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  1. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

    Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y-B., Taylor, P. M. & Cantrell, D. A. May-2013 In : Nature Immunology. 14, 5, p. 500-508, 9 p.

    Research output: Contribution to journal › Article

  2. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

    Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3-Apr-2013 In : EMBO Journal. 32, 7, p. 1008-22, 15 p.

    Research output: Contribution to journal › Article

  3. AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

    Dandapani, M. & Hardie, D. G. Apr-2013 In : Biochemical Society Transactions. 41, 2, p. 687-693, 7 p.

    Research output: Contribution to journal › Article

  4. Dectin-1 Regulates IL-10 Production via a MSK1/2 and CREB Dependent Pathway and Promotes the Induction of Regulatory Macrophage Markers

    Elcombe, S. E., Naqvi, S., Van den Bosch, M. W. M., MacKenzie, K. F., Cianfanelli, F., Brown, G. D. & Arthur, J. S. C. 22-Mar-2013 In : PLoS ONE. 8, 3, 15 p., e60086

    Research output: Contribution to journal › Article

  5. LKB1 Mediates the Development of Conventional and Innate T Cells via AMP-Dependent Kinase Autonomous Pathways

    Zarrouk, M., Rolf, J. & Cantrell, D. A. 22-Mar-2013 In : PLoS ONE. 8, 3, 9 p., e60217

    Research output: Contribution to journal › Article

  6. Sialoadhesin ligand expression identifies a subpopulation of Foxp3- T cells with a distinct activation and glycosylation profile

    Kidder, D., Richards, H. E., Ziltener, H. J., Garden, O. A. & Crocker, P. R. 15-Mar-2013 In : Journal of Immunology. 190, 6, p. 2593-2602, 10 p.

    Research output: Contribution to journal › Article

  7. Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b beta2-integrin-dependent signalling

    McMillan, S. J., Sharma, R. S., McKenzie, E. J., Richards, H. E., Zhang, J., Prescott, A. & Crocker, P. R. 14-Mar-2013 In : Blood. 121, 11, p. 2084-2094, 11 p.

    Research output: Contribution to journal › Article

  8. Hormonal regulation of the Salt-inducible Kinase (SIK), a key mediator that controls hepatic gluconeogenesis

    Patel, K., Goransson, O., Sutherland, C. & Sakamoto, K. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. E2-E2, 1 p., P577

    Research output: Contribution to journal › Meeting abstract

  9. Hormonal regulation of the Salt-inducible Kinase (SIK), a key mediator that controls hepatic gluconeogenesis

    Patel, K., Goransson, O., Sutherland, C. & Sakamoto, K. Mar-2013

    Research output: Contribution to conference › Poster

  10. Insulin sensitising effects of monounsaturated and polyunsaturated fatty acids in skeletal muscle cells

    Nardi, F., Lipina, C., Magill, D. & Hundal, H. S. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. 49-49, 1 p., P70

    Research output: Contribution to journal › Meeting abstract

  11. Obesity-Induced Insulin Resistance in Human Skeletal Muscle Is Characterised by Defective Activation of p42/p44 MAP Kinase

    Ruiz-Alcaraz, A. J., Lipina, C., Petrie, J. R., Murphy, M. J., Morris, A. D., Sutherland, C. & Cuthbertson, D. J. 28-Feb-2013 In : PLoS ONE. 8, 2, e56928

    Research output: Contribution to journal › Article

  12. Metabolism of inflammation limited by AMPK and pseudo-starvation

    O'Neill, L. A. J. & Hardie, D. G. 17-Jan-2013 In : Nature. 493, 7432, p. 346-355, 10 p.

    Research output: Contribution to journal › Article

  13. PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway

    Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15-Jan-2013 In : Journal of Immunology. 190, 2, p. 565-77, 13 p.

    Research output: Contribution to journal › Article

  14. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

    MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S. & Tauro, S. 1-Jan-2013 In : Scientific Reports. 3, 1275

    Research output: Contribution to journal › Article

  15. Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo

    Belch, J. J. F., Akbar, N., Alapati, V., Petrie, J., Arthur, S. & Khan, F. Jan-2013 In : Microvascular Research. 85, p. 86-92, 7 p.

