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Division of Cancer Research

  1. Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs

    Wolf, C. R., Kapelyukh, Y., Scheer, N. & Henderson, C. J. 20 Nov 2016 New Horizons in Predictive drug Metabolism and Pharmocokentics. 49 ed. Royal Society of Chemistry, Vol. 2016-January, p. 152-176 25 p. (RSC Drug Discovery Series; vol. 2016-January, no. 49)

    Research output: Chapter in Book/Report/Conference proceedingChapter

  2. The ClearPET/XPAD prototype: Development of a simultaneous PET/CT scanner for mice

    Hamonet, M., Dupont, M., Fabiani, T., Cassol, F., Boursier, Y., Bonissent, A., Debarbieux, F., Pottier, G., Bidaut, L. & Morel, C. 3 Oct 2016 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. Institute of Electrical and Electronics Engineers Inc., p. 1-3 3 p. 7582074

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  3. Tumour suppressor gene (CDKNA2) status on chromosome 9p in resected renal tissue improves prognosis of localised kidney cancer

    El-Mokadem, I., Kidd, T., Pratt, N., Fleming, S. & Nabi, G. 22 Sep 2016 In : Oncotarget. p. 1-10 10 p.

    Research output: Contribution to journalArticle

  4. CREBBP mutation in human cutaneous squamous cell carcinoma

    Watt, S. A., Purdie, K. J., den Breems, N. Y., Dimon, M., Tucker, S., Arron, S. T., Mchugh, A., Xue, D. J., Dayal, J. H. S., Harwood, C. A., Leigh, I. M., Proby, C. M. & South, A. P. Aug 2016 In : Experimental Dermatology. 25, 8, p. 650-651 2 p.

    Research output: Contribution to journalLetter

  5. Rhodiola rosea L.: from golden root to green cell factories

    Marchev, A. S., Dinkova-Kostova, A. T., György, Z., Mirmazloum, I., Aneva, I. Y. & Georgiev, M. I. Aug 2016 In : Phytochemistry Reviews. 15, 4, p. 515-536 22 p.

    Research output: Contribution to journalArticle

  6. SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

    Dinkova-Kostova, A. T. & 23 others Quinti, L., Casale, M., Moniot, S., Pais, T. F., Van Kanegan, M. J., Kaltenbach, L. S., Pallos, J., Lim, R. G., Naidu, S. D., Runne, H., Meisel, L., Rauf, N. A., Leyfer, D., Maxwell, M. M., Saiah, E., Landers, J. E., Luthi-Carter, R., Abagyan, R., Steegborn, C., Marsh, J. L., Lo, D. C., Thompson, L. M. & Kazantsev, A. G. 21 Jul 2016 In : Cell Chemical Biology. 23, 7, p. 849-861 13 p.

    Research output: Contribution to journalArticle

  7. Exosome-mediated transfer from the tumor microenvironment increases TGFβ signaling in squamous cell carcinoma

    Languino, L. R., Singh, A., Prisco, M., Inman, G. J., Luginbuhl, A., Curry, J. M. & South, A. P. 30 May 2016 In : American Journal of Translational Research. 8, 5, p. 2432-2437 6 p.

    Research output: Contribution to journalArticle

  8. Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function

    Esteras, N., Dinkova-Kostova, A. T. & Abramov, A. Y. May 2016 In : Biological Chemistry. 397, 5, p. 383-400 18 p.

    Research output: Contribution to journalArticle

  9. Synthesis, molecular modeling and NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives

    Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K. 7 Apr 2016 In : Journal of Enzyme Inhibition and Medicinal Chemistry. p. 1-7 7 p.

    Research output: Contribution to journalArticle

  10. The heparan sulfate sulfotransferase 3-OST3A (HS3ST3A) is a novel tumor regulator and a prognostic marker in breast cancer

    Mao, X., Gauche, C., Coughtrie, M. W. H., Bui, C., Gulberti, S., Merhi-Soussi, F., Ramalanjaona, N., Bertin-Jung, I., Diot, A., Dumas, D., De Freitas Caires, N., Thompson, A. M., Bourdon, J-C., Ouzzine, M. & Fournel-Gigleux, S. 4 Apr 2016 In : Oncogene. 13 p.

