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  1. IFNβ autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages

    Pattison, M. J., MacKenzie, K. F., Elcombe, S. E. & Arthur, J. S. C. 21-May-2013 In : FEBS Letters. 587, 10, p. 1496-1503, 8 p.

    Research output: Contribution to journal › Article

  2. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

    Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y-B., Taylor, P. M. & Cantrell, D. A. May-2013 In : Nature Immunology. 14, 5, p. 500-508, 9 p.

    Research output: Contribution to journal › Article

  3. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

    Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3-Apr-2013 In : EMBO Journal. 32, 7, p. 1008-22, 15 p.

    Research output: Contribution to journal › Article

  4. AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

    Dandapani, M. & Hardie, D. G. Apr-2013 In : Biochemical Society Transactions. 41, 2, p. 687-693, 7 p.

    Research output: Contribution to journal › Article

  5. Dectin-1 Regulates IL-10 Production via a MSK1/2 and CREB Dependent Pathway and Promotes the Induction of Regulatory Macrophage Markers

    Elcombe, S. E., Naqvi, S., Van den Bosch, M. W. M., MacKenzie, K. F., Cianfanelli, F., Brown, G. D. & Arthur, J. S. C. 22-Mar-2013 In : PLoS ONE. 8, 3, 15 p., e60086

    Research output: Contribution to journal › Article

  6. LKB1 Mediates the Development of Conventional and Innate T Cells via AMP-Dependent Kinase Autonomous Pathways

    Zarrouk, M., Rolf, J. & Cantrell, D. A. 22-Mar-2013 In : PLoS ONE. 8, 3, 9 p., e60217

    Research output: Contribution to journal › Article

  7. Sialoadhesin ligand expression identifies a subpopulation of Foxp3- T cells with a distinct activation and glycosylation profile

    Kidder, D., Richards, H. E., Ziltener, H. J., Garden, O. A. & Crocker, P. R. 15-Mar-2013 In : Journal of Immunology. 190, 6, p. 2593-2602, 10 p.

    Research output: Contribution to journal › Article

  8. Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b beta2-integrin-dependent signalling

    McMillan, S. J., Sharma, R. S., McKenzie, E. J., Richards, H. E., Zhang, J., Prescott, A. & Crocker, P. R. 14-Mar-2013 In : Blood. 121, 11, p. 2084-2094, 11 p.

    Research output: Contribution to journal › Article

  9. Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors

    Horan, K. A., Hansen, K., Jakobsen, M. R., Holm, C. K., Søby, S., Unterholzner, L., Thompson, M., West, J. A., Iversen, M. B., Rasmussen, S. B., Ellermann-Eriksen, S., Kurt-Jones, E., Landolfo, S., Damania, B., Melchjorsen, J., Bowie, A. G., Fitzgerald, K. A. & Paludan, S. R. 1-Mar-2013 In : Journal of Immunology. 190, 5, p. 2311-2319, 9 p.

    Research output: Contribution to journal › Article

  10. Hormonal regulation of the Salt-inducible Kinase (SIK), a key mediator that controls hepatic gluconeogenesis

    Patel, K., Goransson, O., Sutherland, C. & Sakamoto, K. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. E2-E2, 1 p., P577

    Research output: Contribution to journal › Meeting abstract

  11. Hormonal regulation of the Salt-inducible Kinase (SIK), a key mediator that controls hepatic gluconeogenesis

    Patel, K., Goransson, O., Sutherland, C. & Sakamoto, K. Mar-2013

    Research output: Contribution to conference › Poster

  12. Insulin sensitising effects of monounsaturated and polyunsaturated fatty acids in skeletal muscle cells

    Nardi, F., Lipina, C., Magill, D. & Hundal, H. S. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. 49-49, 1 p., P70

    Research output: Contribution to journal › Meeting abstract

  13. Obesity-Induced Insulin Resistance in Human Skeletal Muscle Is Characterised by Defective Activation of p42/p44 MAP Kinase

    Ruiz-Alcaraz, A. J., Lipina, C., Petrie, J. R., Murphy, M. J., Morris, A. D., Sutherland, C. & Cuthbertson, D. J. 28-Feb-2013 In : PLoS ONE. 8, 2, e56928

    Research output: Contribution to journal › Article

  14. Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence

    Mansur, D. S., Maluquer de Motes, C., Unterholzner, L., Sumner, R. P., Ferguson, B. J., Ren, H., Strnadova, P., Bowie, A. G. & Smith, G. L. 28-Feb-2013 In : PLoS Pathogens. 9, 2, e1003183

    Research output: Contribution to journal › Article

  15. Metabolism of inflammation limited by AMPK and pseudo-starvation

    O'Neill, L. A. J. & Hardie, D. G. 17-Jan-2013 In : Nature. 493, 7432, p. 346-355, 10 p.

    Research output: Contribution to journal › Article

  16. PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway

    Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15-Jan-2013 In : Journal of Immunology. 190, 2, p. 565-77, 13 p.

    Research output: Contribution to journal › Article

  17. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

    MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S. & Tauro, S. 1-Jan-2013 In : Scientific Reports. 3, 1275

    Research output: Contribution to journal › Article

  18. Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo

    Belch, J. J. F., Akbar, N., Alapati, V., Petrie, J., Arthur, S. & Khan, F. Jan-2013 In : Microvascular Research. 85, p. 86-92, 7 p.

    Research output: Contribution to journal › Article

  19. The role of amino acid transporters in nutrition

    Poncet, N. & Taylor, P. M. Jan-2013 In : Current Opinion in Clinical Nutrition and Metabolic Care. 16, 1, p. 57-65, 9 p.

    Research output: Contribution to journal › Article

  20. Chronic exposure of astrocytes to interferon-alpha reveals molecular changes related to Aicardi-Goutieres syndrome

    Cuadrado, E., Jansen, M. H., Anink, J., De Filippis, L., Vescovi, A. L., Watts, C., Aronica, E., Hol, E. M. & Kuijpers, T. W. 2013 In : Brain. 136, 1, p. 245-258, 14 p.

    Research output: Contribution to journal › Article

  21. Insulin sensitising effects of monounsaturated and polyunsaturated fatty acids in skeletal muscle cells

    Nardi, F., Lipina, C., Magill, D. & Hundal, H. S. 2013

    Research output: Contribution to conference › Poster

  22. MSK1 and 2 inhibit LPS induced prostaglandin production via an IL-10 feedback loop

    Mackenzie, K. F., Van Den Bosch, M. W. M., Naqvi, S., Elcombe, S. E., McGuire, V. A., Reith, A. D., Blackshear, P. J., Dean, J. L. & Arthur, J. S. C. 2013 In : Molecular and Cellular Biology.

    Research output: Contribution to journal › Article

  23. Phospholipase C-eta 2 is required for retinoic acid-stimulated neurite growth

    Popovics, P., Gray, A., Arastoo, M., Finelli, D. K., Tan, A. J. L. & Stewart, A. J. 2013 In : Journal of Neurochemistry. 124, 5, p. 632-644, 13 p.

    Research output: Contribution to journal › Article

  24. The LKB1-AMPK Pathway-Friend or Foe in Cancer?

    Hardie, D. G. 2013 In : Cancer Cell. 23, 2, p. 131-132, 2 p.

    Research output: Contribution to journal › Editorial

  25. The specificity of the interaction between αB-crystallin and desmin filaments and its impact on filament aggregation and cell viability

    Elliott, J. L., Der Perng, M., Prescott, A. R., Jansen, K. A., Koenderink, G. H. & Quinlan, R. A. 2013 In : Philosophical Transactions of the Royal Society B - Biological Sciences. 368, 1617, p. 1-15, 15 p.

    Research output: Contribution to journal › Article

  26. The spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow

    Lek, H. S., Morrison, V. L., Conneely, M., Campbell, P. A., McGloin, D., Kliche, S., Watts, C., Prescott, A. & Fagerholm, S. C. 2013 In : Journal of Biological Chemistry.

    Research output: Contribution to journal › Article

  27. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells

    Finlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L., Rolf, J., Panteleyev, A. A., Okkenhaug, K. & Cantrell, D. A. 17-Dec-2012 In : Journal of Experimental Medicine. 209, 13, p. 2441-2453, 13 p.

    Research output: Contribution to journal › Article

  28. Selective kinase inhibitors as tools for neuroscience research

    Martin, K. J. & Arthur, J. S. C. Dec-2012 In : Neuropharmacology. 63, 7, p. 1227-1237, 11 p.

    Research output: Contribution to journal › Article

  29. Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

    McIver, E. G., Bryans, J., Birchall, K., Chugh, J., Drake, T., Lewis, S. J., Osborne, J., Smiljanic-Hurley, E., Tsang, W., Kamal, A., Levy, A., Newman, M., Taylor, D., Arthur, J. S. C., Clark, K. & Cohen, P. Dec-2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 23, p. 7169-7173, 5 p.

    Research output: Contribution to journal › Article

  30. ZNRF2 is released from membranes by growth factors and with ZNRF1 regulates the Na+/K+ATPase

    Hoxhaj, G., Najafov, A., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 1-Oct-2012 In : Journal of Cell Science. 125, 19, p. 4662-4675

    Research output: Contribution to journal › Article

  31. AKT independent glioma suppression by PTEN

    Zilidis, G., Tibarewal, P., Spinelli, L. & Leslie, N. R. Sep-2012 In : Journal of Neuro-Oncology. 14, p. 8-8, 1 p.

    Research output: Contribution to journal › Meeting abstract

  32. System L amino acid transporter 1 (slc7a5) expression is crucial for T cell blastogenesis

    Sinclair, L. V., Taylor, P. M. & Cantrell, D. A. Sep-2012 In : Immunology. 137, s1, p. 347-347, 1 p.

    Research output: Contribution to journal › Meeting abstract

  33. New vistas for treatment of obesity and diabetes?: Endocannabinoid signalling and metabolism in the modulation of energy balance

    Lipina, C., Rastedt, W., Irving, A. J. & Hundal, H. S. 1-Aug-2012 In : BioEssays. 34, 8, p. 681-691, 11 p.

    Research output: Contribution to journal › Article

  34. P38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

    Risco, A., Del Dresno, C., Mambol, A., Alsina-Beauchamp, D., MacKenzie, K. F., Yang, H-T., Barber, D. F., Morcelle, C., Arthur, J. S. C., Ley, S. C., Ardavin, C. F. & Cuenda, A. 10-Jul-2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 28, p. 11200-11205, 6 p.

    Research output: Contribution to journal › Article

  35. IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold

    Dixon, M. J., Gray, A., Schenning, M., Agacan, M., Tempel, W., Tong, Y., Nedyalkova, L., Park, H-W., Leslie, N. R., van Aalten, D. M. F., Downes, C. P. & Batty, I. H. 29-Jun-2012 In : Journal of Biological Chemistry. 287, 27, p. 22483-22496, 14 p.

    Research output: Contribution to journal › Article

  36. The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor signaling

    Dzamko, N., Inesta-Vaquera, F., Zhang, J., Arthur, S., Cohen, P., Clark, K., Alessi, D. R., Xie, C., Cai, H., Tan, L., Choi, H., Gray, N. & Pedrioli, P. 18-Jun-2012 In : PLoS ONE. 7, 6, e39132

    Research output: Contribution to journal › Article

  37. Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells

    Turban, S., Stretton, C., Drouin, O., Green, C. J., Watson, M. L., Gray, A., Ross, F., Lantier, L., Viollet, B., Hardie, D. G., Hundal, H. S. & Marette, A. 8-Jun-2012 In : Journal of Biological Chemistry. 287, 24, p. 20088-20099, 12 p.

    Research output: Contribution to journal › Article

  38. E2F1-dependent methyl cap formation requires RNA pol II phosphorylation

    Aregger, M. & Cowling, V. H. 1-Jun-2012 In : Cell Cycle. 11, 11, p. 2146-2148, 3 p.

    Research output: Contribution to journal › Article

  39. Cellular Responses to the Metal-Binding Properties of Metformin

    Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H-H., Xue, L., Jiang, H., Sakamoto, K., Prescott, A. R. & Rena, G. Jun-2012 In : Diabetes. 61, 6, p. 1423-1433, 11 p.

    Research output: Contribution to journal › Article

  40. Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells

    Magister, Š., Obermajer, N., Mirković, B., Švajger, U., Renko, M., Softić, A., Romih, R., Colbert, J. D., Watts, C. & Kos, J. 1-May-2012 In : European Journal of Cell Biology. 91, 5, p. 391-401, 11 p.

    Research output: Contribution to journal › Article

  41. A pan-endosomal protease inhibitor attenuates endosomal function and improves antigen presentation

    van Kasteren, S., Colbert, J., Berlin, I., Matthews, S., Groettrup, M., Mueller, M., Keane, D. & Watts, C. May-2012 In : Molecular Immunology. 51, 1, p. 34-34, 1 p.

    Research output: Contribution to journal › Special issue

  42. MC1R determines melanocyte viability upon UV irradiation by protecting PTEN activity

    Cao, J., Liu, F., Shen, J., Lenna, S., Jimenez-Cervantes, S., Leslie, N., Xu, G. X., Wang, Y. & Cui, R. May-2012 In : Journal of Investigative Dermatology. 132, p. S126-S126, 1 p.

    Research output: Contribution to journal › Article

  43. Organismal Carbohydrate and Lipid Homeostasis

    Hardie, D. G. May-2012 In : Cold Spring Harbor Perspectives in Biology. 4, 5, p. -, 16 p., a006031

    Research output: Contribution to journal › Article

  44. Protein kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues

    Matthews, S. A., San Lek, H., Morrison, V. L., Mackenzie, M. G., Zarrouk, M., Cantrell, D. & Fagerholm, S. C. May-2012 In : European Journal of Immunology. 42, 5, p. 1316-1326, 11 p.

    Research output: Contribution to journal › Article

  45. Structures of the HIN domain: DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor

    Jin, T., Perry, A., Jiang, J., Smith, P., Curry, J. A., Unterholzner, L., Jiang, Z., Horvath, G., Rathinam, V. A., Johnstone, R. W., Hornung, V., Latz, E., Bowie, A. G., Fitzgerald, K. A. & Xiao, T. S. 20-Apr-2012 In : Immunity. 36, 4, p. 561-571, 11 p.

    Research output: Contribution to journal › Article

  46. AMPK: a nutrient and energy sensor that maintains energy homeostasis

    Hardie, D. G., Ross, F. A. & Hawley, S. A. 1-Apr-2012 In : Nature Reviews Molecular Cell Biology. 13, 4, p. 251-262, 12 p.

    Research output: Contribution to journal › Article

  47. The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a

    Cameron, A. R., Wallace, K., Logie, L., Prescott, A. R., Unterman, T. G., Harthill, J. & Rena, G. 1-Apr-2012 In : Biochemical Journal. 443, p. 57-64, 8 p.

    Research output: Contribution to journal › Article

  48. The role of ATM in response to metformin treatment and activation of AMPK reply

    Zhou, K., Bellenguez, C., Sutherland, C., Hardie, G., Palmer, C., Donnelly, P. & Pearson, E. Apr-2012 In : Nature Genetics. 44, 4, p. 361-362, 2 p.

