction between αB-crystallin and desmin filaments and its impact on filament aggregation and cell viability

    Elliott, J. L., Der Perng, M., Prescott, A. R., Jansen, K. A., Koenderink, G. H. & Quinlan, R. A. 2013 In : Philosophical Transactions of the Royal Society B - Biological Sciences. 368, 1617, p. 1-15, 15 p.

    Research output: Contribution to journal › Article

  26. The spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow

    Lek, H. S., Morrison, V. L., Conneely, M., Campbell, P. A., McGloin, D., Kliche, S., Watts, C., Prescott, A. & Fagerholm, S. C. 2013 In : Journal of Biological Chemistry.

    Research output: Contribution to journal › Article

  27. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells

    Finlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L., Rolf, J., Panteleyev, A. A., Okkenhaug, K. & Cantrell, D. A. 17-Dec-2012 In : Journal of Experimental Medicine. 209, 13, p. 2441-2453, 13 p.

    Research output: Contribution to journal › Article

  28. Selective kinase inhibitors as tools for neuroscience research

    Martin, K. J. & Arthur, J. S. C. Dec-2012 In : Neuropharmacology. 63, 7, p. 1227-1237, 11 p.

    Research output: Contribution to journal › Article

  29. Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

    McIver, E. G., Bryans, J., Birchall, K., Chugh, J., Drake, T., Lewis, S. J., Osborne, J., Smiljanic-Hurley, E., Tsang, W., Kamal, A., Levy, A., Newman, M., Taylor, D., Arthur, J. S. C., Clark, K. & Cohen, P. Dec-2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 23, p. 7169-7173, 5 p.

    Research output: Contribution to journal › Article

  30. ZNRF2 is released from membranes by growth factors and with ZNRF1 regulates the Na+/K+ATPase

    Hoxhaj, G., Najafov, A., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 1-Oct-2012 In : Journal of Cell Science. 125, 19, p. 4662-4675

    Research output: Contribution to journal › Article

  31. AKT independent glioma suppression by PTEN

    Zilidis, G., Tibarewal, P., Spinelli, L. & Leslie, N. R. Sep-2012 In : Journal of Neuro-Oncology. 14, p. 8-8, 1 p.

    Research output: Contribution to journal › Meeting abstract

  32. System L amino acid transporter 1 (slc7a5) expression is crucial for T cell blastogenesis

    Sinclair, L. V., Taylor, P. M. & Cantrell, D. A. Sep-2012 In : Immunology. 137, s1, p. 347-347, 1 p.

    Research output: Contribution to journal › Meeting abstract

  33. New vistas for treatment of obesity and diabetes?: Endocannabinoid signalling and metabolism in the modulation of energy balance

    Lipina, C., Rastedt, W., Irving, A. J. & Hundal, H. S. 1-Aug-2012 In : BioEssays. 34, 8, p. 681-691, 11 p.

    Research output: Contribution to journal › Article

  34. P38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

    Risco, A., Del Dresno, C., Mambol, A., Alsina-Beauchamp, D., MacKenzie, K. F., Yang, H-T., Barber, D. F., Morcelle, C., Arthur, J. S. C., Ley, S. C., Ardavin, C. F. & Cuenda, A. 10-Jul-2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 28, p. 11200-11205, 6 p.

    Research output: Contribution to journal › Article

  35. IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold

    Dixon, M. J., Gray, A., Schenning, M., Agacan, M., Tempel, W., Tong, Y., Nedyalkova, L., Park, H-W., Leslie, N. R., van Aalten, D. M. F., Downes, C. P. & Batty, I. H. 29-Jun-2012 In : Journal of Biological Chemistry. 287, 27, p. 22483-22496, 14 p.

    Research output: Contribution to journal › Article

  36. The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor signaling

    Dzamko, N., Inesta-Vaquera, F., Zhang, J., Arthur, S., Cohen, P., Clark, K., Alessi, D. R., Xie, C., Cai, H., Tan, L., Choi, H., Gray, N. & Pedrioli, P. 18-Jun-2012 In : PLoS ONE. 7, 6, e39132

    Research output: Contribution to journal › Article

  37. Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells

    Turban, S., Stretton, C., Drouin, O., Green, C. J., Watson, M. L., Gray, A., Ross, F., Lantier, L., Viollet, B., Hardie, D. G., Hundal, H. S. & Marette, A. 8-Jun-2012 In : Journal of Biological Chemistry. 287, 24, p. 20088-20099, 12 p.