    Research output: Contribution to journal › Article

  16. The role of amino acid transporters in nutrition

    Poncet, N. & Taylor, P. M. Jan-2013 In : Current Opinion in Clinical Nutrition and Metabolic Care. 16, 1, p. 57-65, 9 p.

    Research output: Contribution to journal › Article

  17. Chronic exposure of astrocytes to interferon-alpha reveals molecular changes related to Aicardi-Goutieres syndrome

    Cuadrado, E., Jansen, M. H., Anink, J., De Filippis, L., Vescovi, A. L., Watts, C., Aronica, E., Hol, E. M. & Kuijpers, T. W. 2013 In : Brain. 136, 1, p. 245-258, 14 p.

    Research output: Contribution to journal › Article

  18. Insulin sensitising effects of monounsaturated and polyunsaturated fatty acids in skeletal muscle cells

    Nardi, F., Lipina, C., Magill, D. & Hundal, H. S. 2013

    Research output: Contribution to conference › Poster

  19. MSK1 and 2 inhibit LPS induced prostaglandin production via an IL-10 feedback loop

    Mackenzie, K. F., Van Den Bosch, M. W. M., Naqvi, S., Elcombe, S. E., McGuire, V. A., Reith, A. D., Blackshear, P. J., Dean, J. L. & Arthur, J. S. C. 2013 In : Molecular and Cellular Biology.

    Research output: Contribution to journal › Article

  20. Phospholipase C-eta 2 is required for retinoic acid-stimulated neurite growth

    Popovics, P., Gray, A., Arastoo, M., Finelli, D. K., Tan, A. J. L. & Stewart, A. J. 2013 In : Journal of Neurochemistry. 124, 5, p. 632-644, 13 p.

    Research output: Contribution to journal › Article

  21. The LKB1-AMPK Pathway-Friend or Foe in Cancer?

    Hardie, D. G. 2013 In : Cancer Cell. 23, 2, p. 131-132, 2 p.

    Research output: Contribution to journal › Editorial

  22. The specificity of the interaction between αB-crystallin and desmin filaments and its impact on filament aggregation and cell viability

    Elliott, J. L., Der Perng, M., Prescott, A. R., Jansen, K. A., Koenderink, G. H. & Quinlan, R. A. 2013 In : Philosophical Transactions of the Royal Society B - Biological Sciences. 368, 1617, p. 1-15, 15 p.

    Research output: Contribution to journal › Article

  23. The spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow

    Lek, H. S., Morrison, V. L., Conneely, M., Campbell, P. A., McGloin, D., Kliche, S., Watts, C., Prescott, A. & Fagerholm, S. C. 2013 In : Journal of Biological Chemistry.

    Research output: Contribution to journal › Article

  24. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells

    Finlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L., Rolf, J., Panteleyev, A. A., Okkenhaug, K. & Cantrell, D. A. 17-Dec-2012 In : Journal of Experimental Medicine. 209, 13, p. 2441-2453, 13 p.

    Research output: Contribution to journal › Article

  25. Selective kinase inhibitors as tools for neuroscience research

    Martin, K. J. & Arthur, J. S. C. Dec-2012 In : Neuropharmacology. 63, 7, p. 1227-1237, 11 p.

    Research output: Contribution to journal › Article

  26. Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

    McIver, E. G., Bryans, J., Birchall, K., Chugh, J., Drake, T., Lewis, S. J., Osborne, J., Smiljanic-Hurley, E., Tsang, W., Kamal, A., Levy, A., Newman, M., Taylor, D., Arthur, J. S. C., Clark, K. & Cohen, P. Dec-2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 23, p. 7169-7173, 5 p.