    Research output: Contribution to journal › Letter

  49. Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

    Navarro, M. N., Sinclair, L. V., Feijoo-Carnero, C., Clarke, R., Matthews, S. A. & Cantrell, D. A. 15-Mar-2012 In : Biochemical Journal. 442, 3, p. 649-659, 11 p.

    Research output: Contribution to journal › Article

  50. Both p110 alpha and p110 beta isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

    Berenjeno, I. M., Guillermet-Guibert, J., Pearce, W., Gray, A., Fleming, S. & Vanhaesebroeck, B. 15-Feb-2012 In : Biochemical Journal. 442, p. 151-159, 9 p.

    Research output: Contribution to journal › Article

  51. Evolution of the vertebrate beaded filament protein, Bfsp2: comparing the in vitro assembly properties of a "tailed" zebrafish Bfsp2 to its "tailless" human orthologue

    Qu, B., Landsbury, A., Schoenthaler, H. B., Dahm, R., Liu, Y., Clark, J. I., Prescott, A. R. & Quinlan, R. A. Jan-2012 In : Experimental Eye Research. 94, 1, p. 192-202, 11 p.

    Research output: Contribution to journal › Article

  52. The endosome-lysosome pathway and information generation in the immune system

    Watts, C. Jan-2012 In : Biochimica et Biophysica Acta. Proteins and Proteomics. 1824, 1, p. 14-21, 8 p.

    Research output: Contribution to journal › Scientific review

  53. A role for PP1/NIPP1 in steering migration of human cancer cells

    Martin-Granados, C., Prescott, A. R., Van Dessel, N., Van Eynde, A., Arocena, M., Klaska, I. P., Görnemann, J., Beullens, M., Bollen, M., Forrester, J. V. & McCaig, C. D. 2012 In : PLoS ONE. 7, 7, e40769

    Research output: Contribution to journal › Article

  54. AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway

    Petti, C., Vegetti, C., Molla, A., Bersani, I., Cleris, L., Mustard, K. J., Formelli, F., Hardie, G. D., Sensi, M. & Anichini, A. 2012 In : Melanoma Research. 22, 5, p. 341-350, 10 p.

    Research output: Contribution to journal › Article

  55. AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells

    Lee, C-W., Wong, L. L-Y., Tse, E. Y-T., Liu, H-F., Leong, V. Y-L., Lee, J. M-F., Hardie, D. G., Ng, I. O-L. & Ching, Y-P. 2012 In : Cancer Research. 72, 17, p. 4394-4404, 11 p.

    Research output: Contribution to journal › Article

  56. Application of a novel highly sensitive activity-based probe for detection of cathepsin G

    Zou, F., Schmon, M., Sienczyk, M., Grzywa, R., Palesch, D., Boehm, B. O., Sun, Z. L., Watts, C., Schirmbeck, R. & Burster, T. 2012 In : Analytical Biochemistry. 421, 2, p. 667-72, 6 p.

    Research output: Contribution to journal › Article

  57. CD33-related siglecs as potential modulators of inflammatory responses

    Crocker, P. R., McMillan, S. J. & Richards, H. E. 2012 In : Annals of the New York Academy of Sciences. 1253, p. 102-111, 10 p.

    Research output: Contribution to journal › Article

  58. Disordered insulin secretion in the development of insulin resistance and Type 2 diabetes

    Schofield, C. J. & Sutherland, C. 2012 In : Diabetic Medicine. 29, 8, p. 972-979, 8 p.

    Research output: Contribution to journal › Book/Film/Article review

  59. Expression and function of thyroid hormone transporters in the microvillous plasma membrane of human term placental syncytiotrophoblast

    Loubière, L. S., Vasilopoulou, E., Glazier, J. D., Taylor, P. M., Franklyn, J. A., Kilby, M. D. & Chan, S. Y. 2012 In : Endocrinology. 153, 12, p. 6126-6135, 10 p.

    Research output: Contribution to journal › Article

  60. Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback

    Pattison, M. J., MacKenzie, K. F. & Arthur, J. S. C. 2012 In : Journal of Immunology. 189, 6, p. 2784-2792, 9 p.

    Research output: Contribution to journal › Article

  61. Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus

    Choi, Y-S., Karelina, K., Alzate-Correa, D., Hoyt, K. R., Impey, S., Arthur, J. S. & Obrietan, K. 2012 In : Journal of Neurochemistry. 123, 5, p. 676-688, 13 p.

    Research output: Contribution to journal › Article

  62. MSK1 regulates homeostatic and experience-dependent synaptic plasticity

    Corrêa, S. A. L., Hunter, C. J., Palygin, O., Wauters, S. C., Martin, K. J., McKenzie, C., McKelvey, K., Morris, R. G. M., Pankratov, Y., Arthur, J. S. C. & Frenguelli, B. 2012 In : Journal of Neuroscience. 32, 38, p. 13039-13051, 13 p.

    Research output: Contribution to journal › Article

  63. Novel methods for the quantification of changes in actin organization in chondrocytes using fluorescent imaging and linear profiling

    Qusous, A., Parker, E., Geewan, C., Kapasi, A., Getting, S. J., Hucklebridge, F., Keshavarz, T. & Kerrigan, M. J. P. 2012 In : Microscopy Research and Technique. 75, 7, p. 991-999, 9 p.

    Research output: Contribution to journal › Article

  64. Pellino1 Is Required for Interferon Production by Viral Double-stranded RNA

    Enesa, K., Ordureau, A., Smith, H., Barford, D., Cheung, P. C. F., Patterson-Kane, J., Arthur, J. S. C. & Cohen, P. 2012 In : Journal of Biological Chemistry. 287, 41, p. 34825-34835, 11 p.

    Research output: Contribution to journal › Article

  65. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

    Clark, K., Mackenzie, K. F., Petkevicius, K., Kristariyanto, Y., Zhang, J., Choi, H. G., Peggie, M., Plater, L., Pedrioli, P. G. A., McIver, E., Gray, N. S., Arthur, J. S. C. & Cohen, P. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 42, p. 16986-91, 6 p.

    Research output: Contribution to journal › Article

  66. PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

    Tibarewal, P., Zilidis, G., Spinelli, L., Schurch, N., Maccario, H., Gray, A., Perera, N. M., Davidson, L., Barton, G. J. & Leslie, N. R. 2012 In : Science Signaling. 5, 213, p. ra18

    Research output: Contribution to journal › Article

  67. The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser in adipocytes

    Henriksson, E., Jones, H. A., Patel, K., Peggie, M., Morrice, N., Sakamoto, K. & Göransson, O. 2012 In : Biochemical Journal. 444, 3, p. 503-514, 12 p.

    Research output: Contribution to journal › Article

  68. The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

    Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., Kemp, B. E., Sakamoto, K., Steinberg, G. R. & Hardie, D. G. 2012 In : Science.

    Research output: Contribution to journal › Article

  69. The Phenotypic Characterization of A13/BACii, a Novel Bovine Chondrocytic Cell Line with Differentiation Potential

    Qusous, A., Kaneva, M., Can, V. C., Getting, S. J. & Kerrigan, M. J. P. 2012 In : Cells tissues organs. 196, 3, p. 251-261, 11 p.

    Research output: Contribution to journal › Article

  70. Internalization of Exogenous Cystatin F Supresses Cysteine Proteases and Induces the Accumulation of Single-chain Cathepsin L by Multiple Mechanisms

    Colbert, J. D., Matthews, S. P., Kos, J. & Watts, C. 9-Dec-2011 In : Journal of Biological Chemistry. 286, 49, p. 42082-42090, 9 p.

    Research output: Contribution to journal › Article

  71. RAM/Fam103a1 is required for mRNA cap methylation

    Gonatopoulos-Pournatzis, T., Dunn, S., Bounds, R. & Cowling, V. H. 18-Nov-2011 In : Molecular Cell. 44, 4, p. 585-596, 12 p.

    Research output: Contribution to journal › Article

  72. Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability

    Ikematsu, N., Dallas, M. L., Ross, F. A., Lewis, R. W., Rafferty, J. N., David, J. A., Suman, R., Peers, C., Hardie, D. G. & Evans, A. M. 1-Nov-2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 44, p. 18132-18137, 6 p.

    Research output: Contribution to journal › Article

  73. A Multifunctional Protease Inhibitor To Regulate Endolysosomal Function

    van Kasteren, S. I., Berlin, I., Colbert, J. D., Keane, D., Ovaa, H. & Watts, C. Nov-2011 In : ACS Chemical Biology. 6, 11, p. 1198-1204, 7 p.

    Research output: Contribution to journal › Article

  74. Erratum to Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance (vol 54, pg 1596, 2011).

    Lipina, C. & Hundal, H. S. Nov-2011 In : Diabetologia. 54, 11, p. 2969-2969, 1 p.

    Research output: Contribution to journal › Article

  75. Evidence for Direct Cross-Talk between Two Essential Nutrient-Sensing Enzymes: O-GlcNAc Transferase (OGT) and AMP-activated Kinase (AMPK)

    Bullen, J., Balsbaugh, J., Neumann, D., Hardie, G., Shabanowitz, J., Hunt, D. & Hart, G. Nov-2011 In : Glycobiology. 21, 11, p. 1487-1487, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  76. Recognition of immunogold markers in electron micrographs

    Wang, R., Pokhariya, H., McKenna, S. J. & Lucocq, J. Nov-2011 In : Journal of Structural Biology. 176, 2, p. 151-158, 8 p.

    Research output: Contribution to journal › Article

  77. Early murine T-lymphocyte activation is accompanied by a switch from N-glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E

    Redelinghuys, P., Antonopoulos, A., Liu, Y., Campanero-Rhodes, M. A., McKenzie, E., Haslam, S. M., Dell, A., Feizi, T. & Crocker, P. R. 7-Oct-2011 In : Journal of Biological Chemistry. 286, 40, p. 34522-34532, 11 p.

    Research output: Contribution to journal › Article

  78. Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells

    Watson, M. L., Macrae, K., Marley, A. E. & Hundal, H. S. 5-Oct-2011 In : PLoS ONE. 6, 10, p. -, 12 p., e25975

    Research output: Contribution to journal › Article

  79. An intranucleolar body associated with rDNA

    Hutten, S., Prescott, A., James, J., Riesenberg, S., Boulon, S., Lam, Y. W. & Lamond, A. I. Oct-2011 In : Chromosoma. 120, 5, p. 481-499, 19 p.

    Research output: Contribution to journal › Article

  80. AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

    Hardie, D. G. 15-Sep-2011 In : Genes & Development. 25, 18, p. 1895-1908, 14 p.

    Research output: Contribution to journal › Scientific review

  81. Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7

    Unterholzner, L., Sumner, R. P., Baran, M., Ren, H., Mansur, D. S., Bourke, N. M., Randow, F., Smith, G. L. & Bowie, A. G. 8-Sep-2011 In : PLoS Pathogens. 7, 9, e1002247

    Research output: Contribution to journal › Article

  82. AMP-activated protein kinase: also regulated by ADP?

    Hardie, D. G., Carling, D. & Gamblin, S. J. Sep-2011 In : Trends in Biochemical Sciences. 36, 9, p. 470-477, 8 p.

    Research output: Contribution to journal › Scientific review

  83. Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet

    Jamieson, P. M., Cleasby, M. E., Kuperman, Y., Morton, N. M., Kelly, P. A. T., Brownstein, D. G., Mustard, K. J., Vaughan, J. M., Carter, R. N., Hahn, C. N., Hardie, D. G., Seckl, J. R., Chen, A. & Vale, W. W. Sep-2011 In : Diabetologia. 54, 9, p. 2392-2403, 12 p.

    Research output: Contribution to journal › Article

  84. YuaB Functions Synergistically with the Exopolysaccharide and TasA Amyloid Fibers To Allow Biofilm Formation by Bacillus subtilis

    Ostrowski, A., Mehert, A., Prescott, A., Kiley, T. B. & Stanley-Wall, N. R. Sep-2011 In : Journal of Bacteriology. 193, 18, p. 4821-4831, 11 p.

    Research output: Contribution to journal › Article

  85. Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial

    Hadad, S., Iwamoto, T., Jordan, L., Purdie, C., Bray, S., Baker, L., Jellema, G., Deharo, S., Hardie, D. G., Pusztai, L., Moulder-Thompson, S., Dewar, J. A. & Thompson, A. M. Aug-2011 In : Breast Cancer Research and Treatment. 128, 3, p. 783-794, 12 p.

    Research output: Contribution to journal › Article

  86. Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2

    Konopatskaya, O., Matthews, S. A., Harper, M. T., Gilio, K., Cosemans, J. M. E. M., Williams, C. M., Navarro, M. N., Carter, D. A., Heemskerk, J. W. M., Leitges, M., Cantrell, D. & Poole, A. W. 14-Jul-2011 In : Blood. 118, 2, p. 416-424, 9 p.

    Research output: Contribution to journal › Article

  87. TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

    Bouskila, M., Esoof, N., Gay, L., Fang, E. H., Deak, M., Begley, M. J., Cantley, L. C., Prescott, A., Storey, K. G. & Alessi, D. R. 1-Jul-2011 In : Biochemical Journal. 437, p. 157-167, 11 p.

    Research output: Contribution to journal › Article

  88. Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance

    Lipina, C. & Hundal, H. S. Jul-2011 In : Diabetologia. 54, 7, p. 1596-1607, 12 p.

    Research output: Contribution to journal › Scientific review

  89. SNAT2 transceptor signalling via mTOR: a role in cell growth and proliferation?

    Pinilla, J., Aledo, J. C., Cwiklinski, E., Hyde, R., Taylor, P. M. & Hundal, H. S. 1-Jun-2011 In : Frontiers in Bioscience (Elite Edition). E3, 4, p. 1289-1299, 11 p.

    Research output: Contribution to journal › Article

  90. AMP-activated protein kinase, a tumor suppressor that opposes the metabolic changes in cancer cells

    Hardie, D. G. Jun-2011 In : FEBS Journal. 278, s1, p. 41-42, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  91. Innate DNA sensing moves to the nucleus

    Unterholzner, L. & Bowie, A. G. 19-May-2011 9, 5, p. 351-353, 3 p.

    Research output: Contribution to journal › Article

  92. A Systemic Lupus Erythematosus-associated R77H Substitution in the CD11b Chain of the Mac-1 Integrin Compromises Leukocyte Adhesion and Phagocytosis

    MacPherson, M., Lek, H. S., Prescott, A. & Fagerholm, S. C. 13-May-2011 In : Journal of Biological Chemistry. 286, 19, p. 17303-17310, 8 p.

    Research output: Contribution to journal › Article

  93. Proteomic tools for the analysis of transient interactions between metalloproteins

    Martínez-Fábregas, J., Rubio, S., Díaz-Quintana, A., Díaz-Moreno, I. & De La Rosa, M. A. 1-May-2011 In : FEBS Journal. 278, 9, p. 1401-1410, 10 p.

    Research output: Contribution to journal › Article

  94. Asparagine endopeptidase is required for normal kidney physiology and homeostasis

    Miller, G., Matthews, S. P., Reinheckel, T., Fleming, S. & Watts, C. May-2011 In : FASEB Journal. 25, 5, p. 1606-1617, 12 p.