    Research output: Contribution to journalArticle

  11. Making the invisible visible

    van Steensel, M. A. M. 1 Apr 2016 In : Seminars in Cell & Developmental Biology. 52, p. 58-65 8 p.

    Research output: Contribution to journalArticle

  12. Chemical constituents and NAD(P)H:Quinone oxidoreductase 1 (NQO1) inducer activity of Teucrium oliverianum Ging. ex Benth

    Shahat, A. A., Alsaid, M. S., Khan, J. A., Higgins, M. & Dinkova-Kostova, A. T. Apr 2016 In : Indian Journal of Traditional Knowledge. 15, 2, p. 232-236 5 p.

    Research output: Contribution to journalArticle

  13. Locally advanced basal cell carcinoma has a distinct methylation and transcriptomic profile

    Brinkhuizen, T., van Geel, M., Denil, S. L. I. J., De Meyer, T., Kelleners-Smeets, N. W. J., Lohuis, P. J. F. M., Hoebers, F. J. P., Winnepenninckx, V. J. L., van Steensel, M. A. M. & Mosterd, K. Apr 2016 In : Experimental Dermatology. 25, 4, p. 316-318 3 p.

    Research output: Contribution to journalLetter

  14. Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer

    Palmer, S., Litvinova, K., Dunaev, A., Fleming, S., McGloin, D. & Nabi, G. 7 Mar 2016 In : Biomedical Optics Express. 7, 4, p. 1193-2000 8 p.

    Research output: Contribution to journalArticle

  15. The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132

    Remenyi, J., Bajan, S., Fuller-Pace, F. V., Arthur, J. S. C. & Hutvagner, G. 7 Mar 2016 In : Scientific Reports. 6, 13 p., 22848

    Research output: Contribution to journalArticle

  16. Photodynamic diagnostic ureterorenoscopy: a valuable tool in the detection of upper urinary tract tumour

    Kata, S. G., Aboumarzouk, O. M., Zreik, A., Somani, B., Ahmad, S., Nabi, G., Buist, R., Goodman, C., Chlosta, P., Golabek, T. & Moseley, H. Mar 2016 In : Photodiagnosis and Photodynamic Therapy. 13, p. 255-260 6 p.

    Research output: Contribution to journalArticle

  17. A spontaneous increase in intracellular Ca2+ in metaphase II human oocytes in vitro can be prevented by drugs targeting ATP-sensitive K+ channels

    Fernandes, G., Dasai, N., Kozlova, N., Mojadadi, A., Gall, M., Drew, E., Barratt, E., Madamidola, O. A., Brown, S. G., Milne, A. M., Martins Da Silva, S. J., Whalley, K. M., Barratt, C. L. R. & Jovanovic, A. Feb 2016 In : Human Reproduction. 31, 2, p. 287-297 11 p.

    Research output: Contribution to journalArticle

  18. Hand dermatitis in construction workers: a lesson in genetic epidemiology

    Brown, S. J. Feb 2016 In : British Journal of Dermatology. 174, 2, p. 263-265 3 p.

    Research output: Contribution to journalComment/debate

  19. International Consortium on Mammographic Density: methodology and population diversity captured across 22 countries

    McCormack, V. A. , Burton, A. , dos-Santos-Silva, I. , Hipwell, J. H. , Dickens, C. , Salem, D. , Kamal, R. , Hartman, M. , Lee, C. P. L. , Chia, K-S. , Ozmen, V. , Aribal, M. E. , Flugelman, A. A. , Lajous, M. , Lopez-Riduara, R. , Rice, M. , Romieu, I. , Ursin, G. , Qureshi, S. & 37 others Ma, H., Lee, E., van Gils, C. H., Wanders, J. O. P., Vinayak, S., Ndumia, R., Allen, S., Vinnicombe, S., Moss, S., Won Lee, J., Kim, J., Pereira, A., Garmendia, M. L., Sirous, R., Sirous, M., Peplonska, B., Bukowska, A., Tamimi, R. M., Bertrand, K., Nagata, C., Kwong, A., Vachon, C., Scott, C., Perez-Gomez, B., Pollan, M., Maskarinec, G., Giles, G., Hopper, J., Stone, J., Rajaram, N., Teo, S-H., Mariapun, S., Yaffe, M. J., Schüz, J., Chiarelli, A. M., Linton, L. & Boyd, N. F. Feb 2016 In : Cancer Epidemiology. 40, p. 141-151 11 p.

