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  1. POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in Head and Neck cancer

    Sharpe, D. J., Orr, K. S., Moran, M., White, S. J., McQuaid, S., Lappin, T. R., Thompson, A. & James, J. A. 16 Sep 2014 In : Oncotarget. 5, 18, p. 8803-8815 13 p.

    Research output: Contribution to journalArticle

  2. New and recurrent AAGAB mutations in punctate palmoplantar keratoderma

    Pohler, E., Huber, M., Boonen, S. E., Zamiri, M., Gregersen, P. A., Sommerlund, M., Ramsing, M., Hohl, D., McLean, W. H. I. & Smith, F. J. Aug 2014 In : British Journal of Dermatology. 171, 2, p. 433-436

    Research output: Contribution to journalLetter

  3. Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung

    McMillan, S. J., Sharma, R. S., Richards, H. E., Hegde, V. & Crocker, P. R. 18 Jul 2014 In : Journal of Biological Chemistry. 289, 29, p. 20370-20376 7 p.

    Research output: Contribution to journalArticle

  4. The PAS domain-containing histidine kinase RpfS is a second sensor for the diffusible signal factor of Xanthomonas campestris

    An, S-Q., Allan, J. H., McCarthy, Y., Febrer, M., Dow, J. M. & Ryan, R. P. May 2014 In : Molecular Microbiology. 92, 3, p. 586-597 12 p.

    Research output: Contribution to journalArticle

  5. Peptide aptamers define distinct EB1- and EB3-binding motifs and interfere with microtubule dynamics

    Lesniewska, K., Warbrick, E. & Ohkura, H. 1 Apr 2014 In : Molecular Biology of the Cell. 25, 7, p. 1025-1036 12 p.

    Research output: Contribution to journalArticle

  6. Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants

    Flohr, C., Perkin, M., Logan, K., Marrs, T., Radulovic, S., Campbell, L. E., Maccallum, S. F., McLean, W. H. I. & Lack, G. Feb 2014 In : Journal of Investigative Dermatology. 134, 2, p. 345-350 6 p.

    Research output: Contribution to journalArticle

  7. How detection of epigenetic alterations of blood-borne DNA could improve melanoma diagnosis

    Hatzimichael, E., Syed, N., Lo Nigro, C., Rao, B. & Crook, T. 2014 In : Expert Review of Molecular Diagnostics. 14, 6, p. 639-642 4 p.

    Research output: Contribution to journalArticle

  8. Heterozygous mutations in AAGAB cause type 1 punctate palmoplantar keratoderma with evidence for increased growth factor signaling

    Pohler, E., Zamiri, M., Harkins, C., Salas-Alanis, J. C., Perkins, W., Smith, F. J. D., McLean, W. H. I. & Brown, S. J. Dec 2013 In : Journal of Investigative Dermatology. 133, 12, p. 2805-2808 4 p.

    Research output: Contribution to journalLetter

  9. A cyclic GMP-dependent signalling pathway regulates bacterial phytopathogenesis

    An, S-Q., Chin, K-H., Febrer, M., McCarthy, Y., Yang, J-G., Liu, C-L., Swarbreck, D., Rogers, J., Dow, J. M., Chou, S-H. & Ryan, R. P. 11 Sep 2013 In : EMBO Journal. 32, 18, p. 2430-2438

    Research output: Contribution to journalArticle

  10. The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage

    Nicol, S. M., Bray, S. E., Derek Black, H., Lorimore, S. A., Wright, E. G., Lane, D. P., Meek, D. W., Coates, P. J. & Fuller-Pace, F. V. 18 Jul 2013 In : Oncogene. 32, 29, p. 3461-3469 9 p.

    Research output: Contribution to journalArticle

  11. Early-onset eczema and disease severity are the main risk factors for food sensitization at 3 months of age in exclusively breastfed infants

    Greenblatt, D., Perkin, M., Logan, K., Marrs, T., Radulovic, S., Campbell, L. E., MacCallum, S. F., McLean, W. H. I., Lack, G. & Flohr, C. Jul 2013 In : British Journal of Dermatology. 169, Suppl. 1, p. 113 1 p.PA01

    Research output: Contribution to journalMeeting abstract

  12. High-resolution transcriptional analysis of the regulatory influence of cell-to-cell signalling reveals novel genes that contribute to Xanthomonas phytopathogenesis

    An, S-Q., Febrer, M., McCarthy, Y., Tang, D-J., Clissold, L., Kaithakottil, G., Swarbreck, D., Tang, J-L., Rogers, J., Dow, J. M. & Ryan, R. P. Jun 2013 In : Molecular Microbiology. 88, 6, p. 1058-1069 12 p.

    Research output: Contribution to journalArticle

  13. Generation and characterisation of keratin 7 (K7) knockout mice

    Sandilands, A., Smith, F. J. D., Lunny, D. P., Campbell, L. E., Davidson, K. M., MacCallum, S. F., Corden, L. D., Christie, L., Fleming, S., Lane, E. B. & McLean, W. H. I. 31 May 2013 In : PLoS ONE. 8, 5, 11 p.e64404

    Research output: Contribution to journalArticle

  14. Reliability and validity of genotyping filaggrin null mutations

    Margolis, D. J., Apter, A. J., Mitra, N., Gupta, J., Hoffstad, O., Papadopoulos, M., Rebbeck, T. R., MacCallum, S., Campbell, L. E., Sandilands, A. & McLean, W. H. I. Apr 2013 In : Journal of Dermatological Science. 70, 1, p. 67-68 2 p.