    Research output: Contribution to journal › Article

  95. Homeostasis in the vertebrate lens: mechanisms of solute exchange

    Dahm, R., van Marle, J., Quinlan, R. A., Prescott, A. R. & Vrensen, G. F. J. M. 27-Apr-2011 In : Philosophical Transactions of the Royal Society B - Biological Sciences. 366, 1568, p. 1265-1277, 13 p.

    Research output: Contribution to journal › Scientific review

  96. Intracellular ATP Influences Synaptic Plasticity in Area CA1 of Rat Hippocampus via Metabolism to Adenosine and Activity-Dependent Activation of Adenosine A(1) Receptors

    zur Nedden, S., Hawley, S., Pentland, N., Hardie, D. G., Doney, A. S. & Frenguelli, B. 20-Apr-2011 In : Journal of Neuroscience. 31, 16, p. 6221-6234, 14 p.

    Research output: Contribution to journal › Article

  97. Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor kappa B signalling in rat skeletal muscle cells by AMP-activated protein kinase

    Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, K. & Hundal, H. S. 15-Apr-2011 In : Biochemical Journal. 435, p. 463-474, 12 p.

    Research output: Contribution to journal › Article

  98. Signal transduction: how cells sense energy

    Hardie, D. G. 14-Apr-2011 In : Nature. 472, 7342, p. 176-177, 2 p.

    Research output: Contribution to journal › Editorial

  99. Selective Expression in Carotid Body Type I Cells of a Single Splice Variant of the Large Conductance Calcium- and Voltage-activated Potassium Channel Confers Regulation by AMP-activated Protein Kinase

    Ross, F. A., Rafferty, J. N., Dallas, M. L., Ogunbayo, O., Ikematsu, N., McClafferty, H., Tian, L., Widmer, H., Rowe, I. C. M., Wyatt, C. N., Shipston, M. J., Peers, C., Hardie, D. G. & Evans, A. M. 8-Apr-2011 In : Journal of Biological Chemistry. 286, 14, p. 11929-11936, 8 p.

    Research output: Contribution to journal › Article

  100. A Screen for Novel Phosphoinositide 3-kinase Effector Proteins

    Dixon, M. J., Gray, A., Boisvert, F-M., Agacan, M., Morrice, N. A., Gourlay, R., Leslie, N. R., Downes, C. P. & Batty, I. H. Apr-2011 In : Molecular & Cellular Proteomics. 10, 4, p. -, 13 p., 003178

    Research output: Contribution to journal › Article

  101. Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

    Deng, X., Dzamko, N., Prescott, A., Davies, P., Liu, Q., Yang, Q., Lee, J-D., Patricelli, M. P., Nomanbhoy, T. K., Alessi, D. R. & Gray, N. S. Apr-2011 In : Nature Chemical Biology. 7, 4, p. 203-205, 3 p.

    Research output: Contribution to journal › Article

  102. Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes

    Navarro, M. N., Goebel, J., Feijoo-Carnero, C., Morrice, N. & Cantrell, D. A. Apr-2011 In : Nature Immunology. 12, 4, p. 352-361, 11 p.

    Research output: Contribution to journal › Article

  103. Sensing of energy and nutrients by AMP-activated protein kinase

    Hardie, D. G. Apr-2011 In : American Journal of Clinical Nutrition. 93, 4, p. 891S-896S, 6 p.

    Research output: Contribution to journal › Article

  104. Effect of PI3K-and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKBI-deficient mice

    Garcia-Martinez, J. M., Wullschleger, S., Preston, G., Guichard, S., Fleming, S., Alessi, D. R. & Duce, S. L. 29-Mar-2011 In : British Journal of Cancer. 104, 7, p. 1116-1125, 10 p.

    Research output: Contribution to journal › Article

  105. Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

    Richardson, C., Sakamoto, K., de los Heros, P., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R. 1-Mar-2011 In : Journal of Cell Science. 124, 5, p. 789-800, 12 p.

    Research output: Contribution to journal › Article

  106. Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P-2 in regulating insulin sensitivity defined by knock-in analysis

    Wullschleger, S., Wasserman, D. H., Gray, A., Sakamoto, K. & Alessi, D. R. 1-Mar-2011 In : Biochemical Journal. 434, p. 265-274, 10 p.

    Research output: Contribution to journal › Article

  107. Mechanisms of action of ceramide in different muscle cell lines

    Khoury, R., Turban, S., Loiseau, N., Stretton, C., Lasnier, F., Hundal, H., Ferre, P. & Hajduch, E. Mar-2011 In : Diabetes & Metabolism. 37, s1, p. A30-A30, 1 p., P027

    Research output: Contribution to journal › Book/Film/Article review

  108. Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism

    Macintyre, A. N., Finlay, D., Preston, G., Sinclair, L. V., Waugh, C. M., Tamas, P., Feijoo, C., Okkenhaug, K. & Cantrell, D. A. 25-Feb-2011 In : Immunity. 34, 2, p. 224-236, 13 p.

    Research output: Contribution to journal › Article

  109. AMPK and autophagy get connected

    Hardie, D. G. 16-Feb-2011 In : EMBO Journal. 30, 4, p. 634-635, 2 p.

    Research output: Contribution to journal › Editorial

  110. ERK/p90(RSK)/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicua

    Dissanayake, K., Toth, R., Blakey, J., Olsson, O., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 1-Feb-2011 In : Biochemical Journal. 433, p. 515-525, 11 p.

    Research output: Contribution to journal › Article

  111. A novel transcriptional repressor controlled by Erk/p90RSK/14-3-3 signalling impacts on expression of PEA3 Ets transcription factors

    Dissanayake, K., Toth, R., Olsson, O., Campbell, D., Prescott, A. & MacKintosh, C. Feb-2011 In : Clinical & Experimental Metastasis. 28, 2, p. 234-234, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  112. AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer

    Hardie, D. G. Feb-2011 In : Biochemical Society Transactions. 39, p. 1-13, 13 p.

    Research output: Contribution to journal › Article

  113. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

    Sutherland, C. & 50 others Zhou, K., Bellenguez, C., Spencer, C. C. A., Bennett, A. J., Coleman, R. L., Tavendale, R., Hawley, S. A., Donnelly, L. A., Schofield, C., Groves, C. J., Burch, L., Carr, F., Strange, A., Freeman, C., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Craddock, N., Deloukas, P., Dronov, S., Duncanson, A., Edkins, S., Gray, E., Hunt, S., Jankowski, J., Langford, C., Markus, H. S., Mathew, C. G., Plomin, R., Rautanen, A., Sawcer, S. J., Samani, N. J., Trembath, R., Viswanathan, A. C., Wood, N. W., Harries, L. W., Hattersley, A. T., Doney, A. S. F., Colhoun, H., Morris, A. D., Hardie, D. G., Peltonen, L., McCarthy, M. I., Holman, R. R., Palmer, C. N. A., Donnelly, P., Pearson, E. R. & Wellcome Trust Case Control Consor, GoDARTS UKPDS Diabet Pharmacogenet, MAGIC Investigators Feb-2011 In : Nature Genetics. 43, 2, p. 117-U57, 6 p.

    Research output: Contribution to journal › Article

  114. Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism: Plenary lecture

    Hardie, D. G. Feb-2011 In : Proceedings of the Nutrition Society. 70, 1, p. 92-99, 8 p.

    Research output: Contribution to journal › Article

  115. Hypoxic pulmonary vasoconstriction: mechanisms of oxygen-sensing

    Evans, A. M., Hardie, D. G., Peers, C. & Mahmoud, A. Feb-2011 In : Current Opinion in Anaesthesiology. 24, 1, p. 13-20, 8 p.

    Research output: Contribution to journal › Article

  116. Metabolism, migration and memory in cytotoxic T cells

    Finlay, D. & Cantrell, D. A. Feb-2011 In : Nature Reviews Immunology. 11, 2, p. 109-117, 9 p.

    Research output: Contribution to journal › Article

  117. Why Starving Cells Eat Themselves

    Hardie, D. G. 28-Jan-2011 In : Science. 331, 6016, p. 410-411, 2 p.

    Research output: Contribution to journal › Editorial

  118. Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation?

    Cao, H. & Crocker, P. R. Jan-2011 In : Immunology. 132, 1, p. 18-26, 9 p.

    Research output: Contribution to journal › Article

  119. The coordination of T-cell function by serine/threonine kinases

    Finlay, D. & Cantrell, D. Jan-2011 In : Cold Spring Harbor Perspectives in Biology. 3, 1, p. -, 10 p., a002261

    Research output: Contribution to journal › Article

  120. Chemoenzymatic synthesis of sialooligosaccharides on arrays for studies of cell surface adhesion

    Sardzik, R., Sharma, R., Kaloo, S., Voglmeir, J., Crocker, P. R. & Flitsch, S. L. 2011 In : Chemical Communications. 47, 19, p. 5425-5427, 3 p.

    Research output: Contribution to journal › Article

  121. Hot stuff: thyroid hormones and AMPK

    Hardie, D. G. Dec-2010 In : Cell Research. 20, 12, p. 1282-1284, 3 p.

    Research output: Contribution to journal › Editorial

  122. Investigating the role of murine siglec-E in the modulation of TLR responses and susceptibility to infection

    McKenzie, E. J., Richards, H. E., Zhang, J. Q., Mastroeni, P. & Crocker, P. R. Dec-2010 In : Immunology. 131, s1, p. 82-82, 1 p., 204

    Research output: Contribution to journal › Book/Film/Article review

  123. Mechanism of activation of PKB/Akt by the protein phosphatase inhibitor Calyculin A

    Pozuelo-Rubio, M., Leslie, N. R., Murphy, J. & MacKintosh, C. Dec-2010 In : Cell Biochemistry and Biophysics. 58, 3, p. 147-156, 10 p.

    Research output: Contribution to journal › Article

  124. Myc up-regulates formation of the mRNA methyl cap

    Cowling, V. H. Dec-2010 In : Biochemical Society Transactions. 38, p. 1598-1601, 4 p.

    Research output: Contribution to journal › Scientific review

  125. Siglec-E is a negative regulator of acute pulmonary neutrophil recruitment induced by LPS

    McMillan, S. J., Cao, P., Richards, H. & Crocker, P. R. Dec-2010 In : Immunology. 131, s1, p. 72-72, 1 p., 153

    Research output: Contribution to journal › Book/Film/Article review

  126. Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant V alpha 14 NKT cells and conventional T cells

    Finlay, D. K., Kelly, A. P., Clarke, R., Sinclair, L. V., Deak, M., Alessi, D. R. & Cantrell, D. A. 15-Nov-2010 In : Journal of Immunology. 185, 10, p. 5973-5982, 10 p.

    Research output: Contribution to journal › Article

  127. Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

    Matthews, S. A., Navarro, M. N., Sinclair, L. V., Emslie, E., Feijoo-Carnero, C. & Cantrell, D. A. 15-Nov-2010 In : Biochemical Journal. 432, p. 153-163, 11 p.

    Research output: Contribution to journal › Article

  128. IFI16 is an innate immune sensor for intracellular DNA

    Unterholzner, L., Keating, S. E., Baran, M., Horan, K. A., Jensen, S. B., Sharma, S., Sirois, C. M., Jin, T., Latz, E., Xiao, T. S., Fitzgerald, K. A., Paludan, S. R. & Bowie, A. G. Nov-2010 In : Nature Immunology. 11, 11, p. 997-1004, 8 p.

    Research output: Contribution to journal › Article

  129. Migration Stimulating Factor (MSF) promotes fibroblast migration by inhibiting AKT

    Ellis, I. R., Jones, S. J., Lindsay, Y., Ohe, G., Schor, A. M., Schor, S. L. & Leslie, N. R. Nov-2010 In : Cellular Signalling. 22, 11, p. 1655-1659, 5 p.

    Research output: Contribution to journal › Article

  130. PGC-1 alpha increases PDH content but does not change acute PDH regulation in mouse skeletal muscle

    Kiilerich, K., Adser, H., Jakobsen, A. H., Pedersen, P. A., Hardie, D. G., Wojtaszewski, J. F. P. & Pilegaard, H. Nov-2010 In : American Journal of Physiology: Regulatory Integrative and Comparative Physiology. 299, 5, p. R1350-R1359, 10 p.

    Research output: Contribution to journal › Article

  131. Generation, validation and humanisation of a novel insulin resistant cell model

    Logie, L., Ruiz-Alcaraz, A. J., Schofield, C. J., Hundal, H. S., Feuerstein, G. Z., Brady, J. D., Crowther, D., Tommasi, A. M., Grierson, C. E., Shepherd, B., Morris, A. D., Hansen, M. K., Pearson, E. & Sutherland, C. 1-Oct-2010 In : Biochemical Pharmacology. 80, 7, p. 1042-1049, 8 p.

    Research output: Contribution to journal › Article

  132. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

    Nichols, R. J., Dzamko, N., Morrice, N. A., Campbell, D. G., Deak, M., Ordureau, A., Macartney, T., Tong, Y., Shen, J., Prescott, A. R. & Alessi, D. R. 15-Sep-2010 In : Biochemical Journal. 430, p. 393-404, 12 p.

    Research output: Contribution to journal › Article

  133. Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

    Dzamko, N., Deak, M., Hentati, F., Reith, A. D., Prescott, A. R., Alessi, D. R. & Nichols, R. J. 15-Sep-2010 In : Biochemical Journal. 430, p. 405-413, 9 p.

    Research output: Contribution to journal › Article

  134. Targeting the Core of Transcription

    Hardie, D. G. 3-Sep-2010 In : Science. 329, 5996, p. 1158-1159, 2 p.

    Research output: Contribution to journal › Editorial

  135. Activating K-Ras mutations outwith "hotspot" codons in sporadic colorectal tumours: implications for personalised cancer medicine

    Smith, G., Bounds, R., Wolf, H., Pratt, N., Carey, F., Steele, R. & Wolf, C. Sep-2010 In : Journal of Pathology. 222, S1, p. S12-S12, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  136. Cellular depletion of atypical PKC lambda is associated with enhanced insulin sensitivity and glucose uptake in L6 rat skeletal muscle cells

    Stretton, C., Evans, A. & Hundal, H. S. Sep-2010 In : American Journal of Physiology, Endocrinology and Metabolism. 299, 3, p. E402-E412, 11 p.

    Research output: Contribution to journal › Article

  137. In vivo evidence for the involvement of the carboxy terminal domain in assembling connexin 36 at the electrical synapse

    Helbig, I., Sammler, E., Eliava, M., Bolshakov, A. P., Rozov, A., Bruzzone, R., Monyer, H. & Hormuzdi, S. G. Sep-2010 In : Molecular and Cellular Neuroscience. 45, 1, p. 47-58, 12 p.

    Research output: Contribution to journal › Article

  138. PTEN and Cancer

    Leslie, N. Sep-2010 In : Journal of Pathology. 222, S1, p. S2-S2, 1 p.

    Research output: Contribution to journal › Meeting abstract

  139. The Laforin-Malin Complex, Involved in Lafora Disease, Promotes the Incorporation of K63-linked Ubiquitin Chains into AMP-activated Protein Kinase beta Subunits

    Moreno, D., Towler, M. C., Hardie, D. G., Knecht, E. & Sanz, P. 1-Aug-2010 In : Molecular Biology of the Cell. 21, 15, p. 2578-2588, 11 p.

