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  1. DNA entropy reveals a significant difference in complexity between housekeeping and tissue specific gene promoters

    Thomas, D., Finan, C., Newport, M. J. & Jones, S. Oct 2015 In : Computational Biology and Chemistry. 58, p. 19-24 6 p.

    Research output: Contribution to journalArticle

  2. NEU3 sialidase as a marker of insulin sensitivity: Regulation by fatty acids

    Lipina, C., Nardi, F., Grace, H. & Hundal, H. S. 1 Sep 2015 In : Cellular Signalling. 27, 9, p. 1742-1750 9 p.

    Research output: Contribution to journalArticle

  3. A proposed harmonized LPS molecular-subtyping scheme for Cronobacter species

    Yan, Q., Jarvis, K. G., Chase, H. R., Hébert, K., Trach, L. H., Lee, C., Sadowski, J., Lee, B., Hwang, S., Sathyamoorthy, V., Mullane, N., Pava-Ripoll, M., Iversen, C., Pagotto, F., Fanning, S. & Tall, B. D. Sep 2015 In : Food Microbiology. 50, p. 38-43 6 p.

    Research output: Contribution to journalArticle

  4. Critical role of the SPAK protein kinase CCT domain in controlling blood pressure

    Zhang, J., Siew, K., Macartney, T., O'Shaughnessy, K. M. & Alessi, D. R. 16 Aug 2015 In : Human Molecular Genetics. 24, 16, p. 4545-4558 14 p.

    Research output: Contribution to journalArticle

  5. Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity

    Sola, I., Castellà, S., Viayna, E., Galdeano, C., Taylor, M. C., Gbedema, S. Y., Pérez, B., Clos, M. V., Jones, D. C., Fairlamb, A. H., Wright, C. W., Kelly, J. M. & Muñoz-Torrero, D. 15 Aug 2015 In : Bioorganic & Medicinal Chemistry. 23, 16, p. 5156-5167 12 p.

    Research output: Contribution to journalArticle

  6. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

    Preston, G. C., Sinclair, L. V., Kaskar, A., Hukelmann, J. L., Navarro, M., Ferrero, I., MacDonald, H. R., Cowling, V. H. & Cantrell, D. A. 4 Aug 2015 In : EMBO Journal. 34, 15, p. 2008-2024 17 p.

    Research output: Contribution to journalArticle

  7. Discovery of an unconventional centromere in budding yeast redefines evolution of point centromeres

    Kobayashi, N., Suzuki, Y., Schoenfeld, L., Müller, C., Nieduszynski, C., Wolfe, K. & Tanaka, T. 3 Aug 2015 In : Current Biology. 25, 15, p. 2026-2033 8 p.

    Research output: Contribution to journalArticle

  8. Bacillus anthracis meningitis during an outbreak of injectional anthrax, Scotland, UK

    Dewar, S., Weir-McCall, J. R., Batchelor, L., Cole, S. & Parcell, B. J. 1 Aug 2015 In : Clinical Microbiology and Infection. 21, 8, p. e49-e50 2 p.

    Research output: Contribution to journalArticle

  9. Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

    Kazlauskaite, A., Martínez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H. & Muqit, M. M. K. 1 Aug 2015 In : EMBO Reports. 16, 8, p. 939-954 16 p.

    Research output: Contribution to journalArticle

  10. Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma brucei

    McCulloch, R. & Field, M. C. Aug 2015 In : Trends in Parasitology. 31, 8, p. 346-349 4 p.

    Research output: Contribution to journalArticle

  11. Structural basis for the RING catalyzed synthesis of K63 linked ubiquitin chains

    Branigan, E., Plechanovova, A., Jaffray, E. G., Naismith, J. H. & Hay, R. T. Aug 2015 In : Nature Structural & Molecular Biology. 22, 8, p. 597-602 6 p.

    Research output: Contribution to journalArticle

  12. The biocathode of microbial electrochemical systems and microbially-influenced corrosion

    Kim, B. H., Lim, S. S., Daud, W. R. W., Gadd, G. M. & Chang, I. S. Aug 2015 In : Bioresource Technology. 190, p. 395-401 7 p.

    Research output: Contribution to journalArticle

  13. A versatile strategy for the semisynthetic production of Ser65 phosphorylated ubiquitin and its biochemical and structural characterisation

    Han, C., Pao, K-C., Kazlauskaite, A., Muqit, M. M. K. & Virdee, S. 27 Jul 2015 In : ChemBioChem. 16, 11, p. 1574-1579 6 p.

