Medical Research Institute

Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasis

Chalmers, J. D. & Hill, A. T. Aug-2013 In : Molecular Immunology. 55, 1, p. 27-34, 8 p.

Research output: Contribution to journal › Article

Evidence that Cytochrome b5 and Cytochrome b5 Reductase Can Act as Sole Electron Donors to the Hepatic Cytochrome P450 System

Henderson, C. J., McLaughlin, L. A. & Wolf, C. R. Jun-2013 In : Molecular Pharmacology. 83, 6, p. 1209-1217, 9 p.

Research output: Contribution to journal › Article

Oesophageal bacterial biofilm changes in gastro-oesophageal reflux disease, Barrett's and oesophageal carcinoma: association or causality?

Blackett, K. L., Siddhi, S. S., Cleary, S., Steed, H., Miller, M. H., Macfarlane, S., Macfarlane, G. T. & Dillon, J. F. Jun-2013 In : Alimentary Pharmacology & Therapeutics. 37, 11, p. 1084-1092, 9 p.

Research output: Contribution to journal › Article

Can pragmatic trials help us better understand chronic pain and improve treatment?

Rowbotham, M. C., Gilron, I., Glazer, C., Rice, A. S. C., Smith, B. H., Stewart, W. F. & Wasan, A. D. May-2013 In : PAIN. 154, 5, p. 643-646, 4 p.

Research output: Contribution to journal › Article

Effects of antibiotics on bacterial species composition and metabolic activities in chemostats containing defined populations of human gut microorganisms

Newton, D. F., Macfarlane, S. & Macfarlane, G. T. May-2013 In : Antimicrobial Agents and Chemotherapy. 57, 5, p. 2016-2025, 10 p.

Research output: Contribution to journal › Article

Host microRNA molecular signatures associated with human H1N1 and H3N2 influenza A viruses reveal an unanticipated antiviral activity for miR-146a

Terrier, O., Textoris, J., Carron, C., Marcel, V., Bourdon, J-C. & Rosa-Calatrava, M. May-2013 In : Journal of General Virology. 94, 5, p. 985-95, 11 p.

Research output: Contribution to journal › Article

Laparoscopic Surgical Skills are Significantly Improved by the Use of a Portable Laparoscopic Simulator: Results of a Randomized Controlled Trial

Johnston, T. J., Tang, B., Alijani, A., Tait, I., Steele, R. J., Ker, J., Nabi, G. & Surgical Simulation Group at the University of Dundee May-2013 In : World Journal of Surgery. 37, 5, p. 957-964, 8 p.

Research output: Contribution to journal › Article

Neuropathic pain in the community: more under-treated than refractory?

Torrance, N., Ferguson, J. A., Afolabi, E., Bennett, M. I., Serpell, M. G., Dunn, K. M. & Smith, B. H. May-2013 In : PAIN. 154, 5, p. 690–699, 10 p.

Research output: Contribution to journal › Article

Real-time RT-PCR threshold cycles value for Kir6.1 from the blood correlates with parameters of vascular function: a potential for the vascular function biomarker?

Khan, F., Choong, W. L., Du, Q. & Jovanovic, A. May-2013 In : Biomarkers. 18, 3, p. 221-229, 9 p.

Research output: Contribution to journal › Article

Vancomycin or metronidazole in patients with primary sclerosing cholangitis?

Paterson, J. C. M. & Dillon, J. F. May-2013 In : Alimentary Pharmacology & Therapeutics. 37, 9, p. 915-915, 1 p.

Research output: Contribution to journal › Comment/debate

Tumour Cell Labelling by Magnetic Nanoparticles with Determination of Intracellular Iron Content and Spatial Distribution of the Intracellular Iron

Wang, Z. & Cuschieri, A. 26-Apr-2013 In : International Journal of Molecular Sciences. 14, 5, p. 9111-9125, 15 p.

