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  1. Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling

    Zhou, Z., Tang, A. T., Wong, W. Y., Bamezai, S., Goddard, L. M., Shenkar, R., Zhou, S., Yang, J., Wright, A. C., Foley, M., Arthur, J. S. C., Whitehead, K. J., Awad, I. A., Li, D. Y., Zheng, X. & Kahn, M. L. 7 Apr 2016 In : Nature. 532, 7597, p. 122-126 5 p., 17178

    Research output: Contribution to journalArticle

  2. Combined changes in Wnt signalling response and contact inhibition induce altered proliferation in radiation treated intestinal crypts

    Dunn, S. J., Osborne, J., Appleton, P. L. & Näthke, I. 6 Apr 2016 In : Molecular Biology of the Cell.

    Research output: Contribution to journalArticle

  3. A Trapped Covalent Intermediate of a Glycoside Hydrolase on the Pathway to Transglycosylation. Insights from Experiments and Quantum Mechanics/Molecular Mechanics Simulations

    Raich, L., Borodkin, V., Fang, W., Castro-Lopez, J., van Aalten, D. M. F., Hurtado-Guerrero, R. & Rovira, C. 16 Mar 2016 In : Journal of the American Chemical Society. 138, 10, p. 3325-3332

    Research output: Contribution to journalArticle

  4. CDK1-Cyclin B1 Activates RNMT, Coordinating mRNA Cap Methylation with G1 Phase Transcription

    Aregger, M., Kaskar, A., Varshney, D., Fernandez-Sanchez, M. E., Inesta-Vaquera, F. A., Weidlich, S. & Cowling, V. H. 3 Mar 2016 In : Molecular Cell. 61, 5, p. 734-746 13 p.

    Research output: Contribution to journalArticle

  5. AMP-activated protein kinase: a cellular energy sensor that comes in twelve flavours

    Ross, F. A., MacKintosh, C. & Hardie, D. G. 2 Mar 2016 In : FEBS Journal.

    Research output: Contribution to journalArticle

  6. Metadata management for high content screening in OMERO

    Li, S. , Besson, S. , Blackburn, C. , Carroll, M. , Ferguson, R. K. , Flynn, H. , Gillen, K. , Leigh, R. , Lindner, D. , Linkert, M. , Moore, W. J. , Ramalingam, B. , Rozbicki, E. , Rustici, G. , Tarkowska, A. , Walczysko, P. , Williams, E. , Allan, C. , Burel, J. M. & 2 others Moore, J. & Swedlow, J. R. 1 Mar 2016 In : Methods. p. 27-32

    Research output: Contribution to journalArticle

  7. Goserelin, as an ovarian protector during (neo)adjuvant breast cancer chemotherapy, prevents long term altered bone turnover

    Wilson, C., Gossiel, F., Leonard, R., Anderson, R. A., Adamson, D. J. A., Thomas, G. & Coleman, R. E. Mar 2016 In : Journal of Bone Oncology. 5, 1, p. 43-49 7 p.

    Research output: Contribution to journalArticle

  8. How the oxygen tolerance of a [NiFe]-hydrogenase depends on quaternary structure

    Wulff, P., Thomas, C., Sargent, F. & Armstrong, F. A. Mar 2016 In : Journal of Biological Inorganic Chemistry. 21, 1, p. 121 134 p.

    Research output: Contribution to journalArticle

  9. 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1)

    Hügle, M., Lucas, X., Weitzel, G., Ostrovskyi, D., Breit, B., Gerhardt, S., Einsle, O., Günther, S. & Wohlwend, D. 25 Feb 2016 In : Journal of Medicinal Chemistry. 59, 4, p. 1518-1530 13 p.

    Research output: Contribution to journalArticle

  10. O-GlcNAc transferase inhibitors: Current tools and future challenges

    Trapannone, R., Rafie, K. & Van Aalten, D. M. F. 15 Feb 2016 In : Biochemical Society Transactions. 44, 1, p. 88-93 6 p.

    Research output: Contribution to journalArticle

  11. The Diffusible Signal Factor Family of Bacterial Cell-Cell Signals

    Dow, J. M., Naughton, L. M., Hollmann, B., An, S. Q. & Ryan, R. P. 12 Feb 2016 In : Israel Journal of Chemistry.

    Research output: Contribution to journalArticle

  12. Ribozymes and the mechanisms that underlie RNA catalysis

    Wilson, T. J., Liu, Y. & Lilley, D. M. J. 5 Feb 2016 In : Frontiers of Chemical Science and Engineering. p. 1-8 8 p.

