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  1. AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

    Hardie, D. G. Apr 2015 In : Current Opinion in Cell Biology. 33, April, p. 1-7 7 p.

    Research output: Contribution to journalArticle

  2. Carnosic acid stimulates glucose uptake in skeletal muscle cells via a PME-1/PP2A/PKB signalling axis

    Lipina, C. & Hundal, H. S. Nov 2014 In : Cellular Signalling. 26, 11, p. 2343-2349 6 p.

    Research output: Contribution to journalArticle

  3. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

    Bago, R., Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G. & Alessi, D. R. Nov 2014 In : Biochemical Journal. 463, 3, p. 413-427 15 p.

    Research output: Contribution to journalArticle

  4. Valuation of hospital bed-days released by infection control programs: a comparison of methods

    Stewardson, A. J., Harbarth, S., Graves, N. & TIMBER Study Group Oct 2014 In : Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America. 35, 10, p. 1294-1297 4 p.

    Research output: Contribution to journalArticle

  5. Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells

    Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A. 2 Sep 2014 In : PLoS ONE. 9, 9, 7 p.e106710

    Research output: Contribution to journalArticle

  6. Cystatin F regulates proteinase activity in IL-2-activated natural killer cells

    Maher, K., Konjar, S., Watts, C., Turk, B. & Kopitar-Jerala, N. 1 Sep 2014 In : Protein and Peptide Letters. 21, 9, p. 957-965 9 p.

    Research output: Contribution to journalArticle

  7. Peripheral prion disease pathogenesis is unaltered in the absence of sialoadhesin (Siglec-1/CD169)

    Bradford, B. M., Crocker, P. R. & Mabbott, N. A. 1 Sep 2014 In : Immunology. 143, 1, p. 120-129 10 p.

    Research output: Contribution to journalArticle

  8. Introduction to special issue: 'emerging roles of siglecs in health and disease'

    Crocker, P. R. & Kannagi, R. Sep 2014 In : Glycobiology. 24, 9, p. 784-784 1 p.

    Research output: Contribution to journalArticle

  9. Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus

    Chang, Y-C., Olson, J., Louie, A., Crocker, P. R., Varki, A. & Nizet, V. Sep 2014 In : Journal of Molecular Medicine. 92, 9, p. 951-959 9 p.

    Research output: Contribution to journalArticle

  10. Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung

    McMillan, S. J., Sharma, R. S., Richards, H. E., Hegde, V. & Crocker, P. R. 18 Jul 2014 In : Journal of Biological Chemistry. 289, 29, p. 20370-20376 7 p.

    Research output: Contribution to journalArticle

  11. Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system?

    Lipina, C., Irving, A. J. & Hundal, H. S. 1 Jul 2014 In : American Journal of Physiology, Endocrinology and Metabolism. 307, 1, p. E1-E13

    Research output: Contribution to journalArticle

  12. PDK1 controls upstream PI3K expression and PIP3 generation

    Dieterle, A. M., Böhler, P., Keppeler, H., Alers, S., Berleth, N., Drießen, S., Hieke, N., Pietkiewicz, S., Löffler, A. S., Peter, C., Gray, A., Leslie, N. R., Shinohara, H., Kurosaki, T., Engelke, M., Wienands, J., Bonin, M., Wesselborg, S. & Stork, B. 5 Jun 2014 In : Oncogene. 33, 23, p. 3043-3053 11 p.

    Research output: Contribution to journalArticle

  13. Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies

    Pearce, O. M. T., Läubli, H., Verhagen, A., Secrest, P., Zhang, J., Varki, N. M., Crocker, P. R., Bui, J. D. & Varki, A. 22 Apr 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 16, p. 5998-6003 6 p.

    Research output: Contribution to journalArticle

  14. Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

    Hawley, S. A., Ross, F. A., Gowans, G. J., Tibarewal, P., Leslie, N. R. & Hardie, D. G. 15 Apr 2014 In : Biochemical Journal. 459, 2, p. 275-287 13 p.

    Research output: Contribution to journalArticle

  15. A new protein kinase cascade

    Hardie, D. G. Apr 2014 In : Nature Reviews Molecular Cell Biology. 15, 4, p. 223 1 p.

    Research output: Contribution to journalArticle

  16. Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors

    Liu, R., Iadevaia, V., Averous, J., Taylor, P. M., Zhang, Z. & Proud, C. G. Apr 2014 In : Nucleic Acids Research. 42, 8, p. 5083-5096 14 p.

    Research output: Contribution to journalArticle

  17. A H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation

    Sabbattini, P., Sjoberg, M., Nikic, S., Frangini, A., Holmqvist, P-H., Kunowska, N., Carroll, T., Brookes, E., Arthur, S. J., Pombo, A. & Dillon, N. 15 Mar 2014 In : Molecular Biology of the Cell. 25, 6, p. 904-915 12 p.

    Research output: Contribution to journalArticle

  18. AMPK: regulating energy balance at the cellular and whole body levels

    Hardie, D. G. & Ashford, M. L. J. Mar 2014 In : Physiology. 29, 2, p. 99-107 9 p.

    Research output: Contribution to journalArticle

  19. Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A

    Nardi, F., Lipina, C., Magill, D., Hage Hassan, R., Hajduch, E., Gray, A. & Hundal, H. S. Mar 2014 In : PLoS ONE. 9, 3, 10 p.e92255

    Research output: Contribution to journalArticle

  20. Transcriptionally correlated subcellular dynamics of MBNL1 during lens development and their implication for the molecular pathology of myotonic dystrophy type 1

    Coleman, S. M., Prescott, A. R. & Sleeman, J. E. Mar 2014 In : Biochemical Journal. 458, 2, p. 267-280 14 p.

    Research output: Contribution to journalArticle

  21. Time-resolved quantitative proteomics implicates the core snRNP protein SmB together with SMN in neural trafficking

    Prescott, A. R., Bales, A., James, J., Trinkle-Mulcahy, L. & Sleeman, J. E. 15 Feb 2014 In : Journal of Cell Science. 127, 4, p. 812-827 16 p.

    Research output: Contribution to journalArticle

  22. AMPK: a cellular energy sensor primarily regulated by AMP

    Gowans, G. J. & Hardie, D. G. 1 Feb 2014 In : Biochemical Society Transactions. 42, 1, p. 71-75 5 p.

    Research output: Contribution to journalArticle

  23. RAM function is dependent on Kapβ2-mediated nuclear entry

    Gonatopoulos-Pournatzis, T. & Cowling, V. H. 1 Feb 2014 In : Biochemical Journal. 457, 3, p. 473-484 12 p.

    Research output: Contribution to journalArticle

  24. Cap-binding complex (CBC)

    Gonatopoulos-Pournatzis, T. & Cowling, V. H. 15 Jan 2014 In : Biochemical Journal. 457, 2, p. 231-242 12 p.

    Research output: Contribution to journalScientific review

  25. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

    Banerjee, S., Buhrlage, S. J., Huang, H-T., Deng, X., Zhou, W., Wang, J., Traynor, R., Prescott, A. R., Alessi, D. R. & Gray, N. S. 1 Jan 2014 In : Biochemical Journal. 457, 1, p. 215-225 11 p.

    Research output: Contribution to journalArticle

  26. Role of amino acid transporters in amino acid sensing

    Taylor, P. M. Jan 2014 In : American Journal of Clinical Nutrition. 99, 1, p. 2235-2305 71 p.

    Research output: Contribution to journalArticle

  27. A critical role for beta2 integrins in podosome formation, dynamics and TLR-signaled disassembly in dendritic cells

    Gawden-Bone, C., West, M. A., Morrison, V. L., Edgar, A. J., McMillan, S. J., Dill, B. D., Trost, M., Prescott, A., Fagerholm, S. C. & Watts, C. 2014 In : Journal of Cell Science. 37 p.

    Research output: Contribution to journalArticle

  28. AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

    Hardie, D. G. 2014 In : Journal of Internal Medicine. 17 p.

    Research output: Contribution to journalArticle

  29. Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK-TssFG sub-complex

    English, G., Byron, O., Cianfanelli, F. R., Prescott, A. R. & Coulthurst, S. J. 2014 In : Biochemical Journal. 461, 2, p. 291-304 14 p.

    Research output: Contribution to journalArticle

  30. Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insight

    Mahfouz, R., Khoury, R., Blachnio-Zabielska, A., Turban, S., Loiseau, N., Lipina, C., Stretton, C., Bourron, O., Ferré, P., Foufelle, F., Hundal, H. S. & Hajduch, E. 2014 In : PLoS ONE. 9, 7, 9 p.e101865

    Research output: Contribution to journalArticle

  31. High-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC proteomics

    Güther, M. L. S., Urbaniak, M., Tavendale, A., Prescott, A. & Ferguson, M. A. J. 2014 In : Journal of Proteome Research. 13, 6, p. 2796-2806 11 p.

    Research output: Contribution to journalArticle

  32. Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase

    Banerjee, S., Zagorska, A., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R. 2014 In : Biochemical Journal. 461, 2, p. 233-245 13 p.

    Research output: Contribution to journalArticle

  33. Leucoerythroblastic anaemia, abnormal bone scan and prostate cancer with a primary haematological diagnosis

    Preston, G., Meiklejohn, D. & Thomas, N. 2014 In : British Journal of Haematology. 1 p.

    Research output: Contribution to journalArticle

  34. Mechanism of Action of Compound-13: an α1-Selective Small Molecule Activator of AMPK

    Hunter, R. W., Foretz, M., Bultot, L., Fullerton, M. D., Deak, M., Ross, F. A., Hawley, S. A., Shpiro, N., Viollet, B., Barron, D., Kemp, B. E., Steinberg, G. R., Hardie, D. G. & Sakamoto, K. 2014 In : Chemistry & Biology. 21, 7, p. 866-879 14 p.

    Research output: Contribution to journalArticle

  35. Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation

    Pirkmajer, S., Kulkarni, S. S., Tom, R. Z., Ross, F. A., Hawley, S. A., Hardie, D. G., Zierath, J. R. & Chibalin, A. V. 2014 In : Diabetes. 10 p.

    Research output: Contribution to journalArticle

  36. Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model

    McMillan, S. J., Richards, H. E. & Crocker, P. R. 2014 In : Immunology Letters. 160, 1, p. 11-16 6 p.

    Research output: Contribution to journalArticle

  37. Siglec-mediated regulation of immune cell function in disease

    Macauley, M. S., Crocker, P. R. & Paulson, J. C. 2014 In : Nature Reviews Immunology. 14, 10, p. 653-666 14 p.

    Research output: Contribution to journalArticle

  38. Structural and functional basis for p38-MK2 activated Rsk signalling in TLR stimulated dendritic cells

    Zaru, R., Edgar, A. J., Hanauer, A. & Watts, C. 2014 In : Molecular and Cellular Biology. 30 p.

    Research output: Contribution to journalArticle

  39. Transcriptional regulation of IL-10 and its cell-specific role in vivo

    MacKenzie, K. F., Pattison, M. J. & Arthur, J. S. C. 2014 In : Critical Reviews in Immunology. 34, 4, p. 315-345 31 p.

    Research output: Contribution to journalArticle

  40. Characterization of Native Protein Complexes and Protein Isoform Variation Using Size-fractionation-based Quantitative Proteomics

    Kirkwood, K. J., Ahmad, Y., Larance, M. & Lamond, A. I. 1 Dec 2013 In : Molecular & Cellular Proteomics. 12, 12, p. 3851-3873 23 p.

    Research output: Contribution to journalArticle

  41. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis

    von Wilamowitz-Moellendorff, A., Hunter, R. W., García-Rocha, M., Kang, L., López-Soldado, I., Lantier, L., Patel, K., Peggie, M. W., Martínez-Pons, C., Voss, M., Calbó, J., Cohen, P. T. W., Wasserman, D. H., Guinovart, J. J. & Sakamoto, K. Dec 2013 In : Diabetes. 62, 12, p. 4070-4082 13 p.

    Research output: Contribution to journalArticle

  42. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

    Brown, S. J. , Madhok, V. B. & 32 others Saunders, S. P., Goh, C. S. M., Palmer, C. N. A., Porter, R. M., Cole, C., Campbell, L. E., Gierlinski, M., Barton, G. J., Schneider, G., Balmain, A., Prescott, A. R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y-A., Tavendale, R., Mukhopadhyay, S., Turner, S. W., Sullivan, F. M., Relton, C., Burn, J., Meggitt, S., Smith, C. H., Allen, M. A., Barker, J. N. W. N., Reynolds, N. J., Cordell, H. J., Irvine, A. D., McLean, W. H. I., Sandilands, A. & Fallon, P. G. Nov 2013 In : Journal of Allergy and Clinical Immunology. 132, 5, p. 1121-1129 9 p.

    Research output: Contribution to journalArticle

  43. A synthetic system for expression of components of a bacterial microcompartment

    Sargent, F., Davidson, F. A., Kelly, C. L., Binny, R., Christodoulides, N., Gibson, D., Johansson, E., Kozyrska, K., Licandro Lado, L., MacCallum, J., Montague, R., Ortmann, B., Owen, R., Coulthurst, S. J., Dupuy, L., Prescott, A. R. & Palmer, T. Nov 2013 In : Microbiology-SGM. 159, 11, p. 2427-2436 10 p.

    Research output: Contribution to journalArticle

  44. The interferon response to intracellular DNA: Why so many receptors?

    Unterholzner, L. Nov 2013 In : Immunobiology. 218, 11, p. 1312-1321 10 p.

    Research output: Contribution to journalArticle

  45. Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases

    Castor, D., Nair, N., Déclais, A-C., Lachaud, C., Toth, R., Macartney, T. J., Lilley, D. M. J., Arthur, J. S. C. & Rouse, J. 24 Oct 2013 In : Molecular Cell. 52, 2, p. 221-233 13 p.

    Research output: Contribution to journalArticle

  46. AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

    Gowans, G. J., Hawley, S. A., Ross, F. A. & Hardie, D. G. 1 Oct 2013 In : Cell Metabolism. 18, 4, p. 556-566 11 p.

    Research output: Contribution to journalArticle

  47. Mitochondrial Substrate Availability and its Role in Lipid-Induced Insulin Resistance and Proinflammatory Signalling in Skeletal Muscle

    Lipina, C., Macrae, K., Suhm, T., Weigert, C., Blachnio-Zabielska, A., Baranowksi, M., Gorski, J., Burgess, K. & Hundal, H. S. Oct 2013 In : Diabetes. 62, 10, p. 3426-3436 11 p.

    Research output: Contribution to journalArticle

  48. Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

    Emmerich, C. H., Ordureau, A., Strickson, S., Arthur, J. S. C., Pedrioli, P. G. A., Komander, D. & Cohen, P. 17 Sep 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 38, p. 15247-15252 6 p.

    Research output: Contribution to journalArticle

  49. Localization-dependent and -independent roles of SLX4 in regulating telomeres

    Wilson, J. S. J., Tejera, A. M., Castor, D., Toth, R., Blasco, M. A. & Rouse, J. 12 Sep 2013 In : Cell Reports. 4, 5, p. 853-860 8 p.

    Research output: Contribution to journalArticle

  50. Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells

    Ulvestad, M., Nordell, P., Asplund, A., Rehnström, M., Jacobsson, S., Holmgren, G., Davidson, L., Brolén, G., Edsbagge, J., Björquist, P., Küppers-Munther, B. & Andersson, T. B. 1 Sep 2013 In : Biochemical Pharmacology. 86, 5, p. 691-702 12 p.

    Research output: Contribution to journalArticle

  51. Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with γ-tubulin

    Voss, M., Campbell, K., Saranzewa, N., Campbell, D. G., Hastie, C. J., Peggie, M. W., Martin-Granados, C., Prescott, A. R. & Cohen, P. T. W. 1 Sep 2013 In : Cell Cycle. 12, 17, p. 2876-2887 12 p.

    Research output: Contribution to journalArticle

  52. Defining the role of DAG, mitochondrial function, and lipid deposition in palmitate-induced proinflammatory signaling and its counter-modulation by palmitoleate

    Macrae, K., Stretton, C., Lipina, C., Blachnio-Zabielska, A., Baranowski, M., Gorski, J., Marley, A. & Hundal, H. S. Sep 2013 In : Journal of Lipid Research. 54, 9, p. 2366-2378 13 p.

    Research output: Contribution to journalArticle

  53. Mitogen-activated protein kinases in innate immunity

    Arthur, J. S. C. & Ley, S. C. Sep 2013 In : Nature Reviews Immunology. 13, 9, p. 679-692 14 p.

    Research output: Contribution to journalArticle

  54. DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA

    Ordureau, A., Enesa, K., Nanda, S., Le Francois, B., Peggie, M., Prescott, A., Albert, P. R. & Cohen, P. 23 Aug 2013 In : Journal of Biological Chemistry. 288, 34, p. 24569-24580 12 p.

    Research output: Contribution to journalArticle

  55. The β2 integrin–kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo

    Morrison, V. L., MacPherson, M., Savinko, T., San Lek, H., Prescott, A. & Fagerholm, S. C. 22 Aug 2013 In : Blood. 122, 8, p. 1428-1436 9 p.

    Research output: Contribution to journalArticle

  56. BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm

    Hobley, L., Ostrowski, A., Rao, F. V., Bromley, K. M., Porter, M., Prescott, A. R., Macphee, C. E., van Aalten, D. M. F. & Stanley-Wall, N. R. 13 Aug 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13600-13605 6 p.

    Research output: Contribution to journalArticle

  57. AMPK: a target for drugs and natural products with effects on both diabetes and cancer

    Hardie, D. G. Jul 2013 In : Diabetes. 62, 7, p. 2164-2172 9 p.

    Research output: Contribution to journalArticle

  58. X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor

    Elkins, J. M., Wang, J., Deng, X., Pattison, M. J., Arthur, J. S. C., Erazo, T., Gomez, N., Lizcano, J. M., Gray, N. S. & Knapp, S. 13 Jun 2013 In : Journal of Medicinal Chemistry. 56, 11, p. 4413-4421 9 p.

    Research output: Contribution to journalArticle

  59. The spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow

    Lek, H. S., Morrison, V. L., Conneely, M., Campbell, P. A., McGloin, D., Kliche, S., Watts, C., Prescott, A. & Fagerholm, S. C. 24 May 2013 In : Journal of Biological Chemistry. 288, 21, p. 14698-14708 11 p.

    Research output: Contribution to journalArticle

  60. IFNβ autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages

    Pattison, M. J., MacKenzie, K. F., Elcombe, S. E. & Arthur, J. S. C. 21 May 2013 In : FEBS Letters. 587, 10, p. 1496-1503 8 p.

    Research output: Contribution to journalArticle

  61. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

    Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y-B., Taylor, P. M. & Cantrell, D. A. May 2013 In : Nature Immunology. 14, 5, p. 500-508 9 p.

    Research output: Contribution to journalArticle

  62. miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity

    Remenyi, J., van den Bosch, M. W. M., Palygin, O., Mistry, R. B., McKenzie, C., Macdonald, A., Hutvagner, G., Arthur, J. S. C., Frenguelli, B. G. & Pankratov, Y. 26 Apr 2013 In : PLoS ONE. 8, 4, 14 p.e62509

    Research output: Contribution to journalArticle

  63. LKB1 and AMPK and the cancer-metabolism link - ten years after

    Hardie, D. G. & Alessi, D. R. 15 Apr 2013 In : BMC Biology. 11, 11 p.36

    Research output: Contribution to journalArticle

  64. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

    Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3 Apr 2013 In : EMBO Journal. 32, 7, p. 1008-22 15 p.

