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Division of Cancer Research

  1. Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs

    Wolf, C. R., Kapelyukh, Y., Scheer, N. & Henderson, C. J. 20 Nov 2016 New Horizons in Predictive drug Metabolism and Pharmocokentics. 49 ed. Royal Society of Chemistry, Vol. 2016-January, p. 152-176 25 p. (RSC Drug Discovery Series; vol. 2016-January, no. 49)

    Research output: Chapter in Book/Report/Conference proceedingChapter

  2. Exosome-mediated transfer from the tumor microenvironment increases TGFβ signaling in squamous cell carcinoma

    Languino, L. R., Singh, A., Prisco, M., Inman, G. J., Luginbuhl, A., Curry, J. M. & South, A. P. 30 May 2016 8, 5, p. 2432-2437 6 p.

    Research output: Contribution to journalArticle

  3. Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function

    Esteras, N., Dinkova-Kostova, A. T. & Abramov, A. Y. May 2016 In : Biological Chemistry. 397, 5, p. 383-400 18 p.

    Research output: Contribution to journalArticle

  4. Synthesis, molecular modeling and NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives

    Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K. 7 Apr 2016 In : Journal of Enzyme Inhibition and Medicinal Chemistry. p. 1-7 7 p.

    Research output: Contribution to journalArticle

  5. The heparan sulfate sulfotransferase 3-OST3A (HS3ST3A) is a novel tumor regulator and a prognostic marker in breast cancer

    Mao, X., Gauche, C., Coughtrie, M. W. H., Bui, C., Gulberti, S., Merhi-Soussi, F., Ramalanjaona, N., Bertin-Jung, I., Diot, A., Dumas, D., De Freitas Caires, N., Thompson, A. M., Bourdon, J-C., Ouzzine, M. & Fournel-Gigleux, S. 4 Apr 2016 In : Oncogene. 13 p.

    Research output: Contribution to journalArticle

  6. Making the invisible visible

    van Steensel, M. A. M. 1 Apr 2016 In : Seminars in Cell & Developmental Biology. 52, p. 58-65 8 p.

    Research output: Contribution to journalArticle

  7. Chemical constituents and NAD(P)H:Quinone oxidoreductase 1 (NQO1) inducer activity of Teucrium oliverianum Ging. ex Benth

    Shahat, A. A., Alsaid, M. S., Khan, J. A., Higgins, M. & Dinkova-Kostova, A. T. Apr 2016 In : Indian Journal of Traditional Knowledge. 15, 2, p. 232-236 5 p.

    Research output: Contribution to journalArticle

  8. Locally advanced basal cell carcinoma has a distinct methylation and transcriptomic profile

    Brinkhuizen, T., van Geel, M., Denil, S. L. I. J., De Meyer, T., Kelleners-Smeets, N. W. J., Lohuis, P. J. F. M., Hoebers, F. J. P., Winnepenninckx, V. J. L., van Steensel, M. A. M. & Mosterd, K. Apr 2016 In : Experimental Dermatology. 25, 4, p. 316-318 3 p.

    Research output: Contribution to journalLetter

  9. Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer

    Palmer, S., Litvinova, K., Dunaev, A., Fleming, S., McGloin, D. & Nabi, G. 7 Mar 2016 In : Biomedical Optics Express. 7, 4, p. 1193-2000 8 p.

    Research output: Contribution to journalArticle

  10. The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132

    Remenyi, J., Bajan, S., Fuller-Pace, F. V., Arthur, J. S. C. & Hutvagner, G. 7 Mar 2016 In : Scientific Reports. 6, 13 p., 22848

    Research output: Contribution to journalArticle

  11. Photodynamic diagnostic ureterorenoscopy: a valuable tool in the detection of upper urinary tract tumour

    Kata, S. G., Aboumarzouk, O. M., Zreik, A., Somani, B., Ahmad, S., Nabi, G., Buist, R., Goodman, C., Chlosta, P., Golabek, T. & Moseley, H. Mar 2016 In : Photodiagnosis and Photodynamic Therapy. 13, p. 255-260 6 p.

