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Clinical Pharmacology & Therapeutics

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  1. Improving the cost-effectiveness of photographic screening for diabetic macular oedema: a prospective, multi-centre, UK study

    Prescott, G., Sharp, P., Goatman, K., Scotland, G., Fleming, A., Philip, S., Staff, R., Santiago, C., Borooah, S., Broadbent, D., Chong, V., Dodson, P., Harding, S., Leese, G., Megaw, R., Styles, C., Swa, K., Wharton, H. & Olson, J. Aug 2014 In : British Journal of Ophthalmology. 98, 8, p. 1042-1049 8 p.

    Research output: Contribution to journalArticle

  2. Proteomic and genomic studies of non-alcoholic fatty liver disease - clues in the pathogenesis

    Lim, J. W., Dillon, J. & Miller, M. 14 Jul 2014 In : World Journal of Gastroenterology . 20, 26, p. 8325-8340 16 p.

    Research output: Contribution to journalArticle

  3. Intergenerational transmission of postpartum haemorrhage risk: analysis of two Scottish birth cohorts

    Sharp, G. C., Saunders, P. T. K., Greene, S. A., Morris, A. D. & Norman, J. E. Jul 2014 In : American Journal of Obstetrics and Gynecology. 211, 1, p. 51.e1-51.e7 7 p.

    Research output: Contribution to journalArticle

  4. Thrombocytosis is associated with increased short and long term mortality after exacerbation of chronic obstructive pulmonary disease: a role for antiplatelet therapy?

    Harrison, M. T., Short, P., Williamson, P. A., Singanayagam, A., Chalmers, J. D. & Schembri, S. Jul 2014 In : Thorax. 69, 7, p. 609-615 7 p.

    Research output: Contribution to journalArticle

  5. Targeted genetic testing for familial hypercholesterolaemia using next generation sequencing: a population-based study

    Norsworthy, P. J., Vandrovcova, J., Thomas, E. R. A., Campbell, A., Kerr, S. M., Biggs, J., Game, L., Soutar, A. K., Smith, B. H., Dominiczak, A. F., Porteous, D. J., Morris, A. D., Generation Scotland & Aitman, T. J. 23 Jun 2014 In : BMC Medical Genetics. 15, 7 p.70

    Research output: Contribution to journalArticle

  6. Effectiveness of newspaper advertising for patient recruitment into a clinical trial

    Hapca, A., Jennings, C. G., Wei, L., Wilson, A., MacDonald, T. M. & Mackenzie, I. S. Jun 2014 In : British Journal of Clinical Pharmacology. 77, 6, p. 1064-1072 9 p.

    Research output: Contribution to journalArticle

  7. Factors associated with statin treatment for the primary prevention of cardiovascular disease in people within 2 years following diagnosis of diabetes in Scotland, 2006-2008

    Jones, N. R. V., Fischbacher, C. M., Guthrie, B., Leese, G., Lindsay, R. S., McKnight, J. A., Pearson, D., Philip, S., Sattar, N., Wild, S. H. & Scottish Diabetes Research Network Epidemiology Group Jun 2014 In : Diabetic Medicine. 31, 6, p. 640-646 7 p.

    Research output: Contribution to journalArticle

  8. Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis

    Zhou, K., Donnelly, L., Yang, J., Li, M., Deshmukh, H., Van Zuydam, N., Ahlqvist, E., Spencer, C. C., Groop, L., Morris, A. D., Colhoun, H. M., Sham, P. C., McCarthy, M. I., Palmer, C. N. A. & Pearson, E. R. Jun 2014 In : The Lancet Diabetes and Endocrinology. 2, 6, p. 481-487 7 p.

    Research output: Contribution to journalArticle

  9. Review article: 2014 UK consensus guidelines - hepatitis C management and direct-acting anti-viral therapy

    Miller, M. H., Agarwal, K., Austin, A., Brown, A., Barclay, S. T., Dundas, P., Dusheiko, G. M., Foster, G. R., Fox, R., Hayes, P. C., Leen, C., Millson, C., Ryder, S. D., Tait, J., Ustianowski, A. & Dillon, J. F. Jun 2014 In : Alimentary Pharmacology & Therapeutics. 39, 12, p. 1363-1375 13 p.

