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Cell Signalling & Immunology

  1. NEU3 sialidase as a marker of insulin sensitivity: Regulation by fatty acids

    Lipina, C., Nardi, F., Grace, H. & Hundal, H. S. 1 Sep 2015 In : Cellular Signalling. 27, 9, p. 1742-1750 9 p.

    Research output: Contribution to journalArticle

  2. Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α

    Rog-Zielinska, E. A., Craig, M. A., Manning, J. R., Richardson, R. V., Gowans, G. J., Dunbar, D. R., Gharbi, K., Kenyon, C. J., Holmes, M. C., Hardie, D. G., Smith, G. L. & Chapman, K. E. 1 Jul 2015 In : Cell Death & Differentiation. 22, 7, p. 1106-1116 11 p.

    Research output: Contribution to journalArticle

  3. AMPK dilates resistance arteries via activation of SERCA and BKCa channels in smooth muscle

    Schneider, H., Schubert, K. M., Blodow, S., Kreutz, C-P., Erdogmus, S., Wiedenmann, M., Qiu, J., Fey, T., Ruth, P., Lubomirov, L. T., Pfitzer, G., Mederos y Schnitzler, M., Hardie, D. G., Gudermann, T. & Pohl, U. Jul 2015 In : Hypertension. 66, 1, p. 108-116 9 p.

    Research output: Contribution to journalArticle

  4. Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance

    Swamy, M., Abeler-Dörner, L., Chettle, J., Mahlakõiv, T., Goubau, D., Chakravarty, P., Ramsay, G., Reis e Sousa, C., Staeheli, P., Blacklaws, B. A., Heeney, J. L. & Hayday, A. C. 19 May 2015 In : Nature Communications. 6, 12 p., 7090

    Research output: Contribution to journalArticle

  5. AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

    Hardie, D. G. Apr 2015 In : Current Opinion in Cell Biology. 33, April, p. 1-7 7 p.

    Research output: Contribution to journalArticle

  6. Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability

    Nardi, F., Hoffmann, T. M., Stretton, C., Cwiklinski, E., Taylor, P. M. & Hundal, H. S. 27 Mar 2015 In : Journal of Biological Chemistry. 290, 13, p. 8173-8184 12 p.

    Research output: Contribution to journalArticle

  7. SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation

    Varshney, D., Vavrova-Anderson, J., Oler, A. J., Cowling, V. H., Cairns, B. R. & White, R. J. 23 Mar 2015 In : Nature Communications. 6, 12 p., 6569

    Research output: Contribution to journalArticle

  8. Identification of caveolar resident proteins in ventricular myocytes using a quantitative proteomic approach: dynamic changes in caveolar composition following adrenoceptor activation

    Wypijewski, K. J., Tinti, M., Chen, W., Lamont, D., Ashford, M. L. J., Calaghan, S. C. & Fuller, W. Mar 2015 In : Molecular & Cellular Proteomics. 14, 3, p. 596-608 13 p.

    Research output: Contribution to journalArticle

  9. ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation

    Stone, E. L., Pepper, M., Katayama, C. D., Kerdiles, Y. M., Lai, C-Y., Emslie, E., Lin, Y. C., Yang, E., Goldrath, A. W., Li, M. O., Cantrell, D. A. & Hedrick, S. M. 17 Feb 2015 In : Immunity. 42, 2, p. 239-251 13 p.

    Research output: Contribution to journalArticle

  10. Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes

    Spinelli, L., Black, F. M., Berg, J. N., Eickholt, B. J. & Leslie, N. R. Feb 2015 In : Journal of Medical Genetics. 52, 2, p. 128-134 7 p.

    Research output: Contribution to journalArticle

  11. Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation

    Pirkmajer, S., Kulkarni, S. S., Tom, R. Z., Ross, F. A., Hawley, S. A., Hardie, D. G., Zierath, J. R. & Chibalin, A. V. Feb 2015 In : Diabetes. 64, 2, p. 360-369 10 p.

