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  1. Reliability and validity of genotyping filaggrin null mutations

    Margolis, D. J., Apter, A. J., Mitra, N., Gupta, J., Hoffstad, O., Papadopoulos, M., Rebbeck, T. R., MacCallum, S., Campbell, L. E., Sandilands, A. & McLean, W. H. I. Apr-2013 In : Journal of Dermatological Science. 70, 1, p. 67-68, 2 p.

    Research output: Contribution to journal › Letter

  2. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

    MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S. & Tauro, S. 1-Jan-2013 In : Scientific Reports. 3, 1275

    Research output: Contribution to journal › Article

  3. Allele-specific siRNA silencing for the common keratin 12 founder mutation in Meesmann epithelial corneal dystrophy

    Allen, E. H. A., Atkinson, S. D., Liao, H., Moore, J. E., Pedrioli, D. M. L., Smith, F. J. D., McLean, W. H. I. & Moore, C. B. T. 2013 In : Investigative Ophthalmology & Visual Science. 54, 1, p. 494-502, 9 p.

    Research output: Contribution to journal › Article

  4. Detecting and quantifying p53 isoforms at mRNA level in cell lines and tissues

    Khoury, M. P., Marcel, V., Fernandes, K., Diot, A., Lane, D. P. & Bourdon, J-C. 2013 p53 protocols. Deb, S. & Deb, S. P. (eds.). Totowa, N.J.: Humana Press, Vol. 962, p. 1-14 14 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

  5. Detecting p53 isoforms at protein level

    Marcel, V., Khoury, M. P., Fernandes, K., Diot, A., Lane, D. P. & Bourdon, J-C. 2013 p53 protocols. Deb, S. & Deb, S. P. (eds.). Totowa, N.J.: Humana Press, Vol. 962, p. 15-29 15 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

  6. Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma

    Pohler, E. , Mamai, O. , Hirst, J. , Zamiri, M. , Horn, H. , Nomura, T. , Irvine, A. D. , Moran, B. , Wilson, N. J. , Smith, F. J. D. , Goh, C. S. M. , Sandilands, A. , Cole, C. , Barton, G. J. , Evans, A. T. , Shimizu, H. , Akiyama, M. , Suehiro, M. , Konohana, I. , Shboul, M. & 12 others Teissier, S., Boussofara, L., Denguezli, M., Saad, A., Gribaa, M., Dopping-Hepenstal, P. J., McGrath, J. A., Brown, S. J., Goudie, D. R., Reversade, B., Munro, C. S. & McLean, W. H. I. Nov-2012 In : Nature Genetics. 44, 11, p. 1272-1276, 5 p.

    Research output: Contribution to journal › Article

  7. Haploinsufficiency for alpha- and gamma-adaptin binding protein (AAGAB) p34 causes clinically heterogeneous forms of punctate palmoplantar keratoderma

    Pohler, E., Mamai, O., Hirst, J., Zamiri, M., Horn, H., Irvine, A. D., Nomura, T., McGrath, J. A., Munro, C. A. & McLean, W. Sep-2012 In : Journal of Investigative Dermatology. 132, p. S89-S89, 1 p.

    Research output: Contribution to journal › Meeting abstract

  8. Influenza A viruses control expression of proviral human p53 isoforms p53β and Delta133p53α

    Terrier, O., Marcel, V., Cartet, G., Lane, D. P., Lina, B., Rosa-Calatrava, M. & Bourdon, J-C. Aug-2012 In : Journal of Virology. 86, 16, p. 8452-8460, 9 p.

    Research output: Contribution to journal › Article

  9. Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant

    Palmer, C. N. A. , Burch, L. , Donnelly, L. A. , Colhoun, H. , Doney, A. S. , Dillon, J. F. , Pearson, E. R. , Morris, A. D. , Maglio, C. , Pirazzi, C. , Burza, M. A. , Adiels, M. , Svensson, P-A. , Jacobson, P. , Borén, J. , Sjöström, L. , Carlsson, L. M. S. , Romeo, S. , McCarthy, M. , Hattersley, A. T. & 2 others Frayling, T. & Peltonen, M. 18-Jun-2012 In : PLoS ONE. 7, 6, e39362

    Research output: Contribution to journal › Article

  10. Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin

    Sandilands, A., Brown, S. J., Goh, C. S., Pohler, E., Wilson, N. J., Campbell, L. E., Miyamoto, K., Kubo, A., Irvine, A. D., Thawer-Esmail, F., Munro, C. S., McLean, W. H. I., Kudoh, J., Amagai, M. & Matsui, T. May-2012 In : Journal of Investigative Dermatology. 132, 5, p. 1507-1510, 4 p.

    Research output: Contribution to journal › Letter

  11. The p53 isoforms are differentially modified by Mdm2

    Camus, S., Menendez, S., Fernandes, K., Kua, N., Liu, G., Xirodimas, D. P., Lane, D. P. & Bourdon, J-C. 15-Apr-2012 In : Cell Cycle. 11, 8, p. 1646-1655, 10 p.