    Research output: Contribution to journal › Article

  140. A fluorescence lifetime-based assay for serine and threonine kinases that is suitable for high-throughput screening

    Paterson, M. J., Dunsmore, C. J., Hurteaux, R., Maltman, B. A., Cotton, G. J. & Gray, A. 1-Jul-2010 In : Analytical Biochemistry. 402, 1, p. 54-64, 11 p.

    Research output: Contribution to journal › Article

  141. Characterization of the specific interaction between sialoadhesin and sialylated Campylobacter jejuni lipooligosaccharides

    Heikema, A. P., Bergman, M. P., Richards, H., Crocker, P. R., Gilbert, M., Samsom, J. N., van Wamel, W. J. B., Endtz, H. P. & van Belkum, A. Jul-2010 In : Infection and Immunity. 78, 7, p. 3237-3246, 10 p.

    Research output: Contribution to journal › Article

  142. Reactive oxygen species alters the electrophysiological properties and raises [Ca2+](i) in intracardiac ganglion neurons

    Dyavanapalli, J., Rimmer, K. & Harper, A. A. Jul-2010 In : American Journal of Physiology: Regulatory Integrative and Comparative Physiology. 299, 1, p. R42-R54, 13 p.

    Research output: Contribution to journal › Article

  143. Activity of any class IA PI3K isoform can sustain cell proliferation and survival

    Foukas, L. C., Berenjeno, I. M., Gray, A., Khwaja, A. & Vanhaesebroeck, B. 22-Jun-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11381-11386, 6 p.

    Research output: Contribution to journal › Article

  144. Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase

    Mankouri, J., Tedbury, P. R., Gretton, S., Hughes, M. E., Griffin, S. D. C., Dallas, M. L., Green, K. A., Hardie, D. G., Peers, C. & Harris, M. 22-Jun-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11549-11554, 6 p.

    Research output: Contribution to journal › Article

  145. Use of Cells Expressing gamma Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

    Hawley, S. A., Ross, F. A., Chevtzoff, C., Green, K. A., Evans, A., Fogarty, S., Towler, M. C., Brown, L. J., Ogunbayo, O. A., Evans, A. M. & Hardie, D. G. 9-Jun-2010 In : Cell Metabolism. 11, 6, p. 554-565, 12 p.

    Research output: Contribution to journal › Article

  146. Mechanisms involved in the enhancement of mammalian target of rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice

    Lipina, C., Kendall, H., McPherron, A. C., Taylor, P. M. & Hundal, H. S. 3-Jun-2010 In : FEBS Letters. 584, 11, p. 2403-2408, 6 p.

    Research output: Contribution to journal › Article

  147. Myc regulation of mRNA cap methylation

    Cowling, V. H. & Cole, M. D. Jun-2010 In : Genes and Cancer. 1, 6, p. 576-579, 4 p.

    Research output: Contribution to journal › Scientific review

  148. Dendritic cell podosomes are protrusive and invade the extracellular matrix using metalloproteinase MMP-14

    Gawden-Bone, C., Zhou, Z., King, E., Prescott, A., Watts, C. & Lucocq, J. 1-May-2010 In : Journal of Cell Science. 123, 9, p. 1427-1437, 11 p.

    Research output: Contribution to journal › Article

  149. Tryptophan and iodothyronine transport interactions in HepG2 human hepatoma cells

    Ritchie, J. W. A. & Taylor, P. M. May-2010 In : Amino Acids. 38, 5, p. 1361-1367, 7 p.

    Research output: Contribution to journal › Article

  150. Ubiquitination of PTEN (Phosphatase and Tensin Homolog) Inhibits Phosphatase Activity and Is Enhanced by Membrane Targeting and Hyperosmotic Stress

    Maccario, H., Perera, N. M., Gray, A., Downes, C. P. & Leslie, N. R. 23-Apr-2010 In : Journal of Biological Chemistry. 285, 17, p. 12620-12628, 9 p.

    Research output: Contribution to journal › Article

  151. Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction

    Loubiere, L. S., Vasilopoulou, E., Bulmer, J. N., Taylor, P. M., Stieger, B., Verrey, F., McCabe, C. J., Franklyn, J. A., Kilby, M. D. & Chan, S-Y. Apr-2010 In : Placenta. 31, 4, p. 295-304, 10 p.

    Research output: Contribution to journal › Article

  152. New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion

    Zagorska, A., Deak, M., Campbell, D. G., Banerjee, S., Hirano, M., Aizawa, S., Prescott, A. R. & Alessi, D. R. 30-Mar-2010 In : Science Signaling. 3, 115, p. -, 13 p., ra25

    Research output: Contribution to journal › Article

  153. Leptin Regulates AMPA Receptor Trafficking via PTEN Inhibition

    Moult, P. R., Cross, A., Santos, S. D., Carvalho, A-L., Lindsay, Y., Connolly, C. N., Irving, A. J., Leslie, N. R. & Harvey, J. 17-Mar-2010 In : Journal of Neuroscience. 30, 11, p. 4088-4101, 14 p.

    Research output: Contribution to journal › Article

  154. Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase

    Hurtado-Guerrero, R., Zusman, T., Pathak, S., Ibrahim, A. F. M., Shepherd, S., Prescott, A., Segal, G. & van Aalten, D. M. F. 15-Mar-2010 In : Biochemical Journal. 426, p. 281-292, 12 p.

    Research output: Contribution to journal › Article

  155. Distinct Protease Requirements for Antigen Presentation In Vitro and In Vivo

    Matthews, S. P., Werber, I., Deussing, J., Peters, C., Reinheckel, T. & Watts, C. 1-Mar-2010 In : Journal of Immunology. 184, 5, p. 2423-2431, 9 p.

    Research output: Contribution to journal › Article

  156. Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer

    Fogarty, S. & Hardie, D. G. Mar-2010 In : Biochimica et Biophysica Acta. Proteins and Proteomics. 1804, 3, p. 581-591, 11 p.

    Research output: Contribution to journal › Article

  157. Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours: implications for personalised cancer medicine

    Smith, G., Bounds, R., Wolf, H., Steele, R., Carey, F. & Wolf, R. 16-Feb-2010 In : British Journal of Cancer. 102, 4, p. 693-703, 11 p.

    Research output: Contribution to journal › Article

  158. Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP

    Fogarty, S., Hawley, S. A., Green, K. A., Saner, N., Mustard, K. J. & Hardie, D. G. 15-Feb-2010 In : Biochemical Journal. 426, p. 109-118, 10 p.

    Research output: Contribution to journal › Article

  159. Enhanced mRNA cap methylation increases Cyclin D1 expression and promotes cell transformation

    Cowling, V. H. 11-Feb-2010 In : Oncogene. 29, 6, p. 930-936, 7 p.

    Research output: Contribution to journal › Article

  160. Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN

    Davidson, L., Maccario, H., Perera, N. M., Yang, X., Spinelli, L., Tibarewal, P., Glancy, B., Gray, A., Weijer, C. J., Downes, C. P. & Leslie, N. R. 4-Feb-2010 In : Oncogene. 29, 5, p. 687-697, 11 p.

    Research output: Contribution to journal › Article

  161. Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein

    Hale, B. G., Kerry, P. S., Jackson, D., Precious, B. L., Gray, A., Killip, M. J., Randall, R. E. & Russell, R. J. 2-Feb-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 5, p. 1954-1959, 6 p.

    Research output: Contribution to journal › Article

  162. MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages

    Darragh, J., Ananieva, O., Courtney, A., Elcombe, S. & Arthur, J. S. C. 1-Feb-2010 In : Biochemical Journal. 425, p. 595-602, 8 p.

    Research output: Contribution to journal › Article

  163. Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser(517)/Ser(520) in glucose-stimulated insulin granule movement

    McDonald, A., Fogarty, S., Leclerc, I., Hill, E. V., Hardie, D. G. & Rutter, G. A. Feb-2010 In : Biochemical Society Transactions. 38, p. 205-208, 4 p.

    Research output: Contribution to journal › Article

  164. Prevention of high-fat diet-induced muscular lipid accumulation in rats by alpha lipoic acid is not mediated by AMPK activation

    Timmers, S., de Vogel-van den Bosch, J., Towler, M. C., Schaart, G., Moonen-Kornips, E., Mensink, R. P., Hesselink, M. K., Hardie, D. G. & Schrauwen, P. Feb-2010 In : Journal of Lipid Research. 51, 2, p. 352-359, 8 p.

    Research output: Contribution to journal › Article

  165. Regulation of MAP Kinase-Directed Mitogenic and Protein Kinase B-Mediated Signaling by Cannabinoid Receptor Type 1 in Skeletal Muscle Cells

    Lipina, C., Stretton, C., Hastings, S., Hundal, J. S., Mackie, K., Irving, A. J. & Hundal, H. S. Feb-2010 In : Diabetes. 59, 2, p. 375-385, 11 p.

    Research output: Contribution to journal › Article

  166. TLR signalling regulated antigen presentation in dendritic cells

    Watts, C., West, M. A. & Zaru, R. Feb-2010 In : Current Opinion in Immunology. 22, 1, p. 124-130, 7 p.

    Research output: Contribution to journal › Scientific review

  167. Regulation of mRNA cap methylation

    Cowling, V. H. 15-Jan-2010 In : Biochemical Journal. 425, p. 295-302, 8 p.

    Research output: Contribution to journal › Scientific review

  168. Legumain and cathepsin-L expression in human unstable carotid plaque

    Mattock, K. L., Gough, P. J., Humphries, J., Burnand, K., Patel, L., Suckling, K. E., Cuello, F., Watts, C., Gautel, M., Avkiran, M. & Smith, A. Jan-2010 In : Atherosclerosis. 208, 1, p. 83-89, 7 p.

    Research output: Contribution to journal › Article

  169. LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells

    Tamas, P., Macintyre, A., Finlay, D., Clarke, R., Feijoo-Carnero, C., Ashworth, A. & Cantrell, D. Jan-2010 In : European Journal of Immunology. 40, 1, p. 242-253, 12 p.

    Research output: Contribution to journal › Article

  170. Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration

    Finlay, D. & Cantrell, D. Jan-2010 In : Annals of the New York Academy of Sciences. 1183, p. 149-157, 9 p.

    Research output: Contribution to journal › Article

  171. Analyzing the multiple mechanisms by which drugs and other xenobiotic compounds activate AMP-activated protein kinase

    Hardie, D. G. 2010 In : Therapeutic Research. 31, 6, p. 822-835, 14 p.

    Research output: Contribution to journal › Article

  172. Cancer metabolism as a potential treatment target

    Hardie, G. 2010 In : Annals of Oncology. 21, Suppl. 4, p. iv21-iv21, 1 p., 3IN

    Research output: Contribution to journal › Meeting abstract

  173. Cancer metabolism as a potential treatment target

    Hardie, G. 2010

    Research output: Contribution to conference › Paper

  174. Iodothyronine Interactions with the System L1 Amino Acid Exchanger in 3T3-L1 Adipocytes

    Mitchell, F., Roy, L. A. & Taylor, P. M. 2010 In : Journal of Thyroid Research. 2010, 8 p., 726098

    Research output: Contribution to journal › Article

  175. Regulation of mammary epithelial architecture by PTEN

    Lim, J. C., Davidson, L., Weerasinghe, N. R., Zilidis, G., Tibarewal, P., Spinelli, L. & Leslie, N. R. 2010 In : Breast Cancer Research. 12, p. S3-S3, 1 p., P4

    Research output: Contribution to journal › Meeting abstract

  176. Expression and modulation of TUB by insulin and thyroid hormone in primary rat and murine 3T3-L1 adipocytes

    Stretton, C., Litherland, G. J., Moynihan, A., Hajduch, E. & Hundal, H. S. 25-Dec-2009 In : Biochemical and Biophysical Research Communications. 390, 4, p. 1328-1333, 6 p.

    Research output: Contribution to journal › Article

  177. S-Adenosyl Homocysteine Hydrolase Is Required for Myc-Induced mRNA Cap Methylation, Protein Synthesis, and Cell Proliferation

    Fernandez-Sanchez, M. E., Gonatopoulos-Pournatzis, T., Preston, G., Lawlor, M. A. & Cowling, V. H. 1-Dec-2009 In : Molecular and Cellular Biology. 29, 23, p. 6182-6191, 10 p.

    Research output: Contribution to journal › Article

  178. Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation

    Waugh, C., Sinclair, L., Finlay, D., Bayascas, J. R. & Cantrell, D. 1-Nov-2009 In : Molecular and Cellular Biology. 29, 21, p. 5952-5962, 11 p.

    Research output: Contribution to journal › Article

  179. Diverse regulatory roles for lysosomal proteases in the immune response

    Colbert, J. D., Matthews, S. P., Miller, G. & Watts, C. Nov-2009 In : European Journal of Immunology. 39, 11, p. 2955-2965, 11 p.

    Research output: Contribution to journal › Scientific review

  180. Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

    Finlay, D. K., Sinclair, L. V., Feijoo, C., Waugh, C. M., Hagenbeek, T. J., Spits, H. & Cantrell, D. A. 26-Oct-2009 In : Journal of Experimental Medicine. 206, 11, p. 2441-2454, 14 p.

    Research output: Contribution to journal › Article

  181. Reactive oxygen species modulate neuronal excitability in rat intrinsic cardiac ganglia

    Whyte, K. A., Hogg, R. C., Dyavanapalli, J., Harper, A. A. & Adams, D. J. 5-Oct-2009 In : Autonomic Neuroscience: Basic & Clinical. 150, 1-2, p. 45-52, 8 p.

    Research output: Contribution to journal › Article

  182. Association of AMP-activated Protein Kinase Subunits With Glycogen Particles as Revealed In Situ by Immunoelectron Microscopy

    Bendayan, M., Londono, I., Kemp, B. E., Hardie, G. D., Ruderman, N. & Prentki, M. Oct-2009 In : Journal of Histochemistry & Cytochemistry. 57, 10, p. 963-971, 9 p.

    Research output: Contribution to journal › Article

  183. ABC50 promotes translation initiation in mammalian cells

    Paytubi, S., Wang, X., Lam, Y. W., Izquierdo, L., Hunter, M. J., Jan, E., Hundal, H. S. & Proud, C. G. 4-Sep-2009 In : Journal of Biological Chemistry. 284, 36, p. 24061-24073, 13 p.

    Research output: Contribution to journal › Article

  184. Histological evaluation of AMPK signalling in primary breast cancer

    Hadad, S. M., Baker, L., Quinlan, P. R., Robertson, K. E., Bray, S. E., Thomson, G., Kellock, D., Jordan, L. B., Purdie, C. A., Hardie, D. G., Fleming, S. & Thompson, A. M. 1-Sep-2009 In : BMC Cancer. 9, p. -, 9 p., 307

    Research output: Contribution to journal › Article

  185. Circulating neopterin and monocyte chemoattractant protein-1 are responsive to statin therapy but are poor predictors of cardiovascular events in type 2 diabetes in CARDS

    Colhoun, H. M., Betteridge, D. J., Durrington, P. N., Hitman, G., Neil, H. A. W., Charlton-Menys, V., Bao, W., DeMicco, D., Preston, G., Livingstone, S. & Fuller, J. H. Sep-2009 In : Diabetologia. 52, Supplement 1, p. S481-S481, 1 p., 1247

    Research output: Contribution to journal › Book/Film/Article review

  186. Fate of Glycosylphosphatidylinositol (GPI)-Less Procyclin and Characterization of Sialylated Non-GPI-Anchored Surface Coat Molecules of Procyclic-Form Trypanosoma brucei

    Guether, M. L. S., Beattie, K., Lamont, D. J., James, J., Prescott, A. R. & Ferguson, M. A. J. Sep-2009 In : Eukaryotic Cell. 8, 9, p. 1407-1417, 11 p.