    Research output: Contribution to journalArticle

  65. AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

    Dandapani, M. & Hardie, D. G. Apr 2013 In : Biochemical Society Transactions. 41, 2, p. 687-693 7 p.

    Research output: Contribution to journalArticle

  66. AMPKα1: a glucose sensor that controls CD8 T-cell memory

    Rolf, J., Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A. Apr 2013 In : European Journal of Immunology. 43, 4, p. 889-896 8 p.

    Research output: Contribution to journalArticle

  67. MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop

    MacKenzie, K. F., Van den Bosch, M. W. M., Naqvi, S., Elcombe, S. E., McGuire, V. A., Reith, A. D., Blackshear, P. J., Dean, J. L. E. & Arthur, J. S. C. Apr 2013 In : Molecular and Cellular Biology. 33, 7, p. 1456-1467 12 p.

    Research output: Contribution to journalArticle

  68. The system L1 amino acid transporter (SLC7A5) facilitates nutrient signalling in mouse skeletal muscle in vivo

    Poncet, N. & Taylor, P. M. Apr 2013 In : FASEB Journal. 27, Suppl., 1 p.350.4

    Research output: Contribution to journalMeeting abstract

  69. Dectin-1 Regulates IL-10 Production via a MSK1/2 and CREB Dependent Pathway and Promotes the Induction of Regulatory Macrophage Markers

    Elcombe, S. E., Naqvi, S., Van den Bosch, M. W. M., MacKenzie, K. F., Cianfanelli, F., Brown, G. D. & Arthur, J. S. C. 22 Mar 2013 In : PLoS ONE. 8, 3, 15 p.e60086

    Research output: Contribution to journalArticle

  70. LKB1 Mediates the Development of Conventional and Innate T Cells via AMP-Dependent Kinase Autonomous Pathways

    Zarrouk, M., Rolf, J. & Cantrell, D. A. 22 Mar 2013 In : PLoS ONE. 8, 3, 9 p.e60217

    Research output: Contribution to journalArticle

  71. Sialoadhesin ligand expression identifies a subpopulation of Foxp3- T cells with a distinct activation and glycosylation profile

    Kidder, D., Richards, H. E., Ziltener, H. J., Garden, O. A. & Crocker, P. R. 15 Mar 2013 In : Journal of Immunology. 190, 6, p. 2593-2602 10 p.

    Research output: Contribution to journalArticle

  72. Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling

    McMillan, S. J., Sharma, R. S., McKenzie, E. J., Richards, H. E., Zhang, J., Prescott, A. & Crocker, P. R. 14 Mar 2013 In : Blood. 121, 11, p. 2084-2094 11 p.

    Research output: Contribution to journalArticle

  73. Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors

    Horan, K. A., Hansen, K., Jakobsen, M. R., Holm, C. K., Søby, S., Unterholzner, L., Thompson, M., West, J. A., Iversen, M. B., Rasmussen, S. B., Ellermann-Eriksen, S., Kurt-Jones, E., Landolfo, S., Damania, B., Melchjorsen, J., Bowie, A. G., Fitzgerald, K. A. & Paludan, S. R. 1 Mar 2013 In : Journal of Immunology. 190, 5, p. 2311-2319 9 p.

    Research output: Contribution to journalArticle

  74. Global subcellular characterization of protein degradation using quantitative proteomics

    Larance, M., Ahmad, Y., Kirkwood, K. J., Ly, T. & Lamond, A. I. Mar 2013 In : Molecular & Cellular Proteomics. 12, 3, p. 638-650 13 p.

    Research output: Contribution to journalArticle

  75. Hormonal regulation of the Salt-inducible Kinase (SIK), a key mediator that controls hepatic gluconeogenesis

    Patel, K., Goransson, O., Sutherland, C. & Sakamoto, K. Mar 2013 In : Diabetic Medicine. 30, Suppl. 1, p. E2-E2 1 p.P577

    Research output: Contribution to journalMeeting abstract

  76. Hormonal regulation of the Salt-inducible Kinase (SIK), a key mediator that controls hepatic gluconeogenesis

    Patel, K., Goransson, O., Sutherland, C. & Sakamoto, K. Mar 2013

    Research output: Contribution to conferencePoster

  77. Insulin sensitising effects of monounsaturated and polyunsaturated fatty acids in skeletal muscle cells

    Nardi, F., Lipina, C., Magill, D. & Hundal, H. S. Mar 2013 In : Diabetic Medicine. 30, Suppl. 1, p. 49-49 1 p.P70

    Research output: Contribution to journalMeeting abstract

  78. Obesity-Induced Insulin Resistance in Human Skeletal Muscle Is Characterised by Defective Activation of p42/p44 MAP Kinase

    Ruiz-Alcaraz, A. J., Lipina, C., Petrie, J. R., Murphy, M. J., Morris, A. D., Sutherland, C. & Cuthbertson, D. J. 28 Feb 2013 In : PLoS ONE. 8, 2, e56928

    Research output: Contribution to journalArticle

  79. Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence

    Mansur, D. S., Maluquer de Motes, C., Unterholzner, L., Sumner, R. P., Ferguson, B. J., Ren, H., Strnadova, P., Bowie, A. G. & Smith, G. L. 28 Feb 2013 In : PLoS Pathogens. 9, 2, e1003183

    Research output: Contribution to journalArticle

  80. Metabolism of inflammation limited by AMPK and pseudo-starvation

    O'Neill, L. A. J. & Hardie, D. G. 17 Jan 2013 In : Nature. 493, 7432, p. 346-355 10 p.

    Research output: Contribution to journalArticle

  81. PGE2 induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway

    Mackenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G. A., Barton, G. J., Toth, R., Prescott, A. & Arthur, J. S. C. 15 Jan 2013 In : Journal of Immunology. 190, 2, p. 565-577 13 p.

    Research output: Contribution to journalArticle

  82. Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo

    Belch, J. J. F., Akbar, N., Alapati, V., Petrie, J., Arthur, S. & Khan, F. Jan 2013 In : Microvascular Research. 85, p. 86-92 7 p.

    Research output: Contribution to journalArticle

  83. The role of amino acid transporters in nutrition

    Poncet, N. & Taylor, P. M. Jan 2013 In : Current Opinion in Clinical Nutrition and Metabolic Care. 16, 1, p. 57-65 9 p.

    Research output: Contribution to journalArticle

  84. AMPK: mediating the metabolic effects of salicylate-based drugs?

    Steinberg, G. R., Dandapani, M. & Hardie, D. G. 2013 In : Trends in Endocrinology and Metabolism. 24, 10, p. 481-487 7 p.

    Research output: Contribution to journalArticle

  85. Chronic exposure of astrocytes to interferon-alpha reveals molecular changes related to Aicardi-Goutieres syndrome

    Cuadrado, E., Jansen, M. H., Anink, J., De Filippis, L., Vescovi, A. L., Watts, C., Aronica, E., Hol, E. M. & Kuijpers, T. W. 2013 In : Brain. 136, 1, p. 245-258 14 p.

    Research output: Contribution to journalArticle

  86. Cross talk between the Akt and p38α pathways in macrophages downstream of toll-like receptor signaling

    McGuire, V. A., Gray, A., Monk, C. E., Santos, S. G., Lee, K., Aubareda, A., Crowe, J., Ronkina, N., Schwermann, J., Batty, I. H., Leslie, N. R., Dean, J. L. E., O'Keefe, S. J., Boothby, M., Gaestel, M. & Arthur, J. S. C. 2013 In : Molecular and Cellular Biology. 33, 21, p. 4152-4165 14 p.

    Research output: Contribution to journalArticle

  87. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

    MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S. & Tauro, S. 2013 In : Scientific Reports. 3, 1275

    Research output: Contribution to journalArticle

  88. Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival

    Song, J., Lokmic, Z., Lämmermann, T., Rolf, J., Wu, C., Zhang, X., Hallmann, R., Hannocks, M-J., Horn, N., Ruegg, M. A., Sonnenberg, A., Georges-Labouesse, E., Winkler, T. H., Kearney, J. F., Cardell, S. & Sorokin, L. 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 31, p. E2915-E2924 10 p.

    Research output: Contribution to journalArticle

  89. Insulin sensitising effects of monounsaturated and polyunsaturated fatty acids in skeletal muscle cells

    Nardi, F., Lipina, C., Magill, D. & Hundal, H. S. 2013

    Research output: Contribution to conferencePoster

  90. p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia

    Groves, M. J., Johnson, C. E., James, J., Prescott, A. R., Cunningham, J., Haydock, S., Pepper, C., Fegan, C., Pirrie, L., Westwood, N. J., Coates, P. J., Ganley, I. G. & Tauro, S. 2013 In : British Journal of Cancer. 109, October, p. 2432=2444 13 p.

    Research output: Contribution to journalArticle

  91. Phospholipase C-eta 2 is required for retinoic acid-stimulated neurite growth

    Popovics, P., Gray, A., Arastoo, M., Finelli, D. K., Tan, A. J. L. & Stewart, A. J. 2013 In : Journal of Neurochemistry. 124, 5, p. 632-644 13 p.

    Research output: Contribution to journalArticle

  92. Phosphorylation of the actin binding protein drebrin at S647 is regulated by neuronal activity and PTEN

    Kreis, P., Hendricusdottir, R., Kay, L., Papageorgiou, I. E., van Diepen, M., Mack, T., Ryves, J., Harwood, A., Leslie, N. R., Kann, O., Parsons, M. & Eickholt, B. J. 2013 In : PLoS ONE. 8, 8, e71957

    Research output: Contribution to journalArticle

  93. PtdIns(4,5)P2-mediated cell signaling: emerging principles and PTEN as a paradigm for regulatory mechanism

    Gericke, A., Leslie, N. R., Lösche, M. & Ross, A. H. 2013 Lipid-mediated protein signaling. Capelluto, D. S. (ed.). Springer Netherlands, p. 85-104 20 p. (Advances in Experimental Medicine and Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  94. RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1

    Arthur, J. S. C. & 21 others Park, J., Al-Ramahi, I., Tan, Q., Mollema, N., Diaz-Garcia, J. R., Gallego-Flores, T., Lu, H-C., Lagalwar, S., Duvick, L., Kang, H., Lee, Y., Jafar-Nejad, P., Sayegh, L. S., Richman, R., Liu, X., Gao, Y., Shaw, C. A., Orr, H. T., Westbrook, T. F., Botas, J. & Zoghbi, H. Y. 2013 In : Nature. 498, 7454, p. 325-331 7 p.

    Research output: Contribution to journalArticle

  95. Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

    Fullerton, M. D., Galic, S., Marcinko, K., Sikkema, S., Pulinilkunnil, T., Chen, Z-P., O'Neill, H. M., Ford, R. J., Palanivel, R., O'Brien, M., Hardie, D. G., Macaulay, S. L., Schertzer, J. D., Dyck, J. R. B., van Denderen, B. J., Kemp, B. E. & Steinberg, G. R. 2013 In : Nature Medicine. 19, p. 1649-1654 6 p.

    Research output: Contribution to journalArticle

  96. The impact of KLF2 modulation on the transcriptional program and function of CD8 T Cells

    Preston, G. C., Feijoo-Carnero, C., Schurch, N., Cowling, V. H. & Cantrell, D. A. 2013 In : PLoS ONE. 8, 10, 16 p.e77537

    Research output: Contribution to journalArticle

  97. The LKB1-AMPK Pathway-Friend or Foe in Cancer?

    Hardie, D. G. 2013 In : Cancer Cell. 23, 2, p. 131-132 2 p.

    Research output: Contribution to journalEditorial

  98. The specificity of the interaction between αB-crystallin and desmin filaments and its impact on filament aggregation and cell viability

    Elliott, J. L., Der Perng, M., Prescott, A. R., Jansen, K. A., Koenderink, G. H. & Quinlan, R. A. 2013 In : Philosophical Transactions of the Royal Society B - Biological Sciences. 368, 1617, 15 p.20120375

    Research output: Contribution to journalArticle

  99. Two Phases of Inflammatory Mediator Production Defined by the Study of IRAK2 and IRAK1 Knock-in Mice

    Pauls, E., Nanda, S. K., Smith, H., Toth, R., Arthur, J. S. C. & Cohen, P. 2013 In : Journal of Immunology. 1203268

    Research output: Contribution to journalArticle

  100. Zinc finger protein 148 Is dispensable for primitive and definitive hematopoiesis in mice

    Nilton, A., Sayin, V. I., Staffas, A., Larsson, E., Rolf, J., Petit, M. M., Palmqvist, L., Swolin, B., Cardell, S. & Lindahl, P. 2013 In : PLoS ONE. 8, 7

    Research output: Contribution to journalArticle

  101. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells

    Finlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L., Rolf, J., Panteleyev, A. A., Okkenhaug, K. & Cantrell, D. A. 17 Dec 2012 In : Journal of Experimental Medicine. 209, 13, p. 2441-2453 13 p.

    Research output: Contribution to journalArticle

  102. Selective kinase inhibitors as tools for neuroscience research

    Martin, K. J. & Arthur, J. S. C. Dec 2012 In : Neuropharmacology. 63, 7, p. 1227-1237 11 p.

    Research output: Contribution to journalArticle

  103. Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

    McIver, E. G., Bryans, J., Birchall, K., Chugh, J., Drake, T., Lewis, S. J., Osborne, J., Smiljanic-Hurley, E., Tsang, W., Kamal, A., Levy, A., Newman, M., Taylor, D., Arthur, J. S. C., Clark, K. & Cohen, P. Dec 2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 23, p. 7169-7173 5 p.

    Research output: Contribution to journalArticle

  104. ZNRF2 is released from membranes by growth factors and with ZNRF1 regulates the Na+/K+ATPase

    Hoxhaj, G., Najafov, A., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 1 Oct 2012 In : Journal of Cell Science. 125, 19, p. 4662-4675 14 p.

    Research output: Contribution to journalArticle

  105. AKT independent glioma suppression by PTEN

    Zilidis, G., Tibarewal, P., Spinelli, L. & Leslie, N. R. Sep 2012 In : Journal of Neuro-Oncology. 14, p. 8-8 1 p.

    Research output: Contribution to journalMeeting abstract

  106. System L amino acid transporter 1 (slc7a5) expression is crucial for T cell blastogenesis

    Sinclair, L. V., Taylor, P. M. & Cantrell, D. A. Sep 2012 In : Immunology. 137, s1, p. 347-347 1 p.

    Research output: Contribution to journalMeeting abstract

  107. New vistas for treatment of obesity and diabetes?: Endocannabinoid signalling and metabolism in the modulation of energy balance

    Lipina, C., Rastedt, W., Irving, A. J. & Hundal, H. S. 1 Aug 2012 In : BioEssays. 34, 8, p. 681-691 11 p.

    Research output: Contribution to journalArticle

  108. P38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

    Risco, A., Del Dresno, C., Mambol, A., Alsina-Beauchamp, D., MacKenzie, K. F., Yang, H-T., Barber, D. F., Morcelle, C., Arthur, J. S. C., Ley, S. C., Ardavin, C. F. & Cuenda, A. 10 Jul 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 28, p. 11200-11205 6 p.

    Research output: Contribution to journalArticle

  109. IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold

    Dixon, M. J., Gray, A., Schenning, M., Agacan, M., Tempel, W., Tong, Y., Nedyalkova, L., Park, H-W., Leslie, N. R., van Aalten, D. M. F., Downes, C. P. & Batty, I. H. 29 Jun 2012 In : Journal of Biological Chemistry. 287, 27, p. 22483-22496 14 p.

    Research output: Contribution to journalArticle

  110. Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells

    Turban, S., Stretton, C., Drouin, O., Green, C. J., Watson, M. L., Gray, A., Ross, F., Lantier, L., Viollet, B., Hardie, D. G., Marette, A. & Hundal, H. S. 8 Jun 2012 In : Journal of Biological Chemistry. 287, 24, p. 20088-20099 12 p.

    Research output: Contribution to journalArticle

  111. E2F1-dependent methyl cap formation requires RNA pol II phosphorylation

    Aregger, M. & Cowling, V. H. 1 Jun 2012 In : Cell Cycle. 11, 11, p. 2146-2148 3 p.

    Research output: Contribution to journalArticle

  112. Cellular Responses to the Metal-Binding Properties of Metformin

    Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H-H., Xue, L., Jiang, H., Sakamoto, K., Prescott, A. R. & Rena, G. Jun 2012 In : Diabetes. 61, 6, p. 1423-1433 11 p.

    Research output: Contribution to journalArticle

  113. The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

    Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., Kemp, B. E., Sakamoto, K., Steinberg, G. R. & Hardie, D. G. 18 May 2012 In : Science. 336, 6083, p. 918-922 5 p.

    Research output: Contribution to journalArticle

  114. Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells

    Magister, Š., Obermajer, N., Mirković, B., Švajger, U., Renko, M., Softić, A., Romih, R., Colbert, J. D., Watts, C. & Kos, J. 1 May 2012 In : European Journal of Cell Biology. 91, 5, p. 391-401 11 p.

    Research output: Contribution to journalArticle

  115. A pan-endosomal protease inhibitor attenuates endosomal function and improves antigen presentation

    van Kasteren, S., Colbert, J., Berlin, I., Matthews, S., Groettrup, M., Mueller, M., Keane, D. & Watts, C. May 2012 In : Molecular Immunology. 51, 1, p. 34-34 1 p.

    Research output: Contribution to journalSpecial issue

  116. Organismal Carbohydrate and Lipid Homeostasis

    Hardie, D. G. May 2012 In : Cold Spring Harbor Perspectives in Biology. 4, 5, p. - 16 p.a006031

    Research output: Contribution to journalArticle

  117. Protein kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues

    Matthews, S. A., Lek, H. S., Morrison, V. L., Mackenzie, M. G., Zarrouk, M., Cantrell, D. & Fagerholm, S. C. May 2012 In : European Journal of Immunology. 42, 5, p. 1316-1326 11 p.

    Research output: Contribution to journalArticle

  118. Structures of the HIN domain: DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor

    Jin, T., Perry, A., Jiang, J., Smith, P., Curry, J. A., Unterholzner, L., Jiang, Z., Horvath, G., Rathinam, V. A., Johnstone, R. W., Hornung, V., Latz, E., Bowie, A. G., Fitzgerald, K. A. & Xiao, T. S. 20 Apr 2012 In : Immunity. 36, 4, p. 561-571 11 p.

    Research output: Contribution to journalArticle

  119. AMPK: a nutrient and energy sensor that maintains energy homeostasis

    Hardie, D. G., Ross, F. A. & Hawley, S. A. 1 Apr 2012 In : Nature Reviews Molecular Cell Biology. 13, 4, p. 251-262 12 p.

    Research output: Contribution to journalArticle

  120. The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a

    Cameron, A. R., Wallace, K., Logie, L., Prescott, A. R., Unterman, T. G., Harthill, J. & Rena, G. 1 Apr 2012 In : Biochemical Journal. 443, 1, p. 57-64 8 p.

    Research output: Contribution to journalArticle

  121. The role of ATM in response to metformin treatment and activation of AMPK reply

    Zhou, K., Bellenguez, C., Sutherland, C., Hardie, G., Palmer, C., Donnelly, P. & Pearson, E. Apr 2012 In : Nature Genetics. 44, 4, p. 361-362 2 p.

