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  1. Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence

    An, S., Caly, D. L., McCarthy, Y., Murdoch, S. L., Ward, J., Febrer, M., Dow, J. M. & Ryan, R. P. 16 Oct 2014 In : PLoS Pathogens. 10, 10, 12 p.e1004429

    Research output: Contribution to journalArticle

  2. POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in Head and Neck cancer

    Sharpe, D. J., Orr, K. S., Moran, M., White, S. J., McQuaid, S., Lappin, T. R., Thompson, A. & James, J. A. 16 Sep 2014 In : Oncotarget. 5, 18, p. 8803-8815 13 p.

    Research output: Contribution to journalArticle

  3. New and recurrent AAGAB mutations in punctate palmoplantar keratoderma

    Pohler, E., Huber, M., Boonen, S. E., Zamiri, M., Gregersen, P. A., Sommerlund, M., Ramsing, M., Hohl, D., McLean, W. H. I. & Smith, F. J. Aug 2014 In : British Journal of Dermatology. 171, 2, p. 433-436

    Research output: Contribution to journalLetter

  4. Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung

    McMillan, S. J., Sharma, R. S., Richards, H. E., Hegde, V. & Crocker, P. R. 18 Jul 2014 In : Journal of Biological Chemistry. 289, 29, p. 20370-20376 7 p.

    Research output: Contribution to journalArticle

  5. The PAS domain-containing histidine kinase RpfS is a second sensor for the diffusible signal factor of Xanthomonas campestris

    An, S-Q., Allan, J. H., McCarthy, Y., Febrer, M., Dow, J. M. & Ryan, R. P. May 2014 In : Molecular Microbiology. 92, 3, p. 586-597 12 p.

    Research output: Contribution to journalArticle

  6. Peptide aptamers define distinct EB1- and EB3-binding motifs and interfere with microtubule dynamics

    Lesniewska, K., Warbrick, E. & Ohkura, H. 1 Apr 2014 In : Molecular Biology of the Cell. 25, 7, p. 1025-1036 12 p.

    Research output: Contribution to journalArticle

  7. Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants

    Flohr, C., Perkin, M., Logan, K., Marrs, T., Radulovic, S., Campbell, L. E., Maccallum, S. F., McLean, W. H. I. & Lack, G. Feb 2014 In : Journal of Investigative Dermatology. 134, 2, p. 345-350 6 p.

    Research output: Contribution to journalArticle

  8. How detection of epigenetic alterations of blood-borne DNA could improve melanoma diagnosis

    Hatzimichael, E., Syed, N., Lo Nigro, C., Rao, B. & Crook, T. 2014 In : Expert Review of Molecular Diagnostics. 14, 6, p. 639-642 4 p.

    Research output: Contribution to journalArticle

  9. Heterozygous mutations in AAGAB cause type 1 punctate palmoplantar keratoderma with evidence for increased growth factor signaling

    Pohler, E., Zamiri, M., Harkins, C., Salas-Alanis, J. C., Perkins, W., Smith, F. J. D., McLean, W. H. I. & Brown, S. J. Dec 2013 In : Journal of Investigative Dermatology. 133, 12, p. 2805-2808 4 p.

    Research output: Contribution to journalLetter

  10. A cyclic GMP-dependent signalling pathway regulates bacterial phytopathogenesis

    An, S-Q., Chin, K-H., Febrer, M., McCarthy, Y., Yang, J-G., Liu, C-L., Swarbreck, D., Rogers, J., Dow, J. M., Chou, S-H. & Ryan, R. P. 11 Sep 2013 In : EMBO Journal. 32, 18, p. 2430-2438

    Research output: Contribution to journalArticle

  11. The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage

    Nicol, S. M., Bray, S. E., Derek Black, H., Lorimore, S. A., Wright, E. G., Lane, D. P., Meek, D. W., Coates, P. J. & Fuller-Pace, F. V. 18 Jul 2013 In : Oncogene. 32, 29, p. 3461-3469 9 p.

