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College of Life Sciences

  1. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status

    Cameron, A. R., Morrison, V., Levin, D., Mohan, M., Forteath, C., Beall, C., McNeilly, A. D., Balfour, D. J., Savinko, T., Wong, A. K., Viollet, B., Sakamoto, K., Fagerholm, S. C., Foretz, M., Lang, C. C. & Rena, G. 14 Jul 2016 In : Circulation Research.

    Research output: Contribution to journalArticle

  2. The European Union's investment and future role in dermatologic research

    Leigh, I. M. Jul 2016 In : Journal of Investigative Dermatology. 136, 7, p. 1307-1310 4 p.

    Research output: Contribution to journalEditorial

  3. The genome of the yellow potato cyst nematode Globodera rostochiensis reveals insights into the basis of parasitism and virulence

    Eves-van den Akker, S. , Laetsch, D. R. , Thorpe, P. , Lilley, C. J. , Danchin, E. G. J. , Da Rocha, M. , Rancurel, C. , Holroyd, N. E. , Cotton, J. , Szitenberg, A. , Grenier, E. , Montarry, J. , Mimee, B. , Duceppe, M-O. , Boyes, I. , Marvin, J. M. C. , Jones, L. M. , Yusup, H. B. , Lafond-Lapalme, J. & 15 others Esquibet, M., Sabeh, M., Rott, M., Overmars, H., Finkers-Tomczak, A., Smant, G., Koutsovoulos, G., Blok, V., Mantelin, S., Cock, P. J. A., Phillips, W., Henrissat, B., Urwin, P. E., Blaxter, M. & Jones, J. T. 10 Jun 2016 In : Genome Biology. 17, 23 p., 124

    Research output: Contribution to journalArticle

  4. Structural mechanisms of voltage sensing in G protein coupled receptors

    Vickery, O. N., Machtens, J-P., Tamburrino, G., Seeliger, D. & Zachariae, U. 7 Jun 2016 In : Structure. 24, 6, p. 997-1007 11 p.

    Research output: Contribution to journalArticle

  5. Combined changes in Wnt signalling response and contact inhibition induce altered proliferation in radiation treated intestinal crypts

    Dunn, S. J., Osborne, J., Appleton, P. L. & Näthke, I. 1 Jun 2016 In : Molecular Biology of the Cell. 27, 11, p. 1863-1874 12 p.

    Research output: Contribution to journalArticle

  6. Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes

    Hügle, M., Lucas, X., Weitzel, G., Ostrovskyi, D., Breit, B., Gerhardt, S., Schmidtkunz, K., Jung, M., Schüle, R., Einsle, O., Günther, S. & Wohlwend, D. 1 Jun 2016 In : Data in Brief. 7, p. 1370-1374 5 p.

    Research output: Contribution to journalArticle

  7. Glycoproteomic studies of IgE from a novel hyper IgE syndrome linked to PGM3 mutation

    Wu, G., Hitchen, P. G., Panico, M., North, S. J., Barbouche, M-R., Binet, D., Morris, H. R., Dell, A. & Haslam, S. M. Jun 2016 In : Glycoconjugate Journal. 33, 3, p. 447-456 10 p.

    Research output: Contribution to journalArticle

  8. Erythematous nodes, urticarial rash and arthralgias in a large pedigree with NLRC4-related autoinflammatory disease, expansion of the phenotype

    Volker-Touw, C. M. L., de Koning, H. D., Giltay, J., de Kovel, C., van Kempen, T. S., Oberndorff, K., Boes, M., van Steensel, M. A. M., van Well, G. T. J., Blokx, W. A. M., Schalkwijk, J., Simon, A., Frenkel, J. & van Gijn, M. E. 20 May 2016 In : British Journal of Dermatology.

    Research output: Contribution to journalArticle

  9. AMPK Causes Cell Cycle Arrest in LKB1-deficient Cells via Activation of CAMKK2

    Fogarty, S., Ross, F. A., Vara Ciruelos, D., Gray, A., Gowans, G. J. & Hardie, D. G. 2 May 2016 In : Molecular Cancer Research.

    Research output: Contribution to journalArticle

  10. Iron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD

    Watson, A., Lipina, C., McArdle, H. J., Taylor, P. M. & Hundal, H. May 2016 In : Cellular Signalling. 28, 5, p. 412-424

    Research output: Contribution to journalArticle

  11. The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

    Hoxhaj, G., Caddye, E., Najafov, A., Houde, V. P., Johnson, C., Dissanayake, K., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 22 Apr 2016 In : eLife. 5, e12278

    Research output: Contribution to journalArticle

  12. Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling

    Zhou, Z., Tang, A. T., Wong, W. Y., Bamezai, S., Goddard, L. M., Shenkar, R., Zhou, S., Yang, J., Wright, A. C., Foley, M., Arthur, J. S. C., Whitehead, K. J., Awad, I. A., Li, D. Y., Zheng, X. & Kahn, M. L. 7 Apr 2016 In : Nature. 532, 7597, p. 122-126 5 p., 17178

    Research output: Contribution to journalArticle

  13. Direct non transcriptional role of NF-Y in DNA replication

    Benatti, P., Belluti, S., Miotto, B., Neusiedler, J., Dolfini, D., Drac, M., Basile, V., Schwob, E., Mantovani, R., Blow, J. J. & Imbriano, C. 1 Apr 2016 In : Biochimica et Biophysica Acta. Molecular Cell Research. 1863, 4, p. 673-685 13 p.