    Research output: Contribution to journal › Article

  187. Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

    Pehmoller, C., Treebak, J. T., Birk, J. B., Chen, S., MacKintosh, C., Hardie, D. G., Richter, E. A. & Wojtaszewski, J. F. P. Sep-2009 In : American Journal of Physiology, Endocrinology and Metabolism. 297, 3, p. E665-E675, 11 p.

    Research output: Contribution to journal › Article

  188. Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes

    Baird, F. E., Bett, K. J., MacLean, C., Tee, A. R., Hundal, H. S. & Taylor, P. M. Sep-2009 In : American Journal of Physiology, Endocrinology and Metabolism. 297, 3, p. E822-E829, 8 p.

    Research output: Contribution to journal › Article

  189. Novel MHC Class I Structures on Exosomes

    Lynch, S., Santos, S. G., Campbell, E. C., Nimmo, A. M. S., Botting, C., Prescott, A., Antoniou, A. N. & Powis, S. J. 1-Aug-2009 In : Journal of Immunology. 183, 3, p. 1884-1891, 8 p.

    Research output: Contribution to journal › Article

  190. Decreasing amputation rates in patients with diabetes-a population-based study

    Schofield, C. J., Yu, N., Jain, A. S. & Leese, G. P. Aug-2009 In : Diabetic Medicine. 26, 8, p. 773-777, 5 p.

    Research output: Contribution to journal › Article

  191. The developmental mutant talpid(3) lacks primary cilia

    Bangs, F., Yin, Y., Paton, R., Prescott, A., James, J., Davey, M., Whitley, P., Genikhovich, G., Technau, U., Briscoe, J., Burt, D. & Tickle, C. Aug-2009 In : Mechanisms of Development. 126, p. S262-S262, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  192. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

    Garcia-Martinez, J. M., Moran, J., Clarke, R. G., Gray, A., Cosulich, S. C., Chresta, C. M. & Alessi, D. R. 1-Jul-2009 In : Biochemical Journal. 421, p. 29-42, 14 p.

    Research output: Contribution to journal › Article

  193. A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase

    Patel, N., Krishnan, S., Offman, M. N., Krol, M., Moss, C. X., Leighton, C., van Delft, F. W., Holland, M., Liu, J., Alexander, S., Dempsey, C., Ariffin, H., Essink, M., Eden, T. O. B., Watts, C., Bates, P. A. & Saha, V. Jul-2009 In : Journal of Clinical Investigation. 119, 7, p. 1964-1973, 10 p.

    Research output: Contribution to journal › Article

  194. Sensing and signaling functions associated with the SNAT2 amino acid transporter

    Hundal, H., Cwiklinski, E. & Taylor, P. M. Jul-2009 In : Amino Acids. 37, Suppl. 1, p. S8, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  195. AMP-activated protein kinase: a sensor of glycogen as well as AMP and ATP?

    McBride, A. & Hardie, D. G. May-2009 In : Acta Physiologica. 196, 1, p. 99-113, 15 p.

    Research output: Contribution to journal › Scientific review

  196. Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status

    Babraj, J. A., Mustard, K., Sutherland, C., Towler, M. C., Chen, S., Smith, K., Green, K., Leese, G., Hardie, D. G., Rennie, M. J. & Cuthbertson, D. J. May-2009 In : American Journal of Physiology, Endocrinology and Metabolism. 296, 5, p. E1042-E1048, 7 p.

    Research output: Contribution to journal › Article

  197. Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle

    Treebak, J. T., Frosig, C., Pehmoller, C., Chen, S., Maarbjerg, S. J., Brandt, N., MacKintosh, C., Zierath, J. R., Hardie, D. G., Kiens, B., Richter, E. A., Pilegaard, H. & Wojtaszewski, J. F. P. May-2009 In : Diabetologia. 52, 5, p. 891-900, 10 p.

    Research output: Contribution to journal › Article

  198. Activated cAMP receptors switch encystation into sporulation

    Kawabe, Y., Morio, T., James, J. L., Prescott, A. R., Tanaka, Y. & Schaap, P. 28-Apr-2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 17, p. 7089-7094, 6 p.

    Research output: Contribution to journal › Article

  199. 444 A potential regulatory role for cathepsin V and its cognate inhibitor cystatin M/E in epidermal desquamation

    Cheng, T., Dolk, C., Caubet, C., Simon, M., Watts, C., Kamsteeg, M., Serre, G., Schalkwijk, J. & Zeeuwen, P. L. Apr-2009 In : Journal of Investigative Dermatology. 129, p. S74-S74, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  200. Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling

    Hundal, H. S. & Taylor, P. M. Apr-2009 In : American Journal of Physiology, Endocrinology and Metabolism. 296, 4, p. E603-E613, 11 p.

    Research output: Contribution to journal › Scientific review

  201. Glycosylation Directs Targeting and Activation of Cystatin F from Intracellular and Extracellular Sources

    Colbert, J. D., Plechanovova, A. & Watts, C. Apr-2009 In : Traffic. 10, 4, p. 425-437, 13 p.

    Research output: Contribution to journal › Article

  202. Phenotype and genotype of a patient with McLeod syndrome

    Sammler, E., O'Riordan, J., Swingler, R., Poole, J. & Hormuzdi, S. G. Apr-2009 In : Journal of Neurology, Neurosurgery and Psychiatry. 80, 4, p. 456-456, 1 p., CP4

    Research output: Contribution to journal › Book/Film/Article review

  203. hnRNP-U is a specific DNA-dependent protein kinase substrate phosphorylated in response to DNA double-strand breaks

    Berglund, F. M. & Clarke, P. R. 27-Mar-2009 In : Biochemical and Biophysical Research Communications. 381, 1, p. 59-64, 6 p.

    Research output: Contribution to journal › Article

  204. Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo

    Rajkhowa, M., Brett, S., Cuthbertson, D. J., Lipina, C., Ruiz-Alcaraz, A. J., Thomas, G. E., Logie, L., Petrie, J. R. & Sutherland, C. 15-Mar-2009 In : Biochemical Journal. 418, p. 665-671, 7 p.

    Research output: Contribution to journal › Article

  205. Specific regulation of mRNA cap methylation by the c-Myc and E2F1 transcription factors

    Cole, M. D. & Cowling, V. H. 5-Mar-2009 In : Oncogene. 28, 9, p. 1169-1175, 7 p.

    Research output: Contribution to journal › Article

  206. The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors

    Zhang, Y., Lucocq, J. M. & Hayes, J. D. 1-Mar-2009 In : Biochemical Journal. 418, p. 293-310, 18 p.

    Research output: Contribution to journal › Article

  207. The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation

    Yin, Y., Bangs, F., Paton, I. R., Prescott, A., James, J., Davey, M. G., Whitley, P., Genikhovich, G., Technau, U., Burt, D. W. & Tickle, C. 15-Feb-2009 In : Development. 136, 4, p. 655-664, 10 p.

    Research output: Contribution to journal › Article

  208. Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells

    Watson, M. L., Coghlan, M. & Hundal, H. S. 1-Feb-2009 In : Biochemical Journal. 417, p. 791-801, 11 p.

    Research output: Contribution to journal › Article

  209. The action of high K+ and aglycaemia on the electrical properties and synaptic transmission in rat intracardiac ganglion neurones in vitro

    Dyavanapalli, J., Rimmer, K. & Harper, A. A. 1-Feb-2009 In : Experimental Physiology. 94, 2, p. 201-212, 12 p.

    Research output: Contribution to journal › Article

  210. Amino acid transporters: eminences grises of nutrient signalling mechanisms?

    Taylor, P. M. Feb-2009 In : Biochemical Society Transactions. 37, p. 237-241, 5 p.

    Research output: Contribution to journal › Article

  211. The Glycogen-Binding Domain on the AMPK beta Subunit Allows the Kinase to Act as a Glycogen Sensor

    McBride, A., Ghilagaber, S., Nikolaev, A. & Hardie, D. G. 7-Jan-2009 In : Cell Metabolism. 9, 1, p. 23-34, 12 p.

    Research output: Contribution to journal › Article

  212. C-terminal Phosphorylation of LKB1 Is Not Required for Regulation of AMP-activated Protein Kinase, BRSK1, BRSK2, or Cell Cycle Arrest

    Fogarty, S. & Hardie, D. G. 2-Jan-2009 In : Journal of Biological Chemistry. 284, 1, p. 77-84, 8 p.

    Research output: Contribution to journal › Article

  213. mVps34 is activated following high-resistance contractions

    MacKenzie, M. G., Hamilton, D. L., Murray, J. T., Taylor, P. M. & Baar, K. 1-Jan-2009 In : Journal of Physiology. 587, 1, p. 253-260, 8 p.

    Research output: Contribution to journal › Article

  214. A core MYC gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response

    Chandriani, S., Frengen, E., Cowling, V. H., Pendergrass, S. A., Perou, C. M., Whitfield, M. L. & Cole, M. D. 2009 In : PLoS ONE. 4, 8, e6693

    Research output: Contribution to journal › Article

  215. AMP-activated protein kinase monitors respiratory gases as an index of respiratory function and energy supply at the whole-body level

    Evans, A. M., Peers, C. & Hardie, D. G. 2009 In : Journal of Physiological Sciences. 59, p. 405-405, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  216. Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation

    McDonald, A., Fogarty, S., Leclerc, I., Hill, E. V., Hardie, D. G. & Rutter, G. A. 2009 In : Islets. 1, 3, p. 198-209, 12 p.

    Research output: Contribution to journal › Article

  217. Ion Channel Regulation by AMPK: The Route of Hypoxia-Response Coupling in the Carotid Body and Pulmonary Artery

    Evans, A. M., Hardie, D. G., Peers, C., Wyatt, C. N., Viollet, B., Kumar, P., Dallas, M. L., Ross, F., Ikematsu, N., Jordan, H. L., Barr, B. L., Rafferty, J. N. & Ogunbayo, O. 2009 Hypoxia and Consequences From Molecule to Malady. Peers, C., Haddad, G. G. & Chandel, N. S. (eds.). Oxford: Blackwell, p. 89-100 12 p. (Annals of the New York Academy of Sciences).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  218. Modulation of O-2 Sensitive K+ Channels by AMP-activated Protein Kinase

    Dallas, M. L., Scragg, J. L., Wyatt, C. N., Ross, F., Hardie, D. G., Evans, A. M. & Peers, C. 2009 Arterial Chemoreceptors. Gonzalez, C., Nurse, C. A. & Peers, C. (eds.). BERLIN: Springer, p. 57-63 7 p. (Advances in Experimental Medicine and Biology).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  219. Roles of the AMP-activated/SNF1 protein kinase family in the response to cellular stress

    Hardie, D. G. 2009 Cellular responses to stress. Downes, C. P., Wolf, C. R. & Lane, D. P. (eds.). London: Portland Press Ltd, p. 13-27 (Biochemical Society symposia; 64).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  220. Sensing of energy availability by the AMP-activated protein kinase

    Hardie, D. G. & McBride, A. 2009 In : Journal of Physiological Sciences. 59, p. 61-61, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  221. The significance of PTEN's protein phosphatase activity

    Leslie, N. R., Maccario, H., Spinelli, L. & Davidson, L. 2009 In : Advances in Enzyme Regulation. 49, 1, p. 190-196, 7 p.

    Research output: Contribution to journal › Article

  222. Viral evasion and subversion of pattern-recognition receptor signalling

    Bowie, A. G. & Unterholzner, L. Dec-2008 In : Nature Reviews Immunology. 8, 12, p. 911-22, 12 p.

    Research output: Contribution to journal › Article

  223. A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

    Towler, M. C., Fogarty, S., Hawley, S. A., Pan, D. A., Martin, D. M. A., Morrice, N. A., McCarthy, A., Galardo, M. N., Meroni, S. B., Cigorraga, S. B., Ashworth, A., Sakamoto, K. & Hardie, D. G. 15-Nov-2008 In : Biochemical Journal. 416, p. 114, 14 p.

    Research output: Contribution to journal › Article

  224. Ketoacidosis with pulmonary embolism: a formula to detect clots?

    Kidder, D., Pearson, E., Davidson, J., Swaminathan, K. & Petrie, J. R. 1-Nov-2008 In : British Journal of Diabetes and Vascular Disease. 8, 6, p. 301, 1 p.

    Research output: Contribution to journal › Article

  225. Reactive Oxygen Species increases Intracellular Calcium, alters the Electrophysiological Properties and Synaptic Transmission In Intrinsic Cardiac Ganglion Neurons: in vitro

    Dyavanapalli, J., Rimmer, K. & Harper, A. A. 28-Oct-2008 In : Circulation. 118, 18, p. S359-S359, 1 p., 1623

    Research output: Contribution to journal › Book/Film/Article review

  226. AMP-activated protein kinase and hypoxic pulmonary vasoconstriction

    Robertson, T. P., Mustard, K. J. W., Lewis, T. H., Clark, J. H., Wyatt, C. N., Blanco, E. A., Peers, C., Hardie, D. G. & Evans, A. M. 24-Oct-2008 In : European Journal of Pharmacology. 595, 1-3, p. 39-43, 5 p.

    Research output: Contribution to journal › Article

  227. Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

    Green, C. J., Goransson, O., Kular, G. S., Leslie, N. R., Gray, A., Alessi, D. R., Sakamoto, K. & Hundal, H. S. 10-Oct-2008 In : Journal of Biological Chemistry. 283, 41, p. 27653-27667, 15 p.

    Research output: Contribution to journal › Article

  228. Small molecules can have big effects on endurance

    Baar, K. & Hardie, D. G. Oct-2008 In : Nature Chemical Biology. 4, 10, p. 583-584, 3 p.

    Research output: Contribution to journal › Comment/debate

  229. Transcription-independent functions of MYC: regulation of translation and DNA replication

    Cole, M. D. & Cowling, V. H. Oct-2008 In : Nature Reviews Molecular Cell Biology. 9, 10, p. 810-815, 6 p.

    Research output: Contribution to journal › Scientific review

  230. Understanding PTEN regulation: PIP, polarity and protein stability

    Leslie, N. R., Batty, I. H., Maccario, H., Davidson, L. & Downes, C. P. 15-Sep-2008 In : Oncogene. 27, 41, p. 5464-5476, 13 p.

    Research output: Contribution to journal › Article

  231. TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent

    West, M. A., Prescott, A. R., Chan, K. M., Zhou, Z., Rose-John, S., Scheller, J. & Watts, C. 8-Sep-2008 In : Journal of Cell Biology. 182, 5, p. 993-1005, 13 p.

    Research output: Contribution to journal › Article

  232. AMPK: a key regulator of energy balance in the single cell and the whole organism

    Hardie, D. G. Sep-2008 In : International Journal of Obesity. 32, p. S7-S12, 6 p.