    Research output: Contribution to journalArticle

  12. Early-onset eczema and disease severity are the main risk factors for food sensitization at 3 months of age in exclusively breastfed infants

    Greenblatt, D., Perkin, M., Logan, K., Marrs, T., Radulovic, S., Campbell, L. E., MacCallum, S. F., McLean, W. H. I., Lack, G. & Flohr, C. Jul 2013 In : British Journal of Dermatology. 169, Suppl. 1, p. 113 1 p.PA01

    Research output: Contribution to journalMeeting abstract

  13. High-resolution transcriptional analysis of the regulatory influence of cell-to-cell signalling reveals novel genes that contribute to Xanthomonas phytopathogenesis

    An, S-Q., Febrer, M., McCarthy, Y., Tang, D-J., Clissold, L., Kaithakottil, G., Swarbreck, D., Tang, J-L., Rogers, J., Dow, J. M. & Ryan, R. P. Jun 2013 In : Molecular Microbiology. 88, 6, p. 1058-1069 12 p.

    Research output: Contribution to journalArticle

  14. Generation and characterisation of keratin 7 (K7) knockout mice

    Sandilands, A., Smith, F. J. D., Lunny, D. P., Campbell, L. E., Davidson, K. M., MacCallum, S. F., Corden, L. D., Christie, L., Fleming, S., Lane, E. B. & McLean, W. H. I. 31 May 2013 In : PLoS ONE. 8, 5, 11 p.e64404

    Research output: Contribution to journalArticle

  15. Reliability and validity of genotyping filaggrin null mutations

    Margolis, D. J., Apter, A. J., Mitra, N., Gupta, J., Hoffstad, O., Papadopoulos, M., Rebbeck, T. R., MacCallum, S., Campbell, L. E., Sandilands, A. & McLean, W. H. I. Apr 2013 In : Journal of Dermatological Science. 70, 1, p. 67-68 2 p.

    Research output: Contribution to journalLetter

  16. A Lack of premature termination codon read-through efficacy of PTC124 (Ataluren) in a diverse array of reporter assays

    McElroy, S. P., Nomura, T., Torrie, L. S., Warbrick, E., Gartner, U., Wood, G. & McLean, W. H. I. 2013 In : PLoS Biology. 11, 6, e1001593

    Research output: Contribution to journalArticle

  17. Allele-specific siRNA silencing for the common keratin 12 founder mutation in Meesmann epithelial corneal dystrophy

    Allen, E. H. A., Atkinson, S. D., Liao, H., Moore, J. E., Pedrioli, D. M. L., Smith, F. J. D., McLean, W. H. I. & Moore, C. B. T. 2013 In : Investigative Ophthalmology & Visual Science. 54, 1, p. 494-502 9 p.

    Research output: Contribution to journalArticle

  18. Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting

    Samuelov, L. , Sarig, O. , Harmon, R. M. , Rapaport, D. , Ishida-Yamamoto, A. , Isakov, O. , Koetsier, J. L. , Gat, A. , Goldberg, I. , Bergman, R. , Spiegel, R. , Eytan, O. , Geller, S. , Peleg, S. , Shomron, N. , Goh, C. S. M. , Wilson, N. J. , Smith, F. J. D. , Pohler, E. , Simpson, M. A. & 6 others McLean, W. H. I., Irvine, A. D., Horowitz, M., McGrath, J. A., Green, K. J. & Sprecher, E. 2013 In : Nature Genetics.

    Research output: Contribution to journalLetter

  19. Detecting and quantifying p53 isoforms at mRNA level in cell lines and tissues

    Khoury, M. P., Marcel, V., Fernandes, K., Diot, A., Lane, D. P. & Bourdon, J-C. 2013 p53 protocols. Deb, S. & Deb, S. P. (eds.). Totowa, N.J.: Humana Press, Vol. 962, p. 1-14 14 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  20. Detecting p53 isoforms at protein level

    Marcel, V., Khoury, M. P., Fernandes, K., Diot, A., Lane, D. P. & Bourdon, J-C. 2013 p53 protocols. Deb, S. & Deb, S. P. (eds.). Totowa, N.J.: Humana Press, Vol. 962, p. 15-29 15 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  21. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

    MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S. & Tauro, S. 2013 In : Scientific Reports. 3, 1275

    Research output: Contribution to journalArticle

  22. Heterozygous loss-of-function mutations in the AAGAB gene cause punctate palmoplantar keratoderma type 1 and impair receptor tyrosine kinase protein turnover

    Pohler, E., Harkins, C., Salas, J., Zamiri, M., Wilson, N. J., Smith, F. J., Brown, S. J. & McLean, I. 2013 In : Journal of Investigative Dermatology. 133, S1, p. S146 1 p.863

    Research output: Contribution to journalMeeting abstract

  23. Multiple self-healing squamous epithelioma (MSSE): rare variants in an adjacent region of chromosome 9q22.3 to Known TGFBR1 mutations suggest a digenic or multilocus etiology

    Chung Kang, H., Quigley, D. A., Kim, I-J., Wakabayashi, Y., Ferguson-Smith, M. A., D'Alessandro, M., Lane, B., Akhurst, R. J., Goudie, D. R. & Balmain, A. 2013 In : Journal of Investigative Dermatology. 133, 7, p. 1907-1910 4 p.