    Research output: Contribution to journalArticle

  14. The chromatin remodelling enzymes SNF2H and SNF2L position nucleosomes adjacent to CTCF and other transcription

    Wiechens, N., Singh, V., Gkikopoulos, T., Schofield, P., Rocha, S. & Owen-Hughes, T. 28 Mar 2016 In : PLoS Genetics.

    Research output: Contribution to journalArticle

  15. A Trapped Covalent Intermediate of a Glycoside Hydrolase on the Pathway to Transglycosylation. Insights from Experiments and Quantum Mechanics/Molecular Mechanics Simulations

    Raich, L., Borodkin, V., Fang, W., Castro-Lopez, J., van Aalten, D. M. F., Hurtado-Guerrero, R. & Rovira, C. 16 Mar 2016 In : Journal of the American Chemical Society. 138, 10, p. 3325-3332 8 p.

    Research output: Contribution to journalArticle

  16. Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in fan1 nuclease-defective knock-in mice

    Lachaud, C., Slean, M., Marchesi, F., Lock, C., Odell, E., Castor, D., Toth, R. & Rouse, J. 15 Mar 2016 In : Genes and Development. 30, 6, p. 639-644 6 p.

    Research output: Contribution to journalArticle

  17. CDK1-Cyclin B1 Activates RNMT, Coordinating mRNA Cap Methylation with G1 Phase Transcription

    Aregger, M., Kaskar, A., Varshney, D., Fernandez-Sanchez, M. E., Inesta-Vaquera, F. A., Weidlich, S. & Cowling, V. H. 3 Mar 2016 In : Molecular Cell. 61, 5, p. 734-746 13 p.

    Research output: Contribution to journalArticle

  18. AMP-activated protein kinase: a cellular energy sensor that comes in twelve flavours

    Ross, F. A., MacKintosh, C. & Hardie, D. G. 2 Mar 2016 In : FEBS Journal.

    Research output: Contribution to journalArticle

  19. Metadata management for high content screening in OMERO

    Li, S. , Besson, S. , Blackburn, C. , Carroll, M. , Ferguson, R. K. , Flynn, H. , Gillen, K. , Leigh, R. , Lindner, D. , Linkert, M. , Moore, W. J. , Ramalingam, B. , Rozbicki, E. , Rustici, G. , Tarkowska, A. , Walczysko, P. , Williams, E. , Allan, C. , Burel, J. M. & 2 others Moore, J. & Swedlow, J. R. 1 Mar 2016 In : Methods. p. 27-32

    Research output: Contribution to journalArticle

  20. Goserelin, as an ovarian protector during (neo)adjuvant breast cancer chemotherapy, prevents long term altered bone turnover

    Wilson, C., Gossiel, F., Leonard, R., Anderson, R. A., Adamson, D. J. A., Thomas, G. & Coleman, R. E. Mar 2016 In : Journal of Bone Oncology. 5, 1, p. 43-49 7 p.

    Research output: Contribution to journalArticle

  21. How the oxygen tolerance of a [NiFe]-hydrogenase depends on quaternary structure

    Wulff, P., Thomas, C., Sargent, F. & Armstrong, F. A. Mar 2016 In : Journal of Biological Inorganic Chemistry. 21, 1, p. 121 134 p.

    Research output: Contribution to journalArticle

  22. 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1)

    Hügle, M., Lucas, X., Weitzel, G., Ostrovskyi, D., Breit, B., Gerhardt, S., Einsle, O., Günther, S. & Wohlwend, D. 25 Feb 2016 In : Journal of Medicinal Chemistry. 59, 4, p. 1518-1530 13 p.

    Research output: Contribution to journalArticle

  23. O-GlcNAc transferase inhibitors: Current tools and future challenges

    Trapannone, R., Rafie, K. & Van Aalten, D. M. F. 15 Feb 2016 In : Biochemical Society Transactions. 44, 1, p. 88-93 6 p.

    Research output: Contribution to journalArticle

  24. The Diffusible Signal Factor Family of Bacterial Cell-Cell Signals

    Dow, J. M., Naughton, L. M., Hollmann, B., An, S. Q. & Ryan, R. P. 12 Feb 2016 In : Israel Journal of Chemistry.

