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Division of Cardiovascular & Diabetes Medicine

  1. A systematic review of the prevalence of mildly abnormal liver function tests and associated health outcomes

    Radcke, S., Dillon, J. F. & Murray, A. L. Jan 2015 In : European Journal of Gastroenterology & Hepatology. 27, 1, p. 1-7 7 p.

    Research output: Contribution to journalArticle

  2. The development and deployment of integrated electronic care records in a regional adult and paediatric cystic fibrosis unit

    Peckham, D., Etherington, C., White, H., Mehta, A., Shaw, N., Morton, A., Pollard, K., Lee, T., Brownlee, K., Taylor, J., Whitaker, P. & Conway, S. Dec 2014 In : Journal of Cystic Fibrosis. 13, 6, p. 681-686 6 p.

    Research output: Contribution to journalArticle

  3. The inverse agonist propranolol confers no corticosteroid-sparing activity in mild-to-moderate persistent asthma

    Anderson, W. J., Short, P. M., Williamson, P. A., Manoharan, A. & Lipworth, B. J. Dec 2014 In : Clinical Science. 127, 11, p. 635-643 9 p.

    Research output: Contribution to journalArticle

  4. Cardiovascular risk associated with sodium-containing medicines

    Wei, L., Mackenzie, I. S., MacDonald, T. M. & George, J. Nov 2014 In : Expert Opinion on Drug Safety. 13, 11, p. 1515-1523 9 p.

    Research output: Contribution to journalArticle

  5. Heterozygous SOD2 Deletion Impairs Glucose-Stimulated Insulin Secretion, but not Insulin Action in High Fat-Fed Mice

    Kang, L., Dai, C., Lustig, M. E., Bonner, J. S., Mayes, W. H., Mokshagundam, S., James, F. D., Thompson, C. S., Lin, C-T., Perry, C. G. R., Anderson, E. J., Neufer, P. D., Wasserman, D. H. & Powers, A. C. Nov 2014 In : Diabetes. 63, 11, p. 3699-3710 12 p.

    Research output: Contribution to journalArticle

  6. Male fertility and infertility

    Ramalingam, M., Kini, S. & Mahmood, T. Nov 2014 In : Obstetrics, Gynaecology and Reproductive Medicine. 24, 11, p. 326-332 7 p.

    Research output: Contribution to journalArticle

  7. Upregulation of cardioprotective SUR2A by sub-hypoxic drop in oxygen

    Mohammed Abdul, K. S., Jovanović, S., Sukhodub, A., Du, Q. & Jovanović, A. Nov 2014 In : Biochimica et Biophysica Acta. Molecular Cell Research. 1843, 11, p. 2424-2431 8 p.

    Research output: Contribution to journalArticle

  8. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

    Morris, A. & 103 others Postmus, I., Trompet, S., Deshmukh, H. A., Barnes, M. R., Li, X., Warren, H. R., Chasman, D. I., Zhou, K., Arsenault, B. J., Donnelly, L. A., Wiggins, K. L., Avery, C. L., Griffin, P., Feng, Q., Taylor, K. D., Li, G., Evans, D. S., Smith, A. V., de Keyser, C. E., Johnson, A. D., de Craen, A. J. M., Stott, D. J., Buckley, B. M., Ford, I., Westendorp, R. G. J., Eline Slagboom, P., Sattar, N., Munroe, P. B., Sever, P., Poulter, N., Stanton, A., Shields, D. C., O'Brien, E., Shaw-Hawkins, S., Ida Chen, Y-D., Nickerson, D. A., Smith, J. D., Pierre Dubé, M., Matthijs Boekholdt, S., Kees Hovingh, G., Kastelein, J. J. P., McKeigue, P. M., Betteridge, J., Neil, A., Durrington, P. N., Doney, A., Carr, F., McCarthy, M. I., Groop, L., Ahlqvist, E., Bis, J. C., Rice, K., Smith, N. L., Lumley, T., Whitsel, E. A., Stürmer, T., Boerwinkle, E., Ngwa, J. S., O'Donnell, C. J., Vasan, R. S., Wei, W-Q., Wilke, R. A., Liu, C-T., Sun, F., Guo, X., Heckbert, S. R., Post, W., Sotoodehnia, N., Arnold, A. M., Stafford, J. M., Ding, J., Herrington, D. M., Kritchevsky, S. B., Eiriksdottir, G., Launer, L. J., Harris, T. B., Chu, A. Y., Giulianini, F., MacFadyen, J. G., Barratt, B. J., Nyberg, F., Stricker, B. H., Uitterlinden, A. G., Hofman, A., Rivadeneira, F., Emilsson, V., Franco, O. H., Ridker, P. M., Gudnason, V., Liu, Y., Denny, J. C., Ballantyne, C. M., Rotter, J. I., Adrienne Cupples, L., Psaty, B. M., Palmer, C. N. A., Tardif, J-C., Colhoun, H. M., Hitman, G., Krauss, R. M., Wouter Jukema, J., Caulfield, M. J. & Welcome Trust Case Control Consortium 28 Oct 2014 In : Nature Communications. 5, 10 p.5068