    Research output: Contribution to journalArticle

  12. A spontaneous increase in intracellular Ca2+ in metaphase II human oocytes in vitro can be prevented by drugs targeting ATP-sensitive K+ channels

    Fernandes, G., Dasai, N., Kozlova, N., Mojadadi, A., Gall, M., Drew, E., Barratt, E., Madamidola, O. A., Brown, S. G., Milne, A. M., Martins Da Silva, S. J., Whalley, K. M., Barratt, C. L. R. & Jovanovic, A. Feb 2016 In : Human Reproduction. 31, 2, p. 287-297 11 p.

    Research output: Contribution to journalArticle

  13. Hand dermatitis in construction workers: a lesson in genetic epidemiology

    Brown, S. J. Feb 2016 In : British Journal of Dermatology. 174, 2, p. 263-265 3 p.

    Research output: Contribution to journalArticle

  14. International Consortium on Mammographic Density: methodology and population diversity captured across 22 countries

    McCormack, V. A. , Burton, A. , dos-Santos-Silva, I. , Hipwell, J. H. , Dickens, C. , Salem, D. , Kamal, R. , Hartman, M. , Lee, C. P. L. , Chia, K-S. , Ozmen, V. , Aribal, M. E. , Flugelman, A. A. , Lajous, M. , Lopez-Riduara, R. , Rice, M. , Romieu, I. , Ursin, G. , Qureshi, S. & 37 others Ma, H., Lee, E., van Gils, C. H., Wanders, J. O. P., Vinayak, S., Ndumia, R., Allen, S., Vinnicombe, S., Moss, S., Won Lee, J., Kim, J., Pereira, A., Garmendia, M. L., Sirous, R., Sirous, M., Peplonska, B., Bukowska, A., Tamimi, R. M., Bertrand, K., Nagata, C., Kwong, A., Vachon, C., Scott, C., Perez-Gomez, B., Pollan, M., Maskarinec, G., Giles, G., Hopper, J., Stone, J., Rajaram, N., Teo, S-H., Mariapun, S., Yaffe, M. J., Schüz, J., Chiarelli, A. M., Linton, L. & Boyd, N. F. Feb 2016 In : Cancer Epidemiology. 40, p. 141-151 11 p.

    Research output: Contribution to journalArticle

  15. LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner

    Kramer, H. B., Lai, C-F., Patel, H., Periyasamy, M., Lin, M-L., Feller, S. M., Fuller-Pace, F. V., Meek, D. W., Ali, S. & Buluwela, L. 29 Jan 2016 In : Nucleic Acids Research. 44, 2, p. 582-594 13 p.

    Research output: Contribution to journalArticle

  16. NAD(P)H: Quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives

    Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A. 21 Jan 2016 In : Journal of Enzyme Inhibition and Medicinal Chemistry. 6 p.

    Research output: Contribution to journalArticle

  17. Rhodiola rosea L.: from golden root to green cell factories

    Marchev, A. S., Dinkova-Kostova, A. T., György, Z., Mirmazloum, I., Aneva, I. Y. & Georgiev, M. I. 13 Jan 2016 In : Phytochemistry Reviews. p. 1-22 22 p.

    Research output: Contribution to journalArticle

  18. Can angiotensin-converting enzyme inhibitors reduce the incidence, severity, and duration of radiation proctitis?

    Alashkham, A., Paterson, C., Rauchhaus, P. & Nabi, G. Jan 2016 In : International Journal of Radiation Oncology Biology Physics. 94, 1, p. 93-101 9 p.

    Research output: Contribution to journalArticle

  19. Detection of DCIS and reduced invasive interval cancers

    Evans, A. Jan 2016 In : Lancet Oncology. 17, 1, p. 14-15 2 p.