    Research output: Contribution to journalArticle

  14. Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C.elegans Embryos

    Sonneville, R., Craig, G., Labib, K., Gartner, A. & Blow, J. J. 21 Jul 2015 In : Cell Reports. 12, 3, p. 405-417 13 p.

    Research output: Contribution to journalArticle

  15. Crystal structures reveal that the reaction mechanism of imidazoleglycerol-phosphate dehydratase is controlled by switching Mn(II) coordination

    Bisson, C., Britton, K. L., Sedelnikova, S. E., Rodgers, H. F., Eadsforth, T. C., Viner, R. C., Hawkes, T. R., Baker, P. J. & Rice, D. W. 7 Jul 2015 In : Structure. 23, 7, p. 1236-1245 10 p.

    Research output: Contribution to journalArticle

  16. Proteotoxic stress reprograms the chromatin landscape of SUMO modification

    Seifert, A., Schofield, P., Barton, G. & Hay, R. 7 Jul 2015 In : Science Signaling. 8, 384, p. rs7 14 p.

    Research output: Contribution to journalArticle

  17. A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer, Smo

    Stasiulewicz, M., Gray, S. D., Mastromina, I., Silva, J. C., Bjorklund, M., Seymour, P. A., Booth, D., Thompson, C., Green, R. J., Hall, E. A., Serup, P. & Dale, J. K. 1 Jul 2015 In : Development. 142, 3, p. 2291-2303 13 p.

    Research output: Contribution to journalArticle

  18. Global proteomics analysis of the response to starvation in C. elegans

    Larance, M., Pourkarimi, E., Wang, B., Brenes Murillo, A., Kent, R., Lamond, A. I. & Gartner, A. 1 Jul 2015 In : Molecular & Cellular Proteomics. 14, 7, p. 1989-2001 13 p.

    Research output: Contribution to journalArticle

  19. Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α

    Rog-Zielinska, E. A., Craig, M. A., Manning, J. R., Richardson, R. V., Gowans, G. J., Dunbar, D. R., Gharbi, K., Kenyon, C. J., Holmes, M. C., Hardie, D. G., Smith, G. L. & Chapman, K. E. 1 Jul 2015 In : Cell Death & Differentiation. 22, 7, p. 1106-1116 11 p.

    Research output: Contribution to journalArticle

  20. Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance

    McNeil, E. M., Astell, K. R., Ritchie, A. M., Shave, S., Houston, D. R., Bakrania, P., Jones, H. M., Khurana, P., Wallace, C., Chapman, T., Wear, M. A., Walkinshaw, M. D., Saxty, B. & Melton, D. W. 1 Jul 2015 In : DNA Repair. 31, p. 19-28 10 p.

    Research output: Contribution to journalArticle

  21. Maintenance of distinct melanocyte populations in the interfollicular epidermis

    Glover, J. D., Knolle, S., Wells, K. L., Liu, D., Jackson, I. J., Mort, R. L. & Headon, D. J. 1 Jul 2015 In : Pigment Cell and Melanoma Research. 28, 4, p. 476-480 5 p.

    Research output: Contribution to journalArticle

  22. AMPK dilates resistance arteries via activation of SERCA and BKCa channels in smooth muscle

    Schneider, H., Schubert, K. M., Blodow, S., Kreutz, C-P., Erdogmus, S., Wiedenmann, M., Qiu, J., Fey, T., Ruth, P., Lubomirov, L. T., Pfitzer, G., Mederos y Schnitzler, M., Hardie, D. G., Gudermann, T. & Pohl, U. Jul 2015 In : Hypertension. 66, 1, p. 108-116 9 p.

    Research output: Contribution to journalArticle

  23. Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog

    Rogerson, D. T., Sachdeva, A., Wang, K., Haq, T., Kazlauskaite, A., Hancock, S. M., Huguenin-Dezot, N., Muqit, M. M. K., Fry, A. M., Bayliss, R. & Chin, J. W. Jul 2015 In : Nature Chemical Biology. 11, 7, p. 496-503 8 p.

    Research output: Contribution to journalArticle

  24. Loss-of-function mutations in the gene encoding filaggrin are not strongly associated with chronic actinic dermatitis

    Harkins, C. P., Waters, A., Kerr, A., Campbell, L., McLean, W. H. I., Brown, S. J. & Ibbotson, S. H. Jul 2015 In : Journal of Investigative Dermatology. 135, 7, p. 1919-1921 3 p.