    Research output: Contribution to journalArticle

  9. Phenotype standardisation of angioedema in the head and neck region caused by agents acting on the angiotensin system

    Wadelius, M., Marshall, S. E., Islander, G., Nordang, L., Karawajczyk, M., Yue, Q-Y., Terreehorst, I., Baranova, E. V., Hugosson, S., Sköldefors, K., Pirmohamed, M., Maitland van der Zee, A-H., Alfirevic, A., Hallberg, P. & Palmer, C. N. A. Oct 2014 In : Clinical Pharmacology & Therapeutics. 96, 4, p. 477-481

    Research output: Contribution to journalScientific review

  10. Phenotype standardization for statin-induced myotoxicity

    Alfirevic, A., Neely, D., Armitage, J., Chinoy, H., Cooper, R. G., Laaksonen, R., Carr, D. F., Bloch, K. M., Fahy, J., Hanson, A., Yue, Q. Y., Wadelius, M., Maitland-van Der Zee, A. H., Voora, D., Psaty, B. M., Palmer, C. N. A. & Pirmohamed, M. Oct 2014 In : Clinical Pharmacology & Therapeutics. 96, 4, p. 470-476 7 p.

    Research output: Contribution to journalArticle

  11. The potential role of direct and indirect bronchial challenge testing to identify overtreatment of community managed asthma

    Manoharan, A., Lipworth, B., Craig, E. & Jackson, C. Oct 2014 In : Clinical and Experimental Allergy. 44, 10, p. 1240-1245 6 p.

    Research output: Contribution to journalArticle

  12. The serum proteome of nonalcoholic fatty liver disease: A multimodal approach to discovery of biomarkers of nonalcoholic steatohepatitis

    Miller, M. H., Walsh, S. V., Atirh, A., Huang, J. T-J., Ferguson, M. A. J. & Dillon, J. F. Oct 2014 In : Journal of Gastroenterology and Hepatology. 29, 10, p. 1839-1847 9 p.

    Research output: Contribution to journalArticle

  13. Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in Europeans: the MORGAM Prospective Cohort Project

    Vishram, J. K. K. , Borglykke, A. , Andreasen, A. H. , Jeppesen, J. , Ibsen, H. , Jørgensen, T. , Palmieri, L. , Giampaoli, S. , Donfrancesco, C. , Kee, F. , Mancia, G. , Cesana, G. , Kuulasmaa, K. , Salomaa, V. , Sans, S. , Ferrieres, J. , Dallongeville, J. , Söderberg, S. , Arveiler, D. , Wagner, A. & 4 others Tunstall-Pedoe, H., Drygas, W., Olsen, M. H. & on behalf of the MORGAM Project 22 Sep 2014 In : PLoS ONE. 9, 9, 12 p.e107294

    Research output: Contribution to journalArticle

  14. High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis

    Chin, C. W. L., Shah, A. S. V., McAllister, D. A., Cowell, S. J., Alam, S., Langrish, J. P., Strachan, F. E., Hunter, A. L., Maria Choy, A., Lang, C. C., Walker, S., Boon, N. A., Newby, D. E., Mills, N. L. & Dweck, M. R. 7 Sep 2014 In : European Heart Journal. 35, 34, p. 2312-2321 10 p.

    Research output: Contribution to journalArticle

  15. ACE inhibitors, statins and thiazides: no association with change in grip strength among community dwelling older men and women from the Hertfordshire Cohort Study

    Witham, M. D., Syddall, H. E., Dennison, E., Cooper, C., McMurdo, M. E. T. & Sayer, A. A. Sep 2014 In : Age and Ageing. 43, 5, p. 661-666 6 p.

    Research output: Contribution to journalArticle

  16. Bronchiectasis trials: losing the battle but winning the war?

    Chalmers, J. D. Sep 2014 In : The Lancet Respiratory Medicine. 2, 9, p. 679-681 3 p.