    Research output: Contribution to journalArticle

  25. Ribozymes and the mechanisms that underlie RNA catalysis

    Wilson, T. J., Liu, Y. & Lilley, D. M. J. 5 Feb 2016 In : Frontiers of Chemical Science and Engineering. 10, 2, p. 178-185 8 p.

    Research output: Contribution to journalArticle

  26. Uranium bioprecipitation mediated by yeasts utilizing organic phosphorus substrates

    Liang, X., Csetenyi, L. & Gadd, G. M. 5 Feb 2016 In : Applied Microbiology and Biotechnology. 100, 11, p. 5141-5151 11 p.

    Research output: Contribution to journalArticle

  27. Biophysical characterization of laforin-carbohydrate interaction

    Dias, D. M., Furtado, J., Wasielewski, E., Cruz, R., Costello, B., Cole, L., Faria, T. Q., Baaske, P., Brito, R. M. M., Ciulli, A., Simões, I., Macedo-Ribeiro, S., Faro, C., Geraldes, C. F. G. C. & Castanheira, P. 1 Feb 2016 In : Biochemical Journal. 473, 3, p. 335-345 11 p.

    Research output: Contribution to journalArticle

  28. IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

    Trost, M. & 22 others Naujoks, J., Tabeling, C., Dill, B. D., Hoffmann, C., Brown, A. S., Kunze, M., Kempa, S., Peter, A., Mollenkopf, H. J., Dorhoi, A., Kershaw, O., Gruber, A. D., Sander, L. E., Witzenrath, M., Herold, S., Nerlich, A., Hocke, A. C., van Driel, I., Suttorp, N., Bedoui, S., Hilbi, H. & Opitz, B. 1 Feb 2016 In : PLoS Pathogens. 12, 2, 27 p., e1005408

    Research output: Contribution to journalArticle

  29. Hand dermatitis in construction workers: a lesson in genetic epidemiology

    Brown, S. J. Feb 2016 In : British Journal of Dermatology. 174, 2, p. 263-265 3 p.

    Research output: Contribution to journalArticle

  30. NF-κB and HIF crosstalk in immune responses

    D'Ignazio, L., Bandarra, D. & Rocha, S. Feb 2016 In : FEBS Journal. 283, 3, p. 413-424 12 p.

    Research output: Contribution to journalArticle

  31. Non-Invasive Intravital Imaging of siRNA-Mediated Mutant Keratin Gene Repression in Skin

    Hickerson, R. P., Speaker, T. J., Lara, M. F., González-González, E., Flores, M. A., Contag, C. H. & Kaspar, R. L. Feb 2016 In : Molecular Imaging and Biology. 18, 1, p. 34-42 9 p.

    Research output: Contribution to journalArticle

  32. A Phytophthora infestans RXLR effector targets plant PP1c isoforms that promote late blight disease

    Boevink, P. C., Wang, X., McLellan, H., He, Q., Naqvi, S., Armstrong, M. R., Zhang, W., Hein, I., Gilroy, E. M., Tian, Z. & Birch, P. R. J. 29 Jan 2016 In : Nature Communications. 7, 10311

    Research output: Contribution to journalArticle

  33. Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases

    Steger, M., Tonelli, F., Ito, G., Davies, P., Trost, M., Vetter, M., Wachter, S., Lorentzen, E., Duddy, G., Wilson, S., Baptista, M. A. S., Fiske, B. K., Fell, M. J., Morrow, J. A., Reith, A. D., Alessi, D. R. & Mann, M. 29 Jan 2016 In : eLife. 5, JANUARY2016, e12813

    Research output: Contribution to journalArticle

  34. The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway

    Bailly, A., Perrin, A., Bou Malhab, L. J., Pion, E., Larance, M., Nagala, M., Smith, P., O'Donohue, M-F., Gleizes, P-E., Zomerdijk, J., Lamond, A. I. & Xirodimas, D. P. 28 Jan 2016 In : Oncogene. 35, 4, p. 415-426 12 p.

    Research output: Contribution to journalArticle

  35. Sialylation and immune surveillance of cancer by siglecs

    Crocker, P. R. & Mohan, B. 27 Jan 2016 Glycosignals in Cancer: Mechanisms of Malignant Phenotypes. p. 125-138 14 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  36. Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms

    Ross, F. A., Jensen, T. E. & Hardie, D. G. 15 Jan 2016 In : Biochemical Journal. 473, 2, p. 189-199 11 p.

