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Cell Signalling & Immunology

  1. The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels

    Hawley, S., Ford, R. J., Smith, B. K., Gowans, G., Mancini, S. J., Pitt, R. D., A. Day, E., Salt, I. P., Steinberg, G. R. & Hardie, D. G. Sep 2016 In : Diabetes. 65, 9, p. 2784-2794 11 p.

    Research output: Contribution to journalArticle

  2. Glycoproteomic studies of IgE from a novel hyper IgE syndrome linked to PGM3 mutation

    Wu, G., Hitchen, P. G., Panico, M., North, S. J., Barbouche, M-R., Binet, D., Morris, H. R., Dell, A. & Haslam, S. M. Jun 2016 In : Glycoconjugate Journal. 33, 3, p. 447-456 10 p.

    Research output: Contribution to journalArticle

  3. Iron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD

    Watson, A., Lipina, C., McArdle, H. J., Taylor, P. M. & Hundal, H. May 2016 In : Cellular Signalling. 28, 5, p. 412-424

    Research output: Contribution to journalArticle

  4. Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling

    Zhou, Z., Tang, A. T., Wong, W. Y., Bamezai, S., Goddard, L. M., Shenkar, R., Zhou, S., Yang, J., Wright, A. C., Foley, M., Arthur, J. S. C., Whitehead, K. J., Awad, I. A., Li, D. Y., Zheng, X. & Kahn, M. L. 7 Apr 2016 In : Nature. 532, 7597, p. 122-126 5 p., 17178

    Research output: Contribution to journalArticle

  5. The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway

    Bailly, A., Perrin, A., Bou Malhab, L. J., Pion, E., Larance, M., Nagala, M., Smith, P., O'Donohue, M-F., Gleizes, P-E., Zomerdijk, J., Lamond, A. I. & Xirodimas, D. P. 28 Jan 2016 In : Oncogene. 35, 4, p. 415-426 12 p.

    Research output: Contribution to journalArticle

  6. Sialylation and immune surveillance of cancer by siglecs

    Crocker, P. R. & Mohan, B. 27 Jan 2016 Glycosignals in Cancer: Mechanisms of Malignant Phenotypes. p. 125-138 14 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  7. The cytotoxic T cell proteome and its shaping by the kinase mTOR

    Hukelmann, J. L., Anderson, K. E., Sinclair, L. V., Grzes, K. M., Brenes Murillo, A., Hawkins, P. T., Stephens, L. R., Lamond, A. I. & Cantrell, D. A. Jan 2016 In : Nature Immunology. 17, 1, p. 104-112 9 p.

    Research output: Contribution to journalArticle

  8. A key role for PTP1B in dendritic cell maturation, migration, and T cell activation

    Martin-Granados, C., Prescott, A. R., Le Sommer, S., Klaska, I. P., Yu, T., Muckersie, E., Giuraniuc, C. V., Grant, L., Delibegovic, M. & Forrester, J. V. Dec 2015 In : Journal of Molecular Cell Biology. 7, 6, p. 517-528 12 p.

    Research output: Contribution to journalArticle

  9. Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2

    Lang, E., Bissinger, R., Fajol, A., Salker, M. S., Singh, Y., Zelenak, C., Ghashghaeinia, M., Gu, S., Jilani, K., Lupescu, A., Reyskens, K. M. S. E., Ackermann, T. F., Föller, M., Schleicher, E., Sheffield, W. P., Arthur, J. S. C., Lang, F. & Qadri, S. M. 27 Nov 2015 In : Scientific Reports. 5, p. 1-10 10 p., 17316

    Research output: Contribution to journalArticle

  10. GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling

    Stretton, C., Hoffmann, T. M., Munson, M. J., Prescott, A., Taylor, P. M., Ganley, I. G. & Hundal, H. 1 Sep 2015 In : Biochemical Journal. 470, 2, p. 207-221

    Research output: Contribution to journalArticle

  11. NEU3 sialidase as a marker of insulin sensitivity: Regulation by fatty acids

    Lipina, C., Nardi, F., Grace, H. & Hundal, H. S. 1 Sep 2015 In : Cellular Signalling. 27, 9, p. 1742-1750 9 p.

    Research output: Contribution to journalArticle

  12. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

    Preston, G. C., Sinclair, L. V., Kaskar, A., Hukelmann, J. L., Navarro, M., Ferrero, I., MacDonald, H. R., Cowling, V. H. & Cantrell, D. A. 4 Aug 2015 In : EMBO Journal. 34, 15, p. 2008-2024 17 p.

    Research output: Contribution to journalArticle

  13. Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

    Kazlauskaite, A., Martínez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H. & Muqit, M. M. K. 1 Aug 2015 In : EMBO Reports. 16, 8, p. 939-954 16 p.

    Research output: Contribution to journalArticle

  14. Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α

    Rog-Zielinska, E. A., Craig, M. A., Manning, J. R., Richardson, R. V., Gowans, G. J., Dunbar, D. R., Gharbi, K., Kenyon, C. J., Holmes, M. C., Hardie, D. G., Smith, G. L. & Chapman, K. E. 1 Jul 2015 In : Cell Death & Differentiation. 22, 7, p. 1106-1116 11 p.

    Research output: Contribution to journalArticle

  15. AMPK dilates resistance arteries via activation of SERCA and BKCa channels in smooth muscle

    Schneider, H., Schubert, K. M., Blodow, S., Kreutz, C-P., Erdogmus, S., Wiedenmann, M., Qiu, J., Fey, T., Ruth, P., Lubomirov, L. T., Pfitzer, G., Mederos y Schnitzler, M., Hardie, D. G., Gudermann, T. & Pohl, U. Jul 2015 In : Hypertension. 66, 1, p. 108-116 9 p.

    Research output: Contribution to journalArticle

  16. Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members

    Malik, N., Vollmer, S., Nanda, S. K., Lopez-Pelaez, M., Prescott, A., Gray, N. & Cohen, P. 15 Jun 2015 In : Biochemical Journal. 468, 3, p. 363-372 10 p.

    Research output: Contribution to journalArticle

  17. Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance

    Swamy, M., Abeler-Dörner, L., Chettle, J., Mahlakõiv, T., Goubau, D., Chakravarty, P., Ramsay, G., Reis e Sousa, C., Staeheli, P., Blacklaws, B. A., Heeney, J. L. & Hayday, A. C. 19 May 2015 In : Nature Communications. 6, 12 p., 7090

    Research output: Contribution to journalArticle

  18. PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

    Jensen, T. E., Ross, F. A., Kleinert, M., Sylow, L., Knudsen, J. R., Gowans, G. J., Hardie, D. G. & Richter, E. A. May 2015 In : Biochemical Journal. 467, 3, p. 461-472 12 p.

    Research output: Contribution to journalArticle

  19. AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

    Hardie, D. G. Apr 2015 In : Current Opinion in Cell Biology. 33, April, p. 1-7 7 p.

    Research output: Contribution to journalReview article

  20. Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability

    Nardi, F., Hoffmann, T. M., Stretton, C., Cwiklinski, E., Taylor, P. M. & Hundal, H. S. 27 Mar 2015 In : Journal of Biological Chemistry. 290, 13, p. 8173-8184 12 p.

    Research output: Contribution to journalArticle

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