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  1. Reliability and validity of genotyping filaggrin null mutations

    Margolis, D. J., Apter, A. J., Mitra, N., Gupta, J., Hoffstad, O., Papadopoulos, M., Rebbeck, T. R., MacCallum, S., Campbell, L. E., Sandilands, A. & McLean, W. H. I. Apr-2013 In : Journal of Dermatological Science. 70, 1, p. 67-68, 2 p.

    Research output: Contribution to journal › Letter

  2. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

    MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S. & Tauro, S. 1-Jan-2013 In : Scientific Reports. 3, 1275

    Research output: Contribution to journal › Article

  3. Allele-specific siRNA silencing for the common keratin 12 founder mutation in Meesmann epithelial corneal dystrophy

    Allen, E. H. A., Atkinson, S. D., Liao, H., Moore, J. E., Pedrioli, D. M. L., Smith, F. J. D., McLean, W. H. I. & Moore, C. B. T. 2013 In : Investigative Ophthalmology & Visual Science. 54, 1, p. 494-502, 9 p.

    Research output: Contribution to journal › Article

  4. Detecting and quantifying p53 isoforms at mRNA level in cell lines and tissues

    Khoury, M. P., Marcel, V., Fernandes, K., Diot, A., Lane, D. P. & Bourdon, J-C. 2013 p53 protocols. Deb, S. & Deb, S. P. (eds.). Totowa, N.J.: Humana Press, Vol. 962, p. 1-14 14 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

  5. Detecting p53 isoforms at protein level

    Marcel, V., Khoury, M. P., Fernandes, K., Diot, A., Lane, D. P. & Bourdon, J-C. 2013 p53 protocols. Deb, S. & Deb, S. P. (eds.). Totowa, N.J.: Humana Press, Vol. 962, p. 15-29 15 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

  6. Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma

    Pohler, E. , Mamai, O. , Hirst, J. , Zamiri, M. , Horn, H. , Nomura, T. , Irvine, A. D. , Moran, B. , Wilson, N. J. , Smith, F. J. D. , Goh, C. S. M. , Sandilands, A. , Cole, C. , Barton, G. J. , Evans, A. T. , Shimizu, H. , Akiyama, M. , Suehiro, M. , Konohana, I. , Shboul, M. & 12 others Teissier, S., Boussofara, L., Denguezli, M., Saad, A., Gribaa, M., Dopping-Hepenstal, P. J., McGrath, J. A., Brown, S. J., Goudie, D. R., Reversade, B., Munro, C. S. & McLean, W. H. I. Nov-2012 In : Nature Genetics. 44, 11, p. 1272-1276, 5 p.

    Research output: Contribution to journal › Article

  7. Haploinsufficiency for alpha- and gamma-adaptin binding protein (AAGAB) p34 causes clinically heterogeneous forms of punctate palmoplantar keratoderma

    Pohler, E., Mamai, O., Hirst, J., Zamiri, M., Horn, H., Irvine, A. D., Nomura, T., McGrath, J. A., Munro, C. A. & McLean, W. Sep-2012 In : Journal of Investigative Dermatology. 132, p. S89-S89, 1 p.

    Research output: Contribution to journal › Meeting abstract

  8. Influenza A viruses control expression of proviral human p53 isoforms p53β and Delta133p53α

    Terrier, O., Marcel, V., Cartet, G., Lane, D. P., Lina, B., Rosa-Calatrava, M. & Bourdon, J-C. Aug-2012 In : Journal of Virology. 86, 16, p. 8452-8460, 9 p.

    Research output: Contribution to journal › Article

  9. Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant

    Palmer, C. N. A. , Burch, L. , Donnelly, L. A. , Colhoun, H. , Doney, A. S. , Dillon, J. F. , Pearson, E. R. , Morris, A. D. , Maglio, C. , Pirazzi, C. , Burza, M. A. , Adiels, M. , Svensson, P-A. , Jacobson, P. , Borén, J. , Sjöström, L. , Carlsson, L. M. S. , Romeo, S. , McCarthy, M. , Hattersley, A. T. & 2 others Frayling, T. & Peltonen, M. 18-Jun-2012 In : PLoS ONE. 7, 6, e39362

    Research output: Contribution to journal › Article

  10. Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin

    Sandilands, A., Brown, S. J., Goh, C. S., Pohler, E., Wilson, N. J., Campbell, L. E., Miyamoto, K., Kubo, A., Irvine, A. D., Thawer-Esmail, F., Munro, C. S., McLean, W. H. I., Kudoh, J., Amagai, M. & Matsui, T. May-2012 In : Journal of Investigative Dermatology. 132, 5, p. 1507-1510, 4 p.