    Research output: Contribution to journalArticle

  13. Uranium bioprecipitation mediated by yeasts utilizing organic phosphorus substrates

    Liang, X., Csetenyi, L. & Gadd, G. M. 5 Feb 2016 In : Applied Microbiology and Biotechnology. p. 1-11 11 p.

    Research output: Contribution to journalArticle

  14. Biophysical characterization of laforin-carbohydrate interaction

    Dias, D. M., Furtado, J., Wasielewski, E., Cruz, R., Costello, B., Cole, L., Faria, T. Q., Baaske, P., Brito, R. M. M., Ciulli, A., Simões, I., Macedo-Ribeiro, S., Faro, C., Geraldes, C. F. G. C. & Castanheira, P. 1 Feb 2016 In : Biochemical Journal. 473, 3, p. 335-345 11 p.

    Research output: Contribution to journalArticle

  15. IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

    Trost, M. & 22 others Naujoks, J., Tabeling, C., Dill, B. D., Hoffmann, C., Brown, A. S., Kunze, M., Kempa, S., Peter, A., Mollenkopf, H. J., Dorhoi, A., Kershaw, O., Gruber, A. D., Sander, L. E., Witzenrath, M., Herold, S., Nerlich, A., Hocke, A. C., van Driel, I., Suttorp, N., Bedoui, S., Hilbi, H. & Opitz, B. 1 Feb 2016 In : PLoS Pathogens. 12, 2, e1005408

    Research output: Contribution to journalArticle

  16. Hand dermatitis in construction workers: a lesson in genetic epidemiology

    Brown, S. J. Feb 2016 In : British Journal of Dermatology. 174, 2, p. 263-265 3 p.

    Research output: Contribution to journalArticle

  17. Non-Invasive Intravital Imaging of siRNA-Mediated Mutant Keratin Gene Repression in Skin

    Hickerson, R. P., Speaker, T. J., Lara, M. F., González-González, E., Flores, M. A., Contag, C. H. & Kaspar, R. L. Feb 2016 In : Molecular Imaging and Biology. 18, 1, p. 34-42 9 p.

    Research output: Contribution to journalArticle

  18. A Phytophthora infestans RXLR effector targets plant PP1c isoforms that promote late blight disease

    Boevink, P. C., Wang, X., McLellan, H., He, Q., Naqvi, S., Armstrong, M. R., Zhang, W., Hein, I., Gilroy, E. M., Tian, Z. & Birch, P. R. J. 29 Jan 2016 In : Nature Communications. 7, 10311

    Research output: Contribution to journalArticle

  19. Iron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD

    Watson, A., Lipina, C., McArdle, H. J., Taylor, P. M. & Hundal, H. May 2016 In : Cellular Signalling. 28, 5, p. 412-424

    Research output: Contribution to journalArticle

  20. Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases

    Steger, M., Tonelli, F., Ito, G., Davies, P., Trost, M., Vetter, M., Wachter, S., Lorentzen, E., Duddy, G., Wilson, S., Baptista, M. A. S., Fiske, B. K., Fell, M. J., Morrow, J. A., Reith, A. D., Alessi, D. R. & Mann, M. 29 Jan 2016 In : eLife. 5, JANUARY2016, e12813

    Research output: Contribution to journalArticle

  21. Sialylation and immune surveillance of cancer by siglecs

    Crocker, P. R. & Mohan, B. 27 Jan 2016 Glycosignals in Cancer: Mechanisms of Malignant Phenotypes. p. 125-138 14 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  22. Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms

    Ross, F. A., Jensen, T. E. & Hardie, D. G. 15 Jan 2016 In : Biochemical Journal. 473, 2, p. 189-199 11 p.

    Research output: Contribution to journalArticle

  23. Discovery and profiling of small RNAs responsive to stress conditions in the plant pathogen Pectobacterium atrosepticum

    Kwenda, S., Gorshkov, V., Ramesh, A. M., Naidoo, S., Rubagotti, E., Birch, P. R. J. & Moleleki, L. N. 12 Jan 2016 In : BMC Genomics. 17, 1, 47

    Research output: Contribution to journalArticle

  24. A Generic Platform for Cellular Screening Against Ubiquitin Ligases

    Maculins, T., Carter, N., Dorval, T., Hudson, K., Nissink, J. W. M., Hay, R. T. & Alwan, H. 8 Jan 2016 In : Scientific Reports. 6, 18940

    Research output: Contribution to journalArticle

  25. Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities

    Teresa Pinto, A., Laranjeiro Pinto, M., Patrícia Cardoso, A., Monteiro, C., Teixeira Pinto, M., Filipe Maia, A., Castro, P., Figueira, R., Monteiro, A., Marques, M., Mareel, M., Dos Santos, S. G., Seruca, R., Adolfo Barbosa, M., Rocha, S. & JoséOliveira, M. 6 Jan 2016 In : Scientific Reports. 6, 18765