    Research output: Contribution to journalLetter

  15. A Lack of premature termination codon read-through efficacy of PTC124 (Ataluren) in a diverse array of reporter assays

    McElroy, S. P., Nomura, T., Torrie, L. S., Warbrick, E., Gartner, U., Wood, G. & McLean, W. H. I. 2013 In : PLoS Biology. 11, 6, e1001593

    Research output: Contribution to journalArticle

  16. Allele-specific siRNA silencing for the common keratin 12 founder mutation in Meesmann epithelial corneal dystrophy

    Allen, E. H. A., Atkinson, S. D., Liao, H., Moore, J. E., Pedrioli, D. M. L., Smith, F. J. D., McLean, W. H. I. & Moore, C. B. T. 2013 In : Investigative Ophthalmology & Visual Science. 54, 1, p. 494-502 9 p.

    Research output: Contribution to journalArticle

  17. Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting

    Samuelov, L. , Sarig, O. , Harmon, R. M. , Rapaport, D. , Ishida-Yamamoto, A. , Isakov, O. , Koetsier, J. L. , Gat, A. , Goldberg, I. , Bergman, R. , Spiegel, R. , Eytan, O. , Geller, S. , Peleg, S. , Shomron, N. , Goh, C. S. M. , Wilson, N. J. , Smith, F. J. D. , Pohler, E. , Simpson, M. A. & 6 others McLean, W. H. I., Irvine, A. D., Horowitz, M., McGrath, J. A., Green, K. J. & Sprecher, E. 2013 In : Nature Genetics.

    Research output: Contribution to journalLetter

  18. Detecting and quantifying p53 isoforms at mRNA level in cell lines and tissues

    Khoury, M. P., Marcel, V., Fernandes, K., Diot, A., Lane, D. P. & Bourdon, J-C. 2013 p53 protocols. Deb, S. & Deb, S. P. (eds.). Totowa, N.J.: Humana Press, Vol. 962, p. 1-14 14 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  19. Detecting p53 isoforms at protein level

    Marcel, V., Khoury, M. P., Fernandes, K., Diot, A., Lane, D. P. & Bourdon, J-C. 2013 p53 protocols. Deb, S. & Deb, S. P. (eds.). Totowa, N.J.: Humana Press, Vol. 962, p. 15-29 15 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  20. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

    MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S. & Tauro, S. 2013 In : Scientific Reports. 3, 1275

    Research output: Contribution to journalArticle

  21. Heterozygous loss-of-function mutations in the AAGAB gene cause punctate palmoplantar keratoderma type 1 and impair receptor tyrosine kinase protein turnover

    Pohler, E., Harkins, C., Salas, J., Zamiri, M., Wilson, N. J., Smith, F. J., Brown, S. J. & McLean, I. 2013 In : Journal of Investigative Dermatology. 133, S1, p. S146 1 p.863

    Research output: Contribution to journalMeeting abstract

  22. Multiple self-healing squamous epithelioma (MSSE): rare variants in an adjacent region of chromosome 9q22.3 to Known TGFBR1 mutations suggest a digenic or multilocus etiology

    Chung Kang, H., Quigley, D. A., Kim, I-J., Wakabayashi, Y., Ferguson-Smith, M. A., D'Alessandro, M., Lane, B., Akhurst, R. J., Goudie, D. R. & Balmain, A. 2013 In : Journal of Investigative Dermatology. 133, 7, p. 1907-1910 4 p.

    Research output: Contribution to journalArticle

  23. Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma

    Brown, S. J. & 31 others Pohler, E., Mamai, O., Hirst, J., Zamiri, M., Horn, H., Nomura, T., Irvine, A. D., Moran, B., Wilson, N. J., Smith, F. J. D., Goh, C. S. M., Sandilands, A., Cole, C., Barton, G. J., Evans, A. T., Shimizu, H., Akiyama, M., Suehiro, M., Konohana, I., Shboul, M., Teissier, S., Boussofara, L., Denguezli, M., Saad, A., Gribaa, M., Dopping-Hepenstal, P. J., McGrath, J. A., Goudie, D. R., Reversade, B., Munro, C. S. & McLean, W. H. I. Nov 2012 In : Nature Genetics. 44, 11, p. 1272-1276 5 p.

    Research output: Contribution to journalArticle

  24. Haploinsufficiency for alpha- and gamma-adaptin binding protein (AAGAB) p34 causes clinically heterogeneous forms of punctate palmoplantar keratoderma

    Pohler, E., Mamai, O., Hirst, J., Zamiri, M., Horn, H., Irvine, A. D., Nomura, T., McGrath, J. A., Munro, C. S. & McLean, W. Sep 2012 In : Journal of Investigative Dermatology. 132, p. S89-S89 1 p.

    Research output: Contribution to journalMeeting abstract

  25. Influenza A viruses control expression of proviral human p53 isoforms p53β and Delta133p53α

    Terrier, O., Marcel, V., Cartet, G., Lane, D. P., Lina, B., Rosa-Calatrava, M. & Bourdon, J-C. Aug 2012 In : Journal of Virology. 86, 16, p. 8452-8460 9 p.