    Research output: Contribution to journalLetter

  122. Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

    Navarro, M. N., Sinclair, L. V., Feijoo-Carnero, C., Clarke, R., Matthews, S. A. & Cantrell, D. A. 15 Mar 2012 In : Biochemical Journal. 442, 3, p. 649-659 11 p.

    Research output: Contribution to journalArticle

  123. Both p110 alpha and p110 beta isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

    Berenjeno, I. M., Guillermet-Guibert, J., Pearce, W., Gray, A., Fleming, S. & Vanhaesebroeck, B. 15 Feb 2012 In : Biochemical Journal. 442, p. 151-159 9 p.

    Research output: Contribution to journalArticle

  124. Evolution of the vertebrate beaded filament protein, Bfsp2: comparing the in vitro assembly properties of a "tailed" zebrafish Bfsp2 to its "tailless" human orthologue

    Qu, B., Landsbury, A., Schoenthaler, H. B., Dahm, R., Liu, Y., Clark, J. I., Prescott, A. R. & Quinlan, R. A. Jan 2012 In : Experimental Eye Research. 94, 1, p. 192-202 11 p.

    Research output: Contribution to journalArticle

  125. The endosome-lysosome pathway and information generation in the immune system

    Watts, C. Jan 2012 In : Biochimica et Biophysica Acta. Proteins and Proteomics. 1824, 1, p. 14-21 8 p.

    Research output: Contribution to journalScientific review

  126. A role for PP1/NIPP1 in steering migration of human cancer cells

    Martin-Granados, C., Prescott, A. R., Van Dessel, N., Van Eynde, A., Arocena, M., Klaska, I. P., Görnemann, J., Beullens, M., Bollen, M., Forrester, J. V. & McCaig, C. D. 2012 In : PLoS ONE. 7, 7, e40769

    Research output: Contribution to journalArticle

  127. AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway

    Petti, C., Vegetti, C., Molla, A., Bersani, I., Cleris, L., Mustard, K. J., Formelli, F., Hardie, G. D., Sensi, M. & Anichini, A. 2012 In : Melanoma Research. 22, 5, p. 341-350 10 p.

    Research output: Contribution to journalArticle

  128. AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells

    Lee, C-W., Wong, L. L-Y., Tse, E. Y-T., Liu, H-F., Leong, V. Y-L., Lee, J. M-F., Hardie, D. G., Ng, I. O-L. & Ching, Y-P. 2012 In : Cancer Research. 72, 17, p. 4394-4404 11 p.

    Research output: Contribution to journalArticle

  129. Application of a novel highly sensitive activity-based probe for detection of cathepsin G

    Zou, F., Schmon, M., Sienczyk, M., Grzywa, R., Palesch, D., Boehm, B. O., Sun, Z. L., Watts, C., Schirmbeck, R. & Burster, T. 2012 In : Analytical Biochemistry. 421, 2, p. 667-72 6 p.

    Research output: Contribution to journalArticle

  130. CD33-related siglecs as potential modulators of inflammatory responses

    Crocker, P. R., McMillan, S. J. & Richards, H. E. 2012 In : Annals of the New York Academy of Sciences. 1253, p. 102-111 10 p.

    Research output: Contribution to journalArticle

  131. Disordered insulin secretion in the development of insulin resistance and Type 2 diabetes

    Schofield, C. J. & Sutherland, C. 2012 In : Diabetic Medicine. 29, 8, p. 972-979 8 p.

    Research output: Contribution to journalBook/Film/Article review

  132. Expression and function of thyroid hormone transporters in the microvillous plasma membrane of human term placental syncytiotrophoblast

    Loubière, L. S., Vasilopoulou, E., Glazier, J. D., Taylor, P. M., Franklyn, J. A., Kilby, M. D. & Chan, S. Y. 2012 In : Endocrinology. 153, 12, p. 6126-6135 10 p.

    Research output: Contribution to journalArticle

  133. Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback

    Pattison, M. J., MacKenzie, K. F. & Arthur, J. S. C. 2012 In : Journal of Immunology. 189, 6, p. 2784-2792 9 p.

    Research output: Contribution to journalArticle

  134. MC1R determines melanocyte viability upon UV irradiation by protecting PTEN activity

    Cao, J., Liu, F., Shen, J., Lenna, S., Jimenez-Cervantes, S., Leslie, N., Xu, G. X., Wang, Y. & Cui, R. 2012 In : Journal of Investigative Dermatology. 132, S1, p. S126 1 p.739

    Research output: Contribution to journalArticle

  135. Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus

    Choi, Y-S., Karelina, K., Alzate-Correa, D., Hoyt, K. R., Impey, S., Arthur, J. S. & Obrietan, K. 2012 In : Journal of Neurochemistry. 123, 5, p. 676-688 13 p.

    Research output: Contribution to journalArticle

  136. MSK1 regulates homeostatic and experience-dependent synaptic plasticity

    Corrêa, S. A. L., Hunter, C. J., Palygin, O., Wauters, S. C., Martin, K. J., McKenzie, C., McKelvey, K., Morris, R. G. M., Pankratov, Y., Arthur, J. S. C. & Frenguelli, B. 2012 In : Journal of Neuroscience. 32, 38, p. 13039-13051 13 p.

    Research output: Contribution to journalArticle

  137. Novel methods for the quantification of changes in actin organization in chondrocytes using fluorescent imaging and linear profiling

    Qusous, A., Parker, E., Geewan, C., Kapasi, A., Getting, S. J., Hucklebridge, F., Keshavarz, T. & Kerrigan, M. J. P. 2012 In : Microscopy Research and Technique. 75, 7, p. 991-999 9 p.

    Research output: Contribution to journalArticle

  138. Pellino1 Is Required for Interferon Production by Viral Double-stranded RNA

    Enesa, K., Ordureau, A., Smith, H., Barford, D., Cheung, P. C. F., Patterson-Kane, J., Arthur, J. S. C. & Cohen, P. 2012 In : Journal of Biological Chemistry. 287, 41, p. 34825-34835 11 p.

    Research output: Contribution to journalArticle

  139. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

    Clark, K., Mackenzie, K. F., Petkevicius, K., Kristariyanto, Y., Zhang, J., Choi, H. G., Peggie, M., Plater, L., Pedrioli, P. G. A., McIver, E., Gray, N. S., Arthur, J. S. C. & Cohen, P. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 42, p. 16986-91 6 p.

    Research output: Contribution to journalArticle

  140. PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

    Tibarewal, P., Zilidis, G., Spinelli, L., Schurch, N., Maccario, H., Gray, A., Perera, N. M., Davidson, L., Barton, G. J. & Leslie, N. R. 2012 In : Science Signaling. 5, 213, p. ra18

    Research output: Contribution to journalArticle

  141. The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser in adipocytes

    Henriksson, E., Jones, H. A., Patel, K., Peggie, M., Morrice, N., Sakamoto, K. & Göransson, O. 2012 In : Biochemical Journal. 444, 3, p. 503-514 12 p.

    Research output: Contribution to journalArticle

  142. The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor signaling

    Dzamko, N., Inesta-Vaquera, F., Zhang, J., Arthur, S., Cohen, P., Clark, K., Alessi, D. R., Xie, C., Cai, H., Tan, L., Choi, H., Gray, N. & Pedrioli, P. 2012 In : PLoS ONE. 7, 6, e39132

    Research output: Contribution to journalArticle

  143. The Phenotypic Characterization of A13/BACii, a Novel Bovine Chondrocytic Cell Line with Differentiation Potential

    Qusous, A., Kaneva, M., Can, V. C., Getting, S. J. & Kerrigan, M. J. P. 2012 In : Cells tissues organs. 196, 3, p. 251-261 11 p.

    Research output: Contribution to journalArticle

  144. The PTEN and Myotubularin phosphoinositide 3-phosphatases: linking lipid signalling to human disease

    Davies, E. M., Sheffield, D. A., Tibarewal, P., Fedele, C. G., Mitchell, C. A. & Leslie, N. R. 2012 Phosphoinositides I: enzymes of synthesis and degradation . Balla, T., Wymann, M. & York, J. D. (eds.). Dordrecht, Netherlands: Springer Netherlands, Vol. 58, p. 281-336 56 p. (Subcellular Biochemistry ).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  145. Internalization of Exogenous Cystatin F Supresses Cysteine Proteases and Induces the Accumulation of Single-chain Cathepsin L by Multiple Mechanisms

    Colbert, J. D., Matthews, S. P., Kos, J. & Watts, C. 9 Dec 2011 In : Journal of Biological Chemistry. 286, 49, p. 42082-42090 9 p.

    Research output: Contribution to journalArticle

  146. RAM/Fam103a1 is required for mRNA cap methylation

    Gonatopoulos-Pournatzis, T., Dunn, S., Bounds, R. & Cowling, V. H. 18 Nov 2011 In : Molecular Cell. 44, 4, p. 585-596 12 p.

    Research output: Contribution to journalArticle

  147. Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability

    Ikematsu, N., Dallas, M. L., Ross, F. A., Lewis, R. W., Rafferty, J. N., David, J. A., Suman, R., Peers, C., Hardie, D. G. & Evans, A. M. 1 Nov 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 44, p. 18132-18137 6 p.

    Research output: Contribution to journalArticle

  148. A Multifunctional Protease Inhibitor To Regulate Endolysosomal Function

    van Kasteren, S. I., Berlin, I., Colbert, J. D., Keane, D., Ovaa, H. & Watts, C. Nov 2011 In : ACS Chemical Biology. 6, 11, p. 1198-1204 7 p.

    Research output: Contribution to journalArticle

  149. Erratum to Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance (vol 54, pg 1596, 2011).

    Lipina, C. & Hundal, H. S. Nov 2011 In : Diabetologia. 54, 11, p. 2969-2969 1 p.

    Research output: Contribution to journalArticle

  150. Evidence for Direct Cross-Talk between Two Essential Nutrient-Sensing Enzymes: O-GlcNAc Transferase (OGT) and AMP-activated Kinase (AMPK)

    Bullen, J., Balsbaugh, J., Neumann, D., Hardie, G., Shabanowitz, J., Hunt, D. & Hart, G. Nov 2011 In : Glycobiology. 21, 11, p. 1487-1487 1 p.

    Research output: Contribution to journalBook/Film/Article review

  151. Recognition of immunogold markers in electron micrographs

    Wang, R., Pokhariya, H., McKenna, S. J. & Lucocq, J. Nov 2011 In : Journal of Structural Biology. 176, 2, p. 151-158 8 p.

    Research output: Contribution to journalArticle

  152. Early murine T-lymphocyte activation is accompanied by a switch from N-glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E

    Redelinghuys, P., Antonopoulos, A., Liu, Y., Campanero-Rhodes, M. A., McKenzie, E., Haslam, S. M., Dell, A., Feizi, T. & Crocker, P. R. 7 Oct 2011 In : Journal of Biological Chemistry. 286, 40, p. 34522-34532 11 p.

    Research output: Contribution to journalArticle

  153. Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells

    Watson, M. L., Macrae, K., Marley, A. E. & Hundal, H. S. 5 Oct 2011 In : PLoS ONE. 6, 10, p. - 12 p.e25975

    Research output: Contribution to journalArticle

  154. An intranucleolar body associated with rDNA

    Hutten, S., Prescott, A., James, J., Riesenberg, S., Boulon, S., Lam, Y. W. & Lamond, A. I. Oct 2011 In : Chromosoma. 120, 5, p. 481-499 19 p.

    Research output: Contribution to journalArticle

  155. AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

    Hardie, D. G. 15 Sep 2011 In : Genes & Development. 25, 18, p. 1895-1908 14 p.

    Research output: Contribution to journalScientific review

  156. Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7

    Unterholzner, L., Sumner, R. P., Baran, M., Ren, H., Mansur, D. S., Bourke, N. M., Randow, F., Smith, G. L. & Bowie, A. G. 8 Sep 2011 In : PLoS Pathogens. 7, 9, e1002247

    Research output: Contribution to journalArticle

  157. AMP-activated protein kinase: also regulated by ADP?

    Hardie, D. G., Carling, D. & Gamblin, S. J. Sep 2011 In : Trends in Biochemical Sciences. 36, 9, p. 470-477 8 p.

    Research output: Contribution to journalScientific review

  158. YuaB Functions Synergistically with the Exopolysaccharide and TasA Amyloid Fibers To Allow Biofilm Formation by Bacillus subtilis

    Ostrowski, A., Mehert, A., Prescott, A., Kiley, T. B. & Stanley-Wall, N. R. Sep 2011 In : Journal of Bacteriology. 193, 18, p. 4821-4831 11 p.

    Research output: Contribution to journalArticle

  159. Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial

    Hadad, S., Iwamoto, T., Jordan, L., Purdie, C., Bray, S., Baker, L., Jellema, G., Deharo, S., Hardie, D. G., Pusztai, L., Moulder-Thompson, S., Dewar, J. A. & Thompson, A. M. Aug 2011 In : Breast Cancer Research and Treatment. 128, 3, p. 783-794 12 p.

    Research output: Contribution to journalArticle

  160. Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2

    Konopatskaya, O., Matthews, S. A., Harper, M. T., Gilio, K., Cosemans, J. M. E. M., Williams, C. M., Navarro, M. N., Carter, D. A., Heemskerk, J. W. M., Leitges, M., Cantrell, D. & Poole, A. W. 14 Jul 2011 In : Blood. 118, 2, p. 416-424 9 p.

    Research output: Contribution to journalArticle

  161. Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance

    Lipina, C. & Hundal, H. S. Jul 2011 In : Diabetologia. 54, 7, p. 1596-1607 12 p.

    Research output: Contribution to journalScientific review

  162. SNAT2 transceptor signalling via mTOR: a role in cell growth and proliferation?

    Pinilla, J., Aledo, J. C., Cwiklinski, E., Hyde, R., Taylor, P. M. & Hundal, H. S. 1 Jun 2011 In : Frontiers in Bioscience (Elite Edition). E3, 4, p. 1289-1299 11 p.

    Research output: Contribution to journalArticle

  163. AMP-activated protein kinase, a tumor suppressor that opposes the metabolic changes in cancer cells

    Hardie, D. G. Jun 2011 In : FEBS Journal. 278, s1, p. 41-42 2 p.

    Research output: Contribution to journalBook/Film/Article review

  164. Innate DNA sensing moves to the nucleus

    Unterholzner, L. & Bowie, A. G. 19 May 2011 In : Cell Host & Microbe. 9, 5, p. 351-353 3 p.

    Research output: Contribution to journalArticle

  165. A Systemic Lupus Erythematosus-associated R77H Substitution in the CD11b Chain of the Mac-1 Integrin Compromises Leukocyte Adhesion and Phagocytosis

    MacPherson, M., Lek, H. S., Prescott, A. & Fagerholm, S. C. 13 May 2011 In : Journal of Biological Chemistry. 286, 19, p. 17303-17310 8 p.

    Research output: Contribution to journalArticle

  166. Asparagine endopeptidase is required for normal kidney physiology and homeostasis

    Miller, G., Matthews, S. P., Reinheckel, T., Fleming, S. & Watts, C. May 2011 In : FASEB Journal. 25, 5, p. 1606-1617 12 p.

    Research output: Contribution to journalArticle

  167. Proteomic tools for the analysis of transient interactions between metalloproteins

    Martínez-Fábregas, J., Rubio, S., Díaz-Quintana, A., Díaz-Moreno, I. & De La Rosa, M. A. May 2011 In : FEBS Journal. 278, 9, p. 1401-1410 10 p.

    Research output: Contribution to journalArticle

  168. Homeostasis in the vertebrate lens: mechanisms of solute exchange

    Dahm, R., van Marle, J., Quinlan, R. A., Prescott, A. R. & Vrensen, G. F. J. M. 27 Apr 2011 In : Philosophical Transactions of the Royal Society B - Biological Sciences. 366, 1568, p. 1265-1277 13 p.

    Research output: Contribution to journalScientific review

  169. Intracellular ATP Influences Synaptic Plasticity in Area CA1 of Rat Hippocampus via Metabolism to Adenosine and Activity-Dependent Activation of Adenosine A(1) Receptors

    zur Nedden, S., Hawley, S., Pentland, N., Hardie, D. G., Doney, A. S. & Frenguelli, B. 20 Apr 2011 In : Journal of Neuroscience. 31, 16, p. 6221-6234 14 p.

    Research output: Contribution to journalArticle

  170. Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor kappa B signalling in rat skeletal muscle cells by AMP-activated protein kinase

    Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, K. & Hundal, H. S. 15 Apr 2011 In : Biochemical Journal. 435, 2, p. 463-474 12 p.

    Research output: Contribution to journalArticle

  171. Signal transduction: how cells sense energy

    Hardie, D. G. 14 Apr 2011 In : Nature. 472, 7342, p. 176-177 2 p.

    Research output: Contribution to journalEditorial

  172. Selective Expression in Carotid Body Type I Cells of a Single Splice Variant of the Large Conductance Calcium- and Voltage-activated Potassium Channel Confers Regulation by AMP-activated Protein Kinase

    Ross, F. A., Rafferty, J. N., Dallas, M. L., Ogunbayo, O., Ikematsu, N., McClafferty, H., Tian, L., Widmer, H., Rowe, I. C. M., Wyatt, C. N., Shipston, M. J., Peers, C., Hardie, D. G. & Evans, A. M. 8 Apr 2011 In : Journal of Biological Chemistry. 286, 14, p. 11929-11936 8 p.

    Research output: Contribution to journalArticle

  173. A Screen for Novel Phosphoinositide 3-kinase Effector Proteins

    Dixon, M. J., Gray, A., Boisvert, F-M., Agacan, M., Morrice, N. A., Gourlay, R., Leslie, N. R., Downes, C. P. & Batty, I. H. Apr 2011 In : Molecular & Cellular Proteomics. 10, 4, p. - 13 p.003178

    Research output: Contribution to journalArticle

  174. Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

    Deng, X., Dzamko, N., Prescott, A., Davies, P., Liu, Q., Yang, Q., Lee, J-D., Patricelli, M. P., Nomanbhoy, T. K., Alessi, D. R. & Gray, N. S. Apr 2011 In : Nature Chemical Biology. 7, 4, p. 203-205 3 p.

    Research output: Contribution to journalArticle

  175. Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes

    Navarro, M. N., Goebel, J., Feijoo-Carnero, C., Morrice, N. & Cantrell, D. A. Apr 2011 In : Nature Immunology. 12, 4, p. 352-361 11 p.

    Research output: Contribution to journalArticle

  176. Sensing of energy and nutrients by AMP-activated protein kinase

    Hardie, D. G. Apr 2011 In : American Journal of Clinical Nutrition. 93, 4, p. 891S-896S 6 p.

    Research output: Contribution to journalArticle

  177. Effect of PI3K-and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKBI-deficient mice

    Garcia-Martinez, J. M., Wullschleger, S., Preston, G., Guichard, S., Fleming, S., Alessi, D. R. & Duce, S. L. 29 Mar 2011 In : British Journal of Cancer. 104, 7, p. 1116-1125 10 p.

    Research output: Contribution to journalArticle

  178. Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

    Richardson, C., Sakamoto, K., de los Heros, P., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R. 1 Mar 2011 In : Journal of Cell Science. 124, 5, p. 789-800 12 p.

    Research output: Contribution to journalArticle

  179. Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P-2 in regulating insulin sensitivity defined by knock-in analysis

    Wullschleger, S., Wasserman, D. H., Gray, A., Sakamoto, K. & Alessi, D. R. 1 Mar 2011 In : Biochemical Journal. 434, p. 265-274 10 p.

