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MRC Protein Phosphorylation Unit

  1. Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

    Kazlauskaite, A., Martínez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H. & Muqit, M. M. K. 1 Aug 2015 In : EMBO Reports. 16, 8, p. 939-954 16 p.

    Research output: Contribution to journalArticle

  2. The promise and peril of chemical probes

    Arrowsmith, C. H. , Audia, J. E. , Austin, C. , Baell, J. , Bennett, J. , Blagg, J. , Bountra, C. , Brennan, P. E. , Brown, P. J. , Bunnage, M. E. , Buser-Doepner, C. , Campbell, R. M. , Carter, A. J. , Cohen, P. , Copeland, R. A. , Cravatt, B. , Dahlin, J. L. , Dhanak, D. , Edwards, A. M. , Frye, S. V. & 33 others Gray, N., Grimshaw, C. E., Hepworth, D., Howe, T., Huber, K. V. M., Jin, J., Knapp, S., Kotz, J. D., Kruger, R. G., Lowe, D., Mader, M. M., Marsden, B., Mueller-Fahrnow, A., Müller, S., O'Hagan, R. C., Overington, J. P., Owen, D. R., Rosenberg, S. H., Roth, B., Ross, R., Schapira, M., Schreiber, S. L., Shoichet, B., Sundström, M., Superti-Furga, G., Taunton, J., Toledo-Sherman, L., Walpole, C., Walters, M. A., Willson, T. M., Workman, P., Young, R. N. & Zuercher, W. J. Aug 2015 In : Nature Chemical Biology. 11, 8, p. 536-541 6 p.

    Research output: Contribution to journalComment/debate

  3. A versatile strategy for the semisynthetic production of Ser65 phosphorylated ubiquitin and its biochemical and structural characterisation

    Han, C., Pao, K-C., Kazlauskaite, A., Muqit, M. M. K. & Virdee, S. 27 Jul 2015 In : ChemBioChem. 16, 11, p. 1574-1579 6 p.

    Research output: Contribution to journalArticle

  4. Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance

    McNeil, E. M., Astell, K. R., Ritchie, A. M., Shave, S., Houston, D. R., Bakrania, P., Jones, H. M., Khurana, P., Wallace, C., Chapman, T., Wear, M. A., Walkinshaw, M. D., Saxty, B. & Melton, D. W. 1 Jul 2015 In : DNA Repair. 31, p. 19-28 10 p.

    Research output: Contribution to journalArticle

  5. Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog

    Rogerson, D. T., Sachdeva, A., Wang, K., Haq, T., Kazlauskaite, A., Hancock, S. M., Huguenin-Dezot, N., Muqit, M. M. K., Fry, A. M., Bayliss, R. & Chin, J. W. Jul 2015 In : Nature Chemical Biology. 11, 7, p. 496-503 8 p.

    Research output: Contribution to journalArticle

  6. Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members

    Malik, N., Vollmer, S., Nanda, S. K., Lopez-Pelaez, M., Prescott, A., Gray, N. & Cohen, P. 15 Jun 2015 In : Biochemical Journal. 468, 3, p. 363-372 10 p.

    Research output: Contribution to journalArticle

  7. Structural characterization of LRRK2 inhibitors

    Gilsbach, B. K., Messias, A. C., Ito, G., Sattler, M., Alessi, D. R., Wittinghofer, A. & Kortholt, A. 14 May 2015 In : Journal of Medicinal Chemistry. 58, 9, p. 3751-3756 6 p.

    Research output: Contribution to journalArticle

  8. Quantitative proteome analysis of temporally-resolved phagosomes following uptake via key phagocytic receptors

    Dill, B., Gierliński, M., Härtlova, A., González Arandilla, A., Guo, M., Clarke, R. G. & Trost, M. 1 May 2015 In : Molecular & Cellular Proteomics. 14, 5, p. 1334 1349 p., 16

    Research output: Contribution to journalArticle

  9. Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9

    Rojas-Fernandez, A., Herhaus, L., Macartney, T., Lachaud, C., Hay, R. T. & Sapkota, G. P. 29 Apr 2015 In : Scientific Reports. 5, 6 p., 9811

    Research output: Contribution to journalArticle

  10. Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations

    Kristariyanto, Y. A., Choi, S-Y., Rehman, S. A. A., Ritorto, M. S., Campbell, D. G., Morrice, N. A., Toth, R. & Kulathu, Y. 15 Apr 2015 In : Biochemical Journal. 467, 2, p. 345-352 8 p.

    Research output: Contribution to journalArticle

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