    Research output: Contribution to journal › Letter

  11. The p53 isoforms are differentially modified by Mdm2

    Camus, S., Menendez, S., Fernandes, K., Kua, N., Liu, G., Xirodimas, D. P., Lane, D. P. & Bourdon, J-C. 15-Apr-2012 In : Cell Cycle. 11, 8, p. 1646-1655, 10 p.

    Research output: Contribution to journal › Article

  12. Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect

    Brown, S. J., Kroboth, K., Sandilands, A., Campbell, L. E., Pohler, E., Kezic, S., Cordell, H. J., McLean, W. H. I. & Irvine, A. D. Jan-2012 In : Journal of Investigative Dermatology. 132, 1, p. 98-104, 7 p.

    Research output: Contribution to journal › Article

  13. C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances

    Muller, P., Ruckova, E., Halada, P., Coates, P. J., Hrstka, R., Lane, D. P. & Vojtesek, B. 2012 In : Oncogene.

    Research output: Contribution to journal › Article

  14. Diverse p63 and p73 isoforms regulate Delta 133p53 expression through modulation of the internal TP53 promoter activity

    Marcel, V., Petit, I., Murray-Zmijewski, F., Goullet De Rugy, T., Fernandes, K., Meuray, V., Diot, A., Lane, D. P., Aberdam, D. & Bourdon, J-C. 2012 In : Cell Death & Differentiation. 19, 5, p. 816-826, 11 p.

    Research output: Contribution to journal › Article

  15. Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

    Ng, Y-Z., Pourreyron, C., Salas-Alanis, J. C., Dayal, J. H. S., Cepeda-Valdes, R., Yan, W., Wright, S., Chen, M., Fine, J-D., Hogg, F. J., McGrath, J. A., Murrell, D. F., Leigh, I. M., Lane, E. B. & South, A. P. 2012 In : Cancer Research. 72, 14, p. 3522-3534, 13 p.

    Research output: Contribution to journal › Article

  16. Heterogeneity of p53-pathway Protein Expression in Chemosensitive Chronic Lymphocytic Leukemia: A Pilot Study

    Groves, M. J., Maccallum, S. F., Boylan, M. T., Haydock, S., Cunningham, J., Gelly, K., Gowans, D., Kerr, R., Coates, P. J. & Tauro, S. 2012 In : International Journal of Cancer. 3, p. 354-361, 8 p.

    Research output: Contribution to journal › Article

  17. Scanning Ion Conductance Microscopy of Live Keratinocytes

    Hegde, V., Mason, A., Saliev, T., Smith, F., McLean, W. H. I. & Campbell, P. A. 2012 Electron Microscopy and Analysis Group Conference 2011 (EMAG 2011). Bristol: Institute of Physics, p. - 4 p.

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  18. The mechanical behavior of mutant K14-R125P keratin bundles and networks in NEB-1 keratinocytes

    Beriault, D. R., Haddad, O., McCuaig, J. V., Robinson, Z. J., Russell, D., Lane, E. B. & Fudge, D. S. 2012 In : PLoS ONE. 7, 2, p. -, 10 p., e31320

    Research output: Contribution to journal › Article

  19. The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage

    Nicol, S. M., Bray, S. E., Derek Black, H., Lorimore, S. A., Wright, E. G., Lane, D. P., Meek, D. W., Coates, P. J. & Fuller-Pace, F. V. 2012 In : Oncogene.

    Research output: Contribution to journal › Article

  20. Primary cutaneous CD8-positive T-cell Lymphoma: a case report of a rare and aggressive disease with oral presentation

    Geddes, A., Savin, J., White, S. & Gibson, J. Sep-2011 In : Dental Update. 38, 7, p. 472-4, 476, 4 p.

    Research output: Contribution to journal › Article

  21. Keratin 14-Null Cells as a Model to Test the Efficacy of Gene Therapy Approaches in Epithelial Cells

    D'Alessandro, M., Coats, S. E., Jonkmann, M. F., Leigh, I. M. & Lane, B. Jul-2011 In : Journal of Investigative Dermatology. 131, 7, p. 1412-1419, 8 p.