    Research output: Contribution to journalArticle

  24. Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma

    Brown, S. J. & 31 others Pohler, E., Mamai, O., Hirst, J., Zamiri, M., Horn, H., Nomura, T., Irvine, A. D., Moran, B., Wilson, N. J., Smith, F. J. D., Goh, C. S. M., Sandilands, A., Cole, C., Barton, G. J., Evans, A. T., Shimizu, H., Akiyama, M., Suehiro, M., Konohana, I., Shboul, M., Teissier, S., Boussofara, L., Denguezli, M., Saad, A., Gribaa, M., Dopping-Hepenstal, P. J., McGrath, J. A., Goudie, D. R., Reversade, B., Munro, C. S. & McLean, W. H. I. Nov 2012 In : Nature Genetics. 44, 11, p. 1272-1276 5 p.

    Research output: Contribution to journalArticle

  25. Haploinsufficiency for alpha- and gamma-adaptin binding protein (AAGAB) p34 causes clinically heterogeneous forms of punctate palmoplantar keratoderma

    Pohler, E., Mamai, O., Hirst, J., Zamiri, M., Horn, H., Irvine, A. D., Nomura, T., McGrath, J. A., Munro, C. S. & McLean, W. Sep 2012 In : Journal of Investigative Dermatology. 132, p. S89-S89 1 p.

    Research output: Contribution to journalMeeting abstract

  26. Influenza A viruses control expression of proviral human p53 isoforms p53β and Delta133p53α

    Terrier, O., Marcel, V., Cartet, G., Lane, D. P., Lina, B., Rosa-Calatrava, M. & Bourdon, J-C. Aug 2012 In : Journal of Virology. 86, 16, p. 8452-8460 9 p.

    Research output: Contribution to journalArticle

  27. Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin

    Sandilands, A., Brown, S. J., Goh, C. S., Pohler, E., Wilson, N. J., Campbell, L. E., Miyamoto, K., Kubo, A., Irvine, A. D., Thawer-Esmail, F., Munro, C. S., McLean, W. H. I., Kudoh, J., Amagai, M. & Matsui, T. May 2012 In : Journal of Investigative Dermatology. 132, 5, p. 1507-1510 4 p.

    Research output: Contribution to journalLetter

  28. The p53 isoforms are differentially modified by Mdm2

    Camus, S., Menendez, S., Fernandes, K., Kua, N., Liu, G., Xirodimas, D. P., Lane, D. P. & Bourdon, J-C. 15 Apr 2012 In : Cell Cycle. 11, 8, p. 1646-1655 10 p.

    Research output: Contribution to journalArticle

  29. Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect

    Brown, S. J., Kroboth, K., Sandilands, A., Campbell, L. E., Pohler, E., Kezic, S., Cordell, H. J., McLean, W. H. I. & Irvine, A. D. Jan 2012 In : Journal of Investigative Dermatology. 132, 1, p. 98-104 7 p.

    Research output: Contribution to journalArticle

  30. C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances

    Muller, P., Ruckova, E., Halada, P., Coates, P. J., Hrstka, R., Lane, D. P. & Vojtesek, B. 2012 In : Oncogene.

    Research output: Contribution to journalArticle

  31. Diverse p63 and p73 isoforms regulate Delta 133p53 expression through modulation of the internal TP53 promoter activity

    Marcel, V., Petit, I., Murray-Zmijewski, F., Goullet De Rugy, T., Fernandes, K., Meuray, V., Diot, A., Lane, D. P., Aberdam, D. & Bourdon, J-C. 2012 In : Cell Death & Differentiation. 19, 5, p. 816-826 11 p.

