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MRC Protein Phosphorylation Unit

  1. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

    Bayascas, J. R., Wullschleger, S., Sakamoto, K., Garcia-Martinez, J. M., Clacher, C., Komander, D., van Aalten, D. M. F., Boini, K. M., Lan, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., van Diepen, J. A., Voshol, P. J., Lucocq, J. M. & Alessi, D. R. May 2008 In : Molecular and Cellular Biology. 28, 10, p. 3258-3272 15 p.

    Research output: Contribution to journalArticle

  2. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-inked polyubiquitin chains

    Al-Hakim, A. K., Zagorska, A., Chapman, L., Deak, M., Peggie, M. & Alessi, D. R. 15 Apr 2008 In : Biochemical Journal. 411, p. 249-260 12 p.

    Research output: Contribution to journalArticle

  3. Combined enzymatic and data mining approaches for comprehensive phosphoproteome analyses: application to cell signaling events of interferon-gamma-stimulated macrophages

    Marcantonio, M., Trost, M., Courcelles, M., Desjardins, M. & Thibault, P. 1 Apr 2008 In : Molecular & Cellular Proteomics. 7, 4, p. 645-660 16 p.

    Research output: Contribution to journalArticle

  4. PDK1, but not PKB, is required for the activation of the Mtor/P70s6k pathway by leucine in the heart

    Canedo, C. S., Beauloye, C., Demeulder, B., Ginion, A., Zarrinpashneh, E., Alessi, D. R., Hue, L., Vanoverschelde, J. -L. & Bertrand, L. Apr 2008 In : Cardiovascular Drugs and Therapy. 22, 2, p. 150-150 1 p.

    Research output: Contribution to journalArticle

  5. Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

    Morton, S., Hesson, L., Peggie, M. & Cohen, P. 19 Mar 2008 In : FEBS Letters. 582, 6, p. 997-1002 6 p.

    Research output: Contribution to journalArticle

  6. Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

    Richardson, C., Rafiqi, F. H., Karlsson, H. K. R., Moleleki, N., Vandewalle, A., Campbell, D. G., Morrice, N. A. & Alessi, D. R. 1 Mar 2008 In : Journal of Cell Science. 121, 5, p. 675-684 10 p.

    Research output: Contribution to journalArticle

  7. Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IκBα kinase

    Windheim, M., Stafford, M., Peggie, M. & Cohen, P. Mar 2008 In : Molecular and Cellular Biology. 28, 5, p. 1783-1791 9 p.

    Research output: Contribution to journalArticle

  8. Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE)

    Deutsch, E. W. , Ball, C. A. , Berman, J. J. , Bova, G. S. , Brazma, A. , Bumgarner, R. E. , Campbell, D. , Causton, H. C. , Christiansen, J. H. , Daian, F. , Dauga, D. , Davidson, D. R. , Gimenez, G. , Goo, Y. A. , Grimmond, S. , Henrich, T. , Herrmann, B. G. , Johnson, M. H. , Korb, M. , Mills, J. C. & 20 others Oudes, A. J., Parkinson, H. E., Pascal, L. E., Pollet, N., Quackenbush, J., Ramialison, M., Ringwald, M., Salgado, D., Sansone, S-A., Sherlock, G., Stoeckert, C. J., Swedlow, J., Taylor, R. C., Walashek, L., Warford, A., Wilkinson, D. G., Zhou, Y., Zon, L. I., Liu, A. Y. & True, L. D. Mar 2008 In : Nature Biotechnology. 26, 3, p. 305-312 8 p.

    Research output: Contribution to journalArticle

  9. Systems biology analysis of phagosomes from Interferon-gamma activated mouse macrophages

    Trost, M., Lemieux, S., Thibault, P. & Desjardins, M. Mar 2008 In : European Journal of Cell Biology. 87, Supplement 1, p. 53-53 1 p.MS4-2

    Research output: Contribution to journalMeeting abstract

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