    Research output: Contribution to journalLetter

  25. Mind the gap-deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites-a position paper focussing on carotenoids and polyphenols

    Bohn, T., McDougall, G. J., Alegría, A., Alminger, M., Arrigoni, E., Aura, A-M., Brito, C., Cilla, A., El, S. N., Karakaya, S., Martinez-Cuesta, M. C. & Santos, C. N. Jul 2015 In : Molecular Nutrition & Food Research. 59, 7, p. 1307-1323 17 p.

    Research output: Contribution to journalArticle

  26. Surface flux patterns on planets in circumbinary systems and potential for photosynthesis

    Forgan, D. H., Mead, A., Cockell, C. S. & Raven, J. A. Jul 2015 In : International Journal of Astrobiology. 14, 3, p. 465-478 14 p.

    Research output: Contribution to journalArticle

  27. The changing face of asthma and its relation with microbes

    Earl, C. S., An, S. & Ryan, R. P. Jul 2015 In : Trends in Microbiology. 23, 7, p. 408-418 11 p.

    Research output: Contribution to journalArticle

  28. N-myristoyltransferase is a cell wall target in Aspergillus fumigatus

    Fang, W., Robinson, D. A., Raimi, O. G., Blair, D. E., Harrison, J. R., Lockhart, D. E. A., Torrie, L. S., Ruda, G. F., Wyatt, P. G., Gilbert, I. H. & van Aalten, D. M. F. 19 Jun 2015 In : ACS Chemical Biology. 10, 6, p. 1425-1434 10 p.

    Research output: Contribution to journalArticle

  29. Orthogonal thiol functionalization at a single atomic center for profiling transthiolation activity of E1 activating enzymes

    Stanley, M., Han, C., Knebel, A., Murphy, P., Shpiro, N. & Virdee, S. 19 Jun 2015 In : ACS Chemical Biology. 10, 6, p. 1542-1554 13 p.

    Research output: Contribution to journalArticle

  30. A novel multiple-stage antimalarial agent that inhibits protein synthesis

    Fairlamb, A. H. , Gilbert, I. H. & 61 others Baragana, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Almeida, M. J., Pradhan, A., Porzelle, A., Santos Martinez, M., Bolscher, J. M., Woodland, A., Norval, S., Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Belén Jiménez-Díaz, M., Maria Sanz, L., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Javier Gamo, F., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S., Marfurt, J., Price, R. N., Sinden, R. E., Winzeler, E. A., Charman, S. A., Bebrevska, L., Gray, D. W., Campbell, S., Willis, P. A., Rayner, J. C., Fidock, D. A. & Read, K. D. 18 Jun 2015 In : Nature. 522, 7556, p. 315-320 6 p.

    Research output: Contribution to journalArticle

  31. A link between ATP and SUR2A: a novel mechanism explaining cardioprotection at high altitude

    Mohammed Abdul, K. S., Jovanovic, S., Du, Q., Sukhodub, A. & Jovanovic, A. 15 Jun 2015 In : International Journal of Cardiology. 189, p. 73-76 4 p.

    Research output: Contribution to journalLetter

  32. Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members

    Malik, N., Vollmer, S., Nanda, S. K., Lopez-Pelaez, M., Prescott, A., Gray, N. & Cohen, P. 15 Jun 2015 In : Biochemical Journal. 468, 3, p. 363-372 10 p.

    Research output: Contribution to journalArticle

  33. GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKβ

    Li, Z., Wang, Y., Newton, I. P., Zhang, L., Ji, P. & Li, Z. Jun 2015 In : Cellular Signalling. 27, 6, p. 1237-1245 9 p.

    Research output: Contribution to journalArticle

  34. Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans

    Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J. T-J., Clarke, R., Zheng, S., Saito, A., Kalra, S., Benedict, A. L., Honda, T., Proby, C. M. & Dinkova-Kostova, A. T. Jun 2015 In : Cancer Prevention Research. 8, 6, p. 475-486 12 p.

    Research output: Contribution to journalArticle

  35. Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock in mice

    Yue, M., Hinkle, K., Davies, P., Trushina, E., Fiesel, F., Christenson, T., Schroeder, A., Zhang, L., Bowles, E., Behrouz, B., Lincoln, S., Beevers, J., Milnerwood, A., Kurti, A., McLean, P. J., Fryer, J. D., Springer, W., Dickson, D., Farrer, M. & Melrose, H. Jun 2015 In : Neurobiology of Disease. 78, p. 172-195 24 p.