    Research output: Contribution to journalArticle

  26. Optimization of inhibitors of Mycobacterium tuberculosis pantothenate synthetase based on group efficiency analysis

    Hung, A. W., Silvestre, H. L., Wen, S., George, G. P. C., Boland, J., Blundell, T. L., Ciulli, A. & Abell, C. 5 Jan 2016 In : ChemMedChem. 11, 1, p. 38-42

    Research output: Contribution to journalArticle

  27. Aim, Load, Fire: The Type VI Secretion System, a Bacterial Nanoweapon

    Cianfanelli, F. R., Monlezun, L. & Coulthurst, S. J. Jan 2016 In : Trends in Microbiology. 24, 1, p. 51-62 12 p.

    Research output: Contribution to journalArticle

  28. Bacterial signal transduction by cyclic di-GMP and other nucleotide second messengers

    Hengge, R., Gründling, A., Jenal, U., Ryan, R. & Yildiz, F. Jan 2016 In : Journal of Bacteriology. 198, 1, p. 15-26 12 p.

    Research output: Contribution to journalArticle

  29. CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells

    Ortmann, B., Bensaddek, D., Carvalhal, S., Moser, S. C., Mudie, S., Griffis, E. R., Swedlow, J. R., Lamond, A. I. & Rocha, S. Jan 2016 In : Journal of Cell Science. 129, 1, p. 191-205 15 p.

    Research output: Contribution to journalArticle

  30. Endemic Mimosa species from Mexico prefer alphaproteobacterial rhizobial symbionts

    Bontemps, C., Rogel, M. A., Wiechmann, A., Mussabekova, A., Moody, S., Simon, M. F., Moulin, L., Elliott, G. N., Lacercat-Didier, L., Dasilva, C., Grether, R., Camargo-Ricalde, S. L., Chen, W., Sprent, J. I., Martínez-Romero, E., Young, J. P. W. & James, E. K. Jan 2016 In : New Phytologist. 209, 1, p. 319-333 15 p.

    Research output: Contribution to journalArticle

  31. Pluses and minuses of ammonium and nitrate uptake and assimilation by phytoplankton and implications for productivity and community composition, with emphasis on nitrogen-enriched conditions

    Glibert, P. M., Wilkerson, F. P., Dugdale, R. C., Raven, J. A., Dupont, C. L., Leavitt, P. R., Parker, A. E., Burkholder, J. M. & Kana, T. M. Jan 2016 In : Limnology and Oceanography. 61, 1, p. 165-197 33 p., 10203

    Research output: Contribution to journalArticle

  32. Secreted cyclic di-GMP induces stalk cell differentiation in the eukaryote Dictyostelium discoideum

    Chen, Z. H. & Schaap, P. Jan 2016 In : Journal of Bacteriology. 198, 1, p. 27-31 5 p.

    Research output: Contribution to journalArticle

  33. Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex

    Heider, M. R., Gu, M., Duffy, C. M., Mirza, A. M., Marcotte, L. L., Walls, A. C., Farrall, N., Hakhverdyan, Z., Field, M. C., Rout, M. P., Frost, A. & Munson, M. Jan 2016 In : Nature Structural & Molecular Biology. 23, 1, p. 59-66 8 p.

    Research output: Contribution to journalArticle

  34. The cytotoxic T cell proteome and its shaping by the kinase mTOR

    Hukelmann, J. L., Anderson, K. E., Sinclair, L. V., Grzes, K. M., Brenes Murillo, A., Hawkins, P. T., Stephens, L. R., Lamond, A. I. & Cantrell, D. A. Jan 2016 In : Nature Immunology. 17, 1, p. 104-112 9 p.

    Research output: Contribution to journalArticle

  35. The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability

    Salifou, K., Ray, S., Verrier, L., Aguirrebengoa, M., Trouche, D., Panov, K. I. & Vandromme, M. Jan 2016 In : Nature Communications. 7, 10174

    Research output: Contribution to journalArticle

  36. The ins and outs of CO2

    Raven, J. A. & Beardall, J. Jan 2016 In : Journal of Experimental Botany. 67, 1, p. 1-13 13 p.

    Research output: Contribution to journalArticle

  37. PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53

    Wimmer, P., Berscheminski, J., Blanchette, P., Groitl, P., Branton, P. E., Hay, R. T., Dobner, T. & Schreiner, S. 2016 In : Oncogene. 35, p. 69-82 14 p.