Research output: Contribution to journal › Article

Schizophrenia is associated with excess multiple physical-health comorbidities but low levels of recorded cardiovascular disease in primary care: cross-sectional study

Smith, D. J., Langan, J., McLean, G., Guthrie, B. & Mercer, S. W. 17-Apr-2013 In : BMJ Open. 3, 4, e002808

Research output: Contribution to journal › Article

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Berndt, S. I. , Jacobs, K. B. , Wang, Z. , Gustafsson, S. , Ingelsson, E. , Fall, T. , Grönberg, H. , Hall, P. , Magnusson, P. K. , Pedersen, N. , Pawitan, Y. , Mägi, R. , Randall, J. C. , Prokopenko, I. , McCarthy, M. I. , Fischer, K. , Milani, L. , Ganna, A. , Wheeler, E. , Kanoni, S. & 301 others Edkins, S., Hunt, S. E., Shin, S-Y., Stirrups, K., Deloukas, P., Feitosa, M. F., Kraja, A. T., Province, M. A., Borecki, I. B., Justice, A. E., Monda, K. L., North, K. E., Croteau-Chonka, D. C., Mohlke, K. L., Day, F. R., Luan, J., Zhao, J. H., Wareham, N. J., Esko, T., Perola, M., Mihailov, E., Metspalu, A., Ferreira, T., Min, J. L., Lindgren, C. M., Gentilini, D., Di Blasio, A. M., Jackson, A. U., Bragg-Gresham, J. L., Abecasis, G. R., Boehnke, M., Vedantam, S., Hirschhorn, J. N., Willer, C. J., Winkler, T. W., Wood, A. R., Frayling, T., Workalemahu, T., Franks, P. W., Qi, L., Hunter, D., Hu, Y-J., Lee, S. H., Liang, L., Lin, D-Y., Neale, B. M., Thorleifsson, G., Steinthorsdottir, V., Yang, J., Medland, S. E., Montgomery, G. W., Martin, N. G., Albrecht, E., Gieger, C., Amin, N., Cadby, G., Palmer, L. J., den Heijer, M., Eklund, N., Kristiansson, K., Goel, A., Farrall, M., Ripatti, S., Watkins, H., Hottenga, J-J., Willemsen, G., Boomsma, D. I., Huffman, J. E., Hayward, C., Vitart, V., Wright, A. F., Jarick, I., Johansson, A., Johnson, T., Munroe, P. B., Caulfield, M. J., Kleber, M. E., König, I. R., Kutalik, Z., Marek, D., Lamina, C., Lecoeur, C., Skrobek, B., Froguel, P., Meyre, D., Li, G., Mangino, M., Soranzo, N., Spector, T. D., McArdle, W. L., Medina-Gomez, C., Peters, M. J., Estrada, K., Rivadeneira, F., van Meurs, J. B. J., Witteman, J. C. M., Hofman, A., Uitterlinden, A. G., van Duijn, C. M., Zillikens, M. C., Müller-Nurasyid, M., Ngwa, J. S., Cupples, L. A., Nolte, I. M., Paternoster, L., Evans, D. M., Pechlivanis, S., Pütter, C., Jöckel, K-H., Scherag, A., Surakka, I., Palotie, A., Widén, E., Preuss, M., Rose, L. M., Shi, J., Chanock, S. J., Shungin, D., Smith, A. V., Gudnason, V., Stefansson, K., Thorsteinsdottir, U., Strawbridge, R. J., Hamsten, A., Teumer, A., Homuth, G., Trip, M. D., Tyrer, J., Van