    Research output: Contribution to journalArticle

  180. Mechanisms of action of ceramide in different muscle cell lines

    Khoury, R., Turban, S., Loiseau, N., Stretton, C., Lasnier, F., Hundal, H., Ferre, P. & Hajduch, E. Mar 2011 In : Diabetes & Metabolism. 37, s1, p. A30-A30 1 p.P027

    Research output: Contribution to journalBook/Film/Article review

  181. Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism

    Macintyre, A. N., Finlay, D., Preston, G., Sinclair, L. V., Waugh, C. M., Tamas, P., Feijoo, C., Okkenhaug, K. & Cantrell, D. A. 25 Feb 2011 In : Immunity. 34, 2, p. 224-236 13 p.

    Research output: Contribution to journalArticle

  182. AMPK and autophagy get connected

    Hardie, D. G. 16 Feb 2011 In : EMBO Journal. 30, 4, p. 634-635 2 p.

    Research output: Contribution to journalEditorial

  183. ERK/p90(RSK)/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicua

    Dissanayake, K., Toth, R., Blakey, J., Olsson, O., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 1 Feb 2011 In : Biochemical Journal. 433, p. 515-525 11 p.

    Research output: Contribution to journalArticle

  184. A novel transcriptional repressor controlled by Erk/p90RSK/14-3-3 signalling impacts on expression of PEA3 Ets transcription factors

    Dissanayake, K., Toth, R., Olsson, O., Campbell, D., Prescott, A. & MacKintosh, C. Feb 2011 In : Clinical & Experimental Metastasis. 28, 2, p. 234-234 1 p.

    Research output: Contribution to journalBook/Film/Article review

  185. AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer

    Hardie, D. G. Feb 2011 In : Biochemical Society Transactions. 39, p. 1-13 13 p.

    Research output: Contribution to journalArticle

  186. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

    Morris, A. D. , Sutherland, C. & 49 others Zhou, K., Bellenguez, C., Spencer, C. C. A., Bennett, A. J., Coleman, R. L., Tavendale, R., Hawley, S. A., Donnelly, L. A., Schofield, C., Groves, C. J., Burch, L., Carr, F., Strange, A., Freeman, C., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Craddock, N., Deloukas, P., Dronov, S., Duncanson, A., Edkins, S., Gray, E., Hunt, S., Jankowski, J., Langford, C., Markus, H. S., Mathew, C. G., Plomin, R., Rautanen, A., Sawcer, S. J., Samani, N. J., Trembath, R., Viswanathan, A. C., Wood, N. W., Harries, L. W., Hattersley, A. T., Doney, A. S. F., Colhoun, H., Hardie, D. G., Peltonen, L., McCarthy, M. I., Holman, R. R., Palmer, C. N. A., Donnelly, P., Pearson, E. R. & Wellcome Trust Case Control Consor, GoDARTS UKPDS Diabet Pharmacogenet, MAGIC Investigators Feb 2011 In : Nature Genetics. 43, 2, p. 117-120 4 p.

    Research output: Contribution to journalLetter

  187. Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism: Plenary lecture

    Hardie, D. G. Feb 2011 In : Proceedings of the Nutrition Society. 70, 1, p. 92-99 8 p.

    Research output: Contribution to journalArticle

  188. Hypoxic pulmonary vasoconstriction: mechanisms of oxygen-sensing

    Evans, A. M., Hardie, D. G., Peers, C. & Mahmoud, A. Feb 2011 In : Current Opinion in Anaesthesiology. 24, 1, p. 13-20 8 p.

    Research output: Contribution to journalArticle

  189. Metabolism, migration and memory in cytotoxic T cells

    Finlay, D. & Cantrell, D. A. Feb 2011 In : Nature Reviews Immunology. 11, 2, p. 109-117 9 p.

    Research output: Contribution to journalArticle

  190. Why Starving Cells Eat Themselves

    Hardie, D. G. 28 Jan 2011 In : Science. 331, 6016, p. 410-411 2 p.

    Research output: Contribution to journalEditorial

  191. Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation?

    Cao, H. & Crocker, P. R. Jan 2011 In : Immunology. 132, 1, p. 18-26 9 p.

    Research output: Contribution to journalArticle

  192. The coordination of T-cell function by serine/threonine kinases

    Finlay, D. & Cantrell, D. Jan 2011 In : Cold Spring Harbor Perspectives in Biology. 3, 1, p. - 10 p.a002261

    Research output: Contribution to journalArticle

  193. Chemoenzymatic synthesis of sialooligosaccharides on arrays for studies of cell surface adhesion

    Sardzik, R., Sharma, R., Kaloo, S., Voglmeir, J., Crocker, P. R. & Flitsch, S. L. 2011 In : Chemical Communications. 47, 19, p. 5425-5427 3 p.

    Research output: Contribution to journalArticle

  194. TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

    Bouskila, M., Esoof, N., Gay, L., Fang, E. H., Deak, M., Begley, M. J., Cantley, L. C., Prescott, A., Storey, K. G. & Alessi, D. R. 2011 In : Biochemical Journal. 437, p. 157-167 11 p.

    Research output: Contribution to journalArticle

  195. Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet

    Jamieson, P. M., Cleasby, M. E., Kuperman, Y., Morton, N. M., Kelly, P. A. T., Brownstein, D. G., Mustard, K. J., Vaughan, J. M., Carter, R. N., Hahn, C. N., Hardie, D. G., Seckl, J. R., Chen, A. & Vale, W. W. 2011 In : Diabetologia. 54, 9, p. 2392-2403 12 p.

    Research output: Contribution to journalArticle

  196. Hot stuff: thyroid hormones and AMPK

    Hardie, D. G. Dec 2010 In : Cell Research. 20, 12, p. 1282-1284 3 p.

    Research output: Contribution to journalEditorial

  197. Investigating the role of murine siglec-E in the modulation of TLR responses and susceptibility to infection

    McKenzie, E. J., Richards, H. E., Zhang, J. Q., Mastroeni, P. & Crocker, P. R. Dec 2010 In : Immunology. 131, s1, p. 82-82 1 p.204

    Research output: Contribution to journalBook/Film/Article review

  198. Mechanism of activation of PKB/Akt by the protein phosphatase inhibitor Calyculin A

    Pozuelo-Rubio, M., Leslie, N. R., Murphy, J. & MacKintosh, C. Dec 2010 In : Cell Biochemistry and Biophysics. 58, 3, p. 147-156 10 p.

    Research output: Contribution to journalArticle

  199. Myc up-regulates formation of the mRNA methyl cap

    Cowling, V. H. Dec 2010 In : Biochemical Society Transactions. 38, p. 1598-1601 4 p.

    Research output: Contribution to journalScientific review

  200. Siglec-E is a negative regulator of acute pulmonary neutrophil recruitment induced by LPS

    McMillan, S. J., Cao, P., Richards, H. & Crocker, P. R. Dec 2010 In : Immunology. 131, s1, p. 72-72 1 p.153

    Research output: Contribution to journalBook/Film/Article review

  201. Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant V alpha 14 NKT cells and conventional T cells

    Finlay, D. K., Kelly, A. P., Clarke, R., Sinclair, L. V., Deak, M., Alessi, D. R. & Cantrell, D. A. 15 Nov 2010 In : Journal of Immunology. 185, 10, p. 5973-5982 10 p.

    Research output: Contribution to journalArticle

  202. Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

    Matthews, S. A., Navarro, M. N., Sinclair, L. V., Emslie, E., Feijoo-Carnero, C. & Cantrell, D. A. 15 Nov 2010 In : Biochemical Journal. 432, p. 153-163 11 p.

    Research output: Contribution to journalArticle

  203. IFI16 is an innate immune sensor for intracellular DNA

    Unterholzner, L., Keating, S. E., Baran, M., Horan, K. A., Jensen, S. B., Sharma, S., Sirois, C. M., Jin, T., Latz, E., Xiao, T. S., Fitzgerald, K. A., Paludan, S. R. & Bowie, A. G. Nov 2010 In : Nature Immunology. 11, 11, p. 997-1004 8 p.

    Research output: Contribution to journalArticle

  204. Migration Stimulating Factor (MSF) promotes fibroblast migration by inhibiting AKT

    Ellis, I. R., Jones, S. J., Lindsay, Y., Ohe, G., Schor, A. M., Schor, S. L. & Leslie, N. R. Nov 2010 In : Cellular Signalling. 22, 11, p. 1655-1659 5 p.

    Research output: Contribution to journalArticle

  205. PGC-1 alpha increases PDH content but does not change acute PDH regulation in mouse skeletal muscle

    Kiilerich, K., Adser, H., Jakobsen, A. H., Pedersen, P. A., Hardie, D. G., Wojtaszewski, J. F. P. & Pilegaard, H. Nov 2010 In : American Journal of Physiology: Regulatory Integrative and Comparative Physiology. 299, 5, p. R1350-R1359 10 p.

    Research output: Contribution to journalArticle

  206. Generation, validation and humanisation of a novel insulin resistant cell model

    Logie, L., Ruiz-Alcaraz, A. J., Schofield, C. J., Hundal, H. S., Feuerstein, G. Z., Brady, J. D., Crowther, D., Tommasi, A. M., Grierson, C. E., Shepherd, B., Morris, A. D., Hansen, M. K., Pearson, E. & Sutherland, C. 1 Oct 2010 In : Biochemical Pharmacology. 80, 7, p. 1042-1049 8 p.

    Research output: Contribution to journalArticle

  207. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

    Nichols, R. J., Dzamko, N., Morrice, N. A., Campbell, D. G., Deak, M., Ordureau, A., Macartney, T., Tong, Y., Shen, J., Prescott, A. R. & Alessi, D. R. 15 Sep 2010 In : Biochemical Journal. 430, p. 393-404 12 p.

    Research output: Contribution to journalArticle

  208. Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

    Dzamko, N., Deak, M., Hentati, F., Reith, A. D., Prescott, A. R., Alessi, D. R. & Nichols, R. J. 15 Sep 2010 In : Biochemical Journal. 430, p. 405-413 9 p.

    Research output: Contribution to journalArticle

  209. Targeting the Core of Transcription

    Hardie, D. G. 3 Sep 2010 In : Science. 329, 5996, p. 1158-1159 2 p.

    Research output: Contribution to journalEditorial

  210. Activating K-Ras mutations outwith "hotspot" codons in sporadic colorectal tumours: implications for personalised cancer medicine

    Smith, G., Bounds, R., Wolf, H., Pratt, N., Carey, F., Steele, R. & Wolf, C. Sep 2010 In : Journal of Pathology. 222, S1, p. S12-S12 1 p.

    Research output: Contribution to journalBook/Film/Article review

  211. Cellular depletion of atypical PKC lambda is associated with enhanced insulin sensitivity and glucose uptake in L6 rat skeletal muscle cells

    Stretton, C., Evans, A. & Hundal, H. S. Sep 2010 In : American Journal of Physiology, Endocrinology and Metabolism. 299, 3, p. E402-E412 11 p.

    Research output: Contribution to journalArticle

  212. In vivo evidence for the involvement of the carboxy terminal domain in assembling connexin 36 at the electrical synapse

    Helbig, I., Sammler, E., Eliava, M., Bolshakov, A. P., Rozov, A., Bruzzone, R., Monyer, H. & Hormuzdi, S. G. Sep 2010 In : Molecular and Cellular Neuroscience. 45, 1, p. 47-58 12 p.

    Research output: Contribution to journalArticle

  213. PTEN and Cancer

    Leslie, N. Sep 2010 In : Journal of Pathology. 222, S1, p. S2-S2 1 p.

    Research output: Contribution to journalMeeting abstract

  214. The Laforin-Malin Complex, Involved in Lafora Disease, Promotes the Incorporation of K63-linked Ubiquitin Chains into AMP-activated Protein Kinase beta Subunits

    Moreno, D., Towler, M. C., Hardie, D. G., Knecht, E. & Sanz, P. 1 Aug 2010 In : Molecular Biology of the Cell. 21, 15, p. 2578-2588 11 p.

    Research output: Contribution to journalArticle

  215. A fluorescence lifetime-based assay for serine and threonine kinases that is suitable for high-throughput screening

    Paterson, M. J., Dunsmore, C. J., Hurteaux, R., Maltman, B. A., Cotton, G. J. & Gray, A. 1 Jul 2010 In : Analytical Biochemistry. 402, 1, p. 54-64 11 p.

    Research output: Contribution to journalArticle

  216. Characterization of the specific interaction between sialoadhesin and sialylated Campylobacter jejuni lipooligosaccharides

    Heikema, A. P., Bergman, M. P., Richards, H., Crocker, P. R., Gilbert, M., Samsom, J. N., van Wamel, W. J. B., Endtz, H. P. & van Belkum, A. Jul 2010 In : Infection and Immunity. 78, 7, p. 3237-3246 10 p.

    Research output: Contribution to journalArticle

  217. Reactive oxygen species alters the electrophysiological properties and raises [Ca2+](i) in intracardiac ganglion neurons

    Dyavanapalli, J., Rimmer, K. & Harper, A. A. Jul 2010 In : American Journal of Physiology: Regulatory Integrative and Comparative Physiology. 299, 1, p. R42-R54 13 p.

    Research output: Contribution to journalArticle

  218. Activity of any class IA PI3K isoform can sustain cell proliferation and survival

    Foukas, L. C., Berenjeno, I. M., Gray, A., Khwaja, A. & Vanhaesebroeck, B. 22 Jun 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11381-11386 6 p.

    Research output: Contribution to journalArticle

  219. Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase

    Mankouri, J., Tedbury, P. R., Gretton, S., Hughes, M. E., Griffin, S. D. C., Dallas, M. L., Green, K. A., Hardie, D. G., Peers, C. & Harris, M. 22 Jun 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11549-11554 6 p.

    Research output: Contribution to journalArticle

  220. Use of Cells Expressing gamma Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

    Hawley, S. A., Ross, F. A., Chevtzoff, C., Green, K. A., Evans, A., Fogarty, S., Towler, M. C., Brown, L. J., Ogunbayo, O. A., Evans, A. M. & Hardie, D. G. 9 Jun 2010 In : Cell Metabolism. 11, 6, p. 554-565 12 p.

    Research output: Contribution to journalArticle

  221. Mechanisms involved in the enhancement of mammalian target of rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice

    Lipina, C., Kendall, H., McPherron, A. C., Taylor, P. M. & Hundal, H. S. 3 Jun 2010 In : FEBS Letters. 584, 11, p. 2403-2408 6 p.

    Research output: Contribution to journalArticle

  222. Myc regulation of mRNA cap methylation

    Cowling, V. H. & Cole, M. D. Jun 2010 In : Genes and Cancer. 1, 6, p. 576-579 4 p.

    Research output: Contribution to journalScientific review

  223. Dendritic cell podosomes are protrusive and invade the extracellular matrix using metalloproteinase MMP-14

    Gawden-Bone, C., Zhou, Z., King, E., Prescott, A., Watts, C. & Lucocq, J. 1 May 2010 In : Journal of Cell Science. 123, 9, p. 1427-1437 11 p.

    Research output: Contribution to journalArticle

  224. Tryptophan and iodothyronine transport interactions in HepG2 human hepatoma cells

    Ritchie, J. W. A. & Taylor, P. M. May 2010 In : Amino Acids. 38, 5, p. 1361-1367 7 p.

    Research output: Contribution to journalArticle

  225. Ubiquitination of PTEN (Phosphatase and Tensin Homolog) Inhibits Phosphatase Activity and Is Enhanced by Membrane Targeting and Hyperosmotic Stress

    Maccario, H., Perera, N. M., Gray, A., Downes, C. P. & Leslie, N. R. 23 Apr 2010 In : Journal of Biological Chemistry. 285, 17, p. 12620-12628 9 p.

    Research output: Contribution to journalArticle

  226. New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion

    Zagorska, A., Deak, M., Campbell, D. G., Banerjee, S., Hirano, M., Aizawa, S., Prescott, A. R. & Alessi, D. R. 30 Mar 2010 In : Science Signaling. 3, 115, p. - 13 p.ra25

    Research output: Contribution to journalArticle

  227. Leptin Regulates AMPA Receptor Trafficking via PTEN Inhibition

    Moult, P. R., Cross, A., Santos, S. D., Carvalho, A-L., Lindsay, Y., Connolly, C. N., Irving, A. J., Leslie, N. R. & Harvey, J. 17 Mar 2010 In : Journal of Neuroscience. 30, 11, p. 4088-4101 14 p.

    Research output: Contribution to journalArticle

  228. Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase

    Hurtado-Guerrero, R., Zusman, T., Pathak, S., Ibrahim, A. F. M., Shepherd, S., Prescott, A., Segal, G. & van Aalten, D. M. F. 15 Mar 2010 In : Biochemical Journal. 426, p. 281-292 12 p.

    Research output: Contribution to journalArticle

  229. Distinct Protease Requirements for Antigen Presentation In Vitro and In Vivo

    Matthews, S. P., Werber, I., Deussing, J., Peters, C., Reinheckel, T. & Watts, C. 1 Mar 2010 In : Journal of Immunology. 184, 5, p. 2423-2431 9 p.

    Research output: Contribution to journalArticle

  230. Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer

    Fogarty, S. & Hardie, D. G. Mar 2010 In : Biochimica et Biophysica Acta. Proteins and Proteomics. 1804, 3, p. 581-591 11 p.

    Research output: Contribution to journalArticle

  231. Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours: implications for personalised cancer medicine

    Smith, G., Bounds, R., Wolf, H., Steele, R., Carey, F. & Wolf, R. 16 Feb 2010 In : British Journal of Cancer. 102, 4, p. 693-703 11 p.

    Research output: Contribution to journalArticle

  232. Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP

    Fogarty, S., Hawley, S. A., Green, K. A., Saner, N., Mustard, K. J. & Hardie, D. G. 15 Feb 2010 In : Biochemical Journal. 426, p. 109-118 10 p.

    Research output: Contribution to journalArticle

  233. Enhanced mRNA cap methylation increases Cyclin D1 expression and promotes cell transformation

    Cowling, V. H. 11 Feb 2010 In : Oncogene. 29, 6, p. 930-936 7 p.

    Research output: Contribution to journalArticle

  234. Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN

    Davidson, L., Maccario, H., Perera, N. M., Yang, X., Spinelli, L., Tibarewal, P., Glancy, B., Gray, A., Weijer, C. J., Downes, C. P. & Leslie, N. R. 4 Feb 2010 In : Oncogene. 29, 5, p. 687-697 11 p.

    Research output: Contribution to journalArticle

  235. Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein

    Hale, B. G., Kerry, P. S., Jackson, D., Precious, B. L., Gray, A., Killip, M. J., Randall, R. E. & Russell, R. J. 2 Feb 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 5, p. 1954-1959 6 p.

    Research output: Contribution to journalArticle

  236. MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages

    Darragh, J., Ananieva, O., Courtney, A., Elcombe, S. & Arthur, J. S. C. 1 Feb 2010 In : Biochemical Journal. 425, p. 595-602 8 p.

    Research output: Contribution to journalArticle

  237. Prevention of high-fat diet-induced muscular lipid accumulation in rats by alpha lipoic acid is not mediated by AMPK activation

    Timmers, S., de Vogel-van den Bosch, J., Towler, M. C., Schaart, G., Moonen-Kornips, E., Mensink, R. P., Hesselink, M. K., Hardie, D. G. & Schrauwen, P. Feb 2010 In : Journal of Lipid Research. 51, 2, p. 352-359 8 p.