    Research output: Contribution to journal › Article

  233. CD33-related sialic-acid-binding immunoglobulin-like lectins in health and disease

    McMillan, S. J. & Crocker, P. R. 11-Aug-2008 In : Carbohydrate Research. 343, 12, p. 2050-2056, 7 p.

    Research output: Contribution to journal › Article

  234. The orphan adapter protein SLY1 as a novel anti-apoptotic protein required for thymocyte development

    Reis, B., Finkenstaedt, D., Finlay, D. K., Cantrell, D. A., Pfeffer, K. & Beer, S. Aug-2008 In : Wiener Klinische Wochenschrift. 120, Supplement 1, p. 20-20, 1 p., 057

    Research output: Contribution to journal › Book/Film/Article review

  235. Expression and localisation of apical junctional complex proteins in lens epithelial cells

    Sugiyama, Y., Prescott, A. R., Tholozan, F. M. D., Ohno, S. & Quinlan, R. A. Jul-2008 In : Experimental Eye Research. 87, 1, p. 64-70, 7 p.

    Research output: Contribution to journal › Article

  236. Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression

    Hines, R. M., Wu, L., Hines, D. J., Steenland, H., Mansour, S., Dahlhaus, R., Singaraja, R. R., Cao, X., Sammler, E., Hormuzdi, S. G., Zhuo, M. & El-Husseini, A. 11-Jun-2008 In : Journal of Neuroscience. 28, 24, p. 6055-6067, 13 p.

    Research output: Contribution to journal › Article

  237. The synthesis of UDP-N-acetylglucosamine is essential for bloodstream form Trypanosoma brucei in vitro and in vivo and UDP-N-acetylglucosamine starvation reveals a hierarchy in parasite protein glycosylation

    Stokes, M. J., Guther, M. L. S., Turnock, D. C., Prescott, A. R., Martin, K. L., Alphey, M. S. & Ferguson, M. A. J. 6-Jun-2008 In : Journal of Biological Chemistry. 283, 23, p. 16147-16161, 15 p.

    Research output: Contribution to journal › Article

  238. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

    Sauer, S., Bruno, L., Hertweck, A., Finlay, D., Leleu, M., Spivakov, M., Knight, Z. A., Cobb, B. S., Cantrell, D., O'Connor, E., Shokat, K. M., Fisher, A. G. & Merkenschlager, M. 3-Jun-2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 22, p. 7797-7802, 6 p.

    Research output: Contribution to journal › Article

  239. AMPK and raptor: matching cell growth to energy supply

    Hardie, D. G. 9-May-2008 In : Molecular Cell. 30, 3, p. 263-265, 3 p.

    Research output: Contribution to journal › Editorial

  240. Cromakalim activates the K-ATP and enhances spontaneous transient outward potassium currents in rat saphenous arterial myocytes

    Fioretti, B., Trequattrini, C., Sforna, L., Harper, A., Catacuzzeno, L. & Franciolini, F. May-2008 In : Pharmacological Research. 57, 5, p. 398-402, 5 p.

    Research output: Contribution to journal › Article

  241. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

    Bayascas, J. R., Wullschleger, S., Sakamoto, K., Garcia-Martinez, J. M., Clacher, C., Komander, D., van Aalten, D. M. F., Boini, K. M., Lan, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., van Diepen, J. A., Voshol, P. J., Lucocq, J. M. & Alessi, D. R. May-2008 In : Molecular and Cellular Biology. 28, 10, p. 3258-3272, 15 p.

    Research output: Contribution to journal › Article

  242. Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

    Sinclair, L. V., Finlay, D., Feijoo, C., Cornish, G. H., Gray, A., Ager, A., Okkenhaug, K., Hagenbeek, T. J., Spits, H. & Cantrell, D. A. May-2008 In : Nature Immunology. 9, 5, p. 513-521, 9 p.

    Research output: Contribution to journal › Article

  243. Location, location, location: identifying the neighborhoods of LPS signaling

    Watts, C. Apr-2008 In : Nature Immunology. 9, 4, p. 343-345, 3 p.

    Research output: Contribution to journal › Editorial

  244. Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice

    Mooney, M. H., Fogarty, S., Stevenson, C., Gallagher, A. M., Palit, P., Hawley, S. A., Hardie, D. G., Coxon, G. D., Waigh, R. D., Tate, R. J., Harvey, A. L. & Furman, B. L. Apr-2008 In : British Journal of Pharmacology. 153, 8, p. 1669-1677, 9 p.

    Research output: Contribution to journal › Article

  245. Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase

    Liu, Z., Jang, S-W., Liu, X., Cheng, D., Peng, J., Yepes, M., Li, X., Matthews, S., Watts, C., Asano, M., Hara-Nishimura, I., Luo, H. R. & Ye, K. 28-Mar-2008 In : Molecular Cell. 29, 6, p. 665-678, 14 p.

    Research output: Contribution to journal › Article

  246. Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha 1 following overload in LKB1 knockout mice

    Mcgee, S. L., Mustard, K. J., Hardie, D. G. & Baar, K. 15-Mar-2008 In : Journal of Physiology. 586, 6, p. 1731-1741, 11 p.

    Research output: Contribution to journal › Article

  247. Targeting of PKC zeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

    Hajduch, E., Turban, S., Le Liepvre, X., Le Lay, S., Lipina, C., Dimopoulos, N., Dugail, I. & Hundal, H. S. 1-Mar-2008 In : Biochemical Journal. 410, p. 369-379, 11 p.

    Research output: Contribution to journal › Article

  248. A role for ARF6 in dendritic cell podosome formation and migration

    Svensson, H. G., West, M. A., Mollahan, P., Prescott, A. R., Zaru, R. & Watts, C. Mar-2008 In : European Journal of Immunology. 38, 3, p. 818-828, 11 p.

    Research output: Contribution to journal › Article

  249. What pharmacological resources to use to activate AMPK? AICAR, metformin or A-769662, a new AMPK activator

    Viollet, B., Foretz, M., Leclerc, J., Hardie, G. & Sakarmoto, K. Mar-2008 In : Diabetes & Metabolism. 34, s3, p. H23, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  250. An N-Myc truncation analogous to c-Myc-S induces cell proliferation independently of transactivation but dependent on Myc homology box II

    Cowling, V. H. & Cole, M. D. 21-Feb-2008 In : Oncogene. 27, 9, p. 1327-1332, 6 p.

    Research output: Contribution to journal › Article

  251. Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis

    Hamilton, G., Colbert, J. D., Schuettelkopf, A. W. & Watts, C. 6-Feb-2008 In : EMBO Journal. 27, 3, p. 499-508, 10 p.

    Research output: Contribution to journal › Article

  252. The interplay between viruses and innate immune signaling: recent insights and therapeutic opportunities

    Unterholzner, L. & Bowie, A. G. 1-Feb-2008 In : Biochemical Pharmacology. 75, 3, p. 589-602, 14 p.

    Research output: Contribution to journal › Article

  253. Macular oedema is not predicted by perifoveal single blot haemorrhages

    Schofield, C. J., Ellis, J. D., Ellingford, A., Morris, A. D. & Leese, G. Feb-2008 In : Diabetic Medicine. 25, 2, p. 129-133, 5 p.

    Research output: Contribution to journal › Article

  254. TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages

    Rousseau, S., Papoutsopoulou, M., Symons, A., Cook, D., Lucocq, J. M., Prescott, A. R., Garra, A. O., Ley, S. C. & Cohen, P. 15-Jan-2008 In : Journal of Cell Science. 121, 2, p. 149-154, 6 p.

    Research output: Contribution to journal › Article

  255. 3-phosphoinositide-dependent kinase 1 deficiency perturbs toll-like receptor signaling events and actin cytoskeleton dynamics in dendritic cells

    Zaru, R., Mollahan, P. & Watts, C. 11-Jan-2008 In : Journal of Biological Chemistry. 283, 2, p. 929-939, 11 p.

    Research output: Contribution to journal › Article

  256. Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease

    Hardie, D. G., Tontonoz, P. (ed.) & Nagy, L. (ed.) 9-Jan-2008 In : FEBS Letters. 582, 1, p. 81-89, 9 p.

    Research output: Contribution to journal › Scientific review

  257. Key roles for AMP-activated protein kinase in the function of the carotid body?

    Wyatt, C. N., Pearson, S. A., Kumar, P., Peers, C., Hardie, D. G. & Evans, A. M. 1-Jan-2008 Integration in respiratory control: from genes to systems. Poulin, M. J. & Wilson, R. J. A. (eds.). Springer, p. 63-68 6 p. (Advances in Experimental Medicine and Biology; 2).

    Research output: Chapter in Book/Report/Conference proceeding › Other chapter contribution

  258. Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases

    Martin-Granados, C., Philp, A., Oxenham, S. K., Prescott, A. R. & Cohen, P. T. W. 2008 In : International Journal of Biochemistry & Cell Biology. 40, 10, p. 2315-2332, 18 p.

    Research output: Contribution to journal › Article

  259. Lymphoblasts produce a lysosomal protease that rapidly degrades L-asparaginase-implications for therapy in childhood acute lymphoblastic leukemia

    Patel, N., Krishnan, S., Offman, M. N., Moss, C. X., Ariffin, H., Vandelft, F. W., Yiannikouris, O., Leighton, C., Alexander, S., Holland, M., Khater, D., Liu, J. Z., Essink, M., Bates, P., Watts, C. & Saha, V. 16-Nov-2007 In : Blood. 110, 11, p. 821A-821A, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  260. Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling

    Lackey, J., Barnett, J., Davidson, L., Batty, I. H., Leslie, N. R. & Downes, C. P. Nov-2007 In : Oncogene. 26, 50, p. 7132-7142, 11 p.

    Research output: Contribution to journal › Article

  261. Reorganization of centrosomal marker proteins coincides with epithelial cell differentiation in the vertebrate lens

    Dahm, R., Procter, J. E., Ireland, M. E., Lo, W-K., Mogensen, M. M., Quinlan, R. A. & Prescott, A. R. Nov-2007 In : Experimental Eye Research. 85, 5, p. 696-713, 18 p.

    Research output: Contribution to journal › Article

  262. Reorganization of centrosomal marker proteins coincides with epithelial cell differentiation in the vertebrate lens

    Dahm, R., Procter, J. E., Ireland, M. E., Lo, W-K., Mogensen, M. M., Quinlan, R. A. & Prescott, A. R. Nov-2007 In : Experimental Eye Research. 85, 5, p. 696-713, 18 p.

    Research output: Contribution to journal › Article

  263. The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

    Zaru, R., Ronkina, N., Gaestel, M., Arthur, S. & Watts, C. Nov-2007 In : Nature Immunology. 8, 11, p. 1227-1235, 9 p.

    Research output: Contribution to journal › Article

  264. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR

    Geraghty, K. M., Chen, S., Harthill, J. E., Ibrahim, A. F., Toth, R., Morrice, N. A., Vandermoere, F., Moorhead, G. B., Hardie, D. G. & MacKintosh, C. 15-Oct-2007 In : Biochemical Journal. 407, p. 231-241, 11 p.

    Research output: Contribution to journal › Article

  265. Scottish foot ulcer risk score predicts foot ulcer healing in a regional specialist foot clinic

    Leese, G., Schofield, C., McMurray, B., Libby, G., Golden, J., MacAlpine, R., Cunningham, S., Morris, A., Flett, M. & Griffiths, G. Aug-2007 In : Diabetes Care. 30, 8, p. 2064-2069, 6 p.

    Research output: Contribution to journal › Article

  266. Distinct sensor pathways in the hierarchical control of SNAT2, a putative amino acid transceptor, by amino acid availability

    Hyde, R., Cwiklinski, E. L., MacAulay, K., Taylor, P. M. & Hundal, H. S. 6-Jul-2007 In : Journal of Biological Chemistry. 282, 27, p. 19788-19798, 11 p.

    Research output: Contribution to journal › Article

  267. Tissue uptake of thyroid hormone by amino acid transporters

    Taylor, P. M. & Ritchie, J. W. A. Jun-2007 In : Best Practice & Research Clinical Endocrinology & Metabolism. 21, 2, p. 237-251, 15 p.

    Research output: Contribution to journal › Article

  268. ZnT5 variant B is a bidirectional zinc transporter and mediates zinc uptake in human intestinal Caco-2 cells

    Valentine, R. A., Jackson, K. A., Christie, G. R., Mathers, J. C., Taylor, P. M. & Ford, D. 11-May-2007 In : Journal of Biological Chemistry. 282, 19, p. 14389-14393, 5 p.

    Research output: Contribution to journal › Article

  269. PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration

    Leslie, N. R., Yang, X., Downes, C. P. & Weijer, C. J. Jan-2007 In : Current Biology. 17, 2, p. 115-125, 11 p.

    Research output: Contribution to journal › Article

  270. 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men

    Cuthbertson, D. J., Babraj, J. A., Mustard, K. J. W., Towler, M. C., Green, K. A., Wackerhage, H., Leese, G. P., Baar, K., Thomason-Hughes, M., Sutherland, C., Hardie, D. G. & Rennie, M. J. 2007 In : Diabetes. 56, 8, p. 2078-2084, 7 p.

    Research output: Contribution to journal › Article

  271. Age-related HMG-CoA reductase deregulation depends on ROS-induced p38 activation

    Pallottini, V., Martini, C., Cavallini, G., Bergamini, E., Mustard, K. J., Hardie, D. G. & Trentalance, A. 2007 In : Mechanisms of Ageing and Development. 128, 11-12, p. 688-695, 8 p.

    Research output: Contribution to journal › Article

  272. c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1

    Cowling, V. H., D'Cruz, C. M., Chodosh, L. A. & Cole, M. D. 2007 In : Molecular and Cellular Biology. 27, 14, p. 5135-5146, 12 p.

    Research output: Contribution to journal › Article

  273. How I became a biochemist

    Hardie, D. G. 2007 In : IUBMB Life. 59, 12, p. 793-796, 4 p.

    Research output: Contribution to journal › Article

  274. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase

    Goransson, O., McBride, A., Hawley, S. A., Ross, F. A., Shpiro, N., Foretz, M., Viollet, B., Hardie, D. G. & Sakamoto, K. 2007 In : Journal of Biological Chemistry. 282, 45, p. 32549-32560, 12 p.

    Research output: Contribution to journal › Article

  275. The Myc transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding

    Cowling, V. H. & Cole, M. D. 2007 In : Molecular and Cellular Biology. 27, 6, p. 2059-2073, 15 p.

    Research output: Contribution to journal › Article

  276. The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation

    Zhang, Y., Lucocq, J. M., Yamamoto, M. & Hayes, J. D. 2007 In : Biochemical Journal. 408, 2, p. 161-172, 12 p.

    Research output: Contribution to journal › Article

  277. Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression

    Lindsay, Y., McCoull, D., Davidson, L., Leslie, N. R., Fairservice, A., Gray, A., Lucocq, J. & Downes, C. P. Dec-2006 In : Journal of Cell Science. 119, 24, p. 5160-5168, 9 p.

    Research output: Contribution to journal › Article

  278. A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression

    Finlay, D., Ruiz-Alcaraz, A. J., Lipina, C., Perrier, S. & Sutherland, C. Oct-2006 In : Journal of Molecular Endocrinology. 37, 2, p. 227-237, 11 p.

