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Cell Signalling & Immunology

  1. Iron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD

    Watson, A., Lipina, C., McArdle, H. J., Taylor, P. M. & Hundal, H. May 2016 In : Cellular Signalling. 28, 5, p. 412-424

    Research output: Contribution to journalArticle

  2. Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling

    Zhou, Z., Tang, A. T., Wong, W. Y., Bamezai, S., Goddard, L. M., Shenkar, R., Zhou, S., Yang, J., Wright, A. C., Foley, M., Arthur, J. S. C., Whitehead, K. J., Awad, I. A., Li, D. Y., Zheng, X. & Kahn, M. L. 7 Apr 2016 In : Nature. 532, 7597, p. 122-126 5 p., 17178

    Research output: Contribution to journalArticle

  3. Sialylation and immune surveillance of cancer by siglecs

    Crocker, P. R. & Mohan, B. 27 Jan 2016 Glycosignals in Cancer: Mechanisms of Malignant Phenotypes. p. 125-138 14 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  4. The cytotoxic T cell proteome and its shaping by the kinase mTOR

    Hukelmann, J. L., Anderson, K. E., Sinclair, L. V., Grzes, K. M., Brenes Murillo, A., Hawkins, P. T., Stephens, L. R., Lamond, A. I. & Cantrell, D. A. Jan 2016 In : Nature Immunology. 17, 1, p. 104-112 9 p.

    Research output: Contribution to journalArticle

  5. The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway

    Bailly, A., Perrin, A., Bou Malhab, L. J., Pion, E., Larance, M., Nagala, M., Smith, P., O'Donohue, M-F., Gleizes, P-E., Zomerdijk, J., Lamond, A. I. & Xirodimas, D. P. 2016 In : Oncogene. 35, p. 415-426 12 p.

    Research output: Contribution to journalArticle

  6. Glycoproteomic studies of IgE from a novel hyper IgE syndrome linked to PGM3 mutation

    Wu, G., Hitchen, P. G., Panico, M., North, S. J., Barbouche, M-R., Binet, D., Morris, H. R., Dell, A. & Haslam, S. M. 19 Dec 2015 In : Glycoconjugate Journal. p. 1-10 10 p.

    Research output: Contribution to journalArticle

  7. GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling

    Stretton, C., Hoffmann, T. M., Munson, M. J., Prescott, A., Taylor, P. M., Ganley, I. G. & Hundal, H. 1 Sep 2015 In : Biochemical Journal. 470, 2, p. 207-221

    Research output: Contribution to journalArticle

  8. NEU3 sialidase as a marker of insulin sensitivity: Regulation by fatty acids

    Lipina, C., Nardi, F., Grace, H. & Hundal, H. S. 1 Sep 2015 In : Cellular Signalling. 27, 9, p. 1742-1750 9 p.

    Research output: Contribution to journalArticle

  9. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

    Preston, G. C., Sinclair, L. V., Kaskar, A., Hukelmann, J. L., Navarro, M., Ferrero, I., MacDonald, H. R., Cowling, V. H. & Cantrell, D. A. 4 Aug 2015 In : EMBO Journal. 34, 15, p. 2008-2024 17 p.

    Research output: Contribution to journalArticle

  10. Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

    Kazlauskaite, A., Martínez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H. & Muqit, M. M. K. 1 Aug 2015 In : EMBO Reports. 16, 8, p. 939-954 16 p.

    Research output: Contribution to journalArticle

  11. Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α

    Rog-Zielinska, E. A., Craig, M. A., Manning, J. R., Richardson, R. V., Gowans, G. J., Dunbar, D. R., Gharbi, K., Kenyon, C. J., Holmes, M. C., Hardie, D. G., Smith, G. L. & Chapman, K. E. 1 Jul 2015 In : Cell Death & Differentiation. 22, 7, p. 1106-1116 11 p.