    Research output: Contribution to journalArticle

  37. Discovery and profiling of small RNAs responsive to stress conditions in the plant pathogen Pectobacterium atrosepticum

    Kwenda, S., Gorshkov, V., Ramesh, A. M., Naidoo, S., Rubagotti, E., Birch, P. R. J. & Moleleki, L. N. 12 Jan 2016 In : BMC Genomics. 17, 1, 47

    Research output: Contribution to journalArticle

  38. A Generic Platform for Cellular Screening Against Ubiquitin Ligases

    Maculins, T., Carter, N., Dorval, T., Hudson, K., Nissink, J. W. M., Hay, R. T. & Alwan, H. 8 Jan 2016 In : Scientific Reports. 6, 18940

    Research output: Contribution to journalArticle

  39. PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53

    Wimmer, P., Berscheminski, J., Blanchette, P., Groitl, P., Branton, P. E., Hay, R. T., Dobner, T. & Schreiner, S. 7 Jan 2016 In : Oncogene. 35, p. 69-82 14 p.

    Research output: Contribution to journalArticle

  40. Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities

    Teresa Pinto, A., Laranjeiro Pinto, M., Patrícia Cardoso, A., Monteiro, C., Teixeira Pinto, M., Filipe Maia, A., Castro, P., Figueira, R., Monteiro, A., Marques, M., Mareel, M., Dos Santos, S. G., Seruca, R., Adolfo Barbosa, M., Rocha, S. & JoséOliveira, M. 6 Jan 2016 In : Scientific Reports. 6, 18765

    Research output: Contribution to journalArticle

  41. Optimization of inhibitors of Mycobacterium tuberculosis pantothenate synthetase based on group efficiency analysis

    Hung, A. W., Silvestre, H. L., Wen, S., George, G. P. C., Boland, J., Blundell, T. L., Ciulli, A. & Abell, C. 5 Jan 2016 In : ChemMedChem. 11, 1, p. 38-42

    Research output: Contribution to journalArticle

  42. Aim, Load, Fire: The Type VI Secretion System, a Bacterial Nanoweapon

    Cianfanelli, F. R., Monlezun, L. & Coulthurst, S. J. Jan 2016 In : Trends in Microbiology. 24, 1, p. 51-62 12 p.

    Research output: Contribution to journalArticle

  43. Bacterial signal transduction by cyclic di-GMP and other nucleotide second messengers

    Hengge, R., Gründling, A., Jenal, U., Ryan, R. & Yildiz, F. Jan 2016 In : Journal of Bacteriology. 198, 1, p. 15-26 12 p.

    Research output: Contribution to journalArticle

  44. CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells

    Ortmann, B., Bensaddek, D., Carvalhal, S., Moser, S. C., Mudie, S., Griffis, E. R., Swedlow, J. R., Lamond, A. I. & Rocha, S. Jan 2016 In : Journal of Cell Science. 129, 1, p. 191-205 15 p.

    Research output: Contribution to journalArticle

  45. Endemic Mimosa species from Mexico prefer alphaproteobacterial rhizobial symbionts

    Bontemps, C., Rogel, M. A., Wiechmann, A., Mussabekova, A., Moody, S., Simon, M. F., Moulin, L., Elliott, G. N., Lacercat-Didier, L., Dasilva, C., Grether, R., Camargo-Ricalde, S. L., Chen, W., Sprent, J. I., Martínez-Romero, E., Young, J. P. W. & James, E. K. Jan 2016 In : New Phytologist. 209, 1, p. 319-333 15 p.

    Research output: Contribution to journalArticle

  46. Pluses and minuses of ammonium and nitrate uptake and assimilation by phytoplankton and implications for productivity and community composition, with emphasis on nitrogen-enriched conditions

    Glibert, P. M., Wilkerson, F. P., Dugdale, R. C., Raven, J. A., Dupont, C. L., Leavitt, P. R., Parker, A. E., Burkholder, J. M. & Kana, T. M. Jan 2016 In : Limnology and Oceanography. 61, 1, p. 165-197 33 p., 10203

    Research output: Contribution to journalArticle

  47. Secreted cyclic di-GMP induces stalk cell differentiation in the eukaryote Dictyostelium discoideum

    Chen, Z. H. & Schaap, P. Jan 2016 In : Journal of Bacteriology. 198, 1, p. 27-31 5 p.

    Research output: Contribution to journalArticle

  48. Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex

    Heider, M. R., Gu, M., Duffy, C. M., Mirza, A. M., Marcotte, L. L., Walls, A. C., Farrall, N., Hakhverdyan, Z., Field, M. C., Rout, M. P., Frost, A. & Munson, M. Jan 2016 In : Nature Structural & Molecular Biology. 23, 1, p. 59-66 8 p.

    Research output: Contribution to journalArticle

  49. The cytotoxic T cell proteome and its shaping by the kinase mTOR

    Hukelmann, J. L., Anderson, K. E., Sinclair, L. V., Grzes, K. M., Brenes Murillo, A., Hawkins, P. T., Stephens, L. R., Lamond, A. I. & Cantrell, D. A. Jan 2016 In : Nature Immunology. 17, 1, p. 104-112 9 p.