    Research output: Contribution to journal › Article

  279. Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue

    Baird, F. E., Pinilla-Tenas, J. J., Ogilvie, W. L. J., Ganapathy, V., Hundal, H. S. & Taylor, P. M. 15-Jul-2006 In : Biochemical Journal. 397, 2, p. 369-375, 7 p.

    Research output: Contribution to journal › Article

  280. Structural basis of reduction-dependent activation of human cystatin F

    Schüttelkopf, A. W., Hamilton, G., Watts, C. & van Aalten, D. M. F. 16-Jun-2006 In : Journal of Biological Chemistry. 281, 24, p. 16570-16575, 6 p.

    Research output: Contribution to journal › Article

  281. A conserved Myc protein domain, MBIV, regulates DNA binding, apoptosis, transformation, and G2 arrest

    Cowling, V. H., Chandriani, S., Whitfield, M. L. & Cole, M. D. Jun-2006 In : Molecular and Cellular Biology. 26, 11, p. 4226-4239, 14 p.

    Research output: Contribution to journal › Article

  282. A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic β-cells

    Ning, K., Miller, L. C., Laidlaw, H. A., Burgess, L. A., Perera, N. M., Downes, C. P., Leslie, N. R. & Ashford, M. L. J. Jun-2006 In : The EMBO Journal. 25, 11, p. 2377-2387, 11 p.

    Research output: Contribution to journal › Article

  283. Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226

    Liu, H. K., Perrier, S., Lipina, C., Finlay, D., McLauchlan, H., Hastie, C. J., Hundal, H. S., Sutherland, C. & Sutherland, C. 6-Apr-2006 In : BMC Molecular Biology. 7, p. -, 12 p., 14

    Research output: Contribution to journal › Article

  284. The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

    Jaleel, M., Villa, F., Deak, M., Toth, R., Prescott, A. R., van Aalten, D. M. F. & Alessi, D. R. 15-Mar-2006 In : Biochemical Journal. 394, 3, p. 545-555, 11 p.

    Research output: Contribution to journal › Article

  285. Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha

    Sakamoto, K., Zarrinpashneh, E., Budas, G., Pouleur, A-C., Dutta, A., Prescott, A. R., Vanoverschelde, J-L., Ashworth, A., Jovanovic, A., Alessi, D. & Bertrand, L. 2006 In : American Journal of Physiology, Endocrinology and Metabolism. 290, 5, p. E780-E788

    Research output: Contribution to journal › Article

  286. Developmental changes in electrophysiological properties and synaptic transmission in rat intracardiac ganglion neurons

    Rimmer, K. & Harper, A. A. 2006 In : Journal of Neurophysiology. 95, 6, p. 3543-3552, 10 p.

    Research output: Contribution to journal › Article

  287. Diacylglycerol and protein kinase D localization during T lymphocyte activation

    Spitaler, M., Emslie, E., Wood, C. D. & Cantrell, D. 2006 In : Immunity. 24, 5, p. 535-546, 12 p.

    Research output: Contribution to journal › Article

  288. A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration

    Ruiz-Alcaraz, A. J., Liu, H-K., Cuthbertson, D. J., McManus, E. J., Akhtar, S., Lipina, C., Morris, A. D., Petrie, J. R., Hundal, H. S. & Sutherland, C. 1-Dec-2005 In : Biochemical Journal. 392, p. 345-352, 8 p.

    Research output: Contribution to journal › Article

  289. Generation and characterization of p38beta (MAPK11) gene-targeted mice

    Beardmore, V. A., Hinton, H. J., Eftychi, C., Apostolaki, M., Armaka, M., Darragh, J., McIlrath, J., Carr, J. M., Armit, L. J., Clacher, C., Malone, L., Kollias, G. & Arthur, S. C. Dec-2005 In : Molecular and Cellular Biology. 25, 23, p. 10454-10464, 11 p.

    Research output: Contribution to journal › Article

  290. Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle

    Turban, S., Beardmore, V. A., Carr, J. M., Sakamoto, K., Hajduch, E., Arthur, J. S. C. & Hundal, H. S. Nov-2005 In : Diabetes. 54, 11, p. 3161-3168, 8 p.

    Research output: Contribution to journal › Article

  291. Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice

    Bayascas, J. R., Leslie, N., Parsons, R., Fleming, S. & Alessi, D. Oct-2005 In : Current Biology. 15, 20, p. 1839-1846, 8 p.

    Research output: Contribution to journal › Article

  292. Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

    Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G. & Hardie, D. G. Jul-2005 In : Cell Metabolism. 2, 1, p. 9-19, 11 p.

    Research output: Contribution to journal › Article

  293. The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number

    Roper, J. R., Guther, M. L. S., MacRae, J. I., Prescott, A. R., Hallyburton, I., Acosta-Serrano, A. & Ferguson, M. A. J. 20-May-2005 In : Journal of Biological Chemistry. 280, 20, p. 19728-19736, 9 p.

    Research output: Contribution to journal › Article

  294. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

    Sakamoto, K., McCarthy, A., Smith, D., Green, K. A., Hardie, D. G., Ashworth, A. & Alessi, D. R. May-2005 In : The EMBO Journal. 24, 10, p. 1810-1820, 11 p.

    Research output: Contribution to journal › Article

  295. Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells

    MacAulay, K., Blair, A. S., Hajduch, E., Terashima, T., Baba, O., Sutherland, C. & Hundal, H. S. 11-Mar-2005 In : Journal of Biological Chemistry. 280, 10, p. 9509-9518, 10 p.

    Research output: Contribution to journal › Article

  296. Ceramide down-regulates System A amino acid transport and protein synthesis in rat skeletal muscle cells

    Hyde, R., Hajduch, E., Powell, D. J., Taylor, P. M. & Hundal, H. S. Mar-2005 In : FASEB Journal. 19, 3, p. 461-463, 3 p.

    Research output: Contribution to journal › Article

  297. SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway

    Fukuhara, N., Ebert, J., Unterholzner, L., Lindner, D., Izaurralde, E. & Conti, E. 18-Feb-2005 In : Molecular Cell. 17, 4, p. 537-47, 11 p.

    Research output: Contribution to journal › Article

  298. Trypanosoma brucei glycoproteins contain novel giant poly-N-acetyllactosamine carbohydrate chains

    Atrih, A., Richardson, J. M., Prescott, A. R. & Ferguson, M. A. J. 14-Jan-2005 In : Journal of Biological Chemistry. 280, 2, p. 865-871, 7 p.

    Research output: Contribution to journal › Article

  299. AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

    Rencurel, F., Stenhouse, A., Hawley, S. A., Friedberg, T., Hardie, D. G., Sutherland, C. & Wolf, C. R. 2005 In : Journal of Biological Chemistry. 280, 6, p. 4367-4373, 7 p.

    Research output: Contribution to journal › Article

  300. Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3

    Lipina, C., Huang, X., Finlay, D., McManus, E. J., Alessi, D. R. & Sutherland, C. 2005 In : Biochemical Journal. 392, 3, p. 633-639, 7 p.

    Research output: Contribution to journal › Article

  301. Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

    Mora, A., Lipina, C., Tronche, F., Sutherland, C. & Alessi, D. R. 2005 In : Biochemical Journal. 385, 3, p. 639-648, 10 p.

    Research output: Contribution to journal › Article

  302. Developmental changes in expression of GABAA receptor-channels in rat intrinsic cardiac ganglion neurones

    Fischer, H., Harper, A. A., Anderson, C. R. & Adams, D. J. 2005 In : Journal of Physiology. 564, 2, p. 465-474, 10 p.

    Research output: Contribution to journal › Article

  303. Molecular mechanisms of kinetochore capture by spindle microtubules

    Tanaka, K., Mukae, N., Dewar, H., Breugel, M. ., James, E. K., Prescott, A. R., Antony, C. & Tanaka, T. U. 2005 In : Nature. 434, 7036, p. 987-994, 8 p.

    Research output: Contribution to journal › Article

  304. Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and K-ATP channel activation

    Mirshamsi, S., Laidlaw, H. A., Ning, K., Anderson, E., Burgess, L. A., Gray, A., Sutherland, C. & Ashford, M. L. J. 6-Dec-2004 In : BMC Neuroscience. 5, p. -, 18 p., 54

    Research output: Contribution to journal › Article

  305. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle

    Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M. & Rennie, M. J. Dec-2004 In : FASEB Journal. 18, 15, p. 422- 424, 3 p.

    Research output: Contribution to journal › Article

  306. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay

    Unterholzner, L. & Izaurralde, E. 19-Nov-2004 In : Molecular Cell. 16, 4, p. 587-96, 10 p.

    Research output: Contribution to journal › Article

  307. Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element

    Finlay, D., Patel, S., Dickson, L. M., Shpiro, N., Marquez, R., Rhodes, C. J. & Sutherland, C. 6-Sep-2004 In : BMC Molecular Biology. 5, p. -, 13 p., 15

    Research output: Contribution to journal › Article

  308. Bidirectional substrate fluxes through the System N (SNAT5) glutamine transporter may determine net glutamine flux in rat liver

    Baird, F. E., Beattie, K. J., Hyde, A. R., Ganapathy, V., Rennie, M. J. & Taylor, P. M. 1-Sep-2004 In : Journal of Physiology. 559, 2, p. 367-381, 15 p.

    Research output: Contribution to journal › Article

  309. Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR

    Sakamoto, K., Goransson, O., Hardie, D. G. & Alessi, D. R. Aug-2004 In : American Journal of Physiology, Endocrinology and Metabolism. 287, 2, p. E310-E317

    Research output: Contribution to journal › Article

  310. Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex

    Bono, F., Ebert, J., Unterholzner, L., Güttler, T., Izaurralde, E. & Conti, E. Mar-2004 In : EMBO Reports. 5, 3, p. 304-10, 7 p.

    Research output: Contribution to journal › Article

  311. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

    Lizcano, J. M., Goransson, O., Toth, R., Deak, M., Morrice, N. A., Boudeau, J., Hawley, S., Udd, L., Makela, T. P., Hardie, D. G. & Alessi, D. R. Feb-2004 In : The EMBO Journal. 23, 4, p. 833-843, 11 p.

    Research output: Contribution to journal › Article

  312. CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

    Scott, J. W., Hawley, S. A., Green, K. A., Anis, M., Stewart, G., Scullion, G. A., Norman, D. G. & Hardie, D. G. 2004 In : Journal of Clinical Investigation. 113, 2, p. 274-284, 11 p.

    Research output: Contribution to journal › Article

  313. Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling

    West, M., Wallin, R. P. A., Matthews, S., Svensson, H. G., Zaru, R., Ljunggren, H-G., Prescott, A. R. & Watts, C. 2004 In : Science. 305, 5687, p. 1153-1157, 5 p.

    Research output: Contribution to journal › Article

  314. H+/amino acid transporter 1 (PAT1) is the imino acid carrier: an intestinal nutrient/drug transporter in human and rat

    Anderson, C. M. H., Grenade, D. S., Boll, M., Foltz, M., Wake, K. A., Kennedy, D. J., Munck, L. K., Miyauchi, S., Taylor, P. M., Campbell, F. C., Munck, B. G., Daniel, H., Ganapathy, V. & Thwaites, D. T. 2004 In : Gastroenterology. 127, 5, p. 1410-1422, 13 p.

    Research output: Contribution to journal › Article

  315. p14 arf promotes small ubiquitin-like modifier conjugation of Werners helicase

    Woods, Y. L., Xirodimas, D. P., Prescott, A. R., Sparks, A., Lane, D. P. & Saville, M. K. 2004 In : Journal of Biological Chemistry. 279, 48, p. 50157-50166, 10 p.

    Research output: Contribution to journal › Article

  316. Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo

    Thompson, A. M. & 23 others Spruce, B. A., Campbell, L. A., McTavish, N., Cooper, M. A., Appleyard, M. V. L., O'Neill, M., Howie, J., Samson, J., Watt, S., Murray, K., McLean, D., Leslie, N. R., Safrany, S. T., Ferguson, M. J., Peters, J. A., Prescott, A. R., Box, G., Hayes, A., Nutley, B., Raynaud, F., Downes, C. P., Lambert, J. J. & Eccles, S. 2004 In : Cancer Research. 64, 1, p. 4875-4886, 12 p.

    Research output: Contribution to journal › Article

  317. Deletion of the GPIdeAc gene alters the location and fate of glycosylphosphatidylinositol precursors in Trypanosoma brucei

    Guther, M. L. S., Prescott, A. R. & Ferguson, M. A. J. 16-Dec-2003 In : Biochemistry. 42, 49, p. 14532-14540, 9 p.

    Research output: Contribution to journal › Article

  318. Redox regulation of PI 3-kinase signalling via inactivation of PTEN

    Leslie, N., Bennett, D., Downes, P., Gray, A., Lindsay, Y. E. & Stewart, H. Oct-2003 In : EMBO Journal. 22, 20, p. 5501-5510, 10 p.

    Research output: Contribution to journal › Article

  319. Complexes between the LKB1 tumor suppressor, STRAD α/β and MO25 α/β are upstream kinases in the AMP-activated protein kinase cascade

    Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Makela, T. P., Alessi, D. R. & Hardie, D. G. Sep-2003 In : Journal of Biology. 2, 4, p. 28, 1 p.

    Research output: Contribution to journal › Article

  320. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

    Mora, A., Davies, A. M., Bertrand, L., Sharif, I., Budas, G. R., Jovanovic, S., Mouton, V., Kahn, C. R., Lucocq, J. M., Gray, G. A., Jovanovic, A. & Alessi, D. R. Sep-2003 In : The EMBO Journal. 22, 18, p. 4666-4676, 11 p.

    Research output: Contribution to journal › Article

  321. Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex

    Sutherland, C. M., Hawley, S. A., McCartney, R. R., Leech, A., Stark, M. J. R., Schmidt, M. C. & Hardie, D. G. 5-Aug-2003 In : Current Biology. 13, 15, p. 1299-1305, 7 p.

    Research output: Contribution to journal › Article

  322. Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways

    Gatfield, D., Unterholzner, L., Ciccarelli, F. D., Bork, P. & Izaurralde, E. 1-Aug-2003 In : EMBO Journal. 22, 15, p. 3960-70, 11 p.

    Research output: Contribution to journal › Article

  323. Nuclear speckle localisation of the small heat shock protein αB-crystallin and its inhibition by the R120G cardiomyopathy-linked mutation

    Van Den Ijssel, P., Wheelock, R., Prescott, A., Russell, P. & Quinlan, R. A. Jul-2003 In : Experimental Cell Research. 287, 2, p. 249-261, 13 p.

    Research output: Contribution to journal › Article

  324. Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

    Beugnet, A., Tee, A. R., Taylor, P. M. & Proud, C. G. 1-Jun-2003 In : Biochemical Journal. 372, 2, p. 555-566, 12 p.

    Research output: Contribution to journal › Article

  325. Knockout of the intermediate filament protein CP49 destabilises the lens fibre cell cytoskeleton and decreases lens optical quality, but does not induce cataract

    Sandilands, A., Prescott, A. R., Wegener, A., Zoltoski, R. K., Hutcheson, A. M., Masaki, S., Kuszak, J. R. & Quinlan, R. A. Mar-2003 In : Experimental Eye Research. 76, 3, p. 385-391, 7 p.