    Research output: Contribution to journalComment/debate

  20. Re: A proposal to standardize reporting units for fecal immunochemical tests for hemoglobin

    Fraser, C. G., Rapi, S. & Rubeca, T. Jan 2016 In : Journal of the National Cancer Institute. 108, 1, 2 p., djv312

    Research output: Contribution to journalLetter

  21. The use of the Rx spin label in orientation measurement on proteins, by EPR

    Stevens, M. A., McKay, J. E., Robinson, J. L. S., El Mkami, H., Smith, G. M. & Norman, D. G. 2016 In : Physical Chemistry Chemical Physics. 18, 8, p. 5799-5806 8 p.

    Research output: Contribution to journalArticle

  22. DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions

    Huang, W. , Thomas, B. , Flynn, R. A. , Gavzy, S. J. , Wu, L. , Kim, S. V. , Hall, J. A. , Miraldi, E. R. , Ng, C. P. , Rigo, F. , Meadows, S. , Montoya, N. R. , Herrera, N. G. , Domingos, A. I. , Rastinejad, F. , Myers, R. M. , Fuller-Pace, F. V. , Bonneau, R. , Chang, H. Y. & 2 others Acuto, O. & Littman, D. R. 24 Dec 2015 In : Nature. 528, 7583, p. 517-522 6 p.

    Research output: Contribution to journalArticle

  23. Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa

    Williams, H. L., Mansell, S., Alasmari, W., Brown, S. G., Wilson, S. M., Sutton, K. A., Miller, M. R., Lishko, P. V., Barratt, C. L. R., Publicover, S. J. & Martins da Silva, S. Dec 2015 In : Human Reproduction. 30, 12, p. 2737-2746 10 p.

    Research output: Contribution to journalArticle

  24. Activation status of the Pregnane X Receptor influences Vemurafenib availability in humanized mouse models

    MacLeod, A. K., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R. 1 Nov 2015 In : Cancer Research. 75, 21, p. 4573-4581 10 p.

    Research output: Contribution to journalArticle

  25. BRCA1 is required for maintenance of phospho-Chk1 and G2/M arrest during DNA cross-link repair in DT40 cells

    Draga, M., Madgett, E. B., Vandenberg, C. J., du Plessis, D., Kaufmann, A., Werler, P., Chakraborty, P., Lowndes, N. F. & Hiom, K. Nov 2015 In : Molecular and Cellular Biology. 35, 22, p. 3829-3840 12 p.

    Research output: Contribution to journalArticle

  26. Defining human pathways of drug metabolism in vivo through the development of a multiple humanized mouse model

    Scheer, N., Kapelyukh, Y., Rode, A., Oswald, S., Busch, D., McLaughlin, L. A., Lin, D., Henderson, C. J. & Wolf, C. R. Nov 2015 In : Drug Metabolism and Disposition. 43, 11, p. 1679-1690 12 p.

    Research output: Contribution to journalArticle

  27. Development of small-molecule Trypanosoma brucei N-myristoyltransferase inhibitors: discovery and optimisation of a novel binding mode

    Spinks, D., Smith, V., Thompson, S., Robinson, D. A., Luksch, T., Smith, A., Torrie, L. S., McElroy, S., Stojanovski, L., Norval, S., Collie, I. T., Hallyburton, I., Rao, B., Brand, S., Brenk, R., Frearson, J. A., Read, K. D., Wyatt, P. G. & Gilbert, I. H. Nov 2015 In : ChemMedChem. 10, 11, p. 1821-1836 16 p.

    Research output: Contribution to journalArticle

  28. Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

    Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D. Nov 2015 In : Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.

    Research output: Contribution to journalArticle

  29. The emerging role of Nrf2 in mitochondrial function

    Dinkova-Kostova, A. T. & Abramov, A. Y. Nov 2015 In : Free Radical Biology and Medicine. 88, Part B, p. 179-188 10 p.

    Research output: Contribution to journalArticle

  30. Trends in socio-economic inequalities in the Scottish diet: 2001-2009

    Barton, K. L., Wrieden, W. L., Sherriff, A., Armstrong, J. & Anderson, A. S. Nov 2015 In : Public Health Nutrition. 18, 16, p. 2970-2980 11 p.