    Research output: Contribution to journalArticle

  12. AMPK dilates resistance arteries via activation of SERCA and BKCa channels in smooth muscle

    Schneider, H., Schubert, K. M., Blodow, S., Kreutz, C-P., Erdogmus, S., Wiedenmann, M., Qiu, J., Fey, T., Ruth, P., Lubomirov, L. T., Pfitzer, G., Mederos y Schnitzler, M., Hardie, D. G., Gudermann, T. & Pohl, U. Jul 2015 In : Hypertension. 66, 1, p. 108-116 9 p.

    Research output: Contribution to journalArticle

  13. Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members

    Malik, N., Vollmer, S., Nanda, S. K., Lopez-Pelaez, M., Prescott, A., Gray, N. & Cohen, P. 15 Jun 2015 In : Biochemical Journal. 468, 3, p. 363-372 10 p.

    Research output: Contribution to journalArticle

  14. Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance

    Swamy, M., Abeler-Dörner, L., Chettle, J., Mahlakõiv, T., Goubau, D., Chakravarty, P., Ramsay, G., Reis e Sousa, C., Staeheli, P., Blacklaws, B. A., Heeney, J. L. & Hayday, A. C. 19 May 2015 In : Nature Communications. 6, 12 p., 7090

    Research output: Contribution to journalArticle

  15. PT-1 selectively activates AMPK-γ 1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

    Jensen, T. E., Ross, F. A., Kleinert, M., Sylow, L., Knudsen, J. R., Gowans, G. J., Hardie, D. G. & Richter, E. A. May 2015 In : Biochemical Journal. 467, 3, p. 461-472 12 p.

    Research output: Contribution to journalArticle

  16. AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

    Hardie, D. G. Apr 2015 In : Current Opinion in Cell Biology. 33, April, p. 1-7 7 p.

    Research output: Contribution to journalArticle

  17. Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability

    Nardi, F., Hoffmann, T. M., Stretton, C., Cwiklinski, E., Taylor, P. M. & Hundal, H. S. 27 Mar 2015 In : Journal of Biological Chemistry. 290, 13, p. 8173-8184 12 p.

    Research output: Contribution to journalArticle

  18. SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation

    Varshney, D., Vavrova-Anderson, J., Oler, A. J., Cowling, V. H., Cairns, B. R. & White, R. J. 23 Mar 2015 In : Nature Communications. 6, 12 p., 6569

    Research output: Contribution to journalArticle

  19. Identification of caveolar resident proteins in ventricular myocytes using a quantitative proteomic approach: dynamic changes in caveolar composition following adrenoceptor activation

    Wypijewski, K. J., Tinti, M., Chen, W., Lamont, D., Ashford, M. L. J., Calaghan, S. C. & Fuller, W. Mar 2015 In : Molecular & Cellular Proteomics. 14, 3, p. 596-608 13 p.

    Research output: Contribution to journalArticle

  20. ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation

    Stone, E. L., Pepper, M., Katayama, C. D., Kerdiles, Y. M., Lai, C-Y., Emslie, E., Lin, Y. C., Yang, E., Goldrath, A. W., Li, M. O., Cantrell, D. A. & Hedrick, S. M. 17 Feb 2015 In : Immunity. 42, 2, p. 239-251 13 p.

    Research output: Contribution to journalArticle

  21. Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes

    Spinelli, L., Black, F. M., Berg, J. N., Eickholt, B. J. & Leslie, N. R. Feb 2015 In : Journal of Medical Genetics. 52, 2, p. 128-134 7 p.

    Research output: Contribution to journalArticle

  22. Idiopathic hypocomplementemic interstitial nephritis

    Kidder, D., Stewart, G. A., Furrie, E. & Fleming, S. Feb 2015 In : Kidney International. 87, 2, p. 485-486 2 p.

    Research output: Contribution to journalArticle

  23. Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation

    Pirkmajer, S., Kulkarni, S. S., Tom, R. Z., Ross, F. A., Hawley, S. A., Hardie, D. G., Zierath, J. R. & Chibalin, A. V. Feb 2015 In : Diabetes. 64, 2, p. 360-369 10 p.