    Research output: Contribution to journal › Article

  326. Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts

    Gray, A., Olsson, H., Batty, I., Priganica, L. & Downes, P. Feb-2003 In : Analytical Biochemistry. 313, 2, p. 234-245, 12 p.

    Research output: Contribution to journal › Article

  327. A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias

    Hudson, E. R., Pan, D. A., James, J., Lucocq, J. M., Hawley, S. A., Green, K. A., Baba, O., Terashima, T. & Hardie, D. G. 2003 In : Current Biology. 13, 10, p. 861-866, 6 p.

    Research output: Contribution to journal › Article

  328. A role for thyroid hormone transporters in transcriptional regulation by thyroid hormone receptors

    Ritchie, J. W. A., Shi, Y. -B., Hayashi, Y., Baird, F. E., Muchekehu, R. W., Christie, G. R. & Taylor, P. M. 2003 In : Molecular Endocrinology. 17, 4, p. 653-661, 9 p.

    Research output: Contribution to journal › Article

  329. Amino acid transporters: roles in amino acid sensing and signalling in animal cells

    Hyde, R., Taylor, P. M. & Hundal, H. S. 2003 In : Biochemical Journal. 373, 1, p. 1-18, 18 p.

    Research output: Contribution to journal › Article

  330. Asparagine endopeptidase can initiate the removal of the MHC class II invariant chain chaperone

    Manoury, B., Mazzeo, D., Li, D. N., Billson, J., Loak, K., Benaroch, P. & Watts, C. 2003 In : Immunity. 18, 4, p. 489-498, 10 p.

    Research output: Contribution to journal › Article

  331. Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism

    Powell, D. J., Hajduch, E., Kular, G. & Hundal, H. S. H. 2003 In : Molecular and Cellular Biology. 23, 21, p. 7794-7808, 15 p.

    Research output: Contribution to journal › Article

  332. Different mechanisms are used by insulin to repress three genes that contain a homologous thymine-rich insulin response element

    Patel, S., Lipina, C. & Sutherland, C. 2003 In : FEBS Letters. 549, 1-3, p. 72-76, 5 p.

    Research output: Contribution to journal › Article

  333. Loss of Kindlin-1, a human homolog of the Caenorhabditis elegans actin–extracellular-matrix linker protein UNC-112, causes Kindler syndrome

    Siegel, D. H. , Ashton, G. H. S. , Penagos, H. G. , Lee, J. V. , Feiler, H. S. , Wilhelmsen, K. C. , South, A. P. , Smith, F. , Prescott, A. R. , Wessagowit, V. , Oyama, N. , Akiyama, M. , Al Aboud, D. , Al Aboud, K. , Al Githami, A. , Al Hawsawi, K. , Al Ismaily, A. , Al-Suwaid, R. , Atherton, D. J. , Caputo, R. & 22 others Fine, J-D., Frieden, I. J., Fuchs, E., Haber, R. M., Harada, T., Kitajima, Y., Mallory, S. B., Ogawa, H., Sahin, S., Shimizu, H., Suga, Y., Tadini, G., Tsuchiya, K., Wiebe, C. B., Wojnarowska, F., Zaghloul, A. B., Hamada, T., Mallipeddi, R., Eady, R. A. J., McLean, I., McGrath, J. A. & Epstein, E. H. 2003 In : American Journal of Human Genetics. 73, 1, p. 174-187, 14 p.

    Research output: Contribution to journal › Article

  334. Mitochondrial remnant organelles of Giardia function in iron-sulphur protein maturation

    Tovar, J., Leon-Avila, G., Sanchez, L. B., Sutak, R., Tachezy, J., van der Giezen, M., Hernandez, M., Muller, M. & Lucocq, J. M. 2003 In : Nature. 426, 6963, p. 172-176, 5 p.

    Research output: Contribution to journal › Article

  335. Observation of keratin particles showing fast bidirectional movement colocalized with microtubules

    Liovic, M., Mogensen, M. M., Prescott, A. R. & Lane, E. B. 2003 In : Journal of Cell Science. 116, 8, p. 1417-1427, 11 p.

    Research output: Contribution to journal › Article

  336. Regulation of L-leucine transport in rat kidney by dexamethasone and triiodothyronine

    Schwertfeger, M., Pissowotzki, K., Fleck, C. & Taylor, P. M. 2003 In : Amino Acids. 25, 1, p. 75-83, 9 p.

    Research output: Contribution to journal › Article

  337. Regulation of renal amino acid (AA) transport by hormones, drugs and xenobiotics - a review

    Fleck, C., Schwertfeger, M. & Taylor, P. M. 2003 In : Amino Acids. 24, 4, p. 347-374, 28 p.

    Research output: Contribution to journal › Article

  338. Altered aggregation properties of mutant γ-crystallins cause inherited cataract

    Sandilands, A., Hutcheson, A. M., Long, H. A., Prescott, A. R., Vrensen, G., Loster, J., Klopp, N., Lutz, R. B., Graw, J., Masaki, S., Dobson, C. M., MacPhee, C. E. & Quinlan, R. A. Nov-2002 In : The EMBO Journal. 21, 22, p. 6005-6014, 10 p.

    Research output: Contribution to journal › Article

  339. Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain

    Cowling, V., Downward, J. & Martin, S. J. (ed.) Oct-2002 In : Cell Death & Differentiation. 9, 10, p. 1046-1056, 11 p.

    Research output: Contribution to journal › Article

  340. A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane

    Cragg, R. A., Christie, G. R., Phillips, S. R., Russi, R. M., Kury, S., Mathers, J. C., Taylor, P. M. & Ford, D. 21-Jun-2002 In : Journal of Biological Chemistry. 277, 25, p. 22789-22797, 9 p.

    Research output: Contribution to journal › Article

  341. Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner

    Christie, G. R., Hajduch, E., Hundal, H. S., Proud, C. G. & Taylor, P. M. 22-Mar-2002 In : Journal of Biological Chemistry. 277, 12, p. 9952-9957, 6 p.

    Research output: Contribution to journal › Article

  342. Muscarinic receptors mediate phospholipase C-dependent activation of protein kinase B via Ca2+, ErbB3, and phosphoinositide 3-Kinase in 1321N1 astrocytoma cells

    Tang, X., Batty, I. H. & Downes, C. P. Jan-2002 In : Journal of Biological Chemistry. 277, 1, p. 338-344, 7 p.

    Research output: Contribution to journal › Article

  343. Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1

    Watt, S. A., Kular, G., Fleming, I. N., Downes, C. P. & Lucocq, J. M. Jan-2002 In : Biochemical Journal. 363, 3, p. 657-666, 10 p.

    Research output: Contribution to journal › Article

  344. Complex regulation of thyroid hormone action: multiple opportunities for pharmacological intervention

    Shi, Y-B., Ritchie, J. W. A. & Taylor, P. M. 2002 In : Pharmacology & Therapeutics. 94, 3, p. 235-251, 17 p.

    Research output: Contribution to journal › Scientific review

  345. Delivery of thyroid hormone from plasma membrane to nucleus: a role for the cytoskeleton and/or vesicular trafficking?

    Muchekehu, R. W. & Taylor, P. M. 2002 In : Journal of Physiology. 544, p. 117P-117P, 1 p., S029

    Research output: Contribution to journal › Meeting abstract

  346. Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP

    Manoury, B., Mazzeo, D., Fugger, L., Viner, N., Ponsford, M., Streeter, H., Mazza, G., Wraith, D. C. & Watts, C. 2002 In : Nature Immunology. 3, 2, p. 169-174, 6 p.

    Research output: Contribution to journal › Article

  347. Inhibition of autophagy in mitotic animal cells

    Eskelinen, E-L., Prescott, A. R., Cooper, J., Brachmann, S. M., Wang, L., Tang, X., Backer, J. M. & Lucocq, J. M. 2002 In : Traffic. 3, 12, p. 878-893, 16 p.

    Research output: Contribution to journal › Article

  348. The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells

    Mogensen, M. M., Tucker, J. B., Mackie, J. B., Prescott, A. R. & Nathke, I. S. 2002 In : Journal of Cell Biology. 157, 6, p. 1041-1048, 8 p.

    Research output: Contribution to journal › Article

  349. Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

    Rena, G., Woods, Y. L., Prescott, A. R., Peggie, M., Unterman, T. G., Williams, M. R. & Cohen, P. 2002 In : The EMBO Journal. 21, 9, p. 2263-2271, 9 p.

    Research output: Contribution to journal › Article

  350. Role of the System L permease LAT1 in amino acid and iodothyronine transport in placenta

    Ritchie, J. W. A. & Taylor, P. M. 15-Jun-2001 In : Biochemical Journal. 356, 3, p. 719-725, 7 p.

    Research output: Contribution to journal › Article

  351. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent protein kinase, but not its farnesylation at Cys433, is essential for LKB1 to suppress cell growth

    Sapkota, G. P., Kieloch, A., Lizcano, J. M., Lain, S., Arthur, J. . S. C., Williams, M. R., Morrice, N., Deak, M. & Alessi, D. R. 1-Jun-2001 In : Journal of Biological Chemistry. 276, 22, p. 19469-19482, 14 p.

    Research output: Contribution to journal › Article

  352. Evidence for prebudding arrest of ER export in animal cell mitosis and its role in generating Golgi partitioning intermediates

    Prescott, A. R., Farmaki, T., Thomson, C., James, J., Paccaud, J-P., Tang, B-L., Hong, W., Quinn, M., Ponnambalam, S. & Lucocq, J. May-2001 In : Traffic. 2, 5, p. 321-335, 15 p.

    Research output: Contribution to journal › Article

  353. An essential role for calmodulin in regulating human T cell aggregation

    Fagerholm, S. C., Prescott, A., Cohen, P., Gahmberg, C. G. & Lehto, V-P. (ed.) 28-Feb-2001 In : FEBS Letters. 491, 1-2, p. 131-6, 6 p.

    Research output: Contribution to journal › Article

  354. Verapamil block of large-conductance Ca-activated K channels in rat aortic myocytes

    Harper, A. A., Catacuzzeno, L., Trequattrini, C., Petris, A. & Franciolini, F. Jan-2001 In : Journal of Membrane Biology. 179, 2, p. 103-111, 9 p.

    Research output: Contribution to journal › Article

  355. Developmental changes in hyperpolarization-activated currents I(h) and I(K(IR)) in isolated rat intracardiac neurons

    Hogg, R. C., Harper, A. A. & Adams, D. J. 2001 In : Journal of Neurophysiology. 86, 1, p. 312-320, 9 p.

    Research output: Contribution to journal › Article

  356. Effect of hypothyroidism on pathways for iodothyronine and tryptophan uptake into rat adipocytes

    Ritchie, J. W. A., Collingwood, C. J. F. & Taylor, P. M. 2001 In : American Journal of Physiology, Endocrinology and Metabolism. 280, 2, p. E254-E259, 6 p.

    Research output: Contribution to journal › Article

  357. Mechanisms of glutamine transport in rat adipocytes and acute regulation by cell swelling

    Ritchie, J. W. A., Baird, F. E., Christie, G. R., Stewart, A., Low, S. Y., Hundal, H. S. & Taylor, P. M. 2001 In : Cellular Physiology and Biochemistry. 11, 5, p. 259-270, 12 p.

    Research output: Contribution to journal › Article

  358. Neutral amino acid transport via system L at the basolateral membrane of human intestinal Caco-2 cell monolayers

    McCloy, L. R. R., Taylor, P. M. & Thwaites, D. T. 2001 In : Journal of Physiology. 535, p. 48P-49P, 2 p., S036

    Research output: Contribution to journal › Meeting abstract

  359. Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

    Rena, G., Prescott, A. R., Guo, S., Cohen, P. & Unterman, T. G. 2001 In : Biochemical Journal. 354, 3, p. 605-612, 8 p.

    Research output: Contribution to journal › Article

  360. The trigger to cell death determines the efficiency with which dying cells are cleared by neighbours

    Wiegand, U. K., Corbach, S., Prescott, A. R., Savill, J. & Spruce, B. A. 2001 In : Cell Death & Differentiation. 8, 7, p. 734-746, 13 p.

    Research output: Contribution to journal › Article

  361. TPIP: a novel phosphoinositide 3-phosphatase

    Walker, S., Downes, P. & Leslie, N. 2001 In : Biochemical Journal. 360, 2, p. 277-283, 7 p.

    Research output: Contribution to journal › Article

  362. 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase

    Lochhead, P. A., Salt, I. P., Walker, K. S., Hardie, D. G. & Sutherland, C. 2000 In : Diabetes. 49, 6, p. 896-903, 8 p.

    Research output: Contribution to journal › Article

  363. Transformation of monomorphic Trypanosoma brucei bloodstream form trypomastigotes into procyclic forms at 37 degrees C by removing glucose from the culture medium

    Milne, K. G., Prescott, A. R. & Ferguson, M. A. J. 1-Jul-1998 In : Molecular and Biochemical Parasitology. 94, 1, p. 99-112, 14 p.

    Research output: Contribution to journal › Article

  364. The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?

    Hardie, D. G., Carling, D. & Carlson, M. Jul-1998 In : Annual Review of Biochemistry. 67, p. 821-855, 35 p.

    Research output: Contribution to journal › Scientific review

  365. Structural characterisation of two forms of procyclic acidic repetitive protein expressed by procyclic forms of Trypanosoma brucei

    Treumann, A., Zitzmann, N., Hulsmeier, A., Prescott, A. R., Almond, A., Sheehan, J. & Ferguson, M. A. J. 20-Jun-1997 In : Journal of Molecular Biology. 269, 4, p. 529-547, 19 p.

    Research output: Contribution to journal › Article

  366. The prohibitin family of mitochondrial proteins regulate replicative lifespan

    Coates, P. J., Jamieson, D. J., Smart, K., Prescott, A. R. & Hall, P. A. 1997 In : Current Biology. 7, 8, p. 607-610, 4 p.

    Research output: Contribution to journal › Article

  367. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

    Hawley, S. A., Davison, M., Woods, A., Davies, S. P., Beri, R. K., Carling, D. & Hardie, D. G. 1-Nov-1996 In : Journal of Biological Chemistry. 271, 44, p. 27879-27887, 9 p.

    Research output: Contribution to journal › Article

  368. Mutations which block the binding of calmodulin to Spc110p cause multiple mitotic defects

    Stirling, D. A., Rayner, T. F., Prescott, A. R. & Stark, M. J. R. 1996 In : Journal of Cell Science. 109, p. 1297-1310, 14 p.

    Research output: Contribution to journal › Article

  369. Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1

    Kearsey, J. M., Coates, P. J., Prescott, A. R., Warbrick, E. & Hall, P. A. 1995 In : Oncogene. 11, 9, p. 1675-1683, 9 p.

    Research output: Contribution to journal › Article

  370. The CL100 gene, which encodes a dual specificity (Tyr/Thr) MAP kinase phosphatase, is highly conserved and maps to human chromosome 5q34

    Emslie, E. A., Jones, T. A., Sheer, D. & Keyse, S. M. 1994 In : Human Genetics. 93, 5, p. 513-6, 4 p.

    Research output: Contribution to journal › Article

  371. Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

    Keyse, S. M. & Emslie, E. A. 1992 In : Nature. 359, 6396, p. 644-7, 4 p.

    Research output: Contribution to journal › Article

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