    Research output: Contribution to journalArticle

  50. The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability

    Salifou, K., Ray, S., Verrier, L., Aguirrebengoa, M., Trouche, D., Panov, K. I. & Vandromme, M. Jan 2016 In : Nature Communications. 7, 10174

    Research output: Contribution to journalArticle

  51. The ins and outs of CO2

    Raven, J. A. & Beardall, J. Jan 2016 In : Journal of Experimental Botany. 67, 1, p. 1-13 13 p.

    Research output: Contribution to journalArticle

  52. The state-of-the art in macromolecular crystallization: The IYCr series concludes

    Weiss, M. S., Hunter, W. N. & Einspahr, H. M. 2016 In : Acta Crystallographica Section F: Structural Biology Communications. 72, p. 1 1 p.

    Research output: Contribution to journalArticle

  53. The use of the Rx spin label in orientation measurement on proteins, by EPR

    Stevens, M. A., McKay, J. E., Robinson, J. L. S., El Mkami, H., Smith, G. M. & Norman, D. G. 2016 In : Physical Chemistry Chemical Physics. 18, 8, p. 5799-5806 8 p.

    Research output: Contribution to journalArticle

  54. Biology is simple

    Newman, T. 30 Dec 2015 In : Physical Biology. 12, 6, 063002

    Research output: Contribution to journalArticle

  55. Evidence for a functional O-linked N-acetylglucosamine (O-GlcNAc) system in the thermophilic bacterium Thermobaculum terrenum

    Ostrowski, A., Gundogdu, M., Ferenbach, A. T., Lebedev, A. A. & Van Aalten, D. M. F. 18 Dec 2015 In : Journal of Biological Chemistry. 290, 51, p. 30291-30305 15 p.

    Research output: Contribution to journalArticle

  56. Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome

    Jones, D. C., Foth, B. J., Urbaniak, M. D., Patterson, S., Ong, H. B., Berriman, M. & Fairlamb, A. H. 18 Dec 2015 In : PLoS Neglected Tropical Diseases. 9, 12, e0004299

    Research output: Contribution to journalArticle

  57. Dual functionality of O-GlcNAc transferase is required for Drosophila development

    Mariappa, D., Zheng, X., Schimpl, M., Raimi, O., Ferenbach, A. T., Müller, H-A. J. & van Aalten, D. M. F. 16 Dec 2015 In : Open Biology. 5, 12, 10 p., 150234

    Research output: Contribution to journalArticle

  58. The Pratylenchus penetrans transcriptome as a source for the development of alternative control strategies: mining for putative genes involved in parasitism and evaluation of in planta RNAi

    Vieira, P., Eves-Van Den Akker, S., Verma, R., Wantoch, S., Eisenback, J. D. & Kamo, K. 14 Dec 2015 In : PLoS ONE. 10, 12, 25 p., 0144674

    Research output: Contribution to journalArticle

  59. Subverting toll-like receptor signaling by bacterial pathogens

    McGuire, V. A. & Arthur, J. S. C. 1 Dec 2015 In : Frontiers in Immunology. 6, DEC, 8 p., 607

    Research output: Contribution to journalArticle

  60. Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis

    Riethmuller, C., McAleer, M. A., Koppes, S. A., Abdayem, R., Franz, J., Haftek, M., Campbell, L. E., MacCallum, S. F., McLean, W. H. I., Irvine, A. D. & Kezic, S. Dec 2015 In : Journal of Allergy and Clinical Immunology. 136, 6, p. 1573-1580.e2 10 p.

    Research output: Contribution to journalArticle

  61. Granville Sharp Pattison (1791.–1851.): Škotski anatom i kirurg sklon sukobima

    Dantoni, A. V., Loukas, M., Black, S. & Shane Tubbs, R. Dec 2015 13, 2, p. 405-414 10 p.

    Research output: Contribution to journalArticle

  62. Integration of an [FeFe]-hydrogenase into the anaerobic metabolism of Escherichia coli

    Kelly, C. L., Pinske, C., Murphy, B. J., Parkin, A., Armstrong, F., Palmer, T. & Sargent, F. Dec 2015 In : Biotechnology Reports. 8, p. 94-104 11 p.

    Research output: Contribution to journalArticle

  63. The Concise Guide to PHARMACOLOGY 2015/16: Overview

    Alexander, S. P. H., Kelly, E., Marrion, N., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., Buneman, O. P., Catterall, W. A., Cidlowski, J. A., Davenport, A. P., Fabbro, D., Fan, G., McGrath, J. C., Spedding, M. & Davies, J. A. Dec 2015 In : British Journal of Pharmacology. 172, 24, p. 5729-5743 15 p.