    Research output: Contribution to journal › Article

  22. Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations

    Chen, H., Common, J. E. A., Haines, R. L., Balakrishnan, A., Brown, S. J., Goh, C. S. M., Cordell, H. J., Sandilands, A., Campbell, L. E., Kroboth, K., Irvine, A. D., Goh, D. L. M., Tang, M. B. Y., van Bever, H. P., Giam, Y. C., McLean, W. H. I. & Lane, E. B. Jul-2011 In : British Journal of Dermatology. 165, 1, p. 106-114, 9 p.

    Research output: Contribution to journal › Article

  23. Filaggrin null mutations are not a protective factor for acne vulgaris

    Common, J. E. A., Brown, S. J., Haines, R. L., Goh, C. S. M., Chen, H., Balakrishnan, A., Munro, C. S., Tan, A. W. H., Tan, H. H., Tang, M. B. Y. & Lane, E. B. Jun-2011 In : Journal of Investigative Dermatology. 131, 6, p. 1378-1380, 3 p.

    Research output: Contribution to journal › Letter

  24. Statins downregulate K6a promoter activity: a possible therapeutic avenue for pachyonychia congenita

    Zhao, Y., Gartner, U., Smith, F. J. D. & McLean, W. H. I. May-2011 In : Journal of Investigative Dermatology. 131, 5, p. 1045-1052, 8 p.

    Research output: Contribution to journal › Article

  25. Copy number variation within the filaggrin gene contributes to risk of atopic dermatitis

    Brown, S. J., Kroboth, K., Sandilands, A., Campbell, L. E., Pohler, E., Irvine, A. D., Cordell, H. J. & McLean, W. Apr-2011 In : Journal of Investigative Dermatology. 131, Supplement 1, p. S63-S63, 1 p., 375

    Research output: Contribution to journal › Book/Film/Article review

  26. Developing small molecule drugs to rescue nonsense mutations in disease-causing genes

    Nomura, T., Gartner, U., McElroy, S., Torrie, L., Pourreyron, C., South, A. P., Wood, G., Woodland, A., Frearson, J., Wyatt, P. & McLean, I. Apr-2011 In : Journal of Investigative Dermatology. 131, p. S67-S67, 1 p., 397

    Research output: Contribution to journal › Book/Film/Article review

  27. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

    Sutherland, C. & 50 others Zhou, K., Bellenguez, C., Spencer, C. C. A., Bennett, A. J., Coleman, R. L., Tavendale, R., Hawley, S. A., Donnelly, L. A., Schofield, C., Groves, C. J., Burch, L., Carr, F., Strange, A., Freeman, C., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Craddock, N., Deloukas, P., Dronov, S., Duncanson, A., Edkins, S., Gray, E., Hunt, S., Jankowski, J., Langford, C., Markus, H. S., Mathew, C. G., Plomin, R., Rautanen, A., Sawcer, S. J., Samani, N. J., Trembath, R., Viswanathan, A. C., Wood, N. W., Harries, L. W., Hattersley, A. T., Doney, A. S. F., Colhoun, H., Morris, A. D., Hardie, D. G., Peltonen, L., McCarthy, M. I., Holman, R. R., Palmer, C. N. A., Donnelly, P., Pearson, E. R. & Wellcome Trust Case Control Consor, GoDARTS UKPDS Diabet Pharmacogenet, MAGIC Investigators Feb-2011 In : Nature Genetics. 43, 2, p. 117-U57, 6 p.

    Research output: Contribution to journal › Article

  28. p53 directly transactivates Delta 133p53 alpha, regulating cell fate outcome in response to DNA damage

    Aoubala, M., Murray-Zmijewski, F., Khoury, M. P., Fernandes, K., Perrier, S., Bernard, H., Prats, A-C., Lane, D. P. & Bourdon, J-C. Feb-2011 In : Cell Death & Differentiation. 18, 2, p. 248-258, 11 p.

    Research output: Contribution to journal › Article

  29. Cyp2c8 variant reduce the therapeutic response to thiazolidinediones - a godarts study

    Zhou, K., Burch, L., Vella, S., Palmer, C. N. A. & Pearson, E. R. Sep-2010 In : Diabetologia. 53, p. S133-S133, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  30. Tumour microenvironment is implicated by dermal fibroblast expression profiling in the development of aggressive squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

    Ng, Y. Z., Pourreyron, C., Salas-Alanis, J. C., Murrell, D. F., McGrath, J. A., Lane, E. B., Leigh, I. & South, A. Sep-2010 In : Journal of Investigative Dermatology. 130, p. S83-S83, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  31. Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults

    Mukhopadhyay, S., Sypek, J., Tavendale, R., Gartner, U., Winter, J., Li, W., Page, K., Fleming, M., Brady, J., O'Toole, M., Macgregor, D. F., Goldman, S., Tam, S., Abraham, W., Williams, C., Miller, D. K. & Palmer, C. N. A. Jul-2010 In : Journal of Allergy and Clinical Immunology. 126, 1, p. 70-76, 7 p.