    Research output: Contribution to journalArticle

  12. Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis

    Karelina, K., Liu, Y., Alzate-Correa, D., Wheaton, K. L., Hoyt, K. R., Arthur, J. S. C. & Obrietan, K. 29 Jan 2015 In : Neuroscience. 285, p. 292-302 11 p.

    Research output: Contribution to journalArticle

  13. RAB1A promotes Vaccinia virus replication by facilitating the production of intracellular enveloped virions

    Pechenick Jowers, T., Featherstone, R. J., Reynolds, D. K., Brown, H. K., James, J., Prescott, A., Haga, I. R. & Beard, P. M. 15 Jan 2015 In : Virology. 475, p. 66-73 8 p.

    Research output: Contribution to journalArticle

  14. The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases

    Ozanne, J., Prescott, A. R. & Clark, K. 15 Jan 2015 In : Biochemical Journal. 465, 2, p. 271-279 9 p.

    Research output: Contribution to journalArticle

  15. PTEN inhibitors: an evaluation of current compounds

    Spinelli, L., Lindsay, Y. E. & Leslie, N. R. Jan 2015 In : Advances in Biological Regulation. 57, p. 102-111 10 p.

    Research output: Contribution to journalArticle

  16. Environmental and metabolic sensors that control T cell biology

    Ramsay, G. & Cantrell, D. 2015 In : Frontiers in Immunology. 6, 8 p., 99

    Research output: Contribution to journalArticle

  17. High-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow-derived macrophages

    Guo, M., Härtlova, A., Dill, B. D., Prescott, A. R., Gierliński, M. & Trost, M. 2015 In : Proteomics. 12 p.

    Research output: Contribution to journalArticle

  18. The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway

    Bailly, A., Perrin, A., Bou Malhab, L. J., Pion, E., Larance, M., Nagala, M., Smith, P., O'Donohue, M-F., Gleizes, P-E., Zomerdijk, J., Lamond, A. I. & Xirodimas, D. P. 2015 In : Oncogene. 12 p.

    Research output: Contribution to journalArticle

  19. Substrate recognition by the cell surface palmitoyl transferase DHHC5

    Howie, J., Reilly, L., Fraser, N. J., Vlachaki Walker, J., Wypijewski, . K. J., Ashford, M. L. J., Calaghan, S., McClafferty, H., Tian, L., Shipston, M. J., Boguslavskyi, A., Shattock, M. J. & Fuller, W. 9 Dec 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 49, p. 17534-17539 6 p.

    Research output: Contribution to journalArticle

  20. AMPK-sensing energy while talking to other signaling pathways

    Hardie, D. G. 2 Dec 2014 In : Cell Metabolism. 20, 6, p. 939-952 14 p.

    Research output: Contribution to journalArticle

  21. AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

    Hardie, D. G. Dec 2014 In : Journal of Internal Medicine. 276, 6, p. 543-559 17 p.

    Research output: Contribution to journalArticle

  22. Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks

    Navarro, M. N., Goebel, J., Hukelmann, J. L. & Cantrell, D. A. Dec 2014 In : Molecular & Cellular Proteomics. 13, 12, p. 3544-3557 14 p.

    Research output: Contribution to journalArticle

  23. Pseudaminic acid on Campylobacter jejuni flagella modulates dendritic cell IL-10 expression via Siglec-10 receptor: a novel flagellin-host interaction

    Stephenson, H. N., Mills, D. C., Jones, H., Milioris, E., Copland, A., Dorrell, N., Wren, B. W., Crocker, P. R., Escors, D. & Bajaj-Elliott, M. 1 Nov 2014 In : Journal of Infectious Diseases. 210, 9, p. 1487-1498 12 p.

    Research output: Contribution to journalArticle

  24. Carnosic acid stimulates glucose uptake in skeletal muscle cells via a PME-1/PP2A/PKB signalling axis

    Lipina, C. & Hundal, H. S. Nov 2014 In : Cellular Signalling. 26, 11, p. 2343-2349 6 p.