    Research output: Contribution to journal › Article

  12. Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect

    Brown, S. J., Kroboth, K., Sandilands, A., Campbell, L. E., Pohler, E., Kezic, S., Cordell, H. J., McLean, W. H. I. & Irvine, A. D. Jan-2012 In : Journal of Investigative Dermatology. 132, 1, p. 98-104, 7 p.

    Research output: Contribution to journal › Article

  13. C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances

    Muller, P., Ruckova, E., Halada, P., Coates, P. J., Hrstka, R., Lane, D. P. & Vojtesek, B. 2012 In : Oncogene.

    Research output: Contribution to journal › Article

  14. Diverse p63 and p73 isoforms regulate Delta 133p53 expression through modulation of the internal TP53 promoter activity

    Marcel, V., Petit, I., Murray-Zmijewski, F., Goullet De Rugy, T., Fernandes, K., Meuray, V., Diot, A., Lane, D. P., Aberdam, D. & Bourdon, J-C. 2012 In : Cell Death & Differentiation. 19, 5, p. 816-826, 11 p.

    Research output: Contribution to journal › Article

  15. Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

    Ng, Y-Z., Pourreyron, C., Salas-Alanis, J. C., Dayal, J. H. S., Cepeda-Valdes, R., Yan, W., Wright, S., Chen, M., Fine, J-D., Hogg, F. J., McGrath, J. A., Murrell, D. F., Leigh, I. M., Lane, E. B. & South, A. P. 2012 In : Cancer Research. 72, 14, p. 3522-3534, 13 p.

    Research output: Contribution to journal › Article

  16. Heterogeneity of p53-pathway Protein Expression in Chemosensitive Chronic Lymphocytic Leukemia: A Pilot Study

    Groves, M. J., Maccallum, S. F., Boylan, M. T., Haydock, S., Cunningham, J., Gelly, K., Gowans, D., Kerr, R., Coates, P. J. & Tauro, S. 2012 In : International Journal of Cancer. 3, p. 354-361, 8 p.

    Research output: Contribution to journal › Article

  17. Scanning Ion Conductance Microscopy of Live Keratinocytes

    Hegde, V., Mason, A., Saliev, T., Smith, F., McLean, W. H. I. & Campbell, P. A. 2012 Electron Microscopy and Analysis Group Conference 2011 (EMAG 2011). Bristol: Institute of Physics, p. - 4 p.

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  18. The mechanical behavior of mutant K14-R125P keratin bundles and networks in NEB-1 keratinocytes

    Beriault, D. R., Haddad, O., McCuaig, J. V., Robinson, Z. J., Russell, D., Lane, E. B. & Fudge, D. S. 2012 In : PLoS ONE. 7, 2, p. -, 10 p., e31320

    Research output: Contribution to journal › Article

  19. The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage

    Nicol, S. M., Bray, S. E., Derek Black, H., Lorimore, S. A., Wright, E. G., Lane, D. P., Meek, D. W., Coates, P. J. & Fuller-Pace, F. V. 2012 In : Oncogene.

    Research output: Contribution to journal › Article

  20. Primary cutaneous CD8-positive T-cell Lymphoma: a case report of a rare and aggressive disease with oral presentation

    Geddes, A., Savin, J., White, S. & Gibson, J. Sep-2011 In : Dental Update. 38, 7, p. 472-4, 476, 4 p.

    Research output: Contribution to journal › Article

  21. Keratin 14-Null Cells as a Model to Test the Efficacy of Gene Therapy Approaches in Epithelial Cells

    D'Alessandro, M., Coats, S. E., Jonkmann, M. F., Leigh, I. M. & Lane, B. Jul-2011 In : Journal of Investigative Dermatology. 131, 7, p. 1412-1419, 8 p.

    Research output: Contribution to journal › Article

  22. Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations

    Chen, H., Common, J. E. A., Haines, R. L., Balakrishnan, A., Brown, S. J., Goh, C. S. M., Cordell, H. J., Sandilands, A., Campbell, L. E., Kroboth, K., Irvine, A. D., Goh, D. L. M., Tang, M. B. Y., van Bever, H. P., Giam, Y. C., McLean, W. H. I. & Lane, E. B. Jul-2011 In : British Journal of Dermatology. 165, 1, p. 106-114, 9 p.

    Research output: Contribution to journal › Article

  23. Filaggrin null mutations are not a protective factor for acne vulgaris

    Common, J. E. A., Brown, S. J., Haines, R. L., Goh, C. S. M., Chen, H., Balakrishnan, A., Munro, C. S., Tan, A. W. H., Tan, H. H., Tang, M. B. Y. & Lane, E. B. Jun-2011 In : Journal of Investigative Dermatology. 131, 6, p. 1378-1380, 3 p.