    Research output: Contribution to journal › Article

  38. E2F1-dependent methyl cap formation requires RNA pol II phosphorylation

    Aregger, M. & Cowling, V. H. 1-Jun-2012 In : Cell Cycle. 11, 11, p. 2146-2148, 3 p.

    Research output: Contribution to journal › Article

  39. Cellular Responses to the Metal-Binding Properties of Metformin

    Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H-H., Xue, L., Jiang, H., Sakamoto, K., Prescott, A. R. & Rena, G. Jun-2012 In : Diabetes. 61, 6, p. 1423-1433, 11 p.

    Research output: Contribution to journal › Article

  40. Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells

    Magister, Š., Obermajer, N., Mirković, B., Švajger, U., Renko, M., Softić, A., Romih, R., Colbert, J. D., Watts, C. & Kos, J. 1-May-2012 In : European Journal of Cell Biology. 91, 5, p. 391-401, 11 p.

    Research output: Contribution to journal › Article

  41. A pan-endosomal protease inhibitor attenuates endosomal function and improves antigen presentation

    van Kasteren, S., Colbert, J., Berlin, I., Matthews, S., Groettrup, M., Mueller, M., Keane, D. & Watts, C. May-2012 In : Molecular Immunology. 51, 1, p. 34-34, 1 p.

    Research output: Contribution to journal › Special issue

  42. MC1R determines melanocyte viability upon UV irradiation by protecting PTEN activity

    Cao, J., Liu, F., Shen, J., Lenna, S., Jimenez-Cervantes, S., Leslie, N., Xu, G. X., Wang, Y. & Cui, R. May-2012 In : Journal of Investigative Dermatology. 132, p. S126-S126, 1 p.

    Research output: Contribution to journal › Article

  43. Organismal Carbohydrate and Lipid Homeostasis

    Hardie, D. G. May-2012 In : Cold Spring Harbor Perspectives in Biology. 4, 5, p. -, 16 p., a006031

    Research output: Contribution to journal › Article

  44. Protein kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues

    Matthews, S. A., San Lek, H., Morrison, V. L., Mackenzie, M. G., Zarrouk, M., Cantrell, D. & Fagerholm, S. C. May-2012 In : European Journal of Immunology. 42, 5, p. 1316-1326, 11 p.

    Research output: Contribution to journal › Article

  45. Structures of the HIN domain: DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor

    Jin, T., Perry, A., Jiang, J., Smith, P., Curry, J. A., Unterholzner, L., Jiang, Z., Horvath, G., Rathinam, V. A., Johnstone, R. W., Hornung, V., Latz, E., Bowie, A. G., Fitzgerald, K. A. & Xiao, T. S. 20-Apr-2012 In : Immunity. 36, 4, p. 561-571, 11 p.

    Research output: Contribution to journal › Article

  46. AMPK: a nutrient and energy sensor that maintains energy homeostasis

    Hardie, D. G., Ross, F. A. & Hawley, S. A. 1-Apr-2012 In : Nature Reviews Molecular Cell Biology. 13, 4, p. 251-262, 12 p.

    Research output: Contribution to journal › Article

  47. The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a

    Cameron, A. R., Wallace, K., Logie, L., Prescott, A. R., Unterman, T. G., Harthill, J. & Rena, G. 1-Apr-2012 In : Biochemical Journal. 443, p. 57-64, 8 p.

    Research output: Contribution to journal › Article

  48. The role of ATM in response to metformin treatment and activation of AMPK reply

    Zhou, K., Bellenguez, C., Sutherland, C., Hardie, G., Palmer, C., Donnelly, P. & Pearson, E. Apr-2012 In : Nature Genetics. 44, 4, p. 361-362, 2 p.

    Research output: Contribution to journal › Letter

  49. Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

    Navarro, M. N., Sinclair, L. V., Feijoo-Carnero, C., Clarke, R., Matthews, S. A. & Cantrell, D. A. 15-Mar-2012 In : Biochemical Journal. 442, 3, p. 649-659, 11 p.

    Research output: Contribution to journal › Article

  50. Both p110 alpha and p110 beta isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

    Berenjeno, I. M., Guillermet-Guibert, J., Pearce, W., Gray, A., Fleming, S. & Vanhaesebroeck, B. 15-Feb-2012 In : Biochemical Journal. 442, p. 151-159, 9 p.