    Research output: Contribution to journalArticle

  64. Role of structural dynamics at the receptor G protein interface for signal transduction

    Rose, A. S., Zachariae, U., Grubmüller, H., Hofmann, K. P., Scheerer, P. & Hildebrand, P. W. 25 Nov 2015 In : PLoS ONE. 10, 11, 13 p., e0143399

    Research output: Contribution to journalArticle

  65. GacA is essential for Group A Streptococcus and defines a new class of monomeric dTDP-4-dehydrorhamnose reductases (RmlD)

    van der Beek, S. L., Le Breton, Y., Ferenbach, A. T., Chapman, R. N., van Aalten, D. M. F., Navratilova, I., Boons, G. J., Mciver, K. S., van Sorge, N. M. & Dorfmueller, H. C. 24 Nov 2015 In : Molecular Microbiology. 98, 5, p. 946-962 16 p.

    Research output: Contribution to journalArticle

  66. Correction: Modulation of the surface proteome through multiple ubiquitylation pathways in African Trypanosomes

    Zoltner, M., Leung, K. F., Alsford, S., Horn, D. & Field, M. C. 23 Nov 2015 In : PLoS Pathogens. 11, 11, 3 p., e1005291

    Research output: Contribution to journalArticle

  67. The evolution of aggregative multicellularity and cell-cell communication in the Dictyostelia

    Du, Q., Kawabe, Y., Schilde, C., Chen, Z. & Schaap, P. 20 Nov 2015 In : Journal of Molecular Biology. 427, 23, p. 3722-3733 12 p.

    Research output: Contribution to journalArticle

  68. MTOR, PIK3C3, and autophagy: Signaling the beginning from the end

    Munson, M. J. & Ganley, I. G. 13 Nov 2015 In : Autophagy. 11, 12, p. 2375-2376 2 p.

    Research output: Contribution to journalArticle

  69. Development of small-molecule Trypanosoma brucei N-myristoyltransferase inhibitors: discovery and optimisation of a novel binding mode

    Spinks, D., Smith, V., Thompson, S., Robinson, D. A., Luksch, T., Smith, A., Torrie, L. S., McElroy, S., Stojanovski, L., Norval, S., Collie, I. T., Hallyburton, I., Rao, B., Brand, S., Brenk, R., Frearson, J. A., Read, K. D., Wyatt, P. G. & Gilbert, I. H. Nov 2015 In : ChemMedChem. 10, 11, p. 1821-1836 16 p.

    Research output: Contribution to journalArticle

  70. Discovery of inhibitors of Trypanosoma brucei by phenotypic screening of a focused protein kinase library

    Woodland, A., Thompson, S., Cleghorn, L. A. T., Norcross, N., De Rycker, M., Grimaldi, R., Hallyburton, I., Rao, B., Norval, S., Stojanovski, L., Brun, R., Kaiser, M., Frearson, J. A., Gray, D. W., Wyatt, P. G., Read, K. D. & Gilbert, I. H. Nov 2015 In : ChemMedChem. 10, 11, p. 1809-1820 12 p.

    Research output: Contribution to journalArticle

  71. Growth rate hypothesis and efficiency of protein synthesis under different sulphate concentrations in two green algae

    Giordano, M., Palmucci, M. & Raven, J. A. Nov 2015 In : Plant, Cell & Environment. 38, 11, p. 2313-2317 5 p.

    Research output: Contribution to journalArticle

  72. Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin

    McAleer, M. A., Pohler, E., Smith, F. J. D., Wilson, N. J., Cole, C., MacGowan, S., Koetsier, J. L., Godsel, L. M., Harmon, R. M., Gruber, R., Crumrine, D., Elias, P. M., McDermott, M., Butler, K., Broderick, A., Sarig, O., Sprecher, E., Green, K. J., McLean, W. H. I. & Irvine, A. D. Nov 2015 In : Journal of Allergy and Clinical Immunology. 136, 5, p. 1268-1276 9 p.

    Research output: Contribution to journalArticle

  73. The bacterial hydrophobin BslA is a switchable ellipsoidal Janus nanocolloid

    Brandani, G. B., Schor, M., Morris, R., Stanley-Wall, N., MacPhee, C. E., Marenduzzo, D. & Zachariae, U. 27 Oct 2015 In : Langmuir. 31, 42, p. 11558-11563 6 p.

    Research output: Contribution to journalArticle

  74. Modulation of the surface proteome through multiple ubiquitylation pathways in African Trypanosomes

    Zoltner, M., Leung, K. F., Alsford, S., Horn, D. & Field, M. C. 22 Oct 2015 In : PLoS Pathogens. 11, 10, 26 p., e1005236

    Research output: Contribution to journalArticle

  75. Discovery and optimisation studies of antimalarial phenotypic hits

    Mital, A., Murugesan, D., Kaiser, M., Yeates, C. & Gilbert, I. H. 20 Oct 2015 In : European Journal of Medicinal Chemistry. 103, p. 530-538 9 p.