    Research output: Contribution to journal › Letter

  24. Statins downregulate K6a promoter activity: a possible therapeutic avenue for pachyonychia congenita

    Zhao, Y., Gartner, U., Smith, F. J. D. & McLean, W. H. I. May-2011 In : Journal of Investigative Dermatology. 131, 5, p. 1045-1052, 8 p.

    Research output: Contribution to journal › Article

  25. Copy number variation within the filaggrin gene contributes to risk of atopic dermatitis

    Brown, S. J., Kroboth, K., Sandilands, A., Campbell, L. E., Pohler, E., Irvine, A. D., Cordell, H. J. & McLean, W. Apr-2011 In : Journal of Investigative Dermatology. 131, Supplement 1, p. S63-S63, 1 p., 375

    Research output: Contribution to journal › Book/Film/Article review

  26. Developing small molecule drugs to rescue nonsense mutations in disease-causing genes

    Nomura, T., Gartner, U., McElroy, S., Torrie, L., Pourreyron, C., South, A. P., Wood, G., Woodland, A., Frearson, J., Wyatt, P. & McLean, I. Apr-2011 In : Journal of Investigative Dermatology. 131, p. S67-S67, 1 p., 397

    Research output: Contribution to journal › Book/Film/Article review

  27. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

    Sutherland, C. & 50 others Zhou, K., Bellenguez, C., Spencer, C. C. A., Bennett, A. J., Coleman, R. L., Tavendale, R., Hawley, S. A., Donnelly, L. A., Schofield, C., Groves, C. J., Burch, L., Carr, F., Strange, A., Freeman, C., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Craddock, N., Deloukas, P., Dronov, S., Duncanson, A., Edkins, S., Gray, E., Hunt, S., Jankowski, J., Langford, C., Markus, H. S., Mathew, C. G., Plomin, R., Rautanen, A., Sawcer, S. J., Samani, N. J., Trembath, R., Viswanathan, A. C., Wood, N. W., Harries, L. W., Hattersley, A. T., Doney, A. S. F., Colhoun, H., Morris, A. D., Hardie, D. G., Peltonen, L., McCarthy, M. I., Holman, R. R., Palmer, C. N. A., Donnelly, P., Pearson, E. R. & Wellcome Trust Case Control Consor, GoDARTS UKPDS Diabet Pharmacogenet, MAGIC Investigators Feb-2011 In : Nature Genetics. 43, 2, p. 117-U57, 6 p.

    Research output: Contribution to journal › Article

  28. p53 directly transactivates Delta 133p53 alpha, regulating cell fate outcome in response to DNA damage

    Aoubala, M., Murray-Zmijewski, F., Khoury, M. P., Fernandes, K., Perrier, S., Bernard, H., Prats, A-C., Lane, D. P. & Bourdon, J-C. Feb-2011 In : Cell Death & Differentiation. 18, 2, p. 248-258, 11 p.

    Research output: Contribution to journal › Article

  29. Cyp2c8 variant reduce the therapeutic response to thiazolidinediones - a godarts study

    Zhou, K., Burch, L., Vella, S., Palmer, C. N. A. & Pearson, E. R. Sep-2010 In : Diabetologia. 53, p. S133-S133, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  30. Tumour microenvironment is implicated by dermal fibroblast expression profiling in the development of aggressive squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

    Ng, Y. Z., Pourreyron, C., Salas-Alanis, J. C., Murrell, D. F., McGrath, J. A., Lane, E. B., Leigh, I. & South, A. Sep-2010 In : Journal of Investigative Dermatology. 130, p. S83-S83, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  31. Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults

    Mukhopadhyay, S., Sypek, J., Tavendale, R., Gartner, U., Winter, J., Li, W., Page, K., Fleming, M., Brady, J., O'Toole, M., Macgregor, D. F., Goldman, S., Tam, S., Abraham, W., Williams, C., Miller, D. K. & Palmer, C. N. A. Jul-2010 In : Journal of Allergy and Clinical Immunology. 126, 1, p. 70-76, 7 p.

    Research output: Contribution to journal › Article

  32. Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors

    Wang, S. , Midgley, C. A. , Scaërou, F. , Grabarek, J. B. , Griffiths, G. , Jackson, W. , Kontopidis, G. , McClue, S. J. , McInnes, C. , Meades, C. , Mezna, M. , Plater, A. , Stuart, I. , Thomas, M. P. , Wood, G. , Clarke, R. G. , Blake, D. G. , Zheleva, D. I. , Lane, D. P. , Jackson, R. C. & 2 others Glover, D. M. & Fischer, P. M. 10-Jun-2010 In : Journal of Medicinal Chemistry. 53, 11, p. 4367-4378, 12 p.