    Research output: Contribution to journalArticle

  31. Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

    Matula, K., Collie-Duguid, E., Murray, G., Parikh, K., Grabsch, H., Tan, P., Lalwani, S., Garau, R., Ong, Y., Bain, G., Smith, A-D., Urquhart, G., Bielawski, J., Finnegan, M. & Petty, R. 22 Oct 2015 In : BMC Cancer. 15, 1, 14 p., 762

    Research output: Contribution to journalArticle

  32. Epidermal Growth Factor (EGFR) copy number aberrations in esophageal and gastro-esophageal junctional carcinoma

    Dahle-Smith, Å., Stevenson, D., Massie, D., Murray, G. I., Dutton, S. J., Roberts, C., Ferry, D., Osborne, A., Clark, C., Petty, R. D. & Miedzybrodzka, Z. 17 Oct 2015 In : Molecular Cytogenetics. 8, 9 p., 78

    Research output: Contribution to journalArticle

  33. APOBEC3B-mediated cytidine deamination is required for estrogen receptor action in breast cancer

    Periyasamy, M., Patel, H., Lai, C-F., Nguyen, V. T. M., Nevedomskaya, E., Harrod, A., Russell, R., Remenyi, J., Ochocka, A. M., Thomas, R. S., Fuller-Pace, F., Győrffy, B., Caldas, C., Navaratnam, N., Carroll, J. S., Zwart, W., Coombes, R. C., Magnani, L., Buluwela, L. & Ali, S. 6 Oct 2015 In : Cell Reports. 13, 1, p. 108-121 14 p.

    Research output: Contribution to journalArticle

  34. FLCN and AMPK confer resistance to hyperosmotic stress via remodeling of glycogen stores

    Possik, E., Ajisebutu, A., Manteghi, S., Gingras, M-C., Vijayaraghavan, T., Flamand, M., Coull, B., Schmeisser, K., Duchaine, T., van Steensel, M., Hall, D. H. & Pause, A. 6 Oct 2015 In : PLoS Genetics. 11, 10, 18 p., e1005520

    Research output: Contribution to journalArticle

  35. Mice lacking beta2-integrin function remain glucose tolerant in spite of insulin resistance, neutrophil infiltration and inflammation

    Meakin, P. J., Morrison, V. L., Sneddon, C. C., Savinko, T., Uotila, L., Jalicy, S. M., Gabriel, J. L., Kang, L., Ashford, M. L. J. & Fagerholm, S. C. 25 Sep 2015 In : PLoS ONE. 10, 9, 15 p., e0138872

    Research output: Contribution to journalArticle

  36. Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action

    Kostov, R. V., Knatko, E., McLaughlin, L., Henderson, C., Zheng, S., Huang, J. T-J., Honda, T. & Dinkova-Kostova, A. T. 25 Sep 2015 In : Biochemical and Biophysical Research Communications. 465, 3, p. 402-407 6 p.

    Research output: Contribution to journalArticle

  37. Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1-Nrf2 protein-protein interaction

    Bertrand, H. C., Schaap, M., Baird, L., Georgakopoulos, N. D., Fowkes, A., Thiollier, C., Kachi, H., Dinkova-Kostova, A. T. & Wells, G. 24 Sep 2015 In : Journal of Medicinal Chemistry. 58, 18, p. 7186-7194 9 p.

    Research output: Contribution to journalArticle

  38. Lysyl hydroxylase 3 localizes to epidermal basement membrane and Is reduced in patients with Recessive Dystrophic Epidermolysis Bullosa

    Watt, S. A., Dayal, J. H. S., Wright, S., Riddle, M., Pourreyron, C., McMillan, J. R., Kimble, R. M., Prisco, M., Gartner, U., Warbrick, E., McLean, W. H. I., Leigh, I. M., McGrath, J. A., Salas-Alanis, J. C., Tolar, J. & South, A. P. 18 Sep 2015 In : PLoS ONE. 10, 9, 15 p., e0137639