    Research output: Contribution to journalArticle

  26. Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin

    Sandilands, A., Brown, S. J., Goh, C. S., Pohler, E., Wilson, N. J., Campbell, L. E., Miyamoto, K., Kubo, A., Irvine, A. D., Thawer-Esmail, F., Munro, C. S., McLean, W. H. I., Kudoh, J., Amagai, M. & Matsui, T. May 2012 In : Journal of Investigative Dermatology. 132, 5, p. 1507-1510 4 p.

    Research output: Contribution to journalLetter

  27. The p53 isoforms are differentially modified by Mdm2

    Camus, S., Menendez, S., Fernandes, K., Kua, N., Liu, G., Xirodimas, D. P., Lane, D. P. & Bourdon, J-C. 15 Apr 2012 In : Cell Cycle. 11, 8, p. 1646-1655 10 p.

    Research output: Contribution to journalArticle

  28. Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect

    Brown, S. J., Kroboth, K., Sandilands, A., Campbell, L. E., Pohler, E., Kezic, S., Cordell, H. J., McLean, W. H. I. & Irvine, A. D. Jan 2012 In : Journal of Investigative Dermatology. 132, 1, p. 98-104 7 p.

    Research output: Contribution to journalArticle

  29. C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances

    Muller, P., Ruckova, E., Halada, P., Coates, P. J., Hrstka, R., Lane, D. P. & Vojtesek, B. 2012 In : Oncogene.

    Research output: Contribution to journalArticle

  30. Diverse p63 and p73 isoforms regulate Delta 133p53 expression through modulation of the internal TP53 promoter activity

    Marcel, V., Petit, I., Murray-Zmijewski, F., Goullet De Rugy, T., Fernandes, K., Meuray, V., Diot, A., Lane, D. P., Aberdam, D. & Bourdon, J-C. 2012 In : Cell Death & Differentiation. 19, 5, p. 816-826 11 p.

    Research output: Contribution to journalArticle

  31. Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

    Ng, Y-Z., Pourreyron, C., Salas-Alanis, J. C., Dayal, J. H. S., Cepeda-Valdes, R., Yan, W., Wright, S., Chen, M., Fine, J-D., Hogg, F. J., McGrath, J. A., Murrell, D. F., Leigh, I. M., Lane, E. B. & South, A. P. 2012 In : Cancer Research. 72, 14, p. 3522-3534 13 p.

    Research output: Contribution to journalArticle

  32. Heterogeneity of p53-pathway Protein Expression in Chemosensitive Chronic Lymphocytic Leukemia: A Pilot Study

    Groves, M. J., Maccallum, S. F., Boylan, M. T., Haydock, S., Cunningham, J., Gelly, K., Gowans, D., Kerr, R., Coates, P. J. & Tauro, S. 2012 In : Journal of Cancer. 3, p. 354-361 8 p.

    Research output: Contribution to journalArticle

  33. Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant

    Morris, A. D. & 21 others Palmer, C. N. A., Maglio, C., Pirazzi, C., Burza, M. A., Adiels, M., Burch, L., Donnelly, L. A., Colhoun, H., Doney, A. S., Dillon, J. F., Pearson, E. R., McCarthy, M., Hattersley, A. T., Frayling, T., Peltonen, M., Svensson, P-A., Jacobson, P., Borén, J., Sjöström, L., Carlsson, L. M. S. & Romeo, S. 2012 In : PLoS ONE. 7, 6, e39362

    Research output: Contribution to journalArticle

  34. Scanning Ion Conductance Microscopy of Live Keratinocytes

    Hegde, V., Mason, A., Saliev, T., Smith, F., McLean, W. H. I. & Campbell, P. A. 2012 Electron Microscopy and Analysis Group Conference 2011 (EMAG 2011). Bristol: Institute of Physics, p. - 4 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  35. The mechanical behavior of mutant K14-R125P keratin bundles and networks in NEB-1 keratinocytes

    Beriault, D. R., Haddad, O., McCuaig, J. V., Robinson, Z. J., Russell, D., Lane, E. B. & Fudge, D. S. 2012 In : PLoS ONE. 7, 2, p. - 10 p.e31320

    Research output: Contribution to journalArticle

  36. Advances in bacterial transcriptome and transposon insertion-site profiling using second-generation sequencing

    Febrer, M., McLay, K., Caccamo, M., Twomey, K. B. & Ryan, R. . P. 1 Nov 2011 In : Trends in Biotechnology. 29, 11, p. 586-594 9 p.

    Research output: Contribution to journalScientific review

  37. Extracellular matrix composition in dermal microenvironment is implicated in development of life threatening cutaneous squamous cell carcinoma

    Ng, Y. Z., Pourreyron, C., Salas-Alanis, J. C., Murrell, D. F., McGrath, J. A., Lane, E. B. & South, A. P. Sep 2011 In : Journal of Investigative Dermatology. 131, p. S32-S32 1 p.190

    Research output: Contribution to journalBook/Film/Article review

  38. Primary cutaneous CD8-positive T-cell Lymphoma: a case report of a rare and aggressive disease with oral presentation

    Geddes, A., Savin, J., White, S. & Gibson, J. Sep 2011 In : Dental Update. 38, 7, p. 472-4, 476 4 p.