    Research output: Contribution to journal › Article

  33. PPARG, insulin resistance and metformin pharmacogenetics-A GoDARTS study

    Zhou, K., Burch, L., Hattersley, A. T., McCarthy, M. I., Morris, A. D., Palmer, C. N. A. & Pearson, E. R. Jun-2010 In : Diabetes. 59, p. A115-A115, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  34. Additional genes involved in epidermolysis bullosa simplex

    Pohler, E., Terron-Kwiatkowski, A., Baty, D. U., Mellerio, J. E. & McLean, W. H. I. Apr-2010 In : British Journal of Dermatology. 162, 4, p. 939-940, 2 p., P34

    Research output: Contribution to journal › Book/Film/Article review

  35. Dermal fibroblast expression profiling implicates tumour microenvironment in the development of aggressive squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

    Ng, Y. Z., Pourreyron, C., Proby, C., Salas, J., Murrell, D. F., McGrath, J. A., Lane, E. B., Leigh, I. M. & South, A. P. Apr-2010 In : British Journal of Dermatology. 162, 4, p. 948-948, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  36. Immunohistochemical localization of cellular NFATc1 does not predict clinical responses to ciclosporin in subcutaneous panniculitis-like T-cell non-Hodgkin lymphoma

    Tauro, S., MacCallum, S., Groves, M. J., Rojnuckarin, P., Assanasen, T., Feldman, A. L., Robson, A., Marschalko, M., Kini, H., Alzolibani, A. A., Al Robaee, A., Al Shobaili, H. A., Alfawzan, S., Goodlad, J. R., Kernohan, N., Hummel, M., Sterry, W. & Assaf, C. Apr-2010 In : British Journal of Dermatology. 162, 4, p. 887-889, 3 p.

    Research output: Contribution to journal › Letter

  37. Peroxisome proliferator-activated receptor-delta genotype influences metabolic phenotype and may Influence lipid response to statin therapy in humans: A genetics of diabetes audit and research Tayside study

    Burch, L. R., Donnelly, L. A., Doney, A. S. F., Brady, J., Tommasi, A. M., Whitley, A. L., Goddard, C., Morris, A. D., Hansen, M. K. & Palmer, C. N. A. Apr-2010 In : Journal of Clinical Endocrinology & Metabolism. 95, 4, p. 1830-1837, 8 p.

    Research output: Contribution to journal › Article

  38. Keratin K6c mutations cause focal palmoplantar keratoderma

    Wilson, N. J., Messenger, A. G., Leachman, S. A., O'Toole, E. A., Lane, E. B., McLean, W. H. I. & Smith, F. J. D. Feb-2010 In : Journal of Investigative Dermatology. 130, 2, p. 425-429, 5 p.

    Research output: Contribution to journal › Article

  39. MdmX is a substrate for the deubiquitinating enzyme USP2a

    Allende-Vega, N., Sparks, A., Lane, D. P. & Saville, M. K. 21-Jan-2010 In : Oncogene. 29, 3, p. 432-441, 10 p.

    Research output: Contribution to journal › Article

  40. Loss-of-function CYP2C9 variants improve therapeutic response to sulfonylureas in type 2 diabetes: A Go-DARTS study

    Zhou, K., Donnelly, L., Burch, L., Tavendale, R., Doney, A. S. F., Leese, G., Hattersley, A. T., McCarthy, M. I., Morris, A. D., Lang, C. C., Palmer, C. N. A. & Pearson, E. R. Jan-2010 In : Clinical Pharmacology & Therapeutics. 87, 1, p. 52-56, 5 p.

    Research output: Contribution to journal › Article

  41. Late simultaneous metastasis of renal cell carcinoma to the submandibular and thyroid glands seven years after radical nephrectomy

    Miah, M., White, S., Oommen, G., Birney, E. & Majumdar, S. 2010 In : International Journal of Otolaryngology. 4 p., 698014

    Research output: Contribution to journal › Article

  42. Steatocystoma multiplex, oligodontia and partial persistent primary dentition associated with a novel keratin 17 mutation

    Gass, J. K., Wilson, N. J., Smith, F. J. D., Lane, E. B., McLean, W. H. I. M., Rytina, E., Salvary, I. & Burrows, N. P. Dec-2009 In : British Journal of Dermatology. 161, 6, p. 1396-1398, 3 p.

    Research output: Contribution to journal › Article

  43. A single nucleotide polymorphism on Exon-4 of the gene encoding PPAR delta is associated with reduced height inadults and children

    Burch, L. R., Zhou, K., Donnelly, L. A., Doney, A. S. F., Brady, J., Goddard, C., Morris, A. D., Hansen, M. K. & Palmer, C. N. A. Jul-2009 In : Journal of Clinical Endocrinology & Metabolism. 94, 7, p. 2587-2593, 7 p.

    Research output: Contribution to journal › Article

  44. Autoimmune pancytopenia following combination chemotherapy for chronic lymphocytic leukaemia

    MacCallum, S., Groves, M., Brass, D., Cunningham, J., Sales, M., Gelly, K. & Tauro, S. May-2009 In : Journal of Clinical Pathology. 62, 5, p. 468-470, 3 p.

