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Cell Signalling & Immunology

  1. AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

    Hardie, D. G. Apr 2015 In : Current Opinion in Cell Biology. 33, April, p. 1-7 7 p.

    Research output: Contribution to journalArticle

  2. Proteasomal Modulation of Cellular SNAT2 (SLC38A2) Abundance and Function by Unsaturated Fatty Acid Availability

    Nardi, F., Hoffmann, T. M., Stretton, C., Cwiklinski, E., Taylor, P. M. & Hundal, H. S. 27 Mar 2015 In : Journal of Biological Chemistry. 290, 13, p. 8173-8184 12 p.

    Research output: Contribution to journalArticle

  3. SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation

    Varshney, D., Vavrova-Anderson, J., Oler, A. J., Cowling, V. H., Cairns, B. R. & White, R. J. 23 Mar 2015 In : Nature Communications. 6, 12 p.6569

    Research output: Contribution to journalArticle

  4. Identification of caveolar resident proteins in ventricular myocytes using a quantitative proteomic approach: dynamic changes in caveolar composition following adrenoceptor activation

    Wypijewski, K. J., Tinti, M., Chen, W., Lamont, D., Ashford, M. L. J., Calaghan, S. C. & Fuller, W. Mar 2015 In : Molecular & Cellular Proteomics. 14, 3, p. 596-608 13 p.

    Research output: Contribution to journalArticle

  5. ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation

    Stone, E. L., Pepper, M., Katayama, C. D., Kerdiles, Y. M., Lai, C-Y., Emslie, E., Lin, Y. C., Yang, E., Goldrath, A. W., Li, M. O., Cantrell, D. A. & Hedrick, S. M. 17 Feb 2015 In : Immunity. 42, 2, p. 239-251 13 p.

    Research output: Contribution to journalArticle

  6. Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation

    Pirkmajer, S., Kulkarni, S. S., Tom, R. Z., Ross, F. A., Hawley, S. A., Hardie, D. G., Zierath, J. R. & Chibalin, A. V. Feb 2015 In : Diabetes. 64, 2, p. 360-369 10 p.

    Research output: Contribution to journalArticle

  7. Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis

    Karelina, K., Liu, Y., Alzate-Correa, D., Wheaton, K. L., Hoyt, K. R., Arthur, J. S. C. & Obrietan, K. 29 Jan 2015 In : Neuroscience. 285, p. 292-302 11 p.

    Research output: Contribution to journalArticle

  8. RAB1A promotes Vaccinia virus replication by facilitating the production of intracellular enveloped virions

    Pechenick Jowers, T., Featherstone, R. J., Reynolds, D. K., Brown, H. K., James, J., Prescott, A., Haga, I. R. & Beard, P. M. 15 Jan 2015 In : Virology. 475, p. 66-73 8 p.

    Research output: Contribution to journalArticle

  9. The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases

    Ozanne, J., Prescott, A. R. & Clark, K. 15 Jan 2015 In : Biochemical Journal. 465, 2, p. 271-279 9 p.

    Research output: Contribution to journalArticle

  10. PTEN inhibitors: an evaluation of current compounds

    Spinelli, L., Lindsay, Y. E. & Leslie, N. R. Jan 2015 In : Advances in Biological Regulation. 57, p. 102-111 10 p.

    Research output: Contribution to journalArticle

  11. High-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow-derived macrophages

    Guo, M., Härtlova, A., Dill, B. D., Prescott, A. R., Gierliński, M. & Trost, M. 2015 In : Proteomics. 12 p.

    Research output: Contribution to journalArticle

  12. Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes

    Spinelli, L., Black, F. M., Berg, J. N., Eickholt, B. J. & Leslie, N. R. 19 Dec 2014 In : Journal of Medical Genetics.

    Research output: Contribution to journalArticle

  13. Substrate recognition by the cell surface palmitoyl transferase DHHC5

    Howie, J., Reilly, L., Fraser, N. J., Vlachaki Walker, J., Wypijewski, . K. J., Ashford, M. L. J., Calaghan, S., McClafferty, H., Tian, L., Shipston, M. J., Boguslavskyi, A., Shattock, M. J. & Fuller, W. 9 Dec 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 49, p. 17534-17539 6 p.

    Research output: Contribution to journalArticle

  14. AMPK-sensing energy while talking to other signaling pathways

    Hardie, D. G. 2 Dec 2014 In : Cell Metabolism. 20, 6, p. 939-952 14 p.

    Research output: Contribution to journalArticle

  15. AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

    Hardie, D. G. Dec 2014 In : Journal of Internal Medicine. 276, 6, p. 543-559 17 p.

    Research output: Contribution to journalArticle

  16. Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks

    Navarro, M. N., Goebel, J., Hukelmann, J. L. & Cantrell, D. A. Dec 2014 In : Molecular & Cellular Proteomics. 13, 12, p. 3544-3557 14 p.

    Research output: Contribution to journalArticle

  17. Pseudaminic acid on Campylobacter jejuni flagella modulates dendritic cell IL-10 expression via Siglec-10 receptor: a novel flagellin-host interaction

    Stephenson, H. N., Mills, D. C., Jones, H., Milioris, E., Copland, A., Dorrell, N., Wren, B. W., Crocker, P. R., Escors, D. & Bajaj-Elliott, M. 1 Nov 2014 In : Journal of Infectious Diseases. 210, 9, p. 1487-1498 12 p.

    Research output: Contribution to journalArticle

  18. Carnosic acid stimulates glucose uptake in skeletal muscle cells via a PME-1/PP2A/PKB signalling axis

    Lipina, C. & Hundal, H. S. Nov 2014 In : Cellular Signalling. 26, 11, p. 2343-2349 6 p.

    Research output: Contribution to journalArticle

  19. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

    Bago, R., Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G. & Alessi, D. R. Nov 2014 In : Biochemical Journal. 463, 3, p. 413-427 15 p.

    Research output: Contribution to journalArticle

  20. Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype

    Morrison, V. L., James, M. J., Grzes, K., Cook, P., Glass, D. G., Savinko, T., Lek, H. S., Gawden-Bone, C., Watts, C., Millington, O. R., MacDonald, A. S. & Fagerholm, S. C. 28 Oct 2014 In : Nature Communications. 5, 13 p.5359

    Research output: Contribution to journalArticle

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