    Research output: Contribution to journalArticle

  17. Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis

    Ford, J. A., MacLennan, G. S., Avenell, A., Bolland, M., Grey, A., Witham, M. & for the RECORD Trial Group Sep 2014 In : American Journal of Clinical Nutrition. 100, 3, p. 746-755 10 p.

    Research output: Contribution to journalArticle

  18. Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains

    Kneuper, H., Cao, Z. P., Twomey, K. B., Zoltner, M., Jäger, F., Cargill, J. S., Chalmers, J., van der Kooi-Pol, M. M., van Dijl, J. M., Ryan, R. P., Hunter, W. N. & Palmer, T. Sep 2014 In : Molecular Microbiology. 93, 5, p. 928-943 15 p.

    Research output: Contribution to journalArticle

  19. The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

    Patel, K., Foretz, M., Marion, A., Campbell, D. G., Gourlay, R., Boudaba, N., Tournier, E., Titchenell, P., Peggie, M., Deak, M., Wan, M., Kaestner, K. H., Göransson, O., Viollet, B., Gray, N. S., Birnbaum, M. J., Sutherland, C. & Sakamoto, K. 4 Aug 2014 In : Nature Communications. 5, 4535

    Research output: Contribution to journalArticle

  20. Retinal imaging as a source of biomarkers for diagnosis, characterization and prognosis of chronic illness or long-term conditions

    MacGillivray, T. J., Trucco, E., Cameron, J. R., Dhillon, B., Houston, J. G. & van Beek, E. J. R. Aug 2014 In : British Journal of Radiology. 87, 1040, 16 p.20130832

    Research output: Contribution to journalArticle

  21. The contribution of educational class in improving accuracy of cardiovascular risk prediction across European regions: the MORGAM Project Cohort Component

    Ferrario, M. M. , Veronesi, G. , Chambless, L. E. , Tunstall-Pedoe, H. , Kuulasmaa, K. , Salomaa, V. , Borglykke, A. , Hart, N. , Söderberg, S. , Cesana, G. , Jørgensen, T. , Agger, C. , Juolevi, A. , Vartiainen, E. , Jousilahti, P. , Cepaitis, Z. , Haukijärvi, A. , Joseph, B. , Kulathinal, S. , Niemelä, M. & 74 others Saarela, O., Ducimetière, P., Bingham, A., Arveiler, D., Haas, B., Wagner, A., Ferrières, J., Ruidavets, J-B., Bongard, V., Amouyel, P., Montaye, M., Dallongeville, J., Döring, A., Wichmann, E., Fornari, C., Sega, R., Mancia, G., Facchetti, R., Vanuzzo, D., Pilotto, L., Picco, F., Mattiussi, F., Gigante, S., Tamosiunas, A., Domarkiene, S., Rastenyte, D., Bernotiene, G., Radisauskas, R., Baceviciene, M., Luksiene, D., Malinauskiene, V., Bernotaite, L., Pajak, A., Kawalec, E., Broda, G., Kurjata, P., Rywik, S. L., Polakowska, M., Pytlak, A., Nikitin, Y., Malyutina, S., Gafarov, V., Feigin, V., Siminova, G., Voevoda, M., Vinogradova, T., Nasonova, N., Veriovkin, E., Eliasson, M., Stegmayr, B., Eriksson, M., Asplund, K., Kee, F., Evans, A., Yarnell, J., Gardner, E., Woodward, M., Evans, A., Cashman, S., Evans, A., Blankenberg, S., Kee, F., Palotie, A., Perola, M., Peters, A., Salomaa, V., Tregouet, D., Asplund, K., Cambien, F., Tiret, L., Peltonen, L., Shields, D., Stegmayr, B. & Wiklund, P-G. Aug 2014 In : Heart. 100, 15, p. 1179-1187 9 p.

    Research output: Contribution to journalArticle

  22. Proteomic and genomic studies of non-alcoholic fatty liver disease - clues in the pathogenesis

    Lim, J. W., Dillon, J. & Miller, M. 14 Jul 2014 In : World Journal of Gastroenterology . 20, 26, p. 8325-8340 16 p.

    Research output: Contribution to journalArticle

  23. Loss-of-function mutations in APOC3, triglycerides, and coronary disease

    TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung, and Blood Institute 3 Jul 2014 In : New England Journal of Medicine. 371, 1, p. 22-31 10 p.