    Research output: Contribution to journalArticle

  39. Keratin 14-Null Cells as a Model to Test the Efficacy of Gene Therapy Approaches in Epithelial Cells

    D'Alessandro, M., Coats, S. E., Jonkmann, M. F., Leigh, I. M. & Lane, B. Jul 2011 In : Journal of Investigative Dermatology. 131, 7, p. 1412-1419 8 p.

    Research output: Contribution to journalArticle

  40. Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations

    Chen, H., Common, J. E. A., Haines, R. L., Balakrishnan, A., Brown, S. J., Goh, C. S. M., Cordell, H. J., Sandilands, A., Campbell, L. E., Kroboth, K., Irvine, A. D., Goh, D. L. M., Tang, M. B. Y., van Bever, H. P., Giam, Y. C., McLean, W. H. I. & Lane, E. B. Jul 2011 In : British Journal of Dermatology. 165, 1, p. 106-114 9 p.

    Research output: Contribution to journalArticle

  41. Filaggrin null mutations are not a protective factor for acne vulgaris

    Common, J. E. A., Brown, S. J., Haines, R. L., Goh, C. S. M., Chen, H., Balakrishnan, A., Munro, C. S., Tan, A. W. H., Tan, H. H., Tang, M. B. Y. & Lane, E. B. Jun 2011 In : Journal of Investigative Dermatology. 131, 6, p. 1378-1380 3 p.

    Research output: Contribution to journalLetter

  42. Statins downregulate K6a promoter activity: a possible therapeutic avenue for pachyonychia congenita

    Zhao, Y., Gartner, U., Smith, F. J. D. & McLean, W. H. I. May 2011 In : Journal of Investigative Dermatology. 131, 5, p. 1045-1052 8 p.

    Research output: Contribution to journalArticle

  43. Copy number variation within the filaggrin gene contributes to risk of atopic dermatitis

    Brown, S. J., Kroboth, K., Sandilands, A., Campbell, L. E., Pohler, E., Irvine, A. D., Cordell, H. J. & McLean, W. Apr 2011 In : Journal of Investigative Dermatology. 131, Supplement 1, p. S63-S63 1 p.375

    Research output: Contribution to journalBook/Film/Article review

  44. Developing small molecule drugs to rescue nonsense mutations in disease-causing genes

    Nomura, T., Gartner, U., McElroy, S., Torrie, L., Pourreyron, C., South, A. P., Wood, G., Woodland, A., Frearson, J., Wyatt, P. & McLean, I. Apr 2011 In : Journal of Investigative Dermatology. 131, p. S67-S67 1 p.397

    Research output: Contribution to journalBook/Film/Article review

  45. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

    Morris, A. D. , Sutherland, C. & 49 others Zhou, K., Bellenguez, C., Spencer, C. C. A., Bennett, A. J., Coleman, R. L., Tavendale, R., Hawley, S. A., Donnelly, L. A., Schofield, C., Groves, C. J., Burch, L., Carr, F., Strange, A., Freeman, C., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Craddock, N., Deloukas, P., Dronov, S., Duncanson, A., Edkins, S., Gray, E., Hunt, S., Jankowski, J., Langford, C., Markus, H. S., Mathew, C. G., Plomin, R., Rautanen, A., Sawcer, S. J., Samani, N. J., Trembath, R., Viswanathan, A. C., Wood, N. W., Harries, L. W., Hattersley, A. T., Doney, A. S. F., Colhoun, H., Hardie, D. G., Peltonen, L., McCarthy, M. I., Holman, R. R., Palmer, C. N. A., Donnelly, P., Pearson, E. R. & Wellcome Trust Case Control Consor, GoDARTS UKPDS Diabet Pharmacogenet, MAGIC Investigators Feb 2011 In : Nature Genetics. 43, 2, p. 117-120 4 p.

    Research output: Contribution to journalLetter

  46. p53 directly transactivates Delta 133p53 alpha, regulating cell fate outcome in response to DNA damage

    Aoubala, M., Murray-Zmijewski, F., Khoury, M. P., Fernandes, K., Perrier, S., Bernard, H., Prats, A-C., Lane, D. P. & Bourdon, J-C. Feb 2011 In : Cell Death & Differentiation. 18, 2, p. 248-258 11 p.

    Research output: Contribution to journalArticle

  47. Cyp2c8 variant reduce the therapeutic response to thiazolidinediones - a godarts study

    Zhou, K., Burch, L., Vella, S., Palmer, C. N. A. & Pearson, E. R. Sep 2010 In : Diabetologia. 53, p. S133-S133 1 p.

    Research output: Contribution to journalBook/Film/Article review

  48. Tumour microenvironment is implicated by dermal fibroblast expression profiling in the development of aggressive squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

    Ng, Y. Z., Pourreyron, C., Salas-Alanis, J. C., Murrell, D. F., McGrath, J. A., Lane, E. B., Leigh, I. & South, A. Sep 2010 In : Journal of Investigative Dermatology. 130, p. S83-S83 1 p.

    Research output: Contribution to journalBook/Film/Article review

  49. Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults

    Mukhopadhyay, S., Sypek, J., Tavendale, R., Gartner, U., Winter, J., Li, W., Page, K., Fleming, M., Brady, J., O'Toole, M., Macgregor, D. F., Goldman, S., Tam, S., Abraham, W., Williams, C., Miller, D. K. & Palmer, C. N. A. Jul 2010 In : Journal of Allergy and Clinical Immunology. 126, 1, p. 70-76 7 p.