    Research output: Contribution to journalArticle

  20. LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner

    Kramer, H. B., Lai, C-F., Patel, H., Periyasamy, M., Lin, M-L., Feller, S. M., Fuller-Pace, F. V., Meek, D. W., Ali, S. & Buluwela, L. 29 Jan 2016 In : Nucleic Acids Research. 44, 2, p. 582-594 13 p.

    Research output: Contribution to journalArticle

  21. NAD(P)H: Quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives

    Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A. 21 Jan 2016 In : Journal of Enzyme Inhibition and Medicinal Chemistry. 7 p.

    Research output: Contribution to journalArticle

  22. Can angiotensin-converting enzyme inhibitors reduce the incidence, severity, and duration of radiation proctitis?

    Alashkham, A., Paterson, C., Rauchhaus, P. & Nabi, G. Jan 2016 In : International Journal of Radiation Oncology Biology Physics. 94, 1, p. 93-101 9 p.

    Research output: Contribution to journalArticle

  23. Detection of DCIS and reduced invasive interval cancers

    Evans, A. Jan 2016 In : Lancet Oncology. 17, 1, p. 14-15 2 p.

    Research output: Contribution to journalComment/debate

  24. Re: A proposal to standardize reporting units for fecal immunochemical tests for hemoglobin

    Fraser, C. G., Rapi, S. & Rubeca, T. Jan 2016 In : Journal of the National Cancer Institute. 108, 1, 2 p., djv312

    Research output: Contribution to journalLetter

  25. The use of the Rx spin label in orientation measurement on proteins, by EPR

    Stevens, M. A., McKay, J. E., Robinson, J. L. S., El Mkami, H., Smith, G. M. & Norman, D. G. 2016 In : Physical Chemistry Chemical Physics. 18, 8, p. 5799-5806 8 p.

    Research output: Contribution to journalArticle

  26. DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions

    Huang, W. , Thomas, B. , Flynn, R. A. , Gavzy, S. J. , Wu, L. , Kim, S. V. , Hall, J. A. , Miraldi, E. R. , Ng, C. P. , Rigo, F. , Meadows, S. , Montoya, N. R. , Herrera, N. G. , Domingos, A. I. , Rastinejad, F. , Myers, R. M. , Fuller-Pace, F. V. , Bonneau, R. , Chang, H. Y. & 2 others Acuto, O. & Littman, D. R. 24 Dec 2015 In : Nature. 528, 7583, p. 517-522 6 p.

    Research output: Contribution to journalArticle

  27. Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa

    Williams, H. L., Mansell, S., Alasmari, W., Brown, S. G., Wilson, S. M., Sutton, K. A., Miller, M. R., Lishko, P. V., Barratt, C. L. R., Publicover, S. J. & Martins da Silva, S. Dec 2015 In : Human Reproduction. 30, 12, p. 2737-2746 10 p.

    Research output: Contribution to journalArticle

  28. Activation status of the Pregnane X Receptor influences Vemurafenib availability in humanized mouse models

    MacLeod, A. K., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R. 1 Nov 2015 In : Cancer Research. 75, 21, p. 4573-4581 10 p.

    Research output: Contribution to journalArticle

  29. BRCA1 is required for maintenance of phospho-Chk1 and G2/M arrest during DNA cross-link repair in DT40 cells

    Draga, M., Madgett, E. B., Vandenberg, C. J., du Plessis, D., Kaufmann, A., Werler, P., Chakraborty, P., Lowndes, N. F. & Hiom, K. Nov 2015 In : Molecular and Cellular Biology. 35, 22, p. 3829-3840 12 p.