    Research output: Contribution to journal › Article

  45. The annexin-V assay reflects susceptibility to in vitro membrane damage in chronic lymphocytic leukemia and may overestimate cell death

    Groves, M. J., MacCallum, S., Boylan, M. T., Coates, P. J. & Tauro, S. Mar-2009 In : American Journal of Hematology. 84, 3, p. 196-197, 2 p.

    Research output: Contribution to journal › Letter

  46. Suppression of the Deubiquitinating Enzyme USP5 Causes the Accumulation of Unanchored Polyubiquitin and the Activation of p53

    Dayal, S., Sparks, A., Jacob, J., Allende-Vega, N., Lane, D. & Saville, M. K. 20-Feb-2009 In : Journal of Biological Chemistry. 284, 8, p. 5030-5041, 12 p.

    Research output: Contribution to journal › Article

  47. Characterization, chemical optimization and anti-tumour activity of a tubulin poison identified by a p53-based phenotypic screen

    Staples, O. D., Hollick, J. J., Campbell, J., Higgins, M., McCarthy, A. R., Appleyard, V., Murray, K. E., Baker, L., Thompson, A., Ronseaux, S., Slawin, A. M. Z., Lane, D. P., Westwood, N. J. & Lain, S. 1-Nov-2008 In : Cell Cycle. 7, 21, p. 3417-3427, 11 p.

    Research output: Contribution to journal › Article

  48. Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita

    Leachman, S. A., Hickerson, R. P., Hull, P. R., Smith, F. J. D., Milstone, L. M., Lane, E. B., Bale, S. J., Roop, D. R., McLean, W. H. I. & Kaspar, R. L. Sep-2008 In : Journal of Dermatological Science. 51, 3, p. 151-157, 7 p.

    Research output: Contribution to journal › Scientific review

  49. Steatocystoma multiplex and persistent primary dentition due to a novel keratin 17 mutation

    Gass, J. K., Wilson, N. J., Smith, E. B. F., Lane, B., McLean, W. H. I., Salvary, I. & Burrows, N. P. Jul-2008 In : British Journal of Dermatology. 159, p. 119-119, 1 p., PA-13

    Research output: Contribution to journal › Book/Film/Article review

  50. Discovery, in vivo activity and mechanism of action of a small-molecule p53 activator

    Lain, S., Hollick, J. J., Campbell, J., Staples, O. D., Higgins, M., Aoubala, M., McCarthy, A., Appleyard, V., Murray, K. E., Baker, L., Thompson, A., Mathers, J., Holland, S. J., Stark, M. J. R., Pass, G., Woods, J., Lane, D. P. & Westwood, N. J. 6-May-2008 In : Cancer Cell. 13, 5, p. 454-463, 10 p.

    Research output: Contribution to journal › Article

  51. Keratin K6c mutations cause focal keratoderma

    Wilson, N. J., Messenger, A. G., Leachmin, S. A., Lane, E. B., McLean, W. & Smith, F. J. Apr-2008 In : Journal of Investigative Dermatology. 128, p. S127-S127, 1 p., Abstract 757

    Research output: Contribution to journal › Book/Film/Article review

  52. p53 activating benzoyl urea and benzoyl thiourea compounds

    Lain, S., Lane, D., Stark, M. J. R., McCarthy, A. R., Hollick, J. J. & Westwood, N. J. 13-Mar-2008 WO2008029096

    Research output: Patent

  53. Broken bricks and cracked mortar - epidermal diseases resulting from genetic abnormalities

    Lane, E. B. & McLean, W. H. I. 1-Mar-2008 In : Drug Discovery Today: Disease Mechanisms. 5, 1

    Research output: Contribution to journal › Article

  54. The human intermediate filament database: Comprehensive information on a gene family involved in many human diseases

    Szeverenyi, I. , Cassidy, A. J. , Chung, C. W. , Lee, B. T. , Common, J. E. A. , Ogg, S. C. , Chen, H. , Sim, S. Y. , Goh, W. L. R. , Ng, K. W. , Simpson, J. A. , Chee, L. L. , Eng, G. H. , Li, B. , Lunny, D. P. , Chuon, D. , Venkatesh, A. , Khoo, K. H. , McLean, W. H. I. , Lim, Y. P. & 1 others Lane, E. B. Mar-2008 In : Human Mutation. 29, 3, p. 351-360, 10 p.

    Research output: Contribution to journal › Article

  55. Toward an improved prediction of human in vivo brain penetration

    Summerfield, S. G., Lucas, A. J., Porter, R. A., Jeffrey, P., Gunn, R. N., Read, K. R., Stevens, A. J., Metcalf, A. C., Osuna-Cabello, M. C., Kilford, P. J., Passchier, J. & Ruffo, A. D. 2008 In : Xenobiotica. 38, 12, p. 1518-1535, 18 p.