Vliet-Ostaptchouk, J. V., Van der Klauw, M. M., Wolffenbuttel, B. H. R., Bruinenberg, M., Stolk, R. P., Snieder, H., Vandenput, L., Lorentzon, M., Waite, L. L., Absher, D., Ohlsson, C., Asselbergs, F. W., Atalay, M., Attwood, A. P., Ouwehand, W. H., Balmforth, A. J., Basart, H., Hovingh, K. G., Beilby, J., Bonnycastle, L. L., Chines, P. S., Collins, F. S., Narisu, N., Swift, A. J., Brambilla, P., Campbell, H., Rudan, I., Wild, S. H., Wilson, J. F., Chasman, D. I., Ridker, P. M., Connell, J. M., Cookson, W. O., Moffatt, M. F., de Faire, U., de Vegt, F., Dei, M., Sanna, S., Dimitriou, M., Theodoraki, E. V., Dedoussis, G. V., Ferrario, M. M., Ferrières, J., Franke, L., Frau, F., Gejman, P. V., Sanders, A. R., Grallert, H., Hall, A. S., Hartikainen, A-L., Heard-Costa, N. L., Heath, A. C., Madden, P. A., Hebebrand, J., Hinney, A., Hu, F. B., Hyppönen, E., Power, C., Iribarren, C., Jansson, J-O., Jula, A., Kähönen, M., Kathiresan, S., Kee, F., Khaw, K-T., Kivimäki, M., Kumari, M., Langenberg, C., Hingorani, A., Koenig, W., Kuulasmaa, K., Virtamo, J., Salomaa, V., Kuusisto, J., Laakso, M., Laitinen, J. H., Lakka, T. A., Ong, K. K., Loos, R. J. F., Launer, L. J., Harris, T. B., Lind, L., Lindström, J., Liu, J., Liuzzi, A., Lokki, M-L., Manunta, P., März, W., Leach, I. M., van der Harst, P., McKnight, B., Mooser, V., Mühleisen, T. W., Musk, A. W., Navis, G., Nicholson, G., Nohr, E. A., Wong, A., Kuh, D., Oostra, B. A., Palmer, C. N. A., Morris, A. D., Radhakrishnan, A., Barroso, I., Peden, J. F., Peters, A., Illig, T., Thorand, B., Polasek, O., Pouta, A., Pramstaller, P. P., Rendon, A., Sambrook, J. G., Stephens, J. C., Raitakari, O., Saaristo, T. E., Saramies, J., Schipf, S., Schreiber, S., Schunkert, H., Erdmann, J., Signorini, S., Sinisalo, J., Nieminen, M. S., Stančáková, A., Stark, K., Hengstenberg, C., Stumvoll, M., Tönjes, A., Tregouet, D-A., Tremoli, E., Vermeulen, S. H., Kiemeney, L. A., Viikari, J., Waeber, G., Vollenweider, P., Winkelmann, B. R., Amouyel, P., Boehm, B. O., Boerwinkle, E., Cusi, D., Eriksson, J. G., Gyllensten, U., Hicks, A. A., Hveem, K., Jarvelin, M-R., Keinanen-Kiukaanniemi, S. M., Lehtimäki, T., Levinson, D. F., Njølstad, I., Oldehinkel, A. J., Penninx, B., Psaty, B. M., Rauramaa, R., Samani, N. J., Sørensen, T. I. A., Tuomilehto, J., Uusitupa, M., Wallaschofski, H., Wichmann, H-E., Heid, I. M., Assimes, T. L., Fox, C. S., Groop, L. C., Haritunian, T., Kaplan, R. C., Karpe, F., O'Connell, J. R., Schadt, E. E., Schlessinger, D., Strachan, D. P., Visscher, P. M. & Speliotes, E. K. 7-Apr-2013 In : Nature Genetics.