    Research output: Contribution to journalArticle

  24. Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis

    Karelina, K., Liu, Y., Alzate-Correa, D., Wheaton, K. L., Hoyt, K. R., Arthur, J. S. C. & Obrietan, K. 29 Jan 2015 In : Neuroscience. 285, p. 292-302 11 p.

    Research output: Contribution to journalArticle

  25. RAB1A promotes Vaccinia virus replication by facilitating the production of intracellular enveloped virions

    Pechenick Jowers, T., Featherstone, R. J., Reynolds, D. K., Brown, H. K., James, J., Prescott, A., Haga, I. R. & Beard, P. M. 15 Jan 2015 In : Virology. 475, p. 66-73 8 p.

    Research output: Contribution to journalArticle

  26. The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases

    Ozanne, J., Prescott, A. R. & Clark, K. 15 Jan 2015 In : Biochemical Journal. 465, 2, p. 271-279 9 p.

    Research output: Contribution to journalArticle

  27. PTEN inhibitors: an evaluation of current compounds

    Spinelli, L., Lindsay, Y. E. & Leslie, N. R. Jan 2015 In : Advances in Biological Regulation. 57, p. 102-111 10 p.

    Research output: Contribution to journalArticle

  28. Environmental and metabolic sensors that control T cell biology

    Ramsay, G. & Cantrell, D. 2015 In : Frontiers in Immunology. 6, 8 p., 99

    Research output: Contribution to journalArticle

  29. Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling

    Reilly, L., Howie, J., Wypijewski, K., Ashford, M. L. J., Hilgemann, D. W. & Fuller, W. 2015 In : FASEB Journal. 12 p.

    Research output: Contribution to journalArticle

  30. Substrate recognition by the cell surface palmitoyl transferase DHHC5

    Howie, J., Reilly, L., Fraser, N. J., Vlachaki Walker, J., Wypijewski, . K. J., Ashford, M. L. J., Calaghan, S., McClafferty, H., Tian, L., Shipston, M. J., Boguslavskyi, A., Shattock, M. J. & Fuller, W. 9 Dec 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 49, p. 17534-17539 6 p.

    Research output: Contribution to journalArticle

  31. AMPK-sensing energy while talking to other signaling pathways

    Hardie, D. G. 2 Dec 2014 In : Cell Metabolism. 20, 6, p. 939-952 14 p.

    Research output: Contribution to journalArticle

  32. AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

    Hardie, D. G. Dec 2014 In : Journal of Internal Medicine. 276, 6, p. 543-559 17 p.

    Research output: Contribution to journalArticle

  33. Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks

    Navarro, M. N., Goebel, J., Hukelmann, J. L. & Cantrell, D. A. Dec 2014 In : Molecular & Cellular Proteomics. 13, 12, p. 3544-3557 14 p.

    Research output: Contribution to journalArticle

  34. Pseudaminic acid on Campylobacter jejuni flagella modulates dendritic cell IL-10 expression via Siglec-10 receptor: a novel flagellin-host interaction

    Stephenson, H. N., Mills, D. C., Jones, H., Milioris, E., Copland, A., Dorrell, N., Wren, B. W., Crocker, P. R., Escors, D. & Bajaj-Elliott, M. 1 Nov 2014 In : Journal of Infectious Diseases. 210, 9, p. 1487-1498 12 p.

    Research output: Contribution to journalArticle

  35. Carnosic acid stimulates glucose uptake in skeletal muscle cells via a PME-1/PP2A/PKB signalling axis

    Lipina, C. & Hundal, H. S. Nov 2014 In : Cellular Signalling. 26, 11, p. 2343-2349 6 p.

    Research output: Contribution to journalArticle

  36. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

    Bago, R., Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G. & Alessi, D. R. Nov 2014 In : Biochemical Journal. 463, 3, p. 413-427 15 p.