    Research output: Contribution to journalArticle

  238. Regulation of MAP Kinase-Directed Mitogenic and Protein Kinase B-Mediated Signaling by Cannabinoid Receptor Type 1 in Skeletal Muscle Cells

    Lipina, C., Stretton, C., Hastings, S., Hundal, J. S., Mackie, K., Irving, A. J. & Hundal, H. S. Feb 2010 In : Diabetes. 59, 2, p. 375-385 11 p.

    Research output: Contribution to journalArticle

  239. TLR signalling regulated antigen presentation in dendritic cells

    Watts, C., West, M. A. & Zaru, R. Feb 2010 In : Current Opinion in Immunology. 22, 1, p. 124-130 7 p.

    Research output: Contribution to journalScientific review

  240. Regulation of mRNA cap methylation

    Cowling, V. H. 15 Jan 2010 In : Biochemical Journal. 425, p. 295-302 8 p.

    Research output: Contribution to journalScientific review

  241. Legumain and cathepsin-L expression in human unstable carotid plaque

    Mattock, K. L., Gough, P. J., Humphries, J., Burnand, K., Patel, L., Suckling, K. E., Cuello, F., Watts, C., Gautel, M., Avkiran, M. & Smith, A. Jan 2010 In : Atherosclerosis. 208, 1, p. 83-89 7 p.

    Research output: Contribution to journalArticle

  242. LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells

    Tamas, P., Macintyre, A., Finlay, D., Clarke, R., Feijoo-Carnero, C., Ashworth, A. & Cantrell, D. Jan 2010 In : European Journal of Immunology. 40, 1, p. 242-253 12 p.

    Research output: Contribution to journalArticle

  243. Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration

    Finlay, D. & Cantrell, D. Jan 2010 In : Annals of the New York Academy of Sciences. 1183, p. 149-157 9 p.

    Research output: Contribution to journalArticle

  244. AMP-activated protein kinase

    Hardie, D. G. 2010 Handbook of cell signaling. Bradshaw, R. A. & Dennis, E. A. (eds.). 2nd ed. London: Academic Press, Vol. 2, p. 551-557 7 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  245. Analyzing the multiple mechanisms by which drugs and other xenobiotic compounds activate AMP-activated protein kinase

    Hardie, D. G. 2010 In : Therapeutic Research. 31, 6, p. 822-835 14 p.

    Research output: Contribution to journalArticle

  246. Cancer metabolism as a potential treatment target

    Hardie, G. 2010 In : Annals of Oncology. 21, Suppl. 4, p. iv21-iv21 1 p.3IN

    Research output: Contribution to journalMeeting abstract

  247. Cancer metabolism as a potential treatment target

    Hardie, G. 2010

    Research output: Contribution to conferencePaper

  248. Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction

    Loubiere, L. S., Vasilopoulou, E., Bulmer, J. N., Taylor, P. M., Stieger, B., Verrey, F., McCabe, C. J., Franklyn, J. A., Kilby, M. D. & Chan, S-Y. 2010 In : Placenta. 31, 4, p. 295-304 10 p.

    Research output: Contribution to journalArticle

  249. Iodothyronine Interactions with the System L1 Amino Acid Exchanger in 3T3-L1 Adipocytes

    Mitchell, F., Roy, L. A. & Taylor, P. M. 2010 In : Journal of Thyroid Research. 2010, 8 p.726098

    Research output: Contribution to journalArticle

  250. Regulation of mammary epithelial architecture by PTEN

    Lim, J. C., Davidson, L., Weerasinghe, N. R., Zilidis, G., Tibarewal, P., Spinelli, L. & Leslie, N. R. 2010 In : Breast Cancer Research. 12, p. S3-S3 1 p.P4

    Research output: Contribution to journalMeeting abstract

  251. Expression and modulation of TUB by insulin and thyroid hormone in primary rat and murine 3T3-L1 adipocytes

    Stretton, C., Litherland, G. J., Moynihan, A., Hajduch, E. & Hundal, H. S. 25 Dec 2009 In : Biochemical and Biophysical Research Communications. 390, 4, p. 1328-1333 6 p.

    Research output: Contribution to journalArticle

  252. S-Adenosyl Homocysteine Hydrolase Is Required for Myc-Induced mRNA Cap Methylation, Protein Synthesis, and Cell Proliferation

    Fernandez-Sanchez, M. E., Gonatopoulos-Pournatzis, T., Preston, G., Lawlor, M. A. & Cowling, V. H. 1 Dec 2009 In : Molecular and Cellular Biology. 29, 23, p. 6182-6191 10 p.

    Research output: Contribution to journalArticle

  253. Diverse regulatory roles for lysosomal proteases in the immune response

    Colbert, J. D., Matthews, S. P., Miller, G. & Watts, C. Nov 2009 In : European Journal of Immunology. 39, 11, p. 2955-2965 11 p.

    Research output: Contribution to journalScientific review

  254. Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

    Finlay, D. K., Sinclair, L. V., Feijoo, C., Waugh, C. M., Hagenbeek, T. J., Spits, H. & Cantrell, D. A. 26 Oct 2009 In : Journal of Experimental Medicine. 206, 11, p. 2441-2454 14 p.

    Research output: Contribution to journalArticle

  255. Reactive oxygen species modulate neuronal excitability in rat intrinsic cardiac ganglia

    Whyte, K. A., Hogg, R. C., Dyavanapalli, J., Harper, A. A. & Adams, D. J. 5 Oct 2009 In : Autonomic Neuroscience: Basic & Clinical. 150, 1-2, p. 45-52 8 p.

    Research output: Contribution to journalArticle

  256. Association of AMP-activated Protein Kinase Subunits With Glycogen Particles as Revealed In Situ by Immunoelectron Microscopy

    Bendayan, M., Londono, I., Kemp, B. E., Hardie, G. D., Ruderman, N. & Prentki, M. Oct 2009 In : Journal of Histochemistry & Cytochemistry. 57, 10, p. 963-971 9 p.

    Research output: Contribution to journalArticle

  257. ABC50 promotes translation initiation in mammalian cells

    Paytubi, S., Wang, X., Lam, Y. W., Izquierdo, L., Hunter, M. J., Jan, E., Hundal, H. S. & Proud, C. G. 4 Sep 2009 In : Journal of Biological Chemistry. 284, 36, p. 24061-24073 13 p.

    Research output: Contribution to journalArticle

  258. Histological evaluation of AMPK signalling in primary breast cancer

    Hadad, S. M., Baker, L., Quinlan, P. R., Robertson, K. E., Bray, S. E., Thomson, G., Kellock, D., Jordan, L. B., Purdie, C. A., Hardie, D. G., Fleming, S. & Thompson, A. M. 1 Sep 2009 In : BMC Cancer. 9, p. - 9 p.307

    Research output: Contribution to journalArticle

  259. Circulating neopterin and monocyte chemoattractant protein-1 are responsive to statin therapy but are poor predictors of cardiovascular events in type 2 diabetes in CARDS

    Colhoun, H. M., Betteridge, D. J., Durrington, P. N., Hitman, G., Neil, H. A. W., Charlton-Menys, V., Bao, W., DeMicco, D., Preston, G., Livingstone, S. & Fuller, J. H. Sep 2009 In : Diabetologia. 52, Supplement 1, p. S481-S481 1 p.1247

    Research output: Contribution to journalBook/Film/Article review

  260. Fate of Glycosylphosphatidylinositol (GPI)-Less Procyclin and Characterization of Sialylated Non-GPI-Anchored Surface Coat Molecules of Procyclic-Form Trypanosoma brucei

    Guether, M. L. S., Beattie, K., Lamont, D. J., James, J., Prescott, A. R. & Ferguson, M. A. J. Sep 2009 In : Eukaryotic Cell. 8, 9, p. 1407-1417 11 p.

    Research output: Contribution to journalArticle

  261. Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

    Pehmoller, C., Treebak, J. T., Birk, J. B., Chen, S., MacKintosh, C., Hardie, D. G., Richter, E. A. & Wojtaszewski, J. F. P. Sep 2009 In : American Journal of Physiology, Endocrinology and Metabolism. 297, 3, p. E665-E675 11 p.

    Research output: Contribution to journalArticle

  262. Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes

    Baird, F. E., Bett, K. J., MacLean, C., Tee, A. R., Hundal, H. S. & Taylor, P. M. Sep 2009 In : American Journal of Physiology, Endocrinology and Metabolism. 297, 3, p. E822-E829 8 p.

    Research output: Contribution to journalArticle

  263. Novel MHC Class I Structures on Exosomes

    Lynch, S., Santos, S. G., Campbell, E. C., Nimmo, A. M. S., Botting, C., Prescott, A., Antoniou, A. N. & Powis, S. J. 1 Aug 2009 In : Journal of Immunology. 183, 3, p. 1884-1891 8 p.

    Research output: Contribution to journalArticle

  264. Decreasing amputation rates in patients with diabetes-a population-based study

    Schofield, C. J., Yu, N., Jain, A. S. & Leese, G. P. Aug 2009 In : Diabetic Medicine. 26, 8, p. 773-777 5 p.

    Research output: Contribution to journalArticle

  265. The developmental mutant talpid(3) lacks primary cilia

    Bangs, F., Yin, Y., Paton, R., Prescott, A., James, J., Davey, M., Whitley, P., Genikhovich, G., Technau, U., Briscoe, J., Burt, D. & Tickle, C. Aug 2009 In : Mechanisms of Development. 126, p. S262-S262 1 p.

    Research output: Contribution to journalBook/Film/Article review

  266. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

    Garcia-Martinez, J. M., Moran, J., Clarke, R. G., Gray, A., Cosulich, S. C., Chresta, C. M. & Alessi, D. R. 1 Jul 2009 In : Biochemical Journal. 421, p. 29-42 14 p.

    Research output: Contribution to journalArticle

  267. Sensing and signaling functions associated with the SNAT2 amino acid transporter

    Hundal, H., Cwiklinski, E. & Taylor, P. M. Jul 2009 In : Amino Acids. 37, Suppl. 1, p. S8 1 p.

    Research output: Contribution to journalBook/Film/Article review

  268. AMP-activated protein kinase: a sensor of glycogen as well as AMP and ATP?

    McBride, A. & Hardie, D. G. May 2009 In : Acta Physiologica. 196, 1, p. 99-113 15 p.

    Research output: Contribution to journalScientific review

  269. Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status

    Babraj, J. A., Mustard, K., Sutherland, C., Towler, M. C., Chen, S., Smith, K., Green, K., Leese, G., Hardie, D. G., Rennie, M. J. & Cuthbertson, D. J. May 2009 In : American Journal of Physiology, Endocrinology and Metabolism. 296, 5, p. E1042-E1048 7 p.

    Research output: Contribution to journalArticle

  270. Activated cAMP receptors switch encystation into sporulation

    Kawabe, Y., Morio, T., James, J. L., Prescott, A. R., Tanaka, Y. & Schaap, P. 28 Apr 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 17, p. 7089-7094 6 p.

    Research output: Contribution to journalArticle

  271. Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling

    Hundal, H. S. & Taylor, P. M. Apr 2009 In : American Journal of Physiology, Endocrinology and Metabolism. 296, 4, p. E603-E613 11 p.

    Research output: Contribution to journalScientific review

  272. Glycosylation Directs Targeting and Activation of Cystatin F from Intracellular and Extracellular Sources

    Colbert, J. D., Plechanovova, A. & Watts, C. Apr 2009 In : Traffic. 10, 4, p. 425-437 13 p.

    Research output: Contribution to journalArticle

  273. Phenotype and genotype of a patient with McLeod syndrome

    Sammler, E., O'Riordan, J., Swingler, R., Poole, J. & Hormuzdi, S. G. Apr 2009 In : Journal of Neurology, Neurosurgery and Psychiatry. 80, 4, p. 456-456 1 p.CP4

    Research output: Contribution to journalBook/Film/Article review

  274. Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo

    Rajkhowa, M., Brett, S., Cuthbertson, D. J., Lipina, C., Ruiz-Alcaraz, A. J., Thomas, G. E., Logie, L., Petrie, J. R. & Sutherland, C. 15 Mar 2009 In : Biochemical Journal. 418, p. 665-671 7 p.

    Research output: Contribution to journalArticle

  275. Specific regulation of mRNA cap methylation by the c-Myc and E2F1 transcription factors

    Cole, M. D. & Cowling, V. H. 5 Mar 2009 In : Oncogene. 28, 9, p. 1169-1175 7 p.

    Research output: Contribution to journalArticle

  276. The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation

    Yin, Y., Bangs, F., Paton, I. R., Prescott, A., James, J., Davey, M. G., Whitley, P., Genikhovich, G., Technau, U., Burt, D. W. & Tickle, C. 15 Feb 2009 In : Development. 136, 4, p. 655-664 10 p.

    Research output: Contribution to journalArticle

  277. Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells

    Watson, M. L., Coghlan, M. & Hundal, H. S. 1 Feb 2009 In : Biochemical Journal. 417, 1, p. 791-801 11 p.

    Research output: Contribution to journalArticle

  278. The action of high K+ and aglycaemia on the electrical properties and synaptic transmission in rat intracardiac ganglion neurones in vitro

    Dyavanapalli, J., Rimmer, K. & Harper, A. A. 1 Feb 2009 In : Experimental Physiology. 94, 2, p. 201-212 12 p.

    Research output: Contribution to journalArticle

  279. Amino acid transporters: eminences grises of nutrient signalling mechanisms?

    Taylor, P. M. Feb 2009 In : Biochemical Society Transactions. 37, p. 237-241 5 p.

    Research output: Contribution to journalArticle

  280. The Glycogen-Binding Domain on the AMPK β Subunit Allows the Kinase to Act as a Glycogen Sensor

    McBride, A., Ghilagaber, S., Nikolaev, A. & Hardie, D. G. 7 Jan 2009 In : Cell Metabolism. 9, 1, p. 23-34 12 p.

    Research output: Contribution to journalArticle

  281. C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest

    Fogarty, S. & Hardie, D. G. 2 Jan 2009 In : Journal of Biological Chemistry. 284, 1, p. 77-84 8 p.

    Research output: Contribution to journalArticle

  282. mVps34 is activated following high-resistance contractions

    MacKenzie, M. G., Hamilton, D. L., Murray, J. T., Taylor, P. M. & Baar, K. 1 Jan 2009 In : Journal of Physiology. 587, 1, p. 253-260 8 p.

    Research output: Contribution to journalArticle

  283. A core MYC gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response

    Chandriani, S., Frengen, E., Cowling, V. H., Pendergrass, S. A., Perou, C. M., Whitfield, M. L. & Cole, M. D. 2009 In : PLoS ONE. 4, 8, e6693

    Research output: Contribution to journalArticle

  284. A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase

    Patel, N., Krishnan, S., Offman, M. N., Krol, M., Moss, C. X., Leighton, C., van Delft, F. W., Holland, M., Liu, J., Alexander, S., Dempsey, C., Ariffin, H., Essink, M., Eden, T. O. B., Watts, C., Bates, P. A. & Saha, V. 2009 In : Journal of Clinical Investigation. 119, 7, p. 1964-1973 10 p.

    Research output: Contribution to journalArticle

  285. A potential regulatory role for cathepsin V and its cognate inhibitor cystatin M/E in epidermal desquamation

    Cheng, T., Dolk, C., Caubet, C., Simon, M., Watts, C., Kamsteeg, M., Serre, G., Schalkwijk, J. & Zeeuwen, P. L. 2009 In : Journal of Investigative Dermatology. 129, p. S74 1 p.444

    Research output: Contribution to journalBook/Film/Article review

  286. AMP-activated protein kinase monitors respiratory gases as an index of respiratory function and energy supply at the whole-body level

    Evans, A. M., Peers, C. & Hardie, D. G. 2009 In : Journal of Physiological Sciences. 59, p. 405-405 1 p.

    Research output: Contribution to journalBook/Film/Article review

  287. Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation

    McDonald, A., Fogarty, S., Leclerc, I., Hill, E. V., Hardie, D. G. & Rutter, G. A. 2009 In : Islets. 1, 3, p. 198-209 12 p.

    Research output: Contribution to journalArticle

  288. Ion Channel Regulation by AMPK: The Route of Hypoxia-Response Coupling in the Carotid Body and Pulmonary Artery

    Evans, A. M., Hardie, D. G., Peers, C., Wyatt, C. N., Viollet, B., Kumar, P., Dallas, M. L., Ross, F., Ikematsu, N., Jordan, H. L., Barr, B. L., Rafferty, J. N. & Ogunbayo, O. 2009 Hypoxia and Consequences From Molecule to Malady. Peers, C., Haddad, G. G. & Chandel, N. S. (eds.). Oxford: Blackwell, p. 89-100 12 p. (Annals of the New York Academy of Sciences).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  289. Modulation of O-2 Sensitive K+ Channels by AMP-activated Protein Kinase

    Dallas, M. L., Scragg, J. L., Wyatt, C. N., Ross, F., Hardie, D. G., Evans, A. M. & Peers, C. 2009 Arterial Chemoreceptors. Gonzalez, C., Nurse, C. A. & Peers, C. (eds.). BERLIN: Springer, p. 57-63 7 p. (Advances in Experimental Medicine and Biology).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  290. Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle

    Treebak, J. T., Frosig, C., Pehmoller, C., Chen, S., Maarbjerg, S. J., Brandt, N., MacKintosh, C., Zierath, J. R., Hardie, D. G., Kiens, B., Richter, E. A., Pilegaard, H. & Wojtaszewski, J. F. P. 2009 In : Diabetologia. 52, 5, p. 891-900 10 p.

    Research output: Contribution to journalArticle

  291. Roles of the AMP-activated/SNF1 protein kinase family in the response to cellular stress

    Hardie, D. G. 2009 Cellular responses to stress. Downes, C. P., Wolf, C. R. & Lane, D. P. (eds.). London: Portland Press Ltd, p. 13-27 (Biochemical Society symposia; 64).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  292. Sensing of energy availability by the AMP-activated protein kinase

    Hardie, D. G. & McBride, A. 2009 In : Journal of Physiological Sciences. 59, p. 61-61 1 p.

    Research output: Contribution to journalBook/Film/Article review

  293. The significance of PTEN's protein phosphatase activity

    Leslie, N. R., Maccario, H., Spinelli, L. & Davidson, L. 2009 In : Advances in Enzyme Regulation. 49, 1, p. 190-196 7 p.

    Research output: Contribution to journalArticle

  294. Fluorescence image-guided surgery and repetitive Photodynamic Therapy in brain metastatic malignant melanoma

    Zilidis, G., Aziz, F., Telara, S. & Eljamel, M. S. Dec 2008 In : Photodiagnosis and Photodynamic Therapy. 5, 4, p. 264-266 3 p.

    Research output: Contribution to journalArticle

  295. Viral evasion and subversion of pattern-recognition receptor signalling

    Bowie, A. G. & Unterholzner, L. Dec 2008 In : Nature Reviews Immunology. 8, 12, p. 911-22 12 p.

    Research output: Contribution to journalArticle

  296. A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

    Towler, M. C., Fogarty, S., Hawley, S. A., Pan, D. A., Martin, D. M. A., Morrice, N. A., McCarthy, A., Galardo, M. N., Meroni, S. B., Cigorraga, S. B., Ashworth, A., Sakamoto, K. & Hardie, D. G. 15 Nov 2008 In : Biochemical Journal. 416, 1, p. 1-14 14 p.