    Research output: Contribution to journal › Article

  56. Novel Mdm2 intron 1 single nucleotide polymorphisms and their role in breast cancer

    Paulin, F., O'Neill, M., McGregor, G., Cassidy, A., Ashfield, A., Ali, C. W., Baker, L., Munro, A. J., Lane, D. & Thompson, A. M. Dec-2007 In : Breast Cancer Research and Treatment. 106, p. S285-S285, 1 p., 6114

    Research output: Contribution to journal › Book/Film/Article review

  57. The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

    Stevenson, L. F., Sparks, A., Allende-Vega, N., Xirodimas, D. P., Lane, D. & Saville, M. K. 2007 In : The EMBO Journal. 26, 4, p. 976-986, 11 p.

    Research output: Contribution to journal › Article

  58. Ubiquitin-independent degradation of p53 mediated by high-risk human papillomavirus protein E6

    Camus, S., Menendez, S., Cheok, C. F., Stevenson, L. F., Lain, S. & Lane, D. P. 2007 In : Oncogene. 26, 28, p. 4059-4070, 12 p.

    Research output: Contribution to journal › Article

  59. p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress

    Murray-Zmijewski, F., Lane, D. & Bourdon, J-C. Jun-2006 In : Cell Death & Differentiation. 13, 6, p. 962-972, 11 p.

    Research output: Contribution to journal › Scientific review

  60. Tumor susceptibility and apoptosis defect in a mouse strain expressing a human p53 transgene

    Dudgeon, C., Kek, C., Demidov, O. N., Saito, S., Fernandes, K., Diot, A., Bourdon, J-C., Lane, D. P., Appella, E., Fornace Jr., A. J. & Bulavin, D. V. 15-Mar-2006 In : Cancer Research. 66, 6, p. 2928-2936, 9 p.

    Research output: Contribution to journal › Article

  61. A functional analysis of PCNA-binding peptides derived from protein sequence, interaction screening and rational design

    Warbrick, E. 2006 In : Oncogene. 25, 20, p. 2850-2859, 10 p.

    Research output: Contribution to journal › Article

  62. The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury

    Darragh, J., Hunter, M., Pohler, E., Nelson, L., Dillon, J. F., Nenutil, R., Vojtesek, B., Ross, P. E., Kernohan, N. & Hupp, T. R. 2006 In : FEBS Journal. 273, 9, p. 1930-1947, 18 p.

    Research output: Contribution to journal › Article

  63. The p66 and p12 subunits of DNA polymerase δ are modified by ubiquitin and ubiquitin-like proteins

    Liu, G. & Warbrick, E. 2006 In : Biochemical and Biophysical Research Communications. 349, 1, p. 360-366, 7 p.

    Research output: Contribution to journal › Article

  64. Loss of function of def selectively up-regulates Δ113p53 expression to arrest expansion growth of digestive organs in zebrafish

    Chen, J., Ruan, H., Ng, S. M., Gao, C., Soo, H. M., Wu, W., Zhang, Z., Wen, Z., Lane, D. & Peng, J. Dec-2005 In : Genes & Development. 19, 23, p. 2900-2911, 12 p.

    Research output: Contribution to journal › Article

  65. p53 isoforms can regulate p53 transcriptional activity

    Bourdon, J. C., Fernandes, K., Murray-Zmijewski, F., Liu, G., Diot, A., Xirodimas, D. P., Saville, M. K. & Lane, D. P. 15-Sep-2005 In : Genes & Development. 19, 18, p. 2122-2137, 16 p.

    Research output: Contribution to journal › Article

  66. The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor

    Bates, G. J., Nicol, S. M., Wilson, B. J., Jacobs, A-M. F., Bourdon, J-C., Wardrop, J., Gregory, D. J., Lane, D. P., Perkins, N. D. & Fuller-Pace, F. V. 9-Feb-2005 In : The EMBO Journal. 24, 3, p. 543-553, 11 p.

    Research output: Contribution to journal › Article

  67. P53 abnormalities and outcomes in colorectal cancer: a systematic review

    Munro, A. J., Lain, S. & Lane, D. P. Feb-2005 In : British Journal of Cancer. 92, 3, p. 434-444, 11 p.

    Research output: Contribution to journal › Article

  68. An in vivo analysis of the localisation and interactions of human p66 DNA polymerase δ subunit

    Pohler, J. R. G., Otterlei, M. & Warbrick, E. 2005 In : BMC Molecular Biology. 6, 1, p. 17-30, 14 p.

    Research output: Contribution to journal › Article

  69. Pilot screening programme for small molecule activators of p53

    Berkson, R. G., Hollick, J. J., Westwood, N. J., Woods, J. A., Lane, D. P. & Lain, S. 2005 In : International Journal of Cancer. 115, 5, p. 701-710, 10 p.

    Research output: Contribution to journal › Article

  70. Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo

    Saville, M. K., Sparks, A., Xirodimas, D. P., Wardrop, J., Stevenson, L. F., Bourdon, J-C., Woods, Y. L. & Lane, D. P. 1-Oct-2004 In : Journal of Biological Chemistry. 279, 40, p. 42169-42181, 13 p.