Research output: Contribution to journal › Article

Pharmacist-led management of chronic pain in primary care: results from a randomised controlled exploratory trial

Bruhn, H., Bond, C. M., Elliott, A. M., Hannaford, P. C., Lee, A. J., McNamee, P., Smith, B. H., Watson, M. C., Holland, R. & Wright, D. 5-Apr-2013 In : BMJ Open. 3, 4, e002361

Research output: Contribution to journal › Article

p53 Protein Isoforms: Key Regulators in the Front Line of Pathogen Infections?

Terrier, O., Bourdon, J-C. & Rosa-Calatrava, M. 4-Apr-2013 In : PLoS Pathogens. 9, 4, p. e1003246

Research output: Contribution to journal › Article

AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to K channels

Beall, C., Watterson, K. R., McCrimmon, R. J. & Ashford, M. L. J. Apr-2013 In : Journal of Bioenergetics and Biomembranes. p. 1-13, 13 p.

Research output: Contribution to journal › Article

Association Between BMI Measured Within a Year After Diagnosis of Type 2 Diabetes and Mortality

Logue, J., Walker, J. J., Leese, G., Lindsay, R., McKnight, J., Morris, A., Philip, S., Wild, S., Sattar, N. & Scottish Diabetes Research Network Epidemiology Group Apr-2013 In : Diabetes Care. 36, 4, p. 887-893, 7 p.

Research output: Contribution to journal › Article

Cost-effectiveness of self-management methods for the treatment of chronic pain in an aging adult population: a systematic review of the literature

Boyers, D., McNamee, P., Clarke, A., Jones, D., Martin, D., Schofield, P. & Smith, B. H. Apr-2013 In : Clinical Journal of Pain. 29, 4, p. 366-375, 10 p.

Research output: Contribution to journal › Article

Cross-border flow of health information: Is 'privacy by design' enough? Privacy performance assessment in EUBIROD

Di Iorio, C. T. , Carinci, F. , Brillante, M. , Cunningham, S. G. , Azzopardi, J. , Beck, P. , Bratina, N. , De Beaufort, C. , Debacker, N. , Jarosz-Chobot, P. , Jecht, M. , Lindblad, U. , Moulton, T. , Metelko, Ž. , Nagy, A. , Olympios, G. , Pruna, S. , Røder, M. , Skeie, S. , Storms, F. & 1 others Massi Benedetti, M. Apr-2013 In : European Journal of Public Health. 23, 2, p. 247-253, 7 p.

Research output: Contribution to journal › Article

Cutaneous distribution after brachial plexus blockade

Raju, P. K. B. C. & Coventry, D. M. Apr-2013 In : Anaesthesia. 68, 4, p. 442-442, 1 p.

Research output: Contribution to journal › Meeting abstract

Palliative care for patients with gastrointestinal cancer dying under surgical care: a case for acute palliative care units?

Young, J. A., Waugh, L., McPhillips, G., Levack, P. & Thompson, A. M. Apr-2013 In : Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland. 11, 2, p. 72-75, 4 p.

Research output: Contribution to journal › Article

Recessive mutations in the gene encoding frizzled 6 cause twenty nail dystrophy: Expanding the differential diagnosis for pachyonychia congenita

Wilson, N. J., Hansen, C. D., Azkur, D., Kocabas, C. N., Metin, A., Coskun, Z., Schwartz, M. E., Hull, P. R., McLean, W. H. I. & Smith, F. J. D. Apr-2013 In : Journal of Dermatological Science. 70, 1, p. 58-60, 3 p.

Research output: Contribution to journal › Letter

Reliability and validity of genotyping filaggrin null mutations

Margolis, D. J., Apter, A. J., Mitra, N., Gupta, J., Hoffstad, O., Papadopoulos, M., Rebbeck, T. R., MacCallum, S., Campbell, L. E., Sandilands, A. & McLean, W. H. I. Apr-2013 In : Journal of Dermatological Science. 70, 1, p. 67-68, 2 p.

Research output: Contribution to journal › Letter

Tailored second-line therapy in asthmatic children with the Arg16 genotype

Lipworth, B. J., Basu, K., Donald, H. P., Tavendale, R., MacGregor, D. F., Ogston, S. A., Palmer, C. N. A. & Mukhopadhyay, S. Apr-2013 In : Clinical Science. 124, 8, p. 521-528, 8 p.

Research output: Contribution to journal › Article

Targeting the small airways asthma phenotype: if we can reach it, should we treat it?

Lipworth, B. Apr-2013 In : Annals of Allergy, Asthma & Immunology. 110, 4, p. 233-239, 7 p.

Research output: Contribution to journal › Article

The clinical significance of calcium-signalling pathways mediating human sperm hyperactivation

Alasmari, W., Barratt, C. L. R., Publicover, S. J., Whalley, K. M., Foster, E., Kay, V., Martins Da Silva, S. & Oxenham, S. K. Apr-2013 In : Human Reproduction. 28, 4, p. 866-876, 11 p.