    Research output: Contribution to journalArticle

  50. Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors

    Wang, S. , Midgley, C. A. , Scaërou, F. , Grabarek, J. B. , Griffiths, G. , Jackson, W. , Kontopidis, G. , McClue, S. J. , McInnes, C. , Meades, C. , Mezna, M. , Plater, A. , Stuart, I. , Thomas, M. P. , Wood, G. , Clarke, R. G. , Blake, D. G. , Zheleva, D. I. , Lane, D. P. , Jackson, R. C. & 2 others Glover, D. M. & Fischer, P. M. 10 Jun 2010 In : Journal of Medicinal Chemistry. 53, 11, p. 4367-4378 12 p.

    Research output: Contribution to journalArticle

  51. PPARG, insulin resistance and metformin pharmacogenetics-A GoDARTS study

    Zhou, K., Burch, L., Hattersley, A. T., McCarthy, M. I., Morris, A. D., Palmer, C. N. A. & Pearson, E. R. Jun 2010 In : Diabetes. 59, p. A115-A115 1 p.

    Research output: Contribution to journalBook/Film/Article review

  52. Additional genes involved in epidermolysis bullosa simplex

    Pohler, E., Terron-Kwiatkowski, A., Baty, D. U., Mellerio, J. E. & McLean, W. H. I. Apr 2010 In : British Journal of Dermatology. 162, 4, p. 939-940 2 p.P34

    Research output: Contribution to journalBook/Film/Article review

  53. Dermal fibroblast expression profiling implicates tumour microenvironment in the development of aggressive squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

    Ng, Y. Z., Pourreyron, C., Proby, C., Salas, J., Murrell, D. F., McGrath, J. A., Lane, E. B., Leigh, I. M. & South, A. P. Apr 2010 In : British Journal of Dermatology. 162, 4, p. 948-948 1 p.

    Research output: Contribution to journalBook/Film/Article review

  54. Immunohistochemical localization of cellular NFATc1 does not predict clinical responses to ciclosporin in subcutaneous panniculitis-like T-cell non-Hodgkin lymphoma

    Tauro, S., MacCallum, S., Groves, M. J., Rojnuckarin, P., Assanasen, T., Feldman, A. L., Robson, A., Marschalko, M., Kini, H., Alzolibani, A. A., Al Robaee, A., Al Shobaili, H. A., Alfawzan, S., Goodlad, J. R., Kernohan, N., Hummel, M., Sterry, W. & Assaf, C. Apr 2010 In : British Journal of Dermatology. 162, 4, p. 887-889 3 p.

    Research output: Contribution to journalLetter

  55. Peroxisome proliferator-activated receptor-delta genotype influences metabolic phenotype and may Influence lipid response to statin therapy in humans: A genetics of diabetes audit and research Tayside study

    Burch, L. R., Donnelly, L. A., Doney, A. S. F., Brady, J., Tommasi, A. M., Whitley, A. L., Goddard, C., Morris, A. D., Hansen, M. K. & Palmer, C. N. A. Apr 2010 In : Journal of Clinical Endocrinology & Metabolism. 95, 4, p. 1830-1837 8 p.

    Research output: Contribution to journalArticle

  56. Keratin K6c mutations cause focal palmoplantar keratoderma

    Wilson, N. J., Messenger, A. G., Leachman, S. A., O'Toole, E. A., Lane, E. B., McLean, W. H. I. & Smith, F. J. D. Feb 2010 In : Journal of Investigative Dermatology. 130, 2, p. 425-429 5 p.

    Research output: Contribution to journalArticle

  57. MdmX is a substrate for the deubiquitinating enzyme USP2a

    Allende-Vega, N., Sparks, A., Lane, D. P. & Saville, M. K. 21 Jan 2010 In : Oncogene. 29, 3, p. 432-441 10 p.

    Research output: Contribution to journalArticle

  58. Loss-of-function CYP2C9 variants improve therapeutic response to sulfonylureas in type 2 diabetes: A Go-DARTS study

    Zhou, K., Donnelly, L., Burch, L., Tavendale, R., Doney, A. S. F., Leese, G., Hattersley, A. T., McCarthy, M. I., Morris, A. D., Lang, C. C., Palmer, C. N. A. & Pearson, E. R. Jan 2010 In : Clinical Pharmacology & Therapeutics. 87, 1, p. 52-56 5 p.

    Research output: Contribution to journalArticle

  59. A wide spectrum of filaggrin mutations contribute to ichthyosis vulgaris and atopic dermatitis in the Singaporean Chinese population

    Chen, H., Common, J. E. A., Haines, R. L., Balakrishnan, A., Goh, C. S. M., Goh, D. M. L., Tang, M. B. Y., Van Bever, H. P., Giam, Y. C., McLean, W. H. I. & Lane, E. B. 2010 In : Journal of Investigative Dermatology. 130, p. S94 1 p.564

    Research output: Contribution to journalBook/Film/Article review

  60. Late simultaneous metastasis of renal cell carcinoma to the submandibular and thyroid glands seven years after radical nephrectomy

    Miah, M., White, S., Oommen, G., Birney, E. & Majumdar, S. 2010 In : International Journal of Otolaryngology. 4 p.698014

    Research output: Contribution to journalArticle

  61. Steatocystoma multiplex, oligodontia and partial persistent primary dentition associated with a novel keratin 17 mutation

    Gass, J. K., Wilson, N. J., Smith, F. J. D., Lane, E. B., McLean, W. H. I. M., Rytina, E., Salvary, I. & Burrows, N. P. Dec 2009 In : British Journal of Dermatology. 161, 6, p. 1396-1398 3 p.

