Cell Signalling & Immunology

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y-B., Taylor, P. M. & Cantrell, D. A. May-2013 In : Nature Immunology. 14, 5, p. 500-508, 9 p.

Research output: Contribution to journal › Article

PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3-Apr-2013 In : EMBO Journal. 32, 7, p. 1008-22, 15 p.

Research output: Contribution to journal › Article

AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

Dandapani, M. & Hardie, D. G. Apr-2013 In : Biochemical Society Transactions. 41, 2, p. 687-693, 7 p.

Research output: Contribution to journal › Article

Dectin-1 Regulates IL-10 Production via a MSK1/2 and CREB Dependent Pathway and Promotes the Induction of Regulatory Macrophage Markers

Elcombe, S. E., Naqvi, S., Van den Bosch, M. W. M., MacKenzie, K. F., Cianfanelli, F., Brown, G. D. & Arthur, J. S. C. 22-Mar-2013 In : PLoS ONE. 8, 3, 15 p., e60086

Research output: Contribution to journal › Article

LKB1 Mediates the Development of Conventional and Innate T Cells via AMP-Dependent Kinase Autonomous Pathways

Zarrouk, M., Rolf, J. & Cantrell, D. A. 22-Mar-2013 In : PLoS ONE. 8, 3, 9 p., e60217

Research output: Contribution to journal › Article

Sialoadhesin ligand expression identifies a subpopulation of Foxp3- T cells with a distinct activation and glycosylation profile

Kidder, D., Richards, H. E., Ziltener, H. J., Garden, O. A. & Crocker, P. R. 15-Mar-2013 In : Journal of Immunology. 190, 6, p. 2593-2602, 10 p.

Research output: Contribution to journal › Article

Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b beta2-integrin-dependent signalling

McMillan, S. J., Sharma, R. S., McKenzie, E. J., Richards, H. E., Zhang, J., Prescott, A. & Crocker, P. R. 14-Mar-2013 In : Blood. 121, 11, p. 2084-2094, 11 p.

Research output: Contribution to journal › Article

Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors

Horan, K. A., Hansen, K., Jakobsen, M. R., Holm, C. K., Søby, S., Unterholzner, L., Thompson, M., West, J. A., Iversen, M. B., Rasmussen, S. B., Ellermann-Eriksen, S., Kurt-Jones, E., Landolfo, S., Damania, B., Melchjorsen, J., Bowie, A. G., Fitzgerald, K. A. & Paludan, S. R. 1-Mar-2013 In : Journal of Immunology. 190, 5, p. 2311-2319, 9 p.

Research output: Contribution to journal › Article

Hormonal regulation of the Salt-inducible Kinase (SIK), a key mediator that controls hepatic gluconeogenesis

Patel, K., Goransson, O., Sutherland, C. & Sakamoto, K. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. E2-E2, 1 p., P577

Research output: Contribution to journal › Meeting abstract

Insulin sensitising effects of monounsaturated and polyunsaturated fatty acids in skeletal muscle cells

Nardi, F., Lipina, C., Magill, D. & Hundal, H. S. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. 49-49, 1 p., P70

Research output: Contribution to journal › Meeting abstract

Obesity-Induced Insulin Resistance in Human Skeletal Muscle Is Characterised by Defective Activation of p42/p44 MAP Kinase

Ruiz-Alcaraz, A. J., Lipina, C., Petrie, J. R., Murphy, M. J., Morris, A. D., Sutherland, C. & Cuthbertson, D. J. 28-Feb-2013 In : PLoS ONE. 8, 2, e56928

Research output: Contribution to journal › Article

Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence

Mansur, D. S., Maluquer de Motes, C., Unterholzner, L., Sumner, R. P., Ferguson, B. J., Ren, H., Strnadova, P., Bowie, A. G. & Smith, G. L. 28-Feb-2013 In : PLoS Pathogens. 9, 2, e1003183

Research output: Contribution to journal › Article

Metabolism of inflammation limited by AMPK and pseudo-starvation

O'Neill, L. A. J. & Hardie, D. G. 17-Jan-2013 In : Nature. 493, 7432, p. 346-355, 10 p.

Research output: Contribution to journal › Article

PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway

Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15-Jan-2013 In : Journal of Immunology. 190, 2, p. 565-77, 13 p.

Research output: Contribution to journal › Article

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S. & Tauro, S. 1-Jan-2013 In : Scientific Reports. 3, 1275

Research output: Contribution to journal › Article

Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo

Belch, J. J. F., Akbar, N., Alapati, V., Petrie, J., Arthur, S. & Khan, F. Jan-2013 In : Microvascular Research. 85, p. 86-92, 7 p.

Research output: Contribution to journal › Article

The role of amino acid transporters in nutrition

Poncet, N. & Taylor, P. M. Jan-2013 In : Current Opinion in Clinical Nutrition and Metabolic Care. 16, 1, p. 57-65, 9 p.

Research output: Contribution to journal › Article

Chronic exposure of astrocytes to interferon-alpha reveals molecular changes related to Aicardi-Goutieres syndrome

Cuadrado, E., Jansen, M. H., Anink, J., De Filippis, L., Vescovi, A. L., Watts, C., Aronica, E., Hol, E. M. & Kuijpers, T. W. 2013 In : Brain. 136, 1, p. 245-258, 14 p.

Research output: Contribution to journal › Article