    Research output: Contribution to journalArticle

  39. A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial

    Harrison, E. F., Haines, R. H., Cowdell, F., Sach, T. H., Dean, T., Pollock, I., Burrows, N. P., Buckley, H., Batchelor, J., Williams, H. C., Lawton, S., Brown, S. J., Bradshaw, L. E., Ahmed, A., Montgomery, A. A., Mitchell, E. J. & Thomas, K. S. 2 Sep 2015 In : Trials. 16, 12 p., 390

    Research output: Contribution to journalArticle

  40. Giving structure to the biofilm matrix: an overview of individual strategies and emerging common themes

    Hobley, L., Harkins, C., MacPhee, C. E. & Stanley-Wall, N. R. 1 Sep 2015 In : FEMS Microbiology Reviews. 39, 5, p. 649-669 21 p.

    Research output: Contribution to journalArticle

  41. Is photodynamic diagnostic flexible ureterorenoscopy suitable for a patient presenting with chronic actinic dermatitis?

    Valentine, R., Kata, S., Ibbotson, S., Nabi, G. & Moseley, H. Sep 2015 In : Photodermatology, Photoimmunology & Photomedicine. 31, 5, p. 279-281 3 p.

    Research output: Contribution to journalLetter

  42. Novel CARD11 mutations in human cutaneous squamous cell carcinoma lead to aberrant NF-κB regulation

    Watt, S. A., Purdie, K. J., den Breems, N. Y., Dimon, M., Arron, S. T., McHugh, A. T., Xue, D. J., Dayal, J. H. S., Proby, C. M., Harwood, C. A., Leigh, I. M. & South, A. P. Sep 2015 In : American Journal of Pathology. 185, 9, p. 2354-2363 10 p.

    Research output: Contribution to journalArticle

  43. Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection

    Yelumalai, S., Yeste, M., Jones, C., Amdani, S. N., Kashir, J., Mounce, G., Martins Da Silva, S. J., Barratt, C. L., McVeigh, E. & Coward, K. Sep 2015 In : Fertility and Sterility. 104, 3, p. 561-568.e4 12 p.

    Research output: Contribution to journalArticle

  44. Synthesis of carbohydrate capped silicon nanoparticles and their reduced cytotoxicity, in vivo toxicity, and cellular uptake

    Ahire, J. H., Behray, M., Webster, C. A., Wang, Q., Sherwood, V., Saengkrit, N., Ruktanonchai, U., Woramongkolchai, N. & Chao, Y. 26 Aug 2015 In : Advanced Healthcare Materials. 4, 12, p. 1877-1886 10 p.

    Research output: Contribution to journalArticle

  45. The fanconi anemia DNA repair pathway is regulated by an interaction between ubiquitin and the E2-like fold domain of FANCL

    Miles, J. A., Frost, M. G., Carroll, E., Rowe, M. L., Howard, M. J., Sidhu, A., Chaugule, V. K., Alpi, A. F. & Walden, H. 21 Aug 2015 In : Journal of Biological Chemistry. 290, 34, p. 20995-21006 12 p.

    Research output: Contribution to journalArticle

  46. Selective expression of the MAPK phosphatase Dusp9/MKP-4 in mouse plasmacytoid dendritic cells and regulation of IFNβ production1

    Niedzielska, M., Raffi, F. A. M., Tel, J., Muench, S., Jozefowski, K., Alati, N., Lahl, K., Mages, J., Billmeier, U., Schiemann, M., Appelt, U. K., Wirtz, S., Sparwasser, T., Hochrein, H., Figdor, C. G., Keyse, S. M. & Lang, R. 15 Aug 2015 In : Journal of Immunology. 195, 4, p. 1753-1762 10 p.

    Research output: Contribution to journalArticle

  47. The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression

    Zhang, Y., Li, S., Xiang, Y., Qiu, L., Zhao, H. & Hayes, J. D. 13 Aug 2015 In : Scientific Reports. 5, 30 p., 12983

    Research output: Contribution to journalArticle

  48. The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic

    O'Connell, M. A. & Hayes, J. D. 3 Aug 2015 In : Biochemical Society Transactions. 43, 4, p. 687-689 3 p.

    Research output: Contribution to journalArticle

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