    Research output: Contribution to journal › Article

  71. Mechanical stress induces profound remodelling of keratin filaments and cell junctions in epidermolysis bullosa simplex keratinocytes

    Russell, D., Andrews, P. D., James, J. & Lane, E. B. Oct-2004 In : Journal of Cell Science. 117, 22, p. 5233-5243, 11 p.

    Research output: Contribution to journal › Article

  72. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

    Xirodimas, D. P., Saville, M. K., Bourdon, J. C., Hay, R. T. & Lane, D. P. 9-Jul-2004 In : Cell. 118, 1, p. 83-97, 15 p.

    Research output: Contribution to journal › Article

  73. Human keratin 8 mutations that disturb filament assembly observed in inflammatory bowel disease patients

    Owens, D. W., Wilson, N. J., Hill, A. J. M., Rugg, E. L., Porter, R. M., Hutcheson, A. M., Quinlan, R. A., van Heel, D., Parkes, M., Jewell, D. P., Campbell, S. S., Ghosh, S., Satsangi, J. & Lane, E. B. Apr-2004 In : Journal of Cell Science. 117, 10, p. 1989-1999, 11 p.

    Research output: Contribution to journal › Article

  74. Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1

    Burch, L. R., Scott, M., Pohler, E., Meek, D. & Hupp, T. 12-Mar-2004 In : Journal of Molecular Biology. 337, 1, p. 115-128, 14 p.

    Research output: Contribution to journal › Article

  75. p14 arf promotes small ubiquitin-like modifier conjugation of Werners helicase

    Woods, Y. L., Xirodimas, D. P., Prescott, A. R., Sparks, A., Lane, D. P. & Saville, M. K. 2004 In : Journal of Biological Chemistry. 279, 48, p. 50157-50166, 10 p.

    Research output: Contribution to journal › Article

  76. SEP53 and AG-2 may act as proto-oncogenes in Barrett's metaplasia

    Dalziel, H. H., Pohler, E., Quayle, L., Cotton, J. P., Hupp, T. R. & Dillon, J. F. 2004 In : Gut. 53, S3, p. A35-A35

    Research output: Contribution to journal › Meeting abstract

  77. The Barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damage

    Pohler, E., Craig, A. L., Cotton, J., Lawrie, L., Dillon, J. F., Ross, P., Kernohan, N. & Hupp, T. R. 2004 In : Molecular & Cellular Proteomics. 3, 6, p. 534-547, 14 p.

    Research output: Contribution to journal › Article

  78. Oligomerization of the human ARF tumor suppressor and its response to oxidative stress

    Menendez, S., Khan, Z., Coomber, D., Lane, D., Higgins, M., Koufali, M. M. & Lain, S. May-2003 In : Journal of Biological Chemistry. 278, 21, p. 18720-18729, 10 p.

    Research output: Contribution to journal › Article

  79. Alteration of glutathione S-transferase levels in Barrett's metaplasia compared to normal oesophageal epithelium

    Cobbe, S. C., Scobie, G. C., Pohler, E., Hayes, J. D., Kernohan, N. M. & Dillon, J. F. 2003 In : European Journal of Gastroenterology & Hepatology. 15, 1, p. 41-47, 7 p.

    Research output: Contribution to journal › Article

  80. Dysregulation of the major squamous cell stress responsive system in Barrett's metaplasia

    Dalziel, H. H., Pohler, E., Craig, A. L., Kernohan, N., Hopwood, D., Dillon, J. F. & Hupp, T. R. 2003 In : Gut. 52, S1, p. A7-A7, 1 p.

    Research output: Contribution to journal › Meeting abstract

  81. Observation of keratin particles showing fast bidirectional movement colocalized with microtubules

    Liovic, M., Mogensen, M. M., Prescott, A. R. & Lane, E. B. 2003 In : Journal of Cell Science. 116, 8, p. 1417-1427, 11 p.

    Research output: Contribution to journal › Article

  82. p53: 25 years of research and more questions to answer

    Bourdon, J. C., De Laurenzi, V., Melino, G. & Lane, D. 2003 In : Cell Death & Differentiation. 10, 4, p. 397-399, 3 p.

    Research output: Contribution to journal › Editorial

  83. Preliminary assessment of p53 and related genes as therapies for oesophageal cancer

    Abouda, G. F., Pohler, E. & Dillon, J. F. 2003 In : Gut. 52, p. A57-A58, 1 p.

    Research output: Contribution to journal › Meeting abstract

  84. In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)

    McClue, S. J., Blake, D., Clarke, R., Cowan, A., Cummings, L., Fischer, P. M., MacKenzie, M., Melville, J., Stewart, K., Wang, S., Zhelev, N., Zheleva, D. & Lane, D. Dec-2002 In : International Journal of Cancer. 102, 5, p. 463-468, 6 p.