    Research output: Contribution to journalArticle

  10. A world without hepatitis C

    Ryder, S. & Dillon, J. 9 May 2014 In : Health Service Journal. 124, 6397, p. 21-23 3 p.

    Research output: Contribution to journalArticle

  11. A gender-sensitised weight loss and healthy living programme for overweight and obese men delivered by Scottish Premier League football clubs (FFIT): a pragmatic randomised controlled trial

    Hunt, K., Wyke, S., Gray, C. M., Anderson, A. S., Brady, A., Bunn, C., Donnan, P. T., Fenwick, E., Grieve, E., Lieshman, J., Miller, E., Mutrie, N., Rauchhaus, P., White, A. & Treweek, S. 5 Apr 2014 In : Lancet. 383, 9924, p. 1211-1221 11 p.

    Research output: Contribution to journalArticle

  12. A New Technique Using Fibrin Glue in the Management of Auricular Hematoma

    Mohamad, S. H., Barnes, M., Jones, S. & Mahendran, S. 2 Apr 2014 In : Clinical Journal of Sport Medicine.

    Research output: Contribution to journalArticle

  13. Cholesteryl ester transfer protein polymorphisms, statin use, and their impact on cholesterol levels and cardiovascular events

    Morris, A. D. & 23 others Leusink, M., Onland-Moret, N. C., Asselbergs, F. W., Ding, B., Kotti, S., van Zuydam, N. R., Papp, A. C., Danchin, N., Donnelly, L., Chasman, D. I., Doevendans, P. A. F. M., Klungel, O. H., Ridker, P. M., van Gilst, W. H., Simon, T., Nyberg, F., Palmer, C. N. A., Sadee, W., van der Harst, P., de Bakker, P. I. W., de Boer, A., Verstuyft, C. & Maitland-van der Zee, A. H. Mar 2014 In : Clinical Pharmacology & Therapeutics. 95, 3, p. 314-320 7 p.

    Research output: Contribution to journalArticle

  14. The impact of age and chronic kidney disease on secondary prevention post-primary percutaneous coronary intervention

    Zachariah, D., Brown, R., Kanagala, P., Bashir, A., Mohan, M., Callan, P., Rajendra, R., Clark, A. L., Squire, I., Gunning, M., Lang, C. C. & Kalra, P. R. Mar 2014 In : QJM : an International Journal of Medicine. 107, 3, p. 185-192

    Research output: Contribution to journalArticle

  15. The Kuwait-Scotland eHealth Innovation Network (KSeHIN): a sustainable approach to quality improvement in healthcare

    Conway, N. T. , Connell, J. , Morris, A. & 21 others Wotayan, R. A., Alkuzam, A., Al-Refaei, F. F., Badawi, D., Barake, R., Bell, A., Boyle, G., Chisholm, S., Emslie-Smith, A., Goddard, C. A., Greene, S. A., Halawa, N., Judson, A., Kelly, C., Ker, J., Scott, M., Shaltout, A., Sukkar, F., Wake, D., Sibbald, D. & Behbehani, K. Feb 2014 In : Quality in Primary Care. 22, 1, p. 43-51 9 p.

    Research output: Contribution to journalArticle

  16. A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain

    Meng, W., Deshmukh, H. A., van Zuydam, N. R., Liu, Y., Donnelly, L. A., Zhou, K., Morris, A. D., Colhoun, H. M., Palmer, C. N. A., Smith, B. H., Wellcome Trust Case Control Consortium 2 (WTCCC2) & Surrogate Markers for Micro- and Macro-Vascular Hard Endpoints for Innovative Diabetes Tools (SUMMIT) Study Group 2014 In : European Journal of Pain.

    Research output: Contribution to journalArticle

  17. Association of day length and weather conditions with physical activity levels in older community dwelling people

    Witham, M. D., Donnan, P. T., Vadiveloo, T., Sniehotta, F. F., Crombie, I. K., Feng, Z. & McMurdo, M. E. T. 2014 In : PLoS ONE. 9, 1, e85331

    Research output: Contribution to journalArticle

  18. Clinical trial design for older people - time for a rethink

    Witham, M. D. & George, J. 2014 In : QJM : an International Journal of Medicine. 107, 1, p. 15-16 2 p.