    Research output: Contribution to journalArticle

  37. Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype

    Morrison, V. L., James, M. J., Grzes, K., Cook, P., Glass, D. G., Savinko, T., Lek, H. S., Gawden-Bone, C., Watts, C., Millington, O. R., MacDonald, A. S. & Fagerholm, S. C. 28 Oct 2014 In : Nature Communications. 5, 13 p., 5359

    Research output: Contribution to journalArticle

  38. A crucial role for β2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells

    Gawden-Bone, C., West, M. A., Morrison, V. L., Edgar, A. J., McMillan, S. J., Dill, B. D., Trost, M., Prescott, A., Fagerholm, S. C. & Watts, C. 1 Oct 2014 In : Journal of Cell Science. 127, 19, p. 4213-4224 12 p.

    Research output: Contribution to journalArticle

  39. Siglec-mediated regulation of immune cell function in disease

    Macauley, M. S., Crocker, P. R. & Paulson, J. C. Oct 2014 In : Nature Reviews Immunology. 14, 10, p. 653-666 14 p.

    Research output: Contribution to journalArticle

  40. Valuation of hospital bed-days released by infection control programs: a comparison of methods

    Stewardson, A. J., Harbarth, S., Graves, N. & TIMBER Study Group Oct 2014 In : Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America. 35, 10, p. 1294-1297 4 p.

    Research output: Contribution to journalArticle

  41. Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells

    Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A. 2 Sep 2014 In : PLoS ONE. 9, 9, 7 p., e106710

    Research output: Contribution to journalArticle

  42. Introduction to special issue: 'emerging roles of siglecs in health and disease'

    Crocker, P. R. & Kannagi, R. Sep 2014 In : Glycobiology. 24, 9, p. 784-784 1 p.

    Research output: Contribution to journalArticle

  43. Peripheral prion disease pathogenesis is unaltered in the absence of sialoadhesin (Siglec-1/CD169)

    Bradford, B. M., Crocker, P. R. & Mabbott, N. A. Sep 2014 In : Immunology. 143, 1, p. 120-129 10 p.

    Research output: Contribution to journalArticle

  44. Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus

    Chang, Y-C., Olson, J., Louie, A., Crocker, P. R., Varki, A. & Nizet, V. Sep 2014 In : Journal of Molecular Medicine. 92, 9, p. 951-959 9 p.

    Research output: Contribution to journalArticle

  45. Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insight

    Mahfouz, R., Khoury, R., Blachnio-Zabielska, A., Turban, S., Loiseau, N., Lipina, C., Stretton, C., Bourron, O., Ferré, P., Foufelle, F., Hundal, H. S. & Hajduch, E. 24 Jul 2014 In : PLoS ONE. 9, 7, 9 p., e101865

    Research output: Contribution to journalArticle

  46. Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung

    McMillan, S. J., Sharma, R. S., Richards, H. E., Hegde, V. & Crocker, P. R. 18 Jul 2014 In : Journal of Biological Chemistry. 289, 29, p. 20370-20376 7 p.

    Research output: Contribution to journalArticle

  47. Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase

    Banerjee, S., Zagorska, A., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R. 15 Jul 2014 In : Biochemical Journal. 461, 2, p. 233-245 13 p.

    Research output: Contribution to journalArticle

  48. Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system?

    Lipina, C., Irving, A. J. & Hundal, H. S. 1 Jul 2014 In : American Journal of Physiology, Endocrinology and Metabolism. 307, 1, p. E1-E13

    Research output: Contribution to journalArticle

  49. PDK1 controls upstream PI3K expression and PIP3 generation

    Dieterle, A. M., Böhler, P., Keppeler, H., Alers, S., Berleth, N., Drießen, S., Hieke, N., Pietkiewicz, S., Löffler, A. S., Peter, C., Gray, A., Leslie, N. R., Shinohara, H., Kurosaki, T., Engelke, M., Wienands, J., Bonin, M., Wesselborg, S. & Stork, B. 5 Jun 2014 In : Oncogene. 33, 23, p. 3043-3053 11 p.

    Research output: Contribution to journalArticle

  50. High-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC proteomics

    Güther, M. L. S., Urbaniak, M. D., Tavendale, A., Prescott, A. & Ferguson, M. A. J. Jun 2014 In : Journal of Proteome Research. 13, 6, p. 2796-2806 11 p.

    Research output: Contribution to journalArticle

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