Research output: Contribution to journal › Article

Trimethoprim prescription and subsequent resistance in childhood urinary infection: multilevel modelling analysis

Duffy, M. A., Hernandez-Santiago, V., Orange, G., Davey, P. G. & Guthrie, B. Apr-2013 In : British Journal of General Practice. 63, 609, p. 238-43, 6 p.

Research output: Contribution to journal › Article

What should it take to describe a substance or product as 'sperm-safe'

Mortimer, D., Barratt, C. L. R., Björndahl, L., de Jager, C., Jequier, A. M. & Muller, C. H. Apr-2013 In : Human Reproduction Update. 19, SUPPL1, p. i1-i45, 45 p.

Research output: Contribution to journal › Article

Workplace dietary improvement initiatives ought not to be discouraged by modest returns from low-intensity interventions

Mooney, J. D., Frank, J. & Anderson, A. S. Apr-2013 In : European Journal of Public Health. 23, 2, p. 193-194, 2 p.

Research output: Contribution to journal › Article

Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells

Baird, L. & Dinkova-Kostova, A. T. 29-Mar-2013 In : Biochemical and Biophysical Research Communications. 433, 1, p. 58-65, 8 p.

Research output: Contribution to journal › Article

Cholinergic pesticides cause mushroom body neuronal inactivation in honeybees

Palmer, M. J., Moffat, C., Saranzewa, N., Harvey, J., Wright, G. A. & Connolly, C. N. 27-Mar-2013 In : Nature Communications. 4, 1634

Research output: Contribution to journal › Article

Dexterous manipulation of microparticles using Bessel-function acoustic pressure fields

Courtney, C. R. P., Drinkwater, B. W., Demore, C. E. M., Cochran, S., Grinenko, A. & Wilcox, P. D. 25-Mar-2013 In : Applied Physics Letters. 102, 12

Research output: Contribution to journal › Article

Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b beta2-integrin-dependent signalling

McMillan, S. J., Sharma, R. S., McKenzie, E. J., Richards, H. E., Zhang, J., Prescott, A. & Crocker, P. R. 14-Mar-2013 In : Blood. 121, 11, p. 2084-2094, 11 p.

Research output: Contribution to journal › Article

Obesity and lifestyle advice in colorectal cancer survivors - How well are clinicians prepared?

Anderson, A. S., Caswell, S., Wells, M. & Steele, R. J. C. 9-Mar-2013 In : Colorectal Disease. 15 p.

Research output: Contribution to journal › Article

Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression

Sachweh, M. C. C., Drummond, C. J., Higgins, M., Campbell, J. & Lain, S. 7-Mar-2013 In : Cell Death and Disease. 4, e533

Research output: Contribution to journal › Article

High-Dose Allopurinol reduces left ventricular mass in patients with ischemic heart disease

Rekhraj, S., Gandy, S. J., Szwejkowski, B. R., Nadir, M. A., Noman, A., Houston, G., Lang, C. C., George, J. & Struthers, A. D. 5-Mar-2013 In : Journal of the American College of Cardiology. 61, 9, p. 926-32, 7 p.

Research output: Contribution to journal › Article

Adrenal suppression with fluticasone furoate

Lipworth, B. J. Mar-2013 In : Annals of Allergy, Asthma & Immunology. 110, 3, p. 213

Research output: Contribution to journal › Letter

An inventory of European data sources for the long-term safety evaluation of methylphenidate

Murray, M. L., Insuk, S., Banaschewski, T., Neubert, A. C., McCarthy, S., Buitelaar, J. K., Coghill, D., Dittmann, R. W., Konrad, K., Panei, P., Rosenthal, E., Sonuga-Barke, E. J. & Wong, I. C. K. Mar-2013 In : European Child & Adolescent Psychiatry.