    Research output: Contribution to journal › Article

  51. Evolution of the vertebrate beaded filament protein, Bfsp2: comparing the in vitro assembly properties of a "tailed" zebrafish Bfsp2 to its "tailless" human orthologue

    Qu, B., Landsbury, A., Schoenthaler, H. B., Dahm, R., Liu, Y., Clark, J. I., Prescott, A. R. & Quinlan, R. A. Jan-2012 In : Experimental Eye Research. 94, 1, p. 192-202, 11 p.

    Research output: Contribution to journal › Article

  52. The endosome-lysosome pathway and information generation in the immune system

    Watts, C. Jan-2012 In : Biochimica et Biophysica Acta. Proteins and Proteomics. 1824, 1, p. 14-21, 8 p.

    Research output: Contribution to journal › Scientific review

  53. A role for PP1/NIPP1 in steering migration of human cancer cells

    Martin-Granados, C., Prescott, A. R., Van Dessel, N., Van Eynde, A., Arocena, M., Klaska, I. P., Görnemann, J., Beullens, M., Bollen, M., Forrester, J. V. & McCaig, C. D. 2012 In : PLoS ONE. 7, 7, e40769

    Research output: Contribution to journal › Article

  54. AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway

    Petti, C., Vegetti, C., Molla, A., Bersani, I., Cleris, L., Mustard, K. J., Formelli, F., Hardie, G. D., Sensi, M. & Anichini, A. 2012 In : Melanoma Research. 22, 5, p. 341-350, 10 p.

    Research output: Contribution to journal › Article

  55. AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells

    Lee, C-W., Wong, L. L-Y., Tse, E. Y-T., Liu, H-F., Leong, V. Y-L., Lee, J. M-F., Hardie, D. G., Ng, I. O-L. & Ching, Y-P. 2012 In : Cancer Research. 72, 17, p. 4394-4404, 11 p.

    Research output: Contribution to journal › Article

  56. Application of a novel highly sensitive activity-based probe for detection of cathepsin G

    Zou, F., Schmon, M., Sienczyk, M., Grzywa, R., Palesch, D., Boehm, B. O., Sun, Z. L., Watts, C., Schirmbeck, R. & Burster, T. 2012 In : Analytical Biochemistry. 421, 2, p. 667-72, 6 p.

    Research output: Contribution to journal › Article

  57. CD33-related siglecs as potential modulators of inflammatory responses

    Crocker, P. R., McMillan, S. J. & Richards, H. E. 2012 In : Annals of the New York Academy of Sciences. 1253, p. 102-111, 10 p.

    Research output: Contribution to journal › Article

  58. Disordered insulin secretion in the development of insulin resistance and Type 2 diabetes

    Schofield, C. J. & Sutherland, C. 2012 In : Diabetic Medicine. 29, 8, p. 972-979, 8 p.

    Research output: Contribution to journal › Book/Film/Article review

  59. Expression and function of thyroid hormone transporters in the microvillous plasma membrane of human term placental syncytiotrophoblast

    Loubière, L. S., Vasilopoulou, E., Glazier, J. D., Taylor, P. M., Franklyn, J. A., Kilby, M. D. & Chan, S. Y. 2012 In : Endocrinology. 153, 12, p. 6126-6135, 10 p.

    Research output: Contribution to journal › Article

  60. Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback

    Pattison, M. J., MacKenzie, K. F. & Arthur, J. S. C. 2012 In : Journal of Immunology. 189, 6, p. 2784-2792, 9 p.

    Research output: Contribution to journal › Article

  61. Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus

    Choi, Y-S., Karelina, K., Alzate-Correa, D., Hoyt, K. R., Impey, S., Arthur, J. S. & Obrietan, K. 2012 In : Journal of Neurochemistry. 123, 5, p. 676-688, 13 p.

    Research output: Contribution to journal › Article

  62. MSK1 regulates homeostatic and experience-dependent synaptic plasticity

    Corrêa, S. A. L., Hunter, C. J., Palygin, O., Wauters, S. C., Martin, K. J., McKenzie, C., McKelvey, K., Morris, R. G. M., Pankratov, Y., Arthur, J. S. C. & Frenguelli, B. 2012 In : Journal of Neuroscience. 32, 38, p. 13039-13051, 13 p.