    Research output: Contribution to journalArticle

  36. Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver

    McGarry, D. J., Chen, W., Chakravarty, P., Lamont, D. L., Wolf, C. R. & Henderson, C. J. Jun 2015 In : Biochemical Journal. 469, 1, p. 25-32 8 p.

    Research output: Contribution to journalArticle

  37. Transformation of vanadinite (Pb5 (VO4 )3 Cl) by fungi

    Ceci, A., Rhee, Y. J., Kierans, M., Hillier, S., Pendlowski, H., Gray, N., Persiani, A. M. & Gadd, G. M. Jun 2015 In : Environmental Microbiology. 17, 6, p. 2018-2034 17 p.

    Research output: Contribution to journalArticle

  38. U-box E3 ubiquitin ligase PUB17 acts in the nucleus to promote specific immune pathways triggered by Phytophthora infestans

    He, Q., McLellan, H., Boevink, P. C., Sadanandom, A., Xie, C., Birch, P. R. J. & Tian, Z. Jun 2015 In : Journal of Experimental Botany. 66, 11, p. 3189-3199 11 p.

    Research output: Contribution to journalArticle

  39. Uranium phosphate biomineralization by fungi

    Liang, X., Hillier, S., Pendlowski, H., Gray, N., Ceci, A. & Gadd, G. M. Jun 2015 In : Environmental Microbiology. 17, 6, p. 2064-2075 12 p.

    Research output: Contribution to journalArticle

  40. Application of RNAi to genomic drug target validation in schistosomes

    Guidi, A., Mansour, N. R., Paveley, R. A., Carruthers, I. M., Besnard, J., Hopkins, A. L., Gilbert, I. H. & Bickle, Q. D. 20 May 2015 In : PLoS Neglected Tropical Diseases. 9, 5, 22 p., e0003801

    Research output: Contribution to journalArticle

  41. Characterization of Arabidopsis transcriptional responses to different aphid species reveals genes that contribute to host susceptibility and non-host resistance

    Jaouannet, M., Morris, J. A., Hedley, P. E. & Bos, J. I. B. 20 May 2015 In : PLoS Pathogens. 11, 5, 26 p., e1004918

    Research output: Contribution to journalArticle

  42. Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance

    Swamy, M., Abeler-Dörner, L., Chettle, J., Mahlakõiv, T., Goubau, D., Chakravarty, P., Ramsay, G., Reis e Sousa, C., Staeheli, P., Blacklaws, B. A., Heeney, J. L. & Hayday, A. C. 19 May 2015 In : Nature Communications. 6, 12 p., 7090

    Research output: Contribution to journalArticle

  43. Protein degradation and dynamic tRNA thiolation fine-tune translation at elevated temperatures

    Tyagi, K. & Pedrioli, P. G. A. 19 May 2015 In : Nucleic Acids Research. 43, 9, p. 4701-4712 12 p.

    Research output: Contribution to journalArticle

  44. Discovery of a pyrrolopyrimidine (JH-II-127), a highly potent, selective, and brain penetrant LRRK2 inhibitor

    Hatcher, J. M., Zhang, J., Choi, H. G., Ito, G., Alessi, D. R. & Gray, N. S. 14 May 2015 In : ACS Medicinal Chemistry Letters. 6, 5, p. 584-589 6 p.

    Research output: Contribution to journalArticle

  45. Neural differentiation of mouse embryonic stem cells in serum-free monolayer culture

    Wongpaiboonwattana, W. & Stavridis, M. P. 14 May 2015 In : JoVE: Journal of Visualized Experiments. 99, e52823

    Research output: Contribution to journalArticle

  46. Structural characterization of LRRK2 inhibitors

    Gilsbach, B. K., Messias, A. C., Ito, G., Sattler, M., Alessi, D. R., Wittinghofer, A. & Kortholt, A. 14 May 2015 In : Journal of Medicinal Chemistry. 58, 9, p. 3751-3756 6 p.

    Research output: Contribution to journalArticle

  47. Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells

    Pallett, L. J., Gill, U. S., Quaglia, A., Sinclair, L. V., Jover-Cobos, M., Schurich, A., Singh, K. P., Thomas, N., Das, A., Chen, A., Fusai, G., Bertoletti, A., Cantrell, D. A., Kennedy, P. T., Davies, N. A., Haniffa, M. & Maini, M. K. 11 May 2015 In : Nature Medicine. 21, 6, p. 591-600 10 p.

    Research output: Contribution to journalArticle

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