    Research output: Contribution to journalArticle

  19. Common carotid intima media thickness and ankle-brachial pressure index correlate with local but not global atheroma burden: a cross sectional study using whole body magnetic resonance angiography

    Weir-McCall, J. R., Khan, F., Lambert, M. A., Adamson, C. L., Gardner, M., Gandy, S. J., Ramkumar, P. G., Belch, J. J. F., Struthers, A. D., Rauchhaus, P., Morris, A. D. & Houston, J. G. 2014 In : PLoS ONE. 9, 6, p. e99190

    Research output: Contribution to journalArticle

  20. Drugs that interact with levothyroxine: an observational study from the Thyroid Epidemiology, Audit and Research Study (TEARS)

    Irving, S. N., Vadiveloo, T. & Leese, G. P. 2014 In : Clinical Endocrinology. 11 p.

    Research output: Contribution to journalArticle

  21. End stage renal disease and survival in people with diabetes: a national database linkage study

    Bell, S., Fletcher, E. H., Brady, I., Looker, H. C., Levin, D., Joss, N., Traynor, J. P., Metcalfe, W., Conway, B., Livingstone, S., Leese, G., Philip, S., Wild, S., Halbesma, N., Sattar, N., Lindsay, R. S., McKnight, J., Pearson, D., Colhoun, H. M. & On behalf of the Scottish Diabetes Research Network and Scottish Renal Registry 2014 In : QJM : an International Journal of Medicine. 21 p.

    Research output: Contribution to journalArticle

  22. High-potency statin and ezetimibe use and mortality in survivors of an acute myocardial infarction: a population-based study

    Pauriah, M., Elder, D. H. J., Ogston, S., Noman, A. Y. S., Majeed, A., Wyatt, J. C., Choy, A-M., MacDonald, T. M., Struthers, A. D. & Lang, C. C. 2014 In : Heart. 100, 11, p. 867-872 6 p.

    Research output: Contribution to journalArticle

  23. Influence of β2-adrenoceptor 16 genotype on propranolol-induced bronchoconstriction in patients with persistent asthma

    Anderson, W. J., Short, P. M., Manoharan, A., Lipworth, J. L. R. & Lipworth, B. J. 2014 In : Annals of Allergy, Asthma & Immunology. 112, 5, p. 475-476 2 p.

    Research output: Contribution to journalLetter

  24. Invasive pulmonary aspergillosis post extracorporeal membrane oxygenation support and literature review

    Parcell, B. J., Raju, P. K. B. C., Johnson, E. M., Fardon, T. C. & Olver, W. J. 2014 In : Medical Mycology Case Reports. 4, April - June, p. 12-15 4 p.

    Research output: Contribution to journalArticle

  25. Patient-important benefits of clearing the hepatitis C virus through treatment: a simulation model

    Innes, H., Goldberg, D., Dusheiko, G., Hayes, P., Mills, P. R., Dillon, J. F., Aspinall, E., Barclay, S. T. & Hutchinson, S. J. 2014 In : Journal of Hepatology. 60, 6, p. 1118-1126 9 p.

    Research output: Contribution to journalArticle

  26. Promoting family-focused approaches within adult drug services: the potential of the 'Senses Framework'

    Orr, L. C., Elliott, L. & Barbour, R. S. 2014 In : International Journal of Drug Policy. 9 p.

    Research output: Contribution to journalArticle

  27. Protocol of the Febuxostat versus Allopurinol Streamlined Trial (FAST): a large prospective, randomised, open, blinded endpoint study comparing the cardiovascular safety of allopurinol and febuxostat in the management of symptomatic hyperuricaemia

    MacDonald, T. M., Ford, I., Nuki, G., Mackenzie, I. S., De Caterina, R., Findlay, E., Hallas, J., Hawkey, C. J., Ralston, S., Walters, M., Webster, J., McMurray, J., Perez Ruiz, F. & Jennings, C. G. 2014 In : BMJ Open. 4, 7, e005354

    Research output: Contribution to journalArticle

  28. Rates of referable eye disease in the Scottish National Diabetic Retinopathy Screening Programme

    on behalf of the Scottish Diabetes Research Network Epidemiology Group and the Scottish Diabetic Retinopathy Collaborative 2014 In : British Journal of Ophthalmology. 98, 6, p. 790-795 6 p.