    Research output: Contribution to journal › Article

  63. Novel methods for the quantification of changes in actin organization in chondrocytes using fluorescent imaging and linear profiling

    Qusous, A., Parker, E., Geewan, C., Kapasi, A., Getting, S. J., Hucklebridge, F., Keshavarz, T. & Kerrigan, M. J. P. 2012 In : Microscopy Research and Technique. 75, 7, p. 991-999, 9 p.

    Research output: Contribution to journal › Article

  64. Pellino1 Is Required for Interferon Production by Viral Double-stranded RNA

    Enesa, K., Ordureau, A., Smith, H., Barford, D., Cheung, P. C. F., Patterson-Kane, J., Arthur, J. S. C. & Cohen, P. 2012 In : Journal of Biological Chemistry. 287, 41, p. 34825-34835, 11 p.

    Research output: Contribution to journal › Article

  65. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

    Clark, K., Mackenzie, K. F., Petkevicius, K., Kristariyanto, Y., Zhang, J., Choi, H. G., Peggie, M., Plater, L., Pedrioli, P. G. A., McIver, E., Gray, N. S., Arthur, J. S. C. & Cohen, P. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 42, p. 16986-91, 6 p.

    Research output: Contribution to journal › Article

  66. PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

    Tibarewal, P., Zilidis, G., Spinelli, L., Schurch, N., Maccario, H., Gray, A., Perera, N. M., Davidson, L., Barton, G. J. & Leslie, N. R. 2012 In : Science Signaling. 5, 213, p. ra18

    Research output: Contribution to journal › Article

  67. The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser in adipocytes

    Henriksson, E., Jones, H. A., Patel, K., Peggie, M., Morrice, N., Sakamoto, K. & Göransson, O. 2012 In : Biochemical Journal. 444, 3, p. 503-514, 12 p.

    Research output: Contribution to journal › Article

  68. The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

    Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., Kemp, B. E., Sakamoto, K., Steinberg, G. R. & Hardie, D. G. 2012 In : Science.

    Research output: Contribution to journal › Article

  69. The Phenotypic Characterization of A13/BACii, a Novel Bovine Chondrocytic Cell Line with Differentiation Potential

    Qusous, A., Kaneva, M., Can, V. C., Getting, S. J. & Kerrigan, M. J. P. 2012 In : Cells tissues organs. 196, 3, p. 251-261, 11 p.

    Research output: Contribution to journal › Article

  70. Internalization of Exogenous Cystatin F Supresses Cysteine Proteases and Induces the Accumulation of Single-chain Cathepsin L by Multiple Mechanisms

    Colbert, J. D., Matthews, S. P., Kos, J. & Watts, C. 9-Dec-2011 In : Journal of Biological Chemistry. 286, 49, p. 42082-42090, 9 p.

    Research output: Contribution to journal › Article

  71. RAM/Fam103a1 is required for mRNA cap methylation

    Gonatopoulos-Pournatzis, T., Dunn, S., Bounds, R. & Cowling, V. H. 18-Nov-2011 In : Molecular Cell. 44, 4, p. 585-596, 12 p.

    Research output: Contribution to journal › Article

  72. Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability

    Ikematsu, N., Dallas, M. L., Ross, F. A., Lewis, R. W., Rafferty, J. N., David, J. A., Suman, R., Peers, C., Hardie, D. G. & Evans, A. M. 1-Nov-2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 44, p. 18132-18137, 6 p.

    Research output: Contribution to journal › Article

  73. A Multifunctional Protease Inhibitor To Regulate Endolysosomal Function

    van Kasteren, S. I., Berlin, I., Colbert, J. D., Keane, D., Ovaa, H. & Watts, C. Nov-2011 In : ACS Chemical Biology. 6, 11, p. 1198-1204, 7 p.

    Research output: Contribution to journal › Article

  74. Erratum to Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance (vol 54, pg 1596, 2011).

    Lipina, C. & Hundal, H. S. Nov-2011 In : Diabetologia. 54, 11, p. 2969-2969, 1 p.

    Research output: Contribution to journal › Article

  75. Evidence for Direct Cross-Talk between Two Essential Nutrient-Sensing Enzymes: O-GlcNAc Transferase (OGT) and AMP-activated Kinase (AMPK)

    Bullen, J., Balsbaugh, J., Neumann, D., Hardie, G., Shabanowitz, J., Hunt, D. & Hart, G. Nov-2011 In : Glycobiology. 21, 11, p. 1487-1487, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  76. Recognition of immunogold markers in electron micrographs

    Wang, R., Pokhariya, H., McKenna, S. J. & Lucocq, J. Nov-2011 In : Journal of Structural Biology. 176, 2, p. 151-158, 8 p.