    Research output: Contribution to journal › Article

  32. Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors

    Wang, S. , Midgley, C. A. , Scaërou, F. , Grabarek, J. B. , Griffiths, G. , Jackson, W. , Kontopidis, G. , McClue, S. J. , McInnes, C. , Meades, C. , Mezna, M. , Plater, A. , Stuart, I. , Thomas, M. P. , Wood, G. , Clarke, R. G. , Blake, D. G. , Zheleva, D. I. , Lane, D. P. , Jackson, R. C. & 2 others Glover, D. M. & Fischer, P. M. 10-Jun-2010 In : Journal of Medicinal Chemistry. 53, 11, p. 4367-4378, 12 p.

    Research output: Contribution to journal › Article

  33. PPARG, insulin resistance and metformin pharmacogenetics-A GoDARTS study

    Zhou, K., Burch, L., Hattersley, A. T., McCarthy, M. I., Morris, A. D., Palmer, C. N. A. & Pearson, E. R. Jun-2010 In : Diabetes. 59, p. A115-A115, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  34. Additional genes involved in epidermolysis bullosa simplex

    Pohler, E., Terron-Kwiatkowski, A., Baty, D. U., Mellerio, J. E. & McLean, W. H. I. Apr-2010 In : British Journal of Dermatology. 162, 4, p. 939-940, 2 p., P34

    Research output: Contribution to journal › Book/Film/Article review

  35. Dermal fibroblast expression profiling implicates tumour microenvironment in the development of aggressive squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

    Ng, Y. Z., Pourreyron, C., Proby, C., Salas, J., Murrell, D. F., McGrath, J. A., Lane, E. B., Leigh, I. M. & South, A. P. Apr-2010 In : British Journal of Dermatology. 162, 4, p. 948-948, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  36. Immunohistochemical localization of cellular NFATc1 does not predict clinical responses to ciclosporin in subcutaneous panniculitis-like T-cell non-Hodgkin lymphoma

    Tauro, S., MacCallum, S., Groves, M. J., Rojnuckarin, P., Assanasen, T., Feldman, A. L., Robson, A., Marschalko, M., Kini, H., Alzolibani, A. A., Al Robaee, A., Al Shobaili, H. A., Alfawzan, S., Goodlad, J. R., Kernohan, N., Hummel, M., Sterry, W. & Assaf, C. Apr-2010 In : British Journal of Dermatology. 162, 4, p. 887-889, 3 p.

    Research output: Contribution to journal › Letter

  37. Peroxisome proliferator-activated receptor-delta genotype influences metabolic phenotype and may Influence lipid response to statin therapy in humans: A genetics of diabetes audit and research Tayside study

    Burch, L. R., Donnelly, L. A., Doney, A. S. F., Brady, J., Tommasi, A. M., Whitley, A. L., Goddard, C., Morris, A. D., Hansen, M. K. & Palmer, C. N. A. Apr-2010 In : Journal of Clinical Endocrinology & Metabolism. 95, 4, p. 1830-1837, 8 p.

    Research output: Contribution to journal › Article

  38. Keratin K6c mutations cause focal palmoplantar keratoderma

    Wilson, N. J., Messenger, A. G., Leachman, S. A., O'Toole, E. A., Lane, E. B., McLean, W. H. I. & Smith, F. J. D. Feb-2010 In : Journal of Investigative Dermatology. 130, 2, p. 425-429, 5 p.

    Research output: Contribution to journal › Article

  39. MdmX is a substrate for the deubiquitinating enzyme USP2a

    Allende-Vega, N., Sparks, A., Lane, D. P. & Saville, M. K. 21-Jan-2010 In : Oncogene. 29, 3, p. 432-441, 10 p.

    Research output: Contribution to journal › Article

  40. Loss-of-function CYP2C9 variants improve therapeutic response to sulfonylureas in type 2 diabetes: A Go-DARTS study

    Zhou, K., Donnelly, L., Burch, L., Tavendale, R., Doney, A. S. F., Leese, G., Hattersley, A. T., McCarthy, M. I., Morris, A. D., Lang, C. C., Palmer, C. N. A. & Pearson, E. R. Jan-2010 In : Clinical Pharmacology & Therapeutics. 87, 1, p. 52-56, 5 p.