    Research output: Contribution to journalArticle

  76. Expanding the clinical spectrum of hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis due to FAM111B mutations

    Mercier, S. , Küry, S. , Salort-Campana, E. , Magot, A. , Agbim, U. , Besnard, T. , Bodak, N. , Bou-Hanna, C. , Bréhéret, F. , Brunelle, P. , Caillon, F. , Chabrol, B. , Cormier-Daire, V. , David, A. , Eymard, B. , Faivre, L. , Figarella-Branger, D. , Fleurence, E. , Ganapathi, M. & 35 others Gherardi, R., Goldenberg, A., Hamel, A., Igual, J., Irvine, A. D., Israël-Biet, D., Kannengiesser, C., Laboisse, C., Le Caignec, C., Mahé, J. Y., Mallet, S., MacGowan, S., McAleer, M. A., McLean, I., Méni, C., Munnich, A., Mussini, J. M., Nagy, P. L., Odel, J., O'Regan, G. M., Péréon, Y., Perrier, J., Piard, J., Puzenat, E., Sampson, J. B., Smith, F., Soufir, N., Tanji, K., Thauvin, C., Ulane, C., Watson, R. M., Khumalo, N. P., Mayosi, B. M., Barbarot, S. & Bézieau, S. 15 Oct 2015 In : Orphanet Journal of Rare Diseases. 10, 16 p., 135

    Research output: Contribution to journalArticle

  77. Drosophila E-cadherin is required for the maintenance of ring canals anchoring to mechanically withstand tissue growth

    Loyer, N., Kolotuev, I., Pinot, M. & Borgne, R. L. 13 Oct 2015 In : Proceedings of the National Academy of Sciences of the United States of America. 112, 41, p. 12717-12722 6 p.

    Research output: Contribution to journalArticle

  78. Discovery of indoline-2-carboxamide derivatives as a new class of brain-penetrant inhibitors of Trypanosoma brucei

    Cleghorn, L. A. T., Albrecht, S., Stojanovski, L., Simeons, F. R. J., Norval, S., Kime, R., Collie, I. T., De Rycker, M., Campbell, L., Hallyburton, I., Frearson, J. A., Wyatt, P. G., Read, K. D. & Gilbert, I. H. 8 Oct 2015 In : Journal of Medicinal Chemistry. 58, 19, p. 7695-7706 12 p.

    Research output: Contribution to journalArticle

  79. BACE1 activity impairs neuronal glucose oxidation: rescue by beta-hydroxybutyrate and lipoic acid

    Findlay, J. A., Hamilton, D. L. & Ashford, M. L. 1 Oct 2015 In : Frontiers in Cellular Neuroscience. 9, 14 p., 382

    Research output: Contribution to journalArticle

  80. The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation

    Carvalhal, S., Abreu Ribeiro, S., Arocena, M., Kasciukovic, T., Temme, A., Koehler, K., Huebner, A. & Griffis, E. R. 1 Oct 2015 In : Molecular Biology of the Cell. 26, 19, p. 3424-3438 15 p.

    Research output: Contribution to journalArticle

  81. Leishmania major UDP-sugar pyrophosphorylase salvages galactose for glycoconjugate biosynthesis

    Damerow, S., Hoppe, C., Bandini, G., Zarnovican, P., Buettner, F. F. R., Ferguson, M. A. J. & Routier, F. H. Oct 2015 In : International Journal for Parasitology. 45, 12, p. 783-790 8 p.

    Research output: Contribution to journalArticle

  82. AtRTD - a comprehensive reference transcript dataset resource for accurate quantification of transcript - specific expression in Arabidopsis thaliana

    Zhang, R., Calixto, C. P. G., Tzioutziou, N. A., James, A. B., Simpson, C. G., Guo, W., Marquez, Y., Kalyna, M., Patro, R., Eyras, E., Barta, A., Nimmo, H. G. & Brown, J. W. S. Oct 2015 In : New Phytologist. 208, 1, p. 96-101 6 p.

    Research output: Contribution to journalArticle

  83. DNA entropy reveals a significant difference in complexity between housekeeping and tissue specific gene promoters

    Thomas, D., Finan, C., Newport, M. J. & Jones, S. Oct 2015 In : Computational Biology and Chemistry. 58, p. 19-24 6 p.

    Research output: Contribution to journalArticle

  84. The TatC component of the twin-arginine protein translocase functions as an obligate oligomer

    Cléon, F., Habersetzer, J., Alcock, F., Kneuper, H., Stansfeld, P. J., Basit, H., Wallace, M. I., Berks, B. C. & Palmer, T. Oct 2015 In : Molecular Microbiology. 98, 1, p. 111-129 19 p.

    Research output: Contribution to journalArticle

  85. Visualization of the Serratia type VI secretion system reveals unprovoked attacks and dynamic assembly

    Gerc, A. J., Diepold, A., Trunk, K., Porter, M., Rickman, C., Armitage, J. P., Stanley-Wall, N. R. & Coulthurst, S. J. 29 Sep 2015 In : Cell Reports. 12, 12, p. 2131-2142 12 p.