    Research output: Contribution to journalArticle

  29. Small airway dysfunction is associated with poorer asthma control

    Manoharan, A., Anderson, W. J., Lipworth, J., Ibrahim, I. & Lipworth, B. J. 2014 In : European Respiratory Journal.

    Research output: Contribution to journalArticle

  30. Tadalafil in patients with chronic obstructive pulmonary disease: a randomised, double-blind, parallel-group, placebo-controlled trial

    Goudie, A. R., Lipworth, B. J., Hopkinson, P. J., Wei, L. & Struthers, A. D. 2014 In : The Lancet Respiratory Medicine. 2, 4, p. 293-300 8 p.

    Research output: Contribution to journalArticle

  31. The impact of Scottish Government protocols on practice in Scotland

    Steele, P. R. C., Barnes, M. L. & Ross, P. D. 2014 In : Journal of Laryngology and Otology. 128, 4, p. 345-349 5 p.

    Research output: Contribution to journalArticle

  32. The source of BNP in rheumatoid arthritis

    George, J., Khan, F. & Struthers, A. D. 2014 In : International Journal of Cardiology. 174, 3, p. 740 1 p.

    Research output: Contribution to journalArticle

  33. Unlocking the quiet zone: the small airway asthma phenotype

    Lipworth, B., Manoharan, A. & Anderson, W. 2014 In : The Lancet Respiratory Medicine. 2, 6, p. 497-506 10 p.

    Research output: Contribution to journalArticle

  34. Myocardial fibrosis and QTc are reduced following treatment with spironolactone or amiloride in stroke survivors: a randomised placebo-controlled cross-over trial

    Wong, K. Y. K., Wong, S. Y. S., McSwiggan, S., Ogston, S. A., Sze, K. Y. S., MacWalter, R. S. & Struthers, A. D. 15 Oct 2013 In : International Journal of Cardiology. 168, 6, p. 5229-5233

    Research output: Contribution to journalArticle

  35. Self-monitoring of blood glucose in type 2 diabetes: patients' perceptions of 'high' readings

    Evans, J. M. M., Mackison, D., Swanson, V., Donnan, P. T., Emslie-Smith, A. & Lawton, J. Oct 2013 In : Diabetes Research and Clinical Practice. 102, 1, p. e5-e7

    Research output: Contribution to journalArticle

  36. Carer involvement with drug services: a qualitative study

    Orr, L. C., Barbour, R. S. & Elliott, L. Sep 2013 In : Health Expectations. 16, 3, p. e60-e72 13 p.

    Research output: Contribution to journalArticle

  37. Association of DISC1 variants with age of onset in a population-based sample of recurrent major depression

    Thomson, P. A., MacIntyre, D. J., Hamilton, G., Dominiczak, A., Smith, B. H., Morris, A., Evans, K. L. & Porteous, D. J. Jul 2013 In : Molecular Psychiatry. 18, 7, p. 745-747 3 p.

    Research output: Contribution to journalLetter

  38. Estimated GFR reporting is associated with decreased nonsteroidal anti-inflammatory drug prescribing and increased renal function

    Wei, L., MacDonald, T. M., Jennings, C., Sheng, X., Flynn, R. W. & Murphy, M. J. Jul 2013 In : Kidney International. 84, 1, p. 174-178 5 p.

    Research output: Contribution to journalArticle

  39. An ethnographic exploration of influences on prescribing in general practice: why is there variation in prescribing practices?

    Grant, A., Sullivan, F. & Dowell, J. 21 Jun 2013 In : Implementation Science. 8, 14 p.72

    Research output: Contribution to journalArticle

  40. Randomised Placebo-controlled Trial to Evaluate Chronic Dosing Effects of Propranolol in Asthma

    Short, P. M., Williamson, P. A., Anderson, W. J. & Lipworth, B. J. 15 Jun 2013 In : American Journal of Respiratory and Critical Care Medicine. 187, 12, p. 1308-1314 7 p.