    Research output: Contribution to journalArticle

  24. CFTR functional measurements in human models for diagnosis, prognosis and personalized therapy: report on the pre-conference meeting to the 11th ECFS Basic Science Conference, Malta, 26-29 March 2014

    Beekman, J. M., Sermet-Gaudelus, I., de Boeck, K., Gonska, T., Derichs, N., Mall, M. A., Mehta, A., Martin, U., Drumm, M. & Amaral, M. D. Jul 2014 In : Journal of Cystic Fibrosis. 13, 4, p. 363-372 10 p.

    Research output: Contribution to journalArticle

  25. Intergenerational transmission of postpartum haemorrhage risk: analysis of two Scottish birth cohorts

    Sharp, G. C., Saunders, P. T. K., Greene, S. A., Morris, A. D. & Norman, J. E. Jul 2014 In : American Journal of Obstetrics and Gynecology. 211, 1, p. 51.e1-51.e7 7 p.

    Research output: Contribution to journalArticle

  26. Thrombocytosis is associated with increased short and long term mortality after exacerbation of chronic obstructive pulmonary disease: a role for antiplatelet therapy?

    Harrison, M. T., Short, P., Williamson, P. A., Singanayagam, A., Chalmers, J. D. & Schembri, S. Jul 2014 In : Thorax. 69, 7, p. 609-615 7 p.

    Research output: Contribution to journalArticle

  27. Wireless MR tracking of interventional devices using phase-field dithering and projection reconstruction

    Rube, M. A., Holbrook, A. B., Cox, B. F., Houston, J. G. & Melzer, A. Jul 2014 In : Magnetic Resonance Imaging. 32, 6, p. 693-701 9 p.

    Research output: Contribution to journalArticle

  28. Targeted genetic testing for familial hypercholesterolaemia using next generation sequencing: a population-based study

    Norsworthy, P. J., Vandrovcova, J., Thomas, E. R. A., Campbell, A., Kerr, S. M., Biggs, J., Game, L., Soutar, A. K., Smith, B. H., Dominiczak, A. F., Porteous, D. J., Morris, A. D., Generation Scotland & Aitman, T. J. 23 Jun 2014 In : BMC Medical Genetics. 15, 7 p.70

    Research output: Contribution to journalArticle

  29. Neuronal deletion of GSK3beta increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2

    Liz, M. A., Mar, F. M., Santos, T. E., Pimentel, H. I., Marques, A. M., Morgado, M. M., Vieira, S., Sousa, V. F., Pemble, H., Wittmann, T., Sutherland, C., Woodgett, J. R. & Sousa, M. M. 12 Jun 2014 In : BMC Biology. 12, 47

    Research output: Contribution to journalArticle

  30. The phosphorylation of endogenous Nedd4-2 In Na+-absorbing human airway epithelial cells

    Ismail, N. A. S., Baines, D. L. & Wilson, S. M. 5 Jun 2014 In : European Journal of Pharmacology. 732, p. 32-42 11 p.

    Research output: Contribution to journalArticle

  31. Prediction of liver disease in patients whose liver function tests have been checked in primary care: model development and validation using population-based observational cohorts

    McLernon, D. J., Donnan, P. T., Sullivan, F. M., Roderick, P., Rosenberg, W. M., Ryder, S. D. & Dillon, J. F. 2 Jun 2014 In : BMJ Open. 4, 6, 10 p.e004837

    Research output: Contribution to journalArticle

  32. 112 B-type natriuretic peptide is associated with future rise in Lv mass in optimally treated primary prevention population

    Nadir, A., Gandy, S. & Struthers, A. Jun 2014 In : Heart (British Cardiac Society). 100 , suppl 3, p. A64-A65 2 p.

    Research output: Contribution to journalMeeting abstract

  33. 60 insulin resistance is associated with all-cause mortality and accelerates the risk of progression to diabetes in non-diabetic heart failure patients

    Mohan, M., Deshmukh, H., Maria Choy, A. & Lang, C. Jun 2014 In : Heart. 100 , s3, p. A34 1 p.