    Research output: Contribution to journalArticle

  297. Ketoacidosis with pulmonary embolism: a formula to detect clots?

    Kidder, D., Pearson, E., Davidson, J., Swaminathan, K. & Petrie, J. R. 1 Nov 2008 In : British Journal of Diabetes and Vascular Disease. 8, 6, p. 301 1 p.

    Research output: Contribution to journalArticle

  298. Reactive Oxygen Species increases Intracellular Calcium, alters the Electrophysiological Properties and Synaptic Transmission In Intrinsic Cardiac Ganglion Neurons: in vitro

    Dyavanapalli, J., Rimmer, K. & Harper, A. A. 28 Oct 2008 In : Circulation. 118, 18, p. S359-S359 1 p.1623

    Research output: Contribution to journalBook/Film/Article review

  299. AMP-activated protein kinase and hypoxic pulmonary vasoconstriction

    Robertson, T. P., Mustard, K. J. W., Lewis, T. H., Clark, J. H., Wyatt, C. N., Blanco, E. A., Peers, C., Hardie, D. G. & Evans, A. M. 24 Oct 2008 In : European Journal of Pharmacology. 595, 1-3, p. 39-43 5 p.

    Research output: Contribution to journalArticle

  300. Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

    Green, C. J., Goransson, O., Kular, G. S., Leslie, N. R., Gray, A., Alessi, D. R., Sakamoto, K. & Hundal, H. S. 10 Oct 2008 In : Journal of Biological Chemistry. 283, 41, p. 27653-27667 15 p.

    Research output: Contribution to journalArticle

  301. Small molecules can have big effects on endurance

    Baar, K. & Hardie, D. G. Oct 2008 In : Nature Chemical Biology. 4, 10, p. 583-584 3 p.

    Research output: Contribution to journalComment/debate

  302. Transcription-independent functions of MYC: regulation of translation and DNA replication

    Cole, M. D. & Cowling, V. H. Oct 2008 In : Nature Reviews Molecular Cell Biology. 9, 10, p. 810-815 6 p.

    Research output: Contribution to journalScientific review

  303. Understanding PTEN regulation: PIP, polarity and protein stability

    Leslie, N. R., Batty, I. H., Maccario, H., Davidson, L. & Downes, C. P. 15 Sep 2008 In : Oncogene. 27, 41, p. 5464-5476 13 p.

    Research output: Contribution to journalArticle

  304. TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent

    West, M. A., Prescott, A. R., Chan, K. M., Zhou, Z., Rose-John, S., Scheller, J. & Watts, C. 8 Sep 2008 In : Journal of Cell Biology. 182, 5, p. 993-1005 13 p.

    Research output: Contribution to journalArticle

  305. AMPK: a key regulator of energy balance in the single cell and the whole organism

    Hardie, D. G. Sep 2008 In : International Journal of Obesity. 32, p. S7-S12 6 p.

    Research output: Contribution to journalArticle

  306. AMPK: a key regulator of energy balance in the single cell and the whole organism

    Hardie, D. G. Sep 2008 In : International Journal of Obesity. 32 Suppl 4, p. S7-12

    Research output: Contribution to journalArticle

  307. CD33-related sialic-acid-binding immunoglobulin-like lectins in health and disease

    McMillan, S. J. & Crocker, P. R. 11 Aug 2008 In : Carbohydrate Research. 343, 12, p. 2050-2056 7 p.

    Research output: Contribution to journalArticle

  308. The orphan adapter protein SLY1 as a novel anti-apoptotic protein required for thymocyte development

    Reis, B., Finkenstaedt, D., Finlay, D. K., Cantrell, D. A., Pfeffer, K. & Beer, S. Aug 2008 In : Wiener Klinische Wochenschrift. 120, Supplement 1, p. 20-20 1 p.057

    Research output: Contribution to journalBook/Film/Article review

  309. Expression and localisation of apical junctional complex proteins in lens epithelial cells

    Sugiyama, Y., Prescott, A. R., Tholozan, F. M. D., Ohno, S. & Quinlan, R. A. Jul 2008 In : Experimental Eye Research. 87, 1, p. 64-70 7 p.

    Research output: Contribution to journalArticle

  310. Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression

    Hines, R. M., Wu, L., Hines, D. J., Steenland, H., Mansour, S., Dahlhaus, R., Singaraja, R. R., Cao, X., Sammler, E., Hormuzdi, S. G., Zhuo, M. & El-Husseini, A. 11 Jun 2008 In : Journal of Neuroscience. 28, 24, p. 6055-6067 13 p.

    Research output: Contribution to journalArticle

  311. The synthesis of UDP-N-acetylglucosamine is essential for bloodstream form Trypanosoma brucei in vitro and in vivo and UDP-N-acetylglucosamine starvation reveals a hierarchy in parasite protein glycosylation

    Stokes, M. J., Guther, M. L. S., Turnock, D. C., Prescott, A. R., Martin, K. L., Alphey, M. S. & Ferguson, M. A. J. 6 Jun 2008 In : Journal of Biological Chemistry. 283, 23, p. 16147-16161 15 p.

    Research output: Contribution to journalArticle

  312. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

    Sauer, S., Bruno, L., Hertweck, A., Finlay, D., Leleu, M., Spivakov, M., Knight, Z. A., Cobb, B. S., Cantrell, D., O'Connor, E., Shokat, K. M., Fisher, A. G. & Merkenschlager, M. 3 Jun 2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 22, p. 7797-7802 6 p.

    Research output: Contribution to journalArticle

  313. AMPK and raptor: matching cell growth to energy supply

    Hardie, D. G. 9 May 2008 In : Molecular Cell. 30, 3, p. 263-265 3 p.

    Research output: Contribution to journalEditorial

  314. Cromakalim activates the K-ATP and enhances spontaneous transient outward potassium currents in rat saphenous arterial myocytes

    Fioretti, B., Trequattrini, C., Sforna, L., Harper, A., Catacuzzeno, L. & Franciolini, F. May 2008 In : Pharmacological Research. 57, 5, p. 398-402 5 p.

    Research output: Contribution to journalArticle

  315. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

    Bayascas, J. R., Wullschleger, S., Sakamoto, K., Garcia-Martinez, J. M., Clacher, C., Komander, D., van Aalten, D. M. F., Boini, K. M., Lan, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., van Diepen, J. A., Voshol, P. J., Lucocq, J. M. & Alessi, D. R. May 2008 In : Molecular and Cellular Biology. 28, 10, p. 3258-3272 15 p.

    Research output: Contribution to journalArticle

  316. Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

    Sinclair, L. V., Finlay, D., Feijoo, C., Cornish, G. H., Gray, A., Ager, A., Okkenhaug, K., Hagenbeek, T. J., Spits, H. & Cantrell, D. A. May 2008 In : Nature Immunology. 9, 5, p. 513-521 9 p.

    Research output: Contribution to journalArticle

  317. Location, location, location: identifying the neighborhoods of LPS signaling

    Watts, C. Apr 2008 In : Nature Immunology. 9, 4, p. 343-345 3 p.

    Research output: Contribution to journalEditorial

  318. Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase

    Liu, Z., Jang, S-W., Liu, X., Cheng, D., Peng, J., Yepes, M., Li, X., Matthews, S., Watts, C., Asano, M., Hara-Nishimura, I., Luo, H. R. & Ye, K. 28 Mar 2008 In : Molecular Cell. 29, 6, p. 665-678 14 p.

    Research output: Contribution to journalArticle

  319. Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha 1 following overload in LKB1 knockout mice

    Mcgee, S. L., Mustard, K. J., Hardie, D. G. & Baar, K. 15 Mar 2008 In : Journal of Physiology. 586, 6, p. 1731-1741 11 p.

    Research output: Contribution to journalArticle

  320. Targeting of PKC zeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

    Hajduch, E., Turban, S., Le Liepvre, X., Le Lay, S., Lipina, C., Dimopoulos, N., Dugail, I. & Hundal, H. S. 1 Mar 2008 In : Biochemical Journal. 410, p. 369-379 11 p.

    Research output: Contribution to journalArticle

  321. A role for ARF6 in dendritic cell podosome formation and migration

    Svensson, H. G., West, M. A., Mollahan, P., Prescott, A. R., Zaru, R. & Watts, C. Mar 2008 In : European Journal of Immunology. 38, 3, p. 818-828 11 p.

    Research output: Contribution to journalArticle

  322. What pharmacological resources to use to activate AMPK? AICAR, metformin or A-769662, a new AMPK activator

    Viollet, B., Foretz, M., Leclerc, J., Hardie, G. & Sakarmoto, K. Mar 2008 In : Diabetes & Metabolism. 34, s3, p. H23 2 p.

    Research output: Contribution to journalBook/Film/Article review

  323. An N-Myc truncation analogous to c-Myc-S induces cell proliferation independently of transactivation but dependent on Myc homology box II

    Cowling, V. H. & Cole, M. D. 21 Feb 2008 In : Oncogene. 27, 9, p. 1327-1332 6 p.

    Research output: Contribution to journalArticle

  324. Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis

    Hamilton, G., Colbert, J. D., Schuettelkopf, A. W. & Watts, C. 6 Feb 2008 In : EMBO Journal. 27, 3, p. 499-508 10 p.

    Research output: Contribution to journalArticle

  325. The interplay between viruses and innate immune signaling: recent insights and therapeutic opportunities

    Unterholzner, L. & Bowie, A. G. 1 Feb 2008 In : Biochemical Pharmacology. 75, 3, p. 589-602 14 p.

    Research output: Contribution to journalArticle

  326. Macular oedema is not predicted by perifoveal single blot haemorrhages

    Schofield, C. J., Ellis, J. D., Ellingford, A., Morris, A. D. & Leese, G. Feb 2008 In : Diabetic Medicine. 25, 2, p. 129-133 5 p.

    Research output: Contribution to journalArticle

  327. TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages

    Rousseau, S., Papoutsopoulou, M., Symons, A., Cook, D., Lucocq, J. M., Prescott, A. R., O'Garra, A., Ley, S. C. & Cohen, P. 15 Jan 2008 In : Journal of Cell Science. 121, 2, p. 149-154 6 p.

    Research output: Contribution to journalArticle

  328. Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease

    Hardie, D. G., Tontonoz, P. (ed.) & Nagy, L. (ed.) 9 Jan 2008 In : FEBS Letters. 582, 1, p. 81-89 9 p.

    Research output: Contribution to journalScientific review

  329. Key roles for AMP-activated protein kinase in the function of the carotid body?

    Wyatt, C. N., Pearson, S. A., Kumar, P., Peers, C., Hardie, D. G. & Evans, A. M. 1 Jan 2008 Integration in respiratory control: from genes to systems. Poulin, M. J. & Wilson, R. J. A. (eds.). Springer, p. 63-68 6 p. (Advances in Experimental Medicine and Biology; 2).

    Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

  330. Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases

    Martin-Granados, C., Philp, A., Oxenham, S. K., Prescott, A. R. & Cohen, P. T. W. 2008 In : International Journal of Biochemistry & Cell Biology. 40, 10, p. 2315-2332 18 p.

    Research output: Contribution to journalArticle

  331. Infection of legumes by beta-rhizobia

    James, E. K., Elliott, G. N., Chen, W. -M., Bontemps, C., Young, J. P. W., de Faria, S. M., dos Reis, F. B., Simon, M. F., Gross, E., Loureiro, M. F., Reis, V. M., Perin, L., Boddey, R. M., Hughes, C. E., Moulin, L., Prescott, A. R. & Sprent, J. I. 2008 Biological nitrogen fixation: towards poverty alleviation through sustainable agriculture. Dakora, F. D., Chimphango, S. B. M., Valentine, A. J., Elmerich, C. & Newton, W. E. (eds.). Dordrecht: Springer, p. 249-250 2 p. (Current Plant Science and Biotechnology in Agriculture).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  332. Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice

    Mooney, M. H., Fogarty, S., Stevenson, C., Gallagher, A. M., Palit, P., Hawley, S. A., Hardie, D. G., Coxon, G. D., Waigh, R. D., Tate, R. J., Harvey, A. L. & Furman, B. L. 2008 In : British Journal of Pharmacology. 153, 8, p. 1669-1677 9 p.

    Research output: Contribution to journalArticle

  333. Quantification of structures and gold labeling in transmission electron microscopy

    Lucocq, J. 2008 In : Methods in Cell Biology. 88, p. 59-82 24 p.

    Research output: Contribution to journalArticle

  334. Lymphoblasts produce a lysosomal protease that rapidly degrades L-asparaginase-implications for therapy in childhood acute lymphoblastic leukemia

    Patel, N., Krishnan, S., Offman, M. N., Moss, C. X., Ariffin, H., Vandelft, F. W., Yiannikouris, O., Leighton, C., Alexander, S., Holland, M., Khater, D., Liu, J. Z., Essink, M., Bates, P., Watts, C. & Saha, V. 16 Nov 2007 In : Blood. 110, 11, p. 821A-821A 1 p.

    Research output: Contribution to journalBook/Film/Article review

  335. p38 MAPK regulates COPII recruitment

    Wang, L. & Lucocq, J. M. 16 Nov 2007 In : Biochemical and Biophysical Research Communications. 363, 2, p. 317-21 5 p.

    Research output: Contribution to journalArticle

  336. AMPK and SNF1: snuffing out stress

    Hardie, D. G. 7 Nov 2007 In : Cell Metabolism. 6, 5, p. 339-40 2 p.

    Research output: Contribution to journalArticle

  337. Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling

    Lackey, J., Barnett, J., Davidson, L., Batty, I. H., Leslie, N. R. & Downes, C. P. Nov 2007 In : Oncogene. 26, 50, p. 7132-7142 11 p.

    Research output: Contribution to journalArticle

  338. Reorganization of centrosomal marker proteins coincides with epithelial cell differentiation in the vertebrate lens

    Dahm, R., Procter, J. E., Ireland, M. E., Lo, W-K., Mogensen, M. M., Quinlan, R. A. & Prescott, A. R. Nov 2007 In : Experimental Eye Research. 85, 5, p. 696-713 18 p.

    Research output: Contribution to journalArticle

  339. Reorganization of centrosomal marker proteins coincides with epithelial cell differentiation in the vertebrate lens

    Dahm, R., Procter, J. E., Ireland, M. E., Lo, W-K., Mogensen, M. M., Quinlan, R. A. & Prescott, A. R. Nov 2007 In : Experimental Eye Research. 85, 5, p. 696-713 18 p.

    Research output: Contribution to journalArticle

  340. The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

    Zaru, R., Ronkina, N., Gaestel, M., Arthur, S. & Watts, C. Nov 2007 In : Nature Immunology. 8, 11, p. 1227-1235 9 p.

    Research output: Contribution to journalArticle

  341. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR

    Geraghty, K. M., Chen, S., Harthill, J. E., Ibrahim, A. F., Toth, R., Morrice, N. A., Vandermoere, F., Moorhead, G. B., Hardie, D. G. & MacKintosh, C. 15 Oct 2007 In : Biochemical Journal. 407, p. 231-241 11 p.

    Research output: Contribution to journalArticle

  342. The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2

    Batty, I. H., Van der Kaay, J., Gray, A., Telfer, J. F., Dixon, M. J. & Downes, C. P. 15 Oct 2007 In : Biochemical Journal. 407, 2, p. 255-266 12 p.

    Research output: Contribution to journalArticle

  343. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

    Hardie, D. G. Oct 2007 In : Nature Reviews Molecular Cell Biology. 8, 10, p. 774-85 12 p.

    Research output: Contribution to journalArticle

  344. MSK regulate TCR-induced CREB phosphorylation but not immediate early gene transcription

    Kaiser, M., Wiggin, G. R., Lightfoot, K., Arthur, J. S. C. & Macdonald, A. Sep 2007 In : European Journal of Immunology. 37, 9, p. 2583-95 13 p.

    Research output: Contribution to journalArticle

  345. PTEN is destabilized by phosphorylation on Thr366

    Maccario, H., Perera, N. M., Davidson, L., Downes, C. P. & Leslie, N. R. 1 Aug 2007 In : Biochemical Journal. 405, 3, p. 439-444 6 p.

    Research output: Contribution to journalArticle

  346. Scottish foot ulcer risk score predicts foot ulcer healing in a regional specialist foot clinic

    Leese, G., Schofield, C., McMurray, B., Libby, G., Golden, J., MacAlpine, R., Cunningham, S., Morris, A., Flett, M. & Griffiths, G. Aug 2007 In : Diabetes Care. 30, 8, p. 2064-2069 6 p.

    Research output: Contribution to journalArticle

  347. Notch-induced T cell development requires phosphoinositide-dependent kinase 1

    Kelly, A. P., Finlay, D. K., Hinton, H. J., Clarke, R. G., Fiorini, E., Radtke, F. & Cantrell, D. A. 25 Jul 2007 In : EMBO Journal. 26, 14, p. 3441-3450 10 p.

    Research output: Contribution to journalArticle

  348. Distinct sensor pathways in the hierarchical control of SNAT2, a putative amino acid transceptor, by amino acid availability

    Hyde, R., Cwiklinski, E. L., MacAulay, K., Taylor, P. M. & Hundal, H. S. 6 Jul 2007 In : Journal of Biological Chemistry. 282, 27, p. 19788-19798 11 p.

    Research output: Contribution to journalArticle

  349. Differential redox regulation within the PTP superfamily

    Ross, S. H., Lindsay, Y., Safrany, S. T., Lorenzo, O., Villa, F., Toth, R., Clague, M. J., Downes, C. P. & Leslie, N. R. Jul 2007 In : Cellular Signalling. 19, 7, p. 1521-1530 10 p.

    Research output: Contribution to journalArticle

  350. Tissue uptake of thyroid hormone by amino acid transporters

    Taylor, P. M. & Ritchie, J. W. A. Jun 2007 In : Best Practice & Research Clinical Endocrinology & Metabolism. 21, 2, p. 237-251 15 p.

    Research output: Contribution to journalArticle

  351. ZnT5 variant B is a bidirectional zinc transporter and mediates zinc uptake in human intestinal Caco-2 cells

    Valentine, R. A., Jackson, K. A., Christie, G. R., Mathers, J. C., Taylor, P. M. & Ford, D. 11 May 2007 In : Journal of Biological Chemistry. 282, 19, p. 14389-14393 5 p.

    Research output: Contribution to journalArticle

  352. Reconstruction of a pathway of antigen processing and class II MHC peptide capture

    Moss, C. X., Tree, T. I. & Watts, C. 18 Apr 2007 In : EMBO Journal. 26, 8, p. 2137-47 11 p.

    Research output: Contribution to journalArticle

  353. Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS

    McCoy, C. E., Macdonald, A., Morrice, N. A., Campbell, D. G., Deak, M., Toth, R., McIlrath, J. & Arthur, J. S. C. 15 Mar 2007 In : Biochemical Journal. 402, 3, p. 491-501 11 p.

    Research output: Contribution to journalArticle

  354. AMP-activated protein kinase in metabolic control and insulin signaling

    Towler, M. C. & Hardie, D. G. 16 Feb 2007 In : Circulation Research. 100, 3, p. 328-41 14 p.

    Research output: Contribution to journalArticle

  355. Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit

    Scott, J. W., Ross, F. A., Liu, J. K. D. & Hardie, D. G. 7 Feb 2007 In : EMBO Journal. 26, 3, p. 806-15 10 p.