    Research output: Contribution to journal › Article

  77. Early murine T-lymphocyte activation is accompanied by a switch from N-glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E

    Redelinghuys, P., Antonopoulos, A., Liu, Y., Campanero-Rhodes, M. A., McKenzie, E., Haslam, S. M., Dell, A., Feizi, T. & Crocker, P. R. 7-Oct-2011 In : Journal of Biological Chemistry. 286, 40, p. 34522-34532, 11 p.

    Research output: Contribution to journal › Article

  78. Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells

    Watson, M. L., Macrae, K., Marley, A. E. & Hundal, H. S. 5-Oct-2011 In : PLoS ONE. 6, 10, p. -, 12 p., e25975

    Research output: Contribution to journal › Article

  79. An intranucleolar body associated with rDNA

    Hutten, S., Prescott, A., James, J., Riesenberg, S., Boulon, S., Lam, Y. W. & Lamond, A. I. Oct-2011 In : Chromosoma. 120, 5, p. 481-499, 19 p.

    Research output: Contribution to journal › Article

  80. AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

    Hardie, D. G. 15-Sep-2011 In : Genes & Development. 25, 18, p. 1895-1908, 14 p.

    Research output: Contribution to journal › Scientific review

  81. Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7

    Unterholzner, L., Sumner, R. P., Baran, M., Ren, H., Mansur, D. S., Bourke, N. M., Randow, F., Smith, G. L. & Bowie, A. G. 8-Sep-2011 In : PLoS Pathogens. 7, 9, e1002247

    Research output: Contribution to journal › Article

  82. AMP-activated protein kinase: also regulated by ADP?

    Hardie, D. G., Carling, D. & Gamblin, S. J. Sep-2011 In : Trends in Biochemical Sciences. 36, 9, p. 470-477, 8 p.

    Research output: Contribution to journal › Scientific review

  83. Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet

    Jamieson, P. M., Cleasby, M. E., Kuperman, Y., Morton, N. M., Kelly, P. A. T., Brownstein, D. G., Mustard, K. J., Vaughan, J. M., Carter, R. N., Hahn, C. N., Hardie, D. G., Seckl, J. R., Chen, A. & Vale, W. W. Sep-2011 In : Diabetologia. 54, 9, p. 2392-2403, 12 p.

    Research output: Contribution to journal › Article

  84. YuaB Functions Synergistically with the Exopolysaccharide and TasA Amyloid Fibers To Allow Biofilm Formation by Bacillus subtilis

    Ostrowski, A., Mehert, A., Prescott, A., Kiley, T. B. & Stanley-Wall, N. R. Sep-2011 In : Journal of Bacteriology. 193, 18, p. 4821-4831, 11 p.

    Research output: Contribution to journal › Article

  85. Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial

    Hadad, S., Iwamoto, T., Jordan, L., Purdie, C., Bray, S., Baker, L., Jellema, G., Deharo, S., Hardie, D. G., Pusztai, L., Moulder-Thompson, S., Dewar, J. A. & Thompson, A. M. Aug-2011 In : Breast Cancer Research and Treatment. 128, 3, p. 783-794, 12 p.

    Research output: Contribution to journal › Article

  86. Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2

    Konopatskaya, O., Matthews, S. A., Harper, M. T., Gilio, K., Cosemans, J. M. E. M., Williams, C. M., Navarro, M. N., Carter, D. A., Heemskerk, J. W. M., Leitges, M., Cantrell, D. & Poole, A. W. 14-Jul-2011 In : Blood. 118, 2, p. 416-424, 9 p.

    Research output: Contribution to journal › Article

  87. TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

    Bouskila, M., Esoof, N., Gay, L., Fang, E. H., Deak, M., Begley, M. J., Cantley, L. C., Prescott, A., Storey, K. G. & Alessi, D. R. 1-Jul-2011 In : Biochemical Journal. 437, p. 157-167, 11 p.

    Research output: Contribution to journal › Article

  88. Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance

    Lipina, C. & Hundal, H. S. Jul-2011 In : Diabetologia. 54, 7, p. 1596-1607, 12 p.