    Research output: Contribution to journal › Article

  85. Hypophosphorylation of Mdm2 augments p53 stability

    Blattner, C., Hay, T., Meek, D. W. & Lane, D. P. Sep-2002 In : Molecular and Cellular Biology. 22, 17, p. 6170-6182, 13 p.

    Research output: Contribution to journal › Article

  86. Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

    Bourdon, J-C., Renzing, J., Robertson, P. L., Fernandes, K. N. & Lane, D. P. 22-Jul-2002 In : Journal of Cell Biology. 158, 2, p. 235-246, 12 p.

    Research output: Contribution to journal › Article

  87. Cell type-specific responses of human cells to inhibition of replication licensing

    Shreeram, S., Sparks, A., Lane, D. P. & Blow, J. J. 2002 In : Oncogene. 21, 43, p. 6624-6632, 9 p.

    Research output: Contribution to journal › Article

  88. Keratin mutations of epidermolysis bullosa simplex alter the kinetics of stress response to osmotic shock

    D'Alessandro, M., Russell, D., Morley, S. M., Davies, A. M. & Lane, E. B. 2002 In : Journal of Cell Science. 115, 22, p. 4341-4351, 11 p.

    Research output: Contribution to journal › Article

  89. P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2

    Xirodimas, D. P., Chisholm, J., Desterro, J. M. S., Lane, D. P., Hay, R. T. & Celis, J. (ed.) 2002 In : FEBS Letters. 528, 1-3, p. 207-211, 5 p.

    Research output: Contribution to journal › Article

  90. Transfection into and expression of p53 in the human oesophagus: an ex vivo study

    Pohler, E., Ross, P. E. & Dillon, J. F. 2002 In : Gut. 50, S2, p. A123-A124, 2 p.

    Research output: Contribution to journal › Meeting abstract

  91. Biological significance of a small highly conserved region in the N terminus of the p53 tumour suppressor protein

    Liu, W-L., Midgley, C., Stephen, C., Saville, M. & Lane, D. Nov-2001 In : Journal of Molecular Biology. 313, 4, p. 711-731, 21 p.

    Research output: Contribution to journal › Article

  92. Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53

    Xirodimas, D., Stephen, C. W. & Lane, D. Oct-2001 In : Experimental Cell Research. 270, 1, p. 66-77, 12 p.

    Research output: Contribution to journal › Article

  93. Induction of endogenous β-galactosidase by ionizing radiation complicates the analysis of p53-LacZ transgenic mice

    Coates, P., Lorimore, S., Rigat, B. A., Lane, D. & Wright, E. Oct-2001 In : Oncogene. 20, 48, p. 7096-7097, 2 p.

    Research output: Contribution to journal › Article

  94. Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo

    Xirodimas, D., Saville, M. K., Edling, C., Lane, D. & Lain, S. 2001 In : Oncogene. 20, 36, p. 4972-4983, 12 p.

    Research output: Contribution to journal › Article

  95. Inhibition of cell proliferation by the PCNA-binding region of p21 expressed as a GFP miniprotein

    Mattock, H., Lane, D. & Warbrick, E. 2001 In : Experimental Cell Research. 265, 2, p. 234-241, 8 p.

    Research output: Contribution to journal › Article

  96. The application of magnetic resonance microimaging to the visible light curing of dental resins: 3. Stray-field nuclear magnetic resonance imaging (STRAFI)

    Lloyd, C. H., Scrimgeour, S. N., Lane, D. M., Hunter, G. & McDonald, P. J. 2001 In : Dental Materials. 17, 5, p. 381-387, 7 p.

    Research output: Contribution to journal › Article

  97. Fen1 expression: a novel marker for cell proliferation

    Warbrick, E., Coates, P. J. & Hall, P. A. 1998 In : Journal of Pathology. 186, 3, p. 319-324, 6 p.

    Research output: Contribution to journal › Article

  98. Distinct nuclear assembly pathways for lamins A and C lead to their increase during quiescence in Swiss 3T3 cells

    Pugh, G. E., Coates, P. J., Lane, E. B., Raymond, Y. & Quinlan, R. A. 1997 In : Journal of Cell Science. 110, 19, p. 2483-2493, 11 p.

    Research output: Contribution to journal › Article

  99. p53 - integrating the complexity

    Hall, P. A., Meek, D. & Lane, D. P. Sep-1996 In : Journal of Pathology. 180, 1, p. 1-5, 5 p.

    Research output: Contribution to journal › Editorial

  100. Plectin deficiency results in muscular dystrophy with epidermolysis bullosa

    Smith, F. J. D., Eady, R. A. J., Leigh, I. M., McMillan, J. R., Rugg, E. L., Kelsell, D. P., Bryant, S. P., Spurr, N. K., Geddes, J. F., Kirtschig, G., Milana, G., De Bono, A. G., Owaribe, K., Wiche, G., Pulkkinen, L., Uitto, J., McLean, W. H. I. & Lane, E. B. Aug-1996 In : Nature Genetics. 13, 4, p. 450-457, 8 p.

    Research output: Contribution to journal › Article

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