    Research output: Contribution to journalArticle

  62. A single nucleotide polymorphism on Exon-4 of the gene encoding PPAR delta is associated with reduced height inadults and children

    Burch, L. R., Zhou, K., Donnelly, L. A., Doney, A. S. F., Brady, J., Goddard, C., Morris, A. D., Hansen, M. K. & Palmer, C. N. A. Jul 2009 In : Journal of Clinical Endocrinology & Metabolism. 94, 7, p. 2587-2593 7 p.

    Research output: Contribution to journalArticle

  63. Association of skin barrier genes within the PSORS4 locus is enriched in Singaporean Chinese with early-onset psoriasis

    Chen, H., Toh, T. K. L., Szeverenyi, I., Ong, R. T. H., Theng, C. T. S., McLean, W. H. I., Seielstad, M. & Lane, E. B. 1 Mar 2009 In : Journal of Investigative Dermatology. 129, 3, p. 606-614 9 p.

    Research output: Contribution to journalArticle

  64. The annexin-V assay reflects susceptibility to in vitro membrane damage in chronic lymphocytic leukemia and may overestimate cell death

    Groves, M. J., MacCallum, S., Boylan, M. T., Coates, P. J. & Tauro, S. Mar 2009 In : American Journal of Hematology. 84, 3, p. 196-197 2 p.

    Research output: Contribution to journalLetter

  65. Suppression of the Deubiquitinating Enzyme USP5 Causes the Accumulation of Unanchored Polyubiquitin and the Activation of p53

    Dayal, S., Sparks, A., Jacob, J., Allende-Vega, N., Lane, D. & Saville, M. K. 20 Feb 2009 In : Journal of Biological Chemistry. 284, 8, p. 5030-5041 12 p.

    Research output: Contribution to journalArticle

  66. Autoimmune pancytopenia following combination chemotherapy for chronic lymphocytic leukaemia

    MacCallum, S., Groves, M., Brass, D., Cunningham, J., Sales, M., Gelly, K. & Tauro, S. 2009 In : Journal of Clinical Pathology. 62, 5, p. 468-470 3 p.

    Research output: Contribution to journalArticle

  67. Characterization, chemical optimization and anti-tumour activity of a tubulin poison identified by a p53-based phenotypic screen

    Staples, O. D., Hollick, J. J., Campbell, J., Higgins, M., McCarthy, A. R., Appleyard, V., Murray, K. E., Baker, L., Thompson, A., Ronseaux, S., Slawin, A. M. Z., Lane, D. P., Westwood, N. J. & Lain, S. 1 Nov 2008 In : Cell Cycle. 7, 21, p. 3417-3427 11 p.

    Research output: Contribution to journalArticle

  68. Targeting a nucleolar SUMO protease for degradation: a mechanism by which ARF induces SUMO conjugation

    Xirodimas, D. P. & Lane, D. P. 1 Nov 2008 In : Cell Cycle. 7, 21, p. 3287-3288 2 p.

    Research output: Contribution to journalArticle

  69. Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita

    Leachman, S. A., Hickerson, R. P., Hull, P. R., Smith, F. J. D., Milstone, L. M., Lane, E. B., Bale, S. J., Roop, D. R., McLean, W. H. I. & Kaspar, R. L. Sep 2008 In : Journal of Dermatological Science. 51, 3, p. 151-157 7 p.

    Research output: Contribution to journalScientific review

  70. Unique and recurrent mutations in the filaggrin gene in Singaporean Chinese patients with ichthyosis vulgaris

    Chen, H., Ho, J. C. C., Sandilands, A., Chan, Y. C., Giam, Y. C., Evans, A. T., Lane, E. B. & McLean, W. H. I. Jul 2008 In : Journal of Investigative Dermatology. 128, 7, p. 1669-1675 7 p.

    Research output: Contribution to journalArticle

  71. Discovery, in vivo activity and mechanism of action of a small-molecule p53 activator

    Lain, S., Hollick, J. J., Campbell, J., Staples, O. D., Higgins, M., Aoubala, M., McCarthy, A., Appleyard, V., Murray, K. E., Baker, L., Thompson, A., Mathers, J., Holland, S. J., Stark, M. J. R., Pass, G., Woods, J., Lane, D. P. & Westwood, N. J. 6 May 2008 In : Cancer Cell. 13, 5, p. 454-463 10 p.

