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MRC Protein Phosphorylation Unit

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  1. Mechanism of Action of Compound-13: an α1-Selective Small Molecule Activator of AMPK

    Hunter, R. W., Foretz, M., Bultot, L., Fullerton, M. D., Deak, M., Ross, F. A., Hawley, S. A., Shpiro, N., Viollet, B., Barron, D., Kemp, B. E., Steinberg, G. R., Hardie, D. G. & Sakamoto, K. 2014 In : Chemistry & Biology. 21, 7, p. 866-879 14 p.

    Research output: Contribution to journalArticle

  2. Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Serine65

    Kazlauskaite, A., Kondapalli, C., Gourlay, R., Campbell, D. G., Ritorto, M. S., Hofmann, K., Alessi, D. R., Knebel, A., Trost, M. & Muqit, M. M. K. 2014 In : Biochemical Journal. 460, 1, p. 127-139 13 p.

    Research output: Contribution to journalArticle

  3. Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling

    Vogt, J., Dingwell, K. S., Herhaus, L., Gourlay, R., Macartney, T., Campbell, D., Smith, J. C. & Sapkota, G. P. 2014 In : Open Biology. 4, FEB

    Research output: Contribution to journalArticle

  4. Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation

    Schumacher, F-R., Sorrell, F. J., Alessi, D. R., Bullock, A. N. & Kurz, T. 2014 In : Biochemical Journal. 460, 2, p. 237-246 10 p.

    Research output: Contribution to journalArticle

  5. Structural basis for the recruitment of glycogen synthase by glycogenin

    Zeqiraj, E., Tang, X., Hunter, R. W., García-Rocha, M., Judd, A., Deak, M., Von Wilamowitz-Moellendorff, A., Kurinov, I., Guinovart, J. J., Tyers, M., Sakamoto, K. & Sicheri, F. 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. E2831-E2840 10 p.

    Research output: Contribution to journalArticle

  6. The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways

    Herhaus, L. & Sapkota, G. P. 2014 In : Cellular Signalling. 26, 10, p. 2186-2192 7 p.

    Research output: Contribution to journalArticle

  7. Transcriptional regulation of IL-10 and its cell-specific role in vivo

    MacKenzie, K. F., Pattison, M. & Arthur, J. S. C. 2014 In : Critical Reviews in Immunology. 34, 4, p. 315-345 31 p.

    Research output: Contribution to journalArticle

  8. VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase

    Baron, Y., Pedrioli, P. G., Tyagi, K., Johnson, C., Wood, N. T., Fountaine, D., Wightman, M. & Alexandru, G. 2014 In : BMC Biology. 12, 39

    Research output: Contribution to journalArticle

  9. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis

    von Wilamowitz-Moellendorff, A., Hunter, R. W., García-Rocha, M., Kang, L., López-Soldado, I., Lantier, L., Patel, K., Peggie, M. W., Martínez-Pons, C., Voss, M., Calbó, J., Cohen, P. T. W., Wasserman, D. H., Guinovart, J. J. & Sakamoto, K. Dec 2013 In : Diabetes. 62, 12, p. 4070-4082 13 p.

    Research output: Contribution to journalArticle

  10. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

    Deng, X., Elkins, J. M., Zhang, J., Yang, Q., Erazo, T., Gomez, N., Choi, H. G., Wang, J., Dzamko, N., Lee, J-D., Sim, T., Kim, N., Alessi, D. R., Lizcano, J. M., Knapp, S. & Gray, N. S. Dec 2013 In : European Journal of Medicinal Chemistry. 70, p. 758-767 10 p.

    Research output: Contribution to journalArticle

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