    Research output: Contribution to journalArticle

  25. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

    Bago, R., Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G. & Alessi, D. R. Nov 2014 In : Biochemical Journal. 463, 3, p. 413-427 15 p.

    Research output: Contribution to journalArticle

  26. Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype

    Morrison, V. L., James, M. J., Grzes, K., Cook, P., Glass, D. G., Savinko, T., Lek, H. S., Gawden-Bone, C., Watts, C., Millington, O. R., MacDonald, A. S. & Fagerholm, S. C. 28 Oct 2014 In : Nature Communications. 5, 13 p., 5359

    Research output: Contribution to journalArticle

  27. A crucial role for β2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells

    Gawden-Bone, C., West, M. A., Morrison, V. L., Edgar, A. J., McMillan, S. J., Dill, B. D., Trost, M., Prescott, A., Fagerholm, S. C. & Watts, C. 1 Oct 2014 In : Journal of Cell Science. 127, 19, p. 4213-4224 12 p.

    Research output: Contribution to journalArticle

  28. Siglec-mediated regulation of immune cell function in disease

    Macauley, M. S., Crocker, P. R. & Paulson, J. C. Oct 2014 In : Nature Reviews Immunology. 14, 10, p. 653-666 14 p.

    Research output: Contribution to journalArticle

  29. Valuation of hospital bed-days released by infection control programs: a comparison of methods

    Stewardson, A. J., Harbarth, S., Graves, N. & TIMBER Study Group Oct 2014 In : Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America. 35, 10, p. 1294-1297 4 p.

    Research output: Contribution to journalArticle

  30. Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells

    Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A. 2 Sep 2014 In : PLoS ONE. 9, 9, 7 p., e106710

    Research output: Contribution to journalArticle

  31. Introduction to special issue: 'emerging roles of siglecs in health and disease'

    Crocker, P. R. & Kannagi, R. Sep 2014 In : Glycobiology. 24, 9, p. 784-784 1 p.

    Research output: Contribution to journalArticle

  32. Peripheral prion disease pathogenesis is unaltered in the absence of sialoadhesin (Siglec-1/CD169)

    Bradford, B. M., Crocker, P. R. & Mabbott, N. A. Sep 2014 In : Immunology. 143, 1, p. 120-129 10 p.

    Research output: Contribution to journalArticle

  33. Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus

    Chang, Y-C., Olson, J., Louie, A., Crocker, P. R., Varki, A. & Nizet, V. Sep 2014 In : Journal of Molecular Medicine. 92, 9, p. 951-959 9 p.

    Research output: Contribution to journalArticle

  34. Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung

    McMillan, S. J., Sharma, R. S., Richards, H. E., Hegde, V. & Crocker, P. R. 18 Jul 2014 In : Journal of Biological Chemistry. 289, 29, p. 20370-20376 7 p.

    Research output: Contribution to journalArticle

  35. Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system?

    Lipina, C., Irving, A. J. & Hundal, H. S. 1 Jul 2014 In : American Journal of Physiology, Endocrinology and Metabolism. 307, 1, p. E1-E13

    Research output: Contribution to journalArticle

  36. PDK1 controls upstream PI3K expression and PIP3 generation

    Dieterle, A. M., Böhler, P., Keppeler, H., Alers, S., Berleth, N., Drießen, S., Hieke, N., Pietkiewicz, S., Löffler, A. S., Peter, C., Gray, A., Leslie, N. R., Shinohara, H., Kurosaki, T., Engelke, M., Wienands, J., Bonin, M., Wesselborg, S. & Stork, B. 5 Jun 2014 In : Oncogene. 33, 23, p. 3043-3053 11 p.

    Research output: Contribution to journalArticle

  37. Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies

    Pearce, O. M. T., Läubli, H., Verhagen, A., Secrest, P., Zhang, J., Varki, N. M., Crocker, P. R., Bui, J. D. & Varki, A. 22 Apr 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 16, p. 5998-6003 6 p.