    Research output: Contribution to journal › Scientific review

  89. SNAT2 transceptor signalling via mTOR: a role in cell growth and proliferation?

    Pinilla, J., Aledo, J. C., Cwiklinski, E., Hyde, R., Taylor, P. M. & Hundal, H. S. 1-Jun-2011 In : Frontiers in Bioscience (Elite Edition). E3, 4, p. 1289-1299, 11 p.

    Research output: Contribution to journal › Article

  90. AMP-activated protein kinase, a tumor suppressor that opposes the metabolic changes in cancer cells

    Hardie, D. G. Jun-2011 In : FEBS Journal. 278, s1, p. 41-42, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  91. Innate DNA sensing moves to the nucleus

    Unterholzner, L. & Bowie, A. G. 19-May-2011 9, 5, p. 351-353, 3 p.

    Research output: Contribution to journal › Article

  92. A Systemic Lupus Erythematosus-associated R77H Substitution in the CD11b Chain of the Mac-1 Integrin Compromises Leukocyte Adhesion and Phagocytosis

    MacPherson, M., Lek, H. S., Prescott, A. & Fagerholm, S. C. 13-May-2011 In : Journal of Biological Chemistry. 286, 19, p. 17303-17310, 8 p.

    Research output: Contribution to journal › Article

  93. Proteomic tools for the analysis of transient interactions between metalloproteins

    Martínez-Fábregas, J., Rubio, S., Díaz-Quintana, A., Díaz-Moreno, I. & De La Rosa, M. A. 1-May-2011 In : FEBS Journal. 278, 9, p. 1401-1410, 10 p.

    Research output: Contribution to journal › Article

  94. Asparagine endopeptidase is required for normal kidney physiology and homeostasis

    Miller, G., Matthews, S. P., Reinheckel, T., Fleming, S. & Watts, C. May-2011 In : FASEB Journal. 25, 5, p. 1606-1617, 12 p.

    Research output: Contribution to journal › Article

  95. Homeostasis in the vertebrate lens: mechanisms of solute exchange

    Dahm, R., van Marle, J., Quinlan, R. A., Prescott, A. R. & Vrensen, G. F. J. M. 27-Apr-2011 In : Philosophical Transactions of the Royal Society B - Biological Sciences. 366, 1568, p. 1265-1277, 13 p.

    Research output: Contribution to journal › Scientific review

  96. Intracellular ATP Influences Synaptic Plasticity in Area CA1 of Rat Hippocampus via Metabolism to Adenosine and Activity-Dependent Activation of Adenosine A(1) Receptors

    zur Nedden, S., Hawley, S., Pentland, N., Hardie, D. G., Doney, A. S. & Frenguelli, B. 20-Apr-2011 In : Journal of Neuroscience. 31, 16, p. 6221-6234, 14 p.

    Research output: Contribution to journal › Article

  97. Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor kappa B signalling in rat skeletal muscle cells by AMP-activated protein kinase

    Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, K. & Hundal, H. S. 15-Apr-2011 In : Biochemical Journal. 435, p. 463-474, 12 p.

    Research output: Contribution to journal › Article

  98. Signal transduction: how cells sense energy

    Hardie, D. G. 14-Apr-2011 In : Nature. 472, 7342, p. 176-177, 2 p.

    Research output: Contribution to journal › Editorial

  99. Selective Expression in Carotid Body Type I Cells of a Single Splice Variant of the Large Conductance Calcium- and Voltage-activated Potassium Channel Confers Regulation by AMP-activated Protein Kinase

    Ross, F. A., Rafferty, J. N., Dallas, M. L., Ogunbayo, O., Ikematsu, N., McClafferty, H., Tian, L., Widmer, H., Rowe, I. C. M., Wyatt, C. N., Shipston, M. J., Peers, C., Hardie, D. G. & Evans, A. M. 8-Apr-2011 In : Journal of Biological Chemistry. 286, 14, p. 11929-11936, 8 p.

    Research output: Contribution to journal › Article

  100. A Screen for Novel Phosphoinositide 3-kinase Effector Proteins

    Dixon, M. J., Gray, A., Boisvert, F-M., Agacan, M., Morrice, N. A., Gourlay, R., Leslie, N. R., Downes, C. P. & Batty, I. H. Apr-2011 In : Molecular & Cellular Proteomics. 10, 4, p. -, 13 p., 003178

    Research output: Contribution to journal › Article

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