    Research output: Contribution to journal › Article

  27. ZNRF2 is released from membranes by growth factors and with ZNRF1 regulates the Na+/K+ATPase

    Hoxhaj, G., Najafov, A., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 1-Oct-2012 In : Journal of Cell Science. 125, 19, p. 4662-4675

    Research output: Contribution to journal › Article

  28. AKT independent glioma suppression by PTEN

    Zilidis, G., Tibarewal, P., Spinelli, L. & Leslie, N. R. Sep-2012 In : Journal of Neuro-Oncology. 14, p. 8-8, 1 p.

    Research output: Contribution to journal › Meeting abstract

  29. New vistas for treatment of obesity and diabetes?: Endocannabinoid signalling and metabolism in the modulation of energy balance

    Lipina, C., Rastedt, W., Irving, A. J. & Hundal, H. S. 1-Aug-2012 In : BioEssays. 34, 8, p. 681-691, 11 p.

    Research output: Contribution to journal › Article

  30. P38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

    Risco, A., Del Dresno, C., Mambol, A., Alsina-Beauchamp, D., MacKenzie, K. F., Yang, H-T., Barber, D. F., Morcelle, C., Arthur, J. S. C., Ley, S. C., Ardavin, C. F. & Cuenda, A. 10-Jul-2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 28, p. 11200-11205, 6 p.

    Research output: Contribution to journal › Article

  31. IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold

    Dixon, M. J., Gray, A., Schenning, M., Agacan, M., Tempel, W., Tong, Y., Nedyalkova, L., Park, H-W., Leslie, N. R., van Aalten, D. M. F., Downes, C. P. & Batty, I. H. 29-Jun-2012 In : Journal of Biological Chemistry. 287, 27, p. 22483-22496, 14 p.

    Research output: Contribution to journal › Article

  32. The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor signaling

    Dzamko, N., Inesta-Vaquera, F., Zhang, J., Arthur, S., Cohen, P., Clark, K., Alessi, D. R., Xie, C., Cai, H., Tan, L., Choi, H., Gray, N. & Pedrioli, P. 18-Jun-2012 In : PLoS ONE. 7, 6, e39132

    Research output: Contribution to journal › Article

  33. Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells

    Turban, S., Stretton, C., Drouin, O., Green, C. J., Watson, M. L., Gray, A., Ross, F., Lantier, L., Viollet, B., Hardie, D. G., Hundal, H. S. & Marette, A. 8-Jun-2012 In : Journal of Biological Chemistry. 287, 24, p. 20088-20099, 12 p.

    Research output: Contribution to journal › Article

  34. E2F1-dependent methyl cap formation requires RNA pol II phosphorylation

    Aregger, M. & Cowling, V. H. 1-Jun-2012 In : Cell Cycle. 11, 11, p. 2146-2148, 3 p.

    Research output: Contribution to journal › Article

  35. Cellular Responses to the Metal-Binding Properties of Metformin

    Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H-H., Xue, L., Jiang, H., Sakamoto, K., Prescott, A. R. & Rena, G. Jun-2012 In : Diabetes. 61, 6, p. 1423-1433, 11 p.

    Research output: Contribution to journal › Article

  36. Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells

    Magister, Š., Obermajer, N., Mirković, B., Švajger, U., Renko, M., Softić, A., Romih, R., Colbert, J. D., Watts, C. & Kos, J. 1-May-2012 In : European Journal of Cell Biology. 91, 5, p. 391-401, 11 p.

    Research output: Contribution to journal › Article

  37. A pan-endosomal protease inhibitor attenuates endosomal function and improves antigen presentation

    van Kasteren, S., Colbert, J., Berlin, I., Matthews, S., Groettrup, M., Mueller, M., Keane, D. & Watts, C. May-2012 In : Molecular Immunology. 51, 1, p. 34-34, 1 p.

    Research output: Contribution to journal › Special issue

  38. MC1R determines melanocyte viability upon UV irradiation by protecting PTEN activity

    Cao, J., Liu, F., Shen, J., Lenna, S., Jimenez-Cervantes, S., Leslie, N., Xu, G. X., Wang, Y. & Cui, R. May-2012 In : Journal of Investigative Dermatology. 132, p. S126-S126, 1 p.