    Research output: Contribution to journalArticle

  72. Keratin K6c mutations cause focal keratoderma

    Wilson, N. J., Messenger, A. G., Leachmin, S. A., Lane, E. B., McLean, W. & Smith, F. J. Apr 2008 In : Journal of Investigative Dermatology. 128, p. S127-S127 1 p.Abstract 757

    Research output: Contribution to journalBook/Film/Article review

  73. p53 activating benzoyl urea and benzoyl thiourea compounds

    Lain, S., Lane, D., Stark, M. J. R., McCarthy, A. R., Hollick, J. J. & Westwood, N. J. 13 Mar 2008 WO2008029096

    Research output: Patent

  74. Broken bricks and cracked mortar - epidermal diseases resulting from genetic abnormalities

    Lane, E. B. & McLean, W. H. I. 1 Mar 2008 In : Drug Discovery Today: Disease Mechanisms. 5, 1

    Research output: Contribution to journalArticle

  75. The human intermediate filament database: Comprehensive information on a gene family involved in many human diseases

    Szeverenyi, I. , Cassidy, A. J. , Chung, C. W. , Lee, B. T. K. , Common, J. E. A. , Ogg, S. C. , Chen, H. , Sim, S. Y. , Goh, W. L. R. , Ng, K. W. , Simpson, J. A. , Chee, L. L. , Eng, G. H. , Li, B. , Lunny, D. P. , Chuon, D. , Venkatesh, A. , Khoo, K. H. , McLean, W. H. I. , Lim, Y. P. & 1 others Lane, E. B. Mar 2008 In : Human Mutation. 29, 3, p. 351-360 10 p.

    Research output: Contribution to journalArticle

  76. Dual-specificity phosphatases in the hypo-osmotic stress response of keratin-defective epithelial cell lines

    Liovic, M., Lee, B., Tomic-Canic, M., D'Alessandro, M., Bolshakov, V. N. & Lane, E. B. 2008 In : Experimental Cell Research. 314, 10, p. 2066-2075 10 p.

    Research output: Contribution to journalArticle

  77. Steatocystoma multiplex and persistent primary dentition due to a novel keratin 17 mutation

    Gass, J. K., Wilson, N. J., Smith, E. B. F., Lane, B., McLean, W. H. I., Salvary, I. & Burrows, N. P. 2008 In : British Journal of Dermatology. 159, S1, p. 119 1 p.PA-13

    Research output: Contribution to journalBook/Film/Article review

  78. Toward an improved prediction of human in vivo brain penetration

    Summerfield, S. G., Lucas, A. J., Porter, R. A., Jeffrey, P., Gunn, R. N., Read, K. R., Stevens, A. J., Metcalf, A. C., Osuna-Cabello, M. C., Kilford, P. J., Passchier, J. & Ruffo, A. D. 2008 In : Xenobiotica. 38, 12, p. 1518-1535 18 p.

    Research output: Contribution to journalArticle

  79. A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita

    Liao, H., Sayers, J. M., Wilson, N. J., Irvine, A. D., Mellerio, J. E., Baselga, E., Bayliss, S. J., Uliana, V., Fimiani, M., Lane, E. B., McLean, W. H. I., Leachman, S. A. & Smith, F. J. D. Dec 2007 In : Journal of Dermatological Science. 48, 3, p. 199-205 7 p.

    Research output: Contribution to journalArticle

  80. Novel Mdm2 intron 1 single nucleotide polymorphisms and their role in breast cancer

    Paulin, F., O'Neill, M., McGregor, G., Cassidy, A., Ashfield, A., Ali, C. W., Baker, L., Munro, A. J., Lane, D. & Thompson, A. M. Dec 2007 In : Breast Cancer Research and Treatment. 106, p. S285-S285 1 p.6114

    Research output: Contribution to journalBook/Film/Article review

  81. Multiple self-healing squamous epithelioma in different ethnic groups: more than a founder mutation disorder?

    D'Alessandro, M., Coats, S. E., Morley, S. M., Mackintosh, L., Tessari, G., Turco, A., Gerdes, A-M., Pichert, G., Whittaker, S., Brandrup, F., Broesby-Olsen, S., Gomez-Lira, M., Girolomoni, G., Maize, J. C., Feldman, R. J., Kato, N., Koga, Y., Ferguson-Smith, M. A., Goudie, D. R. & Lane, E. B. Oct 2007 In : Journal of Investigative Dermatology. 127, 10, p. 2336-44 9 p.

    Research output: Contribution to journalArticle

  82. Epidermolysis bullosa simplex in Scotland caused by a spectrum of keratin mutations

    Rugg, E. L., Horn, H. M., Smith, F. J., Wilson, N. J., Hill, A. J. M., Magee, G. J., Shemanko, C. S., Baty, D. U., Tidman, M. J. & Lane, E. B. 2007 In : Journal of Investigative Dermatology. 127, 3, p. 574-80 7 p.

    Research output: Contribution to journalArticle

  83. The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

    Stevenson, L. F., Sparks, A., Allende-Vega, N., Xirodimas, D. P., Lane, D. & Saville, M. K. 2007 In : The EMBO Journal. 26, 4, p. 976-986 11 p.

    Research output: Contribution to journalArticle

  84. Ubiquitin-independent degradation of p53 mediated by high-risk human papillomavirus protein E6

    Camus, S., Menendez, S., Cheok, C. F., Stevenson, L. F., Lain, S. & Lane, D. P. 2007 In : Oncogene. 26, 28, p. 4059-4070 12 p.

    Research output: Contribution to journalArticle

  85. p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress

    Murray-Zmijewski, F., Lane, D. & Bourdon, J-C. Jun 2006 In : Cell Death & Differentiation. 13, 6, p. 962-972 11 p.