    Research output: Contribution to journalArticle

  30. Defining human pathways of drug metabolism in vivo through the development of a multiple humanized mouse model

    Scheer, N., Kapelyukh, Y., Rode, A., Oswald, S., Busch, D., McLaughlin, L. A., Lin, D., Henderson, C. J. & Wolf, C. R. Nov 2015 In : Drug Metabolism and Disposition. 43, 11, p. 1679-1690 12 p.

    Research output: Contribution to journalArticle

  31. Development of small-molecule Trypanosoma brucei N-myristoyltransferase inhibitors: discovery and optimisation of a novel binding mode

    Spinks, D., Smith, V., Thompson, S., Robinson, D. A., Luksch, T., Smith, A., Torrie, L. S., McElroy, S., Stojanovski, L., Norval, S., Collie, I. T., Hallyburton, I., Rao, B., Brand, S., Brenk, R., Frearson, J. A., Read, K. D., Wyatt, P. G. & Gilbert, I. H. Nov 2015 In : ChemMedChem. 10, 11, p. 1821-1836 16 p.

    Research output: Contribution to journalArticle

  32. Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

    Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D. Nov 2015 In : Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.

    Research output: Contribution to journalArticle

  33. The emerging role of Nrf2 in mitochondrial function

    Dinkova-Kostova, A. T. & Abramov, A. Y. Nov 2015 In : Free Radical Biology and Medicine. 88, Part B, p. 179-188 10 p.

    Research output: Contribution to journalArticle

  34. Trends in socio-economic inequalities in the Scottish diet: 2001-2009

    Barton, K. L., Wrieden, W. L., Sherriff, A., Armstrong, J. & Anderson, A. S. Nov 2015 In : Public Health Nutrition. 18, 16, p. 2970-2980 11 p.

    Research output: Contribution to journalArticle

  35. Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

    Matula, K., Collie-Duguid, E., Murray, G., Parikh, K., Grabsch, H., Tan, P., Lalwani, S., Garau, R., Ong, Y., Bain, G., Smith, A-D., Urquhart, G., Bielawski, J., Finnegan, M. & Petty, R. 22 Oct 2015 In : BMC Cancer. 15, 1, 14 p., 762

    Research output: Contribution to journalArticle

  36. Epidermal Growth Factor (EGFR) copy number aberrations in esophageal and gastro-esophageal junctional carcinoma

    Dahle-Smith, Å., Stevenson, D., Massie, D., Murray, G. I., Dutton, S. J., Roberts, C., Ferry, D., Osborne, A., Clark, C., Petty, R. D. & Miedzybrodzka, Z. 17 Oct 2015 In : Molecular Cytogenetics. 8, 9 p., 78

    Research output: Contribution to journalArticle

  37. APOBEC3B-mediated cytidine deamination is required for estrogen receptor action in breast cancer

    Periyasamy, M., Patel, H., Lai, C-F., Nguyen, V. T. M., Nevedomskaya, E., Harrod, A., Russell, R., Remenyi, J., Ochocka, A. M., Thomas, R. S., Fuller-Pace, F., Győrffy, B., Caldas, C., Navaratnam, N., Carroll, J. S., Zwart, W., Coombes, R. C., Magnani, L., Buluwela, L. & Ali, S. 6 Oct 2015 In : Cell Reports. 13, 1, p. 108-121 14 p.

    Research output: Contribution to journalArticle

  38. FLCN and AMPK confer resistance to hyperosmotic stress via remodeling of glycogen stores

    Possik, E., Ajisebutu, A., Manteghi, S., Gingras, M-C., Vijayaraghavan, T., Flamand, M., Coull, B., Schmeisser, K., Duchaine, T., van Steensel, M., Hall, D. H. & Pause, A. 6 Oct 2015 In : PLoS Genetics. 11, 10, 18 p., e1005520

    Research output: Contribution to journalArticle

  39. Mice lacking beta2-integrin function remain glucose tolerant in spite of insulin resistance, neutrophil infiltration and inflammation

    Meakin, P. J., Morrison, V. L., Sneddon, C. C., Savinko, T., Uotila, L., Jalicy, S. M., Gabriel, J. L., Kang, L., Ashford, M. L. J. & Fagerholm, S. C. 25 Sep 2015 In : PLoS ONE. 10, 9, 15 p., e0138872

    Research output: Contribution to journalArticle

  40. Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1-Nrf2 protein-protein interaction

    Bertrand, H. C., Schaap, M., Baird, L., Georgakopoulos, N. D., Fowkes, A., Thiollier, C., Kachi, H., Dinkova-Kostova, A. T. & Wells, G. 24 Sep 2015 In : Journal of Medicinal Chemistry. 58, 18, p. 7186-7194 9 p.