    Research output: Contribution to journalArticle

  86. Cohort comparison study of cardiac disease and atherosclerotic burden in type 2 diabetic adults using whole body cardiovascular magnetic resonance imaging

    Duce, S. L., Weir-McCall, J. R., Gandy, S. J., Matthew, S. Z., Cassidy, D. B., McCormick, L., Rauchhaus, P., Looker, H., Colhoun, H. M. & Houston, J. G. 18 Sep 2015 In : Cardiovascular Diabetology. 14, 11 p., 122

    Research output: Contribution to journalArticle

  87. To hit or not to hit, that is the question -genome-wide structure-based druggability predictions for pseudomonas aeruginosa proteins

    Sarkar, A. & Brenk, R. 11 Sep 2015 In : PLoS ONE. 10, 9, 16 p., e0137279

    Research output: Contribution to journalArticle

  88. A balance of positive and negative regulators determines the pace of the segmentation clock

    Wiedermann, G., Bone, R. A., Silva, J. C., Bjorklund, M., Murray, P. J. & Dale, J. K. 10 Sep 2015 In : eLife. 4, 28 p., e05842

    Research output: Contribution to journalArticle

  89. A host KH RNA-binding protein is a susceptibility factor targeted by an RXLR effector to promote late blight disease

    Wang, X., Boevink, P., McLellan, H., Armstrong, M., Bukharova, T., Qin, Z. & Birch, P. R. J. 7 Sep 2015 In : Molecular Plant. 8, 9, p. 1385-1395 11 p.

    Research output: Contribution to journalArticle

  90. Binding of SGTA to Rpn13 selectively modulates protein quality control

    Leznicki, P., Korac-Prlic, J., Kliza, K., Husnjak, K., Nyathi, Y., Dikic, I. & High, S. 1 Sep 2015 In : Journal of Cell Science. 128, 17, p. 3187-3196 10 p.

    Research output: Contribution to journalArticle

  91. Giving structure to the biofilm matrix: an overview of individual strategies and emerging common themes

    Hobley, L., Harkins, C., MacPhee, C. E. & Stanley-Wall, N. R. 1 Sep 2015 In : FEMS Microbiology Reviews. 39, 5, p. 649-669 21 p.

    Research output: Contribution to journalArticle

  92. GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling

    Stretton, C., Hoffmann, T. M., Munson, M. J., Prescott, A., Taylor, P. M., Ganley, I. G. & Hundal, H. 1 Sep 2015 In : Biochemical Journal. 470, 2, p. 207-221

    Research output: Contribution to journalArticle

  93. NEU3 sialidase as a marker of insulin sensitivity: Regulation by fatty acids

    Lipina, C., Nardi, F., Grace, H. & Hundal, H. S. 1 Sep 2015 In : Cellular Signalling. 27, 9, p. 1742-1750 9 p.

    Research output: Contribution to journalArticle

  94. Screen for multi-SUMO-binding proteins reveals a multi-SIM-binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin

    Aguilar-Martinez, E., Chen, X., Webber, A., Mould, A. P., Seifert, A., Hay, R. T. & Sharrocks, A. D. 1 Sep 2015 In : Proceedings of the National Academy of Sciences of the United States of America. 112, 35, p. E4854-E4863 10 p.

    Research output: Contribution to journalArticle

  95. A mutant O-GlcNAcase as a probe to reveal global dynamics of protein O-GlcNAcylation during Drosophila embryonic development

    Mariappa, D., Selvan, N., Borodkin, V. S., Alonso , J., Ferenbach, A. T., Shepherd, C., Navratilova, I. H. & Van Aalten, D. M. F. Sep 2015 In : Biochemical Journal. 470, 2, p. 255-262 8 p.

    Research output: Contribution to journalArticle

  96. A proposed harmonized LPS molecular-subtyping scheme for Cronobacter species

    Yan, Q., Jarvis, K. G., Chase, H. R., Hébert, K., Trach, L. H., Lee, C., Sadowski, J., Lee, B., Hwang, S., Sathyamoorthy, V., Mullane, N., Pava-Ripoll, M., Iversen, C., Pagotto, F., Fanning, S. & Tall, B. D. Sep 2015 In : Food Microbiology. 50, p. 38-43 6 p.

    Research output: Contribution to journalArticle

  97. Could land-based early photosynthesizing ecosystems have bioengineered the planet in mid-Palaeozoic times?

    Edwards, D., Cherns, L. & Raven, J. A. Sep 2015 In : Palaeontology. 58, 5, p. 803-837 35 p.

    Research output: Contribution to journalArticle

  98. High-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow-derived macrophages

    Guo, M., Härtlova, A., Dill, B. D., Prescott, A. R., Gierliński, M. & Trost, M. Sep 2015 In : Proteomics. 15, 18, p. 3169-3174 6 p.

    Research output: Contribution to journalArticle

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