    Research output: Contribution to journalScientific review

  86. Tumor susceptibility and apoptosis defect in a mouse strain expressing a human p53 transgene

    Dudgeon, C., Kek, C., Demidov, O. N., Saito, S., Fernandes, K., Diot, A., Bourdon, J-C., Lane, D. P., Appella, E., Fornace , A. J. & Bulavin, D. V. 15 Mar 2006 In : Cancer Research. 66, 6, p. 2928-2936 9 p.

    Research output: Contribution to journalArticle

  87. A functional analysis of PCNA-binding peptides derived from protein sequence, interaction screening and rational design

    Warbrick, E. 2006 In : Oncogene. 25, 20, p. 2850-2859 10 p.

    Research output: Contribution to journalArticle

  88. The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury

    Darragh, J., Hunter, M., Pohler, E., Nelson, L., Dillon, J. F., Nenutil, R., Vojtesek, B., Ross, P. E., Kernohan, N. & Hupp, T. R. 2006 In : FEBS Journal. 273, 9, p. 1930-1947 18 p.

    Research output: Contribution to journalArticle

  89. The p66 and p12 subunits of DNA polymerase δ are modified by ubiquitin and ubiquitin-like proteins

    Liu, G. & Warbrick, E. 2006 In : Biochemical and Biophysical Research Communications. 349, 1, p. 360-366 7 p.

    Research output: Contribution to journalArticle

  90. Loss of function of def selectively up-regulates Δ113p53 expression to arrest expansion growth of digestive organs in zebrafish

    Chen, J., Ruan, H., Ng, S. M., Gao, C., Soo, H. M., Wu, W., Zhang, Z., Wen, Z., Lane, D. & Peng, J. Dec 2005 In : Genes & Development. 19, 23, p. 2900-2911 12 p.

    Research output: Contribution to journalArticle

  91. p53 isoforms can regulate p53 transcriptional activity

    Bourdon, J. C., Fernandes, K., Murray-Zmijewski, F., Liu, G., Diot, A., Xirodimas, D. P., Saville, M. K. & Lane, D. P. 15 Sep 2005 In : Genes & Development. 19, 18, p. 2122-2137 16 p.

    Research output: Contribution to journalArticle

  92. The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor

    Bates, G. J., Nicol, S. M., Wilson, B. J., Jacobs, A-M. F., Bourdon, J-C., Wardrop, J., Gregory, D. J., Lane, D. P., Perkins, N. D. & Fuller-Pace, F. V. 9 Feb 2005 In : The EMBO Journal. 24, 3, p. 543-553 11 p.

    Research output: Contribution to journalArticle

  93. P53 abnormalities and outcomes in colorectal cancer: a systematic review

    Munro, A. J., Lain, S. & Lane, D. P. Feb 2005 In : British Journal of Cancer. 92, 3, p. 434-444 11 p.

    Research output: Contribution to journalArticle

  94. An in vivo analysis of the localisation and interactions of human p66 DNA polymerase δ subunit

    Pohler, J. R. G., Otterlei, M. & Warbrick, E. 2005 In : BMC Molecular Biology. 6, 1, p. 17-30 14 p.

    Research output: Contribution to journalArticle

  95. Pilot screening programme for small molecule activators of p53

    Berkson, R. G., Hollick, J. J., Westwood, N. J., Woods, J. A., Lane, D. P. & Lain, S. 2005 In : International Journal of Cancer. 115, 5, p. 701-710 10 p.

    Research output: Contribution to journalArticle

  96. Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo

    Saville, M. K., Sparks, A., Xirodimas, D. P., Wardrop, J., Stevenson, L. F., Bourdon, J-C., Woods, Y. L. & Lane, D. P. 1 Oct 2004 In : Journal of Biological Chemistry. 279, 40, p. 42169-42181 13 p.

    Research output: Contribution to journalArticle

  97. Mechanical stress induces profound remodelling of keratin filaments and cell junctions in epidermolysis bullosa simplex keratinocytes

    Russell, D., Andrews, P. D., James, J. & Lane, E. B. Oct 2004 In : Journal of Cell Science. 117, 22, p. 5233-5243 11 p.

    Research output: Contribution to journalArticle

  98. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

    Xirodimas, D. P., Saville, M. K., Bourdon, J. C., Hay, R. T. & Lane, D. P. 9 Jul 2004 In : Cell. 118, 1, p. 83-97 15 p.

    Research output: Contribution to journalArticle

  99. Human keratin 8 mutations that disturb filament assembly observed in inflammatory bowel disease patients

    Owens, D. W., Wilson, N. J., Hill, A. J. M., Rugg, E. L., Porter, R. M., Hutcheson, A. M., Quinlan, R. A., van Heel, D., Parkes, M., Jewell, D. P., Campbell, S. S., Ghosh, S., Satsangi, J. & Lane, E. B. Apr 2004 In : Journal of Cell Science. 117, 10, p. 1989-1999 11 p.

    Research output: Contribution to journalArticle

  100. Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1

    Burch, L. R., Scott, M., Pohler, E., Meek, D. & Hupp, T. 12 Mar 2004 In : Journal of Molecular Biology. 337, 1, p. 115-128 14 p.

    Research output: Contribution to journalArticle

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