    Research output: Contribution to journalArticle

  41. Lysyl hydroxylase 3 localizes to epidermal basement membrane and Is reduced in patients with Recessive Dystrophic Epidermolysis Bullosa

    Watt, S. A., Dayal, J. H. S., Wright, S., Riddle, M., Pourreyron, C., McMillan, J. R., Kimble, R. M., Prisco, M., Gartner, U., Warbrick, E., McLean, W. H. I., Leigh, I. M., McGrath, J. A., Salas-Alanis, J. C., Tolar, J. & South, A. P. 18 Sep 2015 In : PLoS ONE. 10, 9, 15 p., e0137639

    Research output: Contribution to journalArticle

  42. A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial

    Harrison, E. F., Haines, R. H., Cowdell, F., Sach, T. H., Dean, T., Pollock, I., Burrows, N. P., Buckley, H., Batchelor, J., Williams, H. C., Lawton, S., Brown, S. J., Bradshaw, L. E., Ahmed, A., Montgomery, A. A., Mitchell, E. J. & Thomas, K. S. 2 Sep 2015 In : Trials. 16, 12 p., 390

    Research output: Contribution to journalArticle

  43. Giving structure to the biofilm matrix: an overview of individual strategies and emerging common themes

    Hobley, L., Harkins, C., MacPhee, C. E. & Stanley-Wall, N. R. 1 Sep 2015 In : FEMS Microbiology Reviews. 39, 5, p. 649-669 21 p.

    Research output: Contribution to journalArticle

  44. Is photodynamic diagnostic flexible ureterorenoscopy suitable for a patient presenting with chronic actinic dermatitis?

    Valentine, R., Kata, S., Ibbotson, S., Nabi, G. & Moseley, H. Sep 2015 In : Photodermatology, Photoimmunology & Photomedicine. 31, 5, p. 279-281 3 p.

    Research output: Contribution to journalLetter

  45. Novel CARD11 mutations in human cutaneous squamous cell carcinoma lead to aberrant NF-κB regulation

    Watt, S. A., Purdie, K. J., den Breems, N. Y., Dimon, M., Arron, S. T., McHugh, A. T., Xue, D. J., Dayal, J. H. S., Proby, C. M., Harwood, C. A., Leigh, I. M. & South, A. P. Sep 2015 In : American Journal of Pathology. 185, 9, p. 2354-2363 10 p.

    Research output: Contribution to journalArticle

  46. Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection

    Yelumalai, S., Yeste, M., Jones, C., Amdani, S. N., Kashir, J., Mounce, G., Martins Da Silva, S. J., Barratt, C. L., McVeigh, E. & Coward, K. Sep 2015 In : Fertility and Sterility. 104, 3, p. 561-568.e4 12 p.

    Research output: Contribution to journalArticle

  47. Synthesis of carbohydrate capped silicon nanoparticles and their reduced cytotoxicity, in vivo toxicity, and cellular uptake

    Ahire, J. H., Behray, M., Webster, C. A., Wang, Q., Sherwood, V., Saengkrit, N., Ruktanonchai, U., Woramongkolchai, N. & Chao, Y. 26 Aug 2015 In : Advanced Healthcare Materials. 4, 12, p. 1877-1886 10 p.

    Research output: Contribution to journalArticle

  48. The fanconi anemia DNA repair pathway is regulated by an interaction between ubiquitin and the E2-like fold domain of FANCL

    Miles, J. A., Frost, M. G., Carroll, E., Rowe, M. L., Howard, M. J., Sidhu, A., Chaugule, V. K., Alpi, A. F. & Walden, H. 21 Aug 2015 In : Journal of Biological Chemistry. 290, 34, p. 20995-21006 12 p.

    Research output: Contribution to journalArticle

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