    Research output: Contribution to journalMeeting abstract

  34. Discovering new biomarkers for predicting treatment response in heart failure using plasma proteomics

    Huy, T. C., Quinn, P. A., Sandhu, J. K., Voors, A. A., Parry, H., Lang, C. C., Jones, D. J. L. & Ng, L. L. Jun 2014 In : Heart (British Cardiac Society). 100 , Suppl 3, p. A30

    Research output: Contribution to journalMeeting abstract

  35. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium

    Koivula, R. W. , Heggie, A. , Barnett, A. , Cederberg, H. , Hansen, T. H. , Koopman, A. D. , Ridderstråle, M. , Rutters, F. , Vestergaard, H. , Gupta, R. , Herrgård, S. , Heymans, M. W. , Perry, M. H. , Rauh, S. , Siloaho, M. , Teare, H. J. A. , Thorand, B. , Bell, J. , Brunak, S. , Frost, G. & 14 others Jablonka, B., Mari, A., McDonald, T. J., Dekker, J. M., Hansen, T., Hattersley, A., Laakso, M., Pedersen, O., Koivisto, V., Ruetten, H., Walker, M., Pearson, E., Franks, P. W. & DIRECT Consortium Jun 2014 In : Diabetologia. 57, 6, p. 1132-1142 11 p.

    Research output: Contribution to journalArticle

  36. Effectiveness of newspaper advertising for patient recruitment into a clinical trial

    Hapca, A., Jennings, C. G., Wei, L., Wilson, A., MacDonald, T. M. & Mackenzie, I. S. Jun 2014 In : British Journal of Clinical Pharmacology. 77, 6, p. 1064-1072 9 p.

    Research output: Contribution to journalArticle

  37. Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis

    Zhou, K., Donnelly, L., Yang, J., Li, M., Deshmukh, H., Van Zuydam, N., Ahlqvist, E., Spencer, C. C., Groop, L., Morris, A. D., Colhoun, H. M., Sham, P. C., McCarthy, M. I., Palmer, C. N. A. & Pearson, E. R. Jun 2014 In : The Lancet Diabetes and Endocrinology. 2, 6, p. 481-487 7 p.

    Research output: Contribution to journalArticle

  38. Preventing arterial catheter-associated bloodstream infections: common sense and chlorhexidine

    Chalmers, J. D. & Aliberti, S. Jun 2014 In : Critical Care Medicine. 42, 6, p. 1533-1534 2 p.

    Research output: Contribution to journalArticle

  39. Renal artery stenosis-when to screen, what to stent?

    Jennings, C. G., Houston, J. G., Severn, A., Bell, S., Mackenzie, I. S. & MacDonald, T. M. Jun 2014 In : Current Atherosclerosis Reports. 16, 6, 9 p.416

    Research output: Contribution to journalArticle

  40. Review article: 2014 UK consensus guidelines - hepatitis C management and direct-acting anti-viral therapy

    Miller, M. H., Agarwal, K., Austin, A., Brown, A., Barclay, S. T., Dundas, P., Dusheiko, G. M., Foster, G. R., Fox, R., Hayes, P. C., Leen, C., Millson, C., Ryder, S. D., Tait, J., Ustianowski, A. & Dillon, J. F. Jun 2014 In : Alimentary Pharmacology & Therapeutics. 39, 12, p. 1363-1375 13 p.

    Research output: Contribution to journalArticle

  41. Review article: 2014 UK consensus guidelines - hepatitis C management and direct-acting anti-viral therapy

    Miller, M. H., Agarwal, K., Austin, A., Brown, A., Barclay, S. T., Dundas, P., Dusheiko, G. M., Foster, G. R., Fox, R., Hayes, P. C., Leen, C., Millson, C., Ryder, S. D., Tait, J., Ustianowski, A. & Dillon, J. F. Jun 2014 In : Alimentary Pharmacology & Therapeutics. 39, 12, p. 1363-1375 13 p.

    Research output: Contribution to journalArticle

  42. A world without hepatitis C

    Ryder, S. & Dillon, J. 9 May 2014 In : Health Service Journal. 124, 6397, p. 21-23 3 p.

    Research output: Contribution to journalArticle

  43. Attendance at specialist hepatitis clinics and initiation of antiviral treatment among persons chronically infected with hepatitis C: examining the early impact of Scotland's Hepatitis C Action Plan

    Mcdonald, S. A., Hutchinson, S. J., Innes, H. A., Allen, S., Bramley, P., Bhattacharyya, D., Carman, W., Dillon, J. F., Fox, R., Fraser, A., Goldberg, D. J., Kennedy, N., Mills, P. R., Morris, J., Stanley, A. J., Wilks, D. & Hayes, P. C. May 2014 In : Journal of Viral Hepatitis. 21, 5, p. 366-376 11 p.

    Research output: Contribution to journalArticle

  44. Defining severity in non-cystic fibrosis bronchiectasis

    Poppelwell, L. & Chalmers, J. D. Apr 2014 In : Expert Review of Respiratory Medicine. 8, 2, p. 249-62 14 p.

    Research output: Contribution to journalArticle

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