    Research output: Contribution to journalArticle

  32. Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

    Ng, Y-Z., Pourreyron, C., Salas-Alanis, J. C., Dayal, J. H. S., Cepeda-Valdes, R., Yan, W., Wright, S., Chen, M., Fine, J-D., Hogg, F. J., McGrath, J. A., Murrell, D. F., Leigh, I. M., Lane, E. B. & South, A. P. 2012 In : Cancer Research. 72, 14, p. 3522-3534 13 p.

    Research output: Contribution to journalArticle

  33. Heterogeneity of p53-pathway Protein Expression in Chemosensitive Chronic Lymphocytic Leukemia: A Pilot Study

    Groves, M. J., Maccallum, S. F., Boylan, M. T., Haydock, S., Cunningham, J., Gelly, K., Gowans, D., Kerr, R., Coates, P. J. & Tauro, S. 2012 In : Journal of Cancer. 3, p. 354-361 8 p.

    Research output: Contribution to journalArticle

  34. Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant

    Morris, A. D. & 21 others Palmer, C. N. A., Maglio, C., Pirazzi, C., Burza, M. A., Adiels, M., Burch, L., Donnelly, L. A., Colhoun, H., Doney, A. S., Dillon, J. F., Pearson, E. R., McCarthy, M., Hattersley, A. T., Frayling, T., Peltonen, M., Svensson, P-A., Jacobson, P., Borén, J., Sjöström, L., Carlsson, L. M. S. & Romeo, S. 2012 In : PLoS ONE. 7, 6, e39362

    Research output: Contribution to journalArticle

  35. Scanning Ion Conductance Microscopy of Live Keratinocytes

    Hegde, V., Mason, A., Saliev, T., Smith, F., McLean, W. H. I. & Campbell, P. A. 2012 Electron Microscopy and Analysis Group Conference 2011 (EMAG 2011). Bristol: Institute of Physics, p. - 4 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  36. The mechanical behavior of mutant K14-R125P keratin bundles and networks in NEB-1 keratinocytes

    Beriault, D. R., Haddad, O., McCuaig, J. V., Robinson, Z. J., Russell, D., Lane, E. B. & Fudge, D. S. 2012 In : PLoS ONE. 7, 2, p. - 10 p.e31320

    Research output: Contribution to journalArticle

  37. Advances in bacterial transcriptome and transposon insertion-site profiling using second-generation sequencing

    Febrer, M., McLay, K., Caccamo, M., Twomey, K. B. & Ryan, R. . P. 1 Nov 2011 In : Trends in Biotechnology. 29, 11, p. 586-594 9 p.

    Research output: Contribution to journalScientific review

  38. Extracellular matrix composition in dermal microenvironment is implicated in development of life threatening cutaneous squamous cell carcinoma

    Ng, Y. Z., Pourreyron, C., Salas-Alanis, J. C., Murrell, D. F., McGrath, J. A., Lane, E. B. & South, A. P. Sep 2011 In : Journal of Investigative Dermatology. 131, p. S32-S32 1 p.190

    Research output: Contribution to journalBook/Film/Article review

  39. Primary cutaneous CD8-positive T-cell Lymphoma: a case report of a rare and aggressive disease with oral presentation

    Geddes, A., Savin, J., White, S. & Gibson, J. Sep 2011 In : Dental Update. 38, 7, p. 472-4, 476 4 p.

    Research output: Contribution to journalArticle

  40. Keratin 14-Null Cells as a Model to Test the Efficacy of Gene Therapy Approaches in Epithelial Cells

    D'Alessandro, M., Coats, S. E., Jonkmann, M. F., Leigh, I. M. & Lane, B. Jul 2011 In : Journal of Investigative Dermatology. 131, 7, p. 1412-1419 8 p.

    Research output: Contribution to journalArticle

  41. Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations

    Chen, H., Common, J. E. A., Haines, R. L., Balakrishnan, A., Brown, S. J., Goh, C. S. M., Cordell, H. J., Sandilands, A., Campbell, L. E., Kroboth, K., Irvine, A. D., Goh, D. L. M., Tang, M. B. Y., van Bever, H. P., Giam, Y. C., McLean, W. H. I. & Lane, E. B. Jul 2011 In : British Journal of Dermatology. 165, 1, p. 106-114 9 p.

    Research output: Contribution to journalArticle

  42. Filaggrin null mutations are not a protective factor for acne vulgaris

    Common, J. E. A., Brown, S. J., Haines, R. L., Goh, C. S. M., Chen, H., Balakrishnan, A., Munro, C. S., Tan, A. W. H., Tan, H. H., Tang, M. B. Y. & Lane, E. B. Jun 2011 In : Journal of Investigative Dermatology. 131, 6, p. 1378-1380 3 p.