    Research output: Contribution to journalArticle

  41. Oesophageal bacterial biofilm changes in gastro-oesophageal reflux disease, Barrett's and oesophageal carcinoma: association or causality?

    Blackett, K. L., Siddhi, S. S., Cleary, S., Steed, H., Miller, M. H., Macfarlane, S., Macfarlane, G. T. & Dillon, J. F. Jun 2013 In : Alimentary Pharmacology & Therapeutics. 37, 11, p. 1084-1092 9 p.

    Research output: Contribution to journalArticle

  42. Role of endothelium-derived hyperpolarising factor in acetylcholine-mediated vasodilatation in skin

    Newton, D. J., Davies, J., Belch, J. J. F. & Khan, F. Jun 2013 In : International Angiology. 32, 3, p. 312-318 7 p.

    Research output: Contribution to journalArticle

  43. The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

    Morris, A. D. & 124 others Fall, T., Hägg, S., Mägi, R., Ploner, A., Fischer, K., Horikoshi, M., Sarin, A-P., Thorleifson , . G., Ladenvall, C., Kals, M., Kuningas, M., Draisma, H. H. M., Reid, J. S., van Zuydam, N. R., Huikari, V., Mangino, M., Sonestedt, E., Benyamin, B., Nelson, C. P., Rivera, N. V., Kristiansson, K., Shen, H., Havulinna, A. S., Dehghan, A., Donnelly, L. A., Kaakinen, M., Nuotio, M-L., Robertson, N., de Bruijn, R. F. A. G., Ikram, M. A., Amin, N., Balmforth, A. J., Braund, P. S., Doney, A. S. F., Doring, A., Elliott, P., Esko, T., Franco, O. H., Gretarsdottir, S., Hartikainen, A-L., Heikkila, K., Herzig, K-H., Holm, H., Hottenga, J. J., Hypponen, E., Illig, T., Isaacs, A., Isomaa, B., Karssen, L. C., Kettunen, J., Koenig, W., Kuulasmaa, K., Laatikainen, T., Laitinen, J., Lindgren, C., Lyssenko, V., Laara, E., Rayner, N. W., Mannisto, S., Pouta, A., Rathmann, W., Rivadeneira, F., Ruokonen, A., Savolainen, M. J., Sijbrands, E. J. G., Small, K. S., Smit, J. H., Steinthorsdottir, V., Syvanen, A-C., Taanila, A., Tobin, M. D., Uitterlinden, A. G., Willems, S. M., Willemsen, G., Witteman, J., Perola, M., Evans, A., Ferrieres, J., Virtamo, J., Kee, F., Tregouet, D-A., Arveiler, D., Amouyel, P., Ferrario, M. M., Brambilla, P., Hall, A. S., Heath, A. C., Madden, P. A. F., Martin, N. G., Montgomery, G. W., Whitfield, J. B., Jula, A., Knekt, P., Oostra, B. A., van Duijn, C. M., Penninx, B. W. J. H., Davey Smith, G., Kaprio, J., Samani, N. J., Gieger, C., Peters, A., Wichmann, H-E., Boomsma, D. I., de Geus, E. J. C., Tuomi, T., Power, C., Hammond, C. J., Spector, T. D., Lind, L., Orho-Melander, M., Palmer, C. N. A., Groop, L., Jarvelin, M-R., Salomaa, V., Vartiainen, E., Hofman, A., Ripatti, S., Metspalu, A., Thorsteinsdottir, U., Stefansson, K., Pedersen, N. L., McCarthy, M. I., Ingelsson, E. & Prokopenko, I. Jun 2013 In : PLoS Medicine. 10, 6, e1001474

    Research output: Contribution to journalArticle

  44. Commentary: vancomycin or metronidazole in patients with primary sclerosing cholangitis?

    Paterson, J. C. M. & Dillon, J. F. May 2013 In : Alimentary Pharmacology & Therapeutics. 37, 9, p. 915 1 p.

    Research output: Contribution to journalComment/debate

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