    Research output: Contribution to journal › Article

  39. Organismal Carbohydrate and Lipid Homeostasis

    Hardie, D. G. May-2012 In : Cold Spring Harbor Perspectives in Biology. 4, 5, p. -, 16 p., a006031

    Research output: Contribution to journal › Article

  40. Protein kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues

    Matthews, S. A., San Lek, H., Morrison, V. L., Mackenzie, M. G., Zarrouk, M., Cantrell, D. & Fagerholm, S. C. May-2012 In : European Journal of Immunology. 42, 5, p. 1316-1326, 11 p.

    Research output: Contribution to journal › Article

  41. AMPK: a nutrient and energy sensor that maintains energy homeostasis

    Hardie, D. G., Ross, F. A. & Hawley, S. A. 1-Apr-2012 In : Nature Reviews Molecular Cell Biology. 13, 4, p. 251-262, 12 p.

    Research output: Contribution to journal › Article

  42. The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a

    Cameron, A. R., Wallace, K., Logie, L., Prescott, A. R., Unterman, T. G., Harthill, J. & Rena, G. 1-Apr-2012 In : Biochemical Journal. 443, p. 57-64, 8 p.

    Research output: Contribution to journal › Article

  43. The role of ATM in response to metformin treatment and activation of AMPK reply

    Zhou, K., Bellenguez, C., Sutherland, C., Hardie, G., Palmer, C., Donnelly, P. & Pearson, E. Apr-2012 In : Nature Genetics. 44, 4, p. 361-362, 2 p.

    Research output: Contribution to journal › Letter

  44. Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

    Navarro, M. N., Sinclair, L. V., Feijoo-Carnero, C., Clarke, R., Matthews, S. A. & Cantrell, D. A. 15-Mar-2012 In : Biochemical Journal. 442, 3, p. 649-659, 11 p.

    Research output: Contribution to journal › Article

  45. Both p110 alpha and p110 beta isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

    Berenjeno, I. M., Guillermet-Guibert, J., Pearce, W., Gray, A., Fleming, S. & Vanhaesebroeck, B. 15-Feb-2012 In : Biochemical Journal. 442, p. 151-159, 9 p.

    Research output: Contribution to journal › Article

  46. Evolution of the vertebrate beaded filament protein, Bfsp2: comparing the in vitro assembly properties of a "tailed" zebrafish Bfsp2 to its "tailless" human orthologue

    Qu, B., Landsbury, A., Schoenthaler, H. B., Dahm, R., Liu, Y., Clark, J. I., Prescott, A. R. & Quinlan, R. A. Jan-2012 In : Experimental Eye Research. 94, 1, p. 192-202, 11 p.

    Research output: Contribution to journal › Article

  47. The endosome-lysosome pathway and information generation in the immune system

    Watts, C. Jan-2012 In : Biochimica et Biophysica Acta. Proteins and Proteomics. 1824, 1, p. 14-21, 8 p.

    Research output: Contribution to journal › Scientific review

  48. A role for PP1/NIPP1 in steering migration of human cancer cells

    Martin-Granados, C., Prescott, A. R., Van Dessel, N., Van Eynde, A., Arocena, M., Klaska, I. P., Görnemann, J., Beullens, M., Bollen, M., Forrester, J. V. & McCaig, C. D. 2012 In : PLoS ONE. 7, 7, e40769

    Research output: Contribution to journal › Article

  49. AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway

    Petti, C., Vegetti, C., Molla, A., Bersani, I., Cleris, L., Mustard, K. J., Formelli, F., Hardie, G. D., Sensi, M. & Anichini, A. 2012 In : Melanoma Research. 22, 5, p. 341-350, 10 p.

    Research output: Contribution to journal › Article

  50. AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells

    Lee, C-W., Wong, L. L-Y., Tse, E. Y-T., Liu, H-F., Leong, V. Y-L., Lee, J. M-F., Hardie, D. G., Ng, I. O-L. & Ching, Y-P. 2012 In : Cancer Research. 72, 17, p. 4394-4404, 11 p.

    Research output: Contribution to journal › Article

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