    Research output: Contribution to journal › Article

  41. Late simultaneous metastasis of renal cell carcinoma to the submandibular and thyroid glands seven years after radical nephrectomy

    Miah, M., White, S., Oommen, G., Birney, E. & Majumdar, S. 2010 In : International Journal of Otolaryngology. 4 p., 698014

    Research output: Contribution to journal › Article

  42. Steatocystoma multiplex, oligodontia and partial persistent primary dentition associated with a novel keratin 17 mutation

    Gass, J. K., Wilson, N. J., Smith, F. J. D., Lane, E. B., McLean, W. H. I. M., Rytina, E., Salvary, I. & Burrows, N. P. Dec-2009 In : British Journal of Dermatology. 161, 6, p. 1396-1398, 3 p.

    Research output: Contribution to journal › Article

  43. A single nucleotide polymorphism on Exon-4 of the gene encoding PPAR delta is associated with reduced height inadults and children

    Burch, L. R., Zhou, K., Donnelly, L. A., Doney, A. S. F., Brady, J., Goddard, C., Morris, A. D., Hansen, M. K. & Palmer, C. N. A. Jul-2009 In : Journal of Clinical Endocrinology & Metabolism. 94, 7, p. 2587-2593, 7 p.

    Research output: Contribution to journal › Article

  44. Autoimmune pancytopenia following combination chemotherapy for chronic lymphocytic leukaemia

    MacCallum, S., Groves, M., Brass, D., Cunningham, J., Sales, M., Gelly, K. & Tauro, S. May-2009 In : Journal of Clinical Pathology. 62, 5, p. 468-470, 3 p.

    Research output: Contribution to journal › Article

  45. The annexin-V assay reflects susceptibility to in vitro membrane damage in chronic lymphocytic leukemia and may overestimate cell death

    Groves, M. J., MacCallum, S., Boylan, M. T., Coates, P. J. & Tauro, S. Mar-2009 In : American Journal of Hematology. 84, 3, p. 196-197, 2 p.

    Research output: Contribution to journal › Letter

  46. Suppression of the Deubiquitinating Enzyme USP5 Causes the Accumulation of Unanchored Polyubiquitin and the Activation of p53

    Dayal, S., Sparks, A., Jacob, J., Allende-Vega, N., Lane, D. & Saville, M. K. 20-Feb-2009 In : Journal of Biological Chemistry. 284, 8, p. 5030-5041, 12 p.

    Research output: Contribution to journal › Article

  47. Characterization, chemical optimization and anti-tumour activity of a tubulin poison identified by a p53-based phenotypic screen

    Staples, O. D., Hollick, J. J., Campbell, J., Higgins, M., McCarthy, A. R., Appleyard, V., Murray, K. E., Baker, L., Thompson, A., Ronseaux, S., Slawin, A. M. Z., Lane, D. P., Westwood, N. J. & Lain, S. 1-Nov-2008 In : Cell Cycle. 7, 21, p. 3417-3427, 11 p.

    Research output: Contribution to journal › Article

  48. Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita

    Leachman, S. A., Hickerson, R. P., Hull, P. R., Smith, F. J. D., Milstone, L. M., Lane, E. B., Bale, S. J., Roop, D. R., McLean, W. H. I. & Kaspar, R. L. Sep-2008 In : Journal of Dermatological Science. 51, 3, p. 151-157, 7 p.

    Research output: Contribution to journal › Scientific review

  49. Steatocystoma multiplex and persistent primary dentition due to a novel keratin 17 mutation

    Gass, J. K., Wilson, N. J., Smith, E. B. F., Lane, B., McLean, W. H. I., Salvary, I. & Burrows, N. P. Jul-2008 In : British Journal of Dermatology. 159, p. 119-119, 1 p., PA-13

    Research output: Contribution to journal › Book/Film/Article review

  50. Discovery, in vivo activity and mechanism of action of a small-molecule p53 activator

    Lain, S., Hollick, J. J., Campbell, J., Staples, O. D., Higgins, M., Aoubala, M., McCarthy, A., Appleyard, V., Murray, K. E., Baker, L., Thompson, A., Mathers, J., Holland, S. J., Stark, M. J. R., Pass, G., Woods, J., Lane, D. P. & Westwood, N. J. 6-May-2008 In : Cancer Cell. 13, 5, p. 454-463, 10 p.

    Research output: Contribution to journal › Article

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