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MRC Protein Phosphorylation Unit

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  1. The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys(63)-linked polyubiquitination of IRAK1

    Ordureau, A., Smith, H., Windheim, M., Peggie, M., Carrick, E., Morrice, N. & Cohen, P. 2008 In : Biochemical Journal. 409, 1, p. 43-52 10 p.

    Research output: Contribution to journalArticle

  2. The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2

    Paytubi, S., Morrice, N. A., Boudeau, J. & Proud, C. G. 2008 In : Biochemical Journal. 409, 1, p. 223-231 9 p.

    Research output: Contribution to journalArticle

  3. The selectivity of protein kinase inhibitors: a further update

    Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., Mclauchlan, H., Klevernic, I., Arthur, J. S. C., Alessi, D. R. & Cohen, P. 15 Dec 2007 In : Biochemical Journal. 408, p. 297-315 19 p.

    Research output: Contribution to journalArticle

  4. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator

    Lain, S., Hollick, J., Campbell, J., Staples, O. D., Higgins, M., Aoubala, M., McCarthy, A., Appleyard, V., Murray, K., Thompson, A., Mathers, J., Holland, S., Stark, M. J. R., Lane, D. & Westwood, N. J. Dec 2007 In : Molecular Cancer Therapeutics. 6, 12, p. 3476S-3477S 2 p.

    Research output: Contribution to journalBook/Film/Article review

  5. The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

    Zaru, R., Ronkina, N., Gaestel, M., Arthur, S. & Watts, C. Nov 2007 In : Nature Immunology. 8, 11, p. 1227-1235 9 p.

    Research output: Contribution to journalArticle

  6. BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

    Sapkota, G. P., Cummings, L., Newell, F. S., Armstrong, C., Bain, J., Frodin, M., Grauert, M., Hoffmann, M., Schnapp, G., Steegmaier, M., Cohen, P. & Alessi, D. R. 16 Oct 2007 In : Biochemical Journal. 401, 1, p. 29-38 10 p.

    Research output: Contribution to journalArticle

  7. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR

    Geraghty, K. M., Chen, S., Harthill, J. E., Ibrahim, A. F., Toth, R., Morrice, N. A., Vandermoere, F., Moorhead, G. B., Hardie, D. G. & MacKintosh, C. 15 Oct 2007 In : Biochemical Journal. 407, p. 231-241 11 p.

    Research output: Contribution to journalArticle

  8. Structural insights into the recognition of substrates and activators by the OSR1 kinase

    Villa, F., Goebel, J., Rafiqi, F. H., Deak, M., Thastrup, J., Alessi, D. R. & van Aalten, D. M. F. 1 Sep 2007 In : EMBO Reports. 8, 9, p. 839-845 7 p.

    Research output: Contribution to journalArticle

  9. Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

    Logie, L., Ruiz-Alcaraz, A. J., Keane, M., Woods, Y. L., Bain, J., Marquez, R., Alessi, D. R. & Sutherland, C. Sep 2007 In : Diabetes. 56, 9, p. 2218-2227 10 p.

    Research output: Contribution to journalArticle

  10. PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

    Fonseca, B. D., Smith, E. M., Lee, V. H. -Y., MacKintosh, C. & Proud, C. G. 24 Aug 2007 In : Journal of Biological Chemistry. 282, 34, p. 24514-24524 11 p.

    Research output: Contribution to journalArticle

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