    Research output: Contribution to journalArticle

  356. AMP-activated protein kinase as a drug target

    Hardie, D. G. Feb 2007 In : Annual Review of Pharmacology and Toxicology. 47, p. 185-210 26 p.

    Research output: Contribution to journalArticle

  357. Proximal effects of Toll-like receptor activation in dendritic cells

    Watts, C., Zaru, R., Prescott, A. R., Wallin, R. P. & West, M. A. Feb 2007 In : Current Opinion in Immunology. 19, 1, p. 73-8 6 p.

    Research output: Contribution to journalArticle

  358. A neural protection racket: AMPK and the GABAB receptor

    Hardie, D. G. & Frenguelli, B. G. 18 Jan 2007 In : Neuron. 53, 2, p. 159-162 4 p.

    Research output: Contribution to journalArticle

  359. PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration

    Leslie, N. R., Yang, X., Downes, C. P. & Weijer, C. J. Jan 2007 In : Current Biology. 17, 2, p. 115-125 11 p.

    Research output: Contribution to journalArticle

  360. 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men

    Cuthbertson, D. J., Babraj, J. A., Mustard, K. J. W., Towler, M. C., Green, K. A., Wackerhage, H., Leese, G. P., Baar, K., Thomason-Hughes, M., Sutherland, C., Hardie, D. G. & Rennie, M. J. 2007 In : Diabetes. 56, 8, p. 2078-2084 7 p.

    Research output: Contribution to journalArticle

  361. Age-related HMG-CoA reductase deregulation depends on ROS-induced p38 activation

    Pallottini, V., Martini, C., Cavallini, G., Bergamini, E., Mustard, K. J., Hardie, D. G. & Trentalance, A. 2007 In : Mechanisms of Ageing and Development. 128, 11-12, p. 688-695 8 p.

    Research output: Contribution to journalArticle

  362. Biochemistry. Balancing cellular energy

    Hardie, D. G. 2007 In : Science. 315, 5819, p. 1671-1672 2 p.

    Research output: Contribution to journalArticle

  363. Burkholderia phymatum is a highly effective nitrogen-fixing symbiont of Mimosa spp. and fixes nitrogen ex planta

    Elliott, G. N., Chen, W-M., Chou, J-H., Wang, H-C., Sheu, S-Y., Perin, L., Reis, V. M., Moulin, L., Simon, M. F., Bontemps, C., Sutherland, J. M., Bessi, R., de Faria, S. M., Trinick, M. J., Prescott, A. R., Sprent, J. I. & James, E. K. 2007 In : New Phytologist. 173, 1, p. 168-180 13 p.

    Research output: Contribution to journalArticle

  364. c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1

    Cowling, V. H., D'Cruz, C. M., Chodosh, L. A. & Cole, M. D. 2007 In : Molecular and Cellular Biology. 27, 14, p. 5135-5146 12 p.

    Research output: Contribution to journalArticle

  365. Efficient quantitative morphological phenotyping of genetically altered organisms using stereology

    Lucocq, J. M. 2007 In : Transgenic Research. 16, 2, p. 133-145 13 p.

    Research output: Contribution to journalArticle

  366. How I became a biochemist

    Hardie, D. G. 2007 In : IUBMB Life. 59, 12, p. 793-796 4 p.

    Research output: Contribution to journalArticle

  367. MAPK activation by radio waves

    Arthur, J. S. C. 2007 In : Biochemical Journal. 405, 3, p. e5-e6 2 p.

    Research output: Contribution to journalArticle

  368. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase

    Goransson, O., McBride, A., Hawley, S. A., Ross, F. A., Shpiro, N., Foretz, M., Viollet, B., Hardie, D. G. & Sakamoto, K. 2007 In : Journal of Biological Chemistry. 282, 45, p. 32549-32560 12 p.

    Research output: Contribution to journalArticle

  369. Metabolic switching of PI3K-dependent lipid signals

    Downes, P., Leslie, N. R., Batty, I. H. & van der Kaay, J. 2007 In : Biochemical Society Transactions. 35, 2, p. 188-192 5 p.

    Research output: Contribution to journalArticle

  370. Stimulation of PI 3-kinase signaling via inhibition of the tumor suppressor phosphatase, PTEN

    Downes, C. P., Ross, S., Maccario, H., Perera, N., Davidson, L. & Leslie, N. R. 2007 In : Advances in Enzyme Regulation. 47, p. 184-194 11 p.

    Research output: Contribution to journalArticle

  371. The PPARdelta agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cells

    Dimopoulos, N., Watson, M., Green, C. & Hundal, H. S. 2007 In : FEBS Letters. 581, 24, p. 4743-4748 6 p.

    Research output: Contribution to journalArticle

  372. Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression

    Lindsay, Y., McCoull, D., Davidson, L., Leslie, N. R., Fairservice, A., Gray, A., Lucocq, J. & Downes, C. P. Dec 2006 In : Journal of Cell Science. 119, 24, p. 5160-5168 9 p.

    Research output: Contribution to journalArticle

  373. A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression

    Finlay, D., Ruiz-Alcaraz, A. J., Lipina, C., Perrier, S. & Sutherland, C. Oct 2006 In : Journal of Molecular Endocrinology. 37, 2, p. 227-237 11 p.

    Research output: Contribution to journalArticle

  374. Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue

    Baird, F. E., Pinilla-Tenas, J. J., Ogilvie, W. L. J., Ganapathy, V., Hundal, H. S. & Taylor, P. M. 15 Jul 2006 In : Biochemical Journal. 397, 2, p. 369-375 7 p.

    Research output: Contribution to journalArticle

  375. Structural basis of reduction-dependent activation of human cystatin F

    Schüttelkopf, A. W., Hamilton, G., Watts, C. & van Aalten, D. M. F. 16 Jun 2006 In : Journal of Biological Chemistry. 281, 24, p. 16570-16575 6 p.

    Research output: Contribution to journalArticle

  376. A conserved Myc protein domain, MBIV, regulates DNA binding, apoptosis, transformation, and G2 arrest

    Cowling, V. H., Chandriani, S., Whitfield, M. L. & Cole, M. D. Jun 2006 In : Molecular and Cellular Biology. 26, 11, p. 4226-4239 14 p.

    Research output: Contribution to journalArticle

  377. A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic β-cells

    Ning, K., Miller, L. C., Laidlaw, H. A., Burgess, L. A., Perera, N. M., Downes, C. P., Leslie, N. R. & Ashford, M. L. J. Jun 2006 In : The EMBO Journal. 25, 11, p. 2377-2387 11 p.

    Research output: Contribution to journalArticle

  378. Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226

    Liu, H. K., Perrier, S., Lipina, C., Finlay, D., McLauchlan, H., Hastie, C. J., Hundal, H. S., Sutherland, C. & Sutherland, C. 6 Apr 2006 In : BMC Molecular Biology. 7, p. - 12 p.14

    Research output: Contribution to journalArticle

  379. The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

    Jaleel, M., Villa, F., Deak, M., Toth, R., Prescott, A. R., van Aalten, D. M. F. & Alessi, D. R. 15 Mar 2006 In : Biochemical Journal. 394, 3, p. 545-555 11 p.

    Research output: Contribution to journalArticle

  380. Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha

    Sakamoto, K., Zarrinpashneh, E., Budas, G., Pouleur, A-C., Dutta, A., Prescott, A. R., Vanoverschelde, J-L., Ashworth, A., Jovanovic, A., Alessi, D. & Bertrand, L. 2006 In : American Journal of Physiology, Endocrinology and Metabolism. 290, 5, p. E780-E788

    Research output: Contribution to journalArticle

  381. Developmental changes in electrophysiological properties and synaptic transmission in rat intracardiac ganglion neurons

    Rimmer, K. & Harper, A. A. 2006 In : Journal of Neurophysiology. 95, 6, p. 3543-3552 10 p.

    Research output: Contribution to journalArticle

  382. Diacylglycerol and protein kinase D localization during T lymphocyte activation

    Spitaler, M., Emslie, E., Wood, C. D. & Cantrell, D. 2006 In : Immunity. 24, 5, p. 535-546 12 p.

    Research output: Contribution to journalArticle

  383. A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration

    Ruiz-Alcaraz, A. J., Liu, H-K., Cuthbertson, D. J., McManus, E. J., Akhtar, S., Lipina, C., Morris, A. D., Petrie, J. R., Hundal, H. S. & Sutherland, C. 1 Dec 2005 In : Biochemical Journal. 392, p. 345-352 8 p.

    Research output: Contribution to journalArticle

  384. Generation and characterization of p38beta (MAPK11) gene-targeted mice

    Beardmore, V. A., Hinton, H. J., Eftychi, C., Apostolaki, M., Armaka, M., Darragh, J., McIlrath, J., Carr, J. M., Armit, L. J., Clacher, C., Malone, L., Kollias, G. & Arthur, S. C. Dec 2005 In : Molecular and Cellular Biology. 25, 23, p. 10454-10464 11 p.

    Research output: Contribution to journalArticle

  385. Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle

    Turban, S., Beardmore, V. A., Carr, J. M., Sakamoto, K., Hajduch, E., Arthur, J. S. C. & Hundal, H. S. Nov 2005 In : Diabetes. 54, 11, p. 3161-3168 8 p.

    Research output: Contribution to journalArticle

  386. Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice

    Bayascas, J. R., Leslie, N., Parsons, R., Fleming, S. & Alessi, D. Oct 2005 In : Current Biology. 15, 20, p. 1839-1846 8 p.

    Research output: Contribution to journalArticle

  387. Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

    Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G. & Hardie, D. G. Jul 2005 In : Cell Metabolism. 2, 1, p. 9-19 11 p.

    Research output: Contribution to journalArticle

  388. The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number

    Roper, J. R., Guther, M. L. S., MacRae, J. I., Prescott, A. R., Hallyburton, I., Acosta-Serrano, A. & Ferguson, M. A. J. 20 May 2005 In : Journal of Biological Chemistry. 280, 20, p. 19728-19736 9 p.

    Research output: Contribution to journalArticle

  389. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

    Sakamoto, K., McCarthy, A., Smith, D., Green, K. A., Hardie, D. G., Ashworth, A. & Alessi, D. R. May 2005 In : The EMBO Journal. 24, 10, p. 1810-1820 11 p.

    Research output: Contribution to journalArticle

  390. MSK1 activity is controlled by multiple phosphorylation sites

    McCoy, C. E., Campbell, D. G., Deak, M., Bloomberg, G. B. & Arthur, J. S. C. 15 Apr 2005 In : Biochemical Journal. 387, Pt 2, p. 507-517 11 p.

    Research output: Contribution to journalArticle

  391. Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells

    MacAulay, K., Blair, A. S., Hajduch, E., Terashima, T., Baba, O., Sutherland, C. & Hundal, H. S. 11 Mar 2005 In : Journal of Biological Chemistry. 280, 10, p. 9509-9518 10 p.

    Research output: Contribution to journalArticle

  392. Ceramide down-regulates System A amino acid transport and protein synthesis in rat skeletal muscle cells

    Hyde, R., Hajduch, E., Powell, D. J., Taylor, P. M. & Hundal, H. S. Mar 2005 In : FASEB Journal. 19, 3, p. 461-463 3 p.

    Research output: Contribution to journalArticle

  393. SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway

    Fukuhara, N., Ebert, J., Unterholzner, L., Lindner, D., Izaurralde, E. & Conti, E. 18 Feb 2005 In : Molecular Cell. 17, 4, p. 537-47 11 p.

    Research output: Contribution to journalArticle

  394. Trypanosoma brucei glycoproteins contain novel giant poly-N-acetyllactosamine carbohydrate chains

    Atrih, A., Richardson, J. M., Prescott, A. R. & Ferguson, M. A. J. 14 Jan 2005 In : Journal of Biological Chemistry. 280, 2, p. 865-871 7 p.

    Research output: Contribution to journalArticle

  395. AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

    Rencurel, F., Stenhouse, A., Hawley, S. A., Friedberg, T., Hardie, D. G., Sutherland, C. & Wolf, C. R. 2005 In : Journal of Biological Chemistry. 280, 6, p. 4367-4373 7 p.

    Research output: Contribution to journalArticle

  396. Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3

    Lipina, C., Huang, X., Finlay, D., McManus, E. J., Alessi, D. R. & Sutherland, C. 2005 In : Biochemical Journal. 392, 3, p. 633-639 7 p.

    Research output: Contribution to journalArticle

  397. Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

    Mora, A., Lipina, C., Tronche, F., Sutherland, C. & Alessi, D. R. 2005 In : Biochemical Journal. 385, 3, p. 639-648 10 p.

    Research output: Contribution to journalArticle

  398. Developmental changes in expression of GABAA receptor-channels in rat intrinsic cardiac ganglion neurones

    Fischer, H., Harper, A. A., Anderson, C. R. & Adams, D. J. 2005 In : Journal of Physiology. 564, 2, p. 465-474 10 p.

    Research output: Contribution to journalArticle

  399. Molecular mechanisms of kinetochore capture by spindle microtubules

    Tanaka, K., Mukae, N., Dewar, H., Breugel, M. V., James, E. K., Prescott, A. R., Antony, C. & Tanaka, T. U. 2005 In : Nature. 434, 7036, p. 987-994 8 p.

    Research output: Contribution to journalArticle

  400. Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and K-ATP channel activation

    Mirshamsi, S., Laidlaw, H. A., Ning, K., Anderson, E., Burgess, L. A., Gray, A., Sutherland, C. & Ashford, M. L. J. 6 Dec 2004 In : BMC Neuroscience. 5, p. - 18 p.54

    Research output: Contribution to journalArticle

  401. A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs

    McNeill, H., Knebel, A., Arthur, J. S. C., Cuenda, A. & Cohen, P. 1 Dec 2004 In : Biochemical Journal. 384, Pt 2, p. 391-400 10 p.

    Research output: Contribution to journalArticle

  402. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle

    Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M. & Rennie, M. J. Dec 2004 In : FASEB Journal. 18, 15, p. 422- 424 3 p.

    Research output: Contribution to journalArticle

  403. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay

    Unterholzner, L. & Izaurralde, E. 19 Nov 2004 In : Molecular Cell. 16, 4, p. 587-96 10 p.

    Research output: Contribution to journalArticle

  404. Bidirectional substrate fluxes through the System N (SNAT5) glutamine transporter may determine net glutamine flux in rat liver

    Baird, F. E., Beattie, K. J., Hyde, A. R., Ganapathy, V., Rennie, M. J. & Taylor, P. M. 1 Sep 2004 In : Journal of Physiology. 559, 2, p. 367-381 15 p.

    Research output: Contribution to journalArticle

  405. Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR

    Sakamoto, K., Goransson, O., Hardie, D. G. & Alessi, D. R. Aug 2004 In : American Journal of Physiology, Endocrinology and Metabolism. 287, 2, p. E310-E317

    Research output: Contribution to journalArticle

  406. The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules

    Watts, C. Jul 2004 In : Nature Immunology. 5, 7, p. 685-692 8 p.

    Research output: Contribution to journalScientific review

  407. Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosis

    Hutchins, J. R. A., Moore, W. J., Hood, F. E., Wilson, J. S. J., Andrews, P. D., Swedlow, J. R. & Clarke, P. R. Jun 2004 In : Current Biology. 14, 12, p. 1099-1104 6 p.

    Research output: Contribution to journalArticle

  408. Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex

    Bono, F., Ebert, J., Unterholzner, L., Güttler, T., Izaurralde, E. & Conti, E. Mar 2004 In : EMBO Reports. 5, 3, p. 304-10 7 p.

    Research output: Contribution to journalArticle

  409. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

    Lizcano, J. M., Goransson, O., Toth, R., Deak, M., Morrice, N. A., Boudeau, J., Hawley, S., Udd, L., Makela, T. P., Hardie, D. G. & Alessi, D. R. Feb 2004 In : The EMBO Journal. 23, 4, p. 833-843 11 p.

    Research output: Contribution to journalArticle

  410. CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

    Scott, J. W., Hawley, S. A., Green, K. A., Anis, M., Stewart, G., Scullion, G. A., Norman, D. G. & Hardie, D. G. 2004 In : Journal of Clinical Investigation. 113, 2, p. 274-284 11 p.

    Research output: Contribution to journalArticle

  411. Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling

    West, M., Wallin, R. P. A., Matthews, S., Svensson, H. G., Zaru, R., Ljunggren, H-G., Prescott, A. R. & Watts, C. 2004 In : Science. 305, 5687, p. 1153-1157 5 p.

    Research output: Contribution to journalArticle

  412. Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element

    Finlay, D., Patel, S., Dickson, L. M., Shpiro, N., Marquez, R., Rhodes, C. J. & Sutherland, C. 2004 In : BMC Molecular Biology. 5, p. - 13 p.15

    Research output: Contribution to journalArticle

  413. H+/amino acid transporter 1 (PAT1) is the imino acid carrier: an intestinal nutrient/drug transporter in human and rat

    Anderson, C. M. H., Grenade, D. S., Boll, M., Foltz, M., Wake, K. A., Kennedy, D. J., Munck, L. K., Miyauchi, S., Taylor, P. M., Campbell, F. C., Munck, B. G., Daniel, H., Ganapathy, V. & Thwaites, D. T. 2004 In : Gastroenterology. 127, 5, p. 1410-1422 13 p.

    Research output: Contribution to journalArticle

  414. p14 arf promotes small ubiquitin-like modifier conjugation of Werners helicase

    Woods, Y. L., Xirodimas, D. P., Prescott, A. R., Sparks, A., Lane, D. P. & Saville, M. K. 2004 In : Journal of Biological Chemistry. 279, 48, p. 50157-50166 10 p.

    Research output: Contribution to journalArticle

  415. Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo

    Lambert, J. J. & 23 others Spruce, B. A., Campbell, L. A., McTavish, N., Cooper, M. A., Appleyard, M. V. L., O'Neill, M., Howie, J., Samson, J., Watt, S., Murray, K., McLean, D., Leslie, N. R., Safrany, S. T., Ferguson, M. J., Peters, J. A., Prescott, A. R., Box, G., Hayes, A., Nutley, B., Raynaud, F., Downes, C. P., Thompson, A. M. & Eccles, S. 2004 In : Cancer Research. 64, 1, p. 4875-4886 12 p.

    Research output: Contribution to journalArticle

  416. Deletion of the GPIdeAc gene alters the location and fate of glycosylphosphatidylinositol precursors in Trypanosoma brucei

    Guther, M. L. S., Prescott, A. R. & Ferguson, M. A. J. 16 Dec 2003 In : Biochemistry. 42, 49, p. 14532-14540 9 p.

    Research output: Contribution to journalArticle

  417. Knockout of ERK5 causes multiple defects in placental and embryonic development

    Yan, L., Carr, J., Ashby, P. R., Murray-Tait, V., Thompson, C. & Arthur, J. S. C. 16 Dec 2003 In : BMC Developmental Biology. 3, 21 p.

    Research output: Contribution to journalArticle

  418. Redox regulation of PI 3-kinase signalling via inactivation of PTEN

    Leslie, N., Bennett, D., Downes, P., Gray, A., Lindsay, Y. E. & Stewart, H. Oct 2003 In : EMBO Journal. 22, 20, p. 5501-5510 10 p.

    Research output: Contribution to journalArticle

  419. Complexes between the LKB1 tumor suppressor, STRAD α/β and MO25 α/β are upstream kinases in the AMP-activated protein kinase cascade

    Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Makela, T. P., Alessi, D. R. & Hardie, D. G. Sep 2003 In : Journal of Biology. 2, 4, p. 28 1 p.