    Research output: Contribution to journalLetter

  43. Statins downregulate K6a promoter activity: a possible therapeutic avenue for pachyonychia congenita

    Zhao, Y., Gartner, U., Smith, F. J. D. & McLean, W. H. I. May 2011 In : Journal of Investigative Dermatology. 131, 5, p. 1045-1052 8 p.

    Research output: Contribution to journalArticle

  44. Copy number variation within the filaggrin gene contributes to risk of atopic dermatitis

    Brown, S. J., Kroboth, K., Sandilands, A., Campbell, L. E., Pohler, E., Irvine, A. D., Cordell, H. J. & McLean, W. Apr 2011 In : Journal of Investigative Dermatology. 131, Supplement 1, p. S63-S63 1 p.375

    Research output: Contribution to journalBook/Film/Article review

  45. Developing small molecule drugs to rescue nonsense mutations in disease-causing genes

    Nomura, T., Gartner, U., McElroy, S., Torrie, L., Pourreyron, C., South, A. P., Wood, G., Woodland, A., Frearson, J., Wyatt, P. & McLean, I. Apr 2011 In : Journal of Investigative Dermatology. 131, p. S67-S67 1 p.397

    Research output: Contribution to journalBook/Film/Article review

  46. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

    Morris, A. D. , Sutherland, C. & 49 others Zhou, K., Bellenguez, C., Spencer, C. C. A., Bennett, A. J., Coleman, R. L., Tavendale, R., Hawley, S. A., Donnelly, L. A., Schofield, C., Groves, C. J., Burch, L., Carr, F., Strange, A., Freeman, C., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Craddock, N., Deloukas, P., Dronov, S., Duncanson, A., Edkins, S., Gray, E., Hunt, S., Jankowski, J., Langford, C., Markus, H. S., Mathew, C. G., Plomin, R., Rautanen, A., Sawcer, S. J., Samani, N. J., Trembath, R., Viswanathan, A. C., Wood, N. W., Harries, L. W., Hattersley, A. T., Doney, A. S. F., Colhoun, H., Hardie, D. G., Peltonen, L., McCarthy, M. I., Holman, R. R., Palmer, C. N. A., Donnelly, P., Pearson, E. R. & Wellcome Trust Case Control Consor, GoDARTS UKPDS Diabet Pharmacogenet, MAGIC Investigators Feb 2011 In : Nature Genetics. 43, 2, p. 117-120 4 p.

    Research output: Contribution to journalLetter

  47. p53 directly transactivates Delta 133p53 alpha, regulating cell fate outcome in response to DNA damage

    Aoubala, M., Murray-Zmijewski, F., Khoury, M. P., Fernandes, K., Perrier, S., Bernard, H., Prats, A-C., Lane, D. P. & Bourdon, J-C. Feb 2011 In : Cell Death & Differentiation. 18, 2, p. 248-258 11 p.

    Research output: Contribution to journalArticle

  48. Cyp2c8 variant reduce the therapeutic response to thiazolidinediones - a godarts study

    Zhou, K., Burch, L., Vella, S., Palmer, C. N. A. & Pearson, E. R. Sep 2010 In : Diabetologia. 53, p. S133-S133 1 p.

    Research output: Contribution to journalBook/Film/Article review

  49. Tumour microenvironment is implicated by dermal fibroblast expression profiling in the development of aggressive squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa

    Ng, Y. Z., Pourreyron, C., Salas-Alanis, J. C., Murrell, D. F., McGrath, J. A., Lane, E. B., Leigh, I. & South, A. Sep 2010 In : Journal of Investigative Dermatology. 130, p. S83-S83 1 p.

    Research output: Contribution to journalBook/Film/Article review

  50. Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults

    Mukhopadhyay, S., Sypek, J., Tavendale, R., Gartner, U., Winter, J., Li, W., Page, K., Fleming, M., Brady, J., O'Toole, M., Macgregor, D. F., Goldman, S., Tam, S., Abraham, W., Williams, C., Miller, D. K. & Palmer, C. N. A. Jul 2010 In : Journal of Allergy and Clinical Immunology. 126, 1, p. 70-76 7 p.

    Research output: Contribution to journalArticle

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