    Research output: Contribution to journalArticle

  38. Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

    Hawley, S. A., Ross, F. A., Gowans, G. J., Tibarewal, P., Leslie, N. R. & Hardie, D. G. 15 Apr 2014 In : Biochemical Journal. 459, 2, p. 275-287 13 p.

    Research output: Contribution to journalArticle

  39. A new protein kinase cascade

    Hardie, D. G. Apr 2014 In : Nature Reviews Molecular Cell Biology. 15, 4, p. 223 1 p.

    Research output: Contribution to journalArticle

  40. Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors

    Liu, R., Iadevaia, V., Averous, J., Taylor, P. M., Zhang, Z. & Proud, C. G. Apr 2014 In : Nucleic Acids Research. 42, 8, p. 5083-5096 14 p.

    Research output: Contribution to journalArticle

  41. A H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation

    Sabbattini, P., Sjoberg, M., Nikic, S., Frangini, A., Holmqvist, P-H., Kunowska, N., Carroll, T., Brookes, E., Arthur, S. J., Pombo, A. & Dillon, N. 15 Mar 2014 In : Molecular Biology of the Cell. 25, 6, p. 904-915 12 p.

    Research output: Contribution to journalArticle

  42. Transcriptionally correlated subcellular dynamics of MBNL1 during lens development and their implication for the molecular pathology of myotonic dystrophy type 1

    Coleman, S. M., Prescott, A. R. & Sleeman, J. E. 1 Mar 2014 In : Biochemical Journal. 458, 2, p. 267-280 14 p.

    Research output: Contribution to journalArticle

  43. AMPK: regulating energy balance at the cellular and whole body levels

    Hardie, D. G. & Ashford, M. L. J. Mar 2014 In : Physiology. 29, 2, p. 99-107 9 p.

    Research output: Contribution to journalArticle

  44. Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A

    Nardi, F., Lipina, C., Magill, D., Hage Hassan, R., Hajduch, E., Gray, A. & Hundal, H. S. Mar 2014 In : PLoS ONE. 9, 3, 10 p., e92255

    Research output: Contribution to journalArticle

  45. The catalytic subunit of the system L1 amino acid transporter (Slc7a5) facilitates nutrient signalling in mouse skeletal muscle

    Poncet, N., Mitchell, F. E., Ibrahim, A. F. M., McGuire, V. A., English, G., Arthur, J. S. C., Shi, Y-B. & Taylor, P. M. 26 Feb 2014 In : PLoS ONE. 9, 2, 14 p., e89547

    Research output: Contribution to journalArticle

  46. Time-resolved quantitative proteomics implicates the core snRNP protein SmB together with SMN in neural trafficking

    Prescott, A. R., Bales, A., James, J., Trinkle-Mulcahy, L. & Sleeman, J. E. 15 Feb 2014 In : Journal of Cell Science. 127, 4, p. 812-827 16 p.

    Research output: Contribution to journalArticle

  47. AMPK: a cellular energy sensor primarily regulated by AMP

    Gowans, G. J. & Hardie, D. G. 1 Feb 2014 In : Biochemical Society Transactions. 42, 1, p. 71-75 5 p.

    Research output: Contribution to journalArticle

  48. RAM function is dependent on Kapβ2-mediated nuclear entry

    Gonatopoulos-Pournatzis, T. & Cowling, V. H. 1 Feb 2014 In : Biochemical Journal. 457, 3, p. 473-484 12 p.

    Research output: Contribution to journalArticle

  49. Cap-binding complex (CBC)

    Gonatopoulos-Pournatzis, T. & Cowling, V. H. 15 Jan 2014 In : Biochemical Journal. 457, 2, p. 231-242 12 p.

    Research output: Contribution to journalScientific review

  50. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

    Banerjee, S., Buhrlage, S. J., Huang, H-T., Deng, X., Zhou, W., Wang, J., Traynor, R., Prescott, A. R., Alessi, D. R. & Gray, N. S. 1 Jan 2014 In : Biochemical Journal. 457, 1, p. 215-225 11 p.

    Research output: Contribution to journalArticle

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