    Research output: Contribution to journalArticle

  420. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

    Mora, A., Davies, A. M., Bertrand, L., Sharif, I., Budas, G. R., Jovanovic, S., Mouton, V., Kahn, C. R., Lucocq, J. M., Gray, G. A., Jovanovic, A. & Alessi, D. R. Sep 2003 In : The EMBO Journal. 22, 18, p. 4666-4676 11 p.

    Research output: Contribution to journalArticle

  421. Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex

    Sutherland, C. M., Hawley, S. A., McCartney, R. R., Leech, A., Stark, M. J. R., Schmidt, M. C. & Hardie, D. G. 5 Aug 2003 In : Current Biology. 13, 15, p. 1299-1305 7 p.

    Research output: Contribution to journalArticle

  422. Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways

    Gatfield, D., Unterholzner, L., Ciccarelli, F. D., Bork, P. & Izaurralde, E. 1 Aug 2003 In : EMBO Journal. 22, 15, p. 3960-70 11 p.

    Research output: Contribution to journalArticle

  423. Nuclear speckle localisation of the small heat shock protein αB-crystallin and its inhibition by the R120G cardiomyopathy-linked mutation

    Van Den Ijssel, P., Wheelock, R., Prescott, A., Russell, P. & Quinlan, R. A. Jul 2003 In : Experimental Cell Research. 287, 2, p. 249-261 13 p.

    Research output: Contribution to journalArticle

  424. Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

    Beugnet, A., Tee, A. R., Taylor, P. M. & Proud, C. G. 1 Jun 2003 In : Biochemical Journal. 372, 2, p. 555-566 12 p.

    Research output: Contribution to journalArticle

  425. Knockout of the intermediate filament protein CP49 destabilises the lens fibre cell cytoskeleton and decreases lens optical quality, but does not induce cataract

    Sandilands, A., Prescott, A. R., Wegener, A., Zoltoski, R. K., Hutcheson, A. M., Masaki, S., Kuszak, J. R. & Quinlan, R. A. Mar 2003 In : Experimental Eye Research. 76, 3, p. 385-391 7 p.

    Research output: Contribution to journalArticle

  426. Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts

    Gray, A., Olsson, H., Batty, I., Priganica, L. & Downes, P. Feb 2003 In : Analytical Biochemistry. 313, 2, p. 234-245 12 p.

    Research output: Contribution to journalArticle

  427. A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias

    Hudson, E. R., Pan, D. A., James, J., Lucocq, J. M., Hawley, S. A., Green, K. A., Baba, O., Terashima, T. & Hardie, D. G. 2003 In : Current Biology. 13, 10, p. 861-866 6 p.

    Research output: Contribution to journalArticle

  428. A role for thyroid hormone transporters in transcriptional regulation by thyroid hormone receptors

    Ritchie, J. W. A., Shi, Y. -B., Hayashi, Y., Baird, F. E., Muchekehu, R. W., Christie, G. R. & Taylor, P. M. 2003 In : Molecular Endocrinology. 17, 4, p. 653-661 9 p.

    Research output: Contribution to journalArticle

  429. Amino acid transporters: roles in amino acid sensing and signalling in animal cells

    Hyde, R., Taylor, P. M. & Hundal, H. S. 2003 In : Biochemical Journal. 373, 1, p. 1-18 18 p.

    Research output: Contribution to journalArticle

  430. Asparagine endopeptidase can initiate the removal of the MHC class II invariant chain chaperone

    Manoury, B., Mazzeo, D., Li, D. N., Billson, J., Loak, K., Benaroch, P. & Watts, C. 2003 In : Immunity. 18, 4, p. 489-498 10 p.

    Research output: Contribution to journalArticle

  431. Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism

    Powell, D. J., Hajduch, E., Kular, G. & Hundal, H. S. H. 2003 In : Molecular and Cellular Biology. 23, 21, p. 7794-7808 15 p.

    Research output: Contribution to journalArticle

  432. Different mechanisms are used by insulin to repress three genes that contain a homologous thymine-rich insulin response element

    Patel, S., Lipina, C. & Sutherland, C. 2003 In : FEBS Letters. 549, 1-3, p. 72-76 5 p.

    Research output: Contribution to journalArticle

  433. Loss of Kindlin-1, a human homolog of the Caenorhabditis elegans actin–extracellular-matrix linker protein UNC-112, causes Kindler syndrome

    Siegel, D. H. , Ashton, G. H. S. , Penagos, H. G. , Lee, J. V. , Feiler, H. S. , Wilhelmsen, K. C. , South, A. P. , Smith, F. , Prescott, A. R. , Wessagowit, V. , Oyama, N. , Akiyama, M. , Al Aboud, D. , Al Aboud, K. , Al Githami, A. , Al Hawsawi, K. , Al Ismaily, A. , Al-Suwaid, R. , Atherton, D. J. , Caputo, R. & 22 others Fine, J-D., Frieden, I. J., Fuchs, E., Haber, R. M., Harada, T., Kitajima, Y., Mallory, S. B., Ogawa, H., Sahin, S., Shimizu, H., Suga, Y., Tadini, G., Tsuchiya, K., Wiebe, C. B., Wojnarowska, F., Zaghloul, A. B., Hamada, T., Mallipeddi, R., Eady, R. A. J., McLean, I., McGrath, J. A. & Epstein, E. H. 2003 In : American Journal of Human Genetics. 73, 1, p. 174-187 14 p.

    Research output: Contribution to journalArticle

  434. Mitochondrial remnant organelles of Giardia function in iron-sulphur protein maturation

    Tovar, J., Leon-Avila, G., Sanchez, L. B., Sutak, R., Tachezy, J., van der Giezen, M., Hernandez, M., Muller, M. & Lucocq, J. M. 2003 In : Nature. 426, 6963, p. 172-176 5 p.

    Research output: Contribution to journalArticle

  435. Observation of keratin particles showing fast bidirectional movement colocalized with microtubules

    Liovic, M., Mogensen, M. M., Prescott, A. R. & Lane, E. B. 2003 In : Journal of Cell Science. 116, 8, p. 1417-1427 11 p.

    Research output: Contribution to journalArticle

  436. Regulation of L-leucine transport in rat kidney by dexamethasone and triiodothyronine

    Schwertfeger, M., Pissowotzki, K., Fleck, C. & Taylor, P. M. 2003 In : Amino Acids. 25, 1, p. 75-83 9 p.

    Research output: Contribution to journalArticle

  437. Regulation of renal amino acid (AA) transport by hormones, drugs and xenobiotics - a review

    Fleck, C., Schwertfeger, M. & Taylor, P. M. 2003 In : Amino Acids. 24, 4, p. 347-374 28 p.

    Research output: Contribution to journalArticle

  438. Altered aggregation properties of mutant γ-crystallins cause inherited cataract

    Sandilands, A., Hutcheson, A. M., Long, H. A., Prescott, A. R., Vrensen, G., Loster, J., Klopp, N., Lutz, R. B., Graw, J., Masaki, S., Dobson, C. M., MacPhee, C. E. & Quinlan, R. A. Nov 2002 In : The EMBO Journal. 21, 22, p. 6005-6014 10 p.

    Research output: Contribution to journalArticle

  439. Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain

    Cowling, V., Downward, J. & Martin, S. J. (ed.) Oct 2002 In : Cell Death & Differentiation. 9, 10, p. 1046-1056 11 p.

    Research output: Contribution to journalArticle

  440. A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane

    Cragg, R. A., Christie, G. R., Phillips, S. R., Russi, R. M., Kury, S., Mathers, J. C., Taylor, P. M. & Ford, D. 21 Jun 2002 In : Journal of Biological Chemistry. 277, 25, p. 22789-22797 9 p.

    Research output: Contribution to journalArticle

  441. The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells

    Mogensen, M. M., Tucker, J. B., Mackie, J. B., Prescott, A. R. & Nathke, I. S. 10 Jun 2002 In : Journal of Cell Biology. 157, 6, p. 1041-1048 8 p.

    Research output: Contribution to journalArticle

  442. Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner

    Christie, G. R., Hajduch, E., Hundal, H. S., Proud, C. G. & Taylor, P. M. 22 Mar 2002 In : Journal of Biological Chemistry. 277, 12, p. 9952-9957 6 p.

    Research output: Contribution to journalArticle

  443. Muscarinic receptors mediate phospholipase C-dependent activation of protein kinase B via Ca2+, ErbB3, and phosphoinositide 3-Kinase in 1321N1 astrocytoma cells

    Tang, X., Batty, I. H. & Downes, C. P. Jan 2002 In : Journal of Biological Chemistry. 277, 1, p. 338-344 7 p.

    Research output: Contribution to journalArticle

  444. Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1

    Watt, S. A., Kular, G., Fleming, I. N., Downes, C. P. & Lucocq, J. M. Jan 2002 In : Biochemical Journal. 363, 3, p. 657-666 10 p.

    Research output: Contribution to journalArticle

  445. Complex regulation of thyroid hormone action: multiple opportunities for pharmacological intervention

    Shi, Y-B., Ritchie, J. W. A. & Taylor, P. M. 2002 In : Pharmacology & Therapeutics. 94, 3, p. 235-251 17 p.

    Research output: Contribution to journalScientific review

  446. Delivery of thyroid hormone from plasma membrane to nucleus: a role for the cytoskeleton and/or vesicular trafficking?

    Muchekehu, R. W. & Taylor, P. M. 2002 In : Journal of Physiology. 544, p. 117P-117P 1 p.S029

    Research output: Contribution to journalMeeting abstract

  447. Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP

    Manoury, B., Mazzeo, D., Fugger, L., Viner, N., Ponsford, M., Streeter, H., Mazza, G., Wraith, D. C. & Watts, C. 2002 In : Nature Immunology. 3, 2, p. 169-174 6 p.

    Research output: Contribution to journalArticle

  448. Inhibition of autophagy in mitotic animal cells

    Eskelinen, E-L., Prescott, A. R., Cooper, J., Brachmann, S. M., Wang, L., Tang, X., Backer, J. M. & Lucocq, J. M. 2002 In : Traffic. 3, 12, p. 878-893 16 p.

    Research output: Contribution to journalArticle

  449. Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

    Rena, G., Woods, Y. L., Prescott, A. R., Peggie, M., Unterman, T. G., Williams, M. R. & Cohen, P. 2002 In : The EMBO Journal. 21, 9, p. 2263-2271 9 p.

    Research output: Contribution to journalArticle

  450. Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblasts

    Dourdin, N., Bhatt, A. K., Dutt, P., Greer, P. A., Arthur, J. S. C., Elce, J. S. & Huttenlocher, A. 21 Dec 2001 In : Journal of Biological Chemistry. 276, 51, p. 48382-48388 7 p.

    Research output: Contribution to journalArticle

  451. Role of the System L permease LAT1 in amino acid and iodothyronine transport in placenta

    Ritchie, J. W. A. & Taylor, P. M. 15 Jun 2001 In : Biochemical Journal. 356, 3, p. 719-725 7 p.

    Research output: Contribution to journalArticle

  452. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent protein kinase, but not its farnesylation at Cys433, is essential for LKB1 to suppress cell growth

    Sapkota, G. P., Kieloch, A., Lizcano, J. M., Lain, S., Arthur, J. . S. C., Williams, M. R., Morrice, N., Deak, M. & Alessi, D. R. 1 Jun 2001 In : Journal of Biological Chemistry. 276, 22, p. 19469-19482 14 p.

    Research output: Contribution to journalArticle

  453. Evidence for prebudding arrest of ER export in animal cell mitosis and its role in generating Golgi partitioning intermediates

    Prescott, A. R., Farmaki, T., Thomson, C., James, J., Paccaud, J-P., Tang, B-L., Hong, W., Quinn, M., Ponnambalam, S. & Lucocq, J. May 2001 In : Traffic. 2, 5, p. 321-335 15 p.

    Research output: Contribution to journalArticle

  454. An essential role for calmodulin in regulating human T cell aggregation

    Fagerholm, S. C., Prescott, A., Cohen, P., Gahmberg, C. G. & Lehto, V-P. (ed.) 28 Feb 2001 In : FEBS Letters. 491, 1-2, p. 131-6 6 p.

    Research output: Contribution to journalArticle

  455. Developmental changes in hyperpolarization-activated currents I(h) and I(K(IR)) in isolated rat intracardiac neurons

    Hogg, R. C., Harper, A. A. & Adams, D. J. 2001 In : Journal of Neurophysiology. 86, 1, p. 312-320 9 p.

    Research output: Contribution to journalArticle

  456. Effect of hypothyroidism on pathways for iodothyronine and tryptophan uptake into rat adipocytes

    Ritchie, J. W. A., Collingwood, C. J. F. & Taylor, P. M. 2001 In : American Journal of Physiology, Endocrinology and Metabolism. 280, 2, p. E254-E259 6 p.

    Research output: Contribution to journalArticle

  457. Mechanisms of glutamine transport in rat adipocytes and acute regulation by cell swelling

    Ritchie, J. W. A., Baird, F. E., Christie, G. R., Stewart, A., Low, S. Y., Hundal, H. S. & Taylor, P. M. 2001 In : Cellular Physiology and Biochemistry. 11, 5, p. 259-270 12 p.

    Research output: Contribution to journalArticle

  458. Neutral amino acid transport via system L at the basolateral membrane of human intestinal Caco-2 cell monolayers

    McCloy, L. R. R., Taylor, P. M. & Thwaites, D. T. 2001 In : Journal of Physiology. 535, p. 48P-49P 2 p.S036

    Research output: Contribution to journalMeeting abstract

  459. Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

    Rena, G., Prescott, A. R., Guo, S., Cohen, P. & Unterman, T. G. 2001 In : Biochemical Journal. 354, 3, p. 605-612 8 p.

    Research output: Contribution to journalArticle

  460. The trigger to cell death determines the efficiency with which dying cells are cleared by neighbours

    Wiegand, U. K., Corbach, S., Prescott, A. R., Savill, J. & Spruce, B. A. 2001 In : Cell Death & Differentiation. 8, 7, p. 734-746 13 p.

    Research output: Contribution to journalArticle

  461. TPIP: a novel phosphoinositide 3-phosphatase

    Walker, S., Downes, P. & Leslie, N. 2001 In : Biochemical Journal. 360, 2, p. 277-283 7 p.

    Research output: Contribution to journalArticle

  462. Verapamil block of large-conductance Ca-activated K channels in rat aortic myocytes

    Harper, A. A., Catacuzzeno, L., Trequattrini, C., Petris, A. & Franciolini, F. 2001 In : Journal of Membrane Biology. 179, 2, p. 103-111 9 p.

    Research output: Contribution to journalArticle

  463. MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells

    Arthur, J. S. C. & Cohen, P. 29 Sep 2000 In : FEBS Letters. 482, 1-2, p. 44-48 5 p.

    Research output: Contribution to journalArticle

  464. Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division

    Arthur, J. S. C., Elce, J. S., Hegadorn, C., Williams, K. & Greer, P. A. Jun 2000 In : Molecular and Cellular Biology. 20, 12, p. 4474-4481 8 p.

    Research output: Contribution to journalArticle

  465. 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase

    Lochhead, P. A., Salt, I. P., Walker, K. S., Hardie, D. G. & Sutherland, C. 2000 In : Diabetes. 49, 6, p. 896-903 8 p.

    Research output: Contribution to journalArticle

  466. Fluorescence measurements of Ca2+ binding to domain VI of calpain

    Arthur, J. S. C. & Elce, J. S. 2000 Calpain Methods and Protocols. Elce, J. S. (ed.). Part II ed. Totowa, New Jersey: Humana Press, p. 121-127 7 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  467. Structure of the mouse calpain small subunit gene

    Arthur, J. S. C., Greer, P. A. & Elce, J. S. 14 Oct 1998 In : Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology. 1388, 1, p. 247-252 6 p.

    Research output: Contribution to journalArticle

  468. The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?

    Hardie, D. G., Carling, D. & Carlson, M. Jul 1998 In : Annual Review of Biochemistry. 67, p. 821-855 35 p.

    Research output: Contribution to journalScientific review

  469. Structural characterisation of two forms of procyclic acidic repetitive protein expressed by procyclic forms of Trypanosoma brucei

    Treumann, A., Zitzmann, N., Hulsmeier, A., Prescott, A. R., Almond, A., Sheehan, J. & Ferguson, M. A. J. 20 Jun 1997 In : Journal of Molecular Biology. 269, 4, p. 529-547 19 p.

    Research output: Contribution to journalArticle

  470. Autolysis, Ca2+ requirement, and heterodimer stability in m-calpain

    Elce, J. S., Hegadorn, C. & Arthur, J. S. C. 25 Apr 1997 In : Journal of Biological Chemistry. 272, 17, p. 11268-11275 8 p.

    Research output: Contribution to journalArticle

  471. The prohibitin family of mitochondrial proteins regulate replicative lifespan

    Coates, P. J., Jamieson, D. J., Smart, K., Prescott, A. R. & Hall, P. A. 1997 In : Current Biology. 7, 8, p. 607-610 4 p.

    Research output: Contribution to journalArticle

  472. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

    Hawley, S. A., Davison, M., Woods, A., Davies, S. P., Beri, R. K., Carling, D. & Hardie, D. G. 1 Nov 1996 In : Journal of Biological Chemistry. 271, 44, p. 27879-27887 9 p.

    Research output: Contribution to journalArticle

  473. Interaction of aspartic acid-104 and proline-287 with the active site of m-calpain

    Arthur, J. S. C. & Elce, J. S. 15 Oct 1996 In : Biochemical Journal. 319, (Pt2), p. 535-541 7 p.

    Research output: Contribution to journalArticle

  474. An immunocytochemical study of the carbonic anhydrase I isoenzyme in human oral Merkel cells

    Christie, K. N., Thomson, C., Hopwood, D., Harper, A. A. & Ogden, G. R. 1996 In : Archives of Oral Biology. 41, 8-9, p. 901-904 4 p.

    Research output: Contribution to journalArticle

  475. Mutations which block the binding of calmodulin to Spc110p cause multiple mitotic defects

    Stirling, D. A., Rayner, T. F., Prescott, A. R. & Stark, M. J. R. 1996 In : Journal of Cell Science. 109, p. 1297-1310 14 p.

    Research output: Contribution to journalArticle

  476. Active site residues in m-calpain: identification by site-directed mutagenesis

    Arthur, J. S. C., Gauthier, S. & Elce, J. S. 24 Jul 1995 In : FEBS Letters. 368, 3, p. 397-400 4 p.

    Research output: Contribution to journalArticle

  477. Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1

    Kearsey, J. M., Coates, P. J., Prescott, A. R., Warbrick, E. & Hall, P. A. 1995 In : Oncogene. 11, 9, p. 1675-1683 9 p.

    Research output: Contribution to journalArticle

  478. The CL100 gene, which encodes a dual specificity (Tyr/Thr) MAP kinase phosphatase, is highly conserved and maps to human chromosome 5q34

    Emslie, E. A., Jones, T. A., Sheer, D. & Keyse, S. M. 1994 In : Human Genetics. 93, 5, p. 513-6 4 p.

    Research output: Contribution to journalArticle

  479. Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

    Keyse, S. M. & Emslie, E. A. 1992 In : Nature. 359, 6396, p. 644-7 4 p.

    Research output: Contribution to journalArticle

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