    Research output: Contribution to journalArticle

  38. The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway

    Bailly, A., Perrin, A., Bou Malhab, L. J., Pion, E., Larance, M., Nagala, M., Smith, P., O'Donohue, M-F., Gleizes, P-E., Zomerdijk, J., Lamond, A. I. & Xirodimas, D. P. 2016 In : Oncogene. 35, p. 415-426 12 p.

    Research output: Contribution to journalArticle

  39. The state-of-the art in macromolecular crystallization: The IYCr series concludes

    Weiss, M. S., Hunter, W. N. & Einspahr, H. M. 2016 In : Acta Crystallographica Section F: Structural Biology Communications. 72, p. 1 1 p.

    Research output: Contribution to journalArticle

  40. The use of the Rx spin label in orientation measurement on proteins, by EPR

    Stevens, M. A., McKay, J. E., Robinson, J. L. S., El Mkami, H., Smith, G. M. & Norman, D. G. 2016 In : Physical Chemistry Chemical Physics. 18, 8, p. 5799-5806 8 p.

    Research output: Contribution to journalArticle

  41. Biology is simple

    Newman, T. 30 Dec 2015 In : Physical Biology. 12, 6, 063002

    Research output: Contribution to journalArticle

  42. Evidence for a functional O-linked N-acetylglucosamine (O-GlcNAc) system in the thermophilic bacterium Thermobaculum terrenum

    Ostrowski, A., Gundogdu, M., Ferenbach, A. T., Lebedev, A. A. & Van Aalten, D. M. F. 18 Dec 2015 In : Journal of Biological Chemistry. 290, 51, p. 30291-30305 15 p.

    Research output: Contribution to journalArticle

  43. Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome

    Jones, D. C., Foth, B. J., Urbaniak, M. D., Patterson, S., Ong, H. B., Berriman, M. & Fairlamb, A. H. 18 Dec 2015 In : PLoS Neglected Tropical Diseases. 9, 12, e0004299

    Research output: Contribution to journalArticle

  44. Dual functionality of O-GlcNAc transferase is required for Drosophila development

    Mariappa, D., Zheng, X., Schimpl, M., Raimi, O., Ferenbach, A. T., Müller, H-A. J. & van Aalten, D. M. F. 16 Dec 2015 In : Open Biology. 5, 12, p. 150234

    Research output: Contribution to journalArticle

  45. The pratylenchus penetrans transcriptome as a source for the development of alternative control strategies: Mining for putative genes involved in parasitism and evaluation of in planta RNAi

    Vieira, P., Eves-Van Den Akker, S., Verma, R., Wantoch, S., Eisenback, J. D. & Kamo, K. 14 Dec 2015 In : PLoS ONE. 10, 12, 25 p., 0144674

    Research output: Contribution to journalArticle

  46. Subverting toll-like receptor signaling by bacterial pathogens

    McGuire, V. A. & Arthur, J. S. C. 1 Dec 2015 In : Frontiers in Immunology. 6, DEC, 8 p., 607

    Research output: Contribution to journalArticle

  47. Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis

    Riethmuller, C., McAleer, M. A., Koppes, S. A., Abdayem, R., Franz, J., Haftek, M., Campbell, L. E., MacCallum, S. F., McLean, W. H. I., Irvine, A. D. & Kezic, S. Dec 2015 In : Journal of Allergy and Clinical Immunology. 136, 6, p. 1573-1580.e2 10 p.

    Research output: Contribution to journalArticle

  48. Integration of an [FeFe]-hydrogenase into the anaerobic metabolism of Escherichia coli

    Kelly, C. L., Pinske, C., Murphy, B. J., Parkin, A., Armstrong, F., Palmer, T. & Sargent, F. Dec 2015 In : Biotechnology Reports. 8, p. 94-104 11 p.

    Research output: Contribution to journalArticle

  49. The Concise Guide to PHARMACOLOGY 2015/16: Overview

    Alexander, S. P. H., Kelly, E., Marrion, N., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., Buneman, O. P., Catterall, W. A., Cidlowski, J. A., Davenport, A. P., Fabbro, D., Fan, G., McGrath, J. C., Spedding, M. & Davies, J. A. Dec 2015 In : British Journal of Pharmacology. 172, 24, p. 5729-5743 15 p.

    Research output: Contribution to journalArticle

  50. Role of structural dynamics at the receptor G protein interface for signal transduction

    Rose, A. S., Zachariae, U., Grubmüller, H., Hofmann, K. P., Scheerer, P. & Hildebrand, P. W. 25 Nov 2015 In : PLoS ONE. 10, 11, 13 p., e0143399

    Research output: Contribution to journalArticle

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