MRC Protein Phosphorylation Unit

Kinase drug discovery: What's next in the field?

Cohen, P. & Alessi, D. R. 2013 In : ACS Chemical Biology. 8, 1, p. 96-104, 9 p.

Research output: Contribution to journal › Article

MSK1 and 2 inhibit LPS induced prostaglandin production via an IL-10 feedback loop

Mackenzie, K. F., Van Den Bosch, M. W. M., Naqvi, S., Elcombe, S. E., McGuire, V. A., Reith, A. D., Blackshear, P. J., Dean, J. L. & Arthur, J. S. C. 2013 In : Molecular and Cellular Biology.

Research output: Contribution to journal › Article

Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer

Alessi, D. R. & 21 others Eser, S., Reiff, N., Messer, M., Seidler, B., Gottschalk, K., Dobler, M., Hieber, M., Arbeiter, A., Klein, S., Kong, B., Michalski, C. W., Schlitter, A. M., Esposito, I., Kind, A. J., Rad, L., Schnieke, A. E., Baccarini, M., Rad, R., Schmid, R. M., Schneider, G. & Saur, D. 2013 In : Cancer Cell. 23, 3, p. 406-420, 15 p.

Research output: Contribution to journal › Article

The ULK1 complex Sensing nutrient signals for autophagy activation

Wong, P-M., Puente, C., Ganley, I. G. & Jiang, X. 2013 In : Autophagy. 9, 2, p. 124-137, 14 p.

Research output: Contribution to journal › Article

Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P-3-dependent mechanisms leading to resistance to PDK1 inhibitors

Najafov, A., Shpiro, N. & Alessi, D. R. Dec-2012 In : Biochemical Journal. 448, 2, p. 285-295, 11 p.

Research output: Contribution to journal › Article

Selective kinase inhibitors as tools for neuroscience research

Martin, K. J. & Arthur, J. S. C. Dec-2012 In : Neuropharmacology. 63, 7, p. 1227-1237, 11 p.

Research output: Contribution to journal › Article

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

McIver, E. G., Bryans, J., Birchall, K., Chugh, J., Drake, T., Lewis, S. J., Osborne, J., Smiljanic-Hurley, E., Tsang, W., Kamal, A., Levy, A., Newman, M., Taylor, D., Arthur, J. S. C., Clark, K. & Cohen, P. Dec-2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 23, p. 7169-7173, 5 p.

Research output: Contribution to journal › Article

Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase

Shehata, S. N., Hunter, R. W., Ohta, E., Peggie, M. W., Lou, H. J., Sicheri, F., Zegiraj, E., Turk, B. E. & Sakamoto, K. Nov-2012 In : Cellular Signalling. 24, 11, p. 2085-2094, 10 p.

Research output: Contribution to journal › Article

Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway

Bruce, D. L., Macartney, T., Yong, W., Shou, W. & Sapkota, G. P. Nov-2012 In : Cellular Signalling. 24, 11, p. 1999-2006, 8 p.

Research output: Contribution to journal › Article

ZNRF2 is released from membranes by growth factors and with ZNRF1 regulates the Na+/K+ATPase

Hoxhaj, G., Najafov, A., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 1-Oct-2012 In : Journal of Cell Science. 125, 19, p. 4662-4675

Research output: Contribution to journal › Article