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MRC Protein Phosphorylation Unit

  1. The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

    Hoxhaj, G., Caddye, E., Najafov, A., Houde, V. P., Johnson, C., Dissanayake, K., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 22 Apr 2016 In : eLife. 5, e12278

    Research output: Contribution to journalArticle

  2. Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases

    Steger, M., Tonelli, F., Ito, G., Davies, P., Trost, M., Vetter, M., Wachter, S., Lorentzen, E., Duddy, G., Wilson, S., Baptista, M. A. S., Fiske, B. K., Fell, M. J., Morrow, J. A., Reith, A. D., Alessi, D. R. & Mann, M. 29 Jan 2016 In : eLife. 5, JANUARY2016, e12813

    Research output: Contribution to journalArticle

  3. High-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow-derived macrophages

    Guo, M., Härtlova, A., Dill, B. D., Prescott, A. R., Gierliński, M. & Trost, M. Sep 2015 In : Proteomics. 15, 18, p. 3169-3174 6 p.

    Research output: Contribution to journalArticle

  4. Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

    Kazlauskaite, A., Martínez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H. & Muqit, M. M. K. 1 Aug 2015 In : EMBO Reports. 16, 8, p. 939-954 16 p.

    Research output: Contribution to journalArticle

  5. The promise and peril of chemical probes

    Arrowsmith, C. H. , Audia, J. E. , Austin, C. , Baell, J. , Bennett, J. , Blagg, J. , Bountra, C. , Brennan, P. E. , Brown, P. J. , Bunnage, M. E. , Buser-Doepner, C. , Campbell, R. M. , Carter, A. J. , Cohen, P. , Copeland, R. A. , Cravatt, B. , Dahlin, J. L. , Dhanak, D. , Edwards, A. M. & 35 others Frederiksen, M., Frye, S. V., Gray, N., Grimshaw, C. E., Hepworth, D., Howe, T., Huber, K. V. M., Jin, J., Knapp, S., Kotz, J. D., Kruger, R. G., Lowe, D., Mader, M. M., Marsden, B., Mueller-Fahrnow, A., Müller, S., O'Hagan, R. C., Overington, J. P., Owen, D. R., Rosenberg, S. H., Roth, B., Ross, R., Schapira, M., Schreiber, S. L., Shoichet, B., Sundström, M., Superti-Furga, G., Taunton, J., Toledo-Sherman, L., Walpole, C., Walters, M. A., Willson, T. M., Workman, P., Young, R. N. & Zuercher, W. J. Aug 2015 In : Nature Chemical Biology. 11, 8, p. 536-541 6 p.

    Research output: Contribution to journalComment/debate

  6. A versatile strategy for the semisynthetic production of Ser65 phosphorylated ubiquitin and its biochemical and structural characterisation

    Han, C., Pao, K-C., Kazlauskaite, A., Muqit, M. M. K. & Virdee, S. 27 Jul 2015 In : ChemBioChem. 16, 11, p. 1574-1579 6 p.

    Research output: Contribution to journalArticle

  7. Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance

    McNeil, E. M., Astell, K. R., Ritchie, A. M., Shave, S., Houston, D. R., Bakrania, P., Jones, H. M., Khurana, P., Wallace, C., Chapman, T., Wear, M. A., Walkinshaw, M. D., Saxty, B. & Melton, D. W. 1 Jul 2015 In : DNA Repair. 31, p. 19-28 10 p.

    Research output: Contribution to journalArticle

  8. Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog

    Rogerson, D. T., Sachdeva, A., Wang, K., Haq, T., Kazlauskaite, A., Hancock, S. M., Huguenin-Dezot, N., Muqit, M. M. K., Fry, A. M., Bayliss, R. & Chin, J. W. Jul 2015 In : Nature Chemical Biology. 11, 7, p. 496-503 8 p.

    Research output: Contribution to journalArticle

  9. Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members

    Malik, N., Vollmer, S., Nanda, S. K., Lopez-Pelaez, M., Prescott, A., Gray, N. & Cohen, P. 15 Jun 2015 In : Biochemical Journal. 468, 3, p. 363-372 10 p.

    Research output: Contribution to journalArticle

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