Research output: Contribution to journal › Article

Beta-secretase 1 (BACE1) inhibition improves obese and diabetic phenotypes in a leptin dependent manner

Meakin, P. J., Jalicy, S. M., Irvine, S. W. & Ashford, M. L. J. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. 41-41, 1 p., P43

Research output: Contribution to journal › Meeting abstract

Bifurcation of ensemble oscillations and acoustic emissions from early stage cavitation clouds in focused ultrasound

Gerold, B., Rachmilevitch, I. & Prentice, P. Mar-2013 In : New Journal of Physics. 15

Research output: Contribution to journal › Article

Clinical predictors of rate of progression of type 2 diabetes: an extreme case-control study

Donnelly, L. A., Zhou, K., Palmer, C. N. A., Doney, A. S. F., Morris, A. D. & Pearson, E. R. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. 94-94, 1 p., P213

Research output: Contribution to journal › Meeting abstract

Diabetes and schizophrenia: exploring the associations: determining the extent of diabetes and the quality of diabetes care within a clozapine (schizophrenia) clinic in Edinburgh

Perera, S. M., Cochrane, L., Wang, Y., MacIntyre, D. J. & Wake, D. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. 180-181, 2 p., P506

Research output: Contribution to journal › Meeting abstract

Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region

Smith, B. H. & 51 others Peters, M. J., Broer, L., Willemen, H. L. D. M., Eiriksdottir, G., Hocking, L. J., Holliday, K. L., Horan, M. A., Meulenbelt, I., Neogi, T., Popham, M., Schmidt, C. O., Soni, A., Valdes, A. M., Amin, N., Dennison, E. M., Eijkelkamp, N., Harris, T. B., Hart, D. J., Hofman, A., Huygen, F. J. P. M., Jameson, K. A., Jones, G. T., Launer, L. J., Kerkhof, H. J. M., De Kruijf, M., McBeth, J., Kloppenburg, M., Ollier, W. E., Oostra, B., Payton, A., Rivadeneira, F., Smith, A. V., Stolk, L., Teumer, A., Thomson, W., Uitterlinden, A. G., Wang, K., Van Wingerden, S. H., Arden, N. K., Cooper, C., Felson, D., Gudnason, V., Macfarlane, G. J., Pendleton, N., Slagboom, P. E., Spector, T. D., Völzke, H., Kavelaars, A., Van Duijn, C. M., Williams, F. M. K. & Van Meurs, J. B. J. Mar-2013 In : Annals of the Rheumatic Diseases. 72, 3, p. 427-436, 10 p.

Research output: Contribution to journal › Article

Getting to the heart of inpatient diabetes care

Jordan, L. V. M., Voigt, D. J. & Brennan, G. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. 151-151, 1 p., P410

Research output: Contribution to journal › Meeting abstract

Hormonal regulation of the Salt-inducible Kinase (SIK), a key mediator that controls hepatic gluconeogenesis

Patel, K., Goransson, O., Sutherland, C. & Sakamoto, K. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. E2-E2, 1 p., P577

Research output: Contribution to journal › Meeting abstract

How does glucophage (metformin) work? Investigation of the cellular action of chemical analogues

Logie, L., Bacon, S., Middleton, P., Harthill, J., Coats, J., Stewart, D., Sakamoto, K., McDougall, G. & Rena, G. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. 41-41, 1 p., P44

Research output: Contribution to journal › Meeting abstract

Influence of β2-adrenergic receptor polymorphism on methacholine hyperresponsiveness in asthmatic patients

Manoharan, A., Anderson, W. J. & Lipworth, B. J. Mar-2013 In : Annals of Allergy, Asthma & Immunology. 110, 3, p. 161-164, 4 p.

Research output: Contribution to journal › Article

Is thiazolidinedione treatment an important cause of oedema?

Vella, S., Donnelly, L., Lang, C. C., Pearson, E. R. & Petrie, J. R. Mar-2013 In : Diabetic Medicine. 30, Suppl. 1, p. 197-197, 1 p